Framing of coding dictionary
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Framing of coding dictionary
The genetic code is the set of rules by which nucleotide sequences in mRNA are translated into amino acids to form proteins. It is a triplet, universal, non-overlapping, and degenerate code that assigns specific amino acids to codons (three-nucleotide sequences). The code includes start codons (AUG) for initiation and stop codons (UAA, UAG, UGA) for termination of protein synthesis.
The genetic code has the following key characteristics:
Triplet Nature → Each codon consists of three nucleotides (e.g., AUG, UUU, GGA).
Universality → The genetic code is nearly universal, meaning that most organisms use the same codons for the same amino acids. (Exceptions exist in mitochondria and some microorganisms.)
Degeneracy (Redundancy) → Multiple codons can code for the same amino acid. For example, Leucine (Leu) is encoded by UUA, UUG, CUU, CUC, CUA, and CUG.
Non-Overlapping → Codons are read one after another, without overlap (e.g., AUGUUUCAA is read as AUG - UUU - CAA, not AUG - GUU - UCA).
Commaless → There are no breaks between codons; the sequence is read continuously from the start codon.
Unambiguous → Each codon codes for only one specific amino acid (e.g., UUU always codes for Phenylalanine).
Start and Stop Codons: AUG (Methionine) acts as the start codon for translation. UAA, UAG, and UGA are stop codons that signal termination of protein synthesis.
Wobble Hypothesis → The third nucleotide of a codon is flexible (wobbles), allowing one tRNA to recognize multiple codons (e.g., GGU, GGC, GGA, and GGG all code for Glycine).