From Descartes’s Discourse on Method (1637):

Extract from Part 2 [The Principal Rules of the Method]:

“The first was never to accept anything for true which I did not clearly know to be such; that is to say, carefully to avoid precipitancy and prejudice, and to comprise nothing more in my judgement than what was presented to my mind so clearly and distinctly as to exclude all ground of doubt.

The second, to divide each of the difficulties under examination into as many parts as possible, and as might be necessary for its adequate solution.

The third, to conduct my thoughts in such order that, by commencing with objects the simplest and easiest to know, I might ascend by little and little, and, as it were, step by step, to the knowledge of the more complex; assigning in thought a certain order even to those objects which in their own nature do not stand in a relation of antecedence and sequence.

And the last, in every case to make enumerations so complete, and reviews so general, that I might be assured that nothing was omitted.”

Descartes broke with scholarly tradition and published the Discourse in French (Discours de la méthode) , so as to reach a wider audience of those interested in the new philosophical challenges. Perhaps the most famous aphorism to come from the text is " Je pense, donc je suis" -- or, in the Latin version for an even wider scholarly audience, "Cogito ergo sum." Usually translated as "I think, therefore I am," it was meant as a statement of a first principle. Self-awareness of doubting and thinking was the foundation of for the certainty of attaining knowledge, despite doubt about the fallible senses. [Or, go to the Monty Python version of philosophy in "Bruces' Philosophers Song" © 1989 ]

Extract from Part 6 [Some Prerequisites for Further Advances in the Study of Nature]:

"Thereupon, turning over in my mind I the objects that had ever been presented to my senses I freely venture to state that I have never observed any which I could not satisfactorily explain by the principles had discovered. But it is necessary also to confess that the power of nature is so ample and vast, and these principles so simple and general, that I have hardly observed a single particular effect which I cannot at once recognize as capable of being deduced in many different modes from the principles, and that my greatest difficulty usually is to discover in which of these modes the effect is dependent upon them; for out of this difficulty I cannot otherwise extricate myself than by again seeking certain experiments, which may be such that their result is not the same, if it is in the one of these modes at we must explain it, as it would be if it were to be explained in the other. "

Descartes recognized the power of deducing from principles, but also was aware that more than one conclusion can be drawn from partial knowledge. His solution was to imagine the new experiment as a test that would make different predictions for the alternative hypotheses.

Extract from Part 5 [Some Questions of Physics]:

Accepting a mechanical view of the body's organs and their functions --

"But lest those who are ignorant of the force of mathematical demonstrations and who are not accustomed to distinguish true reasons from mere verisimilitudes, should venture. without examination, to deny what has been said, I wish it to be considered that the motion [of the heart and blood, following Harvey] which I have now explained follows as necessarily from the very arrangement of the parts, which may be observed in the heart by the eye alone, and from the heat which may be felt with the fingers, and from the nature of the blood as learned from experience, as does the motion of a clock from the power, the situation, and shape of its counterweights and wheels. "

"I had shown what must be the fabric of the nerves and muscles of the human body to give the animal spirits contained in it the power to move the members . . . distributing the animal spirits through the muscles, can cause the members of such a body to move in as many different ways, and in a manner as suited, whether to the objects that are presented to its senses or to its internal affections, as can take place in our own case apart from the guidance of the will. Nor will this appear at all strange to those who are acquainted with the variety of movements performed by the different automata, or moving machines fabricated by human industry, and that with help of but few pieces compared with the great multitude of bones, muscles, nerves, arteries, veins, and other parts that are found in the body of each animal. Such persons will look upon this body as a machine made by the hands of God, which is incomparably better arranged, and adequate to movements more admirable than is any machine of human invention. "

Animal and human bodies are both intricate machines, but humans are still distinctive in their possession of reason and language --

"And here I specially stayed to show that, were there such machines exactly resembling organs and outward form an ape or any other irrational animal, we could have no means of knowing that they were in any respect of a different nature from these animals; but if there were machines bearing the image of our bodies, and capable of imitating our actions as far as it is morally possible, there would still remain two most certain tests whereby to know that they were not therefore really men. Of these the first is that they could never use words or other signs arranged in such a manner as is competent to us in order to declare our thoughts to others: for we may easily conceive a machine to be so constructed that it emits vocables, and even that it emits some correspondent to the action upon it of external objects which cause a change in its organs; for example, if touched in a particular place it may demand what we wish to say to it; if in another it may cry out that it is hurt, and such like; but not that it should arrange them variously so as appositely to reply to what is said in its presence, as men of the lowest grade of intellect can do. The second test is, that although such machines might execute many things with equal or perhaps greater perfection than any of us, they would, without doubt, fail in certain others from which it could be discovered that they did not act from knowledge, but solely from the disposition of their organs: for while reason is an universal instrument that is alike available on every occasion, these organs, on the contrary, need a particular arrangement for each particular action; whence it must be morally impossible that there should exist in any machine a diversity of organs sufficient to enable it to act in all the occurrences of life, in the way in which our reason enables us to act. Again, by means of these two tests we may likewise know the difference between men and brutes."

This ultimately preserves the special nature of humanity, and rejects atheistical materialism, by humanity's unique possession of the soul --

"I had after this described the reasonable [rational] soul, and shown that it could by no means be educed from the power of matter, as the other things of which I had spoken, but that it must be expressly created; and that it is not sufficient that it be lodged in the human body exactly like a pilot in a ship, unless perhaps to move its members, but that it is necessary for it to be joined and united more closely to the body, in order to have sensations and appetites similar to ours, and thus constitute a real man. I here entered, in conclusion, upon the subject of the soul at considerable length, because it is of the greatest moment: for after the error of those who deny the existence of God, an error which I think I have already sufficiently refuted, there is none that is more powerful in leading feeble minds astray from the straight path of virtue than the supposition that the soul of the brutes is of the same nature with our own; and consequently that after this life we have nothing to hope for or fear, more than flies and ants; in place of which, when we know how far they differ we much better comprehend the reasons which establish that the soul is of a nature wholly independent of the body, and that consequently it is not liable to die with the latter and, finally, because no other causes are observed capable of destroying it, we are naturally led thence to judge that it is immortal. "