Publication
2023
KH Chuang, Z Li, HH Huang, S Khorasani Gerdekoohi, D Athwal. “Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy.” PNAS, 120(5): e2202435120. [Link]
J Grandjean,… KH Chuang,… “A consensus protocol for functional connectivity analysis in the rat brain.” Nat Neurosci, 26(4):673-681, 2023. [Link]
N Xu, L Zhang, S Larson, Z Li, WJ Pan, KH Chuang, S Keilholz. “Rodent Whole-Brain fMRI Data Processing Toolbox.” Available at: https://github.com/GT-EmoryMINDlab/rodent-whole-brain-preprocessing-recipe. Aperture Neuro. [Link]
LT Strike, NK Hansell, KH Chuang, JL Miller, GI de Zubicaray, PM Thompson, KL McMahon, MJ Wright. “The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development.” Sci Data. 10:195, 2023. [Link]
Z Li, D Athwal, HL Lee, P Sah, P Opazo, KH Chuang. “Locating causal hub of memory consolidation from spontaneous brain network in male mouse.” Nat Commun. 14:5399, 2023. [Link]
2022
XA Zhou, G Ngiam, L Qian, K Sankorrakul, EJ Coulson, KH Chuang. “The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s Disease mouse model.“ Neurobiology of Aging 117:24-32, 2022. [Link]
KH Chuang, PH Wu, Z Li, KH Fan, JC Weng. "Deep Learning Network for Integrated Coil Inhomogeneity Correction and Brain Extraction of Mixed MRI Data." Sci Rep 12: 8578, 2022. [Link].
J Grandjean, et al. “StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain.” bioRxiv [Link]
Z Li, D Athwal, HL Lee, P Sah, P Opazo, KH Chuang. “Resting-state network hubs are causally required in memory consolidation.” bioRxiv. [Link]
KH Chuang, HH Huang, S Khorasani Gerdekoohi, Z Li, D Athwal. “Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy.” bioRxiv [Link]
2021
WY Ho, I Agrawal, SH Tyan, E Sanford, WT Chang, K Lim, J Ong, BSY Tan, AAK Moe, R Yu, P Wong, G Tucker-Kellogg, E Koo, KH Chuang, SC Ling. “Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits.” Acta Neuropathologica Comm. 9:9, 2021. [Link]
HJ Cheng, KK Ng, X Qian,F Ji, Z Lu, WP Teo, P Wei, X Hong, F Nasrallah, KK Ang, KH Chuang, G Cuntai, H Yu, E Chew, J Zhou. “Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke: A pilot study.” Sci Rep. 11:8442, 2021. [Link]
Chuang KH, Meier M, Fernández-Seara MA, Kober F, Ku MC. “Renal Blood Flow Using Arterial Spin Labeling (ASL) MRI: Experimental Protocol and Principles.” Methods Mol Biol. 2216:443-453, 2021. [Free]
Chuang KH, Kober F, Ku MC. “Quantitative Analysis of Renal Perfusion by Arterial Spin Labeling.” Methods Mol Biol. 2216:655-666, 2021. [Free]
M Hu, HJ Cheng, F Ji, JSX Chong, Z Lu, W Huang, KK Ang, KS Phua, KH Chuang, X Jiang, C Guan, E Chew, J Zhou. “Brain functional changes in stroke following rehabilitation using brain-computer interface-assisted motor imagery with and without tDCS: a pilot study.” Front Hum Neurosci 15:692304, 2021. [Link]
T Ewais, J Begun, M Kenny, K Hay, E Houldin, KH Chuang, M Tefay, S Kisely. “Mindfulness based cognitive therapy for youth with inflammatory bowel disease and depression - Findings from a pilot randomised controlled trial.” J Psychosom Res:110594, 2021. [Link]
X Zhou, D Blackmore, F Nasrallah, X To, N Kurniawan, A Carlisle, KY Vien, KH Chuang, T Jiang, P Bartlett. “Neurogenic-dependent changes in hippocampal circuitry underlie the pro-cognitive effect of exercise in ageing mice.” iScience, 24: 103450, 2021. [Link]
N Xu, L Zhang, S Larson, Z Li, WJ Pan, KH Chuang, S Keilholz. Rodent Whole-Brain fMRI Data Processing Toolbox. (2021). Available at: https://github.com/GT-EmoryMINDlab/rodent-whole-brain-preprocessing-recipe .
