SHIROUCHI LAB - Publications

Publications

(Last update: 2025/5/28)

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2025

NEW Shirouchi B*, Mitsuta S, Higuchi M, Okumura M, Tanaka K. Dietary nicotinamide mononucleotide, a key NAD+ intermediate, alleviates body fat mass and hypertriglyceridemia by enhancing energy expenditure with promotion of fat oxidation and hepatic lipolysis and suppressing hepatic lipogenesis in db/db mice. Metabolites 15(5):333, 2025. doi: 10.3390/metabo15050333. (*Corresponding author)
原口翼, 増田渉, 城内文吾, 原野雅子, 田中一成. エソ（Synodontidae）すり身は白色脂肪組織の蓄積を低減する. 日本食品科学工学会誌, 72(2):35–41, 2025. doi: 10.3136/nskkk.NSKKK-D-24-00030

2024

Wang S, Nakamura Y, Shirouchi B, Hashimoto Y, Tanaka Y, Nakao A, Goromaru R, Iwamoto M, Sato M. Quantities of vitamin D in Japanese meals using gas chromatography-mass spectrometry (GC-MS) and prediction of their sources by multiple logistic regression analysis. J Food Meas Charact. 18:8121–8134, 2024. doi: 10.1007/s11694-024-02734-0
花村衣咲, 城内文吾, 吉田恵理子, 永峯卓哉, 世羅至子. 非糖尿病若年者におけるHOMA-IRと血中脂質画分の奇数鎖および偶数鎖脂肪酸との関連. 日本栄養・食糧学会誌, 77(5):353–361, 2024.
Higuchi M, Okumura M, Mitsuta S, Shirouchi B*. Dietary cholest-4-en-3-one, a cholesterol metabolite of gut microbiota, alleviates hyperlipidemia, hepatic cholesterol accumulation, and hyperinsulinemia in obese, diabetic db/db mice. Metabolites 14(6):321, 2024. doi: 10.3390/metabo14060321. (*Corresponding author)
Omagari K, Ishida J, Murata K, Araki R, Yogo M, Shirouchi B, Suruga K, Sera N, Koba K, Ichimura-Shimizu M, Tsuneyama K. The Effect of Barley Bran Polypenol-Rich Extracts on the Development of Nonalcoholic Steatohepatitis in Sprague-Dawley Rats Fed a High-Fat and High-Cholesterol Diet. Livers 4(2):193–208, 2024. doi: 10.3390/livers4020015.

2023

Omagari K, Maruta A, Yayama N, Yoshida Y, Okamoto K, Shirouchi B, Takeuchi S, Suruga K, Koba K, Ichimura-Shimizu M, Tsuneyama K. The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis. J Nutr Sci Vitaminol. 69(5):357–369, 2023.
Shirouchi B*, Kawahara Y, Kutsuna Y, Higuchi M, Okumura M, Mitsuta S, Nagao N, Tanaka K. Oral administration of Chaetoceros gracilis—a marine microalga—alleviates hepatic lipid accumulation in rats fed a high-sucrose and cholesterol-containing diet. Metabolites 13(3):436, 2023. doi:10.3390/metabo13030436. (*Corresponding author)
Tanaka Y, Kawano M, Nakashima S, Yamaguchi C, Asahina M, Sakamoto M, Shirouchi B, Tashiro K, Imaizumi K, Sato M. Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats. Sci Rep. 13(1):3053, 2023. doi: 10.1038/s41598-022-26115-z.
Yamasaki K, Yoshikawa M, Nishihara K, Hamajima H, Oogai S, Shirouchi B, Katsuragi H, Nagata Y, Yanagita T, Koba K. Perilla pomace, a by-product of oil extraction, is rich in nutrients and can favorably modulate lipid metabolism in Sprague-Dawley rats. J Oleo Sci. 72(2):189-197, 2023. doi: 10.5650/jos.ess22336.
Shimada M, Shirouchi B, Kobayashi Y, Higuchi M, Okumura M, Nakagawa T, Hayakawa T. Treatment with interleukin-25 suppresses short-term high-fructose diet-induced hepatic gene expression and activity of fatty acid synthesis enzymes in rats. J Oleo Sci. 72(1):99-104, 2023. doi: 10.5650/jos.ess22266.

