Publications

2024

Gomes-Andrade D, Guerra-Carvalho B, Carrageta DF, Bernardino RL, Braga PC, Oliveira PF, Pereira ML, Alves MG. Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase, Toxicology and Applied Pharmacology, Volume 486, 2024. https://doi.org/10.1016/j.taap.2024.116929

Carrageta DF, Pereira SC, Ferreira R, Monteiro MP, Oliveira PF, Alves MG. Signatures of metabolic diseases on spermatogenesis and testicular metabolism. Nat Rev Urol, 2024. https://doi.org/10.1038/s41585-024-00866-y

Priscila R. Nunes, Pedro F. Oliveira, Irene Rebelo, Valeria C. Sandrim, Marco G. Alves, Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia, Vascular Pharmacology, Volume 155, 2024, 107372. https://doi.org/10.1016/j.vph.2024.107372.

Guerra-Carvalho B, Jarak I, Carvalho RA, Pinto S, Correia SC, Barros A, Alves MG, Oliveira PF. Metabolomics of Human Seminal Fluid Reveals Aging-Related Increase in the Amino Acid Content. Journal of Biological Regulators and Homeostatic Agents. 2024, 38(4): 2945-2958 https://doi.org/10.23812/j.biol.regul.homeost.agents.20243804.230

Moreira R, Martins AD, Ferreira R, Alves MG, Pereira MdL, Oliveira PF. Impact of Chromium Picolinate on Leydig Cell Steroidogenesis and Antioxidant Balance Using an In Vitro Insulin Resistance Model. Antioxidants. 2024; 13(1):40. https://doi.org/10.3390/antiox13010040

Pinto S, Guerra-Carvalho B, Crisóstomo L, Rocha A, Barros A, Alves MG, Oliveira PF. Metabolomics Integration in Assisted Reproductive Technologies for Enhanced Embryo Selection beyond Morphokinetic Analysis. International Journal of Molecular Sciences. 2024; 25(1):491. https://doi.org/10.3390/ijms25010491

Madama, D.; Carrageta, D.F.; Guerra-Carvalho, B.; Botelho, M.F.; Oliveira, P.F.; Cordeiro, C.R.; Alves, M.G.; Abrantes, A.M. Impact of Different Treatment Regimens and Timeframes in the Plasmatic Metabolic Profiling of Patients with Lung Adenocarcinoma. Metabolites 2023, 13, 1180. https://doi.org/10.3390/metabo13121180

Santos-Pereira, M.; Pereira, S.C.; Rebelo, I.; Spadella, M.A.; Oliveira, P.F.; Alves, M.G. Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact. Nutrients 2023, 15, 4858. https://doi.org/10.3390/nu15234858

2023

Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Bernardino RL, Monteiro BS, Barros A., Oliveira PF, Monteiro MP, Alves MG. (2023). Mitochondrial uncoupling proteins regulate the metabolic function of human Sertoli cells. Reproduction (published online ahead of print 2023), REP-23-0229. Retrieved Dec 11, 2023, from https://doi.org/10.1530/REP-23-0229

Crisóstomo L, Oliveira PF, Alves MG. A systematic scientometric review of paternal inheritance of acquired metabolic traits. BMC Biol 21, 255 (2023). https://doi.org/10.1186/s12915-023-01744-6

Chaiyasoot K, Sakai NS, Zakeri R, Makaronidis J, Crisóstomo L, Alves MG, et al. Weight-loss Independent Clinical and Metabolic Biomarkers Associated with Type 2 Diabetes Remission Post-bariatric/metabolic Surgery. OBES SURG (2023). https://doi.org/10.1007/s11695-023-06905-8

Martins AD, Ribeiro JC, Ferreira R, Alves MG, Oliveira PF. Understanding the age-related alterations in the testis-specific proteome, Expert Review of Proteomics, 2023 DOI: 10.1080/14789450.2023.2274857

Luís C; Guerra-Carvalho B; Braga PC; Guedes C; Patrício E; Alves MG; Fernandes R; Soares R. The Influence of Adipocyte Secretome on Selected Metabolic Fingerprints of Breast Cancer Cell Lines Representing the Four Major Breast Cancer Subtypes. Cells 12,17. DOI: 10.3390/cells12172123

Costa J, Braga PC, Rebelo I, Oliveira PF, Alves MG. Mitochondria Quality Control and Male Fertility. Biology 12,6. DOI: 10.3390/biology12060827

Mateus FG, Moreira S, Martins AD, Oliveira PF, Alves MG, Pereira MdL. L-Carnitine and Male Fertility: Is Supplementation Beneficial? Journal of Clinical Medicine. 2023; 12(18):5796. https://doi.org/10.3390/jcm12185796

Braga PC, Bernardino RL, Guerra-Carvalho B, Carrageta DF, Oliveira PF, Rodrigues AS, Alves MG. The progression from mild to severe hyperglycemia coupled with insulin resistance causes mitochondrial dysfunction and alters the metabolic secretome of epithelial kidney cells. Experimental Cell Research. 2023. 113744. https://doi.org/10.1016/j.yexcr.2023.113744

Ribeiro JC, Bernardino RL, Gonçalves A, Barros A, Calamita G, Alves MG, Oliveira PF. Aquaporin-7-Mediated Glycerol Permeability Is Linked to Human Sperm Motility in Asthenozoospermia and during Sperm Capacitation. Cells. 2023; 12(15):2003. https://doi.org/10.3390/cells12152003

Moreira R, Martins AD, Alves MG, de Lourdes Pereira M, Oliveira PF. A Comprehensive Review of the Impact of Chromium Picolinate on Testicular Steroidogenesis and Antioxidant Balance. Antioxidants. 2023; 12(8):1572. https://doi.org/10.3390/antiox12081572

Monteiro J, Marks CA, Braga PC, Bernardino RL, Alves MG, Lobo-da-Cunha A, Videira A, Pereira F. The role of ion homeostasis imbalance due to citrate accumulation in fluoroacetic acid (FAA) toxicity in Neurospora crassa. Comp Biochem Physiol C Toxicol Pharmacol. 2023 May 18;271:109661. doi: 10.1016/j.cbpc.2023.109661

Morais T, Seabra AL, Patrício BG, Carrageta DF, Guimarães M, Nora M, Oliveira PF, Alves MG, Monteiro MP. Dysglycemia Shapes Visceral Adipose Tissue’s Response to GIP, GLP-1 and Glucagon in Individuals with Obesity. Metabolites. 2023; 13(5):587. https://doi.org/10.3390/metabo13050587

Bessa C, Loureiro JB, Barros M, Isca VMS, Sardão VA, Oliveira PJ, Bernardino RL, Herman-de-Sousa C, Costa MA, Correia-de-Sá P, Alves MG, Rijo P, Saraiva L. Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator. International Journal of Molecular Sciences. 2023; 24(6):5710. https://doi.org/10.3390/ijms24065710

Carrageta DF, Freire-Brito L, Guerra-Carvalho B, Ribeiro JC, Monteiro BS, Barros A, Oliveira PF, Monteiro MP, Alves MG. Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability. Antioxidants. 2023; 12(2):409. https://doi.org/10.3390/antiox12020409

