Statistical rigor is essential to producing precise and valid evidence that can inform healthcare policies, guide clinical decision making, and improve patient outcomes across a broad spectrum of real-world conditions. This section will overview statistical considerations and related methodologies that may emerge when handling complexities introduced in pragmatic trials.
Modules from this section, featured in previous weeks, will be posted here over time.
Week of October 28, 2024: Confounding and randomization: an introduction
Week of April 7, 2025: Estimands in clinical trials
Week of April 14, 2025: Statistical analysis plans for clinical trials
Week of May 12, 2025: Statistical analysis in trials: an introduction
Week of June 2, 2025: P-values, confidence intervals, and multiple testing
Week of June 16, 2025: Covariate adjustment in randomized trials