Stephen Doyle is a molecular and computational biologist focused on understanding the evolutionary biology of parasitic worms that infect humans and animals. He leads a multidisciplinary research group at the Wellcome Sanger Institute near Cambridge, UK, that uses population-wide to single-cell resolution genomic approaches to understand the genetic mechanisms and phenotypic traits underpinning parasite adaptation and persistence.
Using a combination of in vivo models and parasites sampled from endemic countries worldwide, we measure and analyse helminth diversity across space and time, build genomic resources to support global parasitology communities, and develop genetic approaches to diagnose and surveil helminths. Collectively, this research aims to inform the sustainable and effective control of helminths to improve human and animal health.