They could look at the chemical differences between hibernating snails and active snails to find longevity chemicals, “TIL Snails can sleep up to 3 years. They roll into their shells and bury themselves”
Things that benefit babies
After it is harmless for babies to enjoy recreational voluntary immersion in water and computers are able to perceive they enjoy swimming lessons they could find out what temperature of recreational swimming and bathing water babies most actively enjoy, photonic brain scanning, and facial recognition and audio interpreting software could get it figured out to .5 degrees C, also different babies might differ, and something like a hot water bottle or blanket that continuously varied it temperature to find the temperature where a baby would volunarily pull up the blanket over itslef or snuggle next to it would find each babies’ preferrred voluntary water immersion temperature
ultrasoft microfiber blankets and washcloths are already used for babies, I think babies might enjoy these and seek these out now, so is it possible to have disposable diaper linings that are made with the same material
There are baby massage classes, I do not know if babies enjoy massages, but a massage chair pad, attached to a computer could be placed at aprt of a crib, then if the baby voluntarily seeks out laying on it when a light turns on that says it will activate in 20 seconds babies could learn to seek it out if they liked it, and it would be harmless to test out as a baby gift to see if the baby liked the automatic massage
I saw an image online of a baby in an approximately 2.5 foot diameter 3 foot long inflatable mini pool that looked sort of like a tube, the baby’s head is supported with an inflatable pillow, after they figure out this is safe and harmless, they could find out if babies actively like it and it is neutral or good for cognitive development, they could also measure if it causes babies to cry less, sort of a very loose aqua swaddle, the babies being happier is a benefit, and the lack of crying is also beneficial
I have never seen waterproof electric blankets or electrically heated pool chairs at the side of a public or private swimming pool, I think these would make being out of the water more pleasant.
it is possible everytime you make a new krypton atom you make a material that emits white light as a plasma, so aiming protons at Br atoms might make Kr, or aiming alpha particles which have 2 neutrons at Se might make Kr, the thing is I read that proton capture is high energy, alhtough, at every universe where there actually is a proton capture than their is a new krypton atom, so however often it works, that MWI universe would always have one more krypton atom to emit white light, so can you just dip a uranium glass rod in Se, then at whichever MWI universe that entire alpha particle becomes a part of the Se nucleus making Kr
there are 3D printers that use UV light, “When the laser beam “touches” the resin tank, it cures the resin at that specific point. “ What if the resin contained a free radical releasing chemical that activated when UV illuminated it, then say 90 different levels of UV, or passes of UV light could produce 90 levels of stiffness. UV cured resins are well known
2019 cheapest car in China $2115 (forbes)
Drinking more water may cause greater longevity, That suggests that kidney gneticsl along with GDF15 could be longevity genetics
A more durable positive mood, they could find out if this genetically adjustable thing causes better mood all day, “The researchers found that participants with greater white-matter compactness tended to display a greater ability to sustain a positive mood during sleep deprivation.”
Variations in the human REST gene may be longevity genes, this gene effects could effect cognition so supercentenarians at the 99th percentile of g (like IQ) could be characterized as to what variety they have
Hi, I’m Treon and I take suggestions
I sense there is a synchronized pattern to things, and I was told there is a person who guides the people of earth. I think that person may read this, and I urge you to make suggestions.
longevity technology
Longevity technology:
the King’s Holly has lived 1.46 million days thus far, other trees have a lifespan of just 3650 days, ceasing to be alive even before a human reaches puberty; Finding longevity drugs based on the 400,000 percent different longevity difference between trees goes with doing HPLC, something better than electrophoresis like laser spectroscopy, electrophoresis or some other thing, to find all the chemicals, proteins, peptides, lipids, in the plants, as well as at human tissue, then finding those chemicals, proteins, peptides, lipids difference between the 1.46 million day longevity plant, the 3650 day plant, and the human;
I read humans share 60% of their genome with the banana, that suggests some plant genes, and plant gene products, and the amount of those chemical plant gene products, have most longevizing molecule versions that can be quantified as to longevity effects at yeast and mice;
finding longevity chemicals: the group of chemicals (and genes) at both the (3650 day tree and the human) that are different than the chemicals that the (kings holly and the human share) are places where the chemicals (and the genes) at the humans could improve and the king’s holly is the source of improvement;
At homologous genes an organisms that noticed it had the 3650 day plant version rather than the kings holly would notice an opportunity to have more longevizing chemicals endogenously produced
finding longevity chemicals: dosing yeast and mice with the chemical that the kings holly gene makes, that the human does not, noting the homologous but different gene, could find longevity drugs;
engineering mice and yeast to make that shared homologous kings holly gene then finding out if it longevizes them produces new longevity genes
This same approach works for finding longevizing chemicals between groups like million year lifespan endoliths comparison grouped with similar-to-endolith with different habitat organisms with 365 day lifespans, 214 year old whales, and whales with briefer lifespans, 400 year lifespan clams, and clams with annual lifespans, and supercentenarian humans with 18 year marmosets;
The genes and gene products (chemicals) that the 400 year clam shares with the annual clam are ignored when narrowing the list of chemicals and genes at the human to find 400 year clam genes with longevity effects;
Now, although the amount of the chemicals matters the same thing can be done with chemicals, proteins, peptides, and lipids at the bodies of the various trees and other organisms
If the chemical is the the 3650 day plant and the king’s holly, ignore it, if it is only at the king’s holly put it in a database;
This works better at varieties of the same species with widely varying lifespans, if there are any species that interbreed but have 2-4 times different longevity, then ignoring the chemicals they share, then making a database of the chemicals only at the long lived variety, then at humans finding if any of the database chamicals
There is a thing here though that kind of makes it improvable, for each 14 million chemicals the kings holly contains, and the 3650 plant overlaps 90% of them, that is still 1.4 million chemicals that might have longevity effects;
I think geneticists who write computer programs already know all about this, but if you have like 100 groups of related-organisms pairs (king’s holly 3650 day tree),(mouse, beaver), (214 year whale, less longevity whale), (human, primate with 1/5th human lifespan) with the group members as far apart as possible as to longevity, and then compare the amount the very different most long lived species converge towards each others gene versions, notably moving away from their species-similar organisim, then you find a possible math convergence around better versions of genes, or better versions of physiochemicals
The high longevity organisms at each of the 100 bowls of 2 or 3 longevity heterogenous organisms each
This technique can be used for other things like, 100 bowls of 2 or 3 mammals each, and the species similar mammals differ as much as possible on behavior, then you look at how the bowl leaders (of very different species) converge on various characteristics, these can be genes, fMRI of brain areas, even things like parenting styles; a human, or niftily, a deep learning AI can then make a list of trends
(Mathematically you would expect the beaver to be more like the mouse, but if the beaver is more like the whale, the human, and the King’s holly then there might be a longevity trend at that homologous gene, similarly you might expect a human to be more like a marmoset than a whale or the king’s holly, but at genes where the king’s holly is more similar that could suggest a “different chemical is better” trend, then noting the upper longevity organisms at each of the 100 bowls each with two or three species in them (mouse beaver, 214 year whale, less longevized whale) (longevized bat, less longevized bat) (human, primate with 1/5th human longevity)
The 100 bowls of three high distalness (long lived, otherwise) yet each bowl with similar species could be repeated at species that have particularly wide longevity ranges, perhaps birds as well; if this finds a longevity trend for a group of genes at very different birds, then the genes the different bowl gnes most share
also the 100 bowls thing of 2 or 3 organisms thing works with longevity chemicals as well, if 100 bowls find like 5000 circulatory chemicals shared at the long lived organisms out of each bowl, then those 5000 chemicals are compared to the chemicals in a human, any of the 100 bowl shared longevity chemicals the human does not (yet) have could be tested on yeast and mice and human tissue culture to find out if they are longevizing; this works with homologous genes as well, if you have 100 bowls of clams, birds, sharks, endoliths, plants, and other things, and the distal organisms in each bowl have and above-chance occurence of shared genes, then those could be longevity genes and a human would compare their genome to that shared at the 100 bowls of very different species; mathematically it would be possible to list in order the genes shared between bowls, and the longevity trend of just that group of bowl-set organisims, so it would be possible to find the likely most longevizing versions of the bowl-shared genes;
at endoliths, 100 bowls as a way to find new human longevity genes has nifty characteristics; endoliths can be bacteria, fungi, algae or lichen, very different species, but they all share lifespans longer than the entire span of human culture; first find briefer species that are most genetically similar to the endoliths, (3 century lichens) (24 hour bacteria) to put in the bowls, with each of the 100 bowls having an endolith; do HPLC on all the organisms chemicals, and sequence the genomes of the 200 or 300 organisms in the 100 bowls, then find where the endoliths converge towards each other, across widely differing species, and away from the other organisms at their bowl,
The chemicals (proteins, peptides, others) that subsets of endoliths produce that have varied amounts of convergence at different subsets of the 100 bowls can be tested as longevity cheimcals;
encouragingly, the 10,000 year lifespan creosote bush produces NDGA, which is also published as causing greater longevity at mice, so chemicals that 100 different endoliths converge on, at unexpected divergence from the other organisms in their similar species bowl, could be longevity drugs and chemicals;
similarly, the long lifespan but species heterogenity of endoliths (algae, bacteria, fungi) if there are any converged on homologous genes could actually suggests genetics of greater longevity at humans, that can be tested on mice, let’s say the endoliths all have mitochondrial DNA that causes mitochondrial uncoupling, then a human could look through a database of mammal genetics and genomes and find out if any mammals had uncoupled mitochondria, and the effect it had on that species being above the median, or high above the median on longevity; (I read that mitochondrial uncoupling actuallu doubles c elegans lifespan, it just seems possible to have a 100 bowl convergence be able to find it as well)
do the “are there any mammals like the converged endoliths’ homologous genes unusualness of form, and, how is it going for them?” thing automatically with computers, also, the technique can be used with any group of species like birds, or tortoises, or even bowls of plants, along with the kings holly there are many trees with multimillenia lifespans
when they do, that version of that mammal gene is unusually likely to be a longevity gene, and using yeast and mouse full lifespan to quantify its effects is beneficial and produces a longevity gene; notably though the gene sometimes makes a product like a protein, endolith converged, then found at mammal genes’ proteins could be screened as to longevity effect; I read that sme endoliths, after you put them in a comfy environment grow rapidly, and a kilogram of cultured endolith might provide enough converged-endolith-gene product to dose shrews, c elegans, yeast, and human tissue culture; (it is kind of nice with 100 bowls you get to skip screening a library, you just culture and gather material from of the species at one of the bowls that makes the converged on chemical, a mathematician would be able to suggest the optimal number of bowls, with endoliths perhaps it is 300 because, if there is convergence on some chemicals, rather than the numerics of screening a library you already have a source)
mathematically
I think a mathematican would be able to come up with an equation and a number to communicate divergence from species similars and convergence on high longevity;
Doing the 100 bowls thing on endoliths, or plants, finds chemicals that are common between high longevity organisms, that took some mathematically less predictable paths, to develop a shared trait, which produces chemicals and has genes that can be tested on other species to find out if the trend
There could be a 100 bowl convergence with three layers being outside a mathematically predicted form; three data points, i think i heard, can make a trend, and at 100 bowls of two or three organisms, the divergence from other organisms at the same bowl, and the convergence on specific chemicals and genes among the high longevity bowl organisms, suggests that if there is a third thing then the longevity trends will have greater predictive ablity for specific chemicals and genes (gene versions); one possible approach to making three data areas to make a trend from is to put a mid-longevity specied in each of the 100 bowls and find out if any of them are shared any of the chemicals (or gemes) that the highest longevity longevity animals comverge on
then the actual chemical and kind of cytochemical and tissue chemical network that the organisms with the greatest longevity at each bowl have, notably where this shared convergence on cytocommunication network form diverges from the similar species in the same bowl;
I read 60% of the human genome is shared with the banana, so if there is a human tissue chemical, made from a gene that is the same as that of a 3650 day tree, and there is an alternate version of that chemical and gene produced at the kings holly, then that is a human and tree shared chemical with what may be a much greater longevity version; yeast and mice could be utilized to find out if putting the king’s holly homologous gene at a mammal causes greater longevity;
senolytic dasatinib with quercetin treatment, 190 days compared with 140 days greater longevity from start of treatment, about 35% greater longevity, “20-month-old male mice treated with D+Q”, “For all dasatinib+quercetin (D+Q) treatments, D (5mg/kg, drug/body weight) and Q (50mg/kg) were administrated by oral gavage in 100-150 μL 10% PEG400. For treating 20-month-old mice, D+Q was delivered either once monthly or every 2 weeks, with essentially identical effects.once every 2 weeks (bi-weekly) for 4 months.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082705/
so that is 350 mg for a 70 kg human, 8 times, or 4 times at monthly 2.8 grams, mouse dose compensation factor changes that to 233 mg for all 8 doses.
The quercetin is 2.91 grams per dose, so 8 doses is 23.3 grams
At roayl jelly amking mice live midway between 24 and 26% longer 500 ppm at ad libitum food mixed with 9 parts trehalose was used, at mice that is 25 g a day human dose, or using mouse compendation factor that is 2.09 g/ad libitum feeding, the 50 ppm/ad libitum feeding was almost identicallly longevizing (112 weeks compared with 110 weeks high dose) and is 250 mg ad libitum feeding human dose, or 2.08 mg ad libitum feeding human dose with mouse compensation dose
That suggests enteric coated 20 grams of trehalose and royal jelly could be effective as an oral dose, coadministered with 2.08 grams royal jelly enteric capsule dose with food
That compares with 60 mg/kg of food at precis of paper, and at medium dose that is 60 mg/kg or 4.2 grams per 24 hours, or 420 mg per 24/hours at a 70 Kh human, without mouse comepensation factor the high dose is 25 gram ad libitum with trehalose and 2.09 grams with mouse compensation factor; note this does not function with high dose medium dose order or magnitude difference
The very large dose, based on mice eating 1/6 of their body mass a day, then calculating a dose on a human eating
Highest high mouse dose is 4.2 grams a day ad libitum with food, lowest high mouse dose is 350 mg, highest medium mouse dose is 420 mg ad libitum, lowest medium mouse dose is 42 mg
most of the mutants with long lifespan had mutations in the age1 gene [4]. This gene turned out to be the catalytic subunit of class-I phosphatidylinositol 3-kinase
(PI3K).
Sirtuins, epigenetics of sirutins, sirtuin supplements. it is possible endoliths like million year lifespan endoliths have novel sirtuin effecting chemicals
Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments such as the nucleus (SIRT1, -2, -6, -7), cytoplasm (SIRT1 and SIRT2) and the mitochondria (SIRT3, -4 and -5).
sitruins are deacetylases, SIRT6 is shown in previous studies to be a critical epigenetic regulator of glucose metabolism, it is possible that other things that upregulate or are actual deacetylases, including non epigenetic deacetylases could be longevity or healthspan drugs, screening a library of molecules that do about the same thing as SIRT6 could find a longevity hieghtening epigenetic drug that is more effective than SIRT6, sirt6 is linked to aging, temoleres and inflammation
SIRT like resveratrol-mimicking drugs such as SRT1720 could extend the lifespan of obese mice by 44%. However, “feeding chow infused with the highest dose of SRT1720 beginning at one year of age increased mean lifespan by 18%, and maximum lifespan by 5%, as compared to other short-lived obese, diabetic mice; however, treated animals still lived substantially shorter lives than normal-weight mice fed normal chow with no drug.[2] In a later study, SRT1720 increased mean lifespan of obese, diabetic mice by 21.7%, similar to the earlier study, but there was no effect on maximum lifespan in this study.[3] In normal-weight mice fed a standard rodent diet, SRT1720 increased mean lifespan by just 8.8%, and again had no effect on maximum lifespan.[3]”
43% greater maximumn lifespan from GDF15 is published “Female hNAG-1 mice (mice expressing hNAG-1/hGDF15) have significantly increased mean and median life spans in two transgenic lines. The effect is stronger in mice on high fat diet than on low fat diet. hNAG-1 mice display reduced body and adipose tissue weight, lowered serum IGF-1, insulin and glucose levels, improved insulin sensitivity, and increased oxygen utilization, oxidative metabolism and energy expenditure.
% change in avg or median lifespan
Female mean lifespan is up to 43% higher.”
The RNA microRNA 17 that increases longevity could be a longevity drug immediately with online ordering and enteric coated capsules or possibly snortable form, or both
microRNA 17
Mus musculus
Pro-Longevity
16%
Gdf15
growth differentiation factor 15
Mus musculus
Pro-Longevity
43%
A list of longevity increasing genes is at http://genomics.senescence.info/genes/search.php?search=&show=4&sort=1&organism=Mus+musculus&long_influence=pro&lifespan_effect=increase&search=&page=1Mir17 Growth/differentiation factor 15 (GDF15)
Nasal liposomes,
liposome formulations showed a mean diameter in the range of 175 nm to 219 nm with polydispersity index lower than 0.22, a lightly negative zeta potential and excellent encapsulation efficiency. Moreover, along with good mucoadhesive properties, multifunctional liposomes showed a markedly increase in tacrine permeability, which can be related to liposome fusion
with cellular membrane,
C-Pc liposomes were more effectively taken up by Neuro2a cells than free C-Pc and were biocompatible, maintaining the anti-oxidative properties of C-Pc. When optimal C-Pc liposomes were administered to middle cerebral artery occlusion (MCAO) rats 2 h after onset, infarct sizes were smaller and behavioral activities improved compared with the same metrics in free C-Pc-treated rats. Liposomal delivery still reduced infarct sizes and improved behavioral activity 6 h after onset, whereas free C-Pc did not.
Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug
Piperine is an antidepressant works better as a snortable liposome, “Antidepressant and cognitive effects of piperine-en- capsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 μg/day) were randomly as-signed to daily administer for 14 days to rats which were subjected to forced swimming, Morris water maze and spontaneous motor behavior tests. PL sig-nificantly exhibited anti-depression like activity and cognitive enhancing effects, in comparison to the con-trol groups after the first dose (p < 0.01) and the ef-fects could be maintained throughout the period of study. Quantitative analysis of the brain homogenates by HPLC indicated that piperine, delivered either orally or nasally, distributed to the hippocampus at a higher extent than the cortex and that the time to peak concentration of nasal PL was shorter than for the oral piperine. Intranasal PL was, thus, potential in delivery of piperine, at a low dose, to exert its an-tidepressant and cognitive enhancing activities.”
siRNA drugs can be administered with liposomes, “ntranasal delivery of the siRNA targeting Beclin1 significantly depleted the target protein expression levels in brain tissues with no evidence of toxicity.”
we developed a nose-to-brain delivery system combined with cell-penetrating peptide (CPP), Cell-Penetrating Peptides (CPPs), also known as protein transduction domains (PTDs), membrane translocating sequences (MTSs), and Trojan peptides are short peptides (≤40 amino acids), with the ability to gain access to the interior of almost any cell. They are highly cationic and usually rich in arginine and lysine amino acids. They have the exceptional property of carrying into the cells a wide variety of covalently and noncovalently conjugated cargoes such as proteins, oligonucleotides, and even 200 nm liposomes.
melatonin antidepressants, mood elevators exist, “Agomelatine is a structural analog of melatonin”, it is possible that like tyhe pineal peptide AEDG causes greater longevity molecular variations of these mood improving drus could be simulataneously longevizing and mood improving, “agomelatine. Agomelatine is a melatonergic agonist and a 5HT2c antagonist (i.e., it has a unique mechanism of action). The melatonergic function appears to improve sleep patterns, whereas the serotonergic antagonism results in the release of norepinephrine and dopamine.”
Previously described is finding the genetics of hving good dreams, I favor making the genetics of having good dreams part of the human germline, also, amount persons above the 99th percentile of longevity they could find those at the 99% of having actively good dreams and an absence of dreams the person would prefer to have skipped, this is a guide to finding the genetics of more beneficial sleep, it may even be possible that there are those at the 99th percentile of longevity who dream twice as much as others, dreaming good dreams twice as often is beneficial to humans and is beneficial to make a part of the human germline
g (like IQ) gene “klotho-enhanced mice performed better on a variety of learning and memory tests, regardless of age. In one test, the mice remembered the location of a hidden target in a maze better, which allowed them to find it twice as fast as control mice.”, Also, “overexpression of Klotho in mice might extend their average life span between 19% and 31% compared to normal mice.[8] In addition, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations.[15]”, “α-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and released into the circulation.”
