Exemplar Trial Overview - RegisterNow-1. (17-min video & 36-slide presentation)

• Summary: There is a persistent shortage of organs available for transplant worldwide, and while most people support donating their organs when they die, many have not registered to do so. Dr. Alvin Li overviews a pragmatic stepped-wedge cluster randomized controlled trial of an intervention to address barriers and enablers to organ donation registration. The intervention involved family physician office reception staff inviting their patients to register for organ donation (on a tablet in the waiting room) while they waited for their appointment.

Li AH, et al. Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1): a pragmatic stepped-wedge, cluster randomized controlled registry trial. BMC Med. 2022 Mar 3;20(1):75. (10-page paper)

• Summary: Publication in BMC Medicine describing a pragmatic trial with the primary aim of evaluating the effectiveness of an intervention to promote organ donation registration in family physician’s offices. All offices began with usual care and then every two weeks, one office (randomly assigned) started the intervention until all offices delivered the intervention. The primary outcome was registration for deceased organ donation in the provincial organ donation registry (assessed within the 7 days of the physician visit). At the end of the trial, interviews with clinic staff were completed to assess barriers and enablers to delivering the intervention.

Exemplar Trial - RegisterNow-1. (8-min video & 16-slide presentation)

• Summary: Dr. Alvin Li breaks down the pragmatic stepped-wedge cluster randomized controlled trial across sections of the curriculum wheel.

Li AH, et al. Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry. Trials. 2017 Dec 21;18(1):610. (13-page paper)

• Summary: This protocol describes a stepped-wedge cluster randomized controlled trial in six family physician offices in Ontario, Canada to evaluate the effectiveness of reception staff providing patients with a pamphlet that addresses barriers/enablers to organ donation registration (including a description of how to register for organ donation).

Garg AX, et al. Promoting Organ Donor Registration in Family Physician Offices. ClinicalTrials.gov identifier: NCT03213171. Updated 2024-03-05. (8-section website)

• Summary: Public registration of the trial (i.e., study overview, contacts and locations, study plan, collaborators and investigators, publications, study record dates).