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Viruses are the smallest of all the microbes, typically between 20-300 nm in size. Viruses can only been seen using electron microscopy. They are also very different to the bacteria and fungi that we have already seen and come in many shapes (see the images below). It is disputed whether viruses are living organisms (alive) at all. This is why we say ‘types’ or ‘variants’ of virus and not ‘species’. Viruses are not made of cells and the structure of virus particles are very simple. Outside the host cell the virus particle is often called a virion.
Viruses are not cells. Simply put, they are made up of a capsid (protein coat) which contains genetic material (either DNA or RNA). Some viruses also have an envelope on the outside of the capsid. The envelope is many of proteins and lipids and these often have 'spike' proteins on them. 'Spike' proteins are often made up from the plasma (cell) membranes of the host cells.
Every living organism follows the eight characteristics of living organisms, which includes the 7 life processes - movement, respiration, sensitivity, growth, reproduction, excretion & nutrition). Viruses do not have these life processes and they are not made of cells. Viruses really only replicate inside host cells. Therefore, there is debate about whether they should be classified as living things.
Viruses are all pathogenic since they cause infectious diseases. They are also parasitic, because they always harm their host cells and are not beneficial at all to their host cells.
There are many infectious diseases in humans that are caused by viruses. Some of them are listed below:
COVID-19
Chickenpox & shingles
Rubella
Measles
Mumps
Colds
Flu (Influenza)
Polio (poliomyelitis)
HPV (Human Papilloma Virus)
HIV (Human Immunodeficiency Virus)
SARS (South Asian Respiratory Syndrome)
MERS (Middle Eastern Respiration Fever)
Viral meningitis
Cold sores
Herpes (herpes simplex)
Ebola
Zika
Hepatitis
Smallpox
Rabies
Dengue fever
Yellow fever
Viruses can only be cultured inside living cells. Fertilised hens' eggs are a suitable culture medium. Unlike bacteria and fungi, viruses cannot be cultured on an agar plate.
Viruses replicate (reproduce) by invading living host cells and using the contents of the host cell to replicate their genetic material and make new protein coats. These new virus particles are then released to infect other host cells.
Entry - the host cell plasma membrane moves around the flu virus.
Uncoating & synthesis- the protein capsid of the virus gets broken down by host cell enzymes and genetic information is released into the cytoplasm. Viral genetic material is then made by the host cell.
Synthesis - Viral protein capsids are made by the host cell.
Assembly - Capsids and genetic material are assembled into new viruses
Release - The host plasma membrane ruptures and the new viruses are released from the cell. The host cell is destroyed in the process.
Attachment - The bacteriophage virus attaches to the bacterial host cell,
Entry - The bacteriophage viral genetic material is injected into the bacterium by the bacteriophage.
Synthesis - The host bacterium chromosome is switched off and even destroyed. Then the host cell makes new viral genetic material and new viral protein coats.
Assembly - The new protein coats enclose the new viral genetic material and new bacteriophages are formed.
Release - The bacterial membrane ruptures and the new bacteriophages are released. The host cell is destroyed in the process.