“we report that GABA markedly increased circulating levels of Klotho”
people get their klotho levels increased as a side-effect of taking prescription forms of “activated” vitamin D (VDRAs) for chronic kidney disease (CKD). But there’s no reason to wait until you’re almost dying and need dialysis to start benefiting from this knowledge. Instead, this implies that taking something like 0.25 mcg/day of Calcitriol or 1 mcg/day of Paricalcitol (zemplar) right now for someone without the beneficial KL-VS variant of the KL gene might actually give a huge longevity and IQ boost. The intelligence boost is so large, that if this new study is right and the effects of klotho are at all acute, you should be able to measure it directly with something like quantified mind or perhaps even just raw introspection. Hopefully lots of researchers follows up on the most obvious implications of these two currently unconnected research findings and investigate activated vitamin D as a way to boost longevity and cognition
nonsentient robot pets could measure the amount, if any, children harm them, children harming 20th century organisms was linked to harm to the children themselves, software and companion robots could ask children to talk about these things, and suggest the children inform their parents about treating nonsentient robot pets certain ways, it is also possible there are psychometrics that ask about this now, in a different direction, it is possible that children that treat robotic pets well have happier than median relations with their parents
Babies might make other muscles on their face do the duchenne smile without moving thier lipds, if they find out that is an actual they could find things that are likely to make babies happy
I read about mice learning things, and comparing different chemicals and drugs on learning, It is possible to make new all positive reinforcement operant conditioning learning behavior standardized measurements with only positive reinforcers; One possibility is lever press food of two flavors, one flavor enhanced, at mice this could be enhanced with standard concentration sweetness and also standard concentration attractive scent (notably there is an opportunity to distinguish between an attractive food scent, and a different scent attractive to mice, possible a component of the naturally occuring scent of other mice), also a nonfood reward could measure completely different cognitive componets and brain functionality as the nonfood areas of the brain are responding, colored lights and a euphoric, rapid action at humans stimulus, DMSO droplet with cocaine at nude mice could be a 30 second to 3 minute availableized reward at nude mice, or even be active if a mouses nose touches a DMSO-cocaine soaked sponge, It is even possible that a maze learning test could be used to find out how accurately sought a pathway, as well as how many moments to get to a “cocaine lounge” where cocaine might be administered as variable reinforcement at doses and frequency, or , amount, or as an experimental prequel to the actual thing being tested, that are absent interference with the actual drug or other experimental variable being tested.
Noting that nondrugged, not experimental variable exposed mice, previously trained at finding a cocaine lounge, as well as experimental variable: drugged mice trained at finding a cocaine lounge, goes with the ability to find the probability and numeric methods numbers on mice that: on starting a cocaine lounge maze that has either a cocaine lounge alerting light or scent, or an initiating flavor food pellet that communicates “this is a cocaine longe maze” then the different variable at experiment drug’s effects could be numerically treated. The avidity and capability of prequel to experiment cocaine lounge mice which are untreated with the test drug (or other new variable) are numerically characterizeable with the measurment of the avidity and capability measured amounts from similar prequel cocaine lounge experienced mice.
DMSO nose touch pads could work with rewards other than cocaine;
Although nitrous oxide could be a euphoric stimulus for solving a puzzle, it seems like although fun this ius only slightly motivating at humans and perhaps actively nonmemorable
Beneficial thing: beauty and other things that are all positive feeling, perception, and thought producing one actual felt, thought, or isness effect, rather than combined effect, “mixed bag”, or a kind of sequence of qualia notes, with some of the qualia notes eliciting anything other than positive feeling, even neutralness.
I view a woman, her curves and face what I have read is called line are enjoyable to view, the vehicle she got out of elicits concern, that qualia of concern, even though it is beneficial for other humans for me to actualize utilitarian benefit to those that elicit concern, (perhaps a person says “say, you can get a new car for less if you put 1/2 a car value in a high yield, fund with some quantifiable risk, then get a new car every 3 or 7 years when you double your money, at the very harmless risk of driving your current vehicle twice as long, the URL is gettwicethecartwiceasfast.com”)
making everything more optimal for everybody, the non-combined positive effect could be specifically created and specifically beneficial. So a planner could have a woman, and when I view her, her curves and face, and she also radiates well being and radiates opportunity increase to the viewer that the viewer feels as positive, is a noncombined all positive experieince; The technology is to find and make things that are all positive experience for humans, that is persons, that is people, to experience and have them at the environment such that they occupy the mental and physical niches that previously the combined, but generally positive, or mixed bag, but generally positive,[stimuli, objects, emotion-eliciters, and experienceable processes] previously occupied, thinking gooder thoughts and doing gooder things could be facilitated with accumulations and experiencables of gooder things at the environment; this could even replace the “but” qualifier with the “and” or the “That makes me think of” spontaneous actual mental occurence as well as its use in speech. So having a positive experience viewing the face curves and line of a woman, “and she looks like she would get along with (person)”, as well as her beauty, noting face and curves and line spontaneously, causes qualia that feel like: connectionizing to Abunchofgoodthings thatmustbeinfocusatthistheplaceandmoment, or the feel of a really optimal lightbulb somewhere illuminating things Also, idea occur pre-words, like really, a person might spontaneously think “girl flavored lightbulb is room composition rebalancing; semiconductors could make every item at an architectural space optimized; the way experiencing this girl optimizes everything, at a noticebaly visual way” and then the person viewing the girl instantly knows a new kind of light bulb that can exist.
with or without verbal internal narrative thinking, causes a qualia )or also perhaps, optionally mental verbal narrative)
Complete novelty and AI generated images, sensations, finding-of-new-online content, as well as a library if things, like images, sounds, virtual reality things. actual haptic actual things, as well as screening a library of images, sounds, and actual things, and actual orchestrated occurences (a compliment on an actual thing an actual person actually does)
Money source that is likely to cause more rapid technological development while also raising energy efficiency of vehicles, reducing accidents, and providing “new thing is enjoyable” feelings:
Timing and planning of getting a new car for less if you put 1/2 a car value in a high yield, fund with some quantifiable risk, then get a new car every 3 or 7 years when you double your money, at the very harmless risk of driving your current vehicle twice as long, the URL is gettwicethecartwiceasfast.com”; also, the companies that advertise their get a new car faster shares funds could also advertise longevity medicine and technology funds; novel to me is that as 156% or higher combined different greater longevity drugs and technologies could be utilized for
reninded of newtorks, while being reminded of math, while being reminded of equations that
iterators, alorithmicizors, automata, that have highest amount of beneficial distributions of effect produced; if these are distinguishable beween algorithm hosters, then some have diffrerntiazable product state space amountnessess, math of analog, digital,
is there a mathable area or milieu where if you are not yet having observed it, but have a finite possibility of observing it, that it could exist, even though you do not know what it is yet;
longevity technology: alternate day fasting is published as having the same cardiovascular benefits as calorie restriction https://www.inverse.com/article/58820-how-is-alternate-day-fasting-different-from-caloric-restriction , with 36 hour fasts and 16 hour eating periods causing the benefit; This creates the possibility of a number of longevity drugs that are fun to use, possibly nootropic, similar to, or even existing few AMU drugs, and can even be produced with gene therapy: I like the feeling of being on phenylethylamine for the first 11-14 hours, and it makes it so skipping meals is easy, and I think I have skipped 24 hours of food on it unintentionally.
Longevity causing volunary svelteness drug that increases creativity, productivity, and likely intelligence: An AM time release dose of phenylethylamine that
lasts 14-15 hours until 1 hour before sleep, then 7.5-8 hours of spontaneous sleep, with the previous phenylethylamine time release dose having another AM, until sleep, all day pulsatile dose at waking dose could preclude any daytime hunger for both days, and be taken once every 24 hours, the person would then eat a lunch dinner or breakfast every 36 hours: the drug could be fine chronological time release as well as molecularly fine tuned to optimize well being, nootropic, successtropic; phenylethylamine is a euphoric drug that increases my creativity, and I perceive my intelligenece, This molecule, as well as FDA preapproved ADD/ADHD/Narcolespy drugs could also be tested; at phenylethylamine, molecule variations like phenylbutylamine, phenylpropylamine, as well as partially saturated cycles that range between phenyl group and cyclohexane group could be tested. (mice? circadian?)
Deprenyl is a MAO-B inhibitor that causes greater longevity, and makes people more cheerful, taken with phenylethylamine it causes phenylethylamine to last 200-300 minutes longer, notably though, stacked pulsatile 20-40 minute activity periods are possible with phenylethylamine when takeing it without an MAO-B inhibitor:
deprenyl/other MAO-B inhibitor with PEA: 9 hours effortless calorie restriction
PEA only 2 hours, effortless calorie restriction,
PEA only 2 hours, effortless calorie restriction,
Magnesium threonate: Calming nootropic, also a longevizing calming is a possible nootropic
Other molecules that might be fun enough so that people voluntarily take a longevity wellness svelteness drug: halogenated, ethynylized CART peptides or better than CART stimulant peptides that also have a circadian rhythm release effector (peptide moiety? or, a drug release polymer could get 100 times as diffusive at a .5 degree circadian body warmth shift, like liquid crystal polymers that turn color, or there could be an electret polymer drug that when it changes .05 decrees C or less causes it to furl or unfurl to have different receptor activating charge and changes biological activity a few orders of magnitude (note, depot injection at cool part of body makes it so the part of the body with the widest degrees C spread, ear tips are a possibility) The circardian mechanisms at either the CART peptide (or better) depot or the molecule the depot actually contains causes the alternate day caloric restricotion longevity, wellness, fun,
“Better for you than coffee” is a way to communicate the benefits of the fun and productivity part of this longevity wellness, heart disease, cancer preventing drug.
that cause the alternate day fasting calorie restriction like longevity, wellness, body mass enhancement effects could be made into a depot injection or depot implant that lasts over 200 years
depot drugs with multicentury benefits could also have multi hundred times mg/dose effectiveness (nanogram or picogram) effectiveness with drug transport channel optimization, tissue or cyte type localization, Cytes that have just 40, 300, 5000 of some particular molecular transport channel protein would have hundreds of times greater tissue localization at drugs tyhat have an effect even when absorbed at each cyte’s cytoplasm; alternatively drugs with 40, 300, or 5000 times the activity at efflux cytomembrane although absorbed at the same velocity might be effluxed 5000 times faster causing much less actual active drug molecule residence moments at the cytoplasm.
gene therapy that ups beneficial metabolizing enzymes at the actual cutoplasm, detoxifying things
nucleur membrane efflux, opposite effluxors, also hyperffluxing tRNA, mRNA could have faster transcription
Phytosomes are a word for liposomes around plant products, it is possible some variety of liposome, like phosphatidylserine as compared with phosphatidylcholine or a different length of alkane the phosphatidyl group has some localization, that variation in brain (and body) localization from plant based lecithin extracts as a delicious coffee replacement drink could keep the part people like and get rid of the agitation that people find objectionable to where I saw writing with line art comics about. Also, the people that make it can do more than screening a libary of 20 or 40 GRAS phophatidyl amino acid variants of human volunteers, it could look to phosphatidyl liposome making molecules with high lipophilicity, high hydrophilicity, or high at both liophilicities; It is even possible that without caffeine agitation the doses could be higher so people get 200-300 mg of up and prosociality and an absence of agitation; I could mention it to LEF.org, they actually already have a beverage product; Happier, kinder, tremorless, possibly even alert but sleepable 5 hour energy drink, and also organic version.
phosphatidyl 10HDA, screen a library to find a new longevity drug; while this complements liposomes as a technology, it is actually just a fluid that could be taken as a supplement, drug, or as a food additive.
Does piperine attached to the actual molecule cause it to have more blood brain barrier permeation amount, or is is just a coadministration (seperate drug) effect? Drug localization with piperine distal or branched to the localization moeity and the drug moeity could cause specific neuron active drugs to have only membrane permeation effects at those particular neurons, causing a heightened dose/mg multiplier, absence of nonfocal tissue permeability effects,
crispr gene drive with a molecular cytotransprt peptide transport peptide transport peptide on it first; does it have 100 to 1000 times greater dose/mg effect from preferential transport to the transfected cytes, that could cause 100 to 1000 times greater vector ability at transfection; also, this could heighten localization at paticular phenotypes as well
network effects at neurons, more ot it than this, but connections per node, causes variation in distribution of node products, so a stable producte high amplitude first deviation highly beneficial nod product could have its number of noides as an average, adjusted with genetics as well as gene therapy or even drugs to change the distribution histogram math of the network math, a netowrk where a genetic modification or existing gene variation causes such things as the not just the median number of interconnected neuron neighbors, but the distribution of neightbor interconnections so High-Medium-High is comparable with medium high medium and others at neurons, also the different effects of different neuron interconnectivity distribution networks is benefically technologyizable, Noting these networks at just one kind of neuron’s kind of beneficial effect getting the amplifaction, compare BDNF
also, network math effects from just 1,2,3, and 30^3 could have much high amplituded of effects than just changing amount of neurptransmitters, amount of circulating nuerotransmitter effecting drug, and quantification of amount of recptors, this makes neural cyte type localization of network connectivity modifiers have higher bandwidth of discernable effects and higher actusal magnitude (height) of possible effect of modifying neurotransmitters or even neurotransmitter drugs;
During 2019 it is my perception that svelte persons had more spontaneous physical activity than non-svelte persons, so along with the wellness, longevity, healthspan, aesthetic, social factor enhancement heightening from being a svelte person is it also possible the the greater spontaneous movement and willingness to move cause people to raise their children with more actual active acts, and even a greater quantity of things like hugs and active play, svelteness at parents likely benefits their children.
a researcher found the most similar protein to royalactin in vertebrates/mammals, and called it regina; to make longevity proteins ultraaffordable, could the same homologous gene sequence matching used to find Regina be used to find royalactin-like proteins as transcribable protein making things at plant genomes? These could then be grown, purified, and tested as to their longevity effects on mice both as orally ingested proteins and enteric coated high availability, non-digested proteins; Plant sources of 10HDA could also be found this way. Oral ingestion of royal jelly is published at causing mice to live 25 (27%) longer, so there is a possiblility that even digested homologous sequence to royalactin genes’ product could have a longevity effect even with digestion, this would make genetically engineering it into human foods, animal foods, and perhaps all plants with gene drive to benefit humans and other species.
Does royalactin or 10HDA benefit plants in any way, if they do this could be simultaneously beneficial to the plants and the humans to genetically engineer the production of higher amounts of the
network optimization based on math could be used with many worlds interpretion of physics to make whiter branch universes, notably branch universe groupings, and a possibility of something gooder than a round matrice where any of the combinatorial additives as well as the component portions, which might be particular MWI universes, the content of those universes that create new branches, and, if and where technologically function, those MWI universes that communicate with other MWI universes, the combinatorial, or higher
thinking, feeling, and being white causes more MWI universes from a heightened amount of electron, matter, and possibly modellable effect on things physically at greater than 1 micrometer distance from the thinking feeling organism like the most benevolent human, person, a member of a group of people that is a homo sapiens, notably all living beings with presence of being, isness, that I perceive some people may be called or related to sentience, having white being, moments of thought and feeling, and actualized white action and behavior and even building cause more MWI universe branches to be generated than from any human thinking or feeling that is not as benevolent, beneficial, simultaneouslu utilitarian
a thing that benefits children: If, or when, children can choose their own parents, including social companion robots,
are there any cytotransport proteins or membrane channels in the oral or nasal mucosa? If there is transport of some peptide, protein, or chemical then Snorting or swishing a thing in your mouth could have 10,100,1000 times the delivered chemical, drug, or gene therapy dose making it possible to skip the GI tract, also I have noticed that some things cause a kind of mouth pucker, suggesting hydrostatic balance can be modified with harmless things people put in their mouth, anbesol penetrates 3-4mm of gum tissue in 14 minutes or so, so if some similar molecule works on cheek epithelia at 2 mm in less than 7 minutes (1 mm a minute) that could be a transported chemical; DMSO or an absorption/transport enhanced version of DMSO is likely to function: it is possible things like diethylsulfoxide or dipropylsulfoxide, or dibranchedlakanesulfoxide could be oil blobs that spill around less, adhere to appliques, while still causing preferential transport of beneficial drugs and chemicals; if the duoalkanesulfoxide has a long enough alkane it is even possible putting a halogen on it or an ethynyl group could cause some kind of multihundred times increase in transport or physiological activity, so the halogenated ethynylized duoalkanesulfoxide could be chemically linked, possibly with an enzymatically degradeable linker to an active pharmaceutical drug;
Half to 1/4 cent Gene therapy technology: 3 mm paper circles, perhaps $400 for 12 million or 12 billion of them, each has a flavor attached to a protein, branched protein possible, so the longer it is at saliva the flavor changes through 11 different flavors, at each flavor 19/20ths of the proteins attached to the flavor chemical are at a certain shape, or have had their branches modified to be a certain shape, the paper circle progresses through all 11 flavors and the person can take the paper circle out of their moth at any time, defining and making into a gene therapy effect actualization program specifer, the characteristics of the amino acid, which could be a branched amino acid, then after being rinsed in fresh water, which removes the saliva, the amino acid sequence tells the bacteria that will arise from the bacteria at the paper circle which CRISPR/cas9 sequences to activate at the bacteria, out of the full library of 11 variants at the bacteria; the bacteria have molecular transport channels engineered to preferentially transport the flavor and color that the human, that is person, that is member of a group of people, that is homo sapiens, has preferred, At the bacteria 19/20 (the amino acid fraction) of the first generation of bacteria are gene therapy activated modified to be the persons preference, at the next bacterial generation, 19/20th of the other 1/20th are modified to be the gene therapy preference, so then 1/400th of the bacteria are different, then at the third generation of bacteria, something near 1/9000th of the bacteria have a gene therapy form different than the person’s flavor and color preference, notably I read bacteria reproduce every 20 minutes, with optimization, and a nutrient environment with things like mitosis stimulants, this could imaginably be 4-7 minutes, so a 16 minute span of bacterial doubling would cuase 8999 out of each 9000 transfection bacteria to be the preferred gene therapy version; Notably the person can then place the paper dot on their skin, and then have the paper dot’s bacteria do the gene therapy on the person using their skin, I have read about sugar micro projection drug delivery and immunization projections, these could cause the bacteria, possibly notably the bacteria growing on them, to be delivered deeper to the dermis absent a sensation to the utilizer, also the projections could have a tissue permeabablizing fluid on them like a phospholipid (liposomes are about four times more effective at some kinds of tissue transport, and a kind of liposome called a phytosome is hundreds of times more effective at transport), it is remotely possible that an anticoagulant, something like DMSO, dermatocyte transport channel activating chemicals like peptides or proteins on the outside of the liposome that cause active transport, possibly transcytosis, of the bacteria through the dermis to living gene therapy functional dermatocytes, capillary epithelia, and the circulatory system to occur (although the bacteria could emit CRISPR/cas9 containing single or double stranded DNA or RNA viruses continuously while physically thriving), so that is 300 (sugar divot makers) times 1000 (transport channel proteins or peptides) times 2 (anticoagulants) times four (DMSO) times 14 (Na PCA causes moist contact surface fourteen times longer) times 2 (the paper circle has anticoagulants to make the contact area particularly aqueous and transmissive, once the bacteria are there they, at non gene drive areas of the bacterial genome, produce minute amounts of harmless coagulants at each successful mitosis to cause 1/3-1/14 the fluid flow near the growing bacterial colony, reducing immune response to the bacteria 1/3 to 1/14, then 4 times from harmless to tissue, bacterial hyperproduction of enzymes that if applied separately to the skin, would like youthification chemical peels, actually cause enhanced skin appearance, these cause four times the nutrients to be produced from an appearance beneficial, harmless to regrowing tissue turning of dermatocytes into bacterial food; four times from tissue seeking bacteria; It is possible that the bacteria, like proteus, could actively swim towards the dermatocytes and seek spaces between cytes to permeate and seek depth to multiply. Compared with bacteria on the skin, these bacteria at this system (300 times 1000 times 2 times 14 times 2 times 3 times 4, 201 million times more effective at doing gene therapy; it could be possible to multiply this 201 million with three more powers of two to make the bacteria 1.6 billion times more gene drive vector effective. The combination of 9600 DPI printed circuit electroporation (7 times), DMSO (8 times), and immunotransparent gene therapy bacteria (4 times) causes the 201 million number to go to about 45 billion multiples greater colonization ability than bacteria just placed on the skin; inkjet printed Electroporation geometries and circuits: I think at inkjet printing of 9600 DPI or higher that it is possible to print electrode metals, dry yet hygroscopic electrolytes and conduction pathways, simple circuits could be printed like dozens or hundreds of arrays of dozens of Mg Ga Zn Ag metal dot patterns at 9600 DPI, and hundreds or even thousands of separate, sequentially activated instances, that are linked together to make higher voltages, and to put those higher voltages near other areas of 9600 DPI printed material, like bacteria at gel, membrane transport chemicals (proteins, peptides, chemicals), possibly even single or double stranded DNA or RNA viruses, or even capsid viruses to cause 7 times higher migration through and permeability at tissue; I read online that electroporation with DMSO after that caused 8 times greater transfection, so DMSO at the paper circle with the elecroporation could have another 8 times multiplier; Another thing that could heighten gene therapy transmissivity at a 3 mm paper circle: The bacteria as well as single or double stranded DNA or RNA viruses with the CRISPR/cas9 could be engineered to be immunotransparent (immunoneutral surface), with the body’s first immune response at 20-40 days from first appearing at the circulatory system;
Notably, it could be possible to do a bacterial gene therapy, or all synthesized gene gene therapy with just sequenced, or mass produced at organisms, but outside of organism nucleotide chemicals, micro sugar probe inoculators, 9600 DPI printed electroporation paper circuits on a 3 mm circle, DMSO (or a more optimal chemical), flavor and color user preferrable enzyme actions on chemicals that determine the actual gene therapy installed, also the membrane transport proteins, peptides, or chemicals linked to the actual CRISPR/cas9 genes to bring the gene therapy to the cytes, also, it is possible that nuclear envelope transport/focus peptides I read about could be placed at CRISPR/cas9 assemblages to cause a power of two or even orders of magnitude greater genetic insertion, successful translation, transcription, and propagation from nuclear transport; One reference says 70% electroporation transfection efficiency when also treated with DMSO, https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016%2816%2936452-8.pdf
If it is possible to inkjet print, at manufacturing quantities, a 7 to 14 layer of ink/electricity source/reagent/bacteria (or other CRISPR/cas9 source) at a 8.5 times 11 piece of paper for $11, then 71.9 3 mm circles times 93.1 circles is 6696 3 mm gene therapy flavor and color user experience voluntary gene therapy dose applications; notably this is 608 apllications per $1, or .164 cents per dose, or about 6 doses per cent.
