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Umbrella Labs
  • Home
    • Sarms for Sale
      • 5-ALPHA-HYDROXY LAXOGENIN for Sale
      • ACP 105 for Sale
      • LGD-4033 for Sale
      • MK-2866 for Sale
      • MK-677 for Sale
      • OTR-AC for Sale
      • RU58841 for Sale
      • S-23 for Sale
      • S-4 for Sale
      • SR-9009 for Sale
      • SR-9011 for Sale
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    • Peptides for Sale
      • PEPTIDE LIQUID SPRAY BOTTLE
      • ACE-031 PEPTIDE for Sale
      • ADAMAX PEPTIDE for Sale
      • ADIPOTIDE PEPTIDE for Sale
      • ALPHA MSH PEPTIDE for Sale
      • AOD9604 PEPTIDE for Sale
      • BACTERIOSTATIC WATER for Sale
      • BPC-157 PEPTIDE for Sale
      • CJC-1295 DAC PEPTIDE for Sale
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      • DSIP PEPTIDE for Sale
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      • FOLLISTATIN 344 FST-344 for Sale
      • FRAGMENT 176-191 PEPTIDE for Sale
      • GHK-CU COPPER PEPTIDE for Sale
      • GHRP-2 PEPTIDE (GROWTH HORMONE RELEASING PEPTIDE for Sale
      • VIP PEPTIDE for Sale
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      • PE22.28 PEPTIDE for Sale
      • MOTS-C PEPTIDE for Sale
      • LL-37 PEPTIDE for Sale
      • THYMALIN PEPTIDE for Sale
      • TRIPTORELIN PEPTIDE for Sale
      • SNAP-8 PEPTIDE for Sale
      • TESAMORELIN PEPTIDE for Sale
      • PEG-MGF PEPTIDE for Sale
      • IGF-1 DES PEPTIDE for Sale
      • P21 PEPTIDE LIQUID SPRAY for Sale
      • SERMORELIN PEPTIDE for Sale
      • GONADORELIN PEPTIDE for Sale
      • MELANOTAN II PEPTIDE for Sale
      • HEXARELIN PEPTIDE for Sale
      • MODIFIED GRF (1-29) PEPTIDE for Sale
      • OXYTOCIN PEPTIDE LIQUID SPRAY for Sale
      • SELANK PEPTIDE LIQUID SPRAY for Sale
      • IGF-1 LR3 PEPTIDE for Sale
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    • Nootropics
      • 5-HTP for Sale
      • 7,8-DIHYDROXYFLAVONE HYDRATE (DHT) for Sale
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      • ACETYL L-CARNITINE (ALCAR) for Sale
      • ADRAFINIL for Sale
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      • ANIRACETAM for Sale
      • BEMETHYL for Sale
      • BROMANTANE
      • CB-03-01 for Sale
      • CITICOLINE (CDP-CHOLINE) for Sale
      • COLURACETAM for Sale
      • COMPOUND 7P for Sale
      • D-RIBOSE for Sale
      • PHENYLPIRACETAM for Sale
      • NOOPEPT GVS-111 for Sale
      • FLADRAFINIL (CRL-40,941) for Sale
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      • TURKESTERONE 20% for Sale
      • PHENYLPIRACETAM HYDRAZIDE for Sale
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      • URIDINE MONOPHOSPHATE for Sale
      • NSI-189 PHOSPHATE for Sale
      • L-THEANINE for Sale
      • LAXOGENIN for Sale
      • PRL-8-53 for Sale
      • J147 for Sale
      • PHOSPHATIDYLSERINE for Sale
      • NMN (NICOTINAMIDE MONONUCLEOTIDE) for Sale
      • N-ACETYL L-TYROSINE (NALT) for Sale
      • L-TYROSINE for Sale
      • MAGNOLOL 98% MAGNOLIA BARK EXTRACT for Sale
      • KX-826 for Sale
      • WAY 316606 for Sale
      • N-PHENETHYL DIMETHYLAMINE (10 GRAMS) for Sale
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    • Lab Supplies
      • 1mL Pipette Dropper for Sale
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      • 10mg – 15mg Micro Scoop for Sale
      • 25mg – 30mg Micro Scoop for Sale
      • 150mg Micro Scoop for Sale
      • 30mL (1oz) Glass Bottle for Sale
      • 30mL Bottle w 1mL Dropper for Sale
      • 500mg (0.5g) Micro Scoop for Sale
      • Micro Scoops Variety Pack for Sale
    • Research Chemicals for Sale
      • RU58841 SOLUTION (SARM SUPPORT) for Sale
      • RU58841 POWDER (SARM SUPPORT) for Sale
  • More
    • Home
      • Sarms for Sale
        • 5-ALPHA-HYDROXY LAXOGENIN for Sale
        • ACP 105 for Sale
        • LGD-4033 for Sale
        • MK-2866 for Sale
        • MK-677 for Sale
        • OTR-AC for Sale
        • RU58841 for Sale
