All the ideas I put online are public domain ideas. Actually all my ideas are public domain ideas. Treon Verdery, March 23-31, 2019

Most of the written material is about new to me technology to benefit human beings.

Plant growth encouraging shapes:

It is possible that ambient warmth causes crops at some locations to grow faster; although locations differ some places with light wind could have faster growing crops if tempory windbreaks, possibly like flaggy posts were automatically placed with agricultural machinery during planting; something like a tractor that puts up temporary posts with flags or flaps on them. There is even a chance that an aerodynamic shape that produces an anti-coanda effect air shape or coanda air curtain that blows transverse to wind could slow or diffuse winds and breezes from just blowing past a stake or post. It is kind of fun to think of an angle reflector coanda effect air curtain at 90 degrees to the breeze powered with the wind itself.

The flaggy parts on the posts could be white to reflect more light onto the plants, yet could also be coated with transparent IR absorber to warm the plants and air. Narrow space reaching drones could pull them up and out as the growing season warms.

Companion cropping, which might sometimes be called polycropping, plans or sows and grows two or more crops at once to heighten yield and/or nutrition of at least one of the crops. Are there dwarf seedless versions of some companion plants that benefit other more important crops; example, dwarf low-height, stakeless/trellisless seedless beans that improve corn more than 10%? There could be new varieties of (possibly antiweed/anti-insect) mini-plants that could be developed.

Are some plants better at making organic mineral molecules, possibly among many chemical possibilities, organic phosphates instead of PO4- so that the plants they are next to experience better nutrient absorption from? These could be mini-companion planting crops that benefit the plants they are next to. Possible application of nutrient remolecularizing companion crops at things like no-till agrciulture, as the new better absorbed chemicals leach out over the year from the no-till cover debris.

Omit this bracketed text as research apparently refutes it: [[“Pigweed raises nutrients from the subsoil to where the corn can reach them”]]

Pigweed might not work; pigweed planted with corn is published as lowering the amounts of NPKCaMg minerals 33-53% at the corn https://ucanr.edu/repository/fileaccess.cfm?article=161380&p=YXMICQ which sounds nonoptimal.

Weed control; I read that weeds at fertilized fields can reduce crop yield, even with added fertilizer. Technologies that reduce weeds benefit crop yield, notably at fertilized crops. Could drones with lasers that aim for the center veins on leaves use even less energy to laser zap weeds into cease growth.

Genetic engineering possibility: find a weed species, or engineer a new companion plant with just some of the things weeds might have been associated with during the 20th century AD like rapid growth and high fertility; The new companion plant, unlike weeds, is engineered and/or bred to raise rather than reduce crop yield, including at fetilized applications; then genetically engineer it to “raises nutrients up from subsoil”

Omit material written between brackets as the research does not support it[[(pigweed quote) to increase crop yield]]

New companion plant engineered tobe rapidly growing and fertile that increases main crop yield even while fertilizers encourage the growth of the new additional plant. The thing is that pigweed is actually published as lowering the soil nutrients available to corn so this idea might not have any actual utility, so I have placed it [[pigweed]] in brackets.

The engineering of a new companion planting plant that actually increases yields is beneficial.

I am too uniformed to highlight which companion plants might be better with other plants so omit these words on chamomile:[[Chamomile is described online as improving growth of some crops.]]

Perhaps a new variation on pigweed with a nicer name could be genetically engineered to raise 2-3x the nutrients up from soil as well as actually increasing crop yield and human beneficial nutritional content.

Do plants benefit from free amino acids in soil? Bacteria or fungi, possibly also at mycorhizzial communities/probiotics could make the free amino acids. At grazing lands or hay lands, it is possible that milk yield increases with free amino acids in soil that that build proteins at plants.

It is even possible that plants benefit from unusual carbohydrates free in soil. It is possible to imagine that potatoes might benefit from molecules very similar to to the starch they make and concentrate being at the soil and drawn up at the roots. Three carbon sugars like erythrose might have higher root membrane transpotrability than other carbohydrates and be producible at engineered and possibly mycorhizzial bacteria or fungi.

High lethality tiny mass insecticide: Previously described: Aptamers are one name for the part of antibodies that actually glom onto another molecule, tissue, or chemical; attach insecticides to apatamers to create new insecticides that concentrate the insecticide at particular insect tissues causing the insects to die with a smaller amount of insecticide consumed. Aptamer tissue concentration at tissue can be above a 10,000 times concentration at tissue, (my perception based on immunostaining effectiveness) That suggests 1/1000 to 1/10,000 of the physical mass of insecticide could be used to kill insects. Tissue and proteins particular to insects, notably to particular species of insects, could be the targets of the aptamer insecticides. Targeting particular species would minimize the lethality of these aptamer insecticides to things like bees. The bacteria used to produce the BT insecticide could be genetically modified with attaching the aptamer protein to the BT protein strongly increasing the concentration and activity of BT at killing the target species. Aptamer linked insect contraceptive proteins or peptides, or those that block the production of chitin, are another possible insect reduction technology.

Drip form-modified insecticides, possibly with glycol or other cheap organic chemical thickeners, might concentrate or bead up at leaf edges, increasing dose to insects, possibly at the leaf tissue areas they seem to prefer eating.

I read that something similar to ketaconozole is used as a fungicide at large nonhuman applications. Perhaps one ketaconozole use: agriculture. Could bacteria be engineered to produce a *conozole like ketakonozole, but perhaps without causing resistance to human medicines like ketaconozole even though it has mass application?

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A marbled-paper spray emulsion create a dot-halftone like pattern of insecticide on plant leaves; This could create dose hotspots where a much higher than usual dose of an insecticide is consumed, causing a poison spike effect at the insects physiology. An effective insecticide,even though the average amount of insecticide at the whole plant is the same as previous techniques or even a lower amount. The poison spike effect could make some things which are not currently insecticides because their LD/50 effect is too low to become functional insecticides because of the much higher poison spike dose. This could be an effective use of pesticide spraying drones that are good at getting really near a plant. I think marbled splatter-dots from a traditional sprayer would aslo work.

.5b

Botox-like muscle relaxant peptides (like they have on alibaba) could be insecticides, possibly relaxing the muscles at insect mouthparts or causing GI tract smooth muscle not to move, killing, starving, or removing motional transport (slackening limbs) at the insect. As peptides these amino acid sequences could be genetically engineered into crops or genetically engineered into mycorhizzial community bacteria or fungi to kill wormlike pests while producing minimal above-ground chemical or peptide concentrations. Also, possible application to silviculture as well as agriculture with trees producing muscle relaxant peptides at bark and sap.

Insecticide islands at trap crops: Drone small-area microapplication of insecticides to trap crops could raise crop yields. “Trap cropping is the planting of a trap crop to protect the main crop from a certain pest or several pests”. Drones flying around, spraying only the trap crops with insecticides could kill the insects. Also insecticides that have different plant approvals or time to wear-off before harvest times could be used at the small-area sprayed trap crops, increasing the number (product list) of different actual usable chemical insecticides and treatment options at crops that might have previously had a fewer number of approved or recommended insecticides. Trap crops are a kind of companion planting. The trap crops could even be bred/genetically engineered to have insecticide duration increasing leaves (doesn’t wash off from rain, less evaporative-prone surface, possibly white for higher solar reflectance).

Some aphids are clonal. It is my perception that clonal reproduction on an already infested plant increases the amount of aphids on that particular plant. I think it is possible to make a clonal contraceptive protein that affects only clonal insects; that would omit effects on other insects and be an on-plant sprayable that actually reduces the harm to one particular plant, as compared with an insecticide that poisons an insect, which dies eating a different plant than the consumed plant. The anti-clonal chemical could be a reproductive protein near-identical variant that blocks receptors, producing contraception and/or hormone blocking. This could be produced at a genetically engineered probiotic-like bacteria ot at the genome of the crop plant.

It is possible a contraceptive protein that works on insects, nonclonal and/or clonal, could be a “standalone plant rescue” saving things like individual trees from multigenerational insect pests that might harbor. There could be silvicultural as well as arboricultural applications. The protein or peptide or chemical could be a reproductive protein near-identical variant that nullifies physiologic activation from the native protein or peptide. This insecticide chemical that occupies or blocks receptors to producing contraception and/or hormone blocking

Drones could manipulate and plant at the small spaces between plants at co-cropping and/or intercropping. Wikipedia says, “The terms "undersowing" and "overseeding" both involve intercropping as a type of companion planting.”. The drones would place seeds between plants already partially grown that are near each other.

This peanuts and cereal technology is almost a [[bracketable]] technology to omit as I perceive the cereals would either shade the peanuts or the peanuts would shade the cereal. Perhaps it would be possible to try different ratios to find one that optimized calroie output or protein output per acre above that of a monocrop of either.

A person online says, “I could imagine peanuts as a companion for grains” Genetically engineering peanuts to be a better companion-planting crop could beneficial as the harvest is based on filtering dirt, rather than cutting and sorting top-of-plant crop mass.

Based on intercrop shading this is another possible to omit, near-bracketable idea that could benefit from actual research and total carbohydrate/food energy produced per acre: Sweet potato vines are mentioned online as an edible groundcover. It is possible cereals like wheat could companion-plant with genetically engineered sweet potatoes to produce more calories per acre; the sweet potatoes are a harvest with sifting dirt crop, thus have minimal or no effect on the harvest top-of-plant methods and yield of cereals. An easier application might be: is possible that sweet potato leaves, which I perceive to be high in animal-digestible nutrients could be a part of hay crops for milk producing mammals.

Would a protein or peptide that reduces or blocks chitin production at insects be a new effective insecticide? This would have zero effect at mammals like humans. This could be genetically engineered into the plant, be a spray, or possibly a probiotic.

.5b

Surface peptides and proteins that can endure wetting and weather to be active when eaten at an insect. Coat them with cellulose of a particular type highly digested at the insect GI tract. Another possibility is growing the peptide inside a virus capsid, so the capsid get/repels the weather, then at the insect mouth saliva or GI tract the capsid dissolves leaving the active protein or peptide. I imagine big vats of virus-bearing bacteria making the capsid-encapsulated insecticide. An advanced technology would be benign-to-the-bacteria virus infection where the virus has capsid coated protein insecticide in it; the bacteria would then be applied kind of like a probiotic or mycorhizzial community bacteria/fungi.

A cheap developing world insecticide could be multi-year durable for value effectiveness yet still harmless at human consumption; some really powerful protein, possibly an insect contraceptive or an aptamer insecticide or muscle relaxant peptide could make tiny amounts of windblown soil function as an insecticide at next years crop also a possibility is bt probiotic spray where the living probiotic community persists a few years.

No-till agriculture is used at Washington State, USA on wheat. At no-till agriculture wherever it is used, it is possible that genetically engineering things like plant stalks to contain an insecticide protein like BT or insect contraceptive proteins could make the standing biomass from the previous year an effective insecticide at the current year’s crops.

Weeding with drones; besides lasers, aside from cutting off a plant top drones could place a vertical needle in the stalk of the plant, perhaps penetrating to the linear root. The needle could be Herbicidal and biodegradable. A herbicidal sliver.

Perhaps an edible ground-cover could be used as a companion-planting plant. Online, sweet potato vines are menioned as a groundcover. As a food, sweet potatoes have some use.

Another edible ground cover: Drones could harvest strawberries which are kind of ground cover food plant. Perhaps a miniature version of the strawberry plant could be bred or genetically engineered to have fine narrower-diameter stalks, stems and runners and littler leaves with regular sized fruit. The eentsier size of plant parts could make it a better ground cover. At companion cropping the companion crops sometimes take up space preventing weeds from growing.

A recreational gardening drone or robot could benefit, stimulate the technology of, and/or benefit from agricultural drone technology. The drone or robot could prepare soil, weed and prune, and harvest crops and even decorative plant parts.

Improving cities:

Is green minipatterned minerals or pattern printing at grasscrete more aesthetically pleasant, thus more utilizable, than 20th century grasscrete?

on the internet it says, “I know lots of people who intentionally share their cars” perhaps something could be done with car sharing to improve well being and city living. Hitchhiker pick up zones at [gas or electrical vehicle charging] stations. Technology: the transit/car share stops could do biometrics identification on everyone who visited them, perhaps only letting people that were biometrically identifiable to use the transit stop to use the pick-up zone. That would possibly deter negative driver-rider interactions. The cheap quick now version could have the person just show ID to the camera to qualify.

.5b high occupancy vehicle lane improver: At some volume of cars or traffic density, shifting some people/cars from regular highway lanes to the high occupancy vehicle lane improves traffic for everyone, and could notably improve it for the those people actually newly travelling on the high occupancy vehicle lane. Improve this with the computer displays already at cars. A computer could do a stochastic lane assignment amongst interested drivers directing some to the high occupancy vehicle lane even if they were single drivers.

Activity: Is there a physical activity or topic that predictably maximizes positive reinforcement? It is amazing to me, but possible that athletics causes people to hear “nice catch” or “great run” more frequently and with a complete absence of detracting negative reinforcement statements. So a new sport or recreation where all participants “win”, that was all positive reinforcement, with zero or minimal negative reinforcement could be beneficial. Marathons remind of this.

New multiple ways to win at an athletic activity, notably marathons: just possibly at marathons or other athletic activities artificial goal-producing measurements like pulse, blood pressure or lung volume could give people four things to excel at, so if they did well at one they might feel better/happier at having participated in the activity: a personal best time, a lower blood pressure number, an amusing pulse number, or a higher lung volume utilization number could be multiple things where doing well at one colors theimpression of how well the activity went. That could be called: Multi-Win structure

It is possible laser sensors aimed at a mass group of athletes or at an area where they pass singly could measure blood pressure and body temperature and breathing rate/style. Also cameras or lasers could note and display foot-pick up style, or the amount the person has optimized their physical running style to gather the data for the multi-win components.

Science of psychology scientists, like happiness researchers, could measure if having multiple ”win” (multi-win) categories previously stated at an activity causes greater individual or measured bulk happiness at the result of the activity. Then if multi-win is quantifiably measured as improving being then the multi-win thing could be technologized to actual procedures and/or objects to make versions of things and interactions that purposefully create multi-win at a wide variety of human activities.

There is even the chance multi-win structures could improve office work. This might replace the two part “but” cognitive structure where someone might have previously thought, “they didn’t become a client, but I made a great powerpoint that I can use with the other prospectives” being replaced with “I won on 4 out of 5 fronts; great powerpoint, on time, networked and got a new phone number, found out about their European branch, giving me a new prospective area”.

Researching specific word and thought forms makes this more than just the mental practice of intentionally listing out some things that went right, Example: computer-practiceable “three things that went right” structure could be a new educational software practiceable habit of speech and thought that says “multi-win” to the limbic system (and the emotive non-decisive perhaps narrationless part of the mind) thus increasing quantitatively measured happiness. and the non-decisive part of the mind as compared with the two item “but” version. Also, more research could find out about making the multi-win categories cluster around ideas that improve employee/worker capability, adaptability, and enthusiasm for the job.

Regarding improving place of employment existence: this might also be particularly applicable to things that do not matter. It is possible that a variety of things that are now quantitatively measured as psychologically neutral could be newly thought of/restructured as producing “approving rememberance” or “perceived wins”. Perhaps predicting neutral events like lunch contents, parking space utilized, or a co-worker appearance could produce a thought where when the actual things presented themselves the person, and fit the prediction the person would experience one or more parts of a multi-win.

So as a technology this might translate to: thought form suggestion: Predict three things that will happen today that you like.

One example of multi-win creating greater happiness at neutral things might be reorganizing/structuralizing the mental impression of the cumulative psychological effect of non-word vocal tone and body language of office greetings.

I think right now people think something similar to: “experience warm greeting; feel good!” quantity of experiences with also some: “Akward eye contact, no speech -> nonoptimal feeling; -> reassures self it meant nothing” moments. So the person might get some multi-win structure practice thinking new views like “three people said hi to me!” “everybodyon the elevator looked happy” A formulaic, practiceable, possibly computer-teachable and practiceable, way of batching nonverbal social interactions could generate greater happiness from actual unimportant things that actually happen, even though these actual things, like other people’s body language are of vanishingly minimal meaning. There might be science of psychology measurements of how a multi-win restructuralization of a neutral stimulus like the body language of strangers also replaces previous negative thoughts by simply occupying the mind differently.

It is possible some branchings of “won on 4 fronts out of 5” build both happier feeling and greater personal ability. If you are supposed to search your mind for winning front contents that cause greater [value and effectiveness] at your activity or employment focalizing on heightened thing quality, or more future options opened then you also reinforce the strength of these things as values that you happen to live and do things at. “when you look on the brightside, make a list, and practice the multi-win structures and self-talking things that are beneficial and have utility at your goal or preferred-version-of-life context”. This of course is also a technologizable thing, with educational software when you win on five of five things and/or get what you want, perhaps speaking aloud to the computer running the educational software.

Perhaps by creating multiple classes of “winning” at one activity the quantifiably measureable effect on happiness and well being goes up because there is always an upside result. This could possibly be combined with the “get to” phrasing that at self-talk is published as causing people to feel better/happier when facing a task. “I get to make a powerppoint today” is, to my perception, scieince-of-psychology measured as raising mood and effectiveness more than “I have to make a powerpoint today”. So things like, “I get to measure my blood pressure while seeking a personal best at the marathon” might create more satisfaction/positive reinforcement than Just running a marathon or measuring blood pressure seperately.

At romance, thinking the food was good, even if there was no interpersonal romantic chemistry is a possible example of variation on multi-wins being possible, although of course it is better to have romantic chemistry along with good food. It would be awesome if there was multi-win research on human romance and attraction, thus improving people’s lives. “we made some good eye contact”, “I believed the honest compliment”, “I spoke in ways that built empathy rather than startle-arousal or the rather dubious ‘playful confrontation’ to increase the compellingness of the conversation”,” I got her email and phone number and we sent each other into Hi texts/emails/social networking participation objects (snaps)”; emphasizing: rather than providing consolation, multi-win causes feelings of success. So the romance researchers would study multi-win structures and thought-samples that increase confidence and, beneficially, increase incidence of second dates.

For those that like doing art, it is possible that things like watercolor or painting provide moment to moment experiences of microsatisfaction at brush placement and the feel of the moving brush.

Hobbies have some popularity. Although paint-by numbers has minimal popularity it is possible some variation could provide the microsatisfactions of making art live with a result that always looks good. Possibly rearranging the furniture or deocrating a dwelling provides similar pleasure of action with satisfaction at the overall impression of the new ensemble.

With neural implants a small-talk swapper could be produced. The most optimal forms of greetings and vocal tones at each actual different person at producing happiness could be scientifically researched and technologically produced as well as customized to the individual; swapping out what you hear, and the tone in which it was said with the new version that increases happiness while still supporting cognition of its meaning. Hearing “Yo! mouse is in the house!” is translated to “Hello, You arrived! I’m happy to be here with you and am looking forward to all the activities that are likely to happen at this wonderful place” This could also be used to retranslate non small-talk to be more psychologically beneficial to the hearer.

Polite driverless cars: It is possible that at a competent effective computer-driven car there is actually a range of possible behaviors; perhaps anywhere between 3 and 10 feet can be automatically preferred as spacing between cars; signalling at lights might start earlier or later, and which of several available turn lanes is utilized might be modifiable. That latitude of permitted behavior at these and other attributes, suggests that there are driverless car behaviors that optimize the felt experience of any live humans driving near a driverless car. Driverless cars could be engineered to be intra-car polite and reassuring to humans as well as safe while driving.

They could do psychological measurements on children’s book covers;

If a person repeats a thought in their mind, an actual thought, rather than just words, does an fMRI of their brain show repeat activation of the same areas? Does repetition of the actual thought gradually or suddenly physically relocate it to some other area of the brain. This could be a way to link behavioral psychology to the actual content of thoughts using fMRI. Perhpas they could find that self-talk without acute awareness is less (or non) reinforcing as compared with moment of realization thought combined with internal narrative. Noting this is sort of like “rambling self-talk is cheap, and minimally effects actions, but moments of realization are/are not producing of action when combined ( or not combined) with self talk.

They could do fMRI of a a survey panel of many existing and new drug molecules to find those that increased the amount of moments of realization. localizing drugs with fMRI could assist drug development with concentrating things that up ATP production or neurotransmitter generation/release at those specific brain areas that go with moments of realization.

It is possible that the length of an alkane tail at a drug is a nonreactive way to adjust the passability of a chemical at a lipid membrane, so a propyl tail drug might pass through completely different body location membranes compared with a heptyl alkane tail. Mapping out where the different tail lengths accumulate at the brain (and other body tissues) could create some amount of drug localization that could be used to focus drug effects. At cognitive drugs this could cause particularized mental and emotional effects some of which could be preferred uses.

A medically beneficial version might be tails made of “half an omega 3 lipid” or mini-length monounsaturated fatty acids, where on reaching the membrane the new lipid would actually benefit the membrane it had customized permeability at. That might be better/less risky than milligrams of heptane per dose accumulating at cytomembranes.

Then there is the possibility that membrane transport proteins differ between different types of neurons. If so, then attaching a neuron-specific transport protein to a drug molecule could get it to reach the cytoplasm of just one type of neuron. Could also work at mutually exclusive membrane transport proteins at whole body tissues to make medicines focalize. This could also work at glia. Again, this localizes drug delivery.

Can drugs harmlessly tether to exterior-of-cyte proteins, then have physical-chemistry favored diffusion into the cyte they are nearest to? This is a mild variation on aptamer based localization, which has similarities to immunostaining, and could of course be modelled in software as a huge map or library of which body and brain physical sites go with which aptamer shapes.

Software brain map: Software that combines an up to date, even continuously updated, positional and/or more advanced map of brain and neural fMRI regions’ cognitive, emotional, physiologic, noncognitive “computational”, memory, somatic mapping, visual and other sensory, and other brain attributes, products, reactions, structures, The advanced map could be more than positional, reminiscent of a “braineome”, represented with a variety of possible data structures/math at the computer; AI, even the 2019 AD Deep learning, could find new linked “diffuse yet monad like” map-item effects and self-cohering systems (cybernetics) at the brain map.

I read somewhere that some biological systems are like a bunch of network nodes set at middle values, and thus perturbing one of the nodes to much higher gets averaged out because of the plurality of nodes it connects with; one perception I have of what I read is that, at a network, doing effects in isolation could require and or be possible with mathematical insight. Visual and math examples abound, like standing waves or focalized fluid leaps at the center of a concentric wave. Using the software brain map to search for systems and structures that are mathematically prone to easy isolation and amplification effects produces new utilizable technologies of single-effect beneficial brain improvements. Optimally these would be sustainable, possibly permanent upgrades to brain function. Beneficial pharmaceutical products as well as genetic engineering of human beings to have heightened intelligence and other brain based things, possibly including longevity (SN brain area; deprenyl) is enhanceable with applied mathematics on a software map of the brain.

.5B

Like laser-comparison-beam indexed astronomy could something like spin polarized drinkable/snortable index forms increase fMRI resolution at the head; when the spin-polarized coatings on the snorted .1mm particles and the 1 mm particles are both in focus then that math-of-fMRI processing and/or magnetic sensor calibration is at the new higher quality, littler thing-resolving, focus. It is even possible that an injectable blob, like a harmless “good cholesterol” focus-index blob could be sizeable enough to heighten fMRI focus while being physiologically harmless, or, as “good cholesterol”, beneficial.

New nonstimulant actiontropic nootropic: more moments of realization could cause more moments of action. More things done each day could improve quality of life, realized opportunity, and good-feeling experiences of positive reinforcement.

Building on fMRI of moments of realization mapping, the genetics of more moments of realization could be a specific region of intelligence genetics that improves people’s lives with genetic engineering. Brain structure as well as neurotransmitter and neuron type could be among many genetically modifiable things that contribute to larger actual numbers of moments of realization.

Hey, they could research this stuff.

Different cognitive bonuses, lumped into the measurable quality called intelligence have individual characteristics, each of the characteristics could be the topics of drug development and genetic engineering enhancement:

(some drugs,and fuzzy impressions of their notable, isolatable, developable, technologizable characteristics; I could enumerate or taxonomize the different characteristics)

phenibut: It all looks good, because your mood is good, and good things generate more spontaneous enthusiasm to realize/consider/develop from, so new things and ideas happen and the mood is sometimes right to write them down, producing what might be product

phenylpiracetam: as a computer metaphor, CPU and libraries are bigger; is absent motivational and attentional component; reminds me of just having more capacity, like scanning bigger arrays without conscious action or self-talk enunciations, knowing more words, thinking with tighter cognitive links; higher quality product, but no particular heightened drive or sense-of-fun-in producing product.

LSD: its so amazing you have to pay attention, also I perceive thoughts have a larger than not-on-LSD number of overlapping mind-dwelling-time fields of existing knowledge and/or awareness; new ideas that present with the preapproved feel of known ideas occur, and these are emotionally enjoyably sustained and further promote interest in the branches and growth from the new yet preapproved ideas to produce lots of assumption of big-gist thoughts; I do not have any references but I think LSD does increase after trip cognitive and emotional and empathetic capacity. Mental form characteristics of LSD, just a few of many, from memory.

Moments of realization of drug: You have gist-of awareness of a fresh realization five times more often than when you are not on the drug; it is not that things are so fascinating, it is that you focally perceive numerically more frequently

Surplus of focused attention: seeks out things or ideas to be attentive to: drug; this might describe some stimulants. A stimulant I get off Ebay causes me to have perhaps a month’s quantity of new technology ideas in one day (as compared with my latuda-drugged monthly output), and the willingness to pass the threshold of action rather than sitting still causes me to type them out; high productivity drug.