2020
HL Lee, X Zhou, Z Li, KH Chuang. “Optimizing Diffusion MRI Acquisition Efficiency of Rodent Brain Using Simultaneous Multislice EPI.” NMR Biomed DOI: 10.1002/nbm.4398 [Link]
2019
KH Chuang, HL Lee, Z Li, WT Chang, FA Nasrallah, LY Yeow, KK D/O R Singh. “Evaluation of Nuisance Removal for Functional MRI of Rodent Brain.” NeuroImage, 188:694–709, 2019. [Link].
M Sobczak-Edmans, YC Lo, YC Hsu, YJ Chen, F Kwok, KH Chuang, WYI Tseng, SHA Chen. “Cerebro-Cerebellar Pathways for Verbal Working Memory.” Frontiers Human Neurosci., 12:530, 2019 [Link]
T Ewais, J Begun, M Kenny, KH Chuang, J Barclay, S Kisely. “Protocol for a pilot randomised controlled trial of mindfulness based cognitive therapy in youth with inflammatory bowel disease and depression.” BMJ Open, 9(4):e025568. [Link]
HL Lee, Z Li, EJ Coulson, KH Chuang. “Ultrafast fMRI of the Mouse Brain Using Simultaneous Multi-Slice EPI." NeuroImage, DOI:10.1016/j.neuroimage.2019.03.045. [Link] [preprint]
2018
Y Lv, P Chandrasekharan, Y Li, XL Liu, J Penaranda-Avila, Y Yang, KH Chuang, XJ Liang, J Ding. “Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast.” J Mater Chem B, 6:1470-1478, 2018 [Link]
ZH Toh, TAC Seah, QL Gu, WH Wong, JA McNab, KH Chuang, X Hong, PH Tang. “Increased white matter connectivity seen in young judo athletes with Magnetic Resonance Imaging.” Clinical Radiology, 73:911.e17-e21, 2018 [Link].
WT Chang, F Puspitasari, XV To, X Hong, LY Yeow, HC Tay, M Garcia-Miralles, KB Koh, LJ Tan, MA Pouladi, KH Chuang. "Connectomic imaging reveals Huntington-related pathological and pharmaceutical effects in a mouse model." NMR Biomed, 31:e4007, 2018 [Link]
2017
YY Yan, S Hartono, T Hennedige, TS Koh, CM Chan, L Zhou, H Rumpel, L Martarello, JB Khoo, DM Koh, KH Chuang, KH Tony Lim, YY Dan, CH Thng. "Intravoxel incoherent motion and diffusion tensor imaging of early renal fibrosis induced in a murine model of streptozotocin induced diabetes." Magn Reson Imaging. 38:71-76, 2017. [Link]
A Ulyanova, XV To, A.B.M.A. Asad, W Han, KH Chuang. “MEMRI detects neuronal activity and connectivity in hypothalamic neural circuit.” NeuroImage, 147: 904-15, 2017 [Link]
FA Nasrallah, KK D/O R Singh, LY Yeow, KH Chuang. “GABAergic effect on resting-state functional connectivity: dynamics under pharmacological antagonism.” NeuroImage, 149: 53–62, 2017 [Link].
X Hong, YZ Ong, I Teh, FA Nasrallah, ZK Lu, WP Teo, C Guan, KK Ang, KS Phua, CW Chen, E Chew, KH Chuang. “Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study.” Scientific Reports, 7(1):9222, 2017 [Link].
