Initially, the home location of the laser cutter is located at the upper left corner. This matches up to the artboard (canvas) in your file that contains your artwork. If your artwork is 1" to the right and 1" down from the upper left corner of your file, then the laser cutter will cut / engrave your artwork 1" to the right and 1" down from the home location. This location can be moved so that you can set the home location to a new spot. Usually this is done when you want to use a scrap piece of material and want to set the new home location to where the available material is.
Setting New Home Location