If the legends of long dead civilizations from millennia ago are to be believed, then the Dark Matter Plague was a incredibly virulent pathogen capable of existing and spreading beneath the quantum level and virtually impossible to contain or inoculate against. Stranger still, and considered by many to be the fanciful musing of long dead authors, is the suggestion that the Dark Matter Plague was also intelligent and purposefully malevolent. The practical interpretation from these apocryphal stories, is that the plague had a very high rate of mutation and was constantly adapting how it spread and how it eliminated its victims.

The disappearance of all previously spacefaring races in the ancient past, known colloquially as "the Sundering" is the best evidence that perhaps such a plague once existed and was somehow responsible for widespread galactic devastation, however, not all of these civilizations were destroyed by disease, several were clearly destroyed by wars and/or other less outlandish ecological disasters.

There exists no physical evidence of the Dark Matter Plague, but for some it holds a place in the imagination akin to the Terran "boogeyman" a specter of terror, wrath, and death.