TSSC4 inhibits Autophagy-induced cell death (AuICD) in cancer cells

Chen Y and Gibson SB. Tumor Suppressing Subtransferable Candidate 4 Expression Prevents Autophagy-Induced Cell Death Following Temozolomide Treatment in Glioblastoma Cells. Front. Cell Dev. Biol., 02 March 2022. Sec. Cell Death and Survival. https://doi.org/10.3389/fcell.2022.823251 

A paradox in cancer biology: cancer cells upregulate a novel tumor suppressor TSSC4.  Find out why by reading this recent publication: Chen Y et al. Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth. Autophagy 2022, 18(6): 1274-1296.  https://doi.org/10.1080/15548627.2021.1973338.

Regulators of autophagy control a balance to determine whether cancer cells die or live.

Chen Y and Gibson SB. Three dimensions of autophagy in regulating tumor growth: cell survival/death, cell proliferation, and tumor dormancy. BBA - Molecular Basis of Disease. 2021, 1867(12): 166265. 

Chen Y et al. Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia.  Autophagy 2016, 12(6): 1029-1046.

Unanswered questions in autophagy. Chen Y and Klionsky DJ. JCS. 2011, 124(2): 161-170.

The type of ROS (reactive oxygen species) matters.

And extracellular hydrogen peroxide (H2O2) executes its functions via superoxide in the cell.

Chen Y et al. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death & Differentiation 2009, 16(7): 1040-1052. This article was collected in "CDD 25th anniversary collection: seminal papers from the past 25 years (2018) (out of 15 original articles)."

"Y Chen, et al. CELL DEATH DIFFERENTIATION, 15 (1): 171-182 JAN 2008." was selected by "2009 ScienceWatch" and collected in "CDD 25th anniversary collection: seminal papers from the past 25 years (2018) (out of 15 original articles)."