• Class:  

• Action: inhibits multiple plasminogen binding sites, decreases plasmin formation and fibrinolysis.

• Indications: Adult trauma with suspected hemorrhage. intra-thoracic, intra abdominal, pelvic or long bone fractures, SBP < 90mmHg OR heart rate > 100 or both. time of injury < 3 hours.

• Adverse Effects: allergy to TXA, thromboembolism, cerebral edema, cerebral infarction, seizures.  

• Contraindications: known allergy to TXA, head trauma, known (PE, DVT, or MI) DO NOT administer via IM

• Special Considerations: Pregnancy Class C 

Dosages:

Adults: 

1000mg (1gram) slow IVP over 1 Minute (March 2025)  

• IV AND Intraosseous IO (August 2024)

Pediatrics:

Contraindicated

COG's 

COG's - Traumatic Shock (google.com) 

Hemorrhage COG