Pragmatic Trials and Reconciliation
(Week of November 17, 2025)
(Week of November 17, 2025)
Module 5-3 – Pragmatic Trials and Reconciliation: Advancing Indigenous Health Through Respectful Research (20-Minute Video)
This module explores how pragmatic trials can contribute to reconciliation and help close health gaps between Indigenous and non-Indigenous communities in Canada. The module introduces key principles such as micro-reconciliation, ethical space, and Indigenous data sovereignty (OCAP and CARE). Drawing on the Truth and Reconciliation Commission’s Call to Action 19, the session emphasizes collaboration, co-governance, and respect for Indigenous knowledge systems. Learners will discover how designing trials “with” rather than “on” communities—valuing both Indigenous and Western approaches—can transform research into a tool for equity, trust, and lasting change in health outcomes.
** The video's content and narration were generated with the assistance of artificial intelligence, with human guidance and oversight throughout the process. **
Summary: The Truth and Reconciliation Commission of Canada’s 2015 Calls to Action outlines 94 measures aimed at addressing the ongoing impacts of the residential school system and advancing reconciliation between Indigenous and non-Indigenous peoples. The document urges all levels of government, institutions, and Canadians to take concrete action in areas such as child welfare, education, health, justice, and language revitalization, while also promoting cultural understanding, legal reform, and equitable treatment of Indigenous peoples. It calls for the full implementation of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), the creation of a National Council for Reconciliation, and greater inclusion of Indigenous voices in education, media, business, and governance. Overall, it frames reconciliation as an ongoing, collective responsibility that requires truth, respect, and systemic change across every aspect of Canadian society.
Summary: In this paper, the authors argue that improving diversity in clinical trials is essential to building trust, promoting fairness, and advancing biomedical knowledge. They note that historically marginalized groups remain underrepresented in research, which fuels medical mistrust and inequities in care. The paper emphasizes rebuilding trust through inclusive and transparent study practices, advancing fairness by removing barriers to participation and ensuring equitable distribution of benefits, and acknowledging that while diversity can enhance scientific validity, its primary value lies in justice and ethical responsibility. Ultimately, it concludes that fostering inclusiveness in trials strengthens both the credibility of medicine and the fairness of the research system itself.
Summary: In this paper, Willie Ermine introduces the concept of “ethical space” as a framework for respectful engagement between Indigenous and Western worldviews. He argues that this conceptual space is created when two distinct societies, each with its own history, philosophy, and values, come together to interact on equal terms. The paper critiques the ongoing dominance of Western thought, which has historically marginalized Indigenous knowledge systems, and calls for new rules of engagement grounded in ethics, respect, and mutual recognition. Ermine emphasizes that reconciliation requires acknowledging cultural diversity, dismantling assumptions of Western universality, and fostering genuine dialogue that values both perspectives. The ethical space, he proposes, can serve as a neutral meeting ground where dialogue replaces dominance, enabling a new partnership model between Indigenous peoples and Western institutions built on cooperation, justice, and shared humanity.