P-37

Within the projects ONS BIO (RAAK MKB) and TFF Biovolt (Tech for Future), a biosensor platform based on Micro-ring resonators (MRR’s) is developed for simple, fast, low-cost and sensitive detection of various biomarkers.

The sensor used will be based on MRR technology, which requires fabrication of complex photonic structures.

To allow optimum data acquisition, specifications on refractive index changes were translated to expected resonance frequency shifts resulting in electronic design requirements. Then a survey was made of commercially available solutions. An electronic board was designed and tested.

The software task was to determine the optimum data processing rules for sensor systems based on resonant optical cavities, in particular MRR structures. More specifically optimization of a peak finding algorithm. This software is Python based to improve user enhancement for example integration of assay protocol or calculation of sample concentration based on calibration curves.

To test the integration of the optics, the electronics and the software a MRR based sensor has been developed in order to measure ketone concentration on skin to monitor the metabolic status of human cells allowing e.g. non-invasive and continuous control of the glucose levels of diabetes patients. The obtained information can be of great use for athletes (e.g. training schedules) as well.

Using multiple rings, different coatings and sensitive electronics and intelligent data processing we have been able to distinguish the presence of this ketone amongst a number of different skin related gasses.