It is also possible soaking the paper in 3 of the ingredients, and just printing the electroporation circuits, biochemicals, DMSO (or more effective duoalkane sulphoxide), actual gene sequences, bacteria, single or doube stranded DNA or RNA viruses, the polymer layer that causes deliquescent (autogooey) liquid layer to be at the dermis side, and the immunocolorizing material that lets people know when the gene therapy is successful;
How to make the sugar based cytomaterial inserting probes: These sugar linear probe things are published as functional at immunization, so they can reach through the dermis to the circulatory system to do immunoactivities, a few technologies to make these could be a mm or less deep sugar 9600 DPI print homogenous surface, then have lasers engrave the sugar layer to make various amounts (millions? thousands?) of probe/insertion items per 3 mm paper circle; another technology to make the sugar probes/insertion things, is to just spray coat the paper with microparticulate sugar probe insertion shapes, and measure the actual effectiveness of the actual percentage of right side up, high angle sugar probes that spontaneously occur. It is possible that a technology that causes an order of magnitude greater transfection efficiency could make a 40-70% right side up sugar probe gene therapy transfection paper circle have the transfection effectiveness of a 99th percentile right side up sugar probe array; One possibility for another power of two or even order of magnitude of transfection efficiency is to have the sugar probes have materials in them to be electrically conductive (calcium ions are published as having utility at gene transfer), this could bring the electroporation voltage effect to the dermatocytes at depth, likely near the endothelial capillaries (where I perceive sugar probe immunzation geometry sizes might reach), another possibility if the sugar probes are laser engraved is to have them have linear channels on the sides that cause the transfection material to flow to the tip of the sugar probe, also I read about superhydrophilic microsurfaces, they favor liquid coatings, and look sort of like troughs; bulk mass production of liquid transport geometries at sugar probes: putting linear grooves at the sugar probes might also work at mass produced sugar probes, with the nonspecific application angle as a spray, perhaps the sugar probes when manufactured and previous to placement at the paper circles, could be sprayed on one side with a surface tension reducing agent or some other thing that causes liquids to like flowing a particular direction;
The bacteria would also produce beneficial wellness, healthspan, longevity youthification chemicals even at the non CRISPR/cas9 part of the bacterial genome; At mice and humans, the measured longevity wellness and healthspan of the bacteria would be beneficial even preceding the highly beneficial voluntary gene therapy part;
As the bacteria’s proteolytic nutrient producing enzymes are also the enzymes that make youthification chemical peels functional administration can be at any body location, puffiness of a less than 1 cm area (1 ml tissue transfected/ bacterial colonized continuous output CRISPR/cas9 gene therapy vector) could be an engineering standard; the bellybutton could be the least noticeable, and perhaps 90th percentile or higher of being least probed with fingers, the bellybutton could be among the 90th percentile at user adherence, is completely sensationless, does not cause visible change, has laser addressibility if persons, that is humans, that is members of groups of people, that is homo sapiens would like to laser modify the gene therapy process, notably some varieties of gene therapy are published that are responsive to light, so the 1/6th of 1 cent gene therapy technology is affordable and has further reach, a laser adjustable version is also possible.
Also, to verify the gene therapy has been installed, the bacteria could produce a chemical that causes an aesthetically pleasant color change at the paper circle (similar to color antibody diagnostics), the paper circle could change the visual pattern of the aesthetically pleasing color when the gene therapy had progressed beyond the bacterial vector and was being produced at the user, person, human, or application’s genome
Think of a way or cause for people to distribute something that is less than 1/10,000 of a $
Longevity technology: a new kind of autophagy could be linked to longevity, healthspan, and wellness, if it is functional: Noting the idea that cytoplasm might have nonorganelle enzymes floating around, catalyzing things, possibly even comminuting or nonactivating some cytochemicals: These enzymes, outside the lysosome remind me of autophagy, autophagy is linked to cytorefreshment, longevity, and wellness, it could be that the genetics of having more cytoplasm enzymes outside of organelles do something like an alternate version of autophagy, refreshing and recycling physiostructures and chemicals, so looking at a variety of mammals, notably things like multicentury lifespan whales, beavers, naked mole rats, bats, tortoises, and parrots and 400 year lifespan or longer clams, kings holly, and creosote (reminded of mitochondrial apoptosis) any cytoplasm enzymes, notably proteolytic or membraneolytic, outside of organelles (like lysosome) could be quantified at mice as to longevity wellness and healthspan effects, and if beneficial made into gene therapy, drugs, or germline enhancement or optimization at humans;
Noting autophagy is linked to longevity, wellness and healthspan, and I might have read that AMPK heightens autophagy, it could be possible to engineer larger amounts of autophagy from 1) cytoterminating chemicals, proteins or peptides as drugs (possibly kind of senolytic like), also as periodically automatically activated gene therapy; an accumulation of physiologically beneficial peptides, like AEDG heightening with each sleep occurence, could, when they accumulate to a particular amount, cause the gene therapy modified tissue to produce a new circulating amount of the new autophagy chemical, causing fresh autophagy and renewal at the living human; these likely would benefit from localization to create beneficial differences in concentration and action at different cytes and tissues;
Along with heightening cytoplasmic autophagy like effect enzymes, periodic production of autophagy as algorithmically activated with a completely beneficial physiochemical that accumulates (epithalon, thymosin, likely a variety of things, possibly even beneficially heightened circulating omega 3 DHA from accumulation of DHA from endogenous production), there is also periodic, quantitatively measured as beneficial to longevity, wellness, and healthspan, triggering of mitochondria to zap cytes, causing leukocytes to absorb them.
New to me autophagy longevity technologies: Another possibility is a periodic genetic activation of the production of a non-autoimmune activating production of antigens at the surface of cytes, possibly those at the 40th percentile or less of cyte and tissue youthfulness, where the percentile is an experimentally quantified causative function at wellness and healthspan; this could possibly be quantified with mRNA transcript production’s deviation from a beneficial range (reminds me of engineering tolerance, the 2nd standard deviation at the non-preferred side of the distribution) Periodic activation of the beneficial new form of autophagy could be linked to the accumulation of a physiologically beneficial chemical (epithalon, thymosin, omega 3 DHA);
New to me autophagy with high cytotype localization technology: I perceive I read about where two different receptor proteins, when both activated, caused a cyte to be exposed to a chemotherapy drug, causing fewer well cytes to be dosed with the chemotherapy; Responding to things like: At cytes that are at less than 30th percentile of wellness, longevity and healthspan heightening physiology, the translation/transcription protein generators receive instructions to make notably larger amounts of one normal type, but comparatively tissue and cyte unusual chemical, protein, or peptide transport channel, perhaps something that occurs less than 1/400th of a cytes’ external receptors or transport channels, and at perhaps less than 1 per 200 different cytotypes and tissues, it then becomes 1/20th to 1/40th of the proportion of the cytes external transport channels and receptors enumerated amount, (twenty or ten times as populous as previously), and then an transport channel optimized autophagy causing protein, peptide, or genetic effect causes autophagy at that cyte; The concentration of the autophagy causer is 40 times greater at the 30th percentile nonwell cytes than at well, wellness, longevity and healthspan functionally active cytes; Technologically it seems possible that autophagy could be tuned to to be activated when the transport protein heightened autophagy causer is above 30 times that at an unaffected cyte;
As a another supporting technology, it is possible a protein, peptide, or peptide effluxing transporter could be part of membrane accumulating cytotransport duo; at a well, longevity, wellness, and healthspan support heightening, functional cyte the transport and efflux of a particular protein, peptide or chemical from the duo, which could be spontaneously occuring at a nonmodified organism or human, would be about the same amount, they would omit accumulating the transported protein, peptide, or chemical at the cytoplasm; that would cause any autophagy activating chemicals, proteins, peptides, or gene products, to pass through well cytes above the 30th percentile causing a minimal amount at the cytoplasm of the 30th percentile of higher cyte; When the measure of the longevity functionality, wellness, and healthspan of an unwell cyte occurred it would cause the unwell cyte to make large numbers of the harmless chemical cytotransport structure, causing it to be 40 times more prevalent at the unwell cyte; natural endogenous circulation of things that that particular transport protein transports, would reach 40 times the usual amount, causing a gene at the cyte to make an autophagy causing molecule endogenous to they cyte; another technology is to have the autophagy causing protein, peptide, or chemical that is linked to a 40 times usual amount transport protein moeity for hieghtened transport to the 1th to 30th percentile cytes, be produced at a different area of the body, perhaps from just a few gram, or even one gram area of gene therapy;
Technologies that could discern longevity, wellness, healthspan contributive and supportive cytes above the 20th percentile: mRNA, possibly gene therapy that caused presence of nonbeneficial mRNA, cytochemicals, proteins, or peptides, to cause
Normalization algorithms create higher and higher longevity, wellness, and healthspan physiochemistry, it is possible that technologies that cause the least (0- 20th percentile) longevity, wellness, and healthspan supporting cytes to be quantified as they relate to the to other cytes at the body, to be as a relation to all the cytes at the body continuously or periodically, would cause double digit % increase in baseline longevity, wellness, and healthspan annually, this could physiochemically contribute to a percentage of longevity increase, and noting the continuous improvement of 20% more longevity, wellness, and healthspan cytes annually is likely larger than an annual accumulation of nonwell cytes, that like actuarial escape velocity, things move towards wellness, longevity, and healthspan faster than they wear out; The effect of multiple 20th percentile autophagy events causes the after autophagy organism to be accumulate towards what would previously have been 90th percentile or higher cyte function as to longevity, wellness, and healthspan physiochemistry; that similarity to actuarial escape velocity, which I have also read is called longevity escape velocity, is alogrithmically related to making each iteration of cytes that support longevity, wellness, and healthspan as the new computational basis for the percentiles. A technology I read about, which might be called gene switches, makes things like AND and OR as well as other logic forms out of simultaneous gene modification effects; The technological algorithm that supports the heightening of each iteration of 20th percentile or less’ autophagy to be based on a new foundation could be based on things like: gene therapy at the entire body causes harmless unique peptides or proteins to be produced, which then utilize mechanisms that are usual to move to the exterior cytomembrane of the cyte they are produced at, This labels each cyte with a non immunoreactive cytosurface diagnostic of what it is doing and making, it is possible the diagnostic proteins that make their way to the cytosurface are actually beneficial, noting the cyte is still alive, or also possibly beneficial to neighbor cytes, the (0-20th percentile) producers of just the completely beneficial interleukins, possibly some onconeutral neutral growth protein like BDNF, or if immunotransparency and absence of immunoreaction of any kind is beneficial, perhaps slight variations on water transport proteins (aquaporins), where variations from the usual protein amino acid sequence would let diagnostic things that cause the 40 times greater amount of transport channels to cause beneficial autophagy find and have effects on cytes at less than the 20th percentile; Gene logic could also just have quantifiable things effect logic, to cause the production of mRNA that makes the 40 times higher amount of autophagy transport channels at the cytomembrane; it is also possible that gene logic can just directly make autophagy functional effects directly at any cyte where the gene logic notes 0-20th percentile longevity, wellness, and helthspan physiochemistry;
also possibly periodic wellness chemical accumulation (epithalon, thymosin, omega 3 DHA) that activates the production of “make transport channels” at the unwell cytes;
Also possible is the unwell 20th perctile making 40 times more transport channels, and then a human, person, a member of a group of people, that is a homo sapiens, takes a drug to cause the autophagy, much more beneficial is an automated, periodic, automatic process, which could technologically be based around a one gram or less area of gene therapy that emits things that diagnose, modify and cause autophagy at cytes at the (0-20th percentile) of longevity, wellness, and healthspan, noting the continuously new distribution’s new foundation; Notably though, there is also the technology of a multihundred year longevity depot injection that just causes autophagy anywhere a group of antibodies (I perceive I read about fewer AMU versions of antibodies) note some unusual distribution of surface characteristics (proteins), also I think I read about antibodies that can glom to receptors to make them stay active, go less active, or just be neutrally at the cyte, this might function at cytotransport channels as well, possibly antibodies glomming unwell cytes
Gene logic
possible that without antibodies, this would cause autophagy at virus inected cytes from their being at 30th percentile or less of wellness quantifications, the incidental antiviral effect could be beneficial to both the person, and even possibly reduce the amount of viruses circulating at the population. The 30th percentile of wellness autophagy technology could be a nonimmunosystem new to me approach that kind of incidentally removes virus infected, oncocyte, and even possibly, fiberous nonutility tissue, which might be replaced with weller cytes. It is kind of like a new to me, multipurpose, new (30th percentile quantified effect at any nonoptimality) kind of senolytic, with different criteria than various intracyte deleterious products like interleukins;
the versionbs of these technologies or others that create longevity, wellness, and healthspan beneficial new versions of autophagyor germline enhancement or optimization
Longevity technology: an antiglycation mechanism could be found at some animals then tested at mice anfd humans to see if it increased longevity, healthspan, and wellness, also, gene variations at humans like SNPs could be correlated with wellness and absence of or reduced glycation at humans, and then causality measured with mouse studies to find beneficial genes for human gene enhancement or also optimization; notably though I perceive plants also do the nonpreferred glycation of proteins, so anything at plants that is produced at cytes that reduces glycation could be tested at the mammalian genome to find out if it benefits longevity, wellness, and healthspan, notably the 40,000 year old King’s holly, the 10,000 year old creosote bush, and the 4k year old conifer might each have a different plant genetics of antiglycation that benefits their longevity that could be tested at mice and humans.
When a person gets gene therapy, they might like having a way to utilize their previous genome at some or even all their cytes: backup with gene therapy: crispr/cas9 appends the new genome to the previous genome, puts a start codon (or start codon group) imaginably at a sticks-out circly pouf on the nucleotide double lane topology, the body ignores the first, previous, genome, which might even have some stop codons crispr/cas9ed into it at easily recognized locations (sort of like restriction enzymes say “thing here” perhaps stop codons could be placed at the previous genome anytime a CCCCC occured, so if editing it out it would be near errorless to utilize the previous genome, if the utilizer felt like it.
I have not read about any siRNA longevity molecules, It is possible these are possible, and that siRNA that heighten AMPK and decrease mTOR (or another 60% greater mouse longevity mTOR drug, that works on just mTOR1 rather than mTOR1 and mTOR2), siRNA might be even better at reaching the CNS through the blood brain barrier as their AMU is less than some other nucleotides
I perveive there might be a million or more actin lanes per cyte, at 70 trillion cytes, that could be like a math iteration structure with a really large number of math areas to model, algorithmize, and generate, something like interpretations about things as compared with, and possibly as a beneficial resource to the brain and CNS; Like what if the 70 trillion cytes with actin paths simulated various effects of various possible things, and communicated the modelling results with a one thing one meaning language;
um, I perceive how DNA per cyte has lots more data space, it is just that actin paths also have lots of functional movement, geometry, spatial accessibility…
It likely already exists, but is there a CRISPR/cas9 automatic gene sequence linker? I perceive different lengths of DNA have different easiness of transfection like 3/4 a decade ago (2011), but the perception I have of of CRISPR/cas9 is that they have figured out how to make. transfer, and activate things with out about 20,000 genes with simultaneous high velocity, high accuracy, and high editing sucess (transfection); complementing that, perhaps at a variety of sizes, could be something that is effective at attaching one sequence to another, at a functional place and physical form, (imaginably, histonated, less histonated, a loopy part available because of a mitosis, translation as well as transcription event, meiosis, or some new thing that is new to me)
so, one approach is to find the easiest histones on earth; some mammal has histones with really long, super editable, physical like-new preservationess above other mammalian histones, really available DNA; completely making a synthetic sequence of that, then making if even more genetic engineering friendly, then placing it at a variety of mammals, likely including humans, could benefit DNA transcript fidelity, DNA preservation, translation velocity at organisms, like humans, as well as heightening beneficial, functional, engineering friendly genetic editing, modification and genetic engineering;
Also, besides unlooping things, and actually I have no idea what they do, but I perceive DNA is unusually accessible during translation, mitosis, meiosis, and possibly some kind of “make this” thing that something at the nucleus says, like imaginably, if something says “make ribosomes” perhaps hundreds of ribosome making DNA locations get sequentially availabilized rather than just like one, over and over again; so, it seems possible they have tried loading up a well human cyte with a numerous quantity of things to translate at DNA, so they could unspool a bunch of DNA, efficiently, and edit it;
Along with making like a big list of DNA access producing translation instructions, they might have some amazing thing like a DNA translation smoothified new to me histone that makes DNA completely available to editing (like crispr cas9 or more advanced) while being a place to have a lot of DNA stay linear, functional, well, effective, and immediately ok to utilize without repairs; the smoothified histone could even be nifty at some ethynilization methylization optionalizing, gene modification now able to be unaffected from methylization and ethynilization molecular topology effect; a smoothified histone like an inspection and upgrade access area of an airplane;
Is there an artificial intelligence thing where if people, or AIs share the technology the sharers accumulate greater prosperity; it is possible AI APIs
Longevity technology: finding human gene variants that predict responsiveness to different longevity drugs would be beneficial. Rapamycin and a rapalog each are published at 60% longevity increase, my perception is that that math functions describe a medianized response, so noting half of all persons are above median, perhaps a greater than 60% rapamycin response could be predicted, and a gene therapy or a coadministered gene product upregulating drug might be able to cause a 99th percentile rapamycin response.
Squiggles developed with AI deep learning have been published that cause primate brains to produce more activity than views of faces and nature, it is possible that new squiggles developed with deep learning AI could cause greater amounts of response than the beauty responding areas of the human brain, and that when humans view these squiggles people describe them as attractive, appealing, and beautiful. I am not aware of research on deep AI generated squiggles that are beauty experieince activating above that of nature and human faces and form that are three dimesnional or that vary gradually. Among many beneficial uses of these squiggles could be decorating architecture, decorating energy producing utility plants (among them wind, photovoltaic, nuclear, chemical), hairstyles, and notably anything with above median utility and during the year 2019 less than median aesthetic impression; trash dumpsters, parking facilities, some public transit, medical appliances, anything on a list of survey generated “could look better” things at public and private spaces.
It is possible that things that are already aesthetically beneficial like plants, landscapes, nature, aesthetically appealing humans, could have versions and variations of deep AI developed beauty squiggles, and that actual spaces could be quantified as to their beauty response as well as images duplicated. Also, automated mechanisms or also robots that clean and arrange dwelling spaces could arrange items that humans view and utilize to be simultaneously highly available and, with beauty squiggle technology, arranged at ways that cause higher subjective well being increasing beauty response than the person doing their own arranging. People could of course do their own arranging, they might more often appreciate deep AI guided arrangeements of things.
Aesthetically mild to beneficial things like computer interfaces and printed text, could generate a beauty response while being combined with other deep AI developed squiggles that simultaneously increase comprehension and retention to create beautiful and cognitively enhanced interfaces and text; I favor a computer interface and text interface that causes heightened sense of well being (the psychometric: subjective well being increase from experiencing beauty), the “nice space” architecture effect, the “startlingly gorgeous” art object response, and even the human reponse to human female beauty response at persons with any form of human sex chromosomes occuring at 98% or more of people;
There are no top of page results on a search of “chemical vapor deposition metallurgy” so these are some chemical vapor deposition metallurgy technologies. I read that 3 nanometer silicon features are produced at integrated circuit technology, noting that arrays of atoms can have much more than an anisotropy or two at (25 atoms per feature, one to 20something billion features per IC, ) a trillion deposited atoms, that suggests that rather than a 3 nanometer feature size a 1 nanometer atom group feature size could be produced, and that the dots could be customizably amorphous, crystalline, variations of crystalline or other forms.
rather than an integrated circuit phototemplate it is possible a UV laser could produce a regular array of dots or shapes at a photoresist with diffraction grating technology, switching between a few, or even a few hundred different atom location preferentialization areas could produce a wide range of material characteristics;
thoughts on the size of chemical vapor deposition metallurgy part sizes: MEMs technology could also be a guide, with thickest chemical vapor deposition metallurgy being some higher of power of two than the 24 hour thickest MEMs object production cycle, it could be higher, if manufacturing time equivalence is considered (a company orders parts for delivery every month, giving as much as 1 month photolithography growth or possibly MEMs thickness build up), if something like UV lasers with a diffraction grating can be adapted to modify the shape of a growing single crystal of tungsten, like those used at some airplane turbines, then that could be a metallurgical chemical vapor deposition object size guide (although perhaps not, as I think they might pull those out of a melt)
Other ways to make features of less than 1 nanometer: It is possible that one photon, even at one frequency, from a laser, could have variable absorption likeliness based on grouping and entangling (linking) photon spins. At New Scientist magazine I read about a quantum camera, where a beam of quantum entangled photons met a figurine, and the other group of photons the first photons were entangled (linked) with made an imnage on a camera chip, the shape of the figurine caused the figurine to be imaged on the chip from varied photon energy availability based on photon spin, there was an absence of an optical path between figurine and camera chip; Notably, large numbers (thousands) of photons have been quantum entangled together, and it is possible that adjusting the spin effects on each of the 1000 photons separately could produce 1000 gradations of either absorbability at the figurine or electrical charge effect at the imaging chip. The same technology with 16 quantum entangled photons making the chemical vapor deposition metallurgy optical guide could have 256 levels of possible charge variation and atom attraction/deposition/enarrayment, or also likeliness of causing a deposition; so although the physics seems iffy to me, there might be a locational effect beyond light wavelength, or at least an automatic 16 bit halftone effect, possibly per each 1 nanometer sized dot, possible.