Topete MV, Andrade S, Bernardino RL, Guimarães M, Pereira AM, Oliveira SB, Costa MM, Nora M, Monteiro MP, Pereira SS. Visceral Adipose Tissue Bioenergetics Varies According to Individuals’ Obesity Class. International Journal of Molecular Sciences. 2023; 24(2):1679. https://doi.org/10.3390/ijms24021679

Nunes DC, Ribeiro JC, Alves MG, Oliveira PF, Bernardino RL. Male Sex Hormones, Metabolic Syndrome, and Aquaporins: A Triad of Players in Male (in)Fertility. International Journal of Molecular Sciences. 2023; 24(3):1960. https://doi.org/10.3390/ijms24031960

2022

Ferreira AF, Santiago J, Silva JV, Oliveira PF, Fardilha M. PP1, PP2A and PP2B Interplay in the Regulation of Sperm Motility: Lessons from Protein Phosphatase Inhibitors. Int J Mol Sci. 2022 Dec 3;23(23):15235. doi: 10.3390/ijms232315235

Agarwal A, Cannarella R, Saleh R, Boitrelle F, Gül M, Toprak T, Salvio G, Arafa M, Russo GI, Harraz AM, Singh R, Garrido N, Hamoda TAAAM, Rambhatla A, Kavoussi P, Kuroda S, Çalik G, Saini P, Ceyhan E, Dimitriadis F, Henkel R, Crafa A, Palani A, Duran MB, Maziotis E, Saïs É, Bendayan M, Darbandi M, Le TV, Gunes S, Tsioulou P, Sengupta P, Hazir B, Çeker G, Darbandi S, Durairajanayagam D, Aghamajidi A, Alkhalidi N, Sogutdelen E, Leisegang K, Alarbid A, Ho CCK, Malhotra V, Finocchi F, Crisóstomo L, Kosgi R, ElBardisi H, Zini A, Birowo P, Colpi G, Park HJ, Serefoglu EC, Nguyen Q, Ko E, de la Rosette J, Pinggera GM, Nguyen HVP, Kandil H, Shah R (2022). Impact of Varicocele Repair on Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis. World Journal of Men’s Health, 40. doi:10.5534/wjmh.220142

Ribeiro JC, Bernardino RL, Carrageta DF, Soveral G, Calamita G, Alves MG, Oliveira PF. CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells. Cell Mol Life Sci. 2022 Nov 15;79(12):592. doi: 10.1007/s00018-022-04619-1. PMID: 36378343.

Boussada, M., Hammami, I., Ben Ali, R., Ammar, A. B., Alves, M., Oliveira, P. F., Akacha, A. B., Abdelkarim, I. L., Zekri, S., & El May, M. V. In vivo exposure to a new 2-cyano-2-p-nitrophenyl-N-benzylthioamide decreases doxorubicin-triggered structural damages in the mature testis. 2022. Andrologia, e14634. doi:10.1111/and.14634

Martin-Hidalgo D, González-Fernández L, Bragado MJ, Garcia-Marin LJ, Alves MG, Oliveira PF, The sirtuin 1 activator YK 3-237 stimulates capacitation-related events in human spermatozoa, Reproductive BioMedicine Online, 2022, ISSN 1472-6483, doi:10.1016/j.rbmo.2022.07.011.

Santos LLM, Alves MG, Chies A, Spadella M. Losartan Attenuates Radiation-Induced Damage on Testes and Accelerates Tubular Regeneration. Frontiers in Reproductive Health. 2022. 4. 904804. 10.3389/frph.2022.904804. 

Correia AS, Pereira SC, Morais T, Martins AD, Monteiro MP, Alves MG, Oliveira PF. Obesity-Related Genes Expression in Testes and Sperm Parameters Respond to GLP-1 and Caloric Restriction. Biomedicines. 2022 Oct 17;10(10):2609. doi: 10.3390/biomedicines10102609

Silva JV, Santiago J, Matos B, Henriques MC, Patrício D, Martins AD, Duarte JA, Ferreira R, Alves MG, Oliveira P, Oliveira PF, Fardilha M. Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testicular Function. Int J Mol Sci. 2022 Oct 1;23(19):11619. doi: 10.3390/ijms231911619

Silva R, Carrageta DF, Alves MG, Silva BM, Oliveira PF. Antioxidants and Male Infertility. Antioxidants 2022, 11, 1152. DOI: 10.3390/antiox11061152

Silva AM, Ribeiro CT, Bernardino RL, Jarak I, Carvalho RA, Pereira-Sampaio MA, de Souza DB, Alves MG, Oliveira PF. Stress Hormone Corticosterone Controls Metabolic Mitochondrial Performance and Inflammatory Signaling of In Vitro Cultured Sertoli Cells. Biomedicines. 2022 Sep 19;10(9):2331. doi: 10.3390/biomedicines10092331

Moreira S*, Silva R*, Carrageta DF*, Alves MG, Seco-Rovira V, Oliveira PF, Pereira ML. Carbamate Pesticides: Shedding Light on Their Impact on the Male Reproductive System. Int. J. Mol. Sci. 2022, 23(15), 8206. DOI: 10.3390/ijms23158206

Guerra-Carvalho B, Alves MG, Oliveira PF (2022) Obesity and Male Infertility: An Overview. Int J Diabetol Vasc Dis Res. 2022;8(1e):1-3. DOI: 10.19070/2328-353X

Alves AP, Rocha SM, Mamede AC, Braga PC, Alves MG, Oliveira PF, Botelho FM, Maia CJ. Differential response of hepatocellular carcinoma glycolytic metabolism and oxidative stress markers after exposure to human amniotic membrane proteins. Mol Biol Rep. 2022 Aug;49(8):7731-7741. doi: 10.1007/s11033-022-07598-5

Ribeiro JC, Martins AD, Jarak I, Carvalho RA, Alves MG, Oliveira PF (2022) Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key Metabolites for Spermatogenesis. Biomedicines, 10, 1115. doi: 10.3390/biomedicines10051115 

Silva R, Carrageta DF, Alves MG, Oliveira PF. Testicular Glycogen Metabolism: An Overlooked Source of Energy for Spermatogenesis? BioChem. 2022, 2, 198-214. DOI: 10.3390/biochem2030014

Carrageta DF, Freire-Brito L, Oliveira PF, Alves MG. Evaluation of human spermatozoa mitochondrial membrane potential using the JC-1 dye. Current Protocols, 2, e531. DOI: 10.1002/cpz1.531

Crisóstomo L, Oliveira PF, Alves MG (2022). Antioxidants, Oxidative Stress, and Non-Communicable Diseases. Antioxidants, 11(6):1080. doi:10.3390/antiox11061080

Carrageta DF*, Guerra-Carvalho B*, Spadella MA, Yeste M, Oliveira PF, Alves MG (2022) Animal models of male reproductive ageing to study testosterone production and spermatogenesis. Rev Endocr Metab Disord 2022. DOI: 10.1007/s11154-022-09726-9

