The Library is a member of the International Federation of Library Associations and Institutions (IFLA), one of the leading international associations of library organizations. It is the global voice of the library and information profession. Its annual conference provides a venue for librarians to learn from one another. The IFLA forum promotes international cooperation, research and development in all fields related to library activities.

The American Corner-Xavier University in Cagayan de Oro is recognized as one of the few priority American Spaces in the world and the very first in the Philippines. It has been active and effective in providing current and useful information, including but not limited to, Education, Economics, Management, Business, American Studies, Literature, English Teaching, English Language, Politics, Law and Democratic Societies.

The Library is a member of the Jesuit Higher Education Institutions Library Consortium JHELCon namely: Ateneo de Davao University, Ateneo de Manila University, Ateneo de Naga University, Ateneo de Zamboanga University, Loyola School of Theology, Loyola College of Cullion and St John Vianney Theological Seminary. Its main purpose is to use group purchasing power for licensing digital resources; use group purchasing power to purchase a common library system for all members when resources become available; provide access to and share information resources held across all the member libraries; provide support and training for its members; and share best practices in providing information services to its users.

The Library is a member of the Academic Libraries Book Acquisition Systems Association, Inc. (ALBASA), a non-profit organization that aims to engage in a joint, coordinated program of library book purchasing and to provide a clearinghouse for various cooperative activities among members.

The Library is a member of the Academic Libraries Information Network in Mindanao (ALINET) since it was founded in 1988. It has been involved in several activities geared towards the improvement of the library services of the member libraries. Its original concept of bibliographical and physical access to each library’s holdings is still the heart of inter-library cooperation. Thousands of students from each member institution have benefited from the resources made available to them. 

The Library participates in the Consortium of Engineering Libraries in the Philippines (CELPh). The aim is to allow participating libraries to share resources online and provide better access to the shared collection at a lower cost; to upgrade the professional and personal competencies of its members; to share information on professional issues, best practices and appropriate technical services.

The Library also participates in “Kultura link: Libraries for Culture and the Arts” a flagship project of the National Committee on Libraries and Information Services (NCLIS) in consonance with the National Commission for Culture and the Arts (NCCA). It envisions to link libraries with culture and art collection through collaboration and networking strategies among and between the cultural agencies and university-based libraries.

The Library supports and participates in a Directory of Open Access Journal (DOAJ). It aims to increase the visibility and ease of use of open access scientific and scholarly journals, thereby promoting their increased usage and impact. It also aims to be comprehensive and cover all open access scientific and scholarly journals that use a quality control system to guarantee the content.

The Library is a member of Medical and Health Librarians Association of the Philippines. MAHLAP is a national association of medical and health librarians founded on May 1987. Its objectives are to encourage and promote the collection, organization and dissemination of medical health information and library service; encourage and cultivate library cooperation, local and regional; and to enhance and uphold the dignity and ethics of the medical and health librarianship. 

The Library is also a member of the Philippine Association of Academic and Research Librarians, better known by its acronym, PAARL. It is an association of academic and research librarians in the Philippines that upholds the profession of academic and research librarianship in the country. Its principal mission is to articulate the concerns of academic and research librarians and their institutions, and to influence information policy development affecting the future of academic and research libraries. Since 1973, it has provided leadership in the development and growth of library and information services in the country.