I read about the kind of thing that might be a new metallurgical effect at chemical vapor deposition metallurgy, https://news.wisc.edu/bending-the-rules-a-revolutionary-new-way-for-metals-to-be-malleable/ a new kind of bendability based on amorphous shear bands,
Isotope effect technology that benefits integrated circuit fabrication technologies, I read that, “The whole wafer is then subjected to UV radiation, allowing the pattern mask to be transferred to the organic layer. The radiation either strengthens the photoresist or weakens it. The uncovered oxide on the exposed photoresist is removed using Hydrochloric acid. The remaining photoresist is removed using hot Sulphuric acid and the resultant is an oxide pattern on the substrate, which is used as a mask.” Noting HCl and H2SO4 are used at making integrated circuits, it is possible that making HCl that has only 34 amu CL or 35 AMU Cl, or just one of what I think might be 8 different stable Sulfur isotopes could change etch characteristics and perhaps one of these 9 variations has quantifiable benefit to making better integrated circuits and MEMs things; I do not know why deuterated, slower moving etchants would be more functional, although they might be similar to etching at a lower temperature.
a CVD gas that is like 1/100 some other gas, where the gas molecule is big (10 or 20 timess more AMU), does thee heterogenous collision regime cause different renyolds numbers swirliness to occur? Then you could get different rates of sponatanbeous mixing, and possibly nudge up to reaction velocity at a distribution, or a different shape of lump at a normal distribution to have a different proprotion of mor elikely to crystallize cooler lumps as a fraction of the whole; that means gas blends could produce different rates of crystallization from something like chemical vapor deposition at semiconductor process technology
similar I have heard nucleation sites cause crystals to grow, and that more nucleation sites can cause cause crystals to grow more rapidly while still being crystalline
do different isotopes make for different nucleation site energies (Hg UV light emissions spectra difference, so might be different
nucleation sites: things like SiCl4 gas might notice more nucleation sites if some of the things thiey were crystallizing on had more nucleation sites, nucleation sites that might be compatible with semiconductor process technology CVD coulkd be like 1/1000 part SICl3F or SiCl2F2 CVD gases, when these were right at the wafer surfaces they might make siCl4 right next to them extra interested in crystallization while having harmless SI deposition if the SiCl3F reacts with the wafer itself.
Customized plasmonics (electron hole pair location and geometry engineering) could cause more, better, optimized production of nucleation sites at a growing semiconductor (or MEMS) wafer; beaming things at the wafer that cause plasmonics geometries at its surface could do this, beneath or side of wafer solitons, dissipative solitons,
mass quantum spin observations (like planar regions of entire spin polarized thing resolvability resolution) could, like the quantum camera described at New scientist, cause entire surfaces to have a micropatterned electric charge on them, that micropatterened electric charge could be used to produce nucleation sites to physically patternize crystal growth at the planar semiconductor wafer surface, as well as create the possibility of customized engineered plasmonic geometries right at the wafer surface which could be used to cause more rapid deposition of CVD gas constituents, rapidifying semiconductor process manufacturing, noting that doubling this velocity could cause the number of semiconductors a fab produces to double, heightening productivity, profitability, and the variety of different kinds of semiconductors that can be produced; As an actual technology, something like a 300 mm wafer with a light source, where the light source, is divided into two quantum entangled (linked) beams, or actually planes, basically planar arrays of light, and one of the beams, that is planar arrays of light, travels to a quantum camera light sensor array that is numerous powers of two higher resolution that the feature size of the features being made at the wafer having its semiconductor features produced, like a (billion times a billion feature, or 10 billion feature times 10 billion feature ) quintillion (10^18) or larger number of light sensors per 300 mm wafer chip, then whenever one of the photons meets the surface of the wafer its electrical charge modifying ability depends on if the photon at the quintillion feature chip has had its spin determined with light detection events, Note there is something that is new to me at the engineering processes, the photon meeting the feature could be doing numerous different things: it could be making a nucleation site, causing growth, it could be causing some kind of mathematically meaningful spin variant effect, fractional charge, which then effects atomic bond formation (crystal growth), it could be causing a moment of reduced reactivity, causing, relatively, other things near it to be growing higher faster, The mathematically meaningful fractional charge variation, Note that just one photon doing something this could be an accumulative number of spin-effect pulses build up to one entire atoms change (crystal deposition, crystal subratacted) amount, (what if it was a few hundred photon spin observation moments to do each atom attaching to a crystal, and a over a quadrillion (LED laser ordinary) light pulses per second but perhaps not two atoms amount, so actual amounts of atom gowth at the crystal growth is directable; the adjustable growth rate for finer, greater repeatability of features of action at this makes engineerable feature fineness, homogeneity of crystallization)Noting the entire wafer at the semiconductor fab being manufactured: then if the kind of custom made, quintillion feature (billion feature rows, billion feature columns) photonic spin detector chip is doing this quantum camera thing at a couple of orders of magnitude higher physical resolution that than the quadrillion (or higher) actual feature chip being produced then that is a new to me semiconductor feature producing wafer technology; feature size, fineness, repeatability, possibly composition (sort of liked doped-ness where beyond the stoichiometry of the chemical vapor deposition gas causing the doping variety of the layer or feature the adjustability of photon spin at several powers of two higher spatial resolution, quadrillions of times per second from the quantum camera causes something like crystal atom at atom growth with a halftone-dot like predictability of dopant spatial geometry, homegenity, or possibly even a new kind of feature, depth (like say you put a 40% halftone screen dopant layer of atoms on a 20% dopant layer, and you might even be able to use the spin effects to change dopant element ratio like 40:Ge:40:Ga:10N:10:P to 90Ga:10:N at a cumulative layer thickness, even at a particular line width)
it could also be a quintillion feature photon spin modifying photon sensing chip, doing the quantum camera thing at semiconductor process manufacture production of semiconductors doing quadrillions of photon cycles of spin observation responses per second could actually write features at a quintillion feature chip
Notably though, can you actually aim light at a semiconductor wafer while making it? Well, the photolithography template is a light aiming thing, and there is likely published material on using a lasers to do things on chip features right on the wafer while it is being manufactured, so this brings up, can you illuminate a wafer, then fill the chamber with CVD gas, then have the gas react with the wafers surface based ont he light you just illuminated it with; some spin polarized gases stay spin polarized for 15 minutes so that is supportive, At some wavelengths, the pure crystals of wafers could be treated as lenses for lasers that shine through to the wafer treatment surface from underneath, at some geometries of shining a laser, or a planar array of spin polarized light (a thing that is different than a banch of parallel lasers, or also different, but possibly producible with a diffration grating and a laser making an array of points), having the light illuminate the wafer obliquely from the side could be done at less than a millimeter above the surface, minimizing beamspread from the CVD gas having a refractive index; also possible is that noting CVD gas has a refractive index, at some applications, different concentrations of CVD gas could be used that have different refractive indexes, so if crystal growth velocity is adjustable with photonic and spin photonic, and reynolds number gas swirl technology that vary surface charge as well as actual CVD gas concentration then it might be possible to grow semiconductors just as well even if CVD gas concentration varies across an order of magnitude, giving an order of magnitude greater transparency and light spatial, intensity, coherence, and other attribute nondivergence
I do not know, but it is possible that if you spin polarize something its emissions and absorption spectra are different so if you shine two lights at a material, one that changes the spin of the atoms at the material, and the other that gives the material a photoelectric effect charge boost that then causes chemical reactivity, that you can change the kinds of things the material will react with, when it will react, if that is
It might be possible to do a raster or parallel version of quantum camera spin customization of spatial things at making semiconductors as well, where a mere billion feature quantum camera spin detector and actualizing photosensor chip, used repeatedly as scanned, at a 10 billion times ten billion feature 300 mm wafer with the features being built on it is used, possibly with photonic spin observations being made quintillions of times a second (noting picosecond lasers exist, and some kind of picohertz elecronics exist to drive them)
Making quantum cameras with 100 picometer resolution or finer causes finer feature size at the actual size of the semiconductor device the fab is making to experience spatial spin modifications (quantum camera), geometry, and possibly plasmonic feature stimulation at the semiconductor crystal surface five powers of two eentsier than than the features being produced, or optimally, makes creating eentsier feature sizes possible; I read 3 nanometer semiconductor size feature are being scaled up, 1 nannometers is this possible now noting 1 nanometer technology could be used if you are willing to make a few hundred and keep some, or possibly keep a couple at 300 picometer technology; you could make 1 nanometer or 300 picometer feature sized photodetectors at a 300 nm wafer, with three or 8 times the resolution of a 3nm process wafer, or imaginably, something like very custom 100 picometer feature UV laser process produced chip, where you make a few thousand and get one you can use, but its ability to resolve and instantiate photon spin polarization and other observation things (3, 800, 400, 200, 100 picometer) five powers of two tinier than a 3 nanometer process chip causes even greater tininess, feature finess, size, shape making, and repeatability at the observed integrated circuit being made at the fab; not only are tinier features possible, but faster production of the 3 nanometer size feature semicodnuctors is also possible heightening fab productivity
There are UV emitting quantum dots, it is imaginable that these, perhaps just from being made an order of magnitude different sized, at 300 picometer rather than 2.5 nanometer, could make higher wavelength radiation
It is possible that at light there is some kind of thing where if you know (measure or make) some things then you know, or tend to not know others. It is possible that if you know something like spin (up/down), or polarization (linear/angle, circular, other) of light you might know more, or possibly less, about its wavelength. It might be possible to make a light emitter for semiconductor manufacturing (wavelenth feature size new technology) where perhaps you do not actually know where between UV and visible its wavelength is, but as a result of observing some other thing like spin, polarization, evanescence presence or distance, source geometry/simultaneity thing (kind of like double slits possibly having a wavelength that is definably determinably at some range because if the two slits are wider apart than some number of wavelengths then the ~~~~ per nanometer are some particular size range, so if you use slits of some kind to look at white light photons you know nothing about, with some spacing of slit and see it then you are “certain” knowledge of-producing, at least some energy at an energy regime of a certain ~~~~~ size. Notably, at something like the quantum camera, observing it at the light sensor might make it so energy of just that ~~~~ size has an actual amount of ergs at the other thing the quantum entangled (linked) photons are shining on; so instead of light going on a chip (camera sensor at New sceintist, or described here as the actual wafer surface of a semiconductor being made) and a figurine, you put light on a chip and a thing (rather than a figurine) from made up of a bunch of slits, then you look at what comes from the bunch of slits, and that means that at the chip (camera or the thing being made at a fab) photons of that ~~~~ size and ergs are, at some quantity, being deposited; noting picosecond lasers exist, a person doing things to the surface of semiconductor, like one being manufactured, could do this slits make energy ~~~~~ size and ergs thing trillions of times per second, causing accumulative change from the energy change at a crystal being cumulatively deposited or even etched; the nifty thing is that you have illuminated the wafer you are making with wide spectrum white illumination, and just immanentizing the part that is far enough at the far UV to make features that are tinier than 2019 light size and photolithography feature size, building up something billions or trillions of times per second, at what, side-observationally (without knowing the actual wavelength), have to be, really high frequency waves causes semiconductor features to be built up or etched out
Using a quintillion optical sensor wafer to cause spins to be defined, or undefined at another surface, notably the surface of semiconductor manufacturing process wafer being created, makes it so that the photons that reach the wafer being made are more chemically active, more electrically active, kept from causing charge, so making their neighbors show up up more, or, notably are at a frequency blend which contains, at least, if not more, but at least, the frequency the quantum camera spin topology plane making thing can respond to, then these things can be used to make features at semiconductors, kind of like doing AND, OR, NOT, and possibly XOR of light doing thing at a feature sized spot on a quadrillion feature sized wafer being observed into varied surface charge topology with a quintiliion feature sized photodetecting quantum camera
Supersaturation causes more crystals to grow with less chronological moments, is there a feature size, fineness, regularity, and repeatability preserving way to supersaturate (more CVD gas right there at the wafer surface) a CVD atmosphere right near a wafer, from causing atoms to be stimulated to bunch up, perhaps with solitons (like dissipative solitons), photons, some ambient, all wafer or just surface wave with less than 100 picometer wavelength, but nonspecific location (like illuminating, but not etching, a wafer with UV), perhaps at a chronological varying dose, like some picometer wavelength UV at 100 billion cycles per second to do 10 picometer bunch up layers at the wafer surface (lisening to a ruler wiggle, a 10 cm ruler might sound like acoustic 100 hz, so a 100 billionth of a meter wiggle might be a 10 picometer sized length wiggle, possibly as a standing wave, which could be beneficial as it stays at the preferred wafer location), the 100 billion cycle per second waves could actually be be beamed from beneath the wafer (or from the side), and some wafer materials might even have findable bandpass layers that are extra transmissive of various wavelengths above 100 billion cycles per second; There are industrial process femtosecond lasers so making the waves is a known technology.
GSK: New kind of drug, but I do not know what it does: Drugs, possibly novel ions, ionic few AMU organic chemicals, or even things like lopsided quantum dots with charge anisotropy, could cause beneficial protein or other molecule specific nucleation effects at cytes, and tissues, notably at a variety of body structures, wikipedia notes that actin tubules come from nucleation, “Energy consuming self-organising systems such as the microtubules in cells also show nucleation and growth.” So they could make a bunch of things that are likely to cause nucleation, screen a library of thousands (or millions or billions) of them at a yeast or human tissue biochip, and see which if any any of them caused greater longevity, wellness, as well as healthspan, previously described is how if you genetically engineer yeast to make more green fluorescent protein then the longer it lives, then you can find the longest lived yeast at something like a big array of wells (a billion or more) on a microchip, where each well has a different chemical and yeast growth medium, and a camera looks at the whole array, and then finds the row and column with the brightest glowing (longest lived) yeast at it. 10 million cyte per second microfluidics flow cytometry is also published and that approach could also be used to screen a billion new nucleation drugs as to longevity, wellness, and healthspan effects at a billion yeast in 100 seconds, or a trillion, to produce a high n P value, in 27.7 hours at one machine. Also, lopsided quantum dots, stabilizing molecules (a little like, but perhaps quite different than antioxidants) few amu molecules, as well as things like eentsiest cyclodextrins, topological starches, and things like graphene toruses, and chelation molecules, could see the effect of reducing nucleation at biochip screened libraries on things like yeast and human tissue culture; notably wikipedia says amyloid blobs at alzheimers accumulate from nucleation, so it is possible there are a variety of nucleation reduction effects which could be beneficial at a variety of human body tissues; Interestingly, as to cryopreservation, novel nucleation producers, reducers, or customizers could benefit cryopreservation of human bodies, freezable and thawable living organisims exist, and these may have numerous simultaneous nucleation, causing, reducing, or modulating chemicals besides comparatively macroquantity chemicals like trehalose at them that people could find, and quantify as to cryopreservation benefit.
semiconductor technology: An Si atom is 110 picometers large, so if you can arrange them any way you like, then a bunch of Si atoms that are at the distal tip of a bunch of alkane like rods, to stick up and be relaibaly equispaced, sort of like the way phospholipid lipid layers have a ===C way of aligning as a
Picometer semiconductor technology: lipid ====C rod layer with distal atom top side up, then lasers, quantum camera spin writing surface action or plasmonics, or reaction torus in the middle of lays on top of it graphene planar form, changes the C to an Si, Ge, Se, P, N, Al, or other semiconductor atom causes purposefully patterned 110-220 feature sized electron motioninging suface patterns on a thing, which has the same function as a semiconductor, notably as compared with a lipid ====c layer you could have silicon polymer, or possibly even boron polymer (boron polymerizes) rods with an atom at the tip, then you change the atom, to make the outer layer surface geometry; notably at he middle of the =====C or ====Si or ====Ge thing you could put other atoms to put stabilization rungs on it transversely, notably whether you removed a the top of a =====Rb, or possibly a =====I, then put a rung atom or few AMU molecule, then put more === on it, or put a K=====Ge or K====Si (or a I====Ga) on it, you make it so the rods could have sufficient rigidity to be nude sunbatyher at Santa barbara California preferred temperature stable, whith the topmost layer of atoms being patterned to do electrical circuits
Neurological plane nootropics: Imaginably a person could think of a nootropic as causing a person to think of things twice as often, one neurostimulant that does this while being highly mild at the organism is simply illuminating an area with twice as much light so that that the persons is able to distinguish twice as many things; Notably at a person this occurs without thinking twice as fast, and can be carried out during a usual duration of wakefulness withouth having much, if any, effect on duration of wakefulness and sleep periods; Also, doubling the number of things, like objects, or simplistically, words, at an area of text can radically change meaning, a kind of bulk-effect salient meaning, or a “if there’s lots of it that’s the idea I get about it” meaning, That suggests that just like the retina is a kind of plane of neurons, something that causes heightened activity of another plane of neurons where the plane of neurons could actually be a physical structure, possibly an actual plane of neurons, like the outer surface of gyrii of frontal lobes, or even the actual plane of AMPA neurons, if there is one at some location of the brain, or if there is a plane of kind of chronologically identical neurons at the limbic system then there is a muliple items of noticing and salience, with simulataneous emotiveness nootropic
Conceptually, if an amygdala could be a “notice it fast” nootropic plane, is there a different nootropic plane where if you notice it, stimulate it, or route data through it, unlike the amygdala, it is noticed as good, noticed as happy, a noticed as happy nootropic plane; noticed as pleasurable might be a nucleus accumbens plane nootropic. It is possible some kind of fMRI or positron emission tomography thing could notice a retina-like plane of simultaneous neural response that is a plane of nootropic enjoyment, happiness, cognitive depth, idea form, “isness” Then just as light only stimulates the retina nootropic plane, it is possible drug localization technology could activate just that actual brain structure physical (likely even simultaneous, like the retina) nootplane, to up it across the board, causing a noot-plane themed cognitive thematization or realization typicality venue, like if you used dissipative solitons
One thing that might be like a plane of nootformness (kind of like a retina is sort of a nootropic plane) is flavor, I perceive I read that there are parts of the human CNS that do not have a blood brain barrier, and that some of these neurons directly direct the presence of chemicals at the circulatory system, and that some of the neurons activate gag reflex when they detect a get rid of it now chemical, get rid of it fast right away, without blood brain barrier filtration or multiplexed neural data from the tongue; so the thing is, as a technology, are there any of these that feel good? A yum! neuron circulatory fluid reaction? Are any of these yums! particularly reinforcing at behavioral psychology? Do different species have different Yum!s? Are there perhaps even different Yum!s that can be measured as having people like them but not actually change the amount of food a person voluntarily consumes? Those could be BMI neutral ways to make food even more delicious.