Each of these drugs is active at a different form of intellectual experience and likely brain and neuron activation patterns. Mapping more forms of intellectual experience and productivity to brain areas and structure, and microstructure, and chemistry and biochemistry, creates areas that heighten the effectiveness of new drugs and the benefits of genetic engineering human beings.

Food length-of-edibility-and-storage increasing technologies:

coanda cool air curtains (lower energy use); silos constructed to permit air-curtain ariflow at their geometry.

something really cheap, like cellulose flakes that can slip between fruits so they have a tiny air-permeable gap between each other, reducing condensation and spoilage

.5B

6 month TBHQ; it is possible that an strong micro-dose antioxidant preservative like TBHQ could be sprayed on food in minute amounts, strongly increasing storage life; the thing is that this technology is a spontaneously degrading molecule that is converted into harmless, preferably GRAS chemicals after say 6 months. That way it stores with lots of preservatives but is eaten without any of the storage preservatives. Chalcones are at Zubbles, colored blow-bubbles, they are molecules that last minutes in air, but are stable in liquid solution. Perhaps a novel size or form of chalcone molecule attached to a known preservative could make a molecule that splits apart to harmless components with 24 hours out-of-silo air. Another possibility is zapping everything on the conveyor with a beam of UV that disintegrates the peservative molecule, which might have a very light-frequency specific response.

.5B

Cheap nitrogen preserves food: does electrolyzed water, the acid part, like to glom O from O2 out of the air into the fluid leaving nitrogen? This works already at: use electricity to bubble out hydrogen; combine with oxygen, making plasma and water. So, going for a much milder reaction, does hydrogen enriched liquid electrolyzed water (H3O+) react with bubbled air to react the oxygen leaving nitrogen gas as a preservative? A catalyst might make this better.

Online it says of electrolysis catalysts, “GridShift brags their technology [hydrogen producing catalyst] reduces the costs with the catalysts by 97 percent, with an ounce costing just $58” (2010). It is nanogeometry based, “coating a complex three-dimensionally shaped electrode on all surfaces with a unique combination of readily available nano particles that expose the catalysts to the electrolyte for efficient water electrolysis reactions and is robust enough to withstand the rigors of electrolysis.”

If it does then you could use electricity almost alone to run atmospheric air through turing it to nearly pure nitrogen for things like cereal silos, possibly even making a “nitrogen blower ventilation fan” at a silo. The waste product, ionic water, is likely harmless, as it can be evaporated at ponds.

Along with use at the developed world, photovoltaics might make nitrogen a functional preservative at the developing world, although I have doubts because of leaks.

tank coatings: could tank interiors be coated with a food preservative? Drones could spray refresher coats on big silo-sized tanks.

antibacterial peptide; reducing bacterial growth may preserve food; wikipedia says, “Antimicrobial peptides are a unique and diverse group of molecules, which are divided into subgroups on the basis of their amino acid composition and structure.[2] Antimicrobial peptides are generally between 12 and 50 amino acids.” So, genetically engineer food plants to make antibacterial peptides, then the foods might be autopreserving. One possibility is to localize the production of the antibacterial peptides to rinds, hulls, even plant-stem interfaces which keeps the peptides separate from human consumption. Unknown effect on GI tract bacteria. Also, they could seek novel sources of antibacterial peptides, avoiding the ones that humans produce. That keeps human antibacterial peptide resistant bacteria from developing. So, perhaps antibacterial proteins could be found at pest insects such that if the bacteria develop resistance they might inadvertantly also be lethal to insects. It is possible that some kind of organism produces an antifungal protein; that would be another source of food preservation genetics.

It might be possible to think of a new preservative molecule that does a few things simultaneously, like an antioxidant that is also bacteriostatic or bacteriocidal, and possibly a pH optimizer and a

I read something that suggested that washing off fruit with a low pH liquid, then drying it caused 19 days without decay as compared with 11 days at unwashed fruit. That might suggest that washing fruit causes it to last longer. So, the area of thought is: How clean goes with how much preservation? like PPM (parts per million), does fruit last twice as long at 1 PPM dirt as compared with 1000 PPM? that direction of thought suggests that it might be possible to improve cleaning the outside of fruit.

I read that curing root vegetables makes them store better, with less decay. This recipe https://www.wikihow.com/Store-Sweet-Potatoes is startling, “Cure the sweet potatoes for 1 to 2 weeks. Keep the roots in a room or other location that reaches between 75 and 80 degrees Fahrenheit (24 and 27 degrees Celsius) with relative humidity of 90 to 95 percent.

• The sweet potatoes need to cure for at least 7 days, but they can be kept there for as many as 14 days.

• The curing process creates a second skin that forms over scratches and bruises”

This 80 degrees for two weeks at 95% humidity to “creates a second skin that forms over scratches and bruises” is amazing. It could be that humid warm conditions for two weeks causes some harmless bacteria that dries in place at nutrient-oozing dings to be a preservative or moisure-loss blocker.

It is possible something colonizes the surface at 80 degrees, 95% humdity, for two weeks. That brings up the possibility that with bred or engineered new varieties of the hypothetical bacteria, the “second skin” that preserves could be produced with the new bacteria at a variety of crops, with less time or easier ambient environment (cooler, briefer, more similar to existing ambient-like humidity);

Also, the possible use of bacterial polymers, as newly produced things at root curing bacteria, possibly something like polylactic acid, to be deposited specifically at nutrient-oozing spots of produce to produce a second skin might be a new-to-me preservative technology. As previously described the bacteria could be engineered to produce their polymer at minimal-effort existing ambient temperatures and humidities.

If it isn’t bacteria making the preservative second skin it might be sugar or complex carbohydrates seeping out to make a dried plug. I have read about bacteria, which may be genetically engineered, that actually export liquid sugars like glucose to their environment, so it is possible as a new preservative technology, a humid area but not wet root could have a sugar generating bacteria growing on it, plugging holes, making plugs, and creating a second preservative skin. Inoculating the vegetable/root/fruit with the preservative bacteria would be like a quick probiotic produce wash, or just possibly a spore air-puff, and could work at a variety of crops; it also seems nice to have the opportunity of an edible carbohydrate barrier layer like sugar alongside the plant-based polymer like the polylactic acid opportunity that might cloud preparation water.

There must be many second-skin preservative polymers available but povidone occurs at this moment. Approved for food, povidone is kind of like vinyl; the thing is there is some cheapest water-soluble polymer paint for produce and some other crops.

.5B

Regarding blocking decay at sweet potatoes with the 95%/80d/2 weeks protocol, as well as blocking decay at other root crops at the developing world, perhaps a very cheap trash bag with a well thought out semiporous side panel you toss water on once every two weeks could be a “yam protector” that makes the 95%/80d/2 weeks thing easy, so people with only a few hundred kilos of yams can just bag them up, and have the modified plastic bags make the environment to form the “second skin” preservative layer for them. If things worked really well they could just leave the root vegetables in the big trash bags all year. Optimally the trash bags with the semiporous side panel for water could be reused several times.

This semiporous water side panel trash bag preservative technology might also work at other root crops; taro,

slight computer browser improvement: click something to search all the tabs upfor a phrase; if I have 70 tabs up they are all over the place and I have no idea what they are about, but a clickable “search tabs for:” thing would sometimes be beneficial

Lactobacillus and possibly other fermenting bacteria, could be bred or genetically engineered to produce a larger amount of vitamins, then possibly it could be exported to a variety of places as a new preferred probiotic for fermenting local foods, thus benefitting nutritional sufficiency. I just read that people ferment tapioca and that tapioca has twice the calories per acre of food production as wheat during about 2019 AD. Online it says tapioca was one of the world’s 10 most consumed foods at 2019 AD. I am reminded of the technology of printing vitamins onto edible images with vitaminized printing ink. It is possible that new vitamin-producing fermentation starters could be printed with ink on paper that was then a part of advertising, thus spreading it widely.

Among the vitamins at the new fermentation bacteria, it is possible B vitamins, including baby-benefitting folate, could be engineered into the world’s ten most frequent fermented food bacteria. Although it makes sense just to engineer the production of all the vitamins possible into the fermentation bacteria.

I read that some people at the developing world eat tapioca, and drying tapioca to make something like flour occurs; drying tapioca sometimes uses fuel to provide warmth, thus an engineered or bred tapioca that grows just as well that has 25% lower moisture content when ready to harvest could reduce wood gathering efforts and/or make preparation cheaper. This beneficially reduces the amount of labor used at the food process.

I favor automated mechanisms harvesting and distributing and preparing all food. There is previous writing that describes the benfits of mechatarian style of existence. Benefitting both those mechanisms and humans who might prepare food is making the crops optimally minimally fiberous. This saves both human and mechanical energy. Online it says of tapioca, “The most unpleasant part of the process was considered by the women to be the "gasifying" as during this they are exposed to steam for many hours at a time” I perceive that that activity is linked to the toughness of the tuber. Genetically engineering tapioca and other root crops to be minimally fiberous/tough is a way to directly benefit humans.

I read that during 2019 AD rice was a popular food. I read online that storing non-polished rice, which has more nutrients, that the high oil content of the bran and germ layers could be an opportunity for better preservative technology. It is possible that mycorhizzial bacteria/fungi at growing rice could be genetically engineered to make lipid soluble, antioxidants that would cause the rice to stay fresh longer. Vitamin E is produced at biological organisms, so might be possible to engineer as a bacterial product; but does vitamin E near the roots have any effect on antioxidant levels in the seeds? Golden rice, and engineered product, has heightened beta carotene content at the grain; perhaps genetically engineered tocopherol rice, perhaps also with genetic engineering produced ascorbic acid to preserve the non-oil area, could make a kind of nonspoiling rice.

Creating new technologies is beneficial. I have some ethical concerns about just writing words to motivate readers; one area of imaginable research is to look at the (online) list of the ten most eaten foods, then use engineering to make them all take 1/2 the chronological moments, and perhaps 1/2 the effort, or less, to grow, store, prepare, and eat. This would free up the equivalent of hundreds of millions of person-years of free timefor people worldwide.

Online when it describes money expenditures, prior to earnings, of Iowa farms during 2019 AD,“Dry (LP Gas @ $1.38/gal.): is the largest outlay item at the category “Harvest Machinery”:

fixed variable

Combine $13.10 $6.70

Grain cart 6.30 3.00

Haul 7.16 6.19

Dry (LP Gas @ $1.38/gal.) 8.20 27.16

Handle (auger) 2.89 3.17

.5b That suggests that technologies that dry crops more cheaply could benefit agriculturists, make food even cheaper, and save energy. I have not looked it up online but I have not heard of a coanda effect (air plane producing) gas crop dryer.

Genetic engineering could possibly create a corn variety that has lower moisture content on the cob at harvest; changing fresh kernal moisture 20% could result in drying it with 20% less energy. This ground-meal cereal dryer seed variety approach could be used at a variety of kinds of crops that are purposefully dried prior to storage.

My perception is that higher surface area causes faster drying. although it could actually be a chemical engineering Kcalories in -> Kg water out, number for a sufficiently ventilated system, with the only variation being drying time. Is there anything cheap that could tumble with the corn in the dryer, then dry out gradually at a different area, with time? Some novel polymer that really likes to evaporate water away from its surface even at like 60 degrees/overnight temperatures at harvest season. This is basically the opposite of a hygroscopic polymer, softwood comes to mind, so perhaps some new genetically engineered straw that has a morphology and chemistry that just really likes drying out, possibly with a very high surface area (possibly fractal) straw leaf microsurface. Such a straw would be cheap. Such a hyperdrying straw could also have nutritive value to feed milk producing organisms and might dry better than usual hay. (no knowing what its water usage is while its growing though) So, at the listed chart, the corn goes in the dryer (might be rotary dryer) with the water-glomming, but favors evaporation, new form of straw. Then the easy-dry straw perhaps just rotates at a cool drum overnight to dry.

Another possibility could be a warmth-moisture reactive custom carbohydrate with a favorable phase diagram. wikipedia says, “Starch gelatinization is a process of breaking down the intermolecular bonds of starch molecules in the presence of water and heat, allowing the hydrogen bonding sites (the hydroxyl hydrogen and oxygen) to engage more water. This irreversibly dissolves the starch granule in water. Water acts as a plasticizer. Three main processes happen to the starch granule: granule swelling, crystal or double helical melting, and amylose leaching.

Between sugar water and crystal sugar and starch (noting also geometry-improved starches like febreze) are different amounts of hygroscopicness; if crystal sugar, or customized starch, pulls water out of the air faster than the corn emits it, then perhaps the corn dries faster; then the likes-to-dry-out custom starch evaporates away its water overnight even at 60 degrees. I think a chemical engineer might say evaporation from the custom starch depend on the airflow around the particles of a particle size, at a particular temperature and ambient humidity. That supports the separate cycle cool weather drying of finely divided enough custom starch to fully dry the starch for re-use at the next dryerful of corn. I have seen psychrometric charts showing how minimal evaporation is at lower temperatures, but it still occurs, so particle size and breeze velocity are really the thing to prep the custom starch repeatedly for fresh batches of corn. Perhaps there are also nonexplosive micro-particle dust versions of custom starch.

Not that it matters, but diamond dust, nanoetched with hygroscopic superhydrophilic troughs, with its high heat conductance reminds me of this corn drying thing, if it were something other than diamond dust.

So, what is the cheapest organic molecule with the highest specific heat, that skips exploding when like a floaty dust? Maybe there is an FeStarch, but I thinkIhave heard of a FeSugar: iron gluconate might be heat conducting and hygroscopic cheap and nutritionally neutral.

Another possibility to customize the drying co-material is to make an activated-high-surface-area version of starch, possibly from gelatinized starch first dried out with ions from like dissolved calcium chloride. When they make activated carbon they soak charcoal in an ionic solution, I think I read calcium chloride, then let it dry out, and the eentsy crystals formed tremendously increase the surface area of the carbon; related to this could be loading starch or sugar with ions before gelatinizing it; “Water then enters via amorphous regions the tightly bound areas of double helical structures of amylopectin. At ambient temperatures these crystalline regions do not allow water to enter.” so theoretically, if some of the glucose-y monomers the starch polymer was made out of had ionic character, or some wild hydrogen hydrogen or sulfur-sulfur link like amino acids, then it would be able to suck water to in between the starch polymer streamers.

Thinking about that different thing, nanopatterned diamond dust could have some kind of RF activated pivotability of the superhydrophilic troughs to superhydrophobic needles, thus possibly changing the shape from really likes to absorb water to really likes to evaporate water.

Is there a cheap way to do the same shape change at the much cheaper custom starch? You could have something like telescoping collapsible drinking cup shapes made of starch, that when it absorbs water autotelescopes out, and increases its bulk volume at the dryer; the telescoping of the cup increases its surface area; then tumble drying of the larger surface area starch blobs at low 60 farenheit shrinks the collapsible cup back down. Febreze has a custom geometry called a cyclodextrin, it is just barely possible that a telescoping starch with a rapid-dryable shape that is there when wet could be produced.

Another possible approach to making corn cheaper to produce is a new corn product, minced corn; mince then dry, 1/3 of a normal kernal size dries faster than whole kernal yet remains flour maker friendly? Does swapping out 100% of extra energy of warmth with the equivalent 100% energy of coanda effect planar air entrainment dry corn faster? Is there any chemical engineering basis to think that all air motion at background temperature is more effective than just warmth?

Preserving soybeans:

Writing from March 31, 2019

Longevity technologies:

NMN is published as causing tissue to revert to younger form; have probiotics or gene therapy produce NMN at the body, automatically producing circulating tissue youthfulness chemicals like NMN without having to take pills. Genetically engineering people, that is humans, to produce NMN causes a younger body phenotype from the genetic improvement.

Rapamycin causes laboratory rodents to live 60% longer; perhaps at humans variations on the rapamycin molecule that concentrate at different tissues could cause different, optimizable longevity effects, possibly while minimizing the effect of rapamycin on the immune system. So, hydrophilic or hydrophobic variations on rapamycin would concentrate at different body compartments and tissues (medical word: compartments) and could be measured as to effect on both longevity and immune system effects. This could produce a longevity beneficial version of rapamycin that is absent immunoeffects. Besides hydrophobic or hydrophilic variants, new variants on rapamycin could have a chlorinated benzene like centrophenoxine attached to it, which could cause transport through the blood-brain barrier possibly producing brain youthfulness. Also, why not throw a fluorine or two on ithe rapamycin molecule and see what it does, perhaps with effect at a tremendously tiny dose.

I may have written or recorded an audio file about this previously: I think I read that contact with younger people causes older people to live longer. They could test youth-level odor effects as well as possibly pheremones on extending lifespan and healthspan. Also, software that imitates communication with a younger person could be measured as to longevity effects. This youthful interaction effect could also be structuralized and emulated at companion robots, causing greater longevity, from a robot, and/or robot companion that is produced with the purpose of physically caretaking an older person.

GSK: Rapamycin as anti-dermatitis technology and youthfulness skin treatment. Possibly as an antiproliferative chemical, rapamycin keeps the body from coating stents with tissue when the stents are treated with rapamycin. Noting rapamycin makes lab mammals live longer, could the antiprolifereative effect be used to reduce skin lichenification and/or hyperproduction of skin flakes or exudate crusts; atopic dermatitis’ things?

Possibly likely to be better than some drugs as the beneficial side effect could be local topical tissue youthification or delayed skin aging from rapamycin. Like the skin localized version of 60% greater longevity at lab mammals. Also topical amount absorbed at the body could be eentsy enough to have zero immunoeffect.

longevity technology

“the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%-6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan”

At a human that is less than 200 calories a day, so glycine candybar might be a slight longevity drug in treat form. Glycine is $2.80-7.20 per kilogram at alibaba and 200 calories is about 50 grams a day, so approximately 20 servings per kilogram or 20 cents a day.

I think I read that things like piracetam and other racetam nootropics are variations on glycine which at large doses is a mild nootropic. That suggests some different molecular forms of modified/imitated glycine could have greater longevity effects than undecorated (unmodified) glycine. It is possible various dioxyphenyl, phenyl, chlorophenyl modifications to glycine concentrate at the brain increasing brain youthfulness.

I am not aware of studies on trimethylglycine but it is cheap and there is conflicting published material on the benefits and non-benefits of bodywide methylation

Is there a list of differential aging rates at different tissues? If there is then longevity drugs with chemical groups that cause them to concentrate at the most aging prone tissues could be longevity drugs that might possibly reduce the perception of felt aging as well because along with increasing healthspan they can possibly produce (chemical:NMN, NR) young-functioning tissues at those areas that people mentally notice most, first.

Not particularly new: differences in mitochondrial number per cyte at different tissues, or variations in telomere length at different tissues at different chronological ages could be a guide to differential aging at different tissues. Pubmed supports this, one paper says, “the AGEMAP database includes expression changes for 8,932 genes in 16 tissues as a function of age. We found great heterogeneity in the amount of transcriptional changes with age in different tissues. Some tissues displayed large transcriptional differences in old mice, suggesting that these tissues may contribute strongly to organismal decline. Other tissues showed few or no changes in expression with age, indicating strong levels of homeostasis throughout life” Also, “We observed that different tissues age in a coordinated fashion in individual mice, such that certain mice exhibit rapid aging, whereas others exhibit slow aging for multiple tissues.” which is encouraging as it suggests a simpler upstream guidance system, that, if they feel like it, scientists could find, that causes many cytes and tissues at the body to have slower aging.

Startlingly, the paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098796/ [Gene Expression Database for Aging in Mice, which I am acryonymizing GEDFAM] makes me think that “topping up fluids, preserving tissue and/or youthful biochemical levels” might be ways that some 2019 AD anti-aging technologies (metformin glucose and AMPK; deprenyl: SN brain structure preservation; senolytic effects) improve things. That paper says genes modifying the protein output, which I think of as including receptors and activators of receptors, at mice may be different than humans’ at affecting longevity and healthspan. That suggests the directed adjustment of the human body to younger versions of brain (SN: deprenyl, AMPK metformin, senolytics, that thing where they connect a young animal’s circulatory system to an old animal to extend lifespan/healthspan) and tissues with macroscopic agents or protein manufacturing gene therapy, might be seperate from mouse based genetics of possible differences in tissue aging and youthfulness with sources at a genetically directed thing. The quote is, “we saw no overall correlation of age regulation between mice and humans, suggesting that aging processes in mice and humans may be fundamentally different”

This (GEDFAM paper) brings to mind some peculiar possibilities: I think I remember that mice and people share about 80% of genetics. If the mouse genetics of aging are actually not correlated then that suggests that the other 20% of the human genome that is human-only contains the genes that affect human longevity. So, a place to find stuff. It is nice to be on the human side of this that lives 40-60 times longer than the mouse side. Also, the macroscopic quantity-material-effects like senolytics, or AMPK change, or even that thing where they connect a young animal’s circulatory system to an old animal to extend lifespan/healthspan as a result of circulating chemicals at the blood could be based on mouse-human shared molecular products, rather than genetics of the source of the shared biochemicals, Colloquially, kind of a “different carpenters, same furniture produced, option to redecorate either species with youthifying pieces of your preference”.

Also encouraging, even though the quote is quite startling, is that gene reregulation at things like yeast, flies, mice and fish, causing greater longevity are conserved between and across species, suggesting that longevity and healthspan increasing bulk materials/proteins/receptor forms are conserved between many species. Colloquially, “more than one way to build a NAD, but more of it makes any measured species have greater behavioral verve and healthspan”

Also, the link between mouse genes and human genes at reducing aging and increasing healthspan might still be there. It is possible that the noncorrelation they found is a big-sample 16,000 gene numerical effect, while for a smaller subsample of genes, like the multispecies conserved longevity producing genes, the predictive power of the smaller group of genes could be high and a basis for productive beneficial longevity reasearch.

That genetic difference between mice and humans increases an emphasis on using human tissue culture to find longevity and healthspan increasing drugs and treatments, as well as finding the human genes of longevity and healthspan. Also, they could solicit paid human volunteers to take new longevity drugs during development.

Finding people who are physiologically younger than the median physiology at a chronological age: “Using just two cytosines from these loci, we built a regression model that explained 73% of the variance in age, and is able to predict the age of an individual with an average accuracy of 5.2 years. In forensic science, such a model could estimate the age of a person, based on a biological sample alone” Suggests that they could take samples from a million people to find 99.999th percentile of biological youthfulness to optimize human genes and do gene therapy. What might also work is computer image recognition that is functional at predicting +/- 3 months of actual chronological age, then screen about a billion people on social media and proffer cash to the 1000 one in a million most youthful.

Scientists could study when tissues and people first begin the curve-graphable trends when the curve trendable aging processes that occur from 40-120 start. It is possible that at children these biochemistry of aging curves have not started or graphically trended up, that is it is possible aging does not actually start until puberty. That suggests that stem cyte tissues developed from pre-aging action curve samples could be a youthful tissue basis for medical treatments. Also, repositioning various physiological levels of chemicals and gene expression and blood & plasma concentrations of a variety of biochemicals to be those of the pre aging curve trend (youth absent aging) tissues could just possibly park the persons tissues in ageless, that is absent genetic and phenotypic movements towards aging, form.

This paper https://www.ncbi.nlm.nih.gov/pubmed/27135913?dopt=Abstract “Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats” has a graph, figure 2, with startlingly large differences between brain and liver gene transcription rates at tissues of young or old rats. The differences are measured in activity levels that are 2-8 fold differences; 200-800% differences in output. At old rats, immune system genes at brain are turned up 500%, that suggests the possibility that an immunization of some kind could benefit the brain, either medically blocking some immunostimulus that the brain is reacting to, or causing a beneficial immunostimulus. Lipid responsive genes and response to hormone genes are transcription responsiveness increased 200-300%. It is imaginable that heightened responsiveness to these things at old brains could run the system at the perimeters of it capability, causing non-smooth nonlinear outputs that cascade to make a mess. Modifying the hypertranscription of these 200%-800% different genes could maintain younger phenotype longer.

GSK: New drugs that make up for liver changes: The paper has numbers for the liver as well, which could affect the wellness of the entire body. “small molecule synthesis” is decreased 200%. Regulation of ion transport is up 400%. That suggests medical technologies to supplement older people with the missing or reduced amounts of the “small molecules”, also the ion transport thing could suggest customized electrolyte supplements or liver concentrating nonorganic-linked-to-organic molecule (like a protein) chemicals, “magnesium aspartate” or drugs that produce the (chronological age reduced) ions at the liver.

Some brain genes are transcribed less at old rats. the paper lists genes that are 200-600% less active at old rats’ brains ion channels; g coupled protein receptors, and “neuronal action potential” are all many fold lower (200-500%) at old rat brains. Upregulating these with medicine/technology could create greater youngness of mind as well as better non-conscious brain-directed (cerebellum, brainstem) maintenance of organ and tissue systems that get instructions from the brain.

The paper seems to talk about how much the different transcription rates affect the actual amount of protein, “We assessed the correlation between translation and protein abundance … The correlation coefficients increased to 0.37 for brain and 0.42 for liver when only significant cases (either at the translation or protein level) were taken into account.” It is possible I am confused and this is a numeric methods statement, as I do not think they measured the rats’ brains, physically extracting and massing the proteins findable there.

