71)

"Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B" Uesugi S, Watanabe T, Imaizumi T, Ota Y, Yoshida K, Ebisu H, Chinen T, Nagumo Y, Shibuya M, Kanoh N, Usui T, and Iwabuchi Y. J. Org. Chem., 80, 12333-12350 (2015)

70)

"The γ-tubulin specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle" Chinen T, Liu P, Shioda S, Pagel J, Cerikan B, Lin T, Gruss O, Hayashi Y, Takeno H, Shima T, Okada T, Hayakawa I, Hayashi Y, Kigoshi H, Usui T, and Schiebel E. Nat. Commun., 6, 8722 (2015) DOI: 10.1038/ncomms9722.

69)

"Irciniastatin A induces a potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of TNF receptor 1 in human lung carcinoma A549 cells" Quach H.T., Hirano S, Fukuhara S, Watanabe T, Kanoh N, Iwabuchi Y, Usui T, and Kataoka T. Biol. Pharm. Bull., 38, 941-946 (2015).

68)

"Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation" Iida A, Usui T, Zar Kalai F, Han J, Isoda H, and Nagumo Y. Biosci. Biotechnol. Biochem., 79, 1548-1551 (2015).

67)

“Modification of bafilomycin structure to efficiently synthesize solid-state NMR probes that selectively bind to vacuolar-type ATPase” Shibata H, Tsuchikawa H, Hayashi T, Matsumori N, Murata M, and Usui T. Chemistry - An Asian Journal, 10, 915-924 (2015).

66)

“Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1” Hirano S, Quach H, Watanabe T, Kanoh N, Iwabuchi Y, Usui T, and Kataoka T. J. Antibiot., 68, 417-420 (2015).

65)

“Iejimalide C is a potent V-ATPase inhibitor, and induces actin disorganization” Kazami S, Takaine M, Itoh H, Kubota T, Kobayashi J, and Usui T. Biol. Pharm. Bull., 37, 1944-1947 (2014)

64)

“Development of A New Benzophenone-Diketopiperazine-Type Potent Anti-Microtubule Agent Possessing a 2-Pyridine Structure” Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, and Hayashi Y. ACS Med. Chem. Lett., 5, 1094-1098 (2014)

63)

“Discovery of Natural Products Possessing Selective Eukaryotic Readthrough Activity: 3-epi-Deoxynegamycin and Its Leucine Adduct” Taguchi A, Hamada K, Kotake M, Shiozuka M, Nakaminami H, Pillaiyar T, Takayama K, Yakushiji F, Noguchi N, Usui T, Matsuda R, and Hayashi Y. ChemMedChem, 9, 2233-2237 (2014)

62)

“Bafilomycin L, a New Inhibitor of Cholesteryl Ester Synthesis in Mammalian Cells, Produced by Marine-derived Streptomyces sp. OPMA00072” Kobayashi K, Fukuda T, Usui T, Kurihara Y, Kanamoto A, and Tomoda H. J. Antibiot., 68, 126-132 (2015).

61)

“Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system” Chinen T, Nagumo Y, and Usui T. J. Gen. Appl. Microbiol., 60, 160-162 (2014).

60)

"Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5” Tarui Y, Chinen T, Nagumo Y, Motoyama T, Hayashi T, Hirota H, Muroi M, Ishii Y, Kondo H, Osada H. and Usui T. ChemBioChem, 15, 934-938 (2014)

59)

"Design and synthesis of 24-fluorinated bafilomycin analogue as an NMR probe with potent inhibitory activity to vacuolar-type ATPase” Shibata H, Tsuchikawa H, Matsumori N, Murata M, and Usui T. Chem Lett., 43, 474-476 (2014)

58)

"Inhibition of Microtubule Assembly by a Complex of Actin and Antitumor Macrolide Aplyronine A” Kita M, Hirayama Y, Yoneda K, Yamagishi K, Chinen T, Usui T, Sumiya E, Uesugi M, and Kigoshi H. J Am Chem Soc., 135, 18089-18095 (2013)

57)

"The Reversible Increase in Tight Junction Permeability Induced by Capsaicin is Mediated via Cofilin-Actin Cytoskeletal Dynamics and Decreased Level of Occludin” Shiobara T, Usui T, , Han J, Isoda H, and Nagumo Y. PLoS One, DOI:10.1371/journal.pone.0079954

56)

"Glaziovianin A Prevents Endosome Maturation via Inhibiting Microtubule Dynamics.” Chinen T, Kazami S, Nagumo Y, Hayakawa I, Ikedo A, Takagi M, Yokosuka A, Imamoto N, Mimaki Y, Kigoshi H, Osada H, and Usui T. ACS Chem Biol., 8, 884-889 (2013)

55)

“Synthesis and Structure-Activity Relationship of Vicenistatin, a Cytotoxic 20-Membered Macrolactam Glycoside” Fukuda H, Nishiyama Y, Nakamura S, Ohno Y, Eguchi T, Iwabuchi Y, Usui T, and Kanoh N. Chemistry - An Asian Journal, 7, 2872-2881 (2012)

54)

“Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone” Hayakawa I, Ikedo A, Chinen T, Usui T, and Kigoshi H. Bioorg. Med. Chem. 20, 5745-5756 (2012)

53)

“Synthesis and structure activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents” Yamazaki Y, Sumikura M, Masuda Y, Hayashi Y, Yasui H, Kiso Y, Chinen T, Usui T, Yakushiji F, Potts B, Neuteboom S, Palladino M, Lloyd GK, Hayashi Y.Bioorg. Med. Chem. 20, 4279-4289 (2012)

52)

“Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure” Yamazaki Y, Tanaka K, Nicholson B, Deyanat-Yazdi G, Potts B, Yoshida T, Oda A, Kitagawa T, Orikasa S, Kiso Y, Yasui H, Akamatsu M, Chinen T, Usui T, Shinozaki Y, Yakushiji F, Miller BR, Neuteboom S, Palladino M, Kanoh K, Lloyd GK, and Hayashi Y. J. Med. Chem. 55, 1056-1071 (2012)

51)

“Actin stress fiber retraction and aggresome formation is the common cellular response against actin toxins” Kazami S, Usui T, and Osada H. Biosci. Biotechnol. Biochem. 75, 1853-1855 (2011)

50)

“Construction of multidrug-sensitive yeast with high sporulation efficiency.” Chinen T, Ota Y, Nagumo Y, Masumoto H, and Usui T.Biosci. Biotechnol. Biochem. 75, 1588-1593 (2011)

This paper was selected as "The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry"

49)

“Microarray-based target identification using drug-hypersinsitive fission yeast expressing ORFeome.” Arita Y, Nishimura S, Matsuyama A, Yashiroda Y, Usui T, Boone C, and Yoshida M. Mol. Biosyst. 7, 1463-1472 (2011)