Crisóstomo L, Bourgery M, Rato L, Raposo JF, Batterham RL, Kotaja N, Alves MG (2022). Testicular “inherited metabolic memory” of ancestral high-fat diet is associated with sperm sncRNA content. Biomedicines (Basel), 10(4):909. doi: 10.3390/biomedicines10040909

Pereira SC, Esperança IF, Pinto S, Barros A, Sousa M, Alves MG, Oliveira PF (2022) Pregnancy Achievement by Medical Assisted Reproduction Is Correlated to the G Protein-Coupled Receptor 30 mRNA Abundance in Human Spermatozoa. Appl. Sci. 2022, 12, 3240. DOI: 10.3390/app12073240

Moreira MV, Pereira SC, Guerra-Carvalho B, Carrageta DF, Pinto S, Barros A, Silva BM, Oliveira PF, Alves MG (2022) Hyperoside Supplementation in Preservation Media Surpasses Vitamin C Protection Against Oxidative Stress-induced Damages in Human Spermatozoa. Cell Physiol Biochem 2022;56(S1):1-23. DOI: 10.33594/000000487

Ribeiro JC, Carrageta DF, Bernardino RL, Alves MG, Oliveira PF (2022) Aquaporins and Animal Gamete Cryopreservation: Advances and Future Challenges. Animals 12(3):359. DOI: 10.3390/ani12030359

Pereira, PR, Carrageta, DF, Oliveira, PF, Rodrigues, A, Alves, MG, Monteiro, MP (2022) Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease. Med Res Rev. 2022; 1- 27. doi:10.1002/med.21883

Agarwal A, Finelli R, Durairajanayagam D, Leisegang K, Henkel R, Salvio G, Aghamajidi A, Sengupta P, Crisóstomo L, Tsioulou PA, Roychoudhury S, Finocchi F, Darbandi M, Mottola F, Darbandi S, Iovine C, Santonastaso M, Zaker H, Kesari KK, Nomanzadeh A, Gugnani N, Rambhatla A, Duran MB, Ceyhan E, Kandil H, Arafa M, Saleh R, Shah Rupin, Boitrelle F (2022) Comprehensive Analysis of Global Research on Human Varicocele: A Scientometric Approach. World Journal of Men's Health, 40. doi:10.5534/wjmh.210202

Crisóstomo L, Videira RA, Jarak I, Starčević K, Mašek T, Rato L, Raposo JF, Batterham RL, Oliveira PF, Alves MG (2022) Inherited Metabolic Memory of High-fat Diet Impairs Testicular Fatty Acid Content and Sperm Parameters. Molecular Nutrition & Food Research, 2100680. doi:10.1002/mnfr.202100680

2021

Monteiro BS*, Freire-Brito L*, Carrageta DF, Oliveira PF, Alves MG (2021). Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility? Antioxidants, 10(11), 1746. doi:10.3390/antiox10111746

Pereira SC, Oliveira PF, Oliveira SR, Pereira ML, Alves MG (2021). Impact of Environmental and Lifestyle Use of Chromium on Male Fertility: Focus on Antioxidant Activity and Oxidative Stress. Antioxidants, 10(9), 1365. doi:10.3390/antiox10091365

Ribeiro JC, Braga PC, Martins AD, Silva BM, Alves MG, Oliveira PF (2021). Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility. Antioxidants, 10(9), 1441. doi:10.3390/antiox10091441

Ribeiro JC, Nogueira-Ferreira R, Amado F, Alves MG, Ferreira R, Oliveira, PF (2021). Exploring the role of oxidative stress in sperm motility: a proteomics network approach. Antioxidants & Redox Signaling, 0(ja), null. doi:10.1089/ars.2021.0241

Guerra-Carvalho B*, Carrageta DF*, Crisóstomo L*, Carvalho RA, Alves MG, Oliveira PF (2021). Molecular mechanisms regulating spermatogenesis in vertebrates: Environmental, metabolic, and epigenetic factor effects. Animal reproduction science, 106896. doi:10.1016/j.anireprosci.2021.106896 

Minas A,  Talebi H, Ray MT, Eisalou MY, Alves MG, Razi M (2021). Insulin treatment to type 1 male diabetic rats protects fertility by avoiding testicular apoptosis and cell cycle arrest. Gene, 799, 145847. doi:10.1016/j.gene.2021.145847

Crisóstomo L, Jarak I, Rato L, Raposo JF, Batterham RL, Oliveira PF, Alves MG (2021). Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice. Sci Rep, 11(1), 9444. doi:10.1038/s41598-021-88981-3 

Pereira SC, Martins AD, Monteiro MP, Pinto S, Barros A, Oliveira PF, Alves MG (2021). Expression of obesity-related genes in human spermatozoa affects the outcomes of reproductive treatments. F&S Science. doi:10.1016/j.xfss.2021.03.004 

Loureiro JB, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima NR, Gomes C, Almeida MI, Alves MG, Costa JL, Santos MMM, Saraiva L. (2021). Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers, 13(7), 1648. doi:10.3390/cancers13071648 

Agarwal A, Finelli R, Selvam MK, Leisegang K, Majzoub A, Tadros N, Ko E, Parekh N, Henkel R, Durairajanayagam D, Colpi GM, Cho CL, Sallam HN, Park HJ, Saleh R, Micic S, Ambar RF, Zini A, Tremellen K, Alvarez JG, Palani A, Arafa M, Gava MM, Jindal S, Amar E, Kopa Z, Moein MR, Busetto GM, Sengupta P, Kavoussi P, Maldonado I, Fikri J, Borges E, Martinez M, Bojovic D, Rajmil O, Aydos K, Parekattil S, Marmar JL, Sefrioui O, Jungwirth A, Peña MG, Cordts EB, Elbardisi H, Mostafa T, Sabbaghian M, Gilani MA, Morimoto Y, Alves MG, Spasic A, Kenic U, Ramsay J, Akande EO, Oumeziane A, Dozortsev D, Chung E, Bell EG, Allegra A, Tanos V, Fiadjoe M, Gurgan T, Abou-Abdallah M, Al-Rumaih H, Oborna I, Arab H, Esteves S, Amer M, Kadioglu A, Yuzko O, Korsak V, Shah R. (2021) A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility. World Journal of Men's Health. 2021;39:e17. doi:10.5534/wjmh.210025

Ribeiro JC, Alves MG, Amado F, Ferreira R, Oliveira PF (2021) Insights and clinical potential of proteomics in understanding spermatogenesis. Expert Reviews in Toxicology. doi: 10.1080/14789450.2021.1889373

Agarwal A, Leisegang K, Panner Selvam MK, Durairajanayagam D, Barbarosie C, Finelli R, Sengupta P, Dutta S, Majzoub A, Pushparaj PN, Elbardisi H, Sharma R, Gupta S, Arafa M, Roychoudhury S, Alves MG, Oliveira PF, Henkel R (2021) An online educational model in andrology for student training in the art of scientific writing in the COVID-19 pandemic. Andrologia. e13961. doi: 10.1111/and.13961