At a different paper, the GEDFAM paper that looks at 16,800 mouse genes and compares aging in 16 different tissues and the amount of gene expression, says, “the aging expression profile for different tissues showed three main patterns for murine aging (neural, vascular, and steroid-responsive)” That (neural, vascular, steroid) pattern or other separable areas of tissue and/or describable area at aging could be researched to find out if the actual proteins and chemicals at tissues could be a separable systems that are addressable at humans. With new, research supported, buckets to address with longevity technologies humans might also have three or more comparatively independent areas to direct further research at and develop longevity drugs for.

The 16,800 gene study of 16 different tissues (GEDFAM) also says, “We dissected 16 tissues from each mouse: the cerebellum, cerebrum, striatum, hippocampus, spinal cord, adrenal glands, heart, lung, liver, kidney, muscle, spleen, thymus, bone marrow, eye, and gonads.” So one thing they could do, even though they say the mouse and human genes do not correlate, is to find out if the biomarkers of aging correlate between mice and humans, for example, at aging, some biochemical raised or reduced at both mice and humans; that would support the (metaphorical) different carpenters, functionally equivalent products” colloquial statement. If those bulk effect biochemicals correlate between mice and humans, then they could find new technology product-based changes between young and old mice and then seek out similar things at humans.

The 16 tissue GEDFAM article also says, “Age-related expression changes are relatively small in magnitude; most genes increase or decrease expression less than 2-fold over the course of life. The remaining seven tissues showed little or no age-dependent expression changes.” Disease that effects those 7 tissues could be things, that if cured are removable sources of possible lethality than can be addressed as a part of increasing human longevity even at a human who has their youthfulness extended with drugs, therapies and if they or their parents like, new or customized genetics, including eugenics.

Preventing or curing illness at the cytes and tissues that are absent chronological change increases average longevity. It sort of like driverless cars as a cure to save the lives of teenagers; reduced mortality even at physiologically young organisms. The 16 tissue GEDFAM study notes 7 tissues without much change in gene expression with age: cerebrum, striatum, hippocampus, adrenal glands, liver, kidney, muscle, bone marrow.

Finding out find out why some areas of the brain, like cerebrum, striatum and hippocampus do not have age related changes in gene expression, thus might be absent changes in protein composition and actual function, happen could cause drugs or medical treatments that cause the rest of the brain to be absent deleterious change with time. Find out why parts of the brain are sort of genetically ageless, then port that to the rest of the brain.

Another grouping of cytes/tissues that might have shared longevity action (drugs, genetics, other technologies) that have addressability: What about the 3 mesoderm, ectoderm, someotherderm tissue types at a fetus; It is possible these types, and the differentiated tissues that arise from them would share meso/ecto/some derm type longevity/healthspan effective drugs or biochemical mechanisms at the born human’s tissue based on the types of tissues these embryo tissue types differentiate into. At something like the 16 types of tissue GEDFAM study they could find out if batching on ecto/meso/somethingDerm elucidates areas with simultaneous “coordinated” response and also responsiveness to new drugs. (something like: develop a longevity drug for the ectoderm system, works on all the differentiated tissues that started as ectoderm)This supports creating new technologies to create greater longer lifespans and greater longer healthspan.

I can imagine that the mathematics of finding how far up the sequence: genes->proteins->computational system-like statement of interactions, “omes” ->amount of product chemicals physical location and duration and their cycles ->youthful phenotype you have to go to find greatest areas of prediction ability at mouse to person-benefitting research. Finding out where at that system mice are most highly predictive would benefit the production of many other medical products and new technologies, possibly including brain-based technologies like learning and entertainment technologies as well. They could do research on what mice predict at humans very effectively, and then spontaneously think of new ideas that utilize that area of very effective prediction. This is beneficial at longevity and healthspan research.

I think the pubmed article or some other one makes it possible to figure out which proteins are being produced at increased or decreased amounts from the genes active at chronologically aged tissues, at that group of tissues where expression changes. That suggests that something like interference RNA could decrease proteins hyperproduced at aged cytes (from hypertranscription), or just possibly upregulate those that are produced less. Encouragingly I read during 2019 AD that the FDA had approved 30 RNA drugs thus far, so new RNA drugs that address the changes to gene expression between young and old cytes and tissues could benefit from established commerial viability and established engineering methods.

At the 16 tissue GEDFAM study it says that whether cytes and tissues change the amount of their gene expression simultanously at a coordinated pace is numerically discernable, “a mouse may contain many tissues with high apparent ages (represented by high fractional scores) and thus generate a very high overall aging score. Conversely, another mouse may contain many young tissues and generate a very small overall aging score” and, “At 6, 16, and 24 mo of age, we found that there is coordinate aging of different tissues”…”The group of 24-mo-old mice showed the most coordination of aging among tissues.”

New longevity and healthspan drug: So among the tissues where genetic expression quantity showed change with chronological age (9 did 7 did not), the coordination that the researchers found may suggest a synchronization process or biochemical that affects many systems simultaneously. That could be the object of a new drug or therapy that phenotypically youthifies and reduces the age related 200-800% changes at gene transcription at several tissues simultaneously.

It could be that making drugs that effect the multi-tissue coordinator system (and/or circulating chemical) could also keep gene trasncription, and the protein products that make up the organism, at the linear no-wild-swings area of the youthful phenotype. There is a chance that running the body on mild rather than 800% different transcription amount reduces perturbations across many systems; that could possibly benefit wellness. Although I do not know a specific mechanism of how, I perceive that in engineering if you run a mechanism near the middle of its specifications it works better longer. But there are no specifications at an organism.

It might be possible to desynchronize these coordinated deleterious aging systems, such that some of them age more slowly, increasing healthspan and lifespan. “desynchronization” might sound iffy, but if it causes younger tissue, or excludes some cytes and tissues from an “age program” or an aging chemical’s activity then there is benefit. As these tissues are physically distant from each other there may be a circulating chemical that coordinates aging and youthfulness. If there is a circulating chemical that coordinates aging, then the 16 tissue study having brain parts that variously have chronological age effected differential gene expression that is coordinated, and also non-coordinated non gene expression-changing brain tissue could be a basis for finding out what the difference in susceptibility is.

At the 16 tissue types paper: That some parts of the brain have coordination of changes at the amount of gene expression with aging while others are absent aging related genetic transcription change suggests that a protein or chemical crosses the blood brain barrier. I read that some parts of the brain have more blood brain barrier than others, which might or might not be relevant. If that circulating chemical or protein, or even peptide can be found, it could be possible to engineer something that fits into the same protein or chemical transport structures at the cytosurface or at receptors without activating them, blocking the age synchronization chemical. It is possible this age-coordination effect blocking chemical might concentrate differently at different tissues to disrupt coordinated aging.

Compare all the protein transport channels on the outside of the coordinated aging tissues with those at the non-changing-expression-with-age tissues; those receptors’ difference suggests the kind of protein, possibly even points to a particular protein or chemical that some of the tissues respond to with coordinated aging and the other youthful gene expression tissues do not;

Being almost the same tissue, the cytosurface differences between the aging-coordinated and non-coordinated brain areas’ tissue might be minimal, so there is a simpler set of membrane surface groups and transport channels to compare to each other to find the circulating gene-expression coordinator. Comparing membrane transport mechanisms at the cytosurface makes finding the identity of the transported aging chemical easier.

They could also try electricity and electromagnetism to modify genetic expression changes at aging cytes and tissues. Yeast are published as responding to electromagnetism; voltage potentials across cytes and tissues exist, tDCS effects neurons at a multi centimeter distance with slight voltage and current. Electrical or electromagnetic modification to the biochemistry of coordinated aging at the published tissues, and others, could be a beneficial scientifically and engineering technology rigorous therapy and aging preventative. If it works.

Noting the tissues and cytes without a [coordinated gene response to chronological age] may also be receptive to a new circulating chemical that causes less “gene transcription expression change ”; that chemical could then be a longevity anti-aging chemical. A panel of molecular variants of things that do something similar, but different than, the possibly-findable gene expression coordination chemical, could be screened to find out if there are any versions that are active at the aging-gene-expression tissues/cytes to make them not change thier gene expression with aging, youthifying them.

What might have been called “non-coding regions” of DNA near 2019 AD could be researched to see if they have any effect on aging, longevity and healthspan. At the 16 tissue study, the gene expression comparative studies, to my perception, concentrate on active genes, which might be called exons. I read about noncoding regions, and that they actually do things, and something like the 16 tissue study could find out what coordinated genetic expression at: chronologically aging tissues genes’ cytes/tissues as well as the nonresponsive to chronological aging genes cytes/tissues Do with the effects of noncoding regions. The noncoding regions could have an effect on

wikipedia says, “Other functions of noncoding DNA include the transcriptional and translational regulation of protein-coding sequences”

Doing things with drugs, gene therapy, eugenics, genetic engineering or therapy to the noncoding regions of DNA could create some new drugs and therapies using things like interference nucleotides (iRNA). Also drugs that effect noncoding regions modify transcriptional and translational regulation, so it imaginable that noncoding DNA interventions could be engineered for longevity, healthspan and lifespan purposes. Modifying noncoding DNA with gene therapy or genetic engineering, or possibly even epigenetic mechanisms could changes the transcription and translation of genes that change their expression amounts with chronological age; beneficially modifying the noncoding regions to create greater lifespan and healthspan. Some of the genes that change their expression with chronological age are described at the 16 tissue gene expression study.

Epigenetics of different gene expression at those genes that are differently transcribed based on chronological age is a longevity drug and/or therapy approach as well. One of the paper URLs notes 200-800% change in the amount of gene trascription depending on the chronological age of the mouse at brain or liver. If epigenetics can modify 500% to be 200% it could be a longevity/healthspan drug or therapy. This could also be a prenatal or childhood epigenetic practice or chemical beneficial thing to do. with epigenetics it is possible a brief exposure to something beneficial could have lifelong benefit. The epigenetics of differential expression of genes during different chronological ages is an opportunity to find things people can do to live longer and have their children live longer weller lives.

Making one transcript per cyte genes into active high copy number genes to produce beneficial effects. Wikipedia https://en.wikipedia.org/wiki/Non-coding_DNA says, “They noted that 70% of the transcription coverage was less than 1 transcript per cell. They noted that this "larger proportion of genome with reproducible but low biochemical signal strength and less evolutionary conservation" That suggests that there are lots of genes that code for proteins where only one protein molecule is produced. Those transcribed yet one molecule genes represent a vast library of genes that can be easily addressed. Perhaps some of these 1 transcript genes can have their output vastly amplified with drugs or epigenetics. Then something like mice, prior to humans, can be a guide to what the effect on the phenotype is. Example: a mentally ill person has a 1-transcript-made gene producing the peptide relaxin-3, or better an actual antidepressant antianxiety protein, which treats depression and anxiety, Then the person does an epigenetic thing or takes a drug or has a therapy that ups this to billions or trillions of produced protein molecules. That raises their amount of relaxin-3 and they feel much better and bring greater happiness to others as a result of being mentally well. Technologizing these 1 transcript per cyte genes, treating them as a library of new capabilities that humans can activate, gives large amounts of new capability at human tissues and cytes. It is likely that using what wikipedia calls “non-coding DNA” as a library of new useable genes is well known out there already.

I think it is perhaps well described in preexisting literature, but artificial endocytotic DNA editors and even turing compatible computers made from protein and nucleic acids are a thing I think could be engineered. These would make it so people could customize their DNA at every cyte any way they liked.

A very effective appetite supressant drug could be a longevity drug from reducing appetite so much that caloric restriction is effortless. Fen-phen was recalled after cardiac events, but it is possible that sensitivity to fen-phen could be predicted, possibly with genetic screening, making it functional for a larger part of the population, perhaps people with minimal family history of heart disease. Also, the years of life gained could be much higher than the years of life risked at an appetite supressant drug, possibly even fen-phen. Of course the numeric advantage, if any, of the appetite supressant drug only occurs if the person keeps it up. A better version of fen-phen could be developed that makes eating 40% less (longevity producing caloric restriction) effortless. I think I read the euphoriant MDMA was considered as a diet drug. I do not know if it is appetite supressing or not. If it is, some molecular variant could make people feel good, adjustable from nice to really high, to fit with their preferred lifestyle that causes greater longevity and healthspan benefits.

A larger numeric quantity of mitochondria sustain energy levels at cytes, from what I read, this permits the full range of proteins to be produced, as compared with a different less optimal group of proteins producible if there are fewer mitochondria. This effect might extend to ribosomes as well; does having more ribosomes at a cyte produce more proteins more easily, promoting wellness. Do ribosome quantity change with time? If so, drugs or other medical therapies that increase the actual number of ribosomes at cytes and tissues could improve wellness from having young organism protein production amounts. Supporting more ribosomes is better is, “Genes in the cytosolic ribosome set stand out as the strongest age-related difference in expression between tissues.” from the 16 tissue paper.

The 16 tissue paper seems to describe 9 tissues that have strong gene expression changes at different ages:

cerebellum, eye, gonads, heart, lung, spleen, spinal cord, thymus. Then it mentions 7 tissues without much change in gene expression: cerebrum, striatum, hippocampus, adrenal glands, liver, kidney, muscle, bone marrow.

Editing mitochondria of existing people with CRISPR/possibly variant Cas9: “Comparisons of transcript profiles of aging among human, mouse, fly, and worm have shown an overall decrease in the expression level of the electron transport chain genes in these distantly related species [10,13]. The mitochondrial electron transport chain” also, “only one gene set (the mitochondrial electron transport chain gene set) was commonly age regulated in all four species, showing an overall decreasing trend in expression in old age”. I read that crispr/cas9 works at editing mitochondrial genomes. Editing, to youthify mitochondrial genomes and/or replace them with a more optimal longevity and healthspan increasing version is a possible medical activity. They could look at the mitochondrial genomes of supercentenarians and then see if their versions correlate with greater longevity at a different measured sample. Then those could be the human compatible new version to make with the edit; a better edit would be a completely new mitochondrial genome.

GSK longevity technology; inerference rna youthifying beauty topical drug that sperately addresses each of the (I think listed on pubmed) things that get downregulated or upregulated in skin aging. So like a ten peptide topical drug. The youthifying topical drug not only youthifies it causes greater general knowledge of youthification and anti aging technology

I have heard of methylation and ethylation, there is also phosphylation of proteins, “Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function.” Wikipedia suggests it is a protein activator, “For example, if amino acid Serine-473 ("S473") in the protein AKT is phosphorylated, AKT is, in general, functionally active as a kinase. If not, it is an inactive kinase”

Approximately 13000 human proteins have sites that are phosphorylated”. Further, “It is estimated that 1/10 to 1/2 of proteins are phosphorylated (in some cellular state)” with 1/10 to half of all proteins phosphorylated,

What effect does modifying the amount of phosphorylation have on the body? Are phosphorylation modifiers, possibly those that concentrate at particular proteins, cytes or tissues, already an area of medicine; wikipedia has an article but does not list any specific proteins at “phosphoprotein”.

GSK: phosphorylated versions of already successful drugs might work even better, and be a massive new quantity of products generator; wikipedia says, “phosphorylation. This enables proteins to stay inbound within a cell since the negative phosphorylated site disallows their permeability through the cellular membrane.” suggesting phosphorylated protein drugs or even smaller organic chemicals could have tissue localization. Wikipedia also mentions that bacteria have a like phosphorylation membrane, then a space, then an avoids-transporting-phosphorylated-molecules membrane, that causes the chemical to concentrate at the cytoplasm. Could concentrating at the cytoplasm improve drugs effect or potency, like at neurons, could drugs concentrate more at dendrites or axons or the big blob at the middle of the neuron; that could benefit psychiatric drugs and recreational drugs. Not supporting this: the thing is that phosphorylation is just putting a PO3 on another molecule, so it is likely tht at most drugs they have already thought about putting a PO3 on it if it was thought to have utility.

[[Thinking of non protein non peptide (often organic) chemical drugs, is there a particular phosphorus containing moeity that makes a nonprotein molecule act like a phosphorylated protein at the body? wikipedia says a phosphoryl group is PO3 could you put that on other drugs, like, replacing a nitrogen with a phosphorus?]]

There is a blunt idea out there that a different amount of general methylation or different ethylation has preferrable effects on the human body, perhaps at certain ages, is there a similar mass-blunt approach to viewing hightened or decreased phosphorylation as “generally beneficial”, or perhaps “reducing phosphorylation is beneficial”? That suggests new phosphorylation promoting or decreasing supplements and genetic modifications.

However, the internet says too much phosphorus at dietary food is mildly bad for people.

I think wikipedia might have communicated: Tyrosine phosphorylation is fast to react and the reaction can be reversed. Being one of the major regulatory mechanisms in signal transduction - cell growth, differentiation, migration and metabolic homeostasis are cellular processes maintained by tyrosine phosphorylation.” Also, “In eukaryotes, protein phosphorylation functions in cell signaling, gene expression, and differentiation”

Noting cell growth, migration, differentiation effects of phosphorylation, would modifications to phosphorylation benefit fetal development during pregnancy, benefitting the children; are there any foods, possibly a quantity of a phosphoprotein, or studied as harmless during pregnancy things that modify phosphorylation, possibly increasing it. Or possibly decreasing it; it could be that more gradual migration or growth produces finer placement of tissue or better constructed tissue.

If phosphorylation benefits the fetus, perhaps the bacteria at a maternal probiotic could produce a phosphorylating chemical, like a phosphoprotein that reaches the circulation;

Towards a beneficial phosphoylation source: Noting that phosphorylation actually happens to body tissue proteins when a phosphoprotein (wikipedia) gives them a PO3 phosphoryl-ness. The phosphoprotein gets its phosphate group from post-translational modification after being produced as a protein at the ribosome. So a chemical or drug that modifies posttranslational modification that puts on the phosphoryl group could increase the amount of phosphorylation as an enhancement if phosphorylation is beneficial; there is possibly some way to reduce the posttranslation modification that puts the phosphoryl group on if less phosphorylation is beneficial

They could screen humans for phosphorylation producing genes and SNP differences and compare the wellness and well being of the different types, including pregnancy and well baby outcomes. That might suggest a quantifiable amount of phosphorylation to do to optimize people’s lives.

Not knowing what it does, but thinking that a different amount of phosphorylation could be beneficial, noting that wikipedia says, “suggested that the acetylation of histones can stimulate transcription by suppressing an inhibitory phosphorylation”. I may have read that the more histones the greater resistance to mutation and the more gradual the production of proteins. So more phosphorylation might increase tissue quality and reduce risk of cancer; I have no idea though.

Previously I typed as if a surplus of phosphoryl groups at the body might cause more phosphorylation generally, which could be beneficial, or could be beneficial if reduced. It now seems different than that. Some of the previously written material is in brackets [[ that mean “ignore the material between brackets”

[[It is not looking like it would phosphorylate other things, but phosphorylated arginine combines the baby birthweight increasing amino acid arginine with PO3 to make a more-likely to be assimilable source. Noting that wikipedia says the phosphoprotein travels around giving a PO3 group to amino acids. Things likely do not function to make a PO3 amino acid like phosphorylated arginine and then think it could phosphorylate other amino acids. Uridine monophosphate also exists. It is in breast milk and makes lab mammals do better on cognitive measures.]]

The internet says too much phosphorus at dietary food is mildly bad for people.

[[However, it seems possible that eating a smaller amount of a phosphorylating molecule or food could maintain the amount of phosphorus in the harmless range. If bodywide phosphorylation is beneficial can you just eat PO3 reacted sucrose, which might, but likely does not, taste good.

phosphorylating preserved cabbage. Tastes strange, but might be tasty.]]

[[I think I read something about uridine being beneficial, so uridine PO3 could be beneficial as well. Uridine monophosphate (UMP) is a lab mammal cognitive-benefitting supplement; wikipedia says, “UMP (1 mmol/kg), a constituent of human breast milk and infant formulas”. UMP already has a P(OH)2O on it, so three oxygens and a phosphorus. Perhaps a modification to cause UMPs digestion products to leave a phosphorylating molecule that reaches the rest of the body after oral ingestion and digestion, would create a phosphorylator that still benefits cognition; UMP benefits cognition at lab mammals.]]

dioxyphenyl group might or might not be even more effective at crossing blood brain barrier than phenyl group or clorophenoxy group. An amino acid linked to it is a brain drug suggesting concentration at the brain. Could be a localization chemical group at some brain areas or neuron types as well. <8><=> It is possible to imagine attaching it to a nootropic like instend of phenyl at phenylpiracetam.

As to keeping molecules on the body side my perception is that making something hydrophilic keeps it on the body side of the blood brain barrier. Putting phosphate groups on the molecule might do this because at proteins phosphylation makes the proteins hydrophilic.

GSK: oral peptide drug improved absorption tactic/strategy: lipophilic and hydrophilic cause different tissue transport/concentration, is there some chemical group that could be added to a peptide to make it GI-tract interior “skin”/dermis passable? Besides things like ion channels or protein transport thingies, possibly local vasodilators, topical niacin might be vasodilator so niacinimide group attached to peptide or protein drug might heighten absorption and passage at at GI tract “skin” some. Also, Do any enzymes facilitate peptide/protein transport at GI tract “skin”? They might change the actual shape of the transport channels on the outer cytomembrane. So a blend of enzymes and peptides would have the enzymes reshape the ion channels and protein channels making transport of the peptide drugs easier.

I have not heard of phosphorylated peptides as drugs. When proteins are phosphorylated that have greater activity, “if amino acid Serine-473 ("S473") in the protein AKT is phosphorylated, AKT is, in general, functionally active as a kinase. If not, it is an inactive kinase”

April 4th, 2019 more public domain ideas:

longevity technology

wikipedia: “previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change (by log-rank test) in both sexes, with larger effects in males, consistent with the original report. There were no significant differences among the three doses. The two higher doses produced 16% or 17% increases in median longevity of males, but only 4% or 5% increases in females. Age at the 90th percentile was increased significantly (8%-11%) in males at each dose, but was significantly increased (3%) in females only at 1,000 ppm.

They should make a beauty increasing probiotic. LKM512 or other spermidine producing probiotics are one possibility as it makes mice have comparatively luxurious coats. A probiotic quantitatively measured as boosting collagen and elastin production could also be beneficial. Probiotics could also be bred, or genetically engineered, to concentrate minerals like zinc or Se from the culture medium. pubmed says, “Rats were intoxicated with sodium selenite (0.3 mg/kg body wt.) for 10 weeks. An increase in total collagen content in skin and a decrease in the lungs, liver and kidneys were observed. Enhanced serum and urine levels of collagen metabolites were found. Elastin content was shown to be increased in the lung, liver, heart muscle and kidney of selenium-intoxicated rats” Supporting Se as upping collagen and elastin production.

It is unknown to me if the variety of previously topical beauty peptides can be absorbed at the colon; if so, then probiotics engineered to produce beauty peptides could youthify skin.

pubmed says, “ (coenzyme Q10 + grape-skin extract + luteolin + selenium) were administered to volunteers (n = 41). Skin properties (moisture, elasticity, sebum production, and biological age) and ultrasonic markers (epidermal/dermal thickness and acoustic density) were measured thrice (2 months before treatment and before and after cessation of 2-month oral intake). The supplementation remarkably improved skin elasticity, sebum production, and dermal ultrasonic markers.” All of these things, perhaps notably Coenzyme Q10 or PQQ, could be made a part of probiotic bacteria.

Getting bacteria to produce amino acids is simpler than some other things. At a probiotic it is possible some amino acids have a skin and body preserving and/or enhancing effect. A few moments of looking online suggests hydroxyproline and cysteine: “Hydroxyproline peptides are not completely digested to free amino acids, and can be detected in the blood. This enables them to stimulate cells in the skin, joints and bones, and produce more collagen activation and growth throughout the body. Hydroxyproline has also been shown to protect body cells against glycation, which linked to premature aging”; of cysteine the internet says, “cysteine is a crucial part of the body’s process of protein synthesis and collagen production, as well as supporting detoxification, maintenance of skin elasticity and texture, and the possibility of diverse metabolic functions. Due to the roles it plays in body function, cysteine is sometimes taken as a supplement”. The internet says N-acetyl cysteine turns to cysteine in the body; n acetyl cysteine has published research where it causes greater longevity at laboratory mammals.

A variety of other beauty beneficial amino acids along with cysteine and proline are described online; three others are described at https://www.aminoacid-studies.com/areas-of-use/anti-aging.html another beauty beneficial amino acid is creatine, “Creatine stimulates endogenous collagen production. This allows the skin to connect more moisture, become thicker and have a smooth” appearance.

The thing is that there are about 120g of creatine in the body naturally, so a probiotic that produces 1-10 grams a day might only shift this 1-10%, however there is the possibility that creatine is produced by cytes at tissues where it stays, and that the amount of circulating creatine is notably less than that; it is also possible that the tissues that do not make all their creatine locally benefit from the circulating creatine, so for those tissues the plausible 1-10 grams of creatine produced a day at a probiotic could directly benefit those tissues.

Probiotics that produce collagen could benefit appearance, “Of the data available, a double-blind placebo study found that women who took the peptide form of collagen regularly for eight weeks saw a 20 percent reduction in” a measure of visible skin aging. Also there is research that supports, “collagen has been shown to support and increase the body’s hair building proteins, which can prevent hair loss, encourage hair growth”. So rich hair growth at the head could enhance beauty as well. Collegen is also published at scientific literature as making joints comfier, with improvements from 37% to doubling comfort. Probiotic bacteria could produce beneficial vitamins as well; of collagen the internet says, “vitamin C and collagen must be consumed together, since if you have too little vitamin C in your body, not enough collagen can be produced.”

