Sermorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) and prompts the release of Growth Hormone (GH) from the anterior pituitary gland. Sermorelin is clinically referred to as (GHR)1-29 NH2 indicating that the amino terminus is found at the 29th position. However, in clinical settings sermorelin is not used as a free base, but rather as an acetic acid salt. Treatment with sermorelin has been shown to increase serum concentration levels of GH and insulin-like growth factor (IGF-1).
Without supplementation of sermorelin, there are existing positive and negative feedback loops regulating the secretion of GH and somatostatin. This in turn creates a cycle similar to a circadian rhythm of GH secretion. With supplementation of sermorelin, the amplitude and frequency of GH secretion are drastically improved.