Congratulations to all the participants in the 2016 Region IV Science Fair. The top 43 participants win prizes, and move on to the State Science and Engineering Fair at MIT in May, and the top 3 projects moving on to the Intel International Science and Engineering Fair in Phoenix, Arizona. The 2016 Winners and top scoring projects are listed below. This year's First place winner was Vivek Bhupatiraju from Lexington High School with his project entitled Tracing Evolutionary Patterns in Western Africa: A Phylogenetic Analysis of the HIV-1 and HIV-2 Strains. Second Place was awarded to Ann Le from Medford High School with her project: Viability of co-cultured Mycobacterium smegmatis and THP-1 cell derived macrophages following infections in-vitro. Rounding out the students moving on to the International Fair was 3rd Place winner Linnea Warburton from Lexington High School and her project Mapping the Spread of Invasive Plants by UAV.