Dr. Vieira Geraldo

Focused on the investigation of the non-coding RNAs, mainly microRNAs and long non coding RNAs, on the modulation of key signaling pathways for cancer development and progression. We combine large analysis of gene expression and computational approaches with in vitro and in vivo functional analysis to unveil the implicante of ncRNAs in cancer diagnosis and therapy.

MicroRNAs, small non-coding RNAs involved in post-transcriptional regulation of gene expression, are downregulated in papillary thyroid cancer. We use genomics, microTranscriptomics and bioinformatics analyses to identify microRNAs with key role in cancer, for subsequent in vitro and in vivo functional tests. We expect to shed light on the biological role of microRNAs from the DLK1-DIO3 region in thyroid follicular cell and their contribution to thyroid oncogenesis. We believe that the combination of different research strategies may significantly impact basic and translational thyroid-related research and contribute to the early detection and effective treatment of aggressive thyroid cancer.