Chemistry & Biochemistry

Abigail Kenning, 2021

The Role of Calcium in Global Chromatin Compaction and Protection in Response to UV

This project focuses on determining if the use of chemical inhibitors on factors in the calcium signaling pathway of human epidermal melanocytes affect chromatin compaction in response to UV-B irradiation. The final product consists of a 10-page research paper outlining findings.

Course: BIOL 4813

Supervising Professor: Michael Bergel

Lindsay little, 2020

Synthesis of a Simple Quaternized Alkyl Diamine and Its Comparison with a Gemini Surfactant

This project will analyze the conformational properties of DNA quadruplexes and their biological roles. The experiments performed will synthesize certain compounds that will be used to probe the surface of a DNA quadruplex. The results will be articulated in a research paper and presented at TWU Creative Arts and Research symposium and national conferences.

Course: CHEM 4983

Supervising Professor: Richard Sheardy

Catherine perez, 2020

Studying the Interaction of DNA with Platinum-based Anticancer Drugs with UV-Vis Spectroscopy

Focusing on the interaction of the DNA base, this project looks at guanine in various solutions in order to better understand how different experimental conditions will affect the vibrational frequencies of guanine. The application of the findings of this project help to further understand the binding/interaction of the guanine base with anticancer drugs like cisplatin and carboplatin in various environments. This is articulated through a research paper and poster presentation at the TWU Student Creative Arts and Research Symposium.

Course: CHEM 4983

Supervising Professor: Nasrin Mirsaleh-Kohan

Claudette Fraire, 2019

Exploring the Kinetics of Global Core Histone Acetylation Upon UVC Irradiation in Yeast

I will explore the kinetics of global core histone acetylation upon UVC irradiation in yeast.

Course: BIOL 4983

Supervising Professor: Heather Conrad-Webb

Joel Mathews, 2018

Expression of Soluble Human-Glutamylcysteine Synthetase

I will focus on increasing expression of soluble _-glutamylcysteine synthetase (GCS) and GCSC to furtherunderstand the structure and regulation of GCS.

Course: CHEM 4983

Supervising Professor: Mary Anderson

Tra Nguyen, 2018

Critique of Shifting Specificity Model for Enzyme Catalysis

I will research other scientists' opinions of the Shifting Specificity model (SSM) for enzyme catalysis and determine its validity.

Course: CHEM 3423

Supervising Professor: Mark Britt

Paige Hall, 2017

Investigating Interactions of DNA and Platinum-Based Drugs (Carboplatin and Heptaplatin) Utilizing the Spectroscopy Techniques of Surface-Enhanced Raman Spectroscopy (SERS) and Circular Dichroism (CD)

I will study how carboplatin and heptaplatin modify DNA (COTAR2) under various experimental conditions to better understand the drug-DNA interactions that occur with the therapeutic agents used to treat cancer.

Course: CHEM 4983

Supervising Professor: Nasrin Mirsaleh-Ko

Giselle Vigil, 2017

Implementation of New Computer-Based Experiments in Physics Courses

Using the PASCO Capstone Software, I will improve physics lab experiments and write full lab reports to serve as helpful examples for future Physics I and II students and teaching assistants.

Course: CHEM 4913

Supervising Professor: Nasrin Mirsaleh-Kohan

cARELY ibARRA, 2015

Green Chemistry: Importance and Methods to Implement It on Campus

I will raise awareness about the importance of green chemistry (to reduce/eliminate the use and generationof hazardous substances in chemical products and processes) and design alternate green experiments for a general chemistry lab.

Course: CHEM 4913

Supervising Professor: Richard Sheardy

Krystal Scott, 2007

Characterization of the Human Telomeric Repeat (TT AGGG)4, (CCCT AA)4, and Their Duplex in Potassium Solution

I will characterize the complement to the human telomeric sequence, (CCCTAA)4, as well as the duplex formed from a stoichiometric mixture of the two.

