RAD-140 for Sale

RAD 140 Effects on Animal Body Mass

RAD 140 SARM, or (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile, also known as testolone was originally synthesized for Radius Health Inc. in conjunction with researchers from the University of Illinois, Obiter Research, and Cambridge Major Laboratories.

Per the initial paper detailing the synthesis and preliminary findings of the compound, RAD140 has the stability to (t1/2 >2 h) in incubations with rat and monkey microsomes, as well as a high affinity for the androgen receptor (Ki = 7 nM), approximately 4 times the affinity than that of testosterone itself. At the same time, the nearest hormone receptor activated by RAD140 was progesterone at a level of 750nM.

The earliest primate studies on RAD-140 indicated that even at the lowest dose range 0.1mg/kg, juvenile macaques gained a mean of ten percent in body weight, during the 28-day trial period, which was primarily confirmed to be lean body mass via DEXA scans performed before and after the trial period, however, this was somewhat variable.

RAD 140 Effects on Neurons

In a study conducted by Jayaraman et. Al, gonadectomized, male rats were studied to see the effects supplementation with RAD 140 had in regards to neuroprotection in order to make conclusions regarding the usefulness of SARMs against neurodegenerative disorders.

The rats were orally provided with 1 mg/kg a day of RAD 140 for 2 weeks. It was found that RAD140 was able to reduce apoptosis caused by Aᵝ, apoptosis activator II, and hydrogen peroxide by a significant amount. This is due to the role MAPK signaling plays in neuroprotection.

Aᵝ was by far the most potent of the apoptosis insults introduced to the rats. After 24 hours of exposure to Aᵝ, 50% of viable neurons in the rats had decreased, however, when given RAD 140 in a concentration-dependent matter, the viability of the neurons had increased exponentially. The most effective concentration of RAD 140 was 100 nM, which led to approximately 90% neuron survival after Aᵝ exposure (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).

In addition to measuring the neuroprotection against various apoptosis insults, researchers also measured the effects RAD 140 had on kainate-induced neuron death. It was found that when compared to treatment with a vehicle, kainate-induced neuron death was significantly reduced (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).

Our compounds are available in powdered, poly-cell, and standard polyethylene glycol formulations. We employ an amphiphilic copolymer to form polymeric micelles that enhance the bioavailability of select SARMs In animal models.

Furthermore, our nano-emulsification process ensures minimum polymeric micelle size and variance. Most importantly, our Poly-Cell FormulaTM is optimized for sublingual absorption with a minimal taste profile. This stands in contrast to PEG, which is often intolerable for sublingual delivery due to its very unpleasant taste, leading to poor compliance among research participants. However, we do offer PEG for researchers who prefer the standard research delivery method.

The primary concern for SARM researchers today is product purity. Umbrella Labs insures and guarantees its product purity by incorporating a process of Independent testing using Mass Spectrometry and Ultraviolet Radiation. Certificates of our product Independent tests are posted with our product descriptions. Not only are our products guaranteed pure, but they are also guaranteed to be accurately concentrated as well.

**LAB USE ONLY**

*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).