CW Zhang, YK Tai, BH Chai, KCM Chew, ET Ang, F Tsang, BWQ Tan, ETE. Hong, ABMA Asad, KH Chuang, KL Lim, TW Soong. “Transgenic Mice Overexpressing The Divalent Metal Transporter 1 Exhibit Iron Accumulation in The Brain But No Overt Signs of Neurodegeneration.” NeuroMolecular Medicine, 19: 375-386, 2017. [Link]
KH Chuang, FA Nasrallah. "Functional networks and network perturbations in rodents." NeuroImage, 163:419-436, 2017. [Link] [PDF]
2016
B Zhang, KH Chuang, G Tjio, WC Chen, FS Sheu, A Routtenberg. “Spatial memory training induces morphological changes detected by Manganese-Enhanced MRI in the hippocampal CA3 mossy fiber terminal zone.” NeuroImage,128:227-237, 2016 [Link]
FA Nasrallah, XV To, DY Chen, A Routtenberg, KH Chuang. “Functional connectivity MRI tracks memory networks after maze learning in rodents.” NeuroImage, 127:196-202, 2016. [Link]
M Sobczak-Edmans, TH Ng, YC Chan, E Chew, KH Chuang, SH Chen. Temporal dynamics of visual working memory. Neuroimage. 124(Pt A):1021-30, 2016. [Link]
HB Ng, KL Kao, YC Chan, E Chew, KH Chuang, SH Chen. “Modality Specificity in the Cerebro-cerebellar Neurocircuitry During Working Memory.” Behav. Brain Res. doi: 10.1016/j.bbr.2016.02.027. [Link]
Teo RT, Hong X, Yu-Taeger L, Huang Y, Tan LJ, Xie Y, To XV, Guo L, Rajendran R, Novati A, Calaminus C, Riess O, Hayden MR, Nguyen HP, Chuang KH, Pouladi MA. "Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease." Hum Mol Genet. 2016 [Link]
Attia AB, Ho CJ, Chandrasekharan P, Balasundaram G, Tay HC, Burton NC, Chuang KH, Ntziachristos V, Olivo M. "Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma." J Biophotonics. 2016. [Link]
Liu XL, Ng CT, Chandrasekharan P, Yang HT, Zhao LY, Peng E, Lv YB, Xiao W, Fang J, Yi JB, Zhang H, Chuang KH, Bay BH, Ding J, Fan HM. "Synthesis of Ferromagnetic Fe0.6 Mn0.4 O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T1 -T2 Dual-Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy." Adv Healthc Mater. 2016 [Link]
Garcia-Miralles M, Hong X, Tan LJ, Caron NS, Huang Y, To XV, Lin RY, Franciosi S, Papapetropoulos S, Hayardeny L, Hayden MR, Chuang KH, Pouladi MA. "Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease." Sci Rep 2016 [Link]
Nasrallah FA, To XV, Chen DY, Routtenberg A, Chuang KH. "Resting state functional connectivity data supports detection of cognition in the rodent brain." Data Brief. 2016 [Link]
Yan YY, Hartono S, Hennedige T, Koh TS, Chan CM, Zhou L, Rumpel H, Martarello L, Khoo JB, Koh DM, Chuang KH, Tony Lim KH, Dan YY, Thng CH. "Intravoxel incoherent motion and diffusion tensor imaging of early renal fibrosis induced in a murine model of streptozotocin induced diabetes." Magn Reson Imaging. 38:71-76, 2016. [Link]
I Parikh, J Guo, KH Chuang, V Bakshi, Y Zhong, RG Rempe, B Bauer, AMS Hartz, AL Lin. “Caloric restriction preserves learning and memory of aging mice with early enhancement of cerebral blood flow and blood-brain barrier integrity.” Aging, 8:2814-2826, 2016 [Link]
AW Jackson, P Chandrasekharan, B Ramasamy, J Goggi, KH Chuang, T He, EG Robins. “Octreotide Functionalized Nano-Contrast Agent for Targeted Magnetic Resonance Imaging.” Biomacromolecule, 17:3902-3910, 2016. [Link]
2015
D Kokuryo, S Nakashima, F Ozaki, E Yuba, KH Chuang, S Aoshima, Y Ishizaka, T Saga, K Kono, I Aoki. “Evaluation of Thermo-triggered Drug Release in Intramuscular-transplanted Tumors using Thermosensitive Polymer-modified Liposomes and MRI.” Nanomedicine. 11:229-238, 2015. [Link]
P Chandrasekharan, CT Yang, FA Nasrallah, HC Tay, KH Chuang, EG Robins. “Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic tumor model.” Contrast Media Mol Imaging. 10:237-44, 2015. [Link]
R Rajendran, JM Liang, S Choo, B Henry, KH Chuang. “Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model.” NMR Biomed, 28:988-97, 2015 [Link]
FA Nasrallah, LY Yeow, B Biswal, KH Chuang. “Dependence of BOLD signal fluctuation on arterial blood pCO2 and pO2: implication for resting-state functional connectivity.” NeuroImage, 117:29-39, 2015.[Link]
X Hong, XV To, I Teh, JR Soh, KH Chuang. “Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field.” Magn Reson Imaging, 33(9):1098-105, 2015 [Link]
Yinghui Li, Qiling Zhou, Wenjie Sun, Prashant Chandrasekharan, Hui Shan Cheng, Zhe Ying, Manikandan Lakshmanan, Anandhkumar Raju, Daniel Tenen, Sh-Yuan Cheng, Kai-Hsiang Chuang, Jun Li, Shyam Prabhakar, Mengfeng Li, and Vinay Tergaonkar. "Non-canonical NF-κB signalling and ETS1/2 co-operatively drive C250T mutant TERT promoter activation" Nature Cell Biology, 17:1327-38, 2015. [Link]
Hennedige T, Koh TS, Hartono S, Yan YY, Song IC, Zheng L, Lee WS, Rumpel H, Martarello L, Khoo JB, Koh DM, Chuang KH, Thng CH. Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction. Magn Reson Imaging. 33:1324-8, 2015. [Link]
2014
FA Nasrallah, SK Lew, A Low, KH Chuang. “Neural correlate of resting-state functional connectivity under α2 adrenergic agonist, medetomidine.” NeuroImage, 84:27-34, 2014 [Link].