ok, so: EEG waves: notably people can pile up waves and do things with them on purpose, is it possible to do things like stack and soliton EEG waves to do things on purpose that feel certain ways or even have soliton like ability to propagate further through neural tissues. Like if you make solitons (EEG waves) at the frontal lobes somehow, do they propagate physically further to places like the nucleus accumbens where they do all new things, and at the nucleus accumbens, feel wonderful, at a simpler version can you node or antinode eeg waves like gamma, to put gamma waves at double height, going with the idea they might be beneficial, at the brain, or notably, at particular areas of the brain; notably I think have read that playing eeg waves back into a persons head from scalp electrodes makes it so they learn faster, or even replay the emotional state of the wave, and I even perceive I read that replaying eeg waves back to a persons scalp can cause twice the effectiveess as navigating a computer environement rapidly and functionally,
Writing about beneficial eeg modulation technologies I have mentioned gamma frequencies as beneficial frequently, making all the things I wrote have greater technology beneficialness I would say wherever it says gamma it could say, eeg frequencies that are notably beneficial, notably as played back at particular, possibly varied particular head electrode locations, so perhaps sequencing and head spatially arranging gamma with beta and theta, sort of turning a pie chart into a pie chart with different simultaneous or sequential proportions) and at particular electrode locations causes a particular benefit at a particular eeg modulation sequence program; I also mention that I think that playing EEGs back onto a persons head using electrodes could cause music to be twice as wonderful to experience or more, an application like that might be a non gamma application, but a gamma enriched music experience with another frequency band could combine enhanced wonderfulness of music with the greater cognition and learning of gamma frequencies, and that such a combination of wonderfulness and cognition could be the kind of think where if a person listens to a person speaking tot hem as part of a school lecture then the combination could heighten the actual learning while making the “resoundingness” “thereness” of the lecture higher and more attended to simultaneously; Also, the frequency bands named after letters could actually be immediately replaceable with new frequency and band meanings, effects and designations that arise from something like a deep learning AI classification, a mathematical equation, and a rich dataset could create new meanings about specific frequencies, locations, and naturally occuring multifrequency, even multilocation structures that are more functional as technology that produces a particular beneficial intended benefit than just using some word like gamma
music feeling amplification (eeg modulation making music twice to ten times more wonderful) makes it a thing you would get besides headphones as a consumer getting things behavior
overear heaphones (Like an Apple product that makes music two to ten times more wonderful) that use EEG modulation to make music twice to ten times as awesome could be imitated at many manufacturers, and versions made to work at any phone, or standalone, or like the gelatin capsule slide into hair version produced, valued and distributed
overear hadphones have many places of contact with the head, besides conductive polymers at the ear pads, a casual, put anywhere approach could cause 2,4 9 of the little conductive nubs on the band to touch the head, it could be that a knowledgeable person noting where these electrodes were at ( a traversal location on the mid upper head) could come up with specific beneficial eeg modulation sequences playable to those electrode contact points in particular
Learning from other people speaking amplification; use at school: it is possible that if eeg modulation can make music twice to ten times as awesome then listening to another person talk, such as the lecture portion of school, could be twice as memorable, or twice as attended to; this also benefits persons with different attention span capabilities; school usage is another thing that causes larger numbers of people to utilize it it so it spreads its beneficial effects to larger numbers of people, more rapidly, voluntarily
electrical: nudges to an eeg might be as effective as continually replaying entire eeg waves, repeatedly nudge gamma waves into continuing, possibly even nudge if other waves are present to switch to gamma waves, if nudges work batteries could actually last 20 to 40 times longer
attractiveness producing: eeg modulation that causes it so if a person glanced in a mirror they would think they looked more attractive, continuous with a an eeg modulation sequence program that causes greater benevolence and kindness and prosocial behavior, notably the prosocial behavior could be quantitatively measured as to causing the wearer to be actually perceived as more attractive, and I think quantitative measures of mutual interpersonal benefit could be found at particular eeg modulation sequences and programs.
lovingkindness, benevolence and kindness, cognitive enhancing, and prosocial communication (such that eeg modulation actualizes greater efficacy at employment, greater effective function of personal attractiveness, greater prosocial readiness , form, and reflexes at conversation EEG modulation effects are produced
Along with the music wonderfulness twice to ten times improving eeg modulation program, an eeg modulation wave sequence that causes people to feel noticeably good (ahhh! I like that, felt immediately, while also causing benevolence, kindness, prosocial behavior, and white feeling and behavior) causes people to like using the eeg modulator, as overear headphones or other forms like like tuck in hair gelatin capsules, there is a behavioral psychology reinforcer experience to using the eeg modulator at some eeg modulation sequence (program) that causes people to actually do it and use it, even outside of music
eeeg sequences and modulations, and replayings of the persons own naturally produced, 99th percentile of beneficialness that cause people to be kinder to children and better at raising children are a program, people could just turn it on, and live it, while being around their children as well as others
Besides the over ear headphone version, notably a thing easy for people to associate and get, that makes music two to ten times more awesome, which because it also has other programs like lovingkindness, attractiveness, social and employment and child raising success, the other programs besides music cause people to value the use ofg eeg modulators, and people are thus willing to use non-headphone forms: a form could be something like a skinny gelatin capsule that people tuck into their hair, that automatically cleft gloms some hair, and motionizes to be near the conductive skin area under the hair is another form, with better eeg electrode location functionality, possibly, than the electrode contact points of overear headphones; gelatin capsule eeg electrode location finders could have a 25 cent to $1 dollar store version: conductive polymers at patterns on exterior, the cheapest rechargeable thing I have seen was a plastic toy with suface mount bright LEDs a battery, and a USB mini connector and a plastic saucer shape, so noting that, the gelatin capsules could have an eeg socket, and each gelatin capsule could lightly, softly, roundly, socket together in a line so that one usb connector could recharge three more more socketed together; I think piezoelectric p-lastics could actually cause fronds to furl together to glom hair to avoid slipping off or out of place, and it is possible piezoelectric plastic fronds could motionize the gelatin capsule so that it travels to locations nearer the actual skin under the hair; there is also the possibility that the piezoelectric polymer fronds could could unfurl, or angle to reach out to the skin surface even if a few mm away at the hair;
notably a version, complementary to gelatin capsules under hair version or overear headphones version could be produced that has a camera with audio on it, and it notices what people are around, and who you are talking to, and where you are (dwelling, employment, school, recreation, even entertainment like computing, media, eating/restaurants, commuting (less risky driving, less perterbed more enjoyable driving), even possibly while alseep (along with dream content quantitative measurement as being more beneficial and enjoyable at gamma frequencies, eeg sequences and programs that might be quantitatively measureable as causing better restedness, and possibly even physiologicial improvment could be played) then the camera and audio guided eeg programs could find optimal eeg programs and sequences for the people you are around and the things you are doing perhaps the thing might notice you are with a spouse and a stranger at a restaurant, but not with your children, or might notice you are with your children, playing together, outside, it could up (with spouse and stranger at restaurant: eeg program that quantitatively measured as casuing more spontaneous interjections into conversations, food appreciation eeg, previously measured actual to the actual human spouse 99th percentile affection causing eeg), or at playing outdoors with the persons actual children, it could do eeg programs with more occurences of mutually enjoyable beneficial touch, spontaneous production of beneficial questions, (questions as prompts to the children making replies and the children enjoying the conversation even more) as well as possibly eeg programs that are quantitatively associated with perhaps twice as much strolling, also there might even be eeg modulations programs that cause various prosody of enjoybale emotion to the listener generation, eeg modulations that cause what other people perceive as emotionally nearifying, sweet conversation, even though the person is thinking of their own content and making thought of as well as spontaneous content responses at conversation)
So, this brings up an EEG technology: I have seen EEG brain readers with just a few electrodes (2, 4 8?), so if you do nodal, antinodal, and soliton structures is it possible to do much more with 2, 4, 8 electrodes, or do 8 or 16 electrodes worth of activity with just 2 or 3 electrodes? Also, at a really casual, just put it on your head, no-gel, electrode hairpiece that has 16 or 32 electrodes, 4 or 8 of which might happen to actually make contact, and which might be about 1/2 a head near to the “preferred placement”, can you get a nodal, antinodal, soliton EEG activity, possibly with AI, deep learning, or software guidance that makes the “1/2 a head away, 1/4 or 1/8 the electrodes actually making contact” EEG reading and feedback, nootropic, emotionally beneficial, benevolent computer brain interface, and possibly even, lay on a pillow while you sleep and do physiologically beneficially nonspecific to thought beneficial physiological things brain communicator functional technology
Also, noting the 1/2 a head away, a few out of 16 or 32 electrodes make contact EEG hair accessory, laser hat, very casual, at classrooms version (note gelatin capsule sized slipped under hair with piezoelectric contact and motion fronds version as well as overear headphones version) could heighten voluntary learning of students at classrooms, as well as heighten voluntary learning of persons, that is humans, that is people that is homo sapiens at office environements; also it is possible that beneficially at babies and children, this technology causes emotional well being, nootropic effects, and could even rescue babies from harm, detecting any SIDS brain preactivity
Also, the 1/2 near the right place, a few of the electrodes contact hair piece might go well with laser activated, energized, and communicating adhesive eardots
Note: eeg modulation programs could be quantitatively measured as to their longitudinal effectiveness at causing benevolence, kindness, prosociality, interpersonal, family, and child communication and child raising, employment beneficial, promotion, earnings, employment satisfaction, reduction of vehicle non-optimal occurences, possibly physiological wellness, less illness, well restedness from eeg modulation during sleep, and the amount of subjective well being, successfulness at using the new options found from greater openness to experience, and beneficial treatment of others, get-up-and-go, optional conscientiousness, greater duration of enjoyability of the action during stick-to-it-iveness activities’ beneficial heightening and multiday, multimonth, multiyear sustained longitudinally quantified beneficialness of various EEG modulations programs, software, and physical technology objects (like measurement publication, and product benficialness heightening version iterations from finding out something like soliton nodal nudges at gelatin capsules with fronds are more effective, more often utilized than over ear headphones, have greater global utilization from 25 cent to $1 form factor, and that RF or RFID communication with phones or something like dwelling wifi is awesome, but that (noting scientific calculator with LCD display at dollar store for $1 technology) gelatin capsules with standalone eeg recording, 99th percentile of persons own cognition, feelings, motional, wellness, interpersonal interactions) interpretations and remodulations, along with library eeg modulation software produces 90% of the benefit that wifi phone rfid RF bluetooth internet versions produce, while internet versions really superoptimize eeg modulation programs that are beneficial to cognition, subjective well being, and at internet content production, content richness, and others response to the content produced, at a computing environment like an internet browser, at a place of emplyment, or when a person like an engineer or a scientist using CAD or software or programming is actively using computing
Do cognitively unwell persons, like the mentally ill, or those with things like alzheimers, when part of their own brain waves, from just part of the surface area of their head, are played back to them, likely at a plurality of locations on their head, experience greater mental wellness or cognitive capability; as a technology a mentally unwell person might still produce gamma EEG waves, just mostly at just next to say one temple, or near one part of their head, then playing that persons own gamma waves back to them, at their particular version of the actual gamma frequency (its a band, and they might have a specific frequency at the gamma band) specific frequency, at a variety of greater number of brain electrode input locations, and brainwide, electrodedeliverywide rebroadcasting of that particular actual persons gamma wave modulations (kind of like the tune of gamma waves they play) to all around their head, cause beneficial, enjoyable, voluntarily repeated and used brainwave modulation that also causes them to be measured at psychological tests to be mentally weller, or noting things like alzheimers more cognitively capable, notably, as these are waves they already produce, they might be thematically with like a person being a person, even more like they already are, while voluntarily heightening their mental well being and ability; kind of nifty to play and amplify your own version of gamma waves of EEG
also, among those that do do it, software could have them voluntarily experience various congitive styles g (intelligence) activation exercises, and emotions (videos, music, website content, like unique to the person: reply, comment or online response based social content) record the brain waves from when they are at their upper 90th percentile of even 99th percentile of personal g (intelligence) active utilization, capability, and finding the right answerness, as well as their 90th or 99th percentile of emotional subjective well being, benevolence, kindness, or beneficially, a combination of goodwill with conscientiousness and sustained carrying-out of action. Then note those particular frequencies of actual EEG waves from the actual person at something like the gamma band, and those particular head surface area locations to play the EEGs back to, noting the nodal, antinodal, as well as soliton EEG enhancement effects also available
Also, noting the very most causual, user-participation willing and utilized, about 1/2 a head away from the optimized location versions of EEG brain interfaces, where they make different versions, possibly some that tend to make people always think they look nicer, and find one that that almost everybody, with casual lack of fuss, perhaps as easy as foam earplugs, piezoelectric frond gelatin capsule sized eeg modulators, as well as overear headphone versions
A well being, cognition, and emotion hightening EEG electrode brain communicator that is comfy, effortless, affordable, autorighting, and autoconnecting, and autoupdates data readers without making RF fields: amazingly, something a little like a corduroy or piezoelectric polymer frond having skinny golf pencil to 14 to 20 mm long, 3-7 mm diameter tube, about the size of a gelatin capsule with a battery in it, could wiggle the corduroy on the outside, or move the piezoelectric fronds, to always nestle nearer to the skin under the head hair, while being completely different than array-of-candycanes and puffyfluff physical adhesives, and being completely different than clamps, have a kind of soft looks like a ribosome next to some hairs thing it does, so it omits slipping off could be a slip-on electrode with a good feeling slide onto your hair, omits falling off, can even without generating radiofrequency energy be read like an RFID tag, 700 factorial data space, 300 reads per second MEMs like continuously microrepatterning thing like RFID tag so that the RFID reader, laser scanning of the thing from a distance with a multiplexed display surface, or have a ThZ frequency visible display (LCD like) change so that it is possible to have a Thz sensor actually see through the hair at a distance and scan the Thz display pattern. It is possible some chemical variation on a 300 hz, LCD display with 1024 liquid crystal elements, where each of the LCD adressable dots is made from a ThZ modulating chemical like a bismuth metal atom at the liquid crystal molecule is a distance readable 300 Hz data source
RFID MEMs origami that changes its physical shape slightly to make RFID readable data space without any actual RF broadcast from the object:
It might be a big dataspace: 700 integer space factorial RFID that changes its RF responsiveness from MEMs at 700 factorial different data values it is possible that at 300 Hz (like LCD driver, and although there are a variety of RFID forms, changing the shape of an metal rish liquid crystal LCD blob could actually be an RFID object) this could communicate updates 300 times a second as well as have the RFID store some amount of previous snapshots of actual EEG output at the person, noting the factorial space, it is possible 700 factorial could represent multiple centuries of EEG data recorded at 300Hz
Some thing at phones where something has, more than a bluetooth ID, an instant shared automatic data update database compartment, where anytime the thing is brought near the phone, its compartment identity data is appended with the new data. So rather than “synch” a smartwatch with a phone or computer, the mere presence of the smartwatch, health monitor, EEG recorder, data depot, like say a person has a data depot where not only is the video and audio and other data from the cameras on their body continually aggregated and concatenated, but the social norm automatic protocol is to have all the video, audio, and other data cameras around the person wherever they go upload their data to the person, that is human’s that is member of a group of people’s that is homo sapiens’ data depot, that data depot is automatically uploaded to the persons’ phone, computer, and the phones computers and data depots of those that have configured their data depots, phones and computers to I’m nice configuration (a little like when other people make their wifi public, give to food banks, donate to strangers that ask for donations, or say things like “good to see you”; lots of people would automatically gather and store and make public data) I think the storage per microgram will go up, at 2019 AD a terabyte of data is plausibly anywhere from less than 10 micrograms (data storage variant on DNA with a few thousand different nucleutides as rung options) to 100 mg (microSD card)
Nonsexy, but, genital sourced nootplanes that are beneficial
Banishing lonliness with a 1000 year functional depot injection or possibly as a combined effect with another drug could cause 26% less mortality, ““Imagine a condition that makes a person irritable, depressed and self-centred, and is associated with a 26 per cent increase in the risk of premature mortality,” Cacioppo and her late husband, John Cacioppo, wrote in The Lancet last year. Around a third of people in industrialized countries report feeling lonely, one in 12 severely so” https://nationalpost.com/health/all-the-lonely-people Notably the steriodal hormone pregnenolone has been researched as an anti-loneliness drug, and as a sex steroid like molecule could have ethynylization as well as halogenation as effective dose multipliers; the first page of a search engine suggests 10 times greater effect per dose, if ethynylization is 8 times greater dose efficacy then 80 times fewer micrograms per dose could be possible; at .625 mg as a daily estrogen dose, and 300-800 nanogram/24 hours at ethynylized estrogens or possibly progesterones (progestins), the fluorinated version could be active at 30-80 nanograms/24 hours, or a .333 gram depot injection providing 365,000 to one million gradually diffused 1microgram to 100 nanogram doses at a one office visit dose treatment for loneliness, a 1000 to 10,000 year duration of loneliness reduction if pregnenolone has a ethynyl and fluoro dose amplified form. If a lymphatic system applied depot form of ethynylated halogenated progesterone is possible that approximately quadruples physiological availability from omitting first pass metabolism; if a blood brain barrier passing moeity is a possible modification as well a two to ten times greater availability at the CNS, a possible location of feelings of loneliness could be possible, so 80 nanograms /4 /2 is 10 nanograms per 24 hour dose, permitting an approximately 40 milligram 1000 year duration depot injection dose. Notably, if it is possible to make an oral depot version of a drug, possibly from antibodies linked to palmitates, with the antibodies specific to lymphatic epithelia, then at 10% efficiency compared with an injected depot a 400 mg depot producing oral dose with 1000 year depot functionality of a ethynyl fluoropregnenlolone could be possible; gene therapy or also germline gene therapy to produce more pregnenolone, or shift to personality genetics that is absent feelings of lonliness; also noting that the big five personality test trait areas are about 50% heritable, and that a new personality test where, like the minnesota multiphasic personality inventory the questions were correlated, winnowed, and enhanced to be predictive, it is possible a 97-99% genetically predictable paper question or also software psychology test with completely fresh new traits that could also be called themes could be constructed. If some percentage of these traits or themes that are 97-99% genetically predictable are the kinds of things people would change to improve their well being, efficacy, ability, and prosociality, reduce or prevent loneliness, while maintaining or expanding creativity and initiative then those are rapidly eugenics addressable traits and themes that could also be gene therapy opportunities.
Addressing loneliness with depot drugs or causing greater plasma levels from less pregnenolone metabolism, whichever is more physiologically beneficial could reduce mortality 26%. It is unknown if numerous species of mammals along with humans experience loneliness, gene drive could banish loneliness at perhaps all mammals; the effect on frequency of mating and the number of progeny is unknown, but imaginably increases among all mammals that experience an absence of loneliness.
Moieties that cause higher physiological availability and physiological activity at a particular mg (or mcg or ng) dose; I read that halogenated drugs are less metabolized at the liver with things like CYP enzymes, that gives longer plasma duration, as well as possibly omits first pass metabolism, causing, imaginably, 90% or higher amounts of the drug to remain fucntional at the circulatory system; It could be that there is a kind of drug visiting and detaching from receptors many times, as well as what I previously thought that halogenated drugs glom on to receptors and have long residence intervals from their high electronegativity glomming and staying on a receptor; also it is possible that halogenated drugs, as well as other drugs, which get some of their durability from plasma from glomming to albumins, globulins, or other plasma proteins could have versions that glom to plasma proteins twice as avidly, or perhaps are absent any plasma protein glomming; a fluorodrug without plams protein glomming might go almost completely unmetabolized at the liver, yet have a tissue available dose 7-9 times higher from an oral or other dosing; alternately, double duration plasma protein glomming
screen a library: radiolabelled or fluorophore labelled halogenated drugs, a few thousand, million, billion, or at a 300mm integrated circuit wafer with 1 trillion wells
Rapamycin, with like a trifluoro (methyl group like with three fluorines) that has 16 day or longer plasma half life, different plasma protein glomming could be an even more effective enhanced human longevity drug, from persisting at the circulatory system longer; noting the mice that lived 60% longer from 126 ppm rapamycin had frequent meals but, I perceive I may have read, 9 minute rapamycin plasma half life, and I might have read human plasma half life of rapamycin might be .9 hours while wikipedia says 57-63 hours; higher plasma protein glomming of a rapamycin; wikipedia says rapamycin is 92% protein glommed, there is some possible greater sustained rapamycin longevity effect there that could be produced and be beneficial; wikipedia says, “ Since albumin is alkalotic, acidic and neutral drugs will primarily bind to albumin.”; Although a trained professional would know much more, the longest plasma half life of a drug I am aware of is norfluoxetine, 16 days, 384 hours; perhaps the chemistry of such drugs (trifluoride like a methyl) could be used to produce even more beneficial, possibly even more longevizing variations of rapamycin, noting the mice were likely eating food perhaps every few minutes at the 126 ppm enteric coated rapamycin dose; At the rapamycin molecule I read that a /\/\/\/\ with numerous \=/=\=/=\=/ is thought to be the mTOR active part of rapamycin, and it has a methyl on it that if replaced with a trifluoro methyl like moeity could cause the ten times greater plasma half life. It is different than other things I have read, but wikipedia says ascorbic acid has a circulatory system half life of 83 days, with an eleimination constant of 4 months, that suggests something as simple as screening a variety of locations of an ascorbic acid moeity could make a 3 month dose of a longevity producing rapamycin varaint; also I perceive I read that rapamycin’s oral absorption has to do with rapamycin’s nonsensitivity to pH, a rapamycin ascorbic acid version could have higher effective drug absorption at a particular mg or ppm at food dose;
Longevity drug: 126 ppm rapamycin is published as making mice live 60% longer, it is my perception that I read this has to do with reducing mTOR activity, notably though mice with mTOR -/- genes, which I pereceive as meaning they have zero mTOR receptors live 20% longer; It seems possible that at mammals with mTOR receptors the mammals might also be making previously unstudied slightly hormesis-like chemicals that cause other changes at the body to compensate or emeliorate for having mTOR receptors, and possibly reducing the activity of things (networks) connected to mTOR receptor activation; those slightly hormetic like ameliorators persist at the mammals when rapamycin causes the 60% greater mouse lifespan yet at the -/- mtor mice are minimally there ( genes that produce the ameliorating chemicals) as they do not need to be. Finding those physiochemicals, likely proteins, receptor proteins or material at the cytoplasm then adminstering them to mammals as separate longevity chemicals as drugs could have the 40% longevity increase that could be linked to 60% increased longevity mice (minus) 20% at mice with no mTOR receptors; At humans, production of these chemicals, proteins, or peptides could be endogenous with germline gene modification or also gene therapy; The possibly attainable 40% greater longevity from other mTOR receptor presence ameliators might even have different tissue or cyte localizations, potentially concentrating longevising effects, or finding areas to bring up to the body tissue longevity increasing median, which would cause greater youthfulness of phenotype as well as greater longevity; looking at all the mRNA that rapamycin causes the production of, and comparing it to the mRNA that the mTOR -/- mice when adminstered rapamycin make could find the ameliator 40% greater longevity genes and chemicals, just administering rapamycin to the mTOR -/- mice could find the 40% longevity mTOR ameliorating chemicals, genes, and proteins or peptides from mass characterizations at all the proteins and peptides produced at the mammals.
Moving a math distribution of longevizing drug effects with bulk-effect different longevity drugs, and comparing that to a conctenated tissue and cyte approach; is there published research on the distribution of phenotypic and genotypic youthification of form (variously somatic form or things like telomeres or mRNA expression profiles) at different cytes and tissues, It is possible an equation, computer model, or predictive AI would be much better, although one way to think of this is like a histogram; if the histogram has a normal distribution then 32% of tissues and cytes are high longevity responders, 68% are at the first standard deviation; broad-group differences in distribution shape, and addressing which cytes and tissues are at what standard deviation could be a programmatic way to find composite longevity drug combinations that cause a chemical that causes the phenotypic or also genotypic central standard deviation of one drug to be at the 2nd standard deviation of longevization with another drug; this bulk mathematical effect complements the other idea of finding things like: one thing functions at adipose tissue, one thing works at neurons, another thing works at the cardiovascular system, another works on preventing cancer then assembling a multitissue multicyte addressing multidrug blend; both have value, it is just that addressing entire distributions to move up an entire standard deviation of longevity increase could be accomplished with particularly larger affordability, and simplicity.
Numerous math approaches, or groups of drugs/activities/genetic enhancements could be numerically modelled or equation limned to find the component groups that most functionally cause longevizing distribution standard deviation shifts, overlays, and complementary groups; Receptor based, like AMPK and less mTOR, ILGF-1, and possibly receptors activated from published as causing 25-27% greater mouse longevity royal jelly chemicals or proteins, could be a standard deviation described group; then a completely different chemical group of nonreceptor longevity increasing drugs could be another distribution group, like senolytics; a third group could be what I read about that might be called “mortality reducers” epithalon combined with thymosin causes four times fewer people to have mortality events after six years, preventing, curing, or also genetically precluding loneliness reduces mortality 26%, I perceive there are other mortality reducers; another producible group that could actually cause standard deviation overlap and movement of more things to second deviation or higher of greater longevity effects is to just make lipophilic and hydrophilic variations on the most effective longevity drugs; a hydrophilic and lipophilic version of the rapamycin molecule and other receptor molecules, a lipophilic and hydrophilic version of senolytics, a lipophilic and hydrophilic version of 17 alpha estradiol, a lipophilic and hydrophilic version of the 25-27% greater longevity royal jelly proteins or other chemicals; Also possibly lipophilic and hydrophilic and lymphatic system versions of what might be non-receptor longevity drugs like spermidine, immunizations, and NMN, could each modify the distributional histogram of effectiveness, which might be a normal distribution at any one group of longevity drugs that could combine to move as many tissues and cytes as possible to produce an almost three-phase power like graph with all three phases being at the second deviation (upper 32%) of higher of longevity effect.
A three of four drug blend that shifts entire distributions could have, perhaps based on the math of drug combination alone, many fewer numerically predictable side effects or contraindications than a 400 tissue or 400 cell type multihundred drug composite. Then again, if each of the 400 drugs or gene products individually causes greater longevity and wellness, then their harmlessness might be kind of definitionally adequate, sort of, if it makes you live longer, and makes you weller, its harmlessness is definitionally adequate. Note though that testing and time to commercialization could be much quicker with 10 highest effect longevity drugs times 6 variations (lipophilic, hydrophilic, halogenated and ethynylized, depot form, lymphatic area, gene based, ) than testing and time to commercialization of a multihundred drug form. Notably though there are numerous opportunities for tremendous benefit from individual drugs as well, gene therapy or also germline modification to produce longevity and mortality reducing peptides (epithalon with thymosin 4 times mortality reduction)
Mass screening of longevity drug candidates with vertebrates: Fish: some fish (a goby) have median lifespans of 60 days, others like guppies, 2 years; A fish listed online is .55 inch (1.4 cm), Danionella, “When the genus was first described, these fish were classified as the smallest adult vertebrates to inhabit freshwater”; Other fish in the .75 inch to 1 inch size are described at https://www.myaquariumclub.com/nano-fish-for-small-aquariums-5134.html; Some fish may have greater cognitive ability than some other fish, “Dwarf puffers are one of the few species of fish that interact with their environment and owner. They will happily greet you as you approach the tank, and can even learn to be hand fed.”; another consideration for mass screening of longevity molecules and longevity genetics and wellness molecules and wellness genetics at vertebrates is absence of aggression; it is possible that at a communal growth tank frequent fish-fish interaction of a nonpleasant nature could affect physiology, actual physical integrity, and even the effects of stress on longevity;
Mass screening the fish: at 1 second per fish, a 3d printed 100 fish hydrosorter processes 1 million vertebrate fish for longevity drug efficacy at 10,000 seconds or 167 minutes (2.8 hours); A different engineering version: noting tube lengths, even with green light causing many fish to prefer forward travel, at 10 seconds per fish, and a 1000 fish (32 times 32 grid) hydrosorter process it is also 2.8 hours to characterize and label 1 million fish; 117 days screens 1 billion fish.
The hydrosorter could be 3d printed so a fresh, absent algae coating, predictable fluid flow hydrosorter is available anytime. One Kg of 3d printing filament is $29; If the hydrosorter has a mass of 1 Kg or likely much less, then a 3d printed version is $29 That makes CAD development of greater and greater efficacy hydrosorters more rapid, and causes the most complex part to be $29, disposable, and like PLA (polylactic acid), physiologically compatible and harmless.
At the growth tank, fish can be taught light stimulated fish behaviors, green could mean swim towards something, possibly a food source that will dispense food in 2-7 seconds; Blue light could teach the fish to be stationary in the water, possibly facilitating imaging, Aqua light could be linked to the learning of a 3-7 sequence action the fish could perform for the cameras at the hydrosorter, providing data on cognitive effects at progressive living, White light could teach fish to expect change without stress; perhaps a mini version of the hydrosorter at the growth tank, only without the cameras, lasers, and other imagers;
Cognitive or cognitive like-distribution shifts, could be measured at the hydrosorter, with accuracy of the aqua light learned sequence, and with efficacious cameras and software, inter-motion time, kind of like velocity of recall; To keep fish moving through the 1000 channel hydrosorter there could be green light stimulated fish preference for forward travel,
To label individual fish for further study, GFP or another photoshiftable color, then a laser, absent effect on actual fish tissue, barcodes the fish with photochemical modification of just the GFP at 1 million fish labelled each 2.8 hours, also, all the fish that go through the hydrosorter, notably the labelled fish, can be reused from the after hydrosorter tank, to multiplex treatments; Also, fish the software notes to be of particular interest, like the youngest phenotype fish out of each million, or if the fish seem euphoric, unusually physically active, or displays mating behaviors at the camera area of the hydrosorter then those effects, potentially beneficial at mammals, can be linked to the longevity chemicals and genes being screened;
There are numerous ways to administer longevity drugs to fish, the hydrosorter could dispense a couple drugged food pellets at a particular area of the hydrosorter, where the mechanism at the hydrosorter could utilize something like n=40 for each different longevity drug, to administer 25,000 different longevity drugs in 2.8 hours, if the fish get 3 hydrosorter administered doses, separated at 24 hours each, then a full hydrosorter imaging, that is 11.2 hours spread over 96 hours at an automatic system; I once had a motorized automatic fishfeeder that was about $29.99; Another possible way to administer drugs to fish is to have something like an inkjet printer spray them with a gelcoat, another way is to have the hydrosorter have the fish breathe drugged water through their gills for a minute at one area of the hydrosorter;
Fish vertebrate research supporting well and longevized human babies: one benefit of using vertebrates like fish as longevity drug development and effectiveness verifiers is that some fish are livebearers of young, this provides an opportunity to see if there are any beneficial new drug distribution shifting effects of well progeny; it is possible some longevity drugs as well as genes actually heighten fetal and baby wellness, scanning a million fish in 2.8 hours is one way to find drugs that can then be tested on mammals like mice to find out if fetal and baby well being are increased at mammals as well.
The hydrosorter could be a little like the top view of the internal crenellations of cardboard at about 14 mm width, with sensors tht can see through the 3d printed polymer or a transparent plastic plate on top of the hydrosorter, so one or more cameras can image the 1000 simultaneous fish for software processing; Notably things like THz imaging of the fish could work through the 3d printed polymer and the software could record things like organ size and skeletal density, and gill respiration rate, and heartrate, Also, light cameras placed at CAD optimized ports at the 3d printed hydrosorter are also possible, and general soft illumination provided through the 3D printed volume with external lighting;
With positron emission tomography and radiolabelled physiochemicals like like radiolabelled longevity drugs that effect neurons, radiolabelled neurotransmitters, other tissues and molecules, as well as concentration and multiple measurements with time activity at the physiological tissues with the least vascularization, Then variations or shifts from the longevity drug molecule compared with untreated fish’ distribution of tissue activities and neural function can be gathered as data at a computer and mapped; it is also possible that noting the 25,000 groups of n=40 fish (1 million) screened each 2.8 hours, that a variety of longevity drug localization effects will be found, and finding out which chemical concentrates where has longevizing and wellness value.
One use of the unique fish ID produced at something like a laser on GFP is the production of a library of frozen fish, possibly with detectable mRNA activity or things having other technology and drug development value, live clonability from the frozen fish, also detailed study of the 20-100 most efficacious longevity drugs’ per million fish characterized effect on things like cytoplasm, reproductive anatomy (sperm, eggs, livebearer growth areas), brain morphology, telomere length, cardiovascular fitness, cancer amount, and immune system effects;
One area of longevity molecule research doable at fish at a hydrosorter, is the longevizing effects of reducing the amounts of some molecules from tissues or at circulation; It is possible the hydrosorter could be used to administer gill-breathable antigens (immunizations) against things like interleukins, sex hormones that are absent effects on secondary sex characteristics yet have cardiovascular risks or carcinogenic effects, liver enzyme saturating endogenous chemicals, mTOR activators, ILGF-1 (and similar molecules), endogenous telomere length reducing molecules, endogenous AMPK activity decreasing chemicals, possibly some versions of cortisol-like molecules circulating endogenously, physiochemicals that get upregulated when organisms miss sleep and could be deleterious (missing one night of sleep doubles likelihood of infection at a human); peptides (or proteins)that cause stress, possibly like deleterious versions of beneficial peptides (or proteins) that occupy beneficial receptors, but have zero or negative activity, keeping the beneficial forms of those peptides (or proteins) from reaching the receptors and providing benefit, various lipopolysaccharides that might reach the circulatory system from the GI tract, histamine, the physiological chemicals produced at gum disease that I read is like 20something to 48% active at causing cardiovascular disease, Any endogenous physiochemicals that cause heart rythms outside the wellness standard (although these are of course fish), as well as, noting that a combination of epithalon with thymosin causes four times less mortality during six years at humans, any chemicals that occupy epithalon and thymosin receptors causing those receptors to not function at preserving living function.
A peltier enabled hydrosorter used at fish could also be used to develop cryogenic cryoprotectants to support human cryonic preservation and revival.
Eugenics: The 3D printed hydrosorter could also be used to research a variety, notably a screenable library of 100,000 or a million freeze dried sperm preservatives to find those that produce motile egg-seeking sperm on rehydration, a technology that benefits eugenics, and can cause the manufacturing cents of a sperm emitting vaginal decal or also paper applicator vaginal canal 60 day attaching paint that continually emits genetically enhanced or also genetically optimized sperm to be about 11 cents a month, or 1.21 annually. Notably, 25,000 different drugs and preservatives can be screened on 40 sperm each 2.8 hours. Screening a billion freeze dried sperm revival with motility molecules, concentrations, and chemical treatment sequences is less than 120 days. Another technological from is a $4.14 5 gram polymer near cervix circlet that would gradually release 11 mg of motile previously freeze dried sperm every 24 hours for over a year, causing the likelihood of conception to be at 99% during the first 14.2 months of use among those persons capable of becoming pregnant
Gene therapy and gene drive on fish: At fish in the wild it might be notably effective to gather wild fish in multiplenum nets, where the netting is coated with gene transfection gel, and then the fish released after a 1-14 minute interval of gene transfer to transfect what might be millions of fish with gene drive every 24 hours, with 100 days from one boat causing 100-200 million gene drive enabled fish to communicate gene drive to other fish in the ocean, providing benefits to fish like removing all nociception as well as decreasing nipping and fish social behaviors humans find ethically beneficial to obviate.
Beauty genes that decrease risk of cancer: It is possible that female sex hormone receptors like estrogen receptors have a genetic 100 to 700% different amount of responsiveness to the same amount of circulating estrogen, progesterones, or other sex hormones, that the size and shape and optimizability of human female secondary sexual characteristics like breast size and shape and soft skin and even body form (like I have heard of banana shape and top heavy hourglass) could be enhanced with human germline genetic enhancement of estrogen receptor responsiveness to be at the 700% range, notably actual circulating estrogen could be the 2019 median amount or possibly shifted to endogenous estrogenic, progesteronic, or other sex hormone chemicals with just 10-50% of the cancer risk of 2019 AD median estrogen amounts or also particular estrogen molecule types, so this gives women and girls even more beautiful body form while reducing cancer risk 50-90%.
There is a possibility that a technology that immunizes against background endogenous amounts of the chemicals produced when a human misses sleep reduces developing infectious disease, precluding, like with immunization, these chemicals, that are around even when a person gets a normal amount of sleep, could reduce the incidence of many, or most infectious disease; I perceive I read that missing a night of sleep doubles risk of infection, it is possible that is from the production of some chemical, or the activation of some receptors, it is possible that those chemicals, at different amounts, or receptors’ activation even when a person sleeps normally has some background amount, and that an immunization against those chemicals could reduce the amount of illness the amount of even persons that sleep normally get. it is also possible that germline genetic engineering as well as gene therapy could quantifiably reduce infectious illness of many kinds through causing less of the sleeplessness producing physiochemicals or receptor effects at persons that get normal amounts of sleep.
New genes to optimize and enhance the human germline: I favor publishing all the material I have written, among those materials are notebooks; there is material written in notebooks as well as online material I have published favoring enhancing as well as optimizing the human germline, that enhancement as well as optimization can be the result of engineering completely new genes as well as enhancing or optimizing combinations of genes that already exist during 2019AD.
Raed that during 2019AD pediatricians recommended that babies not sleep with anything in their cribs other than a sheet, perhaps this will improve but until it does, it is possible a flocked sheet with extrasoft flocked patterns on it, like velour macroscopic swirls could be a variation that the baby actually likes feeling the variations of, and where the baby like might moving over towards might be a beneficial enjoyed thing to put on baby sheets
I read that liposomes that travel to the lymphatic system cause some drugs to be 390% more absorbed, that is have 390% of the plasma levels as other oral drugs that go directly to the circulatory systen; could that be increased even more with the genetics of having a lymphatic system with twice the permeability of drugs, twice the absorption suface area, some of both; noting the way the immunoeffectiveness of the body goes with the immunofunction of the lymphatic system could that double the effectiveness of the immunosystem reducing infectioious disease, possibly also reducing cancer incidence as well; the human lymphatic system likely has genetic variations which could be sources of beneficial one dose lymphatic system gene therapies as well as genetic enhancements and optimazations of human beings that is persons that is people; it is possible longevity technologies could be amplified as to their effectiveness with lymphatic system enhancements
prenatally beneficial PQQ, “Dietary supplementation with PQQ·Na2 significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk.”
Could customized sugars cause localization of drugs at the brain: GLUTS (glucose transporter types) with different genetics might have different transport amounts based on their different genetics and actual protein shapes, perhaps one is twice as effective as movinh ribose, or another omits transporting highly deuterated glucose; these could be used not only to “feed” brain areas moe than others, but to be made into moeity attachments to drugs to get brain area or neuron type localizations, “membrane proteins known as glucose transporters (GLUTs) (Shepherd and Kahn, 1999). Though numerous GLUT isoforms (1–14) have been identified and characterized, only some of these transporters are expressed in the brain and can be involved in neuronal homeostasis and brain function (Duelli and Kuschinsky, 2001). Specifically, the insulin-independent transporters GLUT1 and GLUT3 mediate glucose uptake into glial and neuronal cells, respectively (Simpson et al., 2007), suggesting that the impact of insulin on synaptic plasticity should be independent of glucose uptake.
Moreover, GLUT2 and GLUT4 expression has been characterized in specific brain areas: GLUT2 is predominantly localized in the hypothalamus that regulates food intake (Eny et al., 2008), whereas GLUT4 has been identified in cerebellum, neocortex, and hippocampus, suggesting a role of GLUT-driven glucose uptake in neuronal activity (Vannucci et al., 1998; Sankar et al., 2002). GLUT4 is also expressed in astrocytes and insulin stimulation promotes both glucose uptake and glycogen accumulation in astrocyte cultures (Heni et al., 2011).”
A longevity immunization: online it says there are things that reduce autophagy, an I perceive I read that autophagy is linked to younger phenotype, so are there any naturally occuring proteins or peptides that reduce autophagy? Immunizing against those could be a one dose treatment that causes the body’s own reduction of autophagy to be less, which then increases longevity and phenotypic youthfulness. This could be a part of childhood immunizations. “Experimental suppression of autophagy in the absence of stress is tolerated by the rapidly renewing epidermal epithelium, whereas long-lived skin cells such as melanocytes, Merkel cells and secretory cells of sweat glands depend on autophagy for cellular homeostasis and normal execution of their functions”
Longevity technology:
Longevity gum, “More than 100,000 tons of chewing gum being consumed every year.”, of cavity preventing xylitol gum, “dentists from all around the world recommend daily ingestion of up to 5g of xylitol (around 9 mints or 3-5 pieces of gum per day” So if people chew five pieces of gum per day, 1825 pieces a year; 730 million or 1 billion gum chewers is plausible at a little over 10% of 2019 global population, and at 1825 pieces a year that is a little less than 2 trillion sticks of gum a year, at 20 pieces of gum each 24 hours per chewer that is 8 trillion pieces of gum. At a one cent premium per piece of longevity wellness gum that represents 80 billion us$ annual revnue from longevity and wellness increasing chewing gum.
AEDG chewing gum, also if a levo and dextro amino acid version of AEDG is found to be longevizing and wellness causing then AEDG could reach the GI tract for absorption.
Lithium at gum: Lithium in the water supply is correlated with people living longer, and makes laboratory nonvertabrates live 9-20% longer. If a flavor neutral or yummy lithium gum additive can be found, which could possibly arise from linking a 10,000 times sweeter than sugar sweetness peptide to lithium at a stomach dissolvable lithium chelator molecule, then at 5 sticks a day, and 5 mg of lithium per day, then 1.001 to 70 mg of delicious combined lithium/sweetness peptide/chelator molecule would be at each stick of gum.
Also, they can put anything, at perahps 200 mg at liquid center gums like chewels.
Some chewing gums may already have a peptide/peptone/protein component. calcium casein peptone is a texturizer at chewing gum, “at a use level up to 5% wt/wt”
Production of beneficial drug peptides from milk (casein) and grain (gluten): Modified proteases like trypsin could make different digestion products, some of which are drugs. Genetically engineered organisms would make the new proteolytic enzymes with customized products, which would then turn other things into beneficial medical peptides affordably. This brings Genetically engineered production’s product affordability to natural products.
Even more affordable than engineered enzymes: plants that make modified gluten with trypsin or pesin dividing regions that repeat, with a peptide of value between them: Also, as plants produce glutens, it is possible that producing Genetically engineered organisms with the sequence (trypsin or pepsin cleavable location) -peptide of value-(trypsin or pepsin cleavable location): as the peptide-of-value-polyrepeat at genetically modified gluten could produce a highly affordable source of beneficial peptides.
Modifications of gluten to produce valued peptides released from digestion with ultraffordable already available bulk trypsin or pepsin:As a system the technologist would just swap in the amino acid sequence of interest at the -peptide of value- location at the genome. During about 2005 AD the barley lab I worked at would get about 3 successfully genetically engineered plants for every 100 prepared (embryo sliced, soaked in transfection liquid, agar placed) barley embryos suggesting immediate rapid production of over 200 different versions of gluten with different -peptide-of-value- per researcher per year using very simple technology I was able to use with 1 hour of training; the technology I used likely has transfection efficiency and hourly production with new variant protocols that are 10 or 100 or even 1000 times more productive from automated slicing and multiwell plates.
It could be nifty if taking a protein with amino acid (peptide-like) sequences that already have bridges (like S bridges or different bridges) and then putting something like a trypsin or pepsin-division sequence at the four corners of the bridge :-:, would then produce a variety of different customizable bridged peptides easily and reliably; they could even make an enzymatically attachable spacer amino acid string of genetically variable length to place between the two bridge sides like n or n that would predictably provide the right distancing of briding amino acids to favor amino-acid bridging. This likely already exists.
Can a trypsin or pepsin (notably a chemical variant that does not interact with the protein source, like milk, until the hydrogen ions in the stomach modify the trypsin molecule) be swallowed with a food, like a trypsin or pepsin milkshake, to produce a biologically active peptide in the stomach or even other parts of the GI tract?
