Autophagy Research
Cancer cell doubling time
colon cancer cell line SW480, 5.4 days; MDA-MB-231 breast cancer cell line, 1.2 days. (Cell Death and Disease (2012) 3, e411; doi:10.1038/cddis.2012.148)
Use CreER system paper (1) Park D et al., Cell Stem Cell, 2012, 10, 259-272, March 2, 2012.
Firsts in Autophagy
First research paper about autophagy flux: Isei Tanida, Naoko Minematsu-Ikeguchi, Takashi Ueno and Eiki Kominami. Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy. Autophagy 1:2, 84-91; July/August/September 2005];
First review paper emphasizing importance of autophagy flux: Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy. 2007;3:542–545. (also see review paper:Methods in Mammalian Autophagy Research. Cell. 2010 February 5; 140(3):313–326.)