PT-141, also known as Bremelanotide, is a peptide that has been shown to have positive effects on rats and primates in helping erectile dysfunction and various other forms of sexual dysfunction. Bremelanotide is shown to be an agonist at melanocortin receptors such as MC3R and MC4R and is also considered to be a melanocyte-stimulating hormone that is an active metabolite of Melanotan II. Various studies have begun to show how melanocortins have the ability to positively or negatively affect sexual health.
Bremelanotide is derived from the peptide hormone, melanotan II. It was originally recognized that melanocyte receptor stimulators play a role in sexual behavior in the 60s when research showed that the introduction of these receptors caused arousal in male rats. From there, researchers developed analogs such as melanton I and II. Melanotan II was further specialized and reduced into the derivative Bremelanotide. Bremelanotide is meant to bind to MC3R and MC4R has been shown to increase levels of arousal in both male and female rodents through the nervous system rather than the circulatory system (https://vitality-sciences.com/peptides/pt-141-erectile-dysfunction/).