Casein, the 80% of milk’s protein protein is processed like, “manufacturers combine casein with calcium hydroxide at high alkaline levels and dry the protein” So could a non pH/pOH molecule like a carbonium ion, a methyl ion, or an ammonium ion make a novel protein chemical, that possibly with enzymatic digestion becomes a beneficial drug; sort of like casein with ammonium makes a bunch of c=c-c=c peptides that have ammoniums on them, thus looking sort of like metformin, a biguanide with numerous c=c, That goes with preconcentration, predigestion protein sources with lots of gaunidine could produce metformin function-similars with ammonium ion (pNH3/pNH2) treatment. This could also be used on digests of the protein gluten.
At casein as well as gluten they could screen every n sized group of peptides available from a library of possible published custom digestions of the protein (producing like all 7 mers, all 40 mers etc) against activity databases to see if any of them are drugs, they could also massively parallel make molecular receptor attachment models of some amount of casein’s N possible truncated peptide constituents to find new drugs that could be made from casein or gluten.
Opiod peptide from digestion of milk: a 3 (H-Tyr-Pro-Phe-OH) ,4,5,6, or seven-amino peptide (H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH) like beta-casomorphin-7; perhaps some opiod peptides are actually enjoyable, which are also minimally harmful, perhaps from localizing at only particular brain regions like the nucleus accumbens; It is possible that nonCNS opiod peptides relieve discomfort without having cognitive or behavioral effects. I perceive just putting a hydrophilic lipophobic length of, or external hydrophilic or lipophobic tertiary structure outer layer of amino acids or a polyglycine length on a peptide will keep it on the body side of the blood brain barrier, so that could be a thing that relieves discomfort or could aslo provide anesthesia.
A map, possibly constructed with positron emission tomography, or other approaches, of a screened library of which peptides concentrate at what brain regions, as well as what body regions, and an immunocolorization map (or niftier technique) of peptide localization at each cytotype and tissue type would be beneficial to the creation of beneficial drugs, notably those producible from gluten digests and probiotics and gene therapy as well as possible germline modification. Nootropic: numeous nootropic peptides are described online and at the scientific literature, https://ultranootropic.com/ ,would vasopressin, thymosin beta 4, semax, noopept, as well as many other peptide variants that only localizes at the frontal lobes improve cognition and memory and other cognitive things without effecting emotional capability (limbic areas) or bodyside functions (cerebellum, brainstem)?
Noting CNS effects on longevity, screening all nootropic peptides to see if any of them are also longevity producing peptides could find new longevity drugs, as well as amino acid sequences that van be function mimiced with peptide mimetic drugs to produce completely new lifespan lengthening drugs.
also, “Casein peptides are used for high blood pressure, high cholesterol, anxiety, fatigue, epilepsy, intestinal disorders, cancer prevention, and stress reduction”
Could casein be used as an ion transporter to different cytotypes?
polyprotic acid, or a polyhydroxyl base
s from changing something like “sodium (salt of) Also, they can put anything, at perhaps 200 mg at liquid center gums like chewels.
Do any oligosaccharides (like sugar mini-polymers) have drug effects? Are any of them longevity or wellness effects like polyribose might have, polyribose molecularly sapced NR or NMN that turns to NMN at cytoplasm, as a possible enzymatic or some benefit to the brain as a food, or fostering beneficial probiotic growth,
Previously described are possible artificial colors that heighten wellness or longevity to be used as food additives. c=c-c=c-c=c structures are frequent at some colorizing chemicals. Also, a longevity version of bright yellow B vitamins could be possible.
Microsugar lancets like at applique needlesless drug delivery could have some activity at gum. That suggests a pack of gum could immunize against atherosclerosis, perhaps a dose per decade, or even a dose per century.
A month of gum chewing with highly localized, less than than mentally perceptible effects on feeling normal, senolytic could be a one month longevity treatment.
Although candy with immunoactive material at microlancets could also do immunizations, it is possible swallowing immunobeneficial or other longevity technology gum could be beneficial.
AEDG linked to carbohydrates; lithium linked to carbohydrates, ribose linked to AEDG could concentrate AEDG at the heart, providing benefit.
AEDG linked to lactate or lactic acid could concentrate at the brain, causing benefit; as a minute amount at food, gum, or candy, concentration of AEDG at the brain could provide benefit, notably though AEDG has something to do with pineal gland chemicals, so brain concentration could permit lower doses, be more likely to provide projected benefits, possible enhance or otherwise effect fertility (50% greater conception rate from melatonin at IVF)
NGF and BDNF heightening 2 amino acid peptide, noopept, “In animal studies, Noopept has been shown to stimulate the expression of two important cognition-related chemicals, Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).”
Could those two amino acids at noopept, proline glycine, or any other nootropic peptide, be used when attached to other drugs cause high utility brain localization, “Brain-Derived Neurotrophic Factor (BDNF) has a similar role to NGF but is primarily active in the hippocampus, cortex, and basal forebrain, areas of the brain that are vital to learning, memory, and higher thinking”, also, “readily crosses the blood-brain barrier”, so attaching 2 mer (prolyl glycine) noopept to 3 mer opiate peptide (Tyr-Pro-Phe) making 5 mer pro-gly-tyr-pro-phe as a brain concentrating opiate peptide?
Proline-glycine could be an effective way to get numerous other drugs to pass the blood brain barrier, perhaps phenibut-Pro-Gly could work at orders of magnitude less milligrams per dose, and it is also possibly Pro-Gly causes drugs to pass the ovary-blood barrier as well, improving fertility drugs and possibly making contraceptives even more affordable on a $/Kg manufacturing basis.
Protein Kinase RNA-Activated inhibitors, or PKR inhibitors like C16 are peptides described online as causing new path learning after one session as compared with several sessions for unmedicated mice; could PKRI be used to localize other drugs to the brain areas that cause the “one training session works as well as several” effect? CART peptide linked to PKRI is one possibility for a new nootropic that also makes learning with many fewer examples or less practice duration possible. Even linking Pro-Gly (noopept) which increases BDNF and NGF to PKRI like C16 could cause those rapid-learning neural areas to grow causing lasting increases in intelligence. PRKIProGly can be constructed and ordered online.
Are there any peptides that pass through cartilige and joint tissues rapidly, these are different than “blood brain barrier”, but if there is any preferential transport there might be peptide that does that at joints; chondrotoin, MSM, hyalonuric acid and others could all be linked to such a joint transport protein. This could also heighten migration of other drugs. This would treat or prevent some joint decay, causing more youthful joint form and usefulness.
Genetically engineering a plant that treats schizophrenia and psychosis: There could be a peptide, findable at a library of less than 576 two mer peptides that specifically effecs 5HT receptors, Latuda which functions only at HT2 receptors and is absent effect on D1,D2, orther dopamine receptors, causing fewer side effects, could perhaps have a functionalike peptide, and then the peptide engineered into plants, brewing yeast, yogurt, vaginal probiotics, and oral probiotics, making antipsychotic medication grwoable and able to reach more than 70 million people globally. Of the Pro-Gly two amino acid noopept, online it says, “Noopept modulates the activity of both AMPA and NDMA receptors”, so they could screen a combinatorial library of all the 2 unit peptide combinations of 24 different peptides, which is near 576 different peptides on 8 mice each, to get p<.05 at behavior change, like nonpsychotic begavior, and immunocolorization mapping of the brains and bodyside nerves to see which peptides caused localization at dopamine neurons, much the way Pro-Gly concentrates at AMPA and NMDA neurons. Also, as serotonin neurons have many published activities these serotonin active or also serotonin neuron localizing neurons could have numerous beneficial drug effects.
Although noopept Pro-Gly is functional at 10mg oral dose, could a leve-dextro version of the amino acids make it omit being digested, causing a nootropic doasge in the micrograms?
Similarly, could a levo-dextro version of opiate peptides omit being digested thus causing microgram functional dosages? Also, do opiate peptides work more enjoyably if snorted or vaginally applied, or made to be a buccal absorption alginate gel mouth coating?
A variety of ribosomal activity nootropics that might, or might not function like PKRI C16, Protein Kinase RNA-Activated Inhibitors,“What makes PKR inhibitors an EXTREME example is how it works. It essentially disables a security feature of the brain that helps to prevent viral infections” suggests the possibility that either genetic material reaching ribosomes omits a prescreening of some kind, or that the ribosomes work more rapidly, or that tRNA availability goes up,
Longevity technology: Dastinib with querectin are Senolytics that benefit the brain:
The senolytic: is described as, “Senolytic treatment of AD mice selectively removed senescent cells from the plaque environment, reduced neuroinflammation, lessened Aβ load, and ameliorated cognitive deficits. Our findings suggest a role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD, and a potential therapeutic benefit of senolytic treatments. “dasatinib and quercetin (D + Q), can selectively eliminate senescent cells from pathological tissues”
At mice, the senolytic dose was 12 mg/Kg of dasatinib and 50 mg/Kg querecetin, oral gavage with PEG/saline vehicle; so perhaps 70 mg per day of D for a human, utilizing the 1/12 mouse dose thing, and 350 mg of querecetin per day. Dasatinib is prescribed for 12 months or possibly longer as an anti-cancer drug, but the senolytic dosage duration at the mouse experiment is 9-10 days. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605052/
Dasatinib causes mice on an 11 week long dose to be better at learning motion pathways, at (youngish) 3.5 month old mice, rigged to be messed up, “In peripheral organs, partial elimination of senescent cells (~30%) is sufficient to restore tissue homeostasis and function in disease models and during aging7,29,30. We next determined whether longterm intermittent senolytic treatment could ameliorate Aβ plaque pathology and/or improve cognition in APP/PS1 mice. Beginning at 3.5 months of age, female APP/PS1 AD mice were treated with either D + Q or vehicle once weekly for 11 weeks (Fig. 5a). Hippocampus-dependent spatial learning and memory were evaluated by testing the mice in the Y maze immediately before, and at the 6- and 11-week treatment time points, and mice were also tested in the water maze during treatment week 10. Mice were euthanized at 11 weeks and their brains processed for biochemical (one hemisphere) and histological (the other hemisphere) analyses. [and then it says] Compared with vehicle-treated APP/PS1 AD mice, APP/ PS1 AD mice treated with D + Q performed significantly better in the Y maze at both the 6- and the 11-week time points (Fig. 5f). In the water maze tests, D + Q treatment enhanced memory acquisition (more rapid learning of the location of the hidden platform) and memory retention in the probe trial” Notably at a graphic at the paper, dasatinib with querecetin caused large but then identical learning effects; at day 4 of cumulatively learning a pathway finding task the drugged mice were approximately 62% better learners, but at day 5 they were identical.
At a different paper, “senolytic therapies could be administered intermittently, serving to reduce the senescent cell burden by treating quarterly or even annually, which minimizes the risk of side effects”, “Treatment of mice with dasatinib plus quercetin (D + Q) improves cardiac ejection fraction and increases vascular reactivity in old mice after a single, 3 day treatment course [30,34]. In addition, D + Q treatment decreases vascular calcification and increases vascular reactivity in hypercholesterolemic, high fat diet fed ApoE−/− mice after three monthly 3 day treatment courses”
They could see if a different chemotherapeutic drug, nilotinib, that works on the same kind of cancer as dastinib is a beneficial senolytic, possibly with nonoverlapping activity at different body cytes or body tissues.
Localization peptides or proteins attached to senolytics like dasatinib could cause even greater benefit. Pro-Gly could cause brain concentration, noting that dasatinib is published as heightening learning ability it is perhaps beneficial to have a senolytic reach the brain. Chondrotoin or MSM molecular moeity on senolytics could cause greater joint youthfulness function, reduce immunoreactivity and sequelae; the cytotypes senolytics remove are published as linked to bone-joint illness, suggesting senolytics could produce younger phenotype function at bones and joints.
Fisetin is a senolytic, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ “The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit.” as well as, “chronic administration of fisetin to wild-type mice late in life improved tissue homeostasis, suppressed age-related pathology, and extended median and maximum lifespan”, “This result, similar to a recent report on the combination of D ± Q, is the first to document extension of both health span and lifespan by a senolytic with few side effects, even though administration was started late in life.”,
Dose: “mice were fed Teklad 2020 chow (Envigo, Madison, WI) prepared with or without 500 ppm (500 mg/kg) of fisetin (Indofine Chemical Co., Hillsborough, NJ) by Envigo. Co. (Tampa, FL). For oral administration of fisetin, mice were dosed with 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10% ethanol or vehicle only by gavage.” That represents 7 grams of fisetin every 24 hours at a direct, non compensated for mouse size dose, or 583.3 mg every 24 hours at a compensated mouse dose. At the fisetin placed at food, “diet with or without supplementation with 500 ppm (500 mg/kg) of fisetin, ad libitum (approximately 60 mg/kg fisetin per day). The mice were exposed to a fisetin diet intermittently from 6 to 8 then 12–14 wks of age” which could be communicating that each Kg of mouse (that is a lot of mice) got 60 mg of fisetin, so 4.2 grams per day, without mouse division number, or 350 mg per day at the mouse dose equivalent convention number. On ebay, fisetin is $22 for 10g.
At the paper, 20 micromolar fisetin has twice the cytonumber reduction as 5 micromolar fisetin at cultured cytes treated for 48 hours, and the difference in messed up cytes goes from no effect at absence of drug to 1.1/.5, or about 55% reduction of messed up cytes at 20 micromolar.
A different graph displays fisetin at cultured cytes’ senolytic activity as 1.3/.4 or 69% reduction in senolytic cytes.
They measured the senolytic activity of 11 different chemicals, fisetin at 69% was more effective than curcurmin as a senolytic at about 50% https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/
It is possible that sequential or simulataneous senolytics could benefit survival and promotion of youthful cytotypes, so curcurmin with fisetin, or at a sequence with each other could be beneficial. Taking them simultaneously could possibly work better as it is possible the nonoptimal cytes express immunoattractants while processing senolytics, and doubling the amount of immunoattractants or simultaneously producing different kinds of immunoattractants could cause greater immune response that removes nonoptimal cytes.
Notable for fisetin in food compared with once a day oral dosing, fisetin has a plasma half life, so keeping plasma levels high and steady could be beneficial as the food only had 350 mg in it, compared with the 583 mg in the once daily dose, I do not know if they had identical senolytic activity yet though.
If a human eats .5Kg of carbohydrates that is 2000 calories, and at mouse dose would have 250 mg of senolytic fisetin, suggesting the 583.3 mg a day dose is better, noting at cultured cytes doubling fisetin concentration doubled senolytic acivity. also, at a different paper dasatinib was more effective at higher doses.
An immunization could have one of the effects of senolytics, “Senescent cells can develop a senescence-associated secretory phenotype (SASP), consisting of pro-inflammatory cytokines, chemokines, and extracellular matrix-degrading proteins”, immunizing against extracellular matrix-degrading proteins could cause greater tissue functionality longer, and senolytics are researched as causing greater wellness and younger phenotype. extracellular material might be particularly reachable with antibodies. It is possible that as some immunizations last as long as a person, immunizing against extracellular matrix degrading proteins could be a one dose lifespan increasing and wellness increasing immunization, possibly functional at farther than postpubertal ages even when given to a child, during the period when people routinely get immunizations and parents highly prioritize immunization activities and coverage. It is also possible that “matrix degrading proteins” have an effect on dermal cytes and structure, which I perceive I read have something to do with the word “matrix proteins”, that causes this possible longevity wellness immunization to also be a beautification and youthful appearance sustaining possibly one dose treatment, heightening popularity and voluntary use. The other chemicals mentioned, “pro-inflammatory cytokines, chemokines” could also be immunized against to benefit longevity, wellness, and phenotypic youthfulness; I pereive there are a number of these cytokines and chemokines, so a list of which have the highest mass/volume concentration both at the circulatory system and outside, right next to the cytomembrane at the intracyte space, and then immunizing against those, could concentrate effectiveness although cytotype and tissue specificity could make immunizing against all of them notably more effective; One benefit of immunizing against a multi digit (2 digit? three digit?) number of chemokines and cytokines is that some of them may have multidecade effective immunization coverage while others might have different immunization coverage, This partial yet long duration removal of deleterious cytokines and chemokines and matrix protein harming chemicals could actually interrupt and derail any harmful processes where the deletarious cytokines, chemokines and matrix-messing up chemicals effect each other, build on each other, or saturate body repairs, from combining or cascading each other’s effects. A person that is good at math and algorithms could look at a biochemical network, then come up with a minimum number of items to remove, at certain chemical-link distance from each other, to break a network effect, cause a different group average, or modify the persistence of an emergent effect, sort of like whats the fewest steps to wipe out a deleterious eignevalue? Immunizing against that group of chemokines, cytokines or matrix-protein messer-uppers could do that math, causing greater longevity, wellness, healthspan, and youthfulness of phenotype.
Protein or peptide linked drugs could traverse vascular plaque cytopiles to deliver beneficial drugs that shrink of remove vascular plaque blobs and cytopiles and be a cardiovascular wellness drug, “[senolytic]reduces senescent cell-like, intimal foam cell/macrophages in vascular plaques”; they could screen the 526 peptide library of 2 unit (mer) peptides formed from 24 amino acids to find out if any cause preferential traversal of atherosclerotic plaque cytopiles and possibly cholesterol coatings. lipophilic peptides could be better at traversing cholesterol coated or layered cytopiles. lipophilic peptides linked to physiologically harmless immunocyte attractants could cause macrophages and WBCs to find atherosclerotic plaque particularly attractive to glom and remove. Making a protein digest of bacterial cytowalls, then linking them to lipophilic peptides could cause the immune system’s rapid and effective response to bacteria to be directed at atherosclerotic plaque, causing greater wellness and possibly improving cognition with improved CNS circulation, as well as reducing risk of cardiovascular disease. Immunizing against cholesterol works on rabbits to reduce cardiovascular nonoptimality, immunizing against plaque blobs could remove them: also just as there are many different velocities and “brush strokes” to cleaning off a nonbiological item, different velocities of immunoresponse as well as different biochemicals to remove (immunoglom) first could be tested to find the immunocleanup of vascular plaque blobs that was most beneficial and with the least risk.
a novel senolytic mechanism with a “pick preferred candy out of a pile before getting on a school bus” metaphor: Some chemical transport channels of the exteriors of cytomembranes are possibly durably pluggable with molecules, these molecules are also consructed to have a lengthy molecular tail that the immune system recognizes and is reactive to. It is possible that deleterious cytes like the kind senolytics remove, as well as scar or encapsulation tissue cytes, as well as piled up cytoblobs at vascular arterial plaques, have greater molecular transport of some specific chemical. Then, I perceive that when a person gets a harmless viral cold, that they get symptoms for 3 days before the symptoms get better, that suggests that a 2019 AD human’s immunse system takes 72 hours to produce the antibodies to remove an infection.
Labelling many things, then using a gentle wash to provide unwell/well cytocontrast: Decorative plugs that occupy a transport channel at the cytomembrane diffuse away, with a half-diffused amount at 24 hours, so 96 hours after the labelling dose, only 1/8 as many decorated plugs are on cytes. If the deleterious cytes stared with 80 plugs per cyte they will still have 10, but the cytes that only had 6-8 decorater plugs will have about 1 or zero.
Noting that senolytics increase longevity, wellness, healthspan, and cause younger cytophenotype and tissue phenotype: a new kind of senolytic: Have the person eat or be dosed with an immunoreactive chemical that has a cytomembrane molecular transport channel plug that is like 3 to 40 times more likely to plug up a molecular transport channel at the external cytomembrane and accumulate at a deleterious cyte like the kind of cytes senolytics terminate. Noting well cytes and deleterious cytes differ as to their transport channels (senolytics are previously published as reaching their goals preferentially) Give them a big enough dose so that each deleterious cyte gets say 80 antibody-reactive plugs for every 2 at a well cyte, or even 90 antibody reactive plugs at a deleterious cyte for every 30 at a well cyte. Then give the human a big dose of the decoration (the antigen without the plug part) to activate the immune response, doing this after 96 hours of gentle diffusion washing away some of the decorator plugs, the big dose of plugless decoration causes a large immunogen response, after most of the well cytes are absent decoration while the deleterious cytes are still immunoreactive.
Also, along with the activation dose of decorator (absent plug) antigen to produce an immune response after well cytes immunoreactivity is decreased, It is possible to use the body’s apparently ordinary 2019 AD 72 hours to make an immune response to a viral cold effect, then have that 72 hour spontaneous immune response glom to and remove the decorative plug labelled cytes once 96 hours have progressed, the body has produced antibodies after the 72 hour viral cold-like process, and well cytes have only zero to perhaps 3 decorated plugs compared with 8 at a deleterious cyte. The deleterious cytes have been senolytically removed, and could even possibly be removed on a “senescent cytes have different transport channels” basis, the thing that makes it a new senolytic is that it terminates cytes like a senolytic without an external drug toxin; similarly this could be a way to treat cancer, removing some of the oncocytes. Noting that some mechanism at senolytic chemotherapeutic drugs like dasatinib get preferential effect (thus likely membrane transport) at senescent cytes, and then the senolytic drugs terminate the senescent cytes, it is scientifically sensible to think senescent cytes have different molecular transport channels, or quantities of ordinary channels.
