An immortal man, and Fuuko, a girl whose ability, "Unluck," brings misfortune to anyone who touches her. Together, they navigate a world where various individuals possess unique abilities known as "Negators." Their goal is to uncover the truth behind their powers and the mysterious organization pursuing them. The series blends action, comedy, and supernatural elements, exploring themes of friendship, fate, and the consequences of one's abilities as Andy and Fuuko confront various challenges and adversaries along the way.