29)

“Amphidinolide H, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.” Usui T, Kazami S, Dohmae N, Mashimo Y, Kondo H, Tsuda M, Terasaki GA, Ohashi K, Kobayashi J, and Osada H. Chem. Biol., 11, 1269-1277 (2004)

28)

“The anticancer natural product pironetin selectively targets Lys352 of α-tubulin.” Usui T, Watanabe H, Nakayama H, Tada Y, Kanoh N, Kondoh M, Asao T, Takio K, Watanabe H, Nishikawa K, Kitahara T, and Osada H. Chem. Biol., 11, 799-806 (2004)

27)

“The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage.” Usui T, Maekawa H, Pereira G, and Schiebel E. EMBO J., 22, 4779-4793 (2003).

26)

“Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions.” Maekawa H, Usui T, Knop M, and Schiebel E. EMBO J., 22, 438-449 (2003).

25)

“A novel action of terpendole e on the motor activity of mitotic Kinesin Eg5.” Nakazawa J, Yajima J, Usui T, Ueki M, Takatsuki A, Imoto M, Toyoshima YY, and Osada H. Chem. Biol., 10, 131-137 (2003).

24)

“Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.” Nakamura M, Nakazawa J, Usui T, Osada H, Kono Y, and Takatsuki A. Biosci. Biotechnol. Biochem., 67, 151-157 (2003).

23)

“Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.” Sirirath S, Tanaka J, Ohtani II, Ichiba T, Rachmat R, Ueda K, Usui T, Osada H, and Higa T. J. Nat. Prod., 65, 1820-1823 (2002).

22)

“Chemical modification of reveromycin A and its biological activities.” Shimizu T, Usui T, Machida K, Furuya K, Osada H, and Nakata T. Bioorg. Med. Chem. Lett., 12, 3363-3366 (2002).

21)

“Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.” Miyamoto Y, Machida K, Mizunuma M, Emoto Y, Sato N, Miyahara K, Hirata D, Usui T, Takahashi H, Osada H, and Miyakawa T. J. Biol. Chem., 277, 28810-28814 (2002)

20)

“4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.” Ueda K, Usui T, Nakayama H, Ueki M, Takio K, Ubukata M, and Osada H. FEBS Lett., 525, 48-52 (2002)

19)

“Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition.” Usui T, Kojima S, Kidokoro S, Ueda K, Osada H, and Sodeoka M. Chem. Biol., 8, 1209-1220 (2001)

18)

“Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition.” Sodeoka M, Sampe R, Kojima S, Baba Y, Usui T, Ueda K, and Osada H. J. Med. Chem., 44, 3216-3222 (2001).

17)

“Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.” Sano T, Usui T, Ueda K, Osada H, and Kaya K. J. Nat. Prod., 64, 1052-1055 (2001).