Some fungi produce chemicals that cause greater longevity at lab mammals, perhaps those fungal chemicals could be engineered into a probiotic conferring both beauty and longevity.

ECGC is a green tea polyphenol, of green tea polyphenols the internet says, “Green tea contains polyphenols that boost the production of keratinocytes, thus slowing down the ageing process of your skin. Moreover, it reduces the extracellular matrix damage on your skin, thus eliminating wrinkles” Probiotics that generate polyphenols could benefit wellness as well as beauty.

Breed probiotic bacteria to have GI tract durability, make twice a month dosing practical. The antibacterial chemical component of garlic could possibly be made at a beneficial probiotic, reducing the number of competing bacteria, enhancing durability of the probiotic dose, “garlic has antioxidant, antibacterial”. It is possible, but unknown, that the antibacterial chemicals in garlic have some other wellness benefit thus improving the probiotics healthiness effects. Also, some lipids are antibacterial, “monoglycerides and fatty acids”. It is possible a probiotic that produces these would reduce competing bacteria at the GI tract causing greater intervals between doses. Another thing that could increase interval between probiotic doses is engineering or breeding probiotic bacteria to use the most commonly occuring nutrient by mass at the GI tract, that way there is a surplus of food, notably compared with competing bacteria, for the beneficial probiotic thus increasing its numbers.

Another thing that could increase the interval between probiotic doses is to engineer or breed more than one bacterial species to make beneficial chemicals, that way if something, possibly a day spent on one particular kind of food, reduces the amount of one kind of bacteria, the other bacteria are there to increase in numbers and maintain the level of beneficial chemicals. There could be different probiotics at a blend each having a food and reprosuctive advantage at a high lipid consumption day, a high protein day, a cellulosic high vegetable day, and a carbohydrate rich day. Also, the different probiotic species could be adapted to different fecal consistencies, with a large amount of watery runny feces favoring one multiprodcutive bacteria compared with overly firm feces favoring a different yet equally multiproductive bacteria as well as moderate normal feces favoring another kind of multiproductive bacteria.

Previously written/recorded is how motile bacteria, possibly like proteus, could be engineered to be both probiotic and also to swim upstream, basically always concentrating at the upper colon and possibly small intestine to generate a probiotic that is absent getting defecated out. That could increase the interval between probiotic doses.

Some lipids are not produced at the body so these could be produced at probiotics, Quora says, “linoleic acid. That is an essential fatty acid your body can’t produce by itself. It is also the most abundant fatty acid in your skin. People with a diet rich in linoleic acid has a lower likelihood of skin thinning”. Also I read about ceramides that are active at drug-sized dosages rather than macroscopic quantities, it is possible probiotics could make these beauty causing ceramides at drug dosages.

A longevity four amino acid peptide, epitalon, may also have beauty applications, “Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts”

Along with genetically engineering new probiotics it is possible that plasmid exchange could confer new genetic capabilities at probiotic bacteria just from co-culturing (perhaps with calcium chloride or something newer) the probiotic with another unrelated bacteria that has a beneficial product.

COX-2 (and cyclooxegenase (COX) inhibitors generally) reduce erythema from UV and aspirin/ibuprofen might be about SPF 2.5; there are peptides that inhibit COX so these could be produced at SPF probiotics that might also reduce risk of cancer. COX-2 inhibiting probiotics could be probiotics that reduces perimenstrual symptoms.

Probiotics that produce short easy peptides could benefit mental health, and possibly menstrual symptoms, “As of 2010, researchers discovered a natural peptide called “Spadin” comprised of 17 amino acids with potent, fast-acting antidepressant properties.” and, “The substance elicits its effect primarily by acting as a TREK-1 potassium channel antagonist.” and, “Mice with knockout TREK-1 channels have been noted as being immune (or resistant) to developing depression, and among non-knockout mice, administration of Spadin elicits the same effect as a result of its antagonist effect.” So spadin could be made at a probiotic and could also be studied as to its effects on the mentally well. Among the mentally well could be menstruating women and girls who might experience fewer emotional/mental symptoms during menstruation when they take the probiotic. If spadin is harmless or beneficial to the mentally well then taking the probiotic indefinitely and/or all month could reduce menstrual symptoms while providing actual, seekable, other benefits. Another possible antidepressant peptide that could be made at probiotics is CART peptide, “there is interesting evidence that CART peptides play a role in anxiety and depression, and that CART peptides may be endogenous antidepressants.” Once deemed safe or harmless, CART could also be energy producing, stimulating and fun, providing a tangible reward for taking the probiotic. At probiotics his might be a new energizing life-improver equalling or surpassing coffee. Laboratory mammals are more energetic on CART.

CART causes laboratory mammals to make more BDNF (brain derived neurotrophic factor), “CART peptides have been shown to increase BDNF mRNA in hippocampal neurons [63].” More BDNF could go with increasing intelligence and possibly adaptability. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137165/

The research URL mentions that people with messed up CART genes experience obesity, so it is just possible that a probiotic that produces CART could cause beneficial weight loss among the well.

Another antidepressant peptide that could be made at probiotics is D1-D2 interfering peptide, “After identifying a 15-amino acid sequence within the third intracellular loop of the D2 long receptor isoform, Pei et al (2010) designed a 15-amino acid peptide that is able to disrupt this interaction both in vivo and in vitro. Furthermore, the D1–D2 interfering peptide has an antidepressant effect in the forced swimming test (FST) and the learned helplessness (LH) task, two preclinical tests for antidepressant efficacy” https://www.nature.com/articles/npp201461 . One thing that people might value is that the rodents’ forced swim test is reminiscent of human intention to persist until success, something many people value about themselves and would appreciate even more of. This peptide could be a successtropic as a probiotic.

Duration of D1D2ip could also favor probiotic delivery, “D1–D2 interfering peptide has a significant antidepressant effect in the FST for up to 2 h after IN administration” Two hours is not much. One advantage probiotics have over intranasal delivery is continuous availability, one non-advantage is dosage variability based on number of fecal evacuation events a day as well as fecal consistency. Addressing that could be to have all three of the lipid/carbohydrate/protein or the liquidy/firmer than preferred/normal feces bacterial types. The spread effect of the bacterially responsive probiotics makes some peptide at each bacteria for an averaging effect

That these three peptides can improve mental wellness supports mental wellness probiotics as well as mental wellness gene therapy.

Some lipids are antibacterial, “monoglycerides and fatty acids”, also, “to produce LNCs with antibacterial activity by replacing lecithin with other lipophilic surface active compounds, namely medium-chain fatty acids and their 1-monoglycerides, which are known to have antimicrobial properties.” It is possible that at a body surface probiotic these could cause clearer skin from the antibacterial effects.

A way to improve probiotics, among them beauty increasing probiotics, is to find out if it is possible to time or situationalize their production of beneficial chemicals. Some pills taken either with food or on an empty stomach work better. I perceive the solitary drug effects of amino acids are stronger if taken without a protein meal. The probiotic bacteria could sense recent meal, and possibly time of day, to release beneficial chemicals when they were at their most beneficial. Meal detection might come from the probiotic bacteria sensing glucose at the walls of the GI tract, and time of day might be associated with the morning defecation reflex being a certain number of hours ago.

A nifty area of research could be if when probiotic bacteria wear out, do their lipid membranes, as well as any cytoplasm content get absorbed at the GI tract; it could be that they just get defecated out. If cytoplasmic or membrane components are meaningfully absorbed then engineering bacteria organelles to produce beneficial chemicals could be easier, and have well beneficial known/well defined genetics, than than engineering bacteria to secrete beneficial chemicals to the environment.

A beauty producing yogurt might have greater additional popularity than usual. A dermal body surface probiotic could also be a beauty probiotic.

Longevity/slimness idea: order more metformin online then take twice a day; 12 lb annual weight loss from metformin makes longevity effect even more appealing. Leave morning dose of metformin and fish oil next to bed for more consistent morning use. Consider Se (higher selenium levels had a 48% lower incidence of advanced prostate cancer), also Se: “Low serum levels of selenium are associated with reduced survival in elderly”, however: “longevity promotion under conditions of Se deficiency may be attributed to 1) stress-response hormesis, an advantageous event of resistance to toxic chemicals at low doses; 2) reduced expression of selenoproteins with paradoxical functions”, magnesium, COenzyme Q10/PQQ, lutein (lutein are 43% less likely to experience macular degeneration) supplements, ECGC (green tea chemical); possibly LEF multivitamins.

CART peptide may be available online, along with being an antidepressant, CART could cause beneficial weight loss among the well.

Another antidepressant peptide that could be made at probiotics is D1-D2 interfering peptide, “After identifying a 15-amino acid sequence within the third intracellular loop of the D2 long receptor isoform, Pei et al (2010) designed a 15-amino acid peptide that is able to disrupt this interaction both in vivo and in vitro. Furthermore, the D1–D2 interfering peptide has an antidepressant effect in the forced swimming test (FST) and the learned helplessness (LH) task, two preclinical tests for antidepressant efficacy” https://www.nature.com/articles/npp201461

Easy foods that might be beneficial: instant bean/legume soup, olive oil, “Researchers concluded that the monounsaturated fats in olive oil were largely responsible for the low rates of heart disease and cancer”

Schizophrenia: see if low doses, perhaps 500 mg of phenibut reduce voices. 3-4 times a week; this could go with less latuda, thus improving alertness and energy

GSK: There are fat-blocking pills, possibly chitosan; could there be a sucrose-absorption blocking drug or even food that reduces absorption of sucrose so that GI tract bacteria process it instead, producing less harmful/beneficial volatile fatty acids? It is possible that something different than, but a little like prilosec the proton pump modulator could reduce the activity of transport channels at intestinal cytes. Also, an interesting possibility is gene therapy to make the endothial layer of vascular systems as well as capillaries 50% less transporting of sucrose/glucose. That could have healthspan as well as longevity benefits.

Technology:

At trehartz imaging, “silica-coated GNRs [gold nanorods] showed higher photothermal efficiency caused by the localized surface plasmon resonance that increased the terahertz reflection amplitude” The interesting thing here is that a silica coating can have plasmon effects; that suggests that doped silica or Si coatings could have customized plasmon response at particles; Are there organic coatings, possibly starches or carbon dust/graphene that effect plasmonics of objects like particles?

A custom carbon plasmonic dust could be a cheap gasoline additive that effects octane number.; Does a plasmonic surface have different wettability or lipophilicity? Possible application to windshields, windows.

Along with imaging this could be used for

possibly medical uses: do surface plasmons from custom coatings, possibly carbohydrates, effect drug delivery or nanoparticle uptake by cytes? If so that could heighten effectiveness of anti-cancer drugs. Wikipedia says Plasmon surface imaging can see carbohydrates because of their unique plasmon light absorption effects, so carbohydrates may have tunable plasmonic effects. Also supporting plasmon-customized carbohydrates at wikipedia is, “For this, a bait ligand is immobilized on the dextran surface of the SPR [surface plasmon resonance] crystal”

Do plasmons occur internally at materials? whether purposefully built to have layers or also natural crystal boundaries, like at crystals in cooled metal or fractured iceland spar.

Petroleum geology (petroleum refining) technology: custom Plasmonics can tune the absorption frequency of radiation at a material; could a catalyst be plasmon customized to be more effective, thus upping efficiency of oil-to-gasoline (etc) product plants? (note: there are web pages on plasmonic catalysis) My perception is that plasmonics has to do with electron hole pairs that migrate together, which sounds like it could effect the electron-field of a catalyst material. Does light stimulated plasmonics work on the high ambient IR at catalytic cracker temperatures? online it says there are IR plasmonic things.

Does plasmonics, notably plasmonic catalysis, work even though it is in a fluid? Regarding composition of the plasmonic-enhanced catalyst, “Typical metals that support surface plasmons are silver and gold, but metals such as copper, titanium or chromium have also been used” and a plasmonic catalysis web page mentions “Catalysis with Earth-abundant Metals” and another page says, “US researchers have produced nanoparticles comprising a plasmonic core that can absorb light, surrounded by a shell that acts as an effective catalyst.”

and, “[before the plasmonic catalyst] the gas mixture had to be heated to over 200°C before the carbon monoxide was oxidised, and the selectivity for carbon monoxide was barely 10%. With illuminated [1 nm coating thickness] platinum-coated [Ag] nanoparticles, however, the photo-reaction occurred with around 70% selectivity at temperatures as low as 130°C.”

At non hole-electron systems, could the bright IR at a catalytic cracker promote a reaction:

Lenticular printing is that grooved multi-angle visual thing; could the sides or trays of a petroleum refining reactor have macroscopic, durable grooves (similar to lenticular printing) a little like fresnel lens that retroreflect IR to a new far angle, distributing heat and possibly acting as a reactor thermal insulator, reducing heat loss could make refining cheaper.

At visible light white non-specular reflectors (white non-smooth tile) increase illumination at near areas; could nonsmooth IR reflective white-like surfaces increase IR and warming at near areas?

At bubble trays and bubble caps is there a reaction-friendly viscosity modifier (possibly reintroduced lighter weight hydrocarbons) that makes them bubble more readily? Should they bubble differently? Whay not just change the geometry of the tray or the mass of the bubble caps?

Gasoline is transparent and has a specific refractive index; could reflected IR travel though transparent gasoline until it reached unreacted hydrocarbons with different absorption spectra even though it is similar to a homogenous mixture? Doubtful, except at really gooey transparent hydrocarbon with nearly-asphalt regions of a catalytic cracker; the light could pass through until it reaches a carbon particle where it absorbs and makes warmth.

Petroleum geology technology: Spring loaded bubble caps generate electricity, then the electricity causes the catalyst to be more effective from changing surface charge. Bubble caps lift and rattle; attaching a magnet to them, or a piezoelectric coating or ceramic, could make them generate local electricity, which could be used to modify surface charge of catalysts plated onto the bubble caps or catalyst dissolved in the petroleum fluid being cracked. Piezo-catalysts are described at some web pages.

Could a thermally cooler catalytic cracker use light, produced at >70% efficient LED semiconductors (which also make some reaction process warmth), to activate catalyst function at lower temperatures?

Medical:

Effect of CO2 enriched water on skin: “indicating that an increase in skin blood flow improves endothelial-mediated vasodilator function”, also, “CO2-rich water-induced large increases in skin blood flow may improve endothelial-mediated vasodilator function while causing less heat stress.” That brings up the possibility that at the interior of the body things that increase blood flow could benefit many tissues. Excluding things like high blood pressure, does elevated pulse cause better tissue blood flow? What about normal blood pressure blood volume per heartbeat (perhaps called ejection volume)? Things that increase blood flow safely could be a group of healthtropic drugs that improve circulation. There are some niacin related things, but these have perceptible sensation even though they might effect internal-to-the-body blood flow. Xanthinol nicotinate is one, but it feels weird.

GSK: On the possible technology is a drug or probiotic that reduces sugar uptake at the gi tract increasing healthspan and possibly gets around patient noncomplaint diet approach to reducing diabetes; possibly like a proton pump inhibitor but a glucose/sucrose pump inhibitor; Some proteins glom onto carbohydrates, so these could be carbohydrate-at-meal reducing drugs, “carbohydrate-binding proteins concanavalin A (ConA) and jacalin

MWI test/technology”. It is possible a probiotic could make these proteins if any carbohydrates are still absorbed at the colon (they might not be).

GSK: A novel kind of probiotic could be a detoxifying probiotic that specifically metabolizes something that is deleterious to human wellness. The ability of the engineered probiotic to eat/scavenge something like nitrates or nitrites could reduce cancer risks. Also, less methionine is linked to longevity, I do not know how much methionine gets absorbed at the lower GI tract, but if there is any of it the detoxifying probiotic could eat it, removing it from absorbability. It is unlikely, but a probiotic bacteria that eats alanine, if there is any at the lower GI tract, could reduce blood sugar, “The alanine aminotransferase reaction takes place in reverse in the liver, where the regenerated pyruvate is used in gluconeogenesis” Also, feces might be defecated for a reason, perhaps there is something in feces the body would actively like to get rid of; if so then a probiotic that neutralizes that thing would reduce reabsorption of the thing-to-be-gotten-rid-of.

GSK: At beneficial peptide delivery, one advantage probiotics have over intranasal delivery is continuous availability, one non-advantage is dosage variability based on number of fecal evacuation events a day as well as fecal consistency. Addressing that could be to have all three or six of the lipid/carbohydrate/protein or the liquidy/firmer than preferred/normal feces bacterial types make some of the peptide, but not all. The spread effect of the bacterially diet and fecal consistency responsive probiotics makes some peptide at each bacteria for an averaging effect. I am not aware of any previous existing probiotic group balancing effect.

Antioxidants are described at research; does skin, being on the surface, right next to oxygen, benefit more than other tissues from taking antioxidant supplements? Is there any benefit to lungs as well? Along with a body surface probiotic producing antioxidants it is possible a lung bacteria probiotic could be beneficial.

Noting the many beneficial things that can be engineered into probiotics I think these and other beneficial things can also be genetically engineered into grass, that way almost anyone, anywhere in the world can grow enough grass, which eaten periodically, provides numerous benefits.

GSK: Piperine amplifies the effect of other organic chemicals at the body, one example is curcurmin with piperine to produce an order of magnitude greater function. So the technology is: feed mammals piperine alone, then see if it improves wellness and healthspan from amplifying the effects of endogenous biochemicals as well as beneficial chemicals at food. If it does this (piperine alone) could be a new supplement. Noting GSK’s analgesic proft centers, perhaps piperine causes COX-2 inhibitors to be more fully absorbed, or perhaps decreases the time to feel better from more rapid absorption; that way an unchewed pill might work as fast as a chewed pill. Also, I read that older people absorb fewer nutrients from food. It is possible that piperine cause greater absorption of vitamins and phytonutrients from food such that older people would benefit from a piperine supplement.

Electrosurgery is a thing where they use RF to heat tissue to reduce or block bleeding or zap tissue out of existence; it uses a handheld thing that looks like a pen. It is possible that a camera-based electrosurgery wand could use AI/software/deep learning to estimate what the surgeon wanted to accomplish, image and compute the tissue, and then deliver just the right dose to staunch bleeding or zap away tissue. They could quantifiably measure this as reducing variability both amonst surgeons and at any particular surgeon, that translates as optimization of surgery. Robots with that software, even if developed for humans, could be superior at a larger number of medical procedures with variation minimized electrosurgery.

MWI technologies/MWI tests:

Technology:

I have not previously heard of software that attaches a camera to a human used tool then has software/AI/deep learning that has a model of optimal tightening, prying, lifting, or positioning or other actions such that the objects are most optimally adjusted. This is also an opportunity for the software to learn what the humans do at a multitude of actual contact points, such that the computer learns the distribution of the human efforts, and can then duplicate these at the modal, or better than modal, human value of tightening, prying, lifting, positioning, or other activity using automation or robots. The benefit to software steered human activities is better numerical control over actual product manufacturing and thus quality improvement. At the human, the human might notice that the software could make the tool have a soft bendy handle to avoid overtightening, or illuminate something like a spirit level, or its digital equivalent, to emphasize on-specification orthagonality at a complex part meeting another. Among many applications welding, gluing or screw positioning could be computer mediated to produce an optimal narrowly distributed new statistical mode that reduces variability at the actual product.

Towards a plasmonic technology that can work in fluids, even conductive fluids. my perception is that the electron hole pairs on a metal plasmonic device would be disrupted if the device were immersed in a fluid, especially a conductive fluid. It is possible there is some material where the electron hole pairs, although mobile, are hyper durable or topologically unable to leave the plasmonic surface. Some possibilities for a liquid compatible plasmonic scanner/emitter are:

Silver, the most conductive metal; At electricity math I have seen, multiple conductive pathways split the voltage yet silver is always more conductive than the competing fluid, ensuring some electron movement to go with the holes, which might be at a conductive polymer.

It is possible that the holes might move very gradually at a polymer, notably a conductive polymer, or even a proton conductor like proton conduction membrane polymers. so the silver splitting the voltage but always having some electron movement because of its higher conductivity, and the long-durations of hole movement could create a plasmonic device that worked when immersed in fluid. Regarding the polymer with the holes, it is possible a partially fluorinated version of a polymer, possibly a proton conducting polymer, could be electrically/charge neutral sort of like teflon, then that neutrality could keep the water molecules and any solutes at a distance; that permits the electron hole pairs to move together without actually being near solute/solution molecules. If measuring the fluid, the distance could be customized to have partial overlap permitting some interaction, but not enough to wipe out the plasmonic electron hole pairs. It is possible really narrow furrows at this teflonish possibly proton conducting polymer could keep liquid out from that microarea with something like surface tension

Then there is also the possibility of a few nanometers of some coating that permitted plasmonics to happen underneath it yet was a barrier to the fluid. I am reminded of the skinny partitions between quantum tunneling opportunities as flash memory. The overlayer could be so thin as to permit things like quantum tunneling while still insulating the electron-hole pairs from fluid based “electrical shorting”

Another possibility is to find a material with really robust electron hole pairs. I read about semiconductors based on elements that have activity voltages near three hundred volts as compared with silicon’s 1.5-5 volts. Only big energies can make those semiconductors semiconduct. So those same materials might have very robust electron hole pairs that are only responsive to big voltages; that suggests they could ignore the fluid’s electronegativity pulling electrons away from the plasmonic electron hole pairs.

Another possibility is to compensate the electron availability of the system, possibly dynamically. A reverse voltage bias neutralizes the current that “leaks” into the fluid, causing the electron hole pairs to remain in a zone of possible existence because the electrical effects of the fluid are neutralized with an external voltage source, or just possibly photonic light. It is possible something like a photovoltaic semiconductor plasmonic “stage” or reader/emitter could use light that would usually orchestrate the electron-hole pairs to also generate enough electrcity to produce an artificial neutral even if immersed in fluid.

I am really clueless, but is it possible that spin polarizing all the electrons at the electron hole pairs could make them stand out at something like a 10,000 sample-moments interpreter (computer circuit), despite the electron noise of fluid immersion? spin polarization is possible with lasers, so perhaps a two laser plasmonic reader/sensor could be possible.

Another possibility which seems unlikely, is magnetism. I have read about how diamagnetism can cause water to avoid a big magnet. it is possible a plasmonic reader mounted atop a big magnet would repel fluid enough to permit plasmonic processes even if immersed. It is possible this could have application making macroscopic objects weather-resistant, like atmospheric composition sensors.

It is possible someone who knows what they are doing could illuminate a plasmonic device from underneath rather than above at an angle like it shows in wikipedia. That would permit something like a plasmonic sensor as the top layer on top of a light emitting laser diode which does the illuminating, that is the hole electron stimulation.

Some applications of a plasmonic device that can be immersed in fluid are: 1) reading the molecules, possibly including isolated proteins at a fluid, like a bodily fluid, 2)plasmonic chemical catalysts that can work in an aqueous environment, 3) weatherproof/greaseproof chemical analysis and it’s robotic applications 4) new chemical microscopes that elucidate the chemical identity of whatever miniscule thing they are placed next to, like say a membrane lipid or a membrane-spanning protein. 5) at a human implement or a robot surgery implement a plasmonic tissue detector could work without a camera-friendly clear optical path to say which tissue was where, resulting in precise surgery even through bodily fluids.

Near april 8-10th, 2019

5b A camera/laser that views how a baby is sleeping, then directs a mechanism, like under the mattress bolster pillows that rolls gently so that the baby rolls to be face up, or if ok, side position.

Longevity technology some paper online suggests that some longevity drugs work by turning the crummy stuff down rather than turing the goodies up. Is there a separate group of longevity chemicals that cause greater longevity because they turn the goodies up? It is possible that the peptide epitalon is one of them; is it possible that something that makes more stem cells is one of them; NMN and NR could be an increased goody healthspan drug; another could be that at a graph of a bunch of genes that get upregulated or downregulated with aging; upregulating those downregulated from aging could be increasing a biochemical goody, possibly causing longer lifespan.

I do not know, but it might be that adding goodies is less technologically complex than mopping up, absorbing, or stopping the crummy stuff. Drugs, and gene therapy to make a goody chemical might, or might not, have fewer layers of abstraction, and even higher percentage yields from avoiding biochemical network steps, compared with a molecule or gene that turns down the production of another biomolecule or gene. Then again, perhaps just screening vast numbers of molecular libraries finds the “turn down the crummy stuff” molecules as easily as finding ways to turn up the goodies.

Is there a mass screening of libraries approach to things like small molecules, siRNA drugs, as well as at new genes for gene therapy, like ordered combinatorial progressions of gene SNP variants at varying each SNP location with a different amino acid, then testing them. The c elegans multiwell plates come to mind. Yeast at a million multiwell plate (1000 times 1000 locations) could also be beneficial as mass library screenings.

Rapamycin:

At the 23682161 paper it shows that rapamycin treated female mice sleep more than untreated mice; about 32 for untreated and 39 for rapamycin treated; that suggests an alarm clock could be part of human optimization of lifespan as sleeping 25% more could displace the cognitive moments from longer lifespan.

Rapamycin could be a slimness drug along with being a longevity drug. At one study, at male mice the average mass on rapamycin is published as 37 and nonmedicated mice at 47; that suggests 20-30% lower weight at the rapamycin mice. However at a different study looks like it is less than 5% different at the graphs. The thing is that a diet drug that causes greater longevity would be more beneficial.

