sdj-10022

Prevalence of orofacial changes in patients with β-thalassemia major in Karbala City, Iraq

Muhanned Salah Abulsattar* & Ali Mihsen Al-Yassiri**

*College of Dentistry, University of Karbala

**College of Dentistry, University of Babylon

DOI: https://doi.org/10.17656/sdj.10022

Abstract

Objectives: The aim of this study was to investigate findings of oral abnormalities or changes in these patients, and compare it to healthy control subjects.

Materials and Methods: Patients were selected from Thalassemia Center of Pediatric of Al Hussaini Teaching Hospital in Holy-Karbala during the period from March to September 2013. Forty (40) subjects were incorporated in this study. All these patients with age range (4-15) years, (22 males, and 18 females). All these patients were without any other systemic diseases. 

Results: The prevalence of orofacial complications in β-thalassemia major patients was: prominent maxilla (85%), bad oder (80%), oral ulcers (50%), angular stomatitis (40%), candidal infection (35%), changes in oral mucosa (30%), xerostomia (15%), and the last one was enlargements of salivary glands (zero).

Conclusions: Knowing the prevalence of complication can help the dentists to do properly for these patients to solve their problems and improve knowledge of the parents about their children's dental health.

Keywords: Orofacial changes , major β-thalassemia, prominent maxilla.

Full Article - PDF

References:

1.    Braun wald, Antony S fuci, Kasper, Hauser, Longo, Jameson: Harrison's principle of internal medicine. 15th ed. New York, Mc-Grow Hill. pp, 2001;666-74.

2.    Malcolm A, Martin S Greenberg: Burket's oral medicine. 9th ed. Philadeiphia, Lippincott. pp. 1994:534-9.

3.    Farhud D, Sadighi H. Investigation of prevalence of beta thalassemia in Iranian provinces. Iranian J Pub Health. 1997: 26:3-6. 

4.    Miller. Blood disease in infancy childhood. 3rd ed . London, Mosby. pp. 1989:280-340.

5.    Gerrnberg M S. Burket's oral medicine. 10th ed. Philadelphia, Lippincott, pp. 2003: 430-6.

6.    Margot L, Van Dis. Thalassemia. oral manifestations and complications. Oral Med, Oral Path, Oral Surg.1986; 62:229-33.

7.    Modell B, Berdoukas V. The clinical approach to thalassemia. New York, Grune and Stratton,pp, 1984; 53-75.

8.    Lawson JP, Ablow RC, Pearson HA. The ribs in thalassemia. I, The relasioship to therapy. Radiology. 1981; 140:663-77.

9.    Poynton HG. Oral radiology, Baltimore, Williams and Wilkins, pp, 1982; 230-2.

10.  Martin S. Greenberg, Adi  Garfukel. Hematologic Disease, Thalassemias, Diagnosis and Treatment, Burket's Oral Medicine 9th ed, 1994; 536-7.

11.  Ernest Butler. Hemoglobinopathies, thalassemia syndromes, Harrison's Principles of Internal Medicine. McGraw-Hill. 15th ed, 2001; 106:668-74.

12.  De Mattia D, Pettini PL, Sabato V, Rubini G, Laforgia A, Schettini F. Oromaxillofacial changes in thalassemia major. Minerva Pediatr. 1996;48:11-20.

13.  Al-Kaysi GH. Dental and oral changes in a group of Iraqi thalassemia patients, the first scientific congress on thalassemia and hemoglobin pathies. Baghdad, 2002.

14.  Duggal MS, Bedi R, Kinsey SE, Williams SA. The dental management of children with sickle cell disease and beta-thalassaemia: a review. Int J Paediatr Dent. 1996;6:227-34.

15.  Goldfarb A, Nitzan DW, Marmary Y. Changes in the parotid salivary gland of beta-thalassemia patients due to hemosiderin deposits. Int J Oral Surg. 1983;12:115-9.

16.  Olivieri NF. The beta-thalassemias. N Engl J Med. 1999 ;341:99-109.

17.  Sonis, Fazio, Fang, Pigmented lesions. Hemochromatosis, Principles and Practice of Oral Medicine, 2nd ed, 1984;38;385.

    

18.  Margot L. Van Dis, and Robert P. Langlais. The thalassemia: Oral manifestations and complications. Oral Surg. Oral Med, Oral Pathol. 1996;62:229-33.  

19.  Weatherall JD, Clegg JB. The thalassemia syndromes (3rd edn). Oxford: Blackwell, pp, 1981; 132-74.

20.  Modell B. Management of thalassemia major. Br Med Bull. 1976;  32: 270-6.

21.  Weel F, Jackson IT, Crookendale WA, McMichan J. A case of thalassemia major with gross dental and jaw deformities. Br J Oral Maxillofac Surg. 1987;25:348-52.

22.  Kaplan RI, Werther R, Castano FA. Dental and oral findings in Cooley's anemia: a study of fifty cases. Ann NY Acad Sci. 1964; 119:664-6.

23.  Van Dis ML, Langlais RP. The thalassemias: oral manifestations and complications. Oral Surg Oral Pathol. 1986; 62:229-33.

24.  Caffey J. Cooley's anemia: a review of the rontgenographic finding in the skeleton. Am J Roentgenol Radium Ther Nucl Med. 1957; 78:381-91.

25.  Baker D. H. Roentgen manifestations of Colley's anemia, Ann.N. Y. Acad of Sci. 1964;119:641-61.

26.  Jonston FE, Kogman WM. Patterns of growth in children with thalassemia major. Ann N Y Acad Sci. 1964;119:667-79

27.  Lynch M.A: Hematologic diseases, Diagnosis and treatment of Hematologic diseases, Burket's Oral Medicine, 7th ed, 1973; 203-409.

28.  Sreebny LM, Valdini A. Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol. 1988;66:451-8.

29.  Hattab FN, Hazza'a AM, Yassin OM, al-Rimawi HS. Caries risk in-patients with thalassemia major. Int Dent J. 2001; 51: 35-8.

30.  Abbott M, Galloway A, Cunningham JL. Haemochromatosis presenting with a double Yersinia infection. J

Infect. 1986;13:143-5

 © The Authors, published by University of Sulaimani, College of Dentistry

This work is licensed under a Creative Commons Attribution 4.0 International License.