FA Nasrallah, HC Tay, KH Chuang. “Detection of functional connectivity in the resting mouse brain.” NeuroImage, 86:417–424, 2014 [Link]
CT Yang, P Chandrasekharan, T He, Z Poh, A Raju, KH Chuang, EG Robins. “An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography.” Biomaterials, 35:327-36, 2014. [Link]
R Rajendran, CM Liang, MY Tang, S van Boxtel, S Choo, A Cliffe, K Rogers, S Rogers, B Henry, KH Chuang. “Early detection of anti-angiogenic treatment responses in mouse xenograft tumor model using quantitative perfusion mri.” Cancer Medicine, 3: 47–60, 2014. [Link]
W Cheng, R Rajendran, W Ren, L Gu, KH Chuang, Y Zhang, Y Liu. “A facile approach to biodegradable polydisulfide MRI contrast agent.” J Mater Chem B, 2: 5295-5301, 2014. [Link]
FA Nasrallah, A Low, SK Lew, K Chen, KH Chuang. “Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2 adrenergic agonist vs antagonist.” Neuroimage, 103:364-373, 2014. [Link]
2013
J Sundaram, C Poore, NH Sulaimee, T Pareek, ABMA Asad, R Rajkumar, GS Dawe, KH Chuang, H Pant, S Kesavapany. "Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration in vivo." J Neurosci, 33:334-43, 2013. [Link]
ESG Choo, E Peng, R Rajendran, J Ding, KH Chuang, JM Xue. "Superparamagnetic Nanostructures for Off-Resonance Magnetic Resonance Spectroscopic Imaging." Advanced Functional Materials, 23: 496–505, 2013. [Link]
F Yuan, KH Chuang, J Liu. "A Variational Surface Deformation and Subdivision Based Modeling Framework For Noisy and Small n-Furcated Tube-Like Structures." IEEE Trans Biomed Eng, 60(6):1589-98, 2013. [Link]
J Zhong, A Rifkin-Graboi, AT Ta, KL Yap, KH Chuang, MJ Meaney, A Qiu. "Functional Networks in Parallel with Cortical Development Associate with Executive Functions in Children." Cereb Cortex, in press. [Link]
Cheng W, Ping Y, Zhang Y, Chuang KH, Liu Y. "Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis." J Healthc Eng. 4:23-45, 2013. [Link]
R Rajendran, SK Lew, CX Yong, J Tan, DJJ Wang, KH Chuang. "Quantitative mouse renal perfusion using arterial spin labeling." NMR Biomed, 26:1225-32, 2013 [Link].
FA Nasrallah, G Pagès, PW Kuchel, X Golay, KH Chuang. "Imaging brain deoxyglucose uptake and metabolism by gluco-CEST MRI", J Cereb Blood Flow Metab, 33:1270-8, 2013 [Link].
