96)

“Structural revision of natural cyclic depsipeptide MA026 established by total synthesis and biosynthetic gene cluster analysis.” Uchiyama C, Fukuda A, Mukaiyama M, Nakazawa Y, Kuramochi Y, Muguruma K, Arimoto M, Ninomiya A, Kako K, Katsuyama Y, Konno S, Taguchi A, Takayama K, Taniguchi A, Nagumo Y, Usui T, Hayashi Y. Angew. Chem. Int. Ed., 60, 8792-8797 (2021). 10.1002/anie.202015193

95)

“Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid-Selective Adenylation Enzyme HitB.” Kudo F, Takahashi S, Miyanaga A, Nakazawa Y, Nishino K, Hayakawa Y, Kawamura K, Ishikawa F, Tanabe G, Iwai N, Nagumo Y, Usui T, Eguchi T. ACS Chem. Biol., 16, 539-547 (2021). 10.1021/acschembio.1c00003.

94)

“Dual inhibition of γ-tubulin and Plk1 induces mitotic cell death.” Ebisu H, Shintani K, Chinen T, Nagumo Y, Shioda S, Hatanaka T, Sakakura A, Hayakawa I, Kigoshi H, and Usui T. Front. Pharmacol., 11, 620185 (2021). 10.3389/fphar.2020.620185

93)

“A novel translation inhibitor, mersicarpine, inhibits S-phase progression and induces apoptosis in HL60 cells.” Shiobara T, Nagumo Y, Nakajima R, Fukuyama T, Yokoshima S, and Usui T. Biosci. Biotechnol. Biochem., 85, 92-96 (2021). 10.1093/bbb/zbaa070

92)

“Non-electrophilic TRPA1 agonists, menthol, carvacrol and clotrimazole, open epithelial tight junctions via TRPA1 activation.” Mukaiyama M, UsuiT, and Nagumo Y. J. Biochem. 168, 407-415 (2020). 10.1093/jb/mvaa057

91)

“Structure optimization of gatastatin for the development of γ-tubulin-specific inhibitor.” Shintani K, Ebisu H, Mukaiyama M, Hatanaka T, Chinen T, Takao D, Nagumo Y, Sakakura A, Hayakawa I, and UsuiT. ACS Med. Chem. Lett., 11(6), 1125-1129 (2020).

90)

“Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells.” Myobatake Y, Kamisuki S, Tsukuda S, Higashi T, Chinen T, Takemoto K, Hachisuka M, Suzuki Y, Takei M, Tsurukawa Y, Maekawa H, Takeuchi T, Matsunaga TM, Sahara H, Usui T, Matsunaga S, Sugawara F. Bioorg. Med. Chem., 27, 115149 (2019).

89)

“Transient receptor potential V4 channel stimulation induces reversible epithelial cell permeability in MDCK cell monolayers” Mukaiyama M, Yamasaki Y, Usui T, and Nagumo Y. FEBS Lett., 593, 2250-2260 (2019)

88)

“Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast.” Hamada K, Naito A, Hamaguchi Y, Kasahara K, Taguchi A, Omura N, Hayashi Y, and Usui T. Biosci. Biotechnol. Biochem., 83, 1889-1892 (2019).

87)

“Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae.” Sakai K, Unten Y, Iwatsuki M, Matsuo H, Fukasawa W, Hirose T, Chinen T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Murai M, Miyoshi H, Asami Y, Ōmura S, and Shiomi K. J. Antibiot., 72, 645-652 (2019).

86)

“Structure–activity relationship study of gatastatin based on the topliss tree approach.” Hayakawa I, Shioda S, Chinen T, Usui T, and Kigoshi H. Heterocycles, 99 (1), 238-247 (2019). DOI: 10.3987/COM-18-S(F)16

85)

“Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus.” Sakai K, Suga T, Iwatsuki M, Chinen T, Nonaka K, Usui T, Asami Y, Omura S, Shiomi K. J. Antibiot., 71, 1031–1035 (2018).

84)

“Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay.” Sakai K, Hirose T, Iwatsuki M, Chinen T, Kimura T, Suga T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Asami Y, Omura S, Shiomi K. J. Nat. Prod., 81, 1604-1609 (2018)

83)

"TRPA1-dependent reversible opening of tight junction by natural compounds with α,β-unsaturated moiety and capsaicin." Kanda Y, Yamasaki Y, Sasaki-Yamaguchi Y, Ida-Koga N, Kamisuki S, Sugawara F, Nagumo Y, and Usui T. Sci. Rep., 8, 2251 (2018).

82)

"Structure-Activity Relationship Study of Leucyl-3-epi-Deoxynegamycin for Potent Premature Termination Codon Readthrough." Taguchi A, Hamada K, Shiozuka M, Kobayashi M, Murakami S, Takayama K, Taniguchi A, Usui T, Matsuda R, and Hayashi Y. ACS Med. Chem. Lett., 8, 1060-1065 (2017).

81)

"Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules." Semenova I, Gupta D, Usui T, Hayakawa I, Cowan A, and Rodionov V. Mol. Biol. Cell., 28, 1418-1425 (2017).

80）

"Structure-activity relationships of terpendole E and its natural derivatives." Nagumo Y, Motoyama T, Hayashi T, Hirota H, Aono H, Kawatani M, Osada h, and Usui T. ChemistrySelect., 2, 1533-1536 (2017).

79）

"MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane." Kanda Y, Yamasaki Y, Shimura S, Kamisuki S, Sugawara F, Nagumo Y, and Usui T. J. Antibiot., 70, 691-694 (2017).

This paper is dedicated to Professor Satoshi Omura, a distinguished Novel Prize awardee in Physiology or Medicine 2015.

78)

"Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate" Kanoh N, Mano K, Saegusa D, Usui T, and Iwabuchi Y. Bioorg. Med. Chem. Lett., 26, 5770-5772 (2016).

77)

"Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization" Hayakawa I, Shioda S, Chinen T, Hatanaka T, Ebisu H, Sakakura A, Usui T, and Kigoshi H. Bioorg. Med. Chem., 24, 5639-5645 (2016).

76)

"Eudistomin C, an antitumor and antiviral natural product, targets 40S ribosome and inhibits protein translation" Ota Y, Chinen T, Yoshida K, Kudo S, Nagumo Y, Shiwa Y, Yamada R, Umihara H, Iwasaki K, Masumoto H, Yokoshima S, Yoshikawa H, Fukuyama T, Kobayashi J, and Usui T. ChemBioChem, 17, 1616-1620 (2016)

75)

"Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line" Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, and Nagao M. Biochem. Biophys. Res. Commun., 477, 40-46 (2016)

74)

"Bafilomycin analogue site-specifically fluorinated at the pharmacophore macrolactone ring has potent vacuolar-type ATPase inhibitory activity" Tuchikawa H, Hayashi T, Shibata H, Murata M, Nagumo Y, and Usui T, Tetrahedron Lett., 57, 2426-2429 (2016)

73)

"Synthesis and structure-activity relationship study of FD891: Importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells" Itagaki T, Kawamata A, Takeuchi M, Hamada K, Iwabuchi Y, Eguchi T, Kudo F, Usui T, and Kanoh N. J. Antibiot., 69, 287-293 (2016)

72)

"Vicenistatin induces early endosome-derived vacuole formation in mammalian cells" Nishiyama Y, Ohmichi T, Kazami S, Iwasaki H, Mano K, Nagumo Y, Kudo F, Ichikawa S, Iwabuchi Y, Kanoh N, Eguchi T, Osada H, and Usui T Biosci. Biotechnol. Biochem., 80, 902-910 (2016)