Unit-I: Basics of Immunology (15 HOURS)

i. Introduction to the Immune System (Innate and Adaptive Immunity)

ii. Antigens and Antibodies – Structure and Properties

iii. Cells and Organs of the Immune System (Primary & Secondary Lymphoid Organs)

iv. Introduction to Immunogenetics – Genetic Control of Immune Function

Unit-II: Genetics of Immunoglobulins and Antibody Diversity (15 HOURS)

i. Immunoglobulin Structure, Classes (IgG, IgA, etc.) and Biological Functions

ii. Genetic Organization of Immunoglobulin Genes (Heavy and Light Chains)

iii. V(D)J Recombination and Generation of Antibody Diversity

 iv. Somatic Hypermutation and Class Switch Recombination

Unit-III: Immunogenetics in Health and Disease 15 HOURS)

 i. Genetic Regulation of Cytokines and Receptors (e.g., TNF-α and TNF-R)

ii. TNF-α Polymorphism and Genetic Susceptibility to Autoimmune Diseases

 iii. Epigenetic Modifications in Immune Regulation (e.g., DNA methylation, histone changes)

  iv. Immunogenetics of Infectious Diseases (e.g., HIV)

UNIT IV: PRACTICALS (1CREDITS: 30 HOURS)

      i.         Demonstration of Lymphoid Organs

     ii.         Histological Study Primary and Secondary Lymphoid Organs Through Silde or Photographs

   iii.         Blood Grouping (ABO and Rh Typing)

    iv.         Preparation of Blood Smear and Identification of Immune Cells

     v.         Demonstration of ElISA and Immunoelectrophoresis

Books recommended:

      i.         Kuby Immunology : Punt, Stranford, Jones, Owen

     ii.         Cellular and Molecular Immunology: Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai

   iii.         Paul's Fundamental Immunology: Edited by William E. Paul