Agarwal A, Leisegang K, Majzoub A, Henkel R, Finelli R, Panner Selvam MK, Tadros N, Parekh N, Ko EY, Cho CL, Arafa M, Alves MG, Oliveira PF, Alvarez JG, Shah R (2021) Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence. World Journal of Men's Health. doi: 10.5534/wjmh.200196

Correia SC, Machado NJ, Alves MG, Oliveira PF, Moreira PI (2021) Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 22(1):461. doi: 10.3390/ijms22010461

Crisóstomo L, Oliveira PF, Alves MG (2021) Sperm, metabolic memory, and echoes from Lamarck. European Journal of Clinical Investigation. doi:10.1111/eci.13492

Pereira SC, Martins AC, Moreira BP, Bernardino RL, Barros A, Monteiro MP, Oliveira PF, Alves MG (2021) Obesity-related genes are expressed in human Sertoli cells and modulated by energy homeostasis regulating hormones. Journal of Cellular Physiology, . doi:10.1002/jcp.30230

Ribeiro J C, Alves MG, Yeste M, Cho YS, Calamita G, Oliveira PF (2021). Aquaporins and (in)fertility: More than just water transport. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1867(3), 166039. doi:10.1016/j.bbadis.2020.166039

2020

Pereira SC*, Crisóstomo L*, Sousa M, Oliveira PF, Alves MG (2020) Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health. Environmental Epigenetics, 6. doi:10.1093/eep/dvaa019

Crisóstomo L, Videira RA, Jarak I, Starčević K, Mašek T, Rato LP, Raposo JF, Batterham RL, Oliveira PF, Alves MG (2020) Diet during early life defines testicular lipid content and sperm quality in adulthood. American Journal of Physiology-Endocrinology & Metabolism. 319: E1061–E1073. doi:10.1152/ajpendo.00235.2020

Moreira BP, Silva AM, Martins AD, Monteiro MP, Sousa M, Oliveira PF, Alves MG (2020) Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology. Reproductive Sciences, 10.1007/s43032-020-00328-x

Carrageta DF, Guerra-Carvalho B, Sousa M, Barros A, Oliveira PF, Monteiro MP, Alves MG (2020) Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli. Antioxidants, 9(8), 750. doi: 10.3390/antiox9080750

Agarwal A, Majzoub A, Baskaran S, Selvam MKP, Cho CL, Henkel R, Finelli R, Leisegang K, Sengupta P, Barbarosie C, Parekh N, Alves MG, Ko E, Arafa M, Tadros N, Ramasamy R, Kavoussi P, Ambar R, Kuchakulla M, Robert KA, Iovine C, Durairajanayagam D,Jindal S, Shah R (2020) Sperm DNA Fragmentation: A New Guideline for Clinicians. World Journal of Men's Health, 38:e44. doi: 10.5534/wjmh.200128

Crisóstomo L, Pereira SC, Monteiro MP, Raposo JF, Oliveira PF, Alves MG (2020) Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket? Molecular and Cellular Endocrinology, 110945. doi: 10.1016/j.mce.2020.110945

Pinto S*, Carrageta DF*, Alves MG, Rocha A, Agarwal A, Barros A, Oliveira PF (2020) Sperm selection strategies and their impact on assisted reproductive technology outcomes. Andrologia. e13725. doi:10.1111/and.13725

Pereira SS, Jarak I, Carvalho RA, Oliveira PF, Alves MG, Guimarães M, Almeida R, Pereira AM, Wewer Albrechtsen NJ, Holst JJ, Nora M, Monteiro MP (2020) Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures (2020) Obesity Surgery. doi:10.1007/s11695-020-04774-z

Mesquita G, Silva T, Gomes AC, Oliveira PF, Alves MG, Fernandes R, Almeida AA, Moreira AC, Gomes MS (2020) H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron. Scientific Reports;10(1):3061. doi:10.1038/s41598-020-59898-0

Martins AD, Panner Selvam MK, Agarwal A, Alves MG, Baskaran S (2020). Alterations in seminal plasma proteomic profile in men with primary and secondary infertility. Scientific Reports, 10(1), 7539. doi:10.1038/s41598-020-64434-1

Dias TR, Martín-Hidalgo D, Silva BM, Oliveira PF, Alves MG (2020). Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species. Antioxidants & Redox Signaling. doi:10.1089/ars.2019.7977

Moreira BP*, Silva JF*, Jarak I, de Lourdes Pereira M, Oliveira PF, Alves MG (2020) Technical-grade chlordane compromises rat Sertoli cells proliferation, viability and metabolic activity. Toxicology in vitro 63: 104673. doi:10.1016/j.tiv.2019.104673

Braga PC, Pereira SC, Ribeiro JP, Sousa M, Monteiro MP, Oliveira PF, Alves MG. Late-Onset Hypogonadism and Lifestyle-Related Metabolic Disorders (2020) Andrology. doi:10.1111/andr.12765

Silva JF, Moreira BP, Rato L, Pereira ML, Oliveira PF, Alves MG. Is Technical-grade Chlordane an Obesogen? (2020). Current Medicinal Chemistry. doi:10.2174/0929867327666200121122208

2019

Carrageta DF, Oliveira PF, Alves MG, Monteiro MP (2019) Obesity and male hypogonadism: Tales of a vicious cycle. Obesity Reviews. 20: 1148– 1158. doi: 10.1111/obr.12863

Jarak I, Pereira SS, Carvalho RA, Oliveira PF, Alves MG, Guimarães M, Albrechtsen NJW, Holst JJ, Nora M, Monteiro MP (2019) Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles. Obesity Surgery. doi:10.1007/s11695-019-04294-5

Carrageta DF, Bernardino RL, Soveral G, Calamita G, Alves MG, Oliveira PF (2019) Aquaporins and male (in)fertility: Expression and role throughout the male reproductive tract. Archives of Biochemistry and Biophysics. doi:10.1016/j.abb.2019.108222

Martins AD, Jarak I, Morais T, Carvalho RA, Oliveira PF, Monteiro MP, Alves MG (2019) Caloric restriction alters the hormonal profile and testicular metabolome resulting in alterations of sperm head morphology. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00355.2019

Crisóstomo L, Rato L, Jarak I, Silva BM, Raposo JF, Batterham RL, Oliveira PF, Alves MG (2019) A switch from high-fat to normal diet does not restore sperm quality but prevents metabolic syndrome. Reproduction 158(4), 377–387. doi: 10.1530/REP-19-0259

Boussada M, Dias TR, Crisóstomo L, Akacha AB, Ali RB, El May MV, Alves MG, Oliveira PF (2019) A new thiocyanoacetamide (2-cyano-2-p-nitrophenyl-N-benzylthioamide) reduces doxorubicin-induced in vitro toxicity in Sertoli cells by decreasing apoptosis and autophagy. Theriogenology 140, 188-200. doi: 10.1016/j.theriogenology.2019.08.030  

Martins AD, Oliveira PF, Alves MG (2019) Assessment of sertoli cell proliferation by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and sulforhodamine b assays. Current Protocols in Toxicology, 81, e85. doi: 10.1002/cptx.85  

Borges DO, Meneses MJ, Dias TR, Martins FO, Oliveira PF, Alves MG, Macedo MP (2019) Data on metabolic profile of insulin-degrading enzyme knockout mice. Data in Brief (DOI:10.1016/j.dib.2019.104023)  

Dias TR, Bernardino RL, Alves MG, Silva J, Barros A, Sousa M, Casal S, Silva BM, Oliveira PF (2019) L-theanine promotes cultured human Sertoli Cells proliferation and modulates glucose metabolism. European Journal of Nutrition (DOI:10.1007/s00394-019-01999-2) 

Bernardino RL, Carrageta DF, Sousa M, Alves MG, Oliveira PF. (2019) pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-019-03170-w

Bernardino RL, D'Souza WN, Rato L, Rothstein JL, Dias TR, Chui D, Wannberg S, Alves MG, Oliveira PF (2019) Knockout of MCT1 results in total absence of spermatozoa, sex hormones dysregulation, and morphological alterations in the testicular tissue. Cell & Tissue Research. 1-7. doi:10.1007/s00441-019-03028-4

Moreira BP, Oliveira PF, Alves MG (2019) Molecular Mechanisms Controlled by mTOR in Male Reproductive System. International Journal of Molecular Sciences. 20(7), 1633. DOI: 10.3390/ijms20071633

Meneses MJ, Borges DO, Dias TR, Martins FO, Oliveira PF, Macedo MP, Alves MG (2019) Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality. Mol Cell Endocrinol 486:11-17. doi:10.1016/j.mce.2019.02.011

Bernardino RL, Dias TR, Moreira BM, Cunha M, Barros A, Oliveira E, Sousa M, Alves MG, Oliveira PF (2019) Carbonic anhydrases are involved in mitochondrial biogenesis and control the production of lactate by human Sertoli cells. The FEBS Journal. (In press). DOI: 10.1111/febs.14779

Martins AD, Monteiro MP, Silva BM, Barros A, Sousa M, Carvalho RA, Oliveira PF, Alves MG (2019) Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1. Toxicol Appl Pharmacol. 362:1-8 (DOI: 10.1016/j.taap.2018.10.009) 

2018

Moreira BP, Monteiro MP, Sousa M, Oliveira PF, Alves MG (2018) Insights into leptin signaling and male reproductive health: the missing link between overweight and subfertility? Biochemical Journal. 475(22):3535-3560. DOI: 10.1042/BCJ20180631

Bernardino RL*, Carrageta DF*, Silva AM, Calamita G, Alves MG, Soveral G, Oliveira PF (2018) Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9. Cells. 7(10), 153. (DOI:10.3390/cells7100153)

Jarak I*, Almeida S*, Carvalho RA, Sousa M, Barros A, Alves MG, Oliveira PF (2018) Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (DOI: 10.1016/j.bbadis.2018.07.028)

Dias TR, Alves MG, Silva BM, Oliveira PF (2018) “Nutritional factors and male reproduction” In “Reference Module in Biomedical Sciences", Elsevier. (DOI:10.1016/B978-0-12-801238-3.64616-0).

Alves MG, Oliveira PF (2018) Sertoli Cells - Methods and Protocols, vol 1748. Methods in Molecular Biology, 1 edn. Humana Press. ISBN: 978-1-4939-7698-0

Bernardino RL, Alves MG, Oliveira PF (2018) Establishment of Primary Culture of Sertoli Cells. In: Alves MG, Oliveira PF (eds) Sertoli Cells - Methods and Protocols. Methods in Molecular Biology, vol 1748, 1 edn. Humana Press, pp 1-8. DOI:10.1007/978-1-4939-7698-0

Bernardino RL, Alves MG, Oliveira PF (2018) Evaluation of the Purity of Sertoli Cell Primary Cultures. In: Alves MG, Oliveira PF (eds) Sertoli Cells - Methods and Protocols. Methods in Molecular Biology, vol 1748, 1 edn. Humana Press, pp 9-16. DOI:10.1007/978-1-4939-7698-0

Crisóstomo L, Alves MG, Gorga A, Sousa M, Riera MF, Galardo MN, Meroni SB, Oliveira PF (2018) Molecular mechanisms and signalling pathways involved in the nutritional support of spermatogenesis by Sertoli cells. In: Alves MG, Oliveira PF (eds) Sertoli cells - Methods and Protocols. Methods in Molecular Biology, vol 1748, 1 edn. Humana Press, pp 129-155. DOI:10.1007/978-1-4939-7698-0

Jarak I, Oliveira PF, Rindone G, Carvalho RA, Galardo MN, Riera MF, Meroni SB, Alves MG (2018) Assessing Sertoli Cell Metabolic Activity. In: Alves MG, Oliveira PF (eds) Sertoli Cells - Methods and Protocols. Methods in Molecular Biology, vol 1748, 1 edn. Humana Press, pp 157-171. DOI:10.1007/978-1-4939-7698-0

Maggio A, Bernardino RL, Gena P, Alves MG, Oliveira PF, Calamita G (2018) A Stopped-Flow Light Scattering Methodology for Assessing the Osmotic Water Permeability of Whole Sertoli Cells. In: Alves MG, Oliveira PF (eds) Sertoli Cells - Methods and Protocols. Methods in Molecular Biology, vol 1748, 1 edn. Humana Press, pp 279-286. doi:10.1007/978-1-4939-7698-0

Carrageta DF, Dias TR, Alves MG, Oliveira PF, Monteiro MP, Silva BM (2018) Anti-obesity potential of natural methylxanthines. Journal of Functional Foods. 43:84-94. (DOI: 10.1016/j.jff.2018.02.001)

2017

Oliveira PF, Crisóstomo L, Sousa M, Monteiro MP, Macedo P, Raposo J, Alves MG (2017). O papel do Espermatozoide na Transmissão à Descendência do Risco para Diabetes Mellitus. [The Role of Sperm in the Transmission to the Offspring of the Risk for Diabetes Mellitus]. Revista Portuguesa de Diabetes. 12(4): 149-158.

Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T (2017) Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum Reprod Update. 24(1):86-105. (DOI: 10.1093/humupd/dmx033)

Cardoso AM, Alves MG, Sousa AC, Jarak I, Carvalho RA, Oliveira PF, Cavaco JE, Rato L (2017) The effects of the obesogen tributyltin on the metabolism of Sertoli cells cultured ex vivo. Archives of Toxicology. (DOI:10.1007/s00204-017-2091-x)

Crisóstomo L, Alves MG, Calamita G, Sousa M, Oliveira PF (2017) Glycerol and testicular activity: the good, the bad and the ugly. Molecular Human Reproduction. 23(9), 583-655. (DOI: 10.1093/molehr/gax049)

Alves MG, Oliveira PF (2017) Biochemistry of Andrology. Andrology: Current and Future Developments. Bentham Science Publishers, Sharjah, UAE. ISBN: 978-1-68108-501-2

González-Fernández L, Sánchez-Calabuig MJ, Alves MG, Oliveira PF. Macedo S, Gutiérrez-Adán A, Rocha A, Macías-García B. Expanded equine cumulus-oocyte complexes exhibit higher meiotic competence and lower glucose consumption than compact cumulus-oocyte complexes Reproduction, Fertility and Development. (DOI: 10.1071/RD16441)

Mathur PP, Alves MG, Oliveira PF (2017) Obesogens and sperm maturation. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. (in press)

Mathur PP, Rato L, Sousa AC, Oliveira PF, Alves MG (2017) Sperm Maturation as a Possible Target of Obesogens. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. (DOI: 10.2174/1871522217666170420092258)

Almeida SP, Rato L, Sousa M, Alves MG, Oliveira PF (2017) Fertility and sperm quality in the aging male. Current Pharmaceutical Design. 23(46): 1-1. (DOI:10.2174/1381612823666170503150313)

Dias TR, Alves MG, Silva J, Barros A, Sousa M, Casal S, Silva BM, Oliveira PF (2017) Implications of epigallocatechin-3-gallate in cultured human Sertoli cells glycolytic and oxidative profile. Toxicology In Vitro. 41:214-222. (DOI:10.1016/j.tiv.2017.03.006)

Oliveira PF, Sousa M, Silva BM, Monteiro MP, Alves MG (2017) Obesity, energy balance and spermatogenesis. Reproduction.153(6):R173-R185. (DOI: 10.1530/REP-17-0018)

Crisóstomo L, Sousa M, Alves MG, Oliveira PF F (2017) The Burden of Metabolic Diseases on Male Reproductive Health. Int J Diabetol Vasc Dis Res. 5(1e), 1-2.     (DOI:10.19070/2328-353X-1700012e)

Jesus TT, Oliveira PF, Sousa M, Cheng CY, Alves MG (2017) Mammalian target of rapamycin (mTOR): a central regulator of male fertility? Critical Reviews in Biochemistry and Molecular Biology. 52(3):235-253. (DOI: 10.1080/10409238.2017.1279120)

Oliveira PF, Cheng CY, Alves MG (2017) Emerging Role for Mammalian Target of Rapamycin in Male Fertility. Trends Endocrinology & Metabolism. 28(3):165-167. (DOI:10.1016/j.tem.2016.12.004)

Cardoso AM, Alves MG, Mathur PP, Oliveira PF, Cavaco JE, Rato L (2017) Obesogens and Male Fertility. Obesity Reviews. 18(1):109-125.(DOI:10.1111/obr.12469)

2016

Dias TR, Alves MG, Rato L, Casal S, Silva BM, Oliveira PF (2016) White tea intake prevents prediabetes-induced metabolic dysfunctions in testis and epididymis preserving sperm quality. J Nutr Biochem. 37:83-93. (DOI: 10.1016/j.jnutbio.2016.07.018)


Meneses MJ, Bernardino RL, Sá R, Silva J, Barros A, Sousa M, Silva BM, Oliveira PF, Alves MG (2016) Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis. Int J Biochem Cell Biol. 79:52-60. (DOI: 10.1016/j.biocel.2016.08.011)


Bernardino RL, Marinelli RA, Maggio A, Gena P, Cataldo I, Alves MG, Svelto M, Oliveira PF, Calamita G (2016) Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int J Mol Sci. 17(7): 1096. (DOI:10.3390/ijms17071096)


Martins AD, Sá R, Monteiro MP, Barros A, Carvalho RA, Silva BM, Oliveira, PF, Alves MG (2016). Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics. Mol. Cell. Endocrinol. 434:199-209. (DOI: 10.1016/j.mce.2016.07.008)


Bernardino RL, Alves MG, Silva J, Barros A, Ferraz L, Sousa M, Sá R, Oliveira PF (2016) Expression of estrogen receptorsalpha (ER-α), beta (ER-β) and G protein-coupled receptor 30 (GPR30) in testicular tissue of men with Klinefelter syndrome. Horm Metab Res. 48(06): 413-415. (DOI: 10.1055/s-0042-105151)


Rato L, Alves MG, Sousa M, Silva BM, Oliveira PF (2016) Sirtuins: novel players in male reproductive health. Curr. Med. Chem. 23(11):1084-99. (DOI:10.2174/0929867323666160229114248)


Bernardino RL, Costa AR, Martins AD, Silva J, Barros A, Sousa M, Sá R, Alves MG, Oliveira PF (2016) Estradiol modulates Na+ -dependent HCO3 - transporters altering intracellular pH and ion transport in human Sertoli cells: A role on male fertility? Biol Cell. 108(7):179-188. (DOI: 10.1111/boc.201500094)


Dias TR, Alves MG, Casal S, Silva BM, Oliveira PF (2016) Single and synergistic effect of major tea components caffeine, epigallocatechin-3-gallate and L-theanine in rat sperm viability. Food Funct. 7(3):1301-5. (DOI: 10.1039/C5FO01611H)


Alves MG, Martins AD, Jarak I, Barros A, Silva J, Sousa M, Oliveira PF (2016) Testicular lactate content is compromised in men with Klinefelter syndrome. Mol. Reprod. Dev. 83(3):208-216. (DOI: 10.1002/mrd.22608)


Jesus TT, Oliveira PF, Silva J, Barros A, Ferreira R, Sousa M, Cheng CY, Silva BM, Alves MG (2016) Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells. Fertil Steril. 105(3):825–833. (DOI: 10.1016/j.fertnstert.2015.11.032)


Alves MG, Jesus TT, Sousa M, Goldberg E, Silva BM, Oliveira PF (2016) Male fertility and obesity: are ghrelin, leptin and glucagon-like peptide-1 pharmacologically relevant? Curr. Pharm. Des. 22(7):782-791. (DOI: 10.2174/1381612822666151209151550)

2015

Rato L*, Meneses MJ*, Silva BM, Sousa M, Alves MG, Oliveira PF (2015) New insights on hormones and factors that modulate Sertoli cell metabolism. Histol Histopathol 31(5):499-513. (DOI: 10.14670/HH-11-717)


Rabaça A, Sousa M, Alves MG, Oliveira PF, Sá R (2015) Novel drug therapies for fertility preservation in men undergoing chemotherapy: clinical relevance of protector agents. Curr. Med. Chem. 22(29):3347-3369. (DOI: 10.2174/0929867322666150821094334)


Oliveira PF, Alves MG (2015) EDITORIAL: Cell Metabolism and Current Challenges in Drug Research. Curr. Pharm. Des. 21(25):1-2 (DOI: 10.2174/138161282125150818105309).


Ferreira C, Rabaça A, Sousa M, Oliveira PF, Alves MG, Sá R (2015) Impact of metformin on male reproduction. Curr. Pharm. Des. 21(25):1-13.(DOI: 10.2174/1381612821666150710150041)


Meneses MJ, Silva BM, Sousa M, Sá R, Oliveira PF, Alves MG (2015) Antidiabetic Drugs: mechanisms of action and potential outcomes on cellular metabolism. Curr. Pharm. Des. 21(25):1-15. (DOI: 10.2174/1381612821666150710145753)


Oliveira PF*, Tomás GD*, Dias TR, Martins AD, Rato L, Alves MG, Silva BM (2015) White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage. Reprod. Biomed. Online (DOI: 10.1016/j.rbmo.2015.06.021).