Rapamycin dose frequency: https://www.ncbi.nlm.nih.gov/pubmed/24655348 “mice on high-fat diet with rapamycin given intermittently: either weekly (once a week) or alternating bi-weekly (three injections every other week). While only marginally reducing obesity, intermittent administration of rapamycin significantly extended lifespan. Significance was achieved for weekly treated group and for the three rapamycin-received groups combined. In weekly treatment group, 100% mice were alive by the age of 2 years, whereas 60% of mice died in untreated group by this age”, also, “Alternating bi-weekly treatments seem to be less effective than weekly treatment” Weekly treatment at mice brings up the question of what is the human equivalent of mouse time intervals? Weekly would be about 125-150 doses per mouse lifespan, so at a human that might be near once every 6 months for a 2018 AD human lifespan.

Enteric pill oral availability: one study of mice: “enteric rapamycin was given to male and female C57BL/6J mice starting at 4 months of age and continued throughout life.” …also, “

Drugs that might up rapamycin potency: “Sirolimus [rapamycin] is metabolized by the CYP3A4 enzyme and is a substrate of the P-glycoprotein (P-gp) efflux pump; hence, inhibitors of either protein may increase sirolimus concentrations in blood plasma, whereas inducers of CYP3A4 and P-gp may decrease sirolimus concentrations in blood plasma.[4]”

As a longevity drug and beneficial slimness drug rapamycin could have many longevity and slimness active molecular variants. Screening libraries of these variants could find better longevity and slimness chemicals, possibly without immunoeffects. It is possible molecular variants that are lipophilic concentrate at tissues more and pass through membranes more easily. hydrophilic versions could also be tested as to their effect. At Wikipedia this bacterially produced chemical has lots and lots of =O groups, perhaps replacing these o with sulfur would do something, or making some of them OH would increase hydrophilicity.

Also, a version with modified lipophilicity or hydrophilicity could beneficially effect, and minimize the noticeable variation at oral absorption at the GI tract, “The absorption of sirolimus (rapamycin) into the blood stream from the intestine varies widely between patients, with some patients having up to eight times more exposure than others for the same dose. Drug levels are, therefore, taken to make sure patients get the right dose for their condition”

A variety of rapamycin papers mention dosages, one says .45 mg/kg: “Previously we tested 1.5 mg/kg of rapamycin given subcutaneously 6 times per two weeks followed by a two-week break (1.5 × 6/bi-weekly schedule: total of 6 injections during a 4-week period). This intermittent treatment prolonged lifespan and delayed cancer in cancer-prone female FVB/N HER-2/neu mice. Here, the dose was decreased from 1.5 mg/kg to 0.45 mg/kg per injection”, also, “We conclude that total doses of rapamycin that are an order of magnitude lower than standard total doses can detectably extend life span in cancer-prone mice.” https://www.ncbi.nlm.nih.gov/pubmed/24556924

One study uses enteric coated oral rapamycin.

Another says, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038246/ [mice were] “fed on food-containing encapsulated rapamycin or empty capsules (eudragit = control)”, also, “Microencapsulated rapamycin or empty microcapsules (control) were incorporated into Purina 5LG6 diet. The rapamycin diet was prepared at 14 ppm” that paper references another paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/ which says, “Rapamycin (from LC Labs, Woburn, MA) was microencapsulated by Southwest Research Institute (San Antonio, TX), using a spinning disk atomization coating process with the enteric coating material Eudragit S100 (Röhm Pharma, Germany). This coating increased the fraction of rapamycin that survived the food preparation process by 3- to 4-fold, and protected the agent from digestion in the stomach16. Encapsulated rapamycin was then incorporated into 5LG6 mouse chow”

Noting that rapamycin is bacterially produced, some improved variation on its structure could come from either engineering the bacteria or mutating it to produce numerous screenable variants on rapamycin. On finding a more beneficial molecule that is a rapamycin variant that is produced at the engineered or mutant bacteria those genes could then be made part of a probiotic, causing beneficial levels of a rapamycin-like longevity slimness chemical to be continuously delivered at the GI tract.

Bacteria produce rapamycin. It is possible that growing these bacteria in a medium that is loaded with prechemicals, causes the prechemicals to become a part of new molecules that are a lot like rapamycin but different in structure an even elemental composition.

Perhaps chemical parts sized just 1/4 or 1/2 of the full rapamycin molecule could be placed in the bacterial culture medium to see if there was any effect on their incorporation into the rapamycin or rapamycin-like molecule. These prechemicals loaded into the growth medium could have many different chemical variations like sulfur instead of =O, or OH instead of =O, or out of plane molecule shapes. It is possible growing the bacteria in deuterated water could cause the AMU (mass) of the deuterated rapamycin and rapamycin like chemicals to be much higher, that could increase residence time at the cytoplasm or have gradual slope long curve pharmacological effects.

It seems unlikely but it is possible rapamycin with a localization molecule linked to it could concentrate at the joints, possibly slowing arthritis, or if the body has repair systems there this possibly permits repair that occurs faster than degradation, causing remission.

It is possible I will find the reference that says rodents live 60% longer after (what I remember as) a single occurence of multimonth treatment with rapamycin.

Some drug versions of rapamycin might be immunoneutral or even immunobeneficial, “In contrast to the immunosuppressive effects found in long-term high dosing, a study combining low-dose Everolimus (a rapamycin analog) and Dactolisib [another mTOR drug] for a single 6 week course followed by influenza vaccination in healthy elderly patients (>65 years of age) found that this combination significantly reduced the number of infections reported by participants relative to placebo (from 2.41 to 1.49 infections per person per year), increased the serological response by more than 20%, did not produce any excess events of hyperglycemia or hypercholesteremia (associated with mTORC2 inhibition) and was generally well tolerated.”

“enteric rapamycin was given to male and female C57BL/6J mice starting at 4 months of age and continued throughout life.”

“topical formulation of rapamycin” is mentioned at wikipedia. Reducing the aging of tissue, and with topical use, which is nonsytemic dosage, rapamycin could be a beauty drug as well.

Longevity blood pressure drugs, ACE inhibitors: At the graph the mice with the modified (reduced) angiotensin gene lived about 29 weeks untreated, 36 week as treated at oldest age. https://www.ncbi.nlm.nih.gov/pubmed/19197138 the modified mice live more than 25% longer; Lisinopril reduces this system also. “acting through Ang II type 1 receptors (AT1 and AT2). Here, we show that targeted disruption of the Agtr1a gene that encodes AT1A results in marked prolongation of life span in mice.”; Also, in humans a variation on the angiotensin gene is more frequently found in supercentenariarians and could be a beneficial longevity gene for genetically engineering humans to live longer and have greater healthspan.

A polyphenolic drug that, approximately speaking ups the maximum lifespan of the 90th percentile of longevity mice 12.4% , “Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR mice. Administration of BP-C3 with drinking water (0.005%) did not exert any toxic effect (did not have effect on general condition of animals, weight dynamics and consumption of food), postponed age-related switch-off of estrous function, caused slight reduction of body temperature. An increased survival was observed in mice treated with BP-C3 (p=0.00164, log rank test). BP-C3 increased mean lifespan - by 8.4%, lifespan of the last 10% of animals - by 12.4%, and life span of tumor-free mice - by 11.6%. A tendency in ability of BP-C3 to inhibit development of spontaneous tumors in mice was detected, though it did not reach the level of statistical significance (p=0.166, log rank test). The number of malignant mammary tumors was 1.5 times less and total number of tumors of various localizations was 1.6 times less in BP-C3 treated animals. Multiple tumors were registered in 8% of mice in the сontrol group and no cases - in BP-C3 treated group. Thus, BP-C3 demonstrated some anti-carcinogenic and a pronounced geroprotective activity.” Things that increase maximum longevity are beneficial

Senolytic longevity technology: Senolytic Cocktail Dasatinib+Quercetin has some published material; dasatinib is available online, I think it was near $250, for how much I do not remember. Another senolytic mentioned at a paper is navitoclax, “senolytic drug, navitoclax, eliminates senescent cardiomyocytes and attenuates profibrotic protein expression in aged mice. Importantly, clearance of senescent cells improved myocardial remodelling and diastolic function as well as overall survival following MI.”.

A notably affordable senolytic might be antibiotics described at https://www.ncbi.nlm.nih.gov/pubmed/30428454 “we see that Azithromycin preferentially targets senescent cells, removing approximately 97% of them with great efficiency. This represents a near 25-fold reduction in senescent cells.” A hint at dosage, “However, the effects of Azithromycin on mitochondrial oxygen consumption rates (OCR) were bi-phasic, showing inhibitory activity at 50 μM and stimulatory activity at 100 μM These autophagic/metabolic changes induced by Azithromycin could mechanistically explain its senolytic activity.”; then the paper says, “Roxithromycin and Azithromycin selectively eliminated large numbers of senescent cells at 100 µM”.

Another senolytic, fisetin, increases median and maximum lifespan of mice near 10%, with noticeably lower mortality at all ages.

Azithromycin works on more than one kind of body tissue, “Remarkably, Azithromycin also increased the viability of normal BJ skin fibroblasts, by > 25%. As such, Azithromycin shows comparable selectively and senolytic activity in human fibroblasts derived from two different anatomic sites (lung tissue and skin).”

Azithromycin is on ebay as bird pills, alibaba might have it.

Another antibiotic quantified as a senolytic is Roxithromycin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286845/ with 69% of senescent cytes killed as compared with azithromycin’s 43.99% at 100 µM Note though that, “Roxithromycin, at the same concentration, more effectively killed senescent MCR-5 fibroblasts (~70%), but also had a small effect on the viability of normal MRC-5 fibroblasts (Figure 6).

Duration of senolytic antibiotic treatment, “they were exposed to Azithromycin for another 5 days”, also, “it eliminated ~50% of senescent cells without affecting control cells after 5 days, at a concentration of 100 µM. However, Azithromycin had no effect at 50 µM. These experiments were repeated at least 3 times independently, with very similar results” Besides the “5 days” thing, there is a graph (figure 11) at the paper PMC6286845 where almost all of the senolytic effect of azithromycin occurs during the first 20 hours. At what might be described as a graph of cyte health, that area of the azithromycin treatment cyte health is greater than that of the controls at 100 hours of dose (but below it before then) with the “cyte health” of azithromycin treated cytes meeting the peak-high ever control cyte health at 140 hours.

Grams of azithromycin to be senolytic at a 70 kg human:100 um is .1 mmol, so that times 748.98 AMU azithromycin mass is 1/10,000 (100 umol) of 748.88 or .07488 grams per mole. Then, since I am uninformed, and am basing the molarity of a person on molar mass of water, multiply that with 388.88 moles of water at a 70 kg person to get 29.126 grams of azithromycin. Then wikipedia says oral bioavailability of azithromycin is 38% which produces a senolytic dose of 76.648 grams of azithromycin. Perhaps there is an LD 50 published for azithromycin that is notably higher than this.

Also, the enzymes that metabolize azithromycin will likely be used up immediately, causing a higher dose that lingers longer. It is possible that there is another chemical a person could take to reduce azithromycin metabolism even further, thus causing something like steady high curve at all 20 hours of activity (like the graph) to be senolytic.

Another use for azithromycin: I perceive I read that autophagy causes cytes to remodel and then be younger-cyte form much more. Pubmed says, “Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms”. The azithomycin as senolytic paper says the opposite, that autophagy causes senescence. It is possible I if read more I will be able to tell what the research supports.

Considering the possible benefits of autophagy: so even if the senolytic dose can be accomplished in 5 days, or as the graph suggests, possibly 20 hours, Could there also be a different lifetime longevity wellness healthspan benefit from taking azithromycin, as an autophagy (3 times) multiplier daily? Does it mess with the GI tract bacteria?

A project-oriented person would culture the 90% longer lifespan longevity probiotic LKM512 with azithromycin, then multiply that successful new culture, as an effort at making a version of LKM512 that could persist even when the person took azithromycin every day.

The paper, PMC6286845, says, “Azithromycin is a powerful inducer of the autophagic phenotype. Autophagy was quantitatively measured by detection of autophagic LC3 proteins, using the Muse Autophagy LC3-antibody based kit. Note that Azithromycin treatment resulted in a > 3-fold elevation in autophagy in MRC-5 cells.”

So just doing the usual, lipophilic and hydrophilic versions of roxithromycin and azithromycin, new senolytic antibiotics could be made and compared as to their youthification, longevity, and disease reduction and or treatment benefits.

Approximately the concept as I perceive it is if you kill off all your senescent cytes with a chemotherapeutic agent, it then it takes quite a while for any new, cytotoxin secreting, senescent cytes to build up to the previous amount, so then you take the senolytic again after an interval. That completely removes senescent cytes that are secreting material, senescence-associated secretory phenotypes that harms other cytes near them.

My perception is that senolytics kill old cytes, keeping them from secreting antifunctional things onto other cytes.

Is it possible to find another thing that kills senscent cytes? It is possible that photons and a harmless cytostain(possibly like the continuously living organism stains at carolina biological supply)that concentrate at live senescent cytes could do optical senolytics. At the surface and perhaps a few cm deep, or more with cofocalized lasers, senescent cytes could be live tissue colored and then zapped out of existence. This might work with just colorizing organelles. Perhaps colorizing mitochondria at senescent cytes is easier than getting the whole cyte or the bigger cytomembrane to have live-organism color. Zapping the color light absorbing mitochondria or other organelles at a custom absorption frequency only at colorized senescent cytes would also be senolytic

Photoactivated senolytics could be a beauty youthification technology, and could possibly be used both after and before aging to block senescent cyte-communicated effects on the well dermatocytes. It is possible to imagine a 30 year old getting her skin aging velocity to be 1/2-1/10th the untreated velocity if she uses photonic senolytics at 30. Kind of nice to keep looking 30 when you are 70. As a mild thing, it is possible methylene blue, a longevity and nootropic chemical could be the light absorber, so having a dose of methylene blue at the person would have slight side benefits.

Photosenolytics with a living organism stain might benefit senolytic maintence of a healthy retina, causing younger vision longer.

Noting flashlight fingers, photosenolytics with a living organism stain might reach through to the joints removing senescent cytes and then be quantitatively measured as to whether this prevents or treats arthritis and reduces discomfort.

Photosenolytics, possibly with tissue depth from the reach of cofocalized lasers could even benefit the spine and back. Online a paper says, “We found a 40% higher level of senescent cells in degenerate compared to non-mildly-degenerate discs from unrelated individuals” Noting this is an in-vitro study so human oral doses are not covered, the paper summary seems to suggest that senolytics, [it mentions Curcumin and o-Vanillin] make disc cytes functionally produce what I think might be called collagen matrix; an improved composition effect. The photosenolytics could, like curcurmin or o-vanillin, kill senescent intervertebral disc (IVD) cells allowing the tissue to regenerate from the remaining younger cytotypes and without the intracyte harmful chemicals. “Both drugs cleared senescent cells, and treatment increased the number of proliferating as well as apoptotic cells in cultures from degenerate IVDs. The expression of SASP [senescence-associated secretory phenotype] factors was decreased, and matrix synthesis increased following treatment.”

It is possible other frequencies of electromagnetic radiation besides photons could cull senescent cytes using the senolytic approach; those eentsy gold nanoantennas might be tunable across a wide range of EM frequencies that they can absorb; the antennas could also be linked to antibodies to concentrate the gold nanoantennas at some particular tissue or cytosurface to receive a senolytic treatment.

Is there anything senescent cytes, across many different tissues, have as a cytosurface membrane difference from well cytes? If there is a shared senescent cyte surface that is there between tissue types, then a senolytic linked to an antibody to that surface protein could be a senolytic longevity drug functional at many tissues.

Using a shared senescent cyto surface at many tissues: could x-rays be used to activate senolytic drugs at full body depth. Something like a metalloprotein (imaginably bismuth metalloprotein), linked to an antibody that then goes on to attach to the shared surface feature of senescent cytes, would absorb more radiation than the rest of the body, causing the molecule to be electrically charged and like a free radical that is cytotoxic right at, and only at, the senescent cyte. This removes senescent cytes at any body location, but differs from a bodywide dose of a chemotherapeutic senolytic drug.

Quantum dots could be a senolytic, electromagnetic frequency tuned technology as well. The quantum dots could be linked to antibodies to senescent cyte surface(possibly shared at multiple tissues) and that 2 part thing linked to a cytokilling chemical; the quantum dots are energized with a particular frequency of light. So there is cofocalized and light directed senolytic treatment as well as photoenergized senolytic treatment. It is possible this kind of energetics would also work with fluorophores; sometimes antibody conjugated, these fluorophores concentrate at tissue or cytotype and the fluorescence shows people where it is; linking the fluorophore, which could be stimulated at a particularly frequency of light, to a senolytic cyte-killing chemical could create a photo-simulatable senolytic.

At senolytics it is possible to imagine that along with wiping out senescent cytes, it is beneficial to have the phenotypically young cytes proliferate benignly. One online paper mentions dexamethasone, “Anti-inflammatory treatment with dexamethasone induced regrowth of senescent cells and inhibited the SASP [senescence-associated secretory phenotype]”. So it reads like with the SASP reduction version, that normal youthful phenotype cytes regrew. That there is a chemical (dexamethasone) that apparently increases well tissue mass suggest that other chemicals could be produced like the often mentioned hydrophobic, hydrophilic, halogenated, chemically linked to a protein that has a transport channel, phenyl group, or S or N moiety variations on dexamethasone.

Could senolytics, or an analogous idea: damagedolytics, reduce scarring? It is possible that it is not just scar tissue that forms scars but intracyte SASP-like effects from damaged-phenotype cytes could be linked to scarring. Damagedolytic treatment drug eligible tissues and cytes might not be technically senescent but they, like a senescent cyte, might be far from a physiological biochemical equilibrium. If you look at they cytes next to a surgical incision, cut or scrape there might be a normal distribution of messed-upness. Some cytes will barely be biochemically perturbed at all, other cytes at an incision, cut or scrape might be emitting a lot of SASPlike chemical effects. A damageolytic would kill off just the injured cytes at a tissue that were actually causing further injury from SASPlike effects. The damaged cyte’s “harmful SASPlike goop” could be precluded from spreading with a previously researched senolytic compound to reduce scarring.

So along with the longevity applications it is possible a benign after senolytic treatment cytoproliferator, possibly dexamethasone, could be a beauty technology that accompanies the senolytic technologies. Beauty increasing senolytics would actually also regrow youthful skin from the continues-to-exist base young phenotype cytes that were responding to a benign cytoproliferative chemical.

New to me is hydroxybutryate causing cyto quiescence; described at a paper as “senopreventative”, “The ketone body -hydroxybutyrate (-HB) prevents senescence by inducing quiescence in endothelial cells. -HB activates hnRNP A1, which then binds and stabilizes Oct4 mRNA. In turn, expression of Oct4 in endothelial cells induces quiescence, which protects cells from DNA-damage-induced and replicative senescence” So the quiescence concept at the paper https://www.ncbi.nlm.nih.gov/pubmed/30259779 might be something like: telomeres stay the same length, and the hayflick effect is at a steady state middle nonchanging number”

Some senescence producing cytochemicals could be at the circulation as well as cyte-cyte neighbors, possibly making a longevity youthfullness, healthspan increasing immunization possible. One paper says, “SASP results in the secretion of a wide array of inflammatory cytokines, such as IL-1-beta and IL-6, allowing senescent cells to “contagiously” spread the senescence phenotype from one cell type to another, systemically throughout the body, via chronic inflammation” Then another paper says, “MiR-570 is also involved in reduction of sirtuin-1 and cellular senescence” also, “[senescence biochemicals] locally within the lung but outside the lung through the circulation; this may account for comorbidities of COPD and other lung diseases. Understanding the mechanisms of cellular senescence may result in new treatments for chronic lung disease, either by inhibiting PI3K-mTOR signaling, by inhibiting specific miRNAs or by deletion of senescent cells with senolytic therapies” Apparently there are small RNAs like MiR-570 that are senescence-spreading that can circulate at the body. There are also said to be circulating proteins like “IL-1-beta and IL-6” Immunizing against these protein objects could reduce aging.

Cyproterone acetate could have a enunch like longevity effect.

Mid april 2019

Laser tractor beams

These can move things .1 to perhaps I misremember 1 mm (2018) at liquids, so they could be used to de chaff grains and sweeprfaces that should be clean, perhaps even surfaces that are dry.

grain dryer: using arrarys of IR semiconductor lasers you could micro beam warmth just onto the grain and skip warming the chaff.

I read that that grain is dried to 15% moisture, from perhaps 25% at source grain. I think this could be a commodities social convention number rather than an engineering optimized number. Perhaps 16% or 14% provides better results. (25-15 =10) 1 percent point difference of input drying energy could represent 10% of the energy, from 25% to 16%, used in grain drying. At about $22 per quantity of grain (some online reference), and only about $2.32 spent on labor to harvest that quantity of grain, changing that social or engineering convention to 16% could free up as much money as all the labor input costs when growing grain.

I read that women and girls experieinced at puberty find the female form attentiveness increasing and sexy, even if they are not behavioral lesbians. Aside from the research that has likely already been done on eye tracking and ad effectiveness they could do pure research on the female forms allure to women and girls. This could be used to produce images that women and girls like.

.5b I perceive that men go to the doctor less during 2018; they could research if online chat bots, live chat windows, drop-in care (urgent care) increase male participation in symptom description and diagnosis 10% more. Globally that could represent hundreds of millions of men getting better health care; studies on the effectiveness of medical chat robots and applications could be divided by sex with the express purpose of heightening men’s measured as successfully treated outcomes, not just participation.

They could research what lifestyle change is the absolutely easiest and most adhered to, then not only advertise that, they could base extensions of preventative medicine around it. Let’s say it’s skipping eating the french fries at a value meal. Not only could they advertise that to reach more people (.1% improvement at 300 million people is 300k lives improved), They could call a burger sliced into 4 quarters a “pizza burger” and then urge people to toss 1/4 out.

Finding things, notably third variables, that arise from correlations, when causation seems implausible:

Better P values; expanding the p value: Also at math, deviations form expected distibutions, like a multimodal distribution instead of normal distribution, could clue the software or human in on not just the third variable’s multi-componentness of possible utility or knowledge value (among several possible values (purposes) could be the actual source causes of space or hanging); so just like the software screens a library of published numbers/data it could screen the two source implausible correlates for the structure of the data’s statistical distribution (like normal distribution compared with multimodal, or time-series where one happens all at once and the other happens gradually). Finding, or narrowing, the original two phenomena to their statistical distributions, among the possibilities being time-series, could be used to match them up with a list/library of things with similar distributions/math identities. Linear algebra equations that are similar between (ranked list/top of list producing) library items could be batched and looked at to isolate the third variable that contributes to the correlation at the two source items (hanging/space)

Speaking of time series values and statistics, could p values be improved if there were, more frequently, a part of the experiment, that had a duration-engineered component. Smething that is like p < .05 could go to p<.01 if there were a time component, just from doing the equations where two separate measures of pattern in data were used simultanously to output a new number similar to a p value. Of course, these could be any of a variety of mathematical descriptors not just time-series.

At Quora a Quoran, not me asks,

If correlation does not imply causation, what *does* it do?

Then I wrote,

This gist of this reply: It reminds me that there might be an unstudied third variable. This third variable might have even higher correlations than the initial two items, computer programs could be one way to systematically isolate the useful third variable. It is possible that making new lists of correlates with a standard screening library of like a million different things reveals things that can be tested with an experiment, or have the math results improved with more iterations of causality equations. I suggest the most mathematically supported third variable constellations be called marionettes after the thing that controls a string puppet. Finding the most mathematically supported “marionettes” creates the possibility of finding things, which if changed, will affect the original two correlated items. So, big matrices find hidden correlations, these are ranked, testable ones are pulled out by the software, and people can then see if any of the marionettes (correlation constellations) inspire fresh human insight. Screening the marionettes (correlation constellations) with rigorous math could cause actual knowledge discovery even without human insight.

Two things: space and hanging. I read at another Quoran’s answer that there is what seems a cognitively implausable correlation is that space funding causes hanging, or that hanging causes space funding. However, intuitively one can think of a few as-yet-unstudied third variables that have even higher correlation than hanging with space.

• One could be affluence of the society. More money available at the society could cause space projects to be funded while simultaneously producing a social environment like spare time or perhaps parenting fads that caused mental illness and thus hanging.

Finding third variable correlations: that brings up the possibility that a computer program could look for say 100 things from a list, each like its own new hypothesis on unresearched causes, with separate numerical effects on each of the two prime correlates.

The program would then list the hanging and space correlations of these 100 items out in order, for each of space and hanging separately, and then the top of the co-occuring to produce a shortlist that is common to both the third variable’s correlation to each of space and hanging.

A human or software program could look at the separate lists’ ranked correlations for causal plausability (or iterative passes at the math/program). So at the space/hanging thing the computer would list out the correlations of space and hanging with each item from a standard library of causes:

• geographic region correlation 1%

• Age of people most involved correlation 20%

• money surplus at society correlation 15%

• permissive/nonpermissive parenting style of the humans involved correlation 15%

• decade-hours of media/publicity spent on (spac/hanging) correlation 10%

• 95 or 95,000 other possible correlatables, called a lbrary, at a computer screenable list

So then ordering the correlatedness of items from the computer’s big library of correlatables, The computer program makes a shorter list of where both space and hanging have the highest numerical correlation to the library of possible causes, or driver items, providing a shorter list like:

• It might be that they are the same age (30%)

• It might be that money at society drives the correlation (25%)

• Media popularity could be driving both space and hanging. (15%)

This short list of items could be bundled and called the “marionette” after the + shaped thing that directs the posture of a string puppet. A marionette could be described as a constellation of possible causes as well. The computer program could then list several different possible marionettes, made up of completely new things (different than the source two data items), to explain the cognitively implausible hypothesis (hanging causes space, or space causes hanging).