2022

花村衣咲, 城内文吾, 柴崎貢志, 大澤得二. 齧歯類の舌組織における味蕾の分布及び部位別の味細胞の増殖能―HE染色標本とPCR法および免疫組織化学的解析を用いた検討―. 長崎県立大学看護栄養学部紀要 20: 105-113, 2022.
Shirouchi B*, Fukuda A, Akasaka T. Unlike glycerophosphocholine or choline chloride, dietary phosphatidylcholine does not increase plasma trimethylamine-N-oxide levels in Sprague-Dawley rats. Metabolites 12(1):64, 2022. doi: 10.3390/metabo12010064. (*Corresponding author)

This manuscript was selected as a "Hot Topic Paper" published in 2022 in the "Food Metabolomics" section.

2021

Takeyama A, Teramoto A, Wang T, Hayashi T, Tanaka Y, Sato M, Shirouchi B*. Dietary lysophospholipids reduce lymphatic cholesterol transport compared with dietary phospholipids in thoracic lymph-duct cannulated rats. Lipids 56(6):579-590, 2021. doi: 10.1002/lipd.12319. (*Corresponding author)

This manuscript was given "The 2022 AOCS Phospholipid Division Best Paper Award".

Jiang Z, Kimura Y, Shirouchi B, Tanaka Y, Tsai WT, Yuan X, Sato M. Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression. J Nutr Biochem. 98:108820, 2021. doi: 10.1016/j.jnutbio.2021.108820.
Yuan X, Minobe Y, Tanaka Y, Fukuda Y, Furukawa Y, Miyago M, Mizokami T, Tsai WT, Jiang Z, Tong LT, Akasaka T, Shirouchi B, Toyosawa Y, Kumamaru T, Sato M. α-Globulin-rich rice cultivar, low glutelin content-1 (LGC-1), decreases serum cholesterol concentration in exogenously hypercholesterolemic rats. J Sci Food Agric. 101(15):6417-6423, 2021. doi: 10.1002/jsfa.11312.
Tsai WT, Nakamura Y, Akasaka T, Katakura Y, Tanaka Y, Shirouchi B, Jiang Z, Yuan X, Sato M. Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high-fat diet-fed mice. J Food Sci. 86(5):2103-2117, 2021. doi: 10.1111/1750-3841.15696.
大澤得二, 城内文吾. アフリカツメガエル（Xenopus laevis）発生過程における頭部骨格形成―光学顕微鏡像とX線CT画像を用いて―. 長崎県立大学看護栄養学部紀要 19: 1-10, 2021.

2020

Lee JY, Shimizu H, Hagio M, Fukiya S, Watanabe M, Tanaka Y, Joe GH, Iwasa H, Yoshitsugu R, Kikuchi K, Tsuji M, Baba N, Nose T, Tada K, Hanai T, Hori S, Takeuchi A, Furukawa Y, Shirouchi B, Sato M, Ooka T, Ogura Y, Hayashi T, Yokota A, Ishizuka S. 12α-hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats. BBA - Molecular and Cell Biology of Lipids. 1865(12):15811, 2020. doi: 10.1016/j.bbalip.2020.158811.
Jiang Z, Hayashi T, Kashima K, Kurotani K, Shirouchi B, Mizoue T, Sato M. Alteration of serum phospholipid n-6 polyunsaturated fatty acid compositions in non-alcoholic fatty liver disease in the Japanese population: A cross-sectional study. Lipids 55(6):599-614, 2020. doi: 10.1002/lipd.12251.
Hori S, Abe T, Lee DG, Fukiya S, Yokota A, Aso N, Shirouchi B, Sato M, Ishizuka S. Association between 12α-hydroxylated bile acids and hepatic steatosis in rats fed a high-fat diet. J Nutr Biochem. 83: 108412, 2020. doi: 10.1016/j.jnutbio.2020.108412.
Wanezaki S, Saito S, Inoue N, Tachibana N, Shirouchi B, Sato M, Yanagita T, Nagao K. Soy β-conglycinin peptide attenuates obesity and lipid abnormalities in obese model OLETF rats. J Oleo Sci. 69(5): 495-502, 2020.
Shirouchi B, Yanagi S, Okawa C, Koga M, Sato M. 6-Ketocholestanol suppresses lipid accumulation by decreasing FASN gene expression through SREBP-dependent regulation in HepG2 cells. Cytotechnology. 72(1): 175-187, 2020.

Kanasaki A, Iida T, Murao K, Shirouchi B, Sato M. D-Allulose enhances uptake of HDL-cholesterol into rat's primary hepatocyte via SR-B1. Cytotechnology. 72(2): 295-301, 2020.

Tanaka Y, Ono M, Miyago M, Suzuki T, Miyazaki Y, Kawano M, Asahina M, Shirouchi B, Imaizumi K, Sato M. Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats. PLoS One 15(3): e0229669, 2020.

2019

城内文吾. 食事リン脂質の脂質代謝調節作用. 日本栄養・食糧学会誌. 72(6): 247-255, 2019.

Kanasaki A, Jiang Z, Mizokami T, Shirouchi B, Iida T, Nagata Y, Sato M. Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters. J Funct Foods. 60: 103429, 2019.

Shirouchi B*, Matsuoka R. Alleviation of metabolic syndrome with dietary egg white protein. J Oleo Sci. 68(6): 517-524, 2019. (*Corresponding author)

Shimada M, Ichigo Y, Shirouchi B, Takashima S, Inagaki M, Nakagawa T, Hayakawa T. Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-β and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. Nutr Res. 64: 49-55, 2019.

Shirouchi B, Furukawa Y, Nakamura Y, Kawauchi A, Imaizumi K, Oku H, Sato M. Inhibition of Niemann-Pick C1-Like 1 by ezetimibe reduces dietary 5β,6β-epoxycholesterol absorption in rats. Cardiovasc Drugs Ther. 33(1): 35-44, 2019.

Niibo M*, Shirouchi B*, Umegatani M, Morita Y, Ogawa A, Sakai F, Kadooka Y, Sato M. Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model. J Dairy Sci. 102(2): 997-1006, 2019. (*These authors contributed equally.)

2018

Gotoh E, Suetsugu N, Yamori W, Ishishita K, Kiyabu R, Fukuda M, Higa T, Shirouchi B, Wada M. Chloroplast accumulation response enhances leaf photosynthesis and plant biomass production. Plant Physiol. 178(3): 1358-1369, 2018.

Takeyama A, Nagata Y, Shirouchi B, Nonaka C, Aoki H, Haraguchi T, Sato M, Tamaya K, Yamamoto H, Tanaka K. Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats. J Oleo Sci. 67(9): 1137-1147, 2018.

Tanaka Y, Takahashi K, Kato JI, Sawazaki A, Akasaka T, Fujita N, Kumamaru T, Saito Y, Shirouchi B, Sato M. Starch synthase IIIa and starch branching enzyme IIb-deficient mutant rice line ameliorates pancreatic insulin secretion in rats: screening and evaluating mutant rice lines with antidiabetic functionalities. Br J Nutr. 119(9): 970-980, 2018.

Shirouchi B, Yamanaka R, Tanaka S, Kawatou F, Hayashi T, Takeyama A, Nakao A, Goromaru R, Iwamoto M, Sato M. Quantities of phospholipid molecular classes in Japanese meals and prediction of their sources by multiple regression analysis. J Nutr Sci Vitaminol. 64(3): 215-221, 2018.

Nagamoto J, Sawazaki A, Miyago M, Shirouchi B, Sakata M, Tong LT, Kumamaru T, Sato M. Rapid semi-quantification of triacylglycerols, phosphatidylcholines, and free fatty acids in the rice bran of one grain. J Integr Agric. 17(5): 977-981, 2018.

2017

Matsuoka R*, Shirouchi B*, Umegatani M, Fukuda M, Muto A, Masuda Y, Kunou M, Sato M. Dietary egg-white protein increases body protein mass and reduces body fat mass through an acceleration of hepatic β-oxidation in rats. Br J Nutr. 118(6): 423-430, 2017. (*These authors contributed equally.)

Hiraki E, Furuta S, Kuwahara R, Takemoto N, Nagata T, Akasaka T, Shirouchi B, Sato M, Ohnuki K, Shimizu K. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 71(3): 482-491, 2017.