Course: CHEM 4983

Supervising Professor: Richard Sheardy

Alexis Fergis, 2015

Greening TWU's Teaching Labs: The Environmentally Friendly Approach to Organic Chemistry

I will focus on increasing product yields, minimizing waste products, and decreasing heating times of reactions using high-powered synthesis microwave.

Course: CHEM 4983

Supervising Professor: Richard Sheardy

Perla Gonzalez, 2013

Function of Arginine 267 in Glutathione Synthetase

I will study the cellular role of glutathione and the regulation and biosynthesis of glutathione within living cells.

Course: CHEM 4983

Supervising Professor: Mary Anderson

Jillion Crawford, 2012

Pioneering Medicine: The Story of Elizabeth Blackwell, the First Female Physician

I will research the life of Elizabeth Blackwell and the social conditions affecting medicine during her time and conclude with a brief overview of the progression of women in medicine and contemporary society.

Course: HIST 4913

Supervising Professor: Paul Travis

Victoria Loveland, 2010

Preservation of RNA in Different Tissues with 3.5 M Ammonium Sulfate

I will determine if 3.5 M ammonium sulfate will act as a preservative and maintain good RNA quality in tissues other than the liver.

Course: BIOL 4983

Supervising Professor: Nathaniel Mills

Rae McFarlin, 2010

Synthesis of Z and E Methyl O-Methyl Cinnamothiohydroximate

I will synthesize Zand E methyl O-methyl cinnamothiohydroximate and study the mechanism of the acidcatalyzed Z/E isomerization of the imine.

Course: CHEM 4983

Supervising Professor: James Johnson

Sheba John, 2009

The Effect of HDAC Inhibitors on the DNA Repair Kinetics in HMGN Null Cells

I will study the effect of HDAC inhibitors on the DNA repair kinetics in HMGN null cells.

Course: BIOL 4983

Supervising Professor: Michael Bergel

Cameron Story Perry, 2009

Carbon Dioxide Fixing Enzymes: A better way to reduce and sequester atmospheric CO2

I will research proteins, emphasizing non-plant proteins, which bind and use CO2.

Course: CHEM 4913

Supervising Professor: Mary Anderson

Elizabeth Tran, 2009

Phytochelatins: Biosynthesis, Cellular Mechanism of Plant Heavy Metal Detoxification, and Connection to Higher Eukaryotes

I will investigate what phytochelatins are, where they are found, what they do, how they are made, what other peptides they are like, and if there is any connection between phytochelatins and higher eukaryotes (humans}.

Course: CHEM 4983

Supervising Professor: Mary Anderson

Isabel Mojarro Lopez, 2008

Analysis of Lab Manuals for Physical Chemistry

I will analyze lab manuals for Physical Chemistry to create new projects that can be used in future Physical Chemistry classes.

Course: CHEM 3423

Supervising Professor: Lynda Peebles

Aungeleca Williams, 2007

Synthesis of a-Hydrazonyl Oximes

I will attempt to successfully synthesize an x-hydrazonyl oxime and then analyze the product.

Course: CHEM 4983

Supervising Professor: James Johnson

Melissa Bodnar, 2006

Equilibrium Thermodynamic Analysis of the Reversible, Heal-Induced Conformational Change in Lima Bean Trypsin Inhibitor by Differential Scanning Calorimetry

Lima Bean Trypsin Inhibitor (LBTI) will be studied, and measurements will be made of the reversible unfolding in lhe presence of guanidine hydrochloride.

Course: CHEM 4983

Supervising Professor: Mark Britt

Elizabeth Stockton, 2006

Characterization of the Polymorphic Composition of a Pharmaceutical: Chloropropamide AND Scratch and Wear Resistance of Novel Nano Composite Materials Used as Dental Replacements

I will determine the degree of polymorphism in chloropropamide pharmaceuticals by differential scanning calorimetry and study the scratch and wear resistance of nano composites used as dental replacements.

Course: CHEM 4913

Supervising Professor: Bryan Bilyeu

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