Streamlining Ethics and Institutional Approvals
(Week of November 3, 2025)
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Primary Content
Primary Content
Module 5-2 – Streamlining Ethics and Institutional Approvals for Multi-Site Trials (15-Minute Video)
Launching a pragmatic trial across hospitals or provinces can feel overwhelming—but it doesn’t have to be. This HDRN module walks you through how to navigate ethics and institutional approvals efficiently. Learn when a single Research Ethics Board (REB) can cover multiple sites, how pan-Canadian platforms like Can-Review streamline submissions, and what contracts and authorizations must align before launch. Whether your trial spans one hospital or several provinces, you’ll discover practical strategies to harmonize ethics, institutional, and contractual steps so your study starts smoothly and on schedule.
** The video's content and narration were generated with the assistance of artificial intelligence, with human guidance and oversight throughout the process. **
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Curriculum Wheel
Additional Material
Additional Material
Example of Workflows Using an Ontario-Centric Model
Example of Workflows Using an Ontario-Centric Model
Board-of-Record Systems for Multi-Site Clinical Research in Canada.pdftcps2-2022-.pdfTri-Council Policy Statement: Ethical Conduct for Research Involving Humans (Source)
The Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (TCPS 2, 2022) is Canada’s national framework for ensuring that all research involving human participants, data, or biological materials is conducted ethically. Jointly issued by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), and Social Sciences and Humanities Research Council (SSHRC), it establishes the principles of Respect for Persons, Concern for Welfare, and Justice as the foundation for ethical decision-making in research. The policy outlines requirements for informed consent, privacy and confidentiality, fairness and inclusion, Indigenous engagement, and Research Ethics Board (REB) oversight, while also addressing specialized contexts such as clinical trials, qualitative studies, and genetic or biological material research. Compliance with TCPS 2 is mandatory for any research funded by the Tri-Council agencies and serves as the ethical benchmark for all human research in Canada.
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