1H → 2O → 3P → 4E
1H → 2O → 3P → 4E
HOPE Lab (Laboratory for Health, Omics and Pathway Exploration) is a research laboratory in the Department of Biochemistry and Molecular Biology at the University of Chittagong. We integrate biochemistry, microbiology, ecology, and multi-omics approaches, including genomics, glycomics, and metabolomics supported by bioinformatics, to investigate microorganisms, functional biomolecules, and biological pathways across human, animal, plant, and environmental systems. Our research spans One Health, probiotics and fermented foods, bioactive molecules, host–microbe interactions, and environmental biotechnology, connecting fundamental biological discoveries with potential applications in health, food safety, agriculture, and environmental sustainability.
We pursue a discovery-to-impact pipeline guided by the 1H → 2O → 3P → 4E framework, linking One Health challenges to the molecular mechanisms and ecological dynamics that shape biological function
1H | One Health
Human, animal, plant, and environmental health are interconnected. We study biological factors across these systems, including beneficial organisms, microbiomes, pathogens, antimicrobial resistance, and host responses, to better understand health-related processes and their wider implications.
2O | Organisms · Omics
We investigate diverse biological systems, including organisms associated with fermented foods, plants, and aquatic animals, as well as those adapted to challenging environments. Genomics, glycomics, metabolomics, and microbiome analysis help us examine their genetic, molecular, and functional characteristics.
3P | Pathways · Probiotics · Protection
We study biochemical pathways and functionally important compounds, including microbial exopolysaccharides, pigments, biosurfactants, antimicrobial compounds, and enzymes. We evaluate their biological activities and potential relevance to food preservation, health-protection, agricultural sustainability, biotechnology, and environmental management.
4E | Ecology · Environment · Evolution · Emergence
Biological systems are shaped by their environments, interactions, and adaptation over time. We study biological diversity and function across fermented foods, host-associated systems, plant habitats, alkaline settings, and polluted environments. These investigations help us understand how biological traits respond to different conditions and identify questions for further research in biotechnology, agriculture, and environmental management.
Motivated by the need to better understand the links between health, food, organisms, and the environment, HOPE Lab integrates microbial biochemistry, microbiology, ecology, and omics sciences to study organisms, metabolites, and molecular pathways relevant to human, animal, plant, and ecosystem health. The lab is guided by three core questions:
1. Which organisms, metabolites, and pathways support health and well-being?
2. Which organisms and biological compounds pose risks to health and the environment?
3. How can beneficial organisms, metabolites, and biological pathways be harnessed to improve food safety, plant health, and environmental sustainability?
Through biochemical, molecular, and genetic approaches, HOPE Lab investigates functional biomolecules, metabolic pathways, host–environment interactions, glycomics, glycoprotein expression, and microbial systems. This research aims to connect fundamental biological insights with practical solutions in health, biotechnology, food systems, and environmental sustainability.
Explore our research projects to discover how these questions are investigated through the 1H-2O-3P-4E pipeline that guides our research.
Multifunctional lactic acid bacteria from sugarcane juice with probiotic properties for gut adaptation, health benefits, food preservation and quality enhancement
Published in Scientific Reports (Nature Portfolio) ... more
Published in Analytical Science Advances (Wiley) ... more
Published in Archives of Microbiology (Springer) ... more
Bioactive exopolysaccharide from Limosilactobacillus fermentum LAB-1: Antioxidant, anti-inflammatory, antibacterial and antibiofilm properties
Published in Bioactive Carbohydrates and Dietary Fibre (Elsevier) ... more
View all peer-reviewed publications
Anthropogenic Alkaline Niches as a Habitat for Alkalitolerant Bacteria: Taxonomy, Ecophysiology, and Biotechnologically Relevant Hydrolases ... more
From “GRAS to Grass”: Lactic Acid Bacteria as One Health Probiotics for Plant Growth, Bioremediation, Soil Quality, Food Safety, and Public Health ... more
Genome analysis of Pantoea dispersa PGPR-24 reveals key genetic pathways for plant growth promotion, root colonization and nutrient mobilization ... more
Bioactive Molecules | One Health Probiotics | Functional Foods | Ecology & Extremophiles | One Health in AMR | Multi‑Omics
Research Projects | Publications | Preprints | Research Highlights | Lab Members | Prospective Students | Lab Protocols | Contact
We welcome discussions, collaborations, and scientific inquiries. Whether you are a student, researcher, or industry partner, we would be pleased to connect and explore opportunities to advance one health and sustainable biotechnology together.