ACP-105 is a selective androgen modulator receptor that has been known to affect deficient levels of various androgen receptors. Various studies examine male and female mice in order to determine the effects of ACP-105.
In an experiment conducted by Dayger et. Al, female mice underwent radiation due to the fact that in comparison to male mice, female mice reportedly experience a greater degree of cognitive decline. The study showed that two weeks after radiation exposure, ACP-105 supplementation was able to decrease the development of defects within the sensorimotor cortex.
Furthermore, following radiation exposure, the researchers found that by dosing the mice with ACP-105, there was decreased immunoreactivity of the MAP-2 protein. Dayger et. Al were able to use the collected data to come to the conclusion that because of decreased MAP-2 levels in the sensorimotor cortex, ACP-105 supplementation has the potential to enhance performance when a rotarod test is conducted on the mice (https://pubmed.ncbi.nlm.nih.gov/21219889/).