2012
PW Kuchel, G Pagès, K Nagashima, S Velan, V Vijayaragavan, V Nagarajan, KH Chuang. "Stejskal–tanner equation derived in full." Concepts Magn Reson, 40A: 205–214, 2012. [Link]
Chandrasekharan P, Yong CX, Poh Z, He T, He Z, Liu S, Robins EG, Chuang KH, Yang CT. "Gadolinium chelate with DO3A conjugated 2-(diphenylphosphoryl)-ethyldiphenylphosphonium cation as potential tumor-selective MRI contrast agent." Biomaterials 33(36):9225-31, 2012. [Link]
Peng E, Choo ES, Chandrasekharan P, Yang CT, Ding J, Chuang KH, Xue JM, "Synthesis of Manganese Ferrite/Graphene Oxide Nanocomposites for Biomedical Applications." Small 8:3620-30, 2012. [Link]
CT Yang, KH Chuang. "Gd(III) Chelates for MRI Contrast Agents: from High Relaxivity to Smart, from Blood-Pool to Blood-Brain Barrier Permeable." Med Chem Commun, 3:552-565, 2012.
FA Nasrallah, J Tan, KH Chuang. "Pharmacological modulation of functional connectivity: α2 adrenergic receptor agonist alters synchrony but not neural activation." NeuroImage, 60(1):436-46, 2012.[Link]
FA Nasrallah, EL Lee, KH Chuang. Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain. NMR Biomed 25(11):1209-16, 2012. [Link]
J Bai, TTL Huong, KH Chuang, A Qiu. "Atlas-based Automatic Mouse Brain Image Segmentation Revisited: Model Complexity vs Image Registration." Magn Reson Imag, 30(6):789-98, 2012. [Link]
C Leuze, Y Kimura, J Kershaw, S Shibata, KH Chuang, T Saga, I Shimoyama, I Aoki. "Quantitative measurement of changes in neural activity in vivo utilizing dynamic manganese- enhanced MRI (dMEMRI)." NeuroImage, 60(1):392-9, 2012. [Link]
2011
YF Tan, P Chandrasekharan, M Dipak, CX Yong, KH Chuang, Y Zhao, S Wang, J Ding, SS Feng. "Multimodal tumor imaging by iron oxides (IOs) and quantum dots (QDs) formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) nanoparticles." Biomaterials 32:2969-78, 2011. [Link]
S Saito, I Aoki, K Sawada, XZ Sun, KH Chuang, J Kershaw, I Kanno, T Suhara. "Quantitative and noninvasive assessment of radiation induced encephalodysplasia using magnetic resonance imaging." Radiation Research 175:1-9, 2011 [Link]
N Chou, J Wu, J Bai, A Qiu, KH Chuang. "Robust automatic rodent brain extraction using 3D Pulse-coupled Neural Networks (PCNN)." IEEE Trans Imag Proc 20:2554-64, 2011 [Link]
K Kittigowittana, CT Yang, WC Cheah, KH Chuang, CY Tuang, YT Chang, X Golay, RW Bates. "Development of Intravascular Contrast Agents for MRI Using Gadolinium Chelates." ChemMedChem 6:781-7, 2011. [Link]
P Chandrasekharan, D Maity, CX Yong, KH Chuang, J Ding, SS Feng. "Vitamin E (d-alpha-tocopheryl-co-poly(ethylene glycol) 1000 succinate) micelles- superparamagnetic iron oxide nanoparticles for enhanced thermotherapy and MRI." Biomaterials. 32:5663-72, 2011. [Link]
D Maity, P Chandrasekharan, P Pradhan, KH Chuang, JM Xue, SS Feng, J Ding. 「Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications.」 J Mater Chem 21:14717-24, 2011. [Link]
Hartono S, Thng CH, Ng QS, Yong CX, Yang CT, Shi W, Chuang KH, Koh TS. "High temporal resolution dynamic contrast-enhanced MRI at 7 Tesla: a feasibility study with mouse liver model." Conf Proc IEEE Eng Med Biol Soc. 2011:2788-91. [Link]
2010
D Maity, P Chandrasekharan, CT Yang, KH Chuang, B Shuter, JM Xue, J Ding, SS Feng. "Facile Synthesis of Water-Stable Fine Magnetite Nanoparticles for MRI and Magnetic Hyperthermia Applications." Nanomedicine 5(10):1571-84, 2010. [Link]
W Han, KH Chuang, YT Chang, M Olivo, S Velan, K Bhakoo, D Townsend, GK Radda. "Image Metabolic Syndrome." EMBO Molecular Medicine 2(6):196-210, 2010. [Link]
C Prashant, M Dipak, CT Yang, KH Chuang, D Jun, SS Feng. "Super-paramagnetic iron oxide - Loaded poly (lactic acid)-d-alpha-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent." Biomaterials 31:5588-97, 2010. [Link]