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Nature reviews urology paper is out!
Our recent publication in Nature Reviews Urology offers insights into the intricate interplay between high-fat diets, metabolic disorders, and their impact on testicular metabolism and spermatogenesis. Furthermore, we explore the intricate mechanisms through which metabolic disorders shape the epigenetic landscape of male gametes. This exploration unveils a potential avenue for understanding how phenotype traits could be transmitted across generations, shedding light on the broader implications of metabolic health beyond individual well-being. Have a look here!
David Carrageta has just defended his PhD Thesis!
David Carrageta recently completed his doctoral defense, presenting his thesis entitled: "Metabolic Modulation of Mitochondrial Uncoupling Proteins and Insulin on Human Spermatozoa and Sertoli Cells." Spanning 8 peer-reviewed papers, one of which was published in Nature Reviews Urology, David delves into the nuanced interplay of metabolic and hormonal factors influencing male fertility. Congratulations!
Mitochondrial quality in endothelial cells and oxidative stress in preeclampsia: new Paper out!
We're excited to announce the publication of our recent paper in the Vascular Pharmacology Journal, which delves into the application of real-time analyzers for assessing mitochondrial quality in endothelial cells and oxidative stress in preeclampsia. Our findings underscore the importance of conducting comprehensive investigations to shed light on the complexities of mitochondrial dynamics within the realm of this pregnancy-related disorder. Have a look here!
Metabolomics of Human Seminal Fluid paper published!
Our new paper published in Journal of Biological Regulators and Homeostatic Agents describes a propensity for increased levels of various amino acids in seminal fluid with advancing age. The paper provides compelling evidence of age exerting a discernible influence on the comprehensive seminal metabolome. Have a look here!
New Paper on Antioxidants Journal!
We are pleased to announce the publication of our paper titled "Impact of Chromium Picolinate on Leydig Cell Steroidogenesis and Antioxidant Balance Using an In Vitro Insulin Resistance Model." This study underscores the importance of caution when considering the use of chromium picolinate, even at lower doses. We uncovered mechanisms of the complex interplay between chromium picolinate and Leydig cell metabolism, as well as antioxidant defenses. We show potential benefits and risks associated with chromium picolinate use, particularly in the context of insulin resistance, in Leydig cells which are known for producing testosterone! Have a look here!
Paper coming out on Metabolomics Integration in Assisted Reproductive Technologies!
In this study, we have integrated metabolomics with the standardized morphological classification of embryos to pinpoint biomarkers that can enhance the selection of optimal embryos for transfer. During the initial 3 days of culture, Good and Lagging embryos were observed to export and accumulate pyruvate and glutamine, whereas Bad embryos exhibited a consumption pattern for these metabolites. This indicates that Bad embryos display lower metabolic activity compared to their Good and Lagging counterparts, with pyruvate and glutamine emerging as potential biomarkers for assessing embryo quality. The synergistic application of morphological assessment and metabolomics promises a more precise and consistent identification of high-quality embryos, thereby enhancing the likelihood of successful pregnancies. You can read it here.
New collaboration paper on lung adenocarcinoma is out!
We participated in a metabolomics-based study in patients with lung adenocarcinoma. Although our initial pursuit aimed at identifying metabolomic patterns to forecast individual outcomes of chemotherapy and immunotherapy, no distinct pattern emerged within our sample. Nonetheless, our discoveries illuminate a potential avenue for further exploration. Notably, the suggestion that higher glucose levels and lower lactate levels throughout chemotherapy may be correlated with favorable tumor response warrants deeper investigation. Conversely, lower levels of alanine seem to be indicative of greater frailty, disease progression, and an unfavorable prognosis. You can read it here.
New Paper on Nutrients is out!
In the past few decades, the surging incidence of metabolic disorders, particularly obesity and overweight conditions, has become a prominent issue in public health. An intriguing hypothesis emerges when considering transgenerational inheritance—the idea that genetic and epigenetic imprints linked to obesity might exert a significant impact on the onset of Prostate Cancer. This paper delves into the intricate mechanisms by which obesity disrupts prostate homeostasis, acting as a catalyst for the initiation of prostate cancer. Additionally, we explore the fascinating interplay between the transgenerational transmission of obesity-related traits and the predisposition to prostate cancer. You can read it here.