Beneficially some of these different marionettes would have testable components as well as areas of historic variation. Those cause-groups (marionettes) might even have actual world or laboratory adjustable parameters that could be used in experiments. Also, there could be an all computer version: screening the marionettes (correlation constellations) with rigorous math several times could cause actual knowledge discovery even without human insight. Giving computers the ability to write and do actual experiments supports this form of knowledge discovery.

This making lists of marionettes, mentioning which contained experiment friendly adjustable variables could be an AI/computer program thing.

Continuing the idea of a screenable library of correlations:

At math, deviations from expected distibutions, like a multimodal distribution instead of normal distribution, could clue the software or human in on not just the multi-componentness that produces utility or knowledge value (among several possible values (purposes) like the actual causes of space or hanging).

Just like the software screens a library of published numbers/data it could screen the two source implausible correlates for the structure of the data’s statistical distribution (like normal distribution compared with multimodal, or time-series where one happens all at once and the other happens gradually). Finding, or narrowing, the original two phenomena to their statistical distributions or other math-shape, could then be used to match them up with a list/library of things with similar distributions/math identities. Linear algebra equations that are similar between library items could be batched and looked at to isolate the marionette/constellation/third variable that contributes to the correlation at the two source items (hanging/space)

The screenable library of third variable sources, is from 1000 or 10,000 previously published items, often at the scientific literature but would also benefit from private sector data sources as well, that have measured numbers. In fact, with a big enough computer, you could make the library or correlatables not just a million things, but be every item that has ever been measured and published.

Viewing a list of marionettes a human mind could generate new testable hypothesis. Software could also generate hypothesis, emphasizing areas where experiments were possible because of changeable, measurable parameters.

Not on the topic of the question, but fun to think about anyway: thinking time series values and statistics, could p values, basis of 20th century discernment and guidance, be improved if there were, more frequently, a part of the experiment, that had a duration-engineered component. Something that is previously like p < .05 could go to p<.01 if there were a time component, just from doing the math equations where two separate measures of pattern in data were used simultaneously.

(.5b)

Improving Child Support: Could there be such a thing as a CSO like an HMO; Child Support Organization where coverage plans and costs are defined, and possibly the mass aquisition of resources or sponsorship of value providers provides more support at the same amount of money. Note however that there are those that feel HMOs are less than optimal. Is private daycare cheaper and better when implemented by a CSO nurturing 100,000 children? CSOs could publish their outcome numbers like school grades, low neuroticism scores (big 5), and reduction of conflicts with the law, and less teen pregnancy. If these numbers are better than the median at the non CSO population then this private sector CSO would be a benefit to children and society.

at the .5B:

CSO Child Support Organization

There are HMOS, a Child Support Organization could improve measured happiness and other outcomes while finding cost efficiencies, aove measured happiness and other outcomes while finding cost efficiencies, making the child support go further.mkign the child support go further.

(0)

[vote for,

against]

Could there be such a thing as a CSO like an HMO?

A Child Support Organization (CSO) where coverage plans and costs are defined, where it is possible the mass acquisition of resources or the sponsorship of value providers provides more support at the same amount of money.

Note however that there are those that feel HMOs are less than optimal.

Is private daycare cheaper and better when implemented by a CSO nurturing 100,000 children? Measure it. CSOs could publish their outcome numbers like quantifiably measured happiness, school grades, low or reduced neuroticism scores (big 5), reduction of conflicts with the law, and less teen pregnancy. If these numbers are better than the median at the non CSO population then this private sector CSO would be a benefit to children and society.

The measurement thing matters a lot. A CSO plan that raises the group well being may not serve children with particular personalities well. There is a science-of-psychology personality test called the Big five. The CSO could look at the effect of its programs on big five clusters, like people of high conscientiousness or low conscientiousness. Children, and possibly parents, tested as low or high neuroticism (translation: anxious and messed up or calm,confident, capable) might have different outcomes than the group improvement effect. There is a remedy.

The CSO has an opportunity to create group, but perhaps not individual, plans that most benefit the child's measured personality. Perhaps the high neuroticism children benefit from secular waldorf preschool/daycare. It is possible conscientious children do better with unusually well organized but still nice, childcare. Rather than a monoculture it is easy to imagine a few hundred CSO service delivery styles.

One risk of course is that although she does not get pregnant at 16, the CSO might prompt her to get an internship at a job that has lower than average pay, forming her career and lifetime earnings.

Another upside is that the CSO has an interest in fuller, more effective collection of the actual child support money from the less-there parent. Note this all runs outside of government funding, which means the plans and offerings are more diverse.

—

beanangel, Apr 14 2019

A person on Quora writes, “When we learn things we do them habitually without thinking about it. Learning something new takes effort and energy, repeating once learnt doesn’t take nearly so much effort or energy. In that way, it’s evoluntionarily advantageous that we do things “on autopilot”.

That makes me think I could learn to do social things with the couchsurfing guests, things that benefit them, but also improve enjoyment and well being from their visits. Perhaps a board game, or a “get to know you” exercise (what is the effect of the “36 questions that get people to fall in love with you” if you only ask 3, and it’s guys, and I noting I prefer women); or group of questions, or even a “discuss it after and during” psychology quiz (Cosmo quiz entertainment) I could tell Shay Stacer I’m going to read a book on party amusments to be a better host.

I think I read at laser eye surgery, the computer can just map the shape of your eye and cornea and figure out how to change the shape so you can see. I think it is considered much more reliable than the glasses-getting optometric exam.

So theoretically an optometrist could have a child look into a machine to find out if there vision was normal. It is possible effective optometrists and opthamologists already do that. So that brings up the possibility of a technology, like at the mall, where children just look into a machine and are told if they would benefit from vision improvement. Also I read laser eye surgery works on 5 years and that there are doctors that do this. An automated machine that improves children’s vision would be beneficial.

I have written previously about creating an artificlal sweetener that causes greater longevity, among a few versions is the 4 amino acid epitalon peptide linked to sucralose, or possibly better, a sweetness peptide. So as another longevity flavoring or “Spice” could siRNA drugs or other nucleic acids be flavor optimized while retaining beneficial biological activity so that they make foods taste better just like MSG (monosodium glutamate) does? Even a poly-MSG (PSG) attached to a beneficial siRNA or peptide, possibly with an enzymatically degradeable linker that lasts through the mouth but divides the peptide from the MSG at the stomach, could work. If it goes really really well people might possibly prefer it to salt.

Longevity technology: Online it says, “The half life of mRNA is very short.” it is possible making it last longer, perhaps by downregulating enzymes or genetically engineering the organism could have a drug effect. One possibility is younger phenotype (youthfulness) as I may have read that cytes with fewer mitochondria make less ATP, and less ATP makes production of some proteins take longer or even be skipped. If the mRNA persisted longer, perhaps more of the youthful distribution of proteins would be produced, because the “make protein, and make this particular protein” messages would persist even with fewer mitochondria and less available ATP. Modifying mRNA duration gives the mRNA more time for the rest of the cyte to let however much or little of the ATP that there is to meet up (diffuese) with protein production things like ribosomes.

Either way, longer or shorter mRNA, it could be a drug: engineering the organism or increasing the amount of mRNA disassembly enzymes (mathish/computerish loop proliferators or decreasers) could act like less than usual energy at the organism. Could even faster removed mRNA imitate caloric restriction to increase longevity as simply less mRNA-specified proteins of all types would be made?

Could a drug that heightens mRNA removal be an anticancer drug because the oncocytes genetic transcription and protein production could use some protein more than another. you could do a localization molecule or an injection with a “less of all mRNA” drug.

Longevity wellness technology, anticancer drug: tRNA drugs: mRNA drugs remind me of other things that could have a systemic phenotype-wide effect, possibly a little like the way histone methylators or acetylators affect the entire organism at once. Drugs or genetics that modify the amount of tRNA, transfer RNA, could be another all-body phenotype drug. More tNRA available to transport amino acids could cause proteins and tissues to be made more rapidly, speeding healing, and possibly causing the nucleic acid-mediated part of memory that has to do with protein work better. So more tRNA could produce faster healing and better memory.

Less tRNA could though be calorie restriction mimetic. So a thoughful researcher might use a completely different calorie restriction mimetic drug, like an mTOR drug, while preferring to increase tRNA to improve cognition and healing.

Custom tRNA amounts for each amino acid as beneficial drugs: Also, I may have previously written or recorded an idea/technology where you increase or decrease specific tRNAs, so some amino acids availability isfavored over others, which then affects proteins everywhere, cytes, and tissue production. A drug that causes 50% less methionine tRNA could be a drug that slows the growth of cancer if the cancer uses lots methionine to reproduce.

There is kind of a math thing, where if you know a tissue or cytostructure you want to make more of than some other part, then you can make lots of tRNAs that favor the most frequently occuring amino acids at that protein. So while an average protein might have average number of arginines in it, and an awesome protein you would like there to be more of is arginine rich, then making lots of tRNA for arginine could cause more of the awesome preferred protein to be made, as the ribosomes would fill up faster and process more copy creations. So the math thing is finding and listing all the most beneficial proteins, then finding other groups within that group of beneficial proteins that have a different proportionality of some amino acid (like all the longevity proteins that happen to be rich in proline), then increasing the amount of proline tRNAs which causes proprtionately more of the awesome longevity proteins to be made. The math thing is where you look at protein components’ amino acids, compare the more tRNA or fewer tRNA effect on projected amount of the protein produced.

Methionine reduction at diet is published as causing greater longevity, they could see if mice with fewer methionine tRNAs live longer while also measuring their social and cognitive abilities to make sure it is actually without side effects and completely beneficial.

There are entire bulk-phenotype effects of amino acid availability published. Just supplementing the pregnant person with arginine alone makes babies weigh more, which is predictive of well personness.

I read that there are many components to producing proteins, cytes, and tissues. As drugs, finding rate limiting things at protein/tissue production is really the thing to research for new beneficial drugs. Perhaps it is the number of ribosomes that matters more (rate limits) than the amount of tRNA, although customizing the amount of each amino acids tRNA could guide what proteins are produced. I perceive that number of mitochondria has an effect. So amount of ATP could be rate limiting. Once rate-limiting things are described, then you can just say things like “a drug that increases the number of ribosomes”, or “bigger golgi apparatus if post-translational processing is the rate limiter”

Could botox on eyebrows alone improve impression of mildness or friendliness, sometimes to make a face look intense all they have to do is draw the eybrows differently, so relaxed eyebrows might send fewer arched-eyebrow singnals all day.

Better grain drying technology:

I read that at the US grain dryers cause grain to go from something like 25% water to 15%. One online source says grain uses 39 cents of warming energy a bushel to dry along with 7 cents of electricity to make 46 cents a bushel to dry grain.. Early april, 2019 at the US, a bushel of corn goes for $3.63, so grain drying is less than 14% of the value of corn during 2019 AD.

Previously described is a thought that how changing the engineering standard of what is “decay-resistant dry grain” to 16%, noting that the previous round number, 15% might have been an arbitrary standard, might be possible, which with one percentage point difference might reduce the amount of money spent to dry grain to decrease 10%. Noting there are other countries, likely with variations on the amount of technology adoption of newer more effective grain dryers, it is possible that some places like Russia or China have different grain drying efficiency than the US, or that grain drying in China is expensive because of imported methane/propane costs compared with the US. Based on something I read, it is possibly less efficient in Russia.

I thought of a grain dryer technology, but I think it is not actually of utility, because I perceive I read that warming a big pile of grain, then letting is cool is 20% more effective than customized warming air blends. So, because I think it might not really work I am putting it in brackets [[So, a technology that makes drying grain more energy efficient with less contingency on the optimality or newness of the grain drying machine is to have little wireless nuggets or clamp on wireless sensors that broadcast their airflow and temperature, and possibly moisture content These rapidly retrofit any grain dryer, even old or foreign ones. psychrometric reporter quick-install clamp ons make it possibly to dynamically adjust even older or less efficient grain drying equipment, possibly that at the developing world, to optimize airflow and warmth to dry the grain. A computer uses the sensors to tell when the grain is optimally dry. The psychrometric retrofit objects, note moisture % content, temperature, possibly airflow velocity, and possibly the motion of the grain around them (The software the clamp-on talk to does the air volume/temperature controlling) Optimized this could retrofit at the majority of existing, old and foreign grain dryers, even old ones or ones at the developing world.

Noting that at a described online US grain dryer 25,000 bushels get dried in 10 hours, it is possible that clamp-on wireless networked sensors would be more functional, findable, and durable than something like a reporter pill that gets tossed in withthe grain.

One of the big benefits of wireless with app-style software is that there is an absence of need for skilled labor to wire up sensors or the knowledge to install and use software at retrofitting an existing dryer; that makes it cheaper and removes barriers to efficiency at the developing world. The software could be snazzy. Clamp some sensors around the grain dryer, and your phone tells you the rest. Optionally at non-developing world grain dryers that have existing computer control, the phone software tells the dryer things and controls how warm and how much air. Words like adaptive control, neural network, and big data could benefit any preexisting grain dryer; these capabilities are likely already a part of new developed world grain dryers.

Online it says, “His recommendation is to closely monitor your dryer when you change fields or when you’ve changed varieties to make sure the dryer is running where you think it should be”, so it sounds like a camera sensor that could tell one variety or field batch from another at the software could assist the dryer in optimizing and customizing throughput and possibly warmth and air velocity at each software detected batch for greatest fiscal value and quality optima. A plurality of cheap clamp-on sensors could provide higher quality data. Online it says, “Moisture sensors are temperamental. It only takes one little stock of grain hanging up in the wrong place to throw their values off,” says Hartwig. “You should pull samples two to three times a day.” So 3-7 wireless networked sensors at the clamp-ons could be software processed to provide more reliable data for automatic use.

I do not know which wireless technology is optimal for the data reporting wifi clamp-ons. clamp-on to clamp-on radio networking with the edge clamp-ons reporting to computer software is one possibility. Although I really doubt they would be thermocouple powered perhaps it is a possibility. Alternatively edible battery chemistry could be used.

There are some really really simple images at my notebook, but I think grain drying efficiency might go up if the exit exhaust temperature is the same as ambient outdoor air temperature. So if it is completely cool air coming out, but ambient to avoid condensation or “cooling from blowing wind effect” then the aerodynamics and travel path of the air did its best at warming the grain to evaporate water; this might not be accurate though, as psychrometry might have a thing where amount of water “dissolvable” in air varies with temperature. So if, If ambient temperature water-laden air is optimal or near optimal as exhaust from a grain dryer then you could make a thing, where warm air blows upward at a column of grain above it, until it is so fully utilized it is outdoor ambient temperature. Visualize a stack of horizontal shoeboxes. At a grain-friendly starting drying air temperature the travel path to get to cool might not be that far. Perhaps it is sort of therefore one shoebox tall to go from dryer air to moist ambient temperature air. To have high numbers of bushels dried per hour you stack the shoeboxes. So then you have a ladder of pipes serving a stack of shoeboxes, with each shoebox volume of grain being de-moisturized at the psychrometric graph optimized temperature. It is possible that existing grain dryers might or might not have used much warmer air, forced through a much deeper height of screens of grain, which was not psychrometrically optimized. Then again they might be awesome! At some shoebox height and dry air temperature the psychrometric graph curve finds its most energy optimal spot.]]

However, online it says something completely different than the psychrometric optimization of air temperature shoebox thing: about thrifty grain drying: They ignore airflow; ““One thing that’s been around for a long time but is still cost effective is running a portable dryer in the all-heat mode,” says Woodruff.

In all-heat mode, you heat the grain in the dryer and cool it in the bin. “The advantage is you can come out of the dryer at a higher moisture content, and then you lose one, two, or three points of moisture in the cooling process,” explains Kerry Hartwig, Sukup Manufacturing Co. “Drying those last points takes the most energy.”

That can save you 20% to 30% of your operating costs, says Woodruff. Running in all-heat mode also increases your efficiency, because grain flows through the dryer more quickly. Plus, you end up with better quality grain, because cooling grain rapidly can increase stress cracks on corn kernels.”

Another likely nonfunctional bracketed thing [[When I was in California I noticed that sitting on the ground was warm, and that sitting up high was cool. It is possible that the air intake of a grain dryer could be like a tall stack and pull air from variously the least humid air which might be farther up, or if preferred warmest air, at the surface of a slab on the ground. So a big tube gets warmer air, or less humid air, from a different elevation.]]

Tissue localization technologies, anticancer drugs, longevity drugs:

DNA zip codes make things concentrate at particular areas of the nucleus. A chemical attached to or coated with “DNA zip code” might concentrate at particular locations at the nucleus, like the periphery, that the zip code DNA codes for. If you put a DNA zip code on a chemotherapy molecule, possibly even an eentsy Au or Pt molecule, plus possibly an optional nucleus transport facilitating (NTF) little chemical or even something as big as an NTF protein, does that make the Au/Pt chemotherapy concentrate at just the right part of the nucleus to disrupt cytodivision to cease tumor growth. Possibly combining these things, with the microarea concentration at the nucleus, makes it so there can be a lower systemic dose of the bad for cytes chemicals, making chemotherapy less unpleasant and harmful to the well parts of the body.

I think I may have heard about using virus’ to infect cancer cytes as a cancer treatment. Of herpes and not cancer online it says, “The capsid then traffics to the nucleus where it binds to a nuclear pore and injects its DNA through the pore into the nucleoplasm.” so if they modify a virus to make stuff with DNA zip codes on it does it get preferential treatment at the nucleus so more of the virus, and its cytoterminating effect is produced. That would make it easier for the virus to wipe out the oncocyte.

GSK: There might be a drug localization effect from “actin webs”. At the cytoplasm I perceive there are a bunch of webs of actin spanning various areas. Wikipedia mentions “microfilaments”. If you think of filtering BBs or snowballs through a piece of string art it is possible to think the BBs might diffuse evenly while the snowballs might cluster at certain areas of the cytoplasm/string art. So making proteins that are the right size to percolate and sort through the actin or other cyto-microfilament webs to concentrate at particular areas or even at organelles could be a cytoplasm localization technology. It is possible these string-art sorted proteins could have peptide drugs or protein drugs as part of their structure, possibly at branches. It is also possible that protein degrading enzymes that might naturally exist at the cytoplasm, (something-ase) could be used to/spontaneously dissolve the area between the drug peptide-branch and the transporter-friendly protein while it is at the preferred cytoplasmic area and/or organelle to release the drug peptide or protein. The possibility of using protein transport channels at the cytomembrane to transport the actin web sorted blobs is there. Possibly that suggests that peptide drugs as branches from an already transporter transported protein, could function as organelle/cytoregion localized drugs.

Longevity technology, favoring the repoduction of mitochondria with youthful and programming mitochondria. Actin web localization of peptide drug delivering proteins as a technology could possibly direct peptide drugs directly to mitochondria, improving energy use, ATP, and even possibly being a senolytic removing senescent mitochondria to cause the younger form type mitochondria to be the kind that reproduce. Optimally this combination of new mitogenesis at mitochondria stimulated with drugs, as well as micorfilament/actin web localization of mitochondria specific senolytics, would populate the cytes and cytoplasm of an old organism with young mitochondria at quantities that are usual at the young phenotype. My perception is that youthful physiotype and youthful quantity of mitochondria cause the energetics of protein production to make the full complement of young phenotypes’ proteins at their young phenotype protein production velocities and amounts. The youthful phenotype of the mitochondria and amount of mitochondria modifies, improves and gets around the only partial coverage or output at the production of functional proteins at cytes with fewer or senescent mitochondria. This could be a healthspan increasing drug.

Aside: so does post-translational processing like the golgi apparatus differ between old and young phenotype? Could there be cytoplasm localized drugs, or DNA-zipcoded nucleus transport motioninizing that bring peptide or protein drugs to the golgi apparatus to improve it?

Improving human genetics. There are some areas of genes or genes that are described as highly conserved, that is they change very little between widely differing organisms. like actin genes are 80% the same between people and yeast. Improvements to highly conserved genes may be possible and could beneficially effect the entire organism.

Similarly cytoplasmic localization could work with things like mTOR drugs or rapamycin and what I read are called rapalogs, to create tiny doses with beneficial longevity and healthspan effects. It is possible that cytoplasmic localization utilizing tiny doses could make implants or once a decade longevity drug injections possible.

As an anti-cancer drug, cytoplasmic localization, possibly with actin-glomming aptamers or antibodies/mini-antibodies, or actin web protein blob sortation, with peptide drug branches on the protein, could target lysosomes causing apoptosis at oncocytes. If there is any findable variation, particularly big findable variation, at cytomembrane protein transport between well cytes and oncocytes, then at those differently tansported proteins that oncocytes tranport more this could be a concentration and localization basis of lysosome active peptide drugs that branch from the transported protein. Well cytes would get lots less of the lysosome activator drugs. That localizes the chemotherapy to the cancer cytes and tissues making the drug less harmful and more anti-cancer to the well parts of the body.

So as an aptamer or antibody glomming thing, if there is an aptamer to actin at the cytoplasm, or even an aptamer or antibody-like glommer that gloms what wikipedia calls microfilaments, along with the simpler version that gloms to actin, does this provide durable attachment of a protein, possibly with peptide branches that are the actual drug, at the cytoplasm or particularly at localized areas or organelles. That keeps the peptide drug source from diffusing out or being exported from the cyte. Also, if it is possible to move aptamers, antibodies or other glomming molecules through a protein transport channel, the shape and span of the glomming might be able to concentrate or localize at perticular densities or shapes of actin webs that differe around different organelles. Say there’s a narrow dense spot, or a light fluffy wide spot, having wide-spanning or narrow spanning glommers than span multiple actin filaments could do even more localization as compared with just glomming actin.

I read about a little molecule that when attached to other things causes them to be preferentially transported into the nucleus of the cyte. Are nuclei normal and typical during cancer, or are they weird? If they are weird, then a nucleus transport little molecule linked to another little molecule active drug could be an anticancer drug. Like if an oncocyte nucleus does something 10 times as much (like do cytodivision stuff), then reducing the frequency of that 10 times thing could slow cancer growth. like colchicine linked to the nucleus transporter chemical would bring eentsy doses of a mitotic poison right to the nucleus. Normal cytes would not be dividing as much so the drug might be like a nucleus localized chemotherapy at oncocytes.

I am dubious about this cytodivision timing idea: If you could get the nucleus concentrating mitotic poison to last just a few hours, or the possibly (possibly not) faster interval of oncocyte multiplication, you might even be able to get an effect where the mitotic poison skips normal cyctes that take higher hours to divide. Or it would rinse out/dissolve faster than it could effect normal cytes. Screen libraries of things like mitotic poisons or centromere disruptors to find some that are brief buf effective, possibly sparing normal cyctes, then use the nucleus transport little molecule to get the full effect at a much littler systemic dose of the chemotherapeutic drug.

Another oncocyte timer drug could be if they found out if oncocytes have any upregulation of protein disintegrating enzymes (thing-ases), possibly for specific proteins. If they do, then those proteins are something that oncocytes would be much better at disintegrating, and if an eentsy molecule poison, possibly an Au/Pt thing is attached to the degradation heightened protein then the liberated chemotherapeutic drug would concentrate as an active poison at oncocytes particularly, while being dissasembled much more gradually at normal cytes. They might get a lower sustained dose, which could be less harmful to normal cytes. Then, if the protein-poison combo that gets activated much more rapidly at oncocytes has a half life of like 24 hours anyway, where when it naturally degrades it breaks the poison part of the molecule apart so then the remains of the molecule is harmless, then even the protein-poison that has soaked into normal cytes is harmlessized possibly before normally occuring cytodivision.

The little molecule that I read about that causes nucleus transport might be linked to something that only disrupts the transcription and translation of DNA locally at the weird anomolous oncocyte nuclei. Possibly the heightened frequency at which oncocytes divide could make them slightly “weird nucleus” or have a particular nucleus activity level, so are easier to localize and target. One possibility for “weird nucleus” is that centromeres might be more likely to be there, or any of the other structures of PMAT (-interphase).

Ribosomal anti-cancer drug: Ribosomes make protein, noting it is possible that cancer cytes and tumors might make more protein more rapidly than normal cytes. It is remotely possible that something that gradualizes the velocity of ribosomes at producing protein could reduce tumor growth velocity. Possibly a site injection or an antibody linked to the possibly eentsy molecule ribosome gradualizer could concentrate the ribosome gradualizer at oncotissues.

It could be a new kind of drugs if there are any antibodies or glomming antibody fragments/parts that can somehow be transported across the external cytomembrane and even the nuclear membrane. My perception is that antibodies, even just the glomming part of antibodies I think are called aptamers, are sizeable proteins. I have heard of protein transport channels but do not have any idea if an antibody or glomming fragment could be reshaped or coated with a protein bag, to get through those channels. The big thrill there is the ability to target organelles and cytoplasm chemicals with things that work (glom to say proteins) like antibodies. The cytomembrane passing glomming structure could be linked to a drug or molecule to have a preferred effect. A longevity drug could be directed at particular organelles.

Has anyone tried putting a combinatorial library of known and new DNA zip codes on something like a optically visible fluorophore to see if there are any DNA zipcodes that localize, like at organelles, at the non-nucleus part of the cyte, even though they are not at the nucleus?

