48)

“Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.” Chinen T, Nagumo Y, Watanabe T, Imaizumi T, Shibuya M, Kataoka T, Kanoh N, Iwabuchi Y., and Usui T. Toxicol. Lett. 199, 341-346 (2010)

47)

“Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.” Ikedo A, Hayakawa I, Usui T, Kazami S, Osada H, Kigoshi H. Bioorg. Med. Chem. Lett. 20, 5402-5404 (2010)

46)

“Application of proteomic profiling based on 2-DIGE for classification of compounds according to the mechanism of action.” Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, and Osada H. Chem. Biol. 17,, 460-470 (2010)

45)

Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue.” Watanabe T, Imaizumi, T, Chinen T, Nagumo Y, Shibuya M, Usui T, Kanoh N, and Iwabuchi Y. Org. Lett. 12, 1040-1043 (2010)

44)

“The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells.” Inaba S, Eguchi T, Motegi A, Mizoue K, Usui T, Nagai K, and Kataoka T. J. Antibiot. 62, 507-512 (2009).

43)

“Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.” Kato N, Suzuki H, Tagagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, and Osada H. Chembiochem. 10, 920-928 (2009)

42)

“A cell-based screening to detect inhibitors of BRAF signaling pathway.” Asami Y, Mori M, Koshino H, Sekiyama Y, Teruya T, Simizu S, Usui T, and Osada H. J. Antibiot. 62, 105-107 (2009)

41)

“Effect of Dehydroaltenusin-C12 Derivative, a Selective DNA Polymerase ? Inhibitor, on DNA Replication in Cultured Cells.・h Kuriyama I, Mizuno T, Fukudome K, Kuramochi K, Tsubaki K, Usui T, Imamoto N, Sakaguchi K, Sugawara F, Yoshida H, and Mizushina Y. Molecules, 13, 2948-2961 (2008)

40)

“Synthesis and anti-angiogenic activity of coristatin analogs.” Sato Y, Kamiyama H, Usui T, Saito T, Osada H, Kuwahar a S, and Kiyota H. Biosci. Biotechnol. Biochem.,72, 2992-2997 (2008)

39)

“Synthesis and biological activities of reveromycin A and spirofungin A derivatives.” Shimizu T, Usui T, Fujikura M, Kawatani M, Satoh T, Machida K, Kanoh N, Woo JT, Osada H, and Sodeoka M. , 18, 3756-3760 (2008)

38)

“Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kB signaling by crosslinking TAK1.” Kamiyama H, Usui T, Sakurai H, Shoji M, Hayashi Y, Kakeya H, and Osada H. Biosci. Biotechnol. Biochem., 72, 1894-1900 (2008)

37)

“Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.” Kamiyama H, Usui T, Uramoto M, Takagi H, Shoji M, Hayashi Y, Kakeya H, and Osada H. J. Antibiot, 61, 94-97 (2008)

36)

“Epoxyquinol B shows antiantiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.” Kamiyama H, Kakeya H, Usui T, Nishikawa K, Shoji M, Hayashi Y, and Osada H. Oncol. Res. 17, 11-21 (2008).

35)

“Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells.” Yoshida M, Matsui Y, Ikarashi Y, Usui T, Osada H, and Wakasugi H. Anticancer Res. 27, 729-736 (2007).

34)

“Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.” Yokosuka A, Haraguchi M, Usui T, Kazami S, Osada H, Yamori T, and Mimaki Y. Bioorg. Med. Chem. Lett., 17, 3091-3094 (2007).

33)

“Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L.” Usui T, Nagumo Y, Watanabe A, Kubata T, Komatsu K, Kobayashi J, and Osada H. Chem. Biol., 13, 1153-1160 (2006).

This paper was selected as "Faculty 1000"

32)

“Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin.” Uchimura S, Oguchi Y, Katsuki M, Usui T, Osada H, Nikawa J, Ishiwata S, and Muto E. EMBO J., 25, 5932-5941 (2006).

31)

“Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.” Okumura H, Nakazawa J, Tsuganezawa K, Usui T, Osada H, Matsumoto T, Tanaka A, and Yokoyama S. Toxicol. Lett., 166, 44-52 (2006).

30)

“Iejimalides shows anti-osteoclast activity via V-ATPase inhibition.” Kazami S, Muroi M, Kawatani M, Kubota T, Usui T, Kobayashi J, and Osada H. Biosci. Biotechnol. Biochem., 70, 1364-1370 (2006).

This paper was selected as "The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry"