Nature reviews urology paper is out!
Our recent publication in Nature Reviews Urology offers insights into the intricate interplay between high-fat diets, metabolic disorders, and their impact on testicular metabolism and spermatogenesis. Furthermore, we explore the intricate mechanisms through which metabolic disorders shape the epigenetic landscape of male gametes. This exploration unveils a potential avenue for understanding how phenotype traits could be transmitted across generations, shedding light on the broader implications of metabolic health beyond individual well-being. Have a look here!
David Carrageta has just defended his PhD Thesis!
David Carrageta recently completed his doctoral defense, presenting his thesis entitled: "Metabolic Modulation of Mitochondrial Uncoupling Proteins and Insulin on Human Spermatozoa and Sertoli Cells." Spanning 8 peer-reviewed papers, one of which was published in Nature Reviews Urology, David delves into the nuanced interplay of metabolic and hormonal factors influencing male fertility. Congratulations!
Mitochondrial quality in endothelial cells and oxidative stress in preeclampsia: new Paper out!
We're excited to announce the publication of our recent paper in the Vascular Pharmacology Journal, which delves into the application of real-time analyzers for assessing mitochondrial quality in endothelial cells and oxidative stress in preeclampsia. Our findings underscore the importance of conducting comprehensive investigations to shed light on the complexities of mitochondrial dynamics within the realm of this pregnancy-related disorder. Have a look here!
Metabolomics of Human Seminal Fluid paper published!
Our new paper published in Journal of Biological Regulators and Homeostatic Agents describes a propensity for increased levels of various amino acids in seminal fluid with advancing age. The paper provides compelling evidence of age exerting a discernible influence on the comprehensive seminal metabolome. Have a look here!
New Paper on Antioxidants Journal!
We are pleased to announce the publication of our paper titled "Impact of Chromium Picolinate on Leydig Cell Steroidogenesis and Antioxidant Balance Using an In Vitro Insulin Resistance Model." This study underscores the importance of caution when considering the use of chromium picolinate, even at lower doses. We uncovered mechanisms of the complex interplay between chromium picolinate and Leydig cell metabolism, as well as antioxidant defenses. We show potential benefits and risks associated with chromium picolinate use, particularly in the context of insulin resistance, in Leydig cells which are known for producing testosterone! Have a look here!
Research Summary
The overall goal of our research work is to deepen the knowledge on the basic processes involved in the hormonal control of gamete production and functionality, and thereby provide a scientific basis for improving both human reproductive health and fertility.
In our studies we make use of normal and pathological human tissues in order to learn about human reproduction and human pathologies that affect human reproductive health and fertility. Also, we perform studies using rodent model systems and cell-based systems as translational models for the study of the reproductive mechanisms.
In last years, the amount of data suggesting that environmental toxins/endocrine disruptors significantly affect human reproductive health has been increasing. Thus, the Sertoli Cell Biology up will also investigate how these agents affect fertility by means of studies in cell-based systems, animal models and/or human tissues.
Major Research Areas
• Effect of hormones on Sertoli cells ionic and water membrane transport mechanisms;
• Metabolic modulation of spermatogenesis in metabolism-related disorders/pathologies and mechanisms subjacent to the resultant subfertility and infertility;
• Role of sex steroid hormones in fertility and in the functioning of testicular and epididymal reproductive tissues;
• Mechanisms underlying the effect of endocrine disruptors and environmental toxins on human fertility.