Vaz CV, Marques R, Alves MG, Oliveira PF, Cavaco JE, Maia CJ, Socorro S (2015) Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes. Journal of Cancer Research and Clinical Oncology. (DOI: 10.1007/s00432-015-1992-4).


Dias TR, Alves MG, Almeida SP, Silva J, Barros A, Sousa M, Silva BM, Silvestre SM, Oliveira PF (2015) Dehydroepiandrosterone and 7-oxo- dehydroepiandrosterone in male reproductive health: implications of differential regulation of human Sertoli cells metabolic profile. J. Steroid Biochem. Mol. Biol. 154:1-11 (doi:10.1016/j.jsbmb.2015.06.004).


Bernardino RL, Martins AD, Jesus TT, Sá R, Sousa M, Alves MG, Oliveira PF (2015) Estrogenic regulation of bicarbonate transporters from SLC4 family in rat Sertoli Cells. Molecular and Cellular Biochemistry. 408(1-2):47-54 (DOI:10.1007/s11010-015-2481-4).


Rato L, Alves MG, Duarte AI, Santos MS, Moreira PI, Cavaco JE, Oliveira PF (2015) Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells. Int J Biochem Cell Biol. 66:1-10 (DOI: 10.1016/j.biocel.2015.07.001)


Sá R, Sousa M, Oliveira PF, Alves MG. The use of spermatogonial stem cells in cancer-Induced Infertility. Int. J. Stem Cell. Res. Transplant. 03(2e) 1-2 (DOI:10.19070/2328-3548-150005e).


Martins AD, Moreira AC, Sá R, Monteiro MP, Sousa M, Carvalho RA, Silva BM, Oliveira PF, Alves MG. Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility? BBA-Mol Basis of Disease 1852(9): 1824-1832 (DOI:10.1016/j.bbadis.2015.06.005)


Alves MG, Martins AD, Moreira PI, Carvalho RA, Sousa M, Barros A, Silva J, Pinto S, Simões T, Oliveira PF. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients. Cell Tiss Res. (DOI:10.1007/s00441-015-2217-5)


Rocha CS, Rato L, Martins AD, Alves MG, Oliveira PF (2015) Melatonin and male reproductive health: relevance of darkness and antioxidant properties. Curr. Mol. Med. 15(4): 299-311. (DOI:10.2174/1566524015666150505155530)


Rato L, Alves MG, Dias TR, Cavaco JE, Oliveira PF (2015) Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Diabetic Rats Impairs Glycolytic Flux and Promotes Glycogen Synthesis. Journal of Diabetes Research. 2015 Article ID 973142 (DOI: 10.1155/2015/973142)


Meneses MJ, Sousa M, Alves MG, Oliveira PF (2015) The Antidiabetic Drug Metformin and Male Reproductive Function: An Overview. Int. J. Diab. Cardiov. Dis. Res. 3(1e): 1-2.


Reis MM, Moreira AC, Sousa M, Mathur PP, Oliveira PF, Alves MG (2015) Sertoli cell as a model in male reproductive toxicology – advantages and disadvantages. Journal of Applied Toxicology. 35(8):870-883 (DOI:10.1002/jat.3122)


Dias TR, Alves MG, Bernardino RL, Martins AD, Moreira AC, Silva J, Barros A, Sousa M, Silva BM, Oliveira PF (2015) Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile. Toxicology. 328:12-20 (DOI:10.1016/j.tox.2014.12.003)


Oliveira PF, Martins AD, Moreira AC, Cheng CY, Alves MG (2015) The Warburg effect revisited - lesson from the testis. Med. Res. Rev. 35(1):126-51 (DOI: 10.1002/med.21325)


Alves MG, Sá R, Jesus TT, Sousa M, Oliveira PF (2015) CFTR regulation of Aquaporin-mediated water transport: a target in male fertility. Curr. Drug Targ.16:1-14 (DOI: 10.2174/1573399811666150615144108)

2014

Dias TR, Alves MG, Oliveira PF, Silva BM (2014) Natural products as modulators of spermatogenesis: the search for a male contraceptive. Curr. Mol. Pharmacol. 7(2): 154-166 (DOI:10.2174/1874467208666150126155912)


Alves MG, Dias TR, Silva BM, Oliveira PF (2014) Metabolic cooperation in testis as a pharmacological target: from disease to contraception. Curr. Mol. Pharmacol. 7(2): 83-95 (DOI: 10.2174/1874467208666150126153830)


Alves MG, Oliveira PF (2014) EDITORIAL: Targeting Mammalian Spermatogenesis: a Matter of Support. Curr. Mol. Pharmacol. 7(2): 81-2 (DOI:10.2174/1874467208666150126160128)


Jesus TT, Bernardino RL, Martins AD, Sá R, Sousa M, Alves MG, Oliveira PF (2014) Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator. IUBMB Life 66(9): 639–644 (DOI 10.1002/iub.1312)


Rocha CS, Martins AD, Rato L, Silva BM, Oliveira PF, Alves MG (2014) Melatonin alters the glycolytic profile of Sertoli cells: implications for male fertility. Mol. Hum. Reprod. 20(11):1067-76 (DOI:10.1093/molehr/gau080)


Rato L, Alves MG, Cavaco JE, Oliveira PF (2014) High-energy diets: a threat for male fertility? Obesity Reviews. 15(12):996-1007 (DOI: 10.1111/obr.12226)


Dias TR, Alves MG, Silva BM, Oliveira PF (2014) Sperm glucose transport and metabolism in diabetic individuals. Mol. Cell. Endocrinol. 396(1-2): 37-45 (DOI: 10.1016/j.mce.2014.08.005)


Martins AD*, Bernardino RL*, Neuhaus-Oliveira A, Sousa M, Sá R, Alves MG, Oliveira PF (2014) Physiology of Na+/H+ Exchangers in the Male Reproductive Tract: Relevance for Male Fertility. Biol. Rep. 91(1):11. (DOI: 10.1095/​biolreprod.114.118331)


Jesus TT, Martins AD, Bernardino RL, Sá R, Sousa M, Alves MG, Oliveira PF (2014) Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells. Biochem. Biophys. Res. Com. 446(4): 1017–1021 (DOI: 10.1016/j.bbrc.2014.03.046)


Correia S, Alves MR,, Cavaco JE, Oliveira PF, Socorro S (2014) Estrogenic regulation of testicular expression of SCF and c-kit: implications in germ cell survival and male fertility. Fertility & Sterility.102(1):299-306 (DOI: 10.1016/j.fertnstert.2014.04.009)


Oliveira PF, Alves MG, Martins AD, Correia S, Bernardino RL, Silva J, Barros A, Sousa M, Cavaco JE, Socorro S. (2014) Expression pattern of G protein-coupled receptor 30 in human seminiferous tubular cells. Gen. Comp. Endoc. 201:16-20 (DOI: 10.1016/j.ygcen.2014.02.022)