Photographers and videographers could wear video t shirts that displayed the expressions and body language they wanted their subjects to take, sort of like Smile, step forward, as changing images on shirt, kind of like cue cards.

Nanotechnology:

Build protein blankets that look enough like a protein that has preferred transport across the cytomembrane of the cyte that still have interior room to host a nanomachine. So it is sort of like a sleeping bag around a computer or something. This seems niftier than comparing a virus to a nanomachine carrier; littler size I think gives more transportability and possibly localization ability; the nanomachine could even do the organelle localization one the bag and machine passed the cytomembrane.

Genetically mdifying an organism to make nanotechnology get further faster: A custom new protein transport channel could be genetically engineered into an organism so that nanomachines coated with a preferred-transport protein bag could be transported through the new channels so they could do nanomachine things at the cytostructures.

I am thrilled there have been about 170,000 or more artificial intelligence patents since about 2010. I thought of an artificial intelligence thing and made an audio file about it.

I was sort of thinking while I typed, and was thinking about how software/AI technology could find causation. The things between the brackets are absent functionality but might suggest utility.

[[I put a thing at Quora, that there could be a different software thing, that could also be an AI thing, with finding human preferred value from data, and among those possible value forms, among them is actual causality; with the finding a third effector variable, from sorting a big gigantic library/matrix of previously published correlatable tems and equational descriptions of things. Also for more kinds of results, some of which might be better as actual results, put descriptional math equations, like time series descriptions or frequently descriptive equations like linear algebra. I think sometimes linear algebra equations are nearly identical to each other yet are describing different phenomena.

So then the thing I do not comprehend, but might if I keep typing, is can running a big pile of correlations, such that you fit more and more math descriptors of them, Do the multiple math-different descriptors narrow in on something when they overlap? Like if the presence/absence thing (null hypothesis) says the things exist, and they are both scalar 7 feet tall, and the time series data shows they sway back and forth at the same velocity and phase, and maybe a fourier analysis says, “stuff is describable as waves, if they were made of waves, they would be mathematically transformable into each other with the fewest number of possible steps of computer program execution (that is, they are more simpler); if lots of those math descriptions overlap does that boldly link the phenomena to causality. Being a little far out, I am reminded of those people that write things like the number of atoms in the universe is smaller than the possible permutations of the words in a paragraph. So if there is a really very much linked math-stack then it is possible to do experiments on it, and the software/AI is also able to screen through the math stack and its pile of correlates to find the ones that can be changed effortlessly. Then with the effortless experiment list there might be things like Does jet fuel have anything to do with air transport?; the software suggests lifting one aeliron up (near effortless) then measuring fuel mileage change. Measures of predictive accuracy of the software/AI located effortlessly adjustable things. I perceive,and I am pretty ignorant, that there might already be a knowledge that, perhaps from a newtonian view, things have measurable predictability

then as a math (maybe set theory?) thing: there is the possibility that two different causes could produce the same action, so you wouldn’t know the source cause.

So it is also possible the word cause is kind of a word that could be improved on. “cause” seems a little like making up the idea of “integers” from noticing that with two things you can put one hand on each. Quora reminds me that there are many math forms or representation and the patterns they produce. It might be that “cause” has as many variations as math, they just have not been thought of yet. Not writing that in a “golly its all so big way”, more in a: set theory, is just one branch of math, way. Omitting metaphor, it could be that there are things like a set that contains two items, contains orderable pairs, and that to order the pairs you have sequence [or] an observer, (or a rubber sheet), or possibly even an axiom. Some person might be able to come up with some system of relations like math, (I think I read math, has relations) with new forms of cause. Just to be one-track mind, sort of like the new things made possible when someone came up with rational numbers and zero.

So rather than going ineffable, there could be variations on (what I perceive some 2019 AD humans used as a word) the word cause that are actually sort of like math, and have different outgrowths of effect. Some versions, mathlike extensions, of the math-talk version of “cause” might have greater predictability at certain systems. Others might do something about how one event could have two different causes. Sort of like you see a water molecule. it could have gotten there different ways. ignorantly going for the software app,

then there is cause at databases and CS. That is a little like the math-like extension of the word “cause”. I read that the database modification sequence (some well known thing I do not know the name of) which is sort of like: load, isolate, swap, verify an absence of unloaded material, de-isolate that provides logic-based always-clean data writing reminds me of a (set theory) mathematical extension of “cause”; the nifty thing is that at Quora I read about a different way to do it than the isolate/swap/deisolate system. It was a math thing. It was like they were swapping the values of G and W without writing to a third storage variable, I think they used subtraction and remainders; one of the remainders was the variable value data, sort of instantaneously (felt non sequential when I read it). So at the math version of a variable swap there is an entire way to relate things to each other, that instead of verbs like store and isolate uses verbs like “-“ or “+”, where the variable value results are the result of a system built on at-first-glance radically unrelated axioms of generative character, that are used to generate the operators of addition and subtraction, which can then be used to do the CS database thing. So if the CS database variable swap looks like a “cause” system, that the axioms behind it are really different in composition and extensible meanings suggests nifty new ways to have “cause”, some which are,among many possible values, more able support areas where certain forms of correlation might go with causality. It is fun to think that there could be something new other that induction or deduction that might present itself if axiomatic basis of what “cause” is an equation made from could be found.

Translation: renaming the word “cause” to an extensible mathematics might result in finding axioms that look nothing like how people during the 20th century talked about cause, that generates new capabilities for humans, technology, prediction and ascribability. There might even be something other than induction and deduction.

(big more predictive math stack being looked at for “cause” finding, or other value,utility):Also, with the big math stack, I just misperceived near identicality with causality. I can press a key but I am physically quite different than a computer keyboard. The software that looks for identical stacks of math at both keyboard and me would find not very much. Although the software/AI might be better than I think, look upstream for a third variable, and say “humans caused both the keyboard and the human pressing the key”, so well written software might branch to an upstream correlation if/if not the math stack looked a certain way. What way? The certain way it is supposed to look to be a most likely to be cause among a vast plurality of correlates at a matrix/library is what I am thinking about.

One possible kludge is to make a big library of things humans think caused each other. Then have software/AI try to find patterns common to all of the entire dataset things said to have cause, most things at the dataset said to have cause, and a few things treated as isolated systems, said to have cause. Then if those computer found math descriptions of these “things that cause” [thus look like this] they can be screened to find matches of [cause looks like this] forms that reoccur at the big correlation library, then although it has a dubious “old ways/group think/cultural trance bias” the software could match the architecture of the most frequently occuring math/equations of [people say its a cause] to the big library of possible correlations. The software would see old, recent, and new or future phenomena with the old way.

]]

Research that if corrobarated with more studies and controlled for coastal effects and metaanalysis, says something like: “States with higher taxes and more government expenditures tend to have lower mortality rates among middle-aged Americans, according to new research published in PLOS One. An increase of one percentage point in state tax burden was associated with about a six percent reduction in mortality.” But the thing is how much lower mortality is produced; I have libertarian tendencies it could be that prescriptionless metformin, and development of new longevity drugs,which could be velocitized with less government regulation, could actually be an order or even orders of magnitude greater benefit to wellness, healthspan as well as longevity. Also, lower mortality amoung the middle aged could concentrate around things like vehicle accidents or cancer.

This says beneficial sleep is linked to 1/3 the cardiovascular problem(s), at stressed employed people, which strongly suggests I do things that cause unintterupted restful sleep; I read about sleep hygeine, perhaps I should see if that is effective.

Work stress and impaired sleep are linked to a threefold higher risk of cardiovascular death in employees with hypertension. The study included 1,959 hypertensive workers aged 25-65, without cardiovascular disease or diabetes. It also says of just sleep effect, “those with only poor sleep had a 1.8-times higher risk”

“Sleep treatment can include:

Stimulus control therapy: training to associate the bed/bedroom with sleep and set a consistent sleep-wake schedule.

Relaxation training: progressive muscle relaxation, and reducing intrusive thoughts at bedtime that interfere with sleep.

Sleep restriction therapy: curtailing the period in bed to the time spent asleep, thereby inducing mild sleep deprivation, then lengthening sleep time.

Paradoxical intention therapy: remaining passively awake and avoiding any effort (i.e. intention) to fall asleep, thereby eliminating anxiety.”

Possibly zero drugs in the middle of the night could improve sleep as well. Tryptophan supplement might be beneficial as well. Probiotic that makes tryptophan, particularly a well engineered probiotic that just makes tryptophan in the evening, could be a harmless cardiobeneficial sleeping pill.

This makes me wonder if ambien, which might be bad for people’s brain might cause less cardiovascular disease; not a technology, just typing things.

A study online says that plump 7 year olds have greater risk of feeling nonoptimal when they reach 11 years old; that suggests a children’s diet pill could improve the lives of children; pediatric metformin is one beneficial thing where research supports metformin producing weight loss. Also, make a bunch of chemical variants of metformin and find out if any have weight loss effects greater than metformin’s ANother possibility, that would benefit from research, which might already exist, as to if ADD treating stimulants cause two simultaneous benefits to children: Heightened focus, and possibly higher school achievement among the mentally well (non ADD) population as well as beneficial weight loss and possibly mood lifting at the 7-11 year olds that are feeling nonoptimal. It is my perception that stimulant ADD medication is well tolerated among children.

Technology: magnetic coated wires could improve motor and generator efficiency is a possible new-to-me application of, “the scientists observed a quantum effect revealing the potential to control certain qualities of the metal’s magnetism by spinning electrons one direction or another.” … “Magnetic damping is responsible for the various qualities of a magnetic field engineers use to turn metal alloys into storage devices, drive magnetic motors, and operate certain kinds of braking devices. “ Noting that charge flows at the surface of wires, could magnetic coatings, noting magnets have macroscale organized spin, and magnets have the ability to induce particular spins in things near them, cause some improvement to the magnetic effects of wire winding, like those in electric motors, or power plant generators, or does the really big magnetic field produced at a motor or generator override the effect of a thin coating of supermagnet (like Neoydium Iron Boron) on wire, right at the surface where the electrons flow? Or, is it a square of the distance thing where the field from the coating is so intense at the top 100 atoms or the like (the especially conductive part) of a wire such that the general magnetic field produced at the motor or generator winding is actually orders of magnitude lower, being a macroscopic ambience, than that of the magnetic wire coating, and thus the macroscopic motor/generator is less effecting of the spin at the outer layer of the electrical wire, causing magnet coated wires to have novel beneficial function.

I may have previously written about applying spintronic to catalysts, if not, that could be a technology where the catalyst is at a magnetic field or laser illuminated; I may have even seen an entire university study group that does this.

Nifty thought: warmth is like low grade IR, can some kinds of warmth or low grade IR synchronize orientation of spins at a material? Possibly at material depth, as IR would be generated throughout the bulk of a warm material. I think I read about something like “coherent warmth” (Economist magazine possibly) so that internal IR/coherent warmth radiation might, like a laser, orient spins; this might have spintronic benefits as well; possibly spintronic warmth could effect catalysts at bulk application without application of external magnetic fields or laser illumination. My perception is that warmth usually stochasticizes spins (warmth zaps magnets) but coherent warmth, or IR emission at the interior of a material might have a spintronic effect. One thing notes that EM/photon fields spin is linked to circular polarization: “In addition, light can carry an intrinsic angular momentum, called spin, that is proportional to the degree of circular polarization (helicity), and aligned with the propagation direction.” That is not looking compatible with IR or even coherent warmth spintronics, unless, like the way almost anything will forms swirls or vortices, or possibly even eddy currents at actual materials.

If I were a physicist I might immediately know if the bulk size (wavelength) of a circularly polarized (spintronics spin carrying) wave could be big, and possibly spintronic effects at large chunks of actual material; spintronic effects at the type of radiation, like 1mm microwave, might carry and impart customized spin at big 1mm or larger objects. It seems possible. One possibility is circularly polarized/spintronic producing microwaves improving catalysts, chemical reactions, or increasing or customizing chemical reaction yield at seperate products (like they a making a particular chemical, but the reaction produces three chemicals; Big 1mm microwave spintronics/catalysis/some other thing then effects the amounts of which chemicals are produced at a chemical reaction)

Noting there are people, scientists and technologists, on the internet that link spintronics to catalysis perhaps an electric spintronic vehicle catalytic converter might be possible; notably many things would be cheaper than precious metal catalysts

Nifty thought: evanescent wave producing structures might transport, distribute, or couple spintronics effects at two or more materials; I read two prisms slightly apart can share photons as an evansecent wave effect (I read about two wax prisms affecting microwaves with an amazing 1mm gap non-optical path between the wax prisms), so can spin effects travel as evansecent waves across actual air or vacuum gaps between materials? I just read that evanescent waves can have spin, “Researchers found that evanescent waves carry momentum and spin components that are orthogonal to the direction of wave propagation. Moreover, the transverse spin turns out to be independent of polarization and helicity, while the transverse momentum is proportional to the wave helicity”

New-to-me spintronic chemistry could be effected at millimeter or greater distances if evanescent spintronics is possible. novel catalysis at/from container walls imparting spin to chemicals as well as catalysts at the sides of a container which have something analogous to evanescent wave gap-passing energy; the spin customization magnets or lasers or some other thing would be on the exterior of the chemical container while using evanescent wave effects to do spintronics on the stuff in the container. There is a slight chance that bubble trays at petroleum refining could have some shape where the spintronic catalyst effect is evanescent-wave stimulated from photons or magnetics or some other thing at the interior of the bubble tray. The spintronic stuff migrates through the surface of the tray as an evansecent wave.

Mathematics is nifty, “light can carry an intrinsic angular momentum, called spin, that is proportional to the degree of circular polarization (helicity)” is an actual observed 3d+t effect, noting there is math of things like 4d hyperspheres, it seems like there is likely math of 4d helicity; would that carry even more information than electron/photon spin or have novel effects/characteristics? It seems possible to use math to predict what those novel effects of 4D helicity would be and then search for them at actual matter or energy materials. Noting that DQCE affects the t of 3d+t it is possible that a 4th dimensional effect of some kind could be found with the math of higher dimensionality at polarization of waves, among them circularly polarized waves. Another nifty math thing is whether waves and polarizations have different things like automatic nodality (like a circumference of a sphere might be nonself-interacting and absent automatic nodality, but a circumference on a blobby maxi pad (solid saddle curve) might automatically generate nodes or antinodes; along with different nodality there could be “size prescribes characteristics thing” or group of effects at different math shapes, like at a torus, or that wobbly thing that is not a sphere; sort of like along with the actual wavelength of the radiation/light travelling at it as amth thing, the diameter of the torus would impart a new defined thing about light or other energy “because it has to fit on the different simultaneous things at a torus”; the torus, unlike the sphere, having two or three different ways to have a circle wrapped around a diameter (circle the top of the torus with your finger; make the OK finger thing around the tube of the torus, and also the smaller diameter circle at the core of the torus), another math shape with a 4d version could be anything with “curl” like water spinning in a glass or a vortex, or even the U shaped two connected vortexes at a distance from each other I saw at a youtube video where a person made one moving a plate in water;

Technology applications of these things are: compared to a sphere model, at a torus there would be more intinsic separable states or characteristics at an actual physical material; magnetisim arises from chunks of spins, so chunks full of inner torus diameter actual optimized materials could be different from those materials optimized for outer torus circumference; there could even be materials modelled and created around the ration of inner and outer diameters at a torus; at a curl/vortex/ U or n shaped twin vortex there could be say the distance between the distal parts of the n shaped vortex as a modelled and created actual material characteristic.

Another possibility is that some of the nifty new math suggested physical effects of 4d versions of spin and helicity are 3d maps,possibly called projections, of 4d structures; sort of like that bubble-nested squares 3d thing that is one view of a 4d hypercube, there could be technologyizable actual 3d math shapes that are like the projections of 4d circular polarization or helicity. Rotini antenna: perhaps rather than a circular polarization antenna looking like a line or possibly a circle, the 3d projection of a 4d helicity might look like a rotini, notably having at least some of the beneficial technologyizable effects and characteristics suggested from the math of 4d circular polarization. Like perhaps the 3d projections of 4d hyper circular polarization could contain more bits of information, or has really good partial transmission-figure-out-what-is-says anyway; another nifty possible technology is the 3d projection of 4d helicity at laser tractor beams; I read that, something, possibly a volumetric shape made of circularly polarized light swirls and curls at physical particles to move them around, I might have read laser tractor beams were used on things near 1mm size; so is there a 3d projection of a 4d circular polarization that might do something technologically new at laser tractor beans? the 4d math of hypercircular polarization could suggest new characteristics or effect that could then be beneficial as technologies.

A new form of electricity might be possible; online it says, “Scientists already knew that light waves have an electric field that can rotate as they propagate, which is known as the polarization property of light, and that light waves carry momentum in their direction of motion. In new findings, researchers have discovered a "spin-momentum locking," meaning, for example, light waves that spin in a counterclockwise direction can only move forward, and vice versa.” https://www.purdue.edu/newsroom/releases/2016/Q1/spinning-light-waves-might-be-locked-for-photonics-technologies.html ; electrons have spin, so if this directionalizing effect also affects electrons it might be possible to make unidirectional electrons; like getting the function of a diode without a diode, a technology and physics thing is that some kinds of computer logic can be built with diodes, so it is possible the electrons could be the computer. A spin-momentum-directionalizer that works at electrons might be possible to make sandwiches out of creating a new kind of transistor where the EM fields overlap and the electrons are the transistor; that makes the electrons the entire computer, and as frequently mentioned, multifunction turing complete computers are described previously.

Some kind of thing is already known at electrons, “momentum of light analogous in many ways to the case of spin-momentum locking which occurs for electrons”

Atoms have spin; what is the effect of spin-momentum-directionalizing on atoms? Groups of atoms? New materials; chemistry?

Thinking about ways to make spintronics devices and technologies super affordable: there are a couple things that occur: comminuting chunks of some material rather than growing them semiconductor style or reacting them quantum dot style is a thought. Is there anything that could be made that when ground up would have beneficial spintronic effects and applications? Another way to make spintronic things ultraffordable is spintronic polymers and plastics; it is possible that electret and piezoelectric plastics/polymers could be custom-structured to do something spintronic and super affordably mass produced; also when I think of the piezoelectric polymer PVDF it seems like a physical action causes electrons to pile up in one physical area; is it possible to make a piezoelectric polymer that generates concentrated charge from warmth fluctuations (like brownian warmth) alone without a mechanical stimulus? That could supply electrons, or at least a surface of charge, to be used at the spintronic part This is a spintronic technology/material without wiring, batteries, photovoltaic elements, or dissimilar elements. A spintronic part without wiring could be cheaper than one with wiring and lasers. Electrets are plastics with location-fixed electrical charge, could a =O bulb terminal or | planar thing concentrate charge so it is right next to another spintronic thing or device? Sort of plane of circular polarized electrons, or a bulb of oriented spin domains, I perceive arrayed spintronic polymer might be kind of like a magnet yet made of cheap polymer - very likely much weaker than a metal magnet but still a purpose made arranged spin material. So with these grindable polymer-super affordable piezo and electret plastics that have spintronic application, one possible application is catalyst granules that could just be added to a reaction to use less energy, go faster, or produce a better ratio of preferred products, or just possibly donate and maintain charge at a different catlyst material or molecule (sort of like that two chemical sunscreen after UV regenerator chemistry)

I have not read about materials where you put the spin-customized electrons into them.

spintronic proteins, or polymers could have cytoplasm uptake and do some spintronic thing inside cytes, possibly gathering data or normalizing some cytoprocess at young weller levels.

impression electron motion, notably at magnets comes from background warmth; static

.5b It has likely been studied : beneficial technology effect of a big magnetic fields on “crystal pulling” when growing crystals and things like pure Si or Ge wafer-source material synthetically. I have heard of things called paramagnetic effects and even at water diamagnetism is strong enough to visibly bend the water, so making the pulled crystal minimally bent could be possible with magnets at crystal pulling. Really high effectiveness at going non-bendy might give a smooth monotamic surface.

Do electret plastics (or even spintronic surface ultraffordable plastic granules) custom surface charge have any effect on the velocity of evaporation? wettability might be adjustable, if you give a 3 volt electret static field on a piece of plastic a 1 volt nudge, does some water-water dipole net disruption, or possibly particle (brownian motion-like) velocity that needs 4 volts of velocity for water to break free of a surface happen from water-water dipole disruption causing vapor to leave a liquid covered surface? One application could be drying things on electret polymer surfaces, or imagining a O=O electret or piezoelectric belt between two rollers, when a belt made of piezoelectric plastic meets the rollers the interaction causes electron mobility, giving the 1v nudge. It is possible this way of drying things could use less energy; applications at crop drying could be beneficial. The energy balance does not seem to make sense, but the 3 v base and 1v nudge thing seems like it could encourage water accumulation as well, possibly improving humidifying/dehumidifying machines. Perhaps a really really hydrophobic polymer (possibly even with negative contact angle surface) that is an electret that attracts water microdroplets, just like it would attarct dust, would keep shiny and drylike while streaming water from its surface, producing water, or just dehumidifying a space. Might functiona at swamp coolers as well.

saving energy at air coolers and refrigerators: If electrets repel one charge variety of dust but attract another then whichever electret that attracts the kind of dust that is less frequent could be coated on the radiative coils of the cooler so they would quantifiably gunk-up less.

Entertaining material: the 1 meter long quantum tunneling material: I read a thing online that mentioned quantum tunneling through an insulator with like 1 or 2nm mentioned online as having ok post-tunnel usable energy after tunneling. Now with a conductor rather than insulator the electron just traverses the bulk material, so it seems possible that between insulator and conductor there is a partial conductor, even a nanoarray of metal atoms (anything from spaced monoatomic to spaced clusters of a few hundred or thousand metal atoms) mixed with filler, possibly something better than a ceramic, such that at the combination material that would be such a poor conductor that the majority of electrons got to the distal side from quantum tunneling (Note the thing midway between conductor and insulator is electron mobility smooth; this is completely different than a bandgap semiconductor)

Although, rather than a metal-ceramic mix,which I kind of think would do a lot of non-tunneling quantum level elevating hops, something like a fancy polymer could be a meter-long quantum tunneling material; it seems like a pleasant moment to mention two electron systems like chlorophyll, so perhaps a chlorophyll mer-polymer would, completely without being a bandgap semiconductor, be a really mid-value insulator and conductor simultaneously; I do not know if it is plausible, but a polymer with niftily-spaced mer-molecules causing easy-short distance between polymer molecules that are then easy-short for multiple sequential hops of quantum tunneling to occur could be a way to make the quantum tunneling material that is sort of between, yet neither of, conductor and insulator. So at the meter long polychlorophyll meter-long form the polymer strings are really near each other for quantum tunneling and the stuff is neither a conductor or insulator, but would conduct electrons through many eentsy polymer string -to- polymer string quantum tunneling events sequentially. There is a thought though: why would the quantum tunneling occur in a particular direction, rather than just stochastically throughout the material? It could be that channel and lane anisotropy at the chlorophyll polymer, sort of like cross-country skis or a bunch of engineered polymer things where the polymer is quantum-tunneling bulky on the sides, and quantum-tunneling favoring thin at the preferred stream direction; something like a lane where the center stream has much higher quantum tunneling likelihood than the sides; as a polymer this reminds me of the trees produced at some linear computational automata images I have seen, a bunch of branched valleys that accumulate water (electrons) to produce a high volume single stream.

So the chlorophyll polymer thing might function, unless of course a vacuum is the least trouble to quantum-tunnel through thing, then the vacuum would be the long quantum tunnel material, and the math that says how far an electron is likely to hop in a vacuum gives the distribution of chronologically happening observable quantum tunneling events. It at least seems like the polychlorophyll might be less tunnelable than vacuum; then again I read something about how a published researcher looked at quantum effects propagating through DNA and found some, and that they were, to my perception, seeming high velocity to the researcher.

Perhaps really cold still liquid argon with some metal atoms in it might work as a noninsulator<-> nonconductor. Well it was entertaining to think about but I think I figured out why the footlong quantum tunneling material will not work: At a conducting metal none of the electrons are raised to higher emissions quantum levels, but at an insulator, at least the kinds I am thinking of now, they have a high energy “breakdown voltage” that is kind of like hopping up the energy (dubiously: electron volts?) which reminds me of the electrons hopping up to an emissions spectral level to where they saturate something like a crystal of ceramic causing electrons to flow anyway. um, dielectric breakdown might be a quantum-hop-up level for the insulator (crystal ceramic) until enough electrons are up there to move around. so the metal conductor might be thought of as omitting quantum level changing

Although, rather than a metal-ceramic mix something like a fancy polymer could be a meter-long quantum tunneling material; it seems like a pleasant moment to mention two electron systems like chlorophyll, so perhaps a chlorophyll polymer would, completely without being a bandgap semiconductor, be a really mid-value insulator and conductor simultaneously; I do not know if it is plausible, but a polymer with niftily-spaced mer-molecules causing easy-short distance between polymer molecules that are easy-short for multiple sequential hops of quantum tunneling to occur could be a way to make the quantum tunneling material that is sort of between, yet neither of, conductor and insulator. So at the meter long polychlorophyll meter-long form the polymer strings are really near each other and the stuff is neither a conductor or insulator, but would conduct electrons through many eentsy polymer string -to- polymer string quantum tunneling events sequentially. There is a thought though: why would the quantum tunneling occur in a particular direction, rather than just stochastically throughout the material? It could be that channel and lane anisotropic width at the chlorophyll polymer, sort of like cross-country ski surfaces or a bunch of engineered polymer things (morphologies) where the polymer is quantum-tunneling bulky on the sides, and quantum-tunneling favoring thin at the preferred stream direction; something like a lane where the center stream has much higher quantum tunneling likelihood than the sides; as a polymer this reminds me of the trees produced at some linear computational automata images I have seen, a bunch of branched valleys that accumulate water (electrons) to produce a high volume single stream.

another thing about the dendritic tree-like computation automata images is that at an engineered polymer you could have differently spaced branches for the electrons to quantum tunnel to at hops; the branches are nearer and further from the most recent electron-place, so at the near branch the likelihood is say 1/3, but at the far branch it is 1/9 all the polymer’s physical and actual distance of branches together as a probability would be engineered to be (near) one.