        • S-23 for Sale
        • S-4 for Sale
        • SR-9009 for Sale
        • SR-9011 for Sale
        • YK-11 for Sale
        • GW 0742 for Sale
        • RAD-140 for Sale
        • GW-501516 for sale
        • RAD-150 for Sale
        • LGD-3303 for Sale
      • Peptides for Sale
        • PEPTIDE LIQUID SPRAY BOTTLE
        • ACE-031 PEPTIDE for Sale
        • ADAMAX PEPTIDE for Sale
        • ADIPOTIDE PEPTIDE for Sale
        • ALPHA MSH PEPTIDE for Sale
        • AOD9604 PEPTIDE for Sale
        • BACTERIOSTATIC WATER for Sale
        • BPC-157 PEPTIDE for Sale
        • CJC-1295 DAC PEPTIDE for Sale
        • CJC-1295 NO DAC PEPTIDE for Sale
        • DSIP PEPTIDE for Sale
        • EPITALON PEPTIDE for Sale
        • FOLLISTATIN 344 FST-344 for Sale
        • FRAGMENT 176-191 PEPTIDE for Sale
        • GHK-CU COPPER PEPTIDE for Sale
        • GHRP-2 PEPTIDE (GROWTH HORMONE RELEASING PEPTIDE for Sale
        • VIP PEPTIDE for Sale
        • KPV PEPTIDE for Sale
        • PE22.28 PEPTIDE for Sale
        • MOTS-C PEPTIDE for Sale
        • LL-37 PEPTIDE for Sale
        • THYMALIN PEPTIDE for Sale
        • TRIPTORELIN PEPTIDE for Sale
        • SNAP-8 PEPTIDE for Sale
        • TESAMORELIN PEPTIDE for Sale
        • PEG-MGF PEPTIDE for Sale
        • IGF-1 DES PEPTIDE for Sale
        • P21 PEPTIDE LIQUID SPRAY for Sale
        • SERMORELIN PEPTIDE for Sale
        • GONADORELIN PEPTIDE for Sale
        • MELANOTAN II PEPTIDE for Sale
        • HEXARELIN PEPTIDE for Sale
        • MODIFIED GRF (1-29) PEPTIDE for Sale
        • OXYTOCIN PEPTIDE LIQUID SPRAY for Sale
        • SELANK PEPTIDE LIQUID SPRAY for Sale
        • IGF-1 LR3 PEPTIDE for Sale
        • SEMAX PEPTIDE LIQUID SPRAY for Sale
        • GHRP-6 PEPTIDE (GROWTH HORMONE RELEASING PEPTIDE 6) for Sale
        • IPAMORELIN PEPTIDE for Sale
        • MGF MECHANO GROWTH FACTOR PEPTIDE for Sale
        • PT-141 BREMELANOTIDE PEPTIDE for Sale
        • TB-500 THYMOSIN BETA-4 PEPTIDE for Sale
      • Nootropics
        • 5-HTP for Sale
        • 7,8-DIHYDROXYFLAVONE HYDRATE (DHT) for Sale
        • 9-ME-BC for Sale
        • ACA for Sale
        • ACETYL L-CARNITINE (ALCAR) for Sale
        • ADRAFINIL for Sale
        • AGOMELATINE for Sale
        • ALPHA-GPC for Sale
        • ANIRACETAM for Sale
        • BEMETHYL for Sale
        • BROMANTANE
        • CB-03-01 for Sale
        • CITICOLINE (CDP-CHOLINE) for Sale
        • COLURACETAM for Sale
        • COMPOUND 7P for Sale
        • D-RIBOSE for Sale
        • PHENYLPIRACETAM for Sale
        • NOOPEPT GVS-111 for Sale
        • FLADRAFINIL (CRL-40,941) for Sale
        • PRAMIRACETAM for Sale
        • TURKESTERONE 20% for Sale
        • PHENYLPIRACETAM HYDRAZIDE for Sale
        • FASORACETAM for Sale
        • NRC NIAGEN for Sale
        • IDRA-21 for Sale
        • SULBUTIAMINE for Sale
        • SPERMIDINE 3HCL for Sale
        • URIDINE MONOPHOSPHATE for Sale
        • NSI-189 PHOSPHATE for Sale
        • L-THEANINE for Sale
        • LAXOGENIN for Sale
        • PRL-8-53 for Sale
        • J147 for Sale
        • PHOSPHATIDYLSERINE for Sale
        • NMN (NICOTINAMIDE MONONUCLEOTIDE) for Sale
        • N-ACETYL L-TYROSINE (NALT) for Sale
        • L-TYROSINE for Sale
        • MAGNOLOL 98% MAGNOLIA BARK EXTRACT for Sale
        • KX-826 for Sale
        • WAY 316606 for Sale
        • N-PHENETHYL DIMETHYLAMINE (10 GRAMS) for Sale
        • NEFIRACETAM for Sale
        • VINPOCETINE for Sale
      • Lab Supplies
        • 1mL Pipette Dropper for Sale
        • 6mg – 10mg Micro Scoop for Sale
        • 10mg – 15mg Micro Scoop for Sale
        • 25mg – 30mg Micro Scoop for Sale
        • 150mg Micro Scoop for Sale
        • 30mL (1oz) Glass Bottle for Sale
        • 30mL Bottle w 1mL Dropper for Sale
        • 500mg (0.5g) Micro Scoop for Sale
        • Micro Scoops Variety Pack for Sale
      • Research Chemicals for Sale
        • RU58841 SOLUTION (SARM SUPPORT) for Sale
        • RU58841 POWDER (SARM SUPPORT) for Sale