Plugging the transport channel while attracting immunoreaction, when the immunoreaction can be times or sequenced creates kind of algorithmic numerical advantage in removing deleterious cytes. Possibly a plug that resides for just hours or 96 hours would preferentially remove deleterious cytes while using up all the circulating beginning antibodies to the decorated plugs; The decorator-plug immunoreactive cytes can use up all the circulating antibodies, that lack of antibodies causes the immunoreactions effect on well tissue to be minimized, which maintains organism well being. At some numerical versions, noting each deleterious cyte has more than 8 times as many decorative plugs on it while the well tissue only has between zero and 1/8th the sites and immunoreaction, After 8-24 hours after the 72 hours before the body makes its own antibodies to the plugs, at that 96 hour chronoregion, all the existing amounts of anti-plug antibodies are utilized and there are near zero circulating antibodies, so there is an absence of further antibody glomming action on well cytes and tissues even though the immune system has been activated, activated with the same effective intensity as a response to a viral cold.
So like 100 milligram of antibodies gets used up on the highly 8:1 decorated transport channel-blocking molecules, while well cytes have a graphical distribution displaying the number of glommable plugs as centering on just one or even zero; It would take 24 hours to make another entire 100 milligrams of antibodies, so noting the decorated plug molecules wear off before that 24 hours while the body is producing the next 100 mg, the 24 hours that pass make cause just 1/4 of 1/8th the decorative plugs to be at well cytes. The well cytes only get 1/32nd the immunoreaction cleaning dose of immune system response. Meanwhile the deleterious cytes still have a plurality of decorative plugs at each cyte, labelling them for glomming and removal.
Longevity technology:
So is there a sequencable series of natural allergens, or even easy to find and get harmless colds that can be screened, like a screenable library, to do this glom at the places beneficial senolytics are active, gently wash well cytes to experience immunoharmlessness, and also up immunocytes purposefully to terminate the labelled deleterious cytes? That would be a sequence made from preexisting viruses and allergens at the 2019 AD typical population, where a human body proceeding through that sequence actually gets greater longevity, wellness, healthspan, and youthful phenotype.
So, uh, BCG, and possibly, MAO-B receptors on blood cyte surfaces, and perhaps there is something natural that occurs at capillary epithelial cytes; could blenderized pollen, perhaps with oil to make GI tract passaging liposomes, cause immunoreaction at the circulatory system? Also what about things like mushrooms, fugu, and other species immunoreaction physiological products? Are there things like blenderized e. coli variations of particular kinds that cause varied immune response, which can be bred or engineered to be longevity, healthspan, wellnes,, and youthfulness of phenotype beneficial senolytics, because they have different lipopolysaccharides on their membranes?
Find the receptors or molecule transport channels that are at the exterior cytomembrane of senescent cytes, the kind longevity, wellness, healthspan and youthful phenotype producing senolytics effect. Optimally find external cytomembrane molecular biology characteristic structures, senescent cyte-only receptors and molecule transport channels unique to senescent cytes. Then gather a bunch of those unique molecular biology object-features, like proteins, molecule transport channel membrane protein structures, or possibly lipid raft like cytomembrane fragments with a stable, typical to living structures of a molecular biological form of the kind of deleterious cyte terminating senolytics terminate, Then screen libraries of wild-type bacteria, fungi, plants, and even virus products to find out if they effect, modify, block, cause hypertransport at, or disintegrate these molecular biology structures.
Also, a novel thing, place a bunch of the actual molecules and proteins that are the unique biomolecular structures of the kinds of cytes senolytics terminate, at a culture medium, perhaps a (1000 times 1000) million multiwell plate, that contains a wide survey of bacteria, wild yeast, and variations on what humans think of as beneficial bacteria (probiotics); possibly use micropositioning to place a zone of molecular biology unique structures, a diffusion gap. and then a bacterial growth area: this causes material that diffuses across the zone to be measurable as to its quantitative effect on the unique molecular biological structures of the kind of cytes senolytics direct their effects at; When some of the million sample multiwell plates find bacteria, fungi, even viruses hosted by human tissue culture cytes products’ or other materials that cause plugging, blocking, hypertransport amplification, or disintegration of the unique molecular biological structures of the kind of cytes senolytics terminate, then organisms that produce new senolytics have been identified and can be quantified as longevity, wellness, healthspan, and youthful phenotype producing drugs. These wild type organisms can also be bred to have much higher amounts of senolytic chemicals. That is a new source of senolytic drugs.
As a technology, an immune response generating functions-like-a-senolytic yeast beverage or yogurt, plant, or plant pollen, bscteria, or even physiologically and attentionally nonperceptible dermal bacteria, similar to a probiotic, that is a senolytic from immunofunctioning, that is the immunosensitizing bacteria, plant, fungi or even virus causes greater longevity, wellness, healthspan, and youthfulness of phenotype like senolytics do. The humans, that is person’s or people’s immune response to optimally, the organisms or ok, but less nifty as it goes with actual human sustained production of concentrates, organism material concentrates, where both and either of these causes the immune system to be sensitized to glom and terminate the kind of cytes senolytics terminate.
So, perhaps: blenderized e coli membranes, combined with cytomembrane molecule transport channel plugs that preferentially populate deleterious chemokine and deletarious cytokine export channel (efflux) transport channels, also combined with some oil to make liposomes that make it through the GI tract;
So where do the at-wild, at 2019AD society, efflux blocker molecules come from? Organisms at a culture medium with chemical travel zone and an area of chemically changeable molecular biology structures to measure the modification efficacy of each of the organisms forms is described. As another source of efflux channel blocking molecules that are combinable with immunosensitizing decorations on the efflux blocking molecule, for immunoglomming and removal, which has a senolytic function effect.
It seems like it would be possible to screen a library of naturally occuring materials and molecules,proteins, peptides,andother things, as well as genetically engineered materials like new or enhanced proteins and peptides, to find out if there are any that plug the efflux channels that are effluxing deleterious biochemicals.
It might be that to a molecular biologist this is sort of easy, like “the transport channel is n angstroms wide and w angstroms tall. Anything hydrophobic/hydrophilic you make with an angle bend, a beta sheet or an alpha helix on it will block the efflux channel of that size and form. If you make a 20 amino acid peptide tail and put iton the plugging protein, you can use an amino acid that is absent any environemental or body-wide previous immune sytem antigen stimulation, or immune system activity. Immunocytes that react to the unique 20 mer peptide, after the “immune system alerting dose” are unlikely to react to any other physiological biochemical, minimizing immunological reactions drift, thus keepin nearer optimal human, immunofunction, human longevity, human wellness, and youthful phenotype form at the human.
The technology is that if just those cytes are immunoterminated which have a bunch of efflux channels where deleterious cytokines, chemokines, and matrix protein messer-uppers are effluxed, then that immunotermination functions like a senolytic:
Gene therapy, that transfects and terminates deleterious cytes with something like apoptosis, gene therapy that produces immunoequivalents to senolytic drugs, or gene therapy that actually produces proteins or peptides that are senolytic in their own right. Technology of senolytic longevity, wellness, healthspan, and phenotypic youthfulness of form are developing. At 2019 AD, at any deleterious cyte where a senolytic accumulates at but previously did not terminate as it would more optimally do, gene therapy could be a way to get the 30% that fisetin does not reach, the 50% that curcurmin does not reach, or the numerous kinds of cytotypes and tissues that any known senolytic might not reach the cytoplasm of (cartilidge, eye lenses, osteocytes, other nonvascularized tissues).
Curcurmin and fisetin are published senolytics; could curcurmin as well as fisetin molecules with an antibody alerting moeity or tail, attached with: an enzyme endogenous to the cytoplasm that divides the curcurmin or fisetin from the immune system alerting moeity, which then travels to the outer surface of the exterior cytomembrane, which alerts the immune system to terminate the cyte that the senolytic has already localized and concentrated at. That only works if fisetin, curcurmin, andother senolytics actually localize to deleterious cytes. If they just go to allcytes, but only terminate deleterious ones, then a different technology would be the thing to make. If senolytics do localize and concentrate at deleterious cytes then putting immunoactivators on them would cause them to be even more senolytic as the immunocytes seek them out.
wellness technology: somehow leukocytes, macrophages and WBCs notice they are more effective at being an active and beneficial immune system when they travel past the capillary epithelia to actual cytotypes that provide a utility definition to a tissue (chondrocytes, pneumocytes, cardiocytes, dermatocytes, beneficial only immune responses to neurons, glia, mesentary, hepatocytes) to have a curative beneficial effect; that is they make their way past the epithelia to reach pneumocytes to engulf pneumocytes that have viruses and cure pneumonia when they do that. So, is there a chemical peptide or protein that causes luekocyctes and other immunocytes to move past, or between, epithelial cytes twice as often, twice as fast, or even travel preferntially along tissue cytes and omit a travel path that is along epithelial lined passgaeways like capillaries? Those would be drugs that multiply the effectiveness of the immune system at interacting with and vanquishing infections. Kindof like the utility of antibiotics, it could be possible to terminate twice as many infected cytes orinvasive organismsevery 24 hours, rapidifying recovery from illness and improving wellbeing.
screenalibrary,
lookfor variants at a human population, find the genetics of passing epthelia or omitting travel at epithelial separation from the tissue cytes to be beneficially immunoterminated. Gene therapy could then produce muchhigher effectiveness immune systems at the people whoget the genetherapy who then have immune function that is twice as effective as passing, or passes twice as frequetly throughepithelia. Similarly my perceptionisthe leukocytes WBCs and other immunocytes have chemoreceptors. it is possible that at humans some human immune systems have twice the ability to sense, accurately a immunomeaningful chemical or molecule; These might be much more effective at sensing things at a distance when to pass an epithelial structure like a capillary to reach an actual tissue cyte to terminate the deleterious cytes and cause healing. One thing supporting the twice as effective idea is that at other body systems human capability differences between and amongst 2019 AD humans ranges over amounts much more than twice as effective, human vision, from 20-15 to 20-30, at immunoreactivity, children and adults have notably different immune learning libraries, much more than two times different, even persons of normal mental capability during 2019 AD could have brains that were twice or half as weighty. The technology is then, find an area of the immune system, particularly rapid, affordable, and effective at being changed, where the difference betweena human withthe most beneficial versionand a median activity humanis twice the effectiveness or greater. Then amongst that list of doubled or higher immune system capability, find the capabilities that respond withgreater ability most effectively to drugs, plants or other organisms, gene therapy, germline modification, lifestyle changes, and
Possibly things like biologically originated duration of immunity from an exposure could cause some people to be ill half as often (twice effectiveness) at areas, mostly previous to the 21st century, where disease organisms were persistent at the environment. So these persons would be able to omit becoming ill twice a as long or twice as effectively as others when re-exposed.
Adjuvants. I read about vaccine adjuvants. Are there any physiologically harmless adjuvants, possibly what were known during 2019 AD as GRAS food additives? Adjuvants similar to those that are a part of vaccines; these adjuvants when taken orally cause the entire volume of the body to be more effective at beneficially developing an immune response. So basically, if a person gets athlete’s foot, taking an oral adjuvant makes them twice as effective at developing an effective immune response to the fungi, so that makes them be cured twice as fast and be half as likely to have a recurrence. It is possible a bodywide adjuvant could reduce pneumonia, saving lives, although infection frequency could just be from organism variety; also, there is research on food, lifestyle, and cancer prevention. I have not heard of how taking adjuvant pills could make it so non detectable carcinogenesis is twice as immuno reacted to, thus the persons as a population, as measured at a population, get cancer as disease half as often.
Wikipedia mentions PAMPS, “Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA.[4] Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells (DCs), lymphocytes, and macrophages by mimicking a natural infection.” things that look like cytostructures, a lot of different things have as adjuvants.”, screening large libraries of PAMPS could find better adjuvants and possibly those that if taken orally, possibly as parts of liposomes, provide beneficial systemic immune sytem enhancement.
It is possible to imagine liposomes, or artificial lipid bilayer bags, that have proteins on their surfaces causing engineerable changes in immune response, that is, being adjuvants;
Bag surface proteins could be kind of purposefully noncomplex, priming for a broad different similar group of proteins to recognize. Noting the lipid bilayer bag could be made out of different lipids it is possible lipid bags made out of really lengthy new omega 3s like C20 or C27 could be hyperdurable yet physiologically harmless or even measurably beneficial as omega-3s when they disintegrate. My perception is that some kinds of liposomes are ultraffordable to produce, sort of like: oil, water, ultrasonic transducer manufacturing.
They could screen a library of mlecules to find out if there are better adjuvants than “alum”, aluminum phosphate. Gallium is at the same row of the periodic table so they could try that. Also, noting the milligrams or possibly even micrograms of aluminum phosphate at an injection it is possible aluminum phosophate liposomes that make it past the GI tract could produce the same chemical concentration as an injected dose from oral consumption; it could have its flavor made palatable rather than tasting like alum because of the liposomes.
Also, they could find out if oral food: pickles, which contain alum, have an immunobeneficial, all-body adjuvant effect on laboratory mammals, and also do correlation studies on humans that eat pickles. It is possible there are other adjuvant foods, possibly some kind of recipe for liposomal transport of something immunoadjuvantish, so like a salad dressing, a nugget dipping sauce, a dilute milk drink, or a new kind of quantifiably physiologically beneficial margarine to make liposomes or lipid bilayer bags with and at. There is a chance that oil coated fried potatos like french fries could have a liposome producing oil-water effect, or a purposeful coating; the technology to think of though is what is at the core of the liposomal bag; PAMPS; something like “vegemite”, dried yogurt powder enzyme product (basically a bunch of bacterial cytostructures and mambranes as a heap of legos), I read activated carbon, and I think zeolite like aluminum oxide, so possibly some naturally occuring zeolite like mineral, at liposomal bags. They could also make artificial zeolite that is, imaginably many times more effective than other forms of aluminum oxide, although it might not be.
If zeolites work as adjuvants, then a variation of the food thing sodium silico aluminate might be sort of like a ceramic material that could have a different zeolite like form that could be an adjuvant.
silica gel adjuvants: Other silica materials that might have adjuvant character, be placeable at liposomes, or could have an adjuvant like aluminum or gallium phosphate or ion exchange resins dissolved in them are silica gels, it is possible silica gels have different AMU amounts of silica networks, so perhaps they have light and medium ones, ones that adsorb strongly, others that adsorb weakly, also, silica gels can absorb liquids which I perceive might diffuse out again over hours, so if there is a liquid adjuvant it might go well with silica gel with liposomal bag around it; “The hydroxy (OH) groups on the surface of silica can be functionalized to afford specialty silica gels that exhibit unique stationary phase parameters. These so-called functionalized silica gels are also used in organic synthesis and purification as insoluble reagents and scavengers.” makes custom silica gels sound like they can be tuned to absorb or adsorb custom chemicals, there is even a chance that they could do some sort of simple localization, although it seems like to a silica gel, everything they are near would be epithelium.
Another, new to me approach to an oral immunization: If silica gels that are really eentsy are placed in liposomes then migrate through the small intestine to the circulatory sytem then perhaps they meet immunocytes like leukocytes or macrophages or WBCs or some other thing that react to them as a granular particle to be engulfed, I do not know how it works, but after being engulfed a silica gel particle might diffuse out something, even a liquid, that then causes a beneficial immune reaction.
Alginate jello blobs at liposomes might be an adjuvant, “adjuvants may provide physical protection to antigens which grants the antigen a prolonged delivery” That suggests the possibility that putting alginate jello in liposomes would cause alginate filled oil-water bags to travel around the circulatory system. These might pruprosefully leak alginate, causing some amount of antigens to get alginated-attached and then get gradually re-emitted; also ion exchange resins could be at liposomal bags and even glom and then gradually re-emit biological molecules of particular masses and surface charges.
Somewhat dubious, but it is my perception there are sometimes trace amounts of blood in stools. That suggests that an adjuvant, like a PAMP, aluminum or gallium phosphate at liposomes, that dissolves or migrates through membranes at the large intestine, or just contacts the sides of the large intestine, which, based on the blood at a stool concept, might have circulatory system distribution possibilities for something like the micrograms or milligrams of something like alum that could be a bodywide adjuvant.
longevity technology:
Gene therapy technology:
It seems like a dermal dose of thioglycolate based hair remover cream that, at more minutes of activity than I think the 2019 label suggests, causes moist plasma-like exudate would be an effective, simple to dose (just calculate cm^2 dermal area to topically dose to get a particular number of milligrams or micrograms of gene product per 24 hours) gene therapy technology, then to produce even greater effectiveness, have the gene therapy modified dermis have an optically activated activateable gene or gene therapy promotor area that would make it so that you could further program and direct the dosage with laser (like blue laser pointer) activation or the application of a highly available chemical. Among these technology methods is having dermal gene therapy respond to topical materials, many of which could be available almost without effort, for example, topical tannin, which could come from a leaf poultice available anywhere there are leaves, or a pharmacy, as the person prefers, could activate all, or just a little part, or even just an easy to remember location (poultice on your elbow once a month or once a year to omit ageing) dermal gene therapy area that causes some particular healing or also wellness response, as well as a longevity increasing, healthspan increasing, youthspan increasing, and lifespan increasing chemical, or as another item, produce a voluntary behavior enhancing chemical, a mental wellness drug, a cardiovascular well being drug, a senolytic, as well as a cognitive preserving and cognitive enhancing drug, an general immunoactivating drug that causes the production of more of the immunochemicals or immunocytes that are the first to notice something like a nonenutral nonbeneficial organism at the body, and, as the research finds effective treatments, an anti-alheimers protein drug; along with those technologies listed and described new better drugs that are thought of, found, and made into dermally available, light or chemically activateable gene therapy forms abe beneficial and creatable. Like I will see if I can think of a new one, if I can then that verifies humans, that is persons, that is people can invent new beneficial medicines. How about fMRI drugs? fMRI of a various thoughts and emotions that get the same verbal or writing or software measured, psychology test quantifgied description while having different fMRI data graphics, which is actually a form of algorithmic math representation, as well as positron emission tomography representation; These identically described but experientially more beneficial ways of a brain having being, isness, content, responsive ability, cognition, feeling, resting or active ambience would be different than they were before adjustable, beneficial, voluntary and even reversible or wears-off (recoverable) gene therapy; these cognitive ways, mental baselines, emotions, and even different than the thinker things like dreams or responses to media, to the extent that although they have differing fMRI or as well as positron emission tomography graphic and math measures they have identical measured quantifications at tests, computer tests, and even a person’s self-generated written descriptions of the experience of having a way of cognition, feeling, or awareness as written by the person. Math is used to define a data space, and the data space here is, with fMRI orpositron emission tomography visual feedback there is something you can prefer, and make actual with putting a leaf poultice or light ray on your arm to make durably the preferred optimized usual way to be, that can be reversed if you like, that is undetectable to prose, 2019 AD psychology measurements, the surveyed perception of other people, measurements of productivity of any kind, or computer neural network (such as deep-learning) predictions of your behavior. You like things better, feel better, think better, emote better, and do many other things better, but it is undetectable to others. When you activate the gene therapy area, such as a light or topical material activation of an area of dermis that gene therapy causes a shift to that version of genetics that causes the fMRI or positron emission tomography math and graphics to have software create the actual biological gene sequences, that will produce your, that is the utilizers, preferred version of the cognitive direction, ambience, and experience that is preferred. You can put some leaf poultice or shine a bright light on your elbow once a year to create your preferred form or kind of happy, your preferred kind of imaginative, and your preferred kind of productivity, orderliness or tidiness. It is the “even more opposite than a P-zombie drug” that gives humans, that is persons, that is people, the ability to experience, prefer, and activate benefits which are language, AI (without digital tomography), behavioral, productivity form and amount, as well as psychologically surveyably really unlikely to be discernable or distiguishable, although of course fMRI or positron emission tomography of 3d (4d time) maps of neurotransmitter locations and activation is mathematically and scientifically modellable, predictable, and the source of new materials, ideas, content, and applications with math and science. It is just nifty to be able to make actual a preference of being, isness, response to things, mental forms, nonself-forms like dreams, as well as other attributes that are among the beneficial, all of these while, being absent the possibility of verbal, written, or nonmathematical description. This gene therapy is a way to be the thing, the more womderful optimal thing, you could not ever describe, after sampling it, and being able to reverse your activation of the newly optimized way of being. Also, as an amazing feature, any human, that is person, or people, that modified themselves this way would, with very high likeliness of nondetectability, function exactly the same in the perceptions of others. You would feel creative and happy and productive, and even when between thoughts, feelings, as well as sensations prefer the newly optimized form at the new way you prefer, yet those around you would be absent noticing any change. Along with beneficial, nearer to being a preferred optimal, change that is outside of description and discernability to others, the person, that is human, or people would like to they can also get voluntary, voluntarily durable, voluntarily reversible, gene therapy that causes perceptible beneficially experienced personal voluntary change that other people can perceive if that person, human, or people feel like it.
Is there any beneficial protein or amino acid that if gene therapy produced at the optical areas or whites of the eye would benefit human beings? I read that cataracts are treatable with some eyedrops made from an amino acid, it is possible gene therapy with one dose of instilled fluid could prevent cataracts or provide a one dose cure for cataracts when it causes the production of the cataract curing amino acid. it is even possible that halving or quartering the immunoreactivity of corneas and lenses using gene therapy would make them stay clearer longer with less surface variation. AEDG and the thymulin peptide combined make humans 4 times more likely to be alive after a 6 year interval, so an eye instilled gene therapy fluid that causes the eyes to make AEDG and thymulin could possibly be a one dose longevity, wellness existence preserving functional activity drug.