A multi-center, randomized, double-blind, parallel-group, placebo-controlled 24-week study to evaluate efficacy and safety of XXXX compared to placebo in patients with resistant hypertension
Summary: Study XXXX will be a multicenter, randomized, double-blind, placebo-controlled, parallel-group study designed to demonstrate superiority of XXXX over placebo in reducing blood pressure in subjects with resistant hypertension. The study will consist of four periods: 1 week screening, 2-4 weeks single blind run-in, 24-week double-blind treatment and 8 week follow-up period. At the end of the Run-in period, participants whose 24hr mean SBP is ≥135 mmHg using ABPM despite compliance with study treatment and background AHMs will be randomized in a 1:2 ratio to receive placebo or XXXX mg s.c. q4w for the randomized treatment period.
Summary: Study XXXX will be a multicenter, randomized, double-blind, placebo-controlled, parallel-group study designed to demonstrate superiority of XXXX over placebo in reducing blood pressure in subjects with resistant hypertension. The study will consist of four periods: 1 week screening, 2-4 weeks single blind run-in, 24-week double-blind treatment and 8 week follow-up period. At the end of the Run-in period, participants whose 24hr mean SBP is ≥135 mmHg using ABPM despite compliance with study treatment and background AHMs will be randomized in a 1:2 ratio to receive placebo or XXXX mg s.c. q4w for the randomized treatment period.
Type of study (PIC, Recruiting): Recruiting
Type of study (PIC, Recruiting): Recruiting
Commercial Study - Site Identification form required to be completed, please find Site ID form uploaded to study documents link below.
Commercial Study - Site Identification form required to be completed, please find Site ID form uploaded to study documents link below.
Recruitment Duration: 01/01/2026- /31/10/2027
Recruitment Duration: 01/01/2026- /31/10/2027
Practice Activity: See part B and Schedule of Events
Practice Activity: See part B and Schedule of Events
Practice Eligibility Criteria: GP practices within East Midlands
Practice Eligibility Criteria: GP practices within East Midlands
Practice Target: 3 per site
Practice Target: 3 per site
Is this Study Applicable for RSI Scheme?
Is this Study Applicable for RSI Scheme?
Yes, applicable for RSI scheme
Research Costs:
Research Costs:
Commercial research studies follow a national tariff guideline. Click here for more information on the tariff or download the tariff by clicking here
Commercial research studies follow a national tariff guideline. Click here for more information on the tariff or download the tariff by clicking here