MK-677 for Sale

MK-677 is a long-acting, ghrelin receptor agonist and Human Growth Hormone stimulator, spiroindoline sulfonamide. It is also known as Ibutamoren, MK-677, L-163, 191, and formerly known as Oratrope.

In a study performed by Jacks et. Al published in Endocrinology in 199g, 8 beagles were given MK-677 at doses of 0.25mg/kg, and it was found that Growth Hormone (GH) levels increased 5.3 times over baseline. At the 0.5mg/kg dose, GH levels increased 9 times over baseline GH rates, and at the 1mg/kg dose range, the GH levels increased by nearly 16 times that of baseline (15.8). It’s important to note that these doses were oral vs. intravenous or intramuscular injection.

Insulin-like growth factor remained elevated by 30% after 8 hours, indicating MK-677 is a long-acting compound in beagles. GH was also elevated up to 6 hours. Study authors mentioned that cortisol was also elevated, however, it was modest compared to those in GH.

But MK-677 is not just a GH secretagogue, it is also an orally active gherkin receptor agonist, meaning it will work on the ghrelin receptors.

As explained by Zhang et al, “The ‘hunger hormone’ ghrelin activates the ghrelin receptor GHSR to stimulate food intake and growth hormone secretion and regulate reward signaling.”

In addition to its role in hunger signaling, it also modulates stress, glucose, body weight, cognition, gut motility, the desire for food, adiposity, and even pain.

An extensive study of MK-677’s chemical makeup in relation to ghrelin itself by Zhang’s research group discovered that MK-677 (termed Ibutamoren by their study), “mimics the first four N-terminal residues of ghrelin including the octanoyl moiety to bind at the bottom region of the ligand-binding pocket.” https://assets.researchsquare.com/files/rs-646701/v1_covered.pdf?c=1631873382

If interested in the many target organs of ghrelin, see the following image at the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343809/figure/ijms-18-00273-f001/

An interesting impact of MK-0677 on the ghrelin agonist that stimulates the GHS-R1a receptor has been shown to increase neural activity and decrease the death of neurons and neuroinflammation. In a study published in the International Journal of Molecular Sciences, researchers Jeong et. al, gave MK-677 to mice who were genetically predisposed to overexpress amyloid beta-peptide or Aβ, a protein responsible for the plaques and tangles shown in Alzheimer’s diseased brains.

These mice were given MK-0677 via injection, at dose levels of 0.1, 1, and 3mg/kg for ten days.

The second two groups had increased food intake through the ten-day study period, especially at the 3mg/kg dosing level. However, at the end of the ten days, body weight did not significantly differ between all dosing groups.

Examination of the brains of the treated groups showed decreased Aβ deposition and decreased neuronal, synaptic losses as well as glial changes in the deep cortical layers of the brain. Researchers concluded that MK-677 also reduced the neuroinflammation and neurodegeneration associated with Aβ.

https://www.mdpi.com/1422-0067/19/6/1800/htm

The primary concern for SARM researchers today is product purity. Umbrella Labs insures and guarantees its product purity by incorporating a process of Independent testing using Mass Spectrometry and Ultraviolet Radiation. Certificates of our product Independent tests are posted with our product descriptions.

Shipping Conditions: Ambient temperature.

Storage: Keep in a cool and dark location.


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