Shirouchi B, Kashima K, Horiuchi Y, Nakamura Y, Fujimoto Y, Tong LT, Sato M. 27-Hydroxycholesterol suppresses lipid accumulation by down-regulating lipogenic and adipogenic gene expression in 3T3-L1 cells. Cytotechnology 69(3): 485-492, 2017.

Kurotani K, Sato M, Yasuda K, Kashima K, Tanaka S, Hayashi T, Shirouchi B, Akter S, Kashino I, Hayabuchi H, Mizoue T. Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines. PLoS One 12(5): e0178192, 2017.

2016

Shirouchi B, Nagao K, Umegatani M, Shiraishi A, Morita Y, Kai S, Yanagita T, Ogawa A, Kadooka Y, Sato M. Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure. Br J Nutr. 116(3): 451-458, 2016.

2015

Inoue C, Kozaki T, Morita Y, Shirouchi B, Fukami K, Shimizu K, Sato M, Katakura Y. Kibizu concentrated liquid suppresses the accumulation of lipid droplets in 3T3-L1 cells. Cytotechnology 67(4): 721-725, 2015.

Yoshinaga K, Sasaki K, Watanabe H, Nagao K, Inoue N, Shirouchi B, Yanagita T, Nagai T, Mizobe H, Kojima K, Beppu F, Gotoh N. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. J Nutr Biochem. 26(1): 57-63, 2015.

2014

Matsuoka R*, Shirouchi B*, Kawamura S, Baba S, Shiratake S, Nagata K, Imaizumi K, Sato M. Dietary egg white protein inhibits lymphatic lipid transport in thoracic lymph duct-cannulated rats. J Agric Food Chem. 62(44): 10694-10700, 2014. (*These authors contributed equally.)

Ogawa A, Kadooka Y, Kato K, Shirouchi B, Sato M. Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects. Lipids Health Dis. 13: 36, 2014.

Tan H, Furuta S, Nagata T, Ohnuki K, Akasaka T, Shirouchi B, Sato M, Kondo R, Shimizu K. Inhibitory effects of the leaves of loquat (Eriobotrya japonica) on bone mineral density loss in ovariectomized mice and osteoclast differentiation. J Agric Food Chem. 62(4): 836-841, 2014.

Shirouchi B, Albrecht E, Nuernberg G, Maak S, Olavanh S, Nakamura Y, Sato M, Gotoh T, Nuernberg K. Fatty acid profiles and adipogenic gene expression of various fat depots in Japanese Black and Holstein steers. Meat Sci. 96(1): 157-164, 2014.

2013

Mizunoya W, Iwamoto Y, Shirouchi B, Sato M, Komiya Y, Razin FR, Tatsumi R, Sato Y, Nakamura M, Ikeuchi Y. Dietary fat influences the expression of contractile and metabolic genes in rat skeletal muscle. PLoS One 8(11): e80152, 2013.

Iwamoto M, Yagi K, Yazumi K, Komine A, Shirouchi B, Sato M. Eating a healthy lunch improves serum alanine aminotransferase activity. Lipids Health Dis. 12: 134, 2013.

Inoue N, Inafuku M, Shirouchi B, Nagao K, Yanagita T. Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice. Lipids Health Dis. 12: 18, 2013.

2012

Shirouchi B, Nakamura Y, Furukawa Y, Shiraishi A, Tomoyori H, Imaizumi K, Sato M. Ezetimibe inhibits lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats. Cardiovasc Drugs Ther. 26(5): 427-431, 2012.

Iwamoto M, Imai K, Ohta H, Shirouchi B, Sato M. Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women. Lipids Health Dis. 11: 52, 2012.

Inafuku M, Nagao K, Nomura S, Shirouchi B, Inoue N, Nagamori N, Nakayama H, Toda T, Yanagita T. Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db mice. Br J Nutr. 107(5): 639-646, 2012.

Tsuruta Y, Nagao K, Shirouchi B, Nomura S, Tsuge K, Koganemaru K, Yanagita T. Effects of lotus root (the edible rhizome of Nelumbo nucifera) on the development of non-alcoholic fatty liver disease in obese diabetic db/db mice. Biosci Biotechnol Biochem. 76(3): 462-466, 2012.

