Welcome to Region IV

The 2025 Region IV High School Science & Engineering Fair took place on Friday, March 7, 2025 at Tufts University.

Congratulations to all our award winners! Click here to see all prize winners and to see a list of students who will advance to MSEF.

Congratulations to Ethan Yan, our 2025 Sanofi Specialty Care Grand Prize Winner and ISEF Representative for Region IV!

Ethan Yan, Groton School, "Empowering Low-Resource Settings with RetinAI: An AI System with Wearable Headset and Retinal Imaging for Eye Tumor Home-Screening"

Congratulations to our 2025 First Place Winners! Listed in alphabetical order by first name.

Anika Jacob, Littleton High School

"The Effects of Environmental Concentrations of Caffeine on the Neurobehavioral and Neurobiological development of Zebrafish Embryos"

Iris Yu, Lexington High School

"Inequality in the Age of AI: An Agent-Based, Machine Learning Approach to Explore AI and Economic Inequity"

Xuhong Ding, The Governor's Academy

"Artificial Intelligence-based Optical Treatment of Vitiligo"

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The six Regional Science Fairs serve as qualifying competitions for the Regeneron International Science & Engineering Fair (ISEF) and the Massachusetts Science & Engineering Fair (MSEF). At the Region IV Competition, the top project is nominated for ISEF, and the top 40 projects advance to MSEF where the awards total over $500,000.

To learn how to enter the Region IV Fair, visit our HOW TO ENTER section.

The How-To RESOURCES section will help you through your science fair experience including presentations from MSEF and videos from the Archimedes Initiative.