Protein to Disease
Introduction
For this project we were given a task, with a group of three, which is shown below to pick a disease, research it, and compare the normal protein to the disease protein. We found the disease protein and the amino acid sequence and used our knowledge of proteins and protein synthesis to elaborate more on this topic. We created a slideshow presentation to demonstrate our understanding.
What is hemochromatosis?
Primary or hereditary hemochromatosis is a disorder where too much iron builds up in your body. Sometimes it's called “iron overload.” Normally, your intestines absorb just the right amount of iron from the foods you eat. But in hemochromatosis, your body absorbs too much, and it has no way to get rid of it.
Content
Transcription
Transcription takes place in the nucleus. mRNA acts as a messenger and brings the code for the ribosome to translate into a polypeptide chain (protein). Ribosomes (made up of RNA and protein) translates mRNA and creates the polypeptide chain. Large Ribosomal Subunit-sits on top of the mRNA strand and joins amino acids to form a polypeptide chain. Our DNA code is AAT-AGC-TGT-AGG-GTG-ACT-TCT-GG and our mRNA code is UUA-UCG-ACA-UCC-CAC-UGA-AGA-CC.
Translation
Translation is the process by which a protein is synthesized from the information contained in a molecule of messenger RNA (mRNA). Translation occurs in the ribosomes and cytoplasm.Codon transcription translation DNA mRNA anticodon ribosome tRNA nucleotide amino acid.
Protein Folding
First the protein is formed from its twenty amino acids as a polypeptide chain in its primary structure. Then it begins to fold in localized areas which is called its secondary structure. The tertiary structure of a protein refers to its now three dimensional shape. Quaternary structure is when subunits of a larger protein come together. This occurs so the protein can function properly.
Conclusion:
In this assignment I felt that I communicated and collaborated well with my group. We worked well together. We split up the workload evenly and discussed our findings. Everyone put in equal effort. In future projects I plan to work harder on creativity. I could try to branch away from the exact guidelines of the project and think outside the box a bit. I would also like to work on applying cultural competence to my assignments. It is often challenging for me to find a way to apply this ¨C¨ to my science projects.
Overall I found this project very interesting and engaging. I enjoyed being able to research and learn about how diseases work in the human body.