• Class: Antiarrhythmic Class 1B

• Action: Blocks sodium channels, increasing the recovery period after repolarization; suppresses automaticity in the His-Purkinje system and depolarization in the ventricles.

• Indications: Ventricular arrhythmias, Cardiac arrest from V-Fib, V-tach, and Torsades de Pointes

• Adverse Effects: Toxicity, seizures, cardiac arrhythmias, hypotension, cardiac arrest

• Contraindications: AV Blocks, DO NOT USE, Adams-Stokes syndrome, Wolff-Parkinson-White syndrome (delta wave)

• Special Considerations: Pregnancy Class B

Dosages:

Adults:

Cardiac arrest V-fib/V-tach = 1-1.5mg/kg to a MAX of 3mg/kg

Second dose at 0.5-0.75mg/kg

Perfusing VT 0.5-0.75mg/kg IV

Pediatrics:

1mg/kg to MAX dose of 100mg