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Semester 2nd

(Human Genetics-NEP)

Department of Human Genetics, Sri Pratap College, Srinagar

Essentials of Genetics

Welcome to Semester 2 entitled "Essentials of Genetics". This semester, we will build upon the foundational concepts introduced in Semester 1 by delving deeper into the principles of genetics. Our focus will be on understanding Mendelian and non-Mendelian inheritance, gene mapping, and chromosomal abnormalities. We will explore classical inheritance patterns, examine the intricacies of gene mapping, and study various chromosomal abnormalities and their associated syndromes.

These topics are crucial for a thorough understanding of genetic principles and their real-world applications. By the end of this semester, you will have a robust understanding of genetic inheritance and be able to interpret complex genetic data, preparing you for advanced studies and research in the field of genetics.

Unit-wise Learning Modules

This course consists of three theory units and one practical unit (Course Credit: 3+1). You may access the complete course details through the link provided below.

Classical Genetics

Unit I

Gene Mapping

Unit II

Chromosomal Abnormalities

Unit III

Unit 4

Laboratory Component

Practical laboratory exercises to reinforce theoretical concepts

1: Numericals Based on Mendelian Inheritance: Solve genetic problems involving dominant, recessive, and co-dominant traits using Mendel's laws

2: Numerical Problems on Gene Interactions: Calculate ratios for complementary, inhibitory, duplicate and supplementary gene interactions

3: Study of Human Morphogenetic Traits: Observe and analyze physical characteristics and their genetic basis in human populations

4: Study of Abnormal Human Karyotypes: Examine chromosomal abnormalities and genetic disorders through karyotype analysis

5: Survey of Local Area for Different Genetic Traits: Conduct field surveys to document genetic variation and inheritance patterns in local populations

Enter into the Lab Course

Semester 2-NEP Syllabus

UNIT 1: Mendelian and Non-Mendelian Inheritance

1.1 Monohybrid, Dihybrid, trihybrid crosses. Law of segregation, Law of independent assortment.

1.2 Incomplete dominance, co-dominance, epistasis.

1.3 Pleiotropism, multiple alleles, lethal gene, sex-linked, sex-limited, sex-influenced inheritance.

1.4 Quantitative inheritance, extra nuclear inheritance.

UNIT 2: Gene Mapping

2.1 Linkage.

2.2 Crossing over.

2.3 Linkage maps.

2.4 Haploid Mapping (Tetrad analysis in yeast and Neurospora).

UNIT 3: Chromosomal Abnormalities

3.1 Variation in chromosome structure and their meiotic consequences.

3.2 Structural chromosome abnormalities: Cri du chat syndrome, Chronic myelogenous leukemia, Wolf Hirschhorn syndrome.

3.3 Autosomal chromosome abnormalities: Euploidy/Aneuploidy, Down syndrome, Edward syndrome, Patau syndrome.

3.4 Sex chromosome abnormalities: Klinefelter syndrome, Turner syndrome, super male, super female.

UNIT 4: Lab Course

1. Numericals based on Mendelian inheritance.

2. Numerical problems based on gene interactions (Complementary, Inhibitory, Duplicate and Supplementary).

3. Study of human morphogenetic traits.

4. Study of abnormal human karyotypes.

5. Survey of local area for different genetic traits