丸居篤, 水野谷航, 中野豊, 城内文吾, 友永省三, 清水邦義, 泉清隆, 堀江ちひろ. イノシシ肉ソーセージの理化学的特性および食味評価. 日本暖地畜産学会報 55(2): 177-180, 2012.

2011

Sato M, Ueda T, Nagata K, Shiratake S, Tomoyori H, Kawakami M, Ozaki Y, Okubo H, Shirouchi B, Imaizumi K. Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats. Exp Biol Med. 236(10): 1139-1146, 2011.

Shirouchi B, Kawamura S, Matsuoka R, Baba S, Nagata K, Shiratake S, Tomoyori H, Imaizumi K, Sato M. Dietary guar gum reduces lymph flow and diminishes lipid transport in thoracic duct-cannulated rats. Lipids 46(8): 789-793, 2011.

Inoue N, Nagao K, Nomura S, Shirouchi B, Inafuku M, Hirabaru H, Nakahara N, Nishizono S, Tanaka T, Yanagita T. Effect of Vaccinium ashei reade leaf extracts on lipid metabolism in obese OLETF rats. Biosci Biotechnol Biochem. 75(12): 2304-2308, 2011.

2010

Nagao K, Yamano N, Shirouchi B, Inoue N, Murakami S, Sasaki T, Yanagita T. Effects of citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo. J Agric Food Chem. 58(16): 9028-9032, 2010.

Nagao K, Inoue N, Inafuku M, Shirouchi B, Morooka T, Nomura S, Nagamori N, Yanagita T. Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db/db mice. J Nutr Biochem. 21(5): 418-423, 2010.

Shirouchi B, Nagao K, Furuya K, Shiojiri M, Liu X, Yanagita T. Physiological effects of dietary PIPS soybean-derived phospholipid in obese Zucker (fa/fa) rats. Biosci Biotechnol Biochem. 74(11): 2333-2335, 2010.

Shirouchi B, Nagao K, Furuya K, Nagai T, Ichioka K, Tokairin S, Iida Y, Yanagita T. Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats. J Oleo Sci. 59(6): 299-305, 2010.

2009

Gotoh N, Nagao K, Onoda S, Shirouchi B, Furuya K, Nagai T, Mizobe H, Ichioka K, Watanabe H, Yanagita T, Wada S. Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-db/db mice. J Agric Food Chem. 57(22): 11047-11054, 2009.

Shirouchi B, Nagao K, Furuya K, Inoue N, Inafuku M, Nasu M, Otsubo K, Koga S, Matsumoto H, Yanagita T. Effect of dietary phosphatidylinositol on cholesterol metabolism in Zucker (fa/fa) rats. J Oleo Sci. 58(3): 111-115, 2009.

2008

Nagao K, Higa K, Shirouchi B, Nomura S, Inoue N, Inafuku M, Yanagita T. Effect of Vaccinium ashei reade leaves on lipid metabolism in Otsuka Long-Evans Tokushima Fatty rats. Biosci Biotechnol Biochem. 72(6): 1619-1622, 2008.

Shirouchi B, Nagao K, Inoue N, Furuya K, Koga S, Matsumoto H, Yanagita T. Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. J Agric Food Chem. 56(7): 2375-2379, 2008.

Nagao K, Inoue N, Ujino Y, Higa K, Shirouchi B, Wang YM, Yanagita T. Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice. Lipids Health Dis. 7: 8, 2008.

2007

Sakaida H, Nagao K, Higa K, Shirouchi B, Inoue N, Hidaka F, Kai T, Yanagita T. Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo. Biosci Biotechnol Biochem. 71(9): 2335-2337, 2007

Shirouchi B, Nagao K, Inoue N, Ohkubo T, Hibino H, Yanagita T. Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats. J Agric Food Chem. 55(17):7170-7176, 2007.

This manuscript was given "The 2009 AOCS Phospholipid Division Best Paper Award".

2006

Inoue N, Nagao K, Wang YM, Noguchi H, Shirouchi B, Yanagita T. Dietary conjugated linoleic acid lowered tumor necrosis factor-alpha content and altered expression of genes related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker rats. J Agric Food Chem. 54(20):7935-7939, 2006.

2005

Nagao K, Inoue N, Wang YM, Shirouchi B, Yanagita T. Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. J Nutr. 135(1):9-13, 2005.

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