Exemplar Trials

To supplement educational content from sections of the curriculum wheel, leading trialists will overview their experience in the design, implementation, and management of a published pragmatic trial.

Exemplar trial modules include a general overview of the pragmatic trial (backgrounds, methods, results, discussion) and a discussion of the trial using sections of the curriculum wheel.

To date, published pragmatic trials overviewed in the exemplar trial modules include:

Week of July 22, 2024: Effect of a multicomponent intervention to improve patient access to kidney transplant and living kidney donation: a pragmatic, cluster-randomized trial (EnAKT LKD)
Week of August 26, 2024: Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial (AToM)
Week of October 7, 2024: Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial (ISLAND)
Week of November 18, 2024: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial (MyTEMP)
Week of December 16, 2024: Mailed feedback to primary care physicians on antibiotic prescribing for patients aged 65 years and older: pragmatic, factorial randomised controlled trial (Schwartz, et al.)
Week of January 27, 2025: Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1): a pragmatic stepped-wedge, cluster randomized controlled registry trial (RegisterNow-1)
Week of February 24, 2025: Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial (AcT)
Week of March 24, 2025: Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial (Contrast RISK)
Week of April 21, 2025: Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial (STRATUS)
Week of May 19, 2025: Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial (Be-Free)

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