Correia S, Alves MG, Oliveira PF, van Pelt A, Cavaco JE, Socorro S (2014) Transgenic overexpression of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways. Andrology. 2(2): 290-8. (DOI:10.1111/j.2047-2927.2014.00186.x)


Dias TR, Alves MG, Tomás GD, Socorro S, Silva BM, Oliveira PF (2014) White tea as a promising antioxidant media additive for sperm storage at room temperature: a comparative study with green tea. J. Agric. Food Chem. 62 (3): 608–617 (DOI:10.1021/jf4049462)


Rato L, Duarte AI, Tomás GD, Santos MS, Moreira PI, Socorro S, Cavaco JE, Alves MG, Oliveira PF (2014) Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. B.B.Acta-Bioenergetics. 1837(3):335–344 (DOI: 10.1016/j.bbabio.2013.12.008)


Martins AD, Alves MG, Bernardino RL, Dias TR, Silva BM, Oliveira PF (2014) Effect of white tea (Camellia sinensis (L.)) extract in the glycolytic profile of Sertoli cell. Eur. J. Nut. 53(6):1383-91(DOI: 10.1007/s00394-013-0640-5)


Alves MG*, Martins AD*, Vaz CV, Correia S, Moreira PI, Oliveira PF, Socorro S. (2014) Metformin and male reproduction: effects in Sertoli cell metabolism. British J. Pharm. 171(4): 1033–1042 (DOI:10.1111/bph.12522)

2013

Dias TR, Martins AD, Reis VP, Socorro S, Silva BM, Alves MG, Oliveira PF (2013) Glucose transport and metabolism in Sertoli cell: relevance for male fertility. Cur. Chem. Biol. 7(3):282-93. (DOI: 10.2174/2212796807999131128125510)


Bernardino RL, Martins AD, Socorro S, Alves MG, Oliveira PF (2013) Effect of pre-diabetes on membrane bicarbonate transporters in testis and epididymis. J. Memb. Biol. 246(12):877-83 (DOI:10.1007/s00232-013-9601-4)


Dias TR, Rato L, Martins AD, Simões AD, Jesus TT, Alves MG, Oliveira PF (2013) Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat Sertoli cells. ISRN Urology ID:970370. (DOI:10.1155/2013/970370)


Martins AD*, Alves MG*, Simões VL, Dias TD, Rato L, Moreira PI, Socorro S, Cavaco JE, Oliveira PF (2013) Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes. Cell Tissue Res. 354(3):861-8. (DOI:10.1007/s00441-013-1722-7)


Bernardino RL* Jesus TT*, Martins AD, Sousa M, Barros A, Cavaco JE, Socorro S, Alves MG, Oliveira PF (2013) Molecular basis of bicarbonate membrane transport in the male reproductive tract. Curr. Med. Chem. 20(32):4037-49. (DOI: 10.2174/15672050113109990200)


Correia S, Oliveira PF, Guerreiro PM, Lopes G, Alves MG, Canário AVM, Cavaco JE, Socorro S (2013) Sperm parameters and epididymis function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: a hidden role for Ca2+ in sperm maturation? Moll. Hum. Rep. 19(9):581-9. (DOI: 10.1093/molehr/gat030)


Alves MG, Oliveira PF. Diabetes Mellitus and male reproductive function: where we stand? Int. J. Diab. Cardiov. Dis. Res. 1(1): 1-3.


Alves MG, Neuhaus-Oliveira A, Moreira PI, Socorro S, Oliveira PF (2013) Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells. Reprod. Toxicol. 38:81-88. (DOI:10.1016/j.reprotox.2013.03.005)


Alves MG, Martins, AD, Socorro S, Cavaco JE, Oliveira PF (2013) Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function. Tissue Barriers. 1(2):1-12. (DOI:10.4161/tisb.23992)


Alves MG, Martins AD, Rato L, Moreira PI, Socorro S, Oliveira PF (2013) Molecular mechanisms beyond glucose transport in Diabetes-related male infertility. Bioch. Biophys. Acta. 1832(5): 626-35. (DOI:10.1016/j.bbadis.2013.01.011)


Rato L, Alves MG, Dias TR, Lopes G, Cavaco JE, Socorro S, Oliveira PF (2013) High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology 1(3): 495–504. (DOI: 10.1111/j.2047-2927.2013.00071.x)


Simões VL, Alves MG, Martins AD, Dias TD, Rato L, Socorro S, Oliveira PF (2013) Regulation of Apoptotic Signalling Pathways by 5α-dihydrotestosterone and 17β-estradiol in Immature Rat Sertoli Cells. J. Steroid Biochem. Mol. Biol. 135(1): 15-23. (DOI:10.1016/j.jsbmb.2012.11.019)


Alves MG, Rato L, Carvalho RA, Moreira PI, Socorro S, Oliveira PF (2013) Hormonal control of Sertoli cell metabolism regulates spermatogenesis. Cell. Mol. Life Sci. 70(5): 777-93. (DOI:10.1007/s00018-012-1079-1)

2012

Alves MG, Oliveira PF, Socorro S, Moreira PI (2012) Impact of diabetes in blood-testis and blood-brain barriers: resemblances and differences. Curr. Diabetes Rev. 8(6):401-412. (DOI: 10.2174/157339912803529896)


Alves MG, Socorro S, Silva J, Barros A, Sousa M, Cavaco JE, Oliveira PF (2012) In vitro cultured human Sertoli cells secrete high amounts of acetate that is stimulated by 17b-estradiol and suppressed by insulin deprivation. Bioch. Biophys. Acta. 1823(8):1389-1394. (DOI:10.1016/j.bbamcr.2012.06.002)


Laurentino, S., Correia, S., Cavaco, J.E., Oliveira, P.F., Sousa, M., Barros, A., Socorro, S. (2012) Regucalcin, a calcium-binding protein with a role in male reproduction? Molecular Human Reproduction. 18(4): 161-170. (DOI: 10.1093/molehr/gar075)


Rato L, Alves MG, Socorro S, Duarte IA, Cavaco JE, Oliveira PF (2012) Metabolic regulation is important for spermatogenesis. Nature Reviews Urology. 9(6):330-8. (DOI: 10.1038/nrurol.2012.77)


Oliveira PF, Alves MG, Rato L, Laurentino S, Silva J, Sá R, Barros A, Sousa M, Carvalho RA, Cavaco JE, Socorro S (2012) Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells. Bioch. Biophys. Acta. 1820(2): 84-89. (DOI:10.1016/j.bbagen.2011.11.006)


Rato, L., Alves, M.G., Socorro, S., Carvalho, R.A., Cavaco, J.E., Oliveira, P.F. (2012) Metabolic modulation induced by estradiol and DHT in immature rat. Sertoli cells cultured in vitro. Bioscience Reports. 32(1): 61-9. (DOI:10.1042/BSR20110030)

2011

2010

2009

* both authors contributed equally