Duncan Buckerfield
AP Biology
2021
Mr. Danny Tamburro
Senior Year - Investigate the World: What is the evidence that a student can initiate investigations of the world by framing questions, analyzing and synthesizing relevant evidence, and drawing reasonable conclusions about global issues?\
This AP Bio project focused on the HIV vaccine that is in development. The mRNA method of vaccinations has been especially prevalent throughout the COVID-19 pandemic, and study of this particular type of vaccine has led to new research on a possible HIV vaccine. Moderna is in development of a HIV RNA Vaccine similar to their Covid-19 Vaccine. It has shown promise in early trials. Also, VRCO1 is a collaboration from a multitude of nonprofits and universities on the development of an antibody reaction which has proven successful.
So, how does it work? First the mRNA provides cells with instructions to create a protein that is similar to the virus Then, proteins condition the immune system to recognize and fight the virus. Which works by triggering B-cells (WBCs that fight viruses) and quickening function of bnAb (neutralizing antibody). Currently there are 2 active Moderna human trials, healthy participants will be injected to test the safety. Larger Clinical Trials to begin soon to determine widespread effectivity. In the next 5 years, approval for wide scale use in especially vulnerable population. Research continues as results from small trials begin rolling in. Within 10-15 years a vaccine will be rolled out across the population.
This investigation of rapid medical advancement in the HIV scene is incredibly important in the eradication of the disease around the world. Especially in areas with limited heath care facilities. This aligns with the ISSN's goals of investigating the world because it allows for the students to understand and then teach others about the need for continued investment in biotechnology. It will be interesting to see where this goes.