2021年以降の論文

110)

“The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene.” Honma S, Kimishima A, Kato S, Horiuchi A, Hokari R, Honsho M, Kojima H, Tokiwa T, Sugawara A, Iwatsuki M, Araki Y, Takahashi T, Chinen T, Usui T, Ito K, Asami Y. Bioorg Med Chem Lett. 113, 129947. doi: 10.1016/j.bmcl.2024.129947. 

109)

“Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers.” Kimishima A, Nishitomi A, Kondo N, Honma, S, Honsho M, Negami S, Maruyama S, Taguchi K, Matsui H, Hanaki H, Chinen T, Usui T, Ogasawara H, Asami Y. Biosci Biotechnol Biochem. 88(10), 1242-1246 (2024). doi: 10.1093/bbb/zbae103.

108)

“Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity.” Kimishima A, Nishitomi A, Tsuruoka I, Sakai K, Hokari R, Honsho M, Honma, S, Ohno Y, Kondo N, Tsutsumi H, Kikuchi Y, Tokiwa T, Kojima H, Higo M, Nonaka K, Inahashi Y, Iwatsuki M, Fuji S-I, Jang J-P, Jang, J-H, Chinen T, Usui T, Asami Y. Biosci Biotechnol Biochem. 88(10), 1212-1216 (2024). doi: 10.1093/bbb/zbae098.

107)

“Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates.” Kimishima A, Nishitomi A, Tsuruoka I, Honsho M, Negami S, Honma S, Sakai K, Tokiwa T, Kojima H, Nonaka K, Fuji SI, Chinen T, Usui T, Asami Y. J Pestic Sci, 49(3), 159-167 (2024). doi: 10.1584/jpestics.D24-014.

106)

“Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.” Honma S, Kimishima A, Kimishima A, Honsho M, Kojima H, Tokiwa T, Nishitomi A, Kato S, Kondo N, Araki Y, Takahashi T, Chinen T, Usui T, Fuji S, Ito K, Asami Y. Biosci Biotechnol Biochem. 88, 824-829 (2024). doi: 10.1093/bbb/zbae050.

105)

“Design, synthesis, and biological evaluation of new biaryl derivatives of cycloalkyl diacetamide bearing chalcone moiety as type II c-MET kinase inhibitors.” Salarinejad S, Seyfi S, Hayashi S, Moghimi S, Toolabi M, Taslimi P, Firoozpour L, Usui T, Foroumadi A. Mol Divers 28(6), 4167-4180 (2024). doi: 10.1007/s11030-024-10807-x.

104)

“Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi.” Kimishima A, Hagimoto D, Honsho M, Sakai K, Honma S, Fuji SI, Iwatsuki M, Tokiwa T, Nonaka K, Chinen T, Usui T, Asami Y. Org Lett. 26, 597-601 (2024). doi: 10.1021/acs.orglett.3c03792.

103)

“Capsaicin indirectly regulates TRPA1 via the arachidonic acid cascade, resulting in TJ opening.“ Kanda Y, Mukaiyama M, Yamasaki Y, Usui T, Nagumo Y. Biosci Biotechnol Biochem. 88, 44-52 (2024). doi: 10.1093/bbb/zbad145.

102)

“RSK4 confers while its inhibitor BI-D1870 overcomes resistance to paclitaxel in ovarian cancer cells.”, Nagumo Y, Villareal MO, Isoda H, Usui T. Biochem. Biophys Res Commun, 679, 23-30 (2023). doi: 10.1016/j.bbrc.2023.08.060.

101)

“X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener.” Mukaiyama M, Uchiyama C, Fukuda A, Nakazawa Y, Kuramochi Y, Shibata Y, Konno S, Muguruma K, Matsugaki N, Asari T, Ogawa K, Taguchi A, Takayama K, Taniguchi A, Nagumo Y, Senda T, Hayashi Y, Usui T. J Med Chem, 66, 8717-8724 (2023). doi: 10.1021/acs.jmedchem.3c00365. 

100)

“Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics.” Kudo F, Kishikawa K, Tsuboi K, Kido T, Usui T, Hashimoto J, Shin-Ya K, Miyanaga A, Eguchi T. Chembiochem e202200670. (2023). doi: 10.1002/cbic.202200670. 

99)

“A Combination Strategy of Multidrug-Sensitive Budding Yeast and Chemical Modifications Enabling to Find a New Overlooked Antifungal Compound, Sakurafusariene, from In-House Fractionated Library.” Kimishima A, Ono Y, Sakai K, Sakai K, Honsho M, Naher K, Tokiwa T, Kojima H, Higo M, Nonaka K, Iwatsuki M, Fuji SI, Chinen T, Usui T, Asami Y. J. Agric. Food Chem. 71, 3219–3224 (2023). doi: 10.1021/acs.jafc.2c09015.

98)

“High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds” Ohnuki S, Ogawa I, Itto-Nakama K, Lu F, Ranjan A, Kabbage M, Gebre AA, Yamashita M, Li SC, Yashiroda Y, Yoshida S, Usui T, Piotrowski JS, Andrews BJ, Boone C, Brown GW, Ralph J, Ohya Y. npj Syst Biol Appl 8, 3 (2022). https://doi.org/10.1038/s41540-022-00212-1

97)

“Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria” Sakai K, Unten Y, Kimishima A, Nonaka K, Chinen T, Sakai K, Usui T, Shiomi K, Iwatsuki M, Murai M, Miyoshi H, Asami Y, Ōmura S. J. Indust. Microbiol. Biotechnol. 48, kuab051 (2021). https://doi.org/10.1093/jimb/kuab051

96)

“Structural revision of natural cyclic depsipeptide MA026 established by total synthesis and biosynthetic gene cluster analysis.” Uchiyama C, Fukuda A, Mukaiyama M, Nakazawa Y, Kuramochi Y, Muguruma K, Arimoto M, Ninomiya A, Kako K, Katsuyama Y, Konno S, Taguchi A, Takayama K, Taniguchi A, Nagumo Y, Usui T, Hayashi Y. Angew. Chem. Int. Ed., 60, 8792-8797 (2021). 10.1002/anie.202015193

95)

“Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid-Selective Adenylation Enzyme HitB.” Kudo F, Takahashi S, Miyanaga A, Nakazawa Y, Nishino K, Hayakawa Y, Kawamura K, Ishikawa F, Tanabe G, Iwai N, Nagumo Y, Usui T, Eguchi T. ACS Chem. Biol., 16, 539-547 (2021). 10.1021/acschembio.1c00003. 

94)

“Dual inhibition of γ-tubulin and Plk1 induces mitotic cell death.” Ebisu H, Shintani K, Chinen T, Nagumo Y, Shioda S, Hatanaka T, Sakakura A, Hayakawa I, Kigoshi H, and Usui T. Front. Pharmacol., 11, 620185 (2021). 10.3389/fphar.2020.620185

93)

“A novel translation inhibitor, mersicarpine, inhibits S-phase progression and induces apoptosis in HL60 cells.” Shiobara T, Nagumo Y, Nakajima R, Fukuyama T, Yokoshima S, and Usui T. Biosci. Biotechnol. Biochem., 85, 92-96 (2021). 10.1093/bbb/zbaa070