So the chlorophyll polymer thing might function, unless of course a vacuum is the least trouble to quantum-tunnel through thing, then the vacuum would be the long quantum tunnel material, and the math that says how far an electron is likely to hop in a vacuum gives the distribution of chronologically happening human perspective observable quantum tunneling events. It at least seems like the polychlorophyll might be less tunnelable than vacuum; then again I read something about how a published researcher looked at quantum effects propagating through DNA and found some, and that they were, to my perception, seeming high velocity to the researcher.

I think an actual physicist would say they are independent, but if you have something like a flash drive: quantum-tunneling container, but have two electrodes to it, to put electrons in the container, does the doubled number of electrons increase the actual amount of energy that gets tunneled. It seems like two 1 electron volt inputs (wires) to a container would still have the combined quantum tunneling energy output as well as quantity of electrons as a one electrode system, doubled. That is the two together are absent nudging the quantum tunneling easiness amount up or a reduction from bigger plurality of electrons. Then again, with more electrons there could be more actual electrons doing wave overlap effects, that could go nodal or antinodal. There are many things about probability that I do not comprehend, but things where you adjust estimated likelihood from previous data (bayesian?) might have some relation to a couple conductors in a flash drive container system. Actually the measured numbers from a quantum tunneling experiment, and the probability models that best describe then predict them, could bring new things to know and technologize, from finding ways quantum tunneling systems might be measured as having all sorts of novel things like bayesian-like system memory, or some unexpected time distribution (poisson distribution anomaly) of the tunneling events.

Mathematics is awesome, this quantum tunneling thing makes me wonder if you can observe a physics system to observe new math (I perceive 21st century things suggest that physics look to math for effectiveness, so the idea that new math could be found from physics is kind of nifty)

If there was some mathematically previously unpredicted amplification or even decrease in calculated quantum tunneled energy amount then that could provide more things to know about quantum tunneling systems and the technologies that can be produced with them. Who knows perhaps there are detectable wake effects or slipstreaming with more electrons at the same energy when quantum tunneling occurs.

It seems likely others have already thought about it, but if you coat the interior of a flash memory quantum tunneling container with a ultra-thin layer of a conductor does that change the shape of the electron probability distribution in the container? The change to the morphology of the “electron cloud” could effect quantum tunneled resultant voltage, or amount of tunneling events per chronological moment. Also rather than just a coat of conductor at the flash drive container technologists could put varied shapes on the sides of the flash drive quantum tunneling container, some kind of repeating “wallpaper” could have some sort of reliability increasing effect from shaping the electron cloud/3d spatial electron probability distribution. So besides flash drives, which I read are more a previous thing and that the physical structures of Intel’s Optane are better than flash memory.

nifty math thing to know would be 4d topology of these other forms.

I like non-cement building materials better, as a technology though it might be possible to make cement more affordably and with fewer emissions, as well as to mitigate the appearence of cement or premade cinder block construction.

Vertical grasscrete as a possible visually ameliorating, or if it worked well, actively aesthetically perceived as more appealing than vinyl/polymer siding on things made of, or having structural cement; grass and airplants; nutrient enriched cement at grasscrete would grow algae and or moss making the cement turn green and blend in with the actual living plants at vertical grasscrete.

Highmountain phong shading/ray tracing neural networks faster way to find global and local maxima and minima at neural networks, software and AI

I do not know much, but I read things about fitting models to data at things like artificial intelligence and machine learning with names like “deep learning”; I perceive one of the ways data can be viewed, or mathematically considered is kind of like a topological map, with local maxima and minima that can sometimes make software not seek different more actual or accurate maxima or minima. Sort of like the software going to the top of a building instead of the top of a mountain because perhaps the software would have to notice and iterate through many things less tall than the building prior to reaching the mountain. That colloquial description, reminds me of the possible benefit to software and artificial intelligence of having a highest view so that a variety of possible paths can be looked at simultaneously to find an optimal one; as a human it is possible to visually view a topology and tell which parts are highest. Computationally I am reminded of the software grabbing a high vantage point then doing ray tracing on every feature at a landscape; from the high vantage point this would provide the actual maxima and minima of a topologically graphed data set, without the software nonoptimally perceiving a local minima or maxima as the system minima and maxima.

So there are some ways to computationally enhance or improve things like this thing I just described; ways to create a high ground from which to do something like ray tracing. There might be some mathematical value to just making a highest point; you could just think you know what you are doing and go with one vantage point with a Y value twice as high as any noted at the dataset. Then a person that knowsmore mathematics than I do can use this to do things like analog string-sort, lift everything, cover with liquid helium, or, dare to sometimes simplify to logic and shakeout a net

As a concept, that then gets described as a technology: Cheap liquid helium clings and flows faster all over the city and mountains and although a non-analog computed point cloud could map the topology; a possibly-instantaneous if the ICs support it: the amount and location of the liquid helium is analog-amount-mapped with a spectrography (helium noticing) laser with a wide illumination laser, possibly the spectrography instrument projects a a detailed smooth gradient (ramping) hologram everywhere all at once, or, less optimally, a planar scan laser rastering the helium covered landscape; then the results, or rather analog form-stream (urge is to just say data, but it is analog rather than digital so form stream is the word sequence) of the mass analog simultaneous chromatographic detection of concentration of liquid helium are optically-like concentrated (collimated/DCX lens) onto a thing that finds a sort of non-viewed/viewing optional map of saturation (the amount of liquid helium) then with an amplitude filter, the filter causes the maxima and minima to separate/be isolated from the rest of the analog information (like data but analog) coming through the collimater/DCX, and then the person or software or AI using the system has found the actual maxima and minima of the entire topological map.

So technologically, at an early 21st century data set that is digital, which might be supplanted with some new kind of analog data representations, methods and technologies, what is the computer equivalent to pouring liquid helium onto the landscape? New integrated circuits could do non-digital plural averaging and quite possibly analog forms of things that simulate physics. Some circuits could be based on flash drive quantum tunneling

Flash memory during 2019 AD, I perceive, had little containers with a plenum that electrons could tunnel through. It seems possible that coating the sides of those multibillion flash drive containers with a conductor, or an electret would change the shape of the electron distribution at each flashdrive unit object container;

If you think of coating the sides of the flash drive container unit object with a shape of conductor or electret, or micropatterning it like wallpaper, then each flash drive container unit can have something like a bulb shape on the container side or maxi-pad looking tennis ball parts that might combine to (have one larger than a single container) predictable cause an electron cloud shape across two unit containers or at an atrium; side coatings, wallpaper, and shapes on flash drives, analog flash drive effect, that might, or might not combine tomake geometrics that have consistenct or constructive way of “saying” a topological form or having a statistical profile of a material, like liquid helium. The coatings on the flash drive container sides and/or wallpaper and/or gradient slope plenum dividers do analog workaliketoliquid helium.

also the electron detecting side of the plenum could be analog rather than a 2019 AD 1/0 digit reporter

analog interactions, besides arising from custom flash drive container sides could be things like atriums, Hub and radiants, token ring networks, possibly even re-send-until arrives (TCP/IP like) geometries could be produced with semiconductor technology. People that are better at mathematics andcomputer science than I am could possibly describe parsimonious physical analog networks and container shapes and wallpaper that combine well to represent things; notably this might have some nifty geometry things like “kite and dart” penrose tiling, possibly networked.

There is a 1 terabyte quantum tunneling storage memory card so that is 8 trillion flash drive containers that are mass produced on an (or a thin stack) IC at 2019 AD; Note that this reshaping of quantum tunneling flash drive geometriesis different than the 2019 AD use ofthe word quantum computing

Artificial high ground math algorithms: I read about a thing where you get some branched strings, flip them twice, then it autosorts to find thelongest continuous path at the bundle of string; I perceive a person who is functional with mathematics can do this to an analog mesh representation of a group of data or a topology map, or with analog computing, an analog thing representation (like data only analog)

lift effect; analog simultaneously lift all to the height of the highest actual feature; distance or energy to lift describes minima / maxima; to find the other minima/maxima just down then lift up.

tennis ball parts; shapes on flash drives, analog flash drive effect, that might, or might not combine tomake geometrics that have consistenct or constructive way of “saying” a topological form or having a statistical profile of a material, like liquid helium. The coatings on the flash drive container sides and/or wallpaper and/or gradient slope plenum dividers do analog workaliketoliquid helium.

This seems to cause a perceptual thing where a person might think, is the resolution of the analog system the same as a digital characterization? At certain sytems it is possible that the physics-like behavior of the material the town and mountain are made out of brackets function without digitization; if you know, or the model permits, something like a statement like “a pile of minerals of a certain height and width if stacked higher than N units tall has a .99999999999999 likelihood of reorganizing to spread out; we are only doing this to .99999999999999 likelihood of accuracy” Then rather than the eentsiest distinguishable divisible resolution of the analog sensor, the resolution of the material behavior that the landscape is made out of then brackets possible heights at features of some width, and the height and width that the analog system can represent are higher than that. So it can do a functional thing.

So is it possible to do this imitation physics-like way of: bracketing resolution from the material behavior pattern at other systems. Yay logic, but I am trying to think of an analog complement, and I think a mathematician could do it, that describes the usable span and singular (math word singularity) regions of analog computing, particularly what the analog computers are actually built out of; Development of the flash drive topologically-process-linked (like undulating skate park atriums) quantum tunneling container technologies might physically make math things like a fourier equation statement of a waveform; I think fourier transform can do discontinuous waves and square waves; so can represent something like all the oscilloscope logic probes at a computer circuit board; that is digital computing can be represented as fourier equations Then perhaps combine a bunch of fourier equations into one equation, or just (dubious on this) make an array as a thing (kind of like a program) a person other than me can do great array-aware math on and with, as well as funtion as an egg carton full of program structures and instantly available oscilloscope map points. Note it is my perception that a fourier series can “say” even discontinuous functions and things like square waves. If a fourier equation can describe a square wave I think a few of them in a thoughtful pile can do the same thing as a computer program, so an analog computer would also have digital capabilities.

It is a little different, getting beyond: but one view of flash drive unit containers with shapes, wallpaper, and slopes on their sides as components could be having a mathematically aware person figure out you can use the electron dwelling (flash drive container) and electron flowing regions of an analog IC at some absence of risk of mutual overlap to minimize resolution decreasing (or said analog, at some applications or equations a fourier function going nondistinguishable from another) or nonoptimally filterizing, like bandpass filter, things at the computed solution or preferred optimal process range; Or the mathematician could come up with equations that represent reusable patterns the programmers could use to build actual working software.

That humans might be willing to make neural network analog ICs is possibly supported for what I think I read that some large companies are making neural network, perhaps massively multiparallel ICs

Those mathematically awesome humans, that is people, who can take a topological network, apply math to it, and sort of simplify it to a network, then

see if I can think of something better to replace cement, like really software optimized drones that can build things out of scraps, actual modules or components, parts of plants, and polymers with precision and software-forecast high durability. The appearance of the drone-constructed things could be highly detailed, higher resolution and quality than that a human artist could produce, so drones that paint well would benefit humans

.5B

Robots or other automated mechanisms, possibly including drones, could make polymer containerized water building things, like cinder blocks, yet better; The possibly rapid production of water containing building component units could make automation-built dwellings and other architectural objects at higher velocities and more affordable than some other appraoches to making an architectural product. I am thinking that ultrasonic welding of durable polymer film with water fill up during the manufacturing process could make the components at an automated mechanism or drone. It is possible that a multivesicle water building component could retain structural strength and durability even if there was a zapping occurence; Cornlike water vesicles with an external tube that becomes rigid is a possibility. Sort of like if you put an ear of corn in a tube, and the tube’s rigidity is increased because of the plurality of mini-water sacks that are the kernals of corn, and it makes the tube more rigid for structural purposes. So instead of an ear of corn in a tube, you have a roll of what is kind of like a scroll of water filled bubble wrap with a tube-making polymer cover surface. The automated mechanism or even drone makes a bunch of scroll-struts, and at the architectural object these are complemented with automated mechanism stackable shapes.

At cool climates water shapes could be structured to maintain function and not shift out of place even if frozen annually. Perhaps a soft polymer bag, full of air, part of each strut or stackable shape could harmlessly compress if the water froze,

Prenatal supplements, chemicals, or drugs that could be tested to see if they benefit babies and pregnant women, At quora I wrote, “There is some published material on use of arginine at veterinary food at raising birthweight, and creatine has numerous benefits at adult humans and may be harmless or beneficial during pregnancy.” Creatine causes muscles to be stronger and to grow in size, it is possible a pregnant woman taking creatine might have a stronger uterus for making effective contractions during labor of bearing children. Also, it is possible that prenatal creatine could be correlated with neonatal muscle strength and higher APGAR numbers, noting that high APGAR numbers predict lifetime well being of the person that develops from the baby. Pregnant lab mammal and monkey studies on NMN and NR could show benefit to both the pregnant woman and her baby. Also, why not see if curcurmin benefits pregnancy and the APGAR of the neonatal person, and possibly their mental and social development measured at age 5. No actual reason, I have just read curcurmin does a wide variety of beneficial things from improving healing to senolytically zapping cytes that are exporting toxins.

.5b

I am a vegetarian to be nice to animals. I am opposed to humans, that is people, wearing fur. Imitation fur could be improved to be better feeling than any animal fur. Just engineer, perhaps iteratively, polymer imitation fur, and soft fabric material that is softer and snugglier than a particular sea otter pelt at the Charleston Marine Life Center; doing better than that pelt would create a thing anyone could have that feels really good. I read that it has one million hairs per square inch, so the synthetic could have 2-10 million strands per square inch, and from an engineering perspective viewing each hair or strand as kind of spring on a pole, those spring on a pole numbers at the sea otter fur could be duplicated at the polymer imitation fur. As an imitation of sea otter fur this would feel even nicer than 2019 AD “microplush” fabric products

Write to Dave Pearce who wrote the hedweb.org online site:

MWI Many Worlds Intepretation of physics technologies and possible ideas and enhancements:

Dave Pearce: metallic porphyrins or photoactive proteins or photoactive lipids could do a thing where a numerous atom system at an aqueous environment has a photon-stimulable (linked photon detectable) quantum decoherence effect. If different metallic porphyrins have different intervals of response to the stimulating photon then the size of the molecule affects the druation of the quantum thing. macromolecules like proteins or rubber tires critqiues the femtoseconds thing and could give a quantum size of the size of consciousness different intervals.

Quantums of consciousness could be affected with standing wave phenomena, and simpler things like mirrors and resulting wave phenomena like mirrors, lenses and simpler solitons near other things, like neurons, or quantum-computer parts that cause durability of structure and standing wave phenomena as well as soliton-makers could be made from them as well. MWI might already suggest suggest that the possible recombinations of possible MWI universes from a multiatom system is larger and different from a MWI amount based on monoatomic emissions MWI amount. That suggests that the MWI amount from standing quantum event structures and technologies could be larger than stochastic MWI generators like all-atoms or stellar objects. That gives the possibility that something built on earth could make more hedonistic-imperative achieving sentiences, among those sentiences being people, that is people including humans, consciousnesses having MWI universes than other versions of MWI.

At Dave Pearce “schroedinginer’s neuron” theory producing different size standing waves of quantum effects, as technologies or searched for and possibly found, at neurons, would cause different sizes of consciousness structures producing consciousness. Notably for dave things like solitons, circular polarization, or standing-wave artifcial atom focus parabolas could cause different durations of a quantum neuron structure effect, each of these could have different technologically testable characteristics for Dave to make support/refute experiments, some of which could be easier than interferometry of part or whole neurons

It could also be that unitary MWI is even bigger from things like spherical emissions of photons around a singe photon emitted from a spherical-like electron could cause a nonfinite (infinite) number of photons path being emitted from a single photon-electron event, just one integer-size (atom atome, one electron, one photon) nonfinite electron spectral photon emissions would cause each atom to have a nonfinite number of MWI universe generated occurences. Technologically demonstating that a daouble siezed (1cm photodetector size area compared 1 mm sized photodetector) should detect more actual photon-events from one rubidium atom that is laser cooled experiencing a 1 photon laser supports an every possible photon path version of MWI; notably bigger than an every photon from a simple 1-electron one photon thought-of-event, then of course every emitted from 360 around an electron sphere makes every possible photon path, factorial at even merely the observable universe an MWI universe generator.

A size of unitary MWI electron bandwidth emission (color) event could generate a mathematically nonfinite, possibly a particular size namable amount of infinity like aleph one to be generated from a 360 sphere version of an electron to emitted.

The 360 photon emissions event and its photon re-emission causes MWI, possibly also unitary MWI, to have an all possible photons at all possible electron locations, at all the enumerable electrons size of the unitary MWI

Refutations of infinity or sizes of infinity could then affect the struture of aleph numbers and thus MWI unity at some simplest possible thing like set theory or Functors (or forgetful-functor system/structures ) statments of the math of unitary MWI.

Also technologically testable could be at thing, or another thing which is if every letter at the schoedinger equation are some, but not others of those letters, is the schoedinger equation still supported. nonfinite letters would lmit the size, or restate the unitary MWI.

Another infinity is the evaluation of a an arbitrarily large numers of math equation at a sentient gazer, or notably a macroscopic gazer big enough to view a data-meessage with sperable bits or equation letters. “hey, give looking over this equation once at a computer base, or humna equation generator makes nonfinite math for a sentieince to solve.

technology thing: one neuron, possibly with a physiociculating metalloporphyrin, is illuminated with a quantum linked photon; the illumination effects the electron distribution of the atom, which bends/effects a neuron’s chemistry, which then affects a retinal-cytes output, which is then an an actual observed photon.

The pleasant thing about his is that a cognitive being or nonconscious computer could use any of tested neuron component of Dave “scrhoedinger’s neuron” theory, different nonfinite unitary MRI (I think), restructuralizations of infinite/nonfite amounts, standing quantum wave, to build a hedonisting imperative causing and creating and apllied technology

Also, notably, I have already experienced a time technology, suggesting that sentiences at a unity-or less amount sized amount could build a hedonistic imperative an nonfinite lifespan number of preexisting MWI universes;

IF size

Could those areas of the brain that respond to transcranial DC stimulation (tDCS) be particularly easy to reach with photonic stimulkation of photostimulatable drugs because of the near area of the tisuue and the less tissue that the photons have to travel through?

Better plywood and particle board: Wikipedia describes ural-formaldehyde glue at particle board and plywood; It is possible that what might be thriftier, although I have no idea if it would be better as a material is to genetically engineer or breed wood plants like some trees to make much more sap or resin, then find a free radical catalysts that turns the new larger amount of resin to a structurally functional glue

Math: “a computation theoretical schemata for an online recursive self feeding automata which can be by way of tail recursion, which can be implemented using iteration” reminds me of how to get cellular automata based data compression to work better; Figuring out seed and tree that generates an uncompressed data object could work better if you feed the tree branches or their string generation [][][][][][] (2d data as list) back into the [][][][][] (2d data as list). so basically, grow a tree, find relationships or equations that say something about what generates what, then use those equations, as CA rules with the tree refeeding its own base seed/technique. Primitive thinking on my part and a mathematician could do better, but sometimes there are things where if you have two values sometimes there are rules/equations about what can be found between them.

So if the data is a phone book, an equation or rule set, possibly with the “ that narrows the possible tree output to things with lots of vowels or spaces between 3-10 letter strings could make a first approxination that is structurally near accurate (and with vowel frequency, statistically nearer the actual goal data-string) to sequentially refine. That would reduce the amount of CPU cycles to compress the big data string initially.

Then again, Generating a “near miss” to the data string CPU-cyle-cheaply then adjusting the seed and CA ruleset to upgrade the “near miss” to the actual specific data string to be compressed might take just as much, more, or less computation. I do not have any idea, it is just an alternative approach. So the idea is that tree-refeedback could generate the “near miss” with a test of “looks, structurally, like the data string” then just make lesser, easier to compute changes to the seed, possibly using “recursive self feeding automata” once the CA generates a structural match to the goal string, like lots of vowels or regular space characters.

This structure first, then refine approach could also decrease the number of CA tree growth increments, that is it would generate the tree with less CPU cycles. Also, it seems possible to find different rulesets and seeds and number of tree generations that produce the same goal data string. More than one way to produce the goal string. Among the multiple ways found, one could be fastest to expand (decompress) from having fewest tree-line generations.

At an automata, “Each variable in the CFG [context free grammar] corresponds to a language; this language is recursively defined using other variables. We hence look upon each variable as a module; and define modules that accept words by calling other modules recursively” http://msl.cs.uiuc.edu/~btovar/cs475/hw/recaut.pdf , reminds me of producing a durable island of meaning , where the island is the CFG, (made up of automata output and little-part stored and produced values); causes me to think, “it, the grammar, and the language, is the drift or gist of a bunch of functions and numbers that comprise it”. Perhaps a normal distribution, graphic, generating eqaution, and part/area isolating equations are a drift or gist that creates a language that says “normal distribution” Then again, that is kind of being overly broad as it seems to just restate, “equations can describe a system”. My loose reinterpretation of the word “language” at the quote is kind of just saying once you have equations of the normal distribution you can then recombine these equations as a sort of words to make completely new statements about a normal distribution (possibly also doing some exciting grammar thing where what comes first and next and possibly what/where is a verb is, has a definite pattern, possibly a CFG generated grammar). Gee it just sounds like “math says things, and the math you use to say things can be reordered to say new things and make new descriptions” which seems very very well known.

At the same paper it says, “Intuitively, if q′∈δm(q, m′), then Xq can generate a word of the form xy where x is accepted using a call to module m and y is accepted from the state q” (perhaps it is saying: where a new generated thing meets a previous stored state) The line from that paper seems like an actual parts that work and do something, actual usable math, way of saying: we generated a CFG where a variable can be placed next to another variable in a relationship. That is it generates something like an axiom of grammar, while simultaneously building things from previous stored state.

The automata that generates the context free grammer, that might be doing specific instances of, “math says things, and the math you use to say things can be reordered to say new things and make new descriptions” has one line of a multi-line description that says, “Intuitively, a transition within a module is simulated by generating the letter on the transition and generating a variable that stands for the language generated from the next state.” OK, that is exciting to read, and seems like the english explanation of the “Intuitively, if q′∈δm(q, m′)…(more text)” descriptive/defining actual math or logic-like language of the paper. It might sort of say: one part of one thing, and another previous-like thing, together make up a durable grammar (way of saying things) which is sompletely different than the interpretation at the start of this paragraph, but I will leave the first part of the paragraph as it is becuase it is also entertaining.

Dave Pearce: “look upon each variable as a module; and define modules that accept words by calling other modules recursively” The possibility of an automata generated context free grammar (CFG) functioning at systems that extend the chronological length/duration of an uncollapsed quantum state, (possibly looked upon as a math-way where CFGs could produce time intervals that cause quantum events to require different amounts (more or less amount) of observation (some interpretations of quantum mechanics) or different amounts of atom-to-atom interactions sufficient to decohere a quantum system (some other interpretations of quantum mechanics). Dave Pearce refers to some person who says the duration length of an unresolved quantum superposition is “femtoseconds” at an aqueaous chemical system like a neuron. Some technological instantiation of Context free grammars, technologically implemented as automata, could change the femtoseconds to seconds, as well as possibly effect the atom, molecule, or even tissue-span (like the actual physical dimensions/AMU) of the superposed amount of stuff. For Dave, bigger tissue/cyte/neurons being superposed for longer intervals eases scientific and technological research, where I perceive Dave wants to find the source of the source of conscious awareness (at his published at Quora version he uses “schoedinger’s neurons” as a quick memorable description); as well as new consciousness technology production.

Thinking of Dave’s “schedinger’s neurons” idea: noting that an automata context free grammer could effect the chronological length or physical span of unresolved quantum events (UQE), what would you make it out of, and niftily, entertainingly, math and science-wise can you search for multi-cyte feedbacks, procedures, automata or basically computer programs at existing proteins, cytes, and tissues, including neurons?

If they find, or technologically make, a UQE chronological interval extending automata/math relationship at proteins/cytes/tissues it could be possible to change that or link that to the naturally occuring “dwell time” of neurons, parts of neurons (like synapses and dendrites); the longer the interval of dwell time it is possible the experiments are easier and the technologies are easier to produce; perhaps neurons, as per Dave’s idea, might have some surveyable systemic relationships that could be restated as automata, or other computer-program like assemblages, and these assemblages could define the quantum unresolved time interval that these UQE last. If you find the automata/program at the neuron or its parts then you could use that computer science/math sourced expected interval to make experiments out of. 100 ns experiments, 1 second experiments, 24 hours experiments, all based on the math-predicted length of UQE at the CNS or neurons.

also, what about really long computer programs or automata; could could these generate nonfinite lengths, or even multiday lengths of UQE at protein/tissues/cytes like neurons? If Dave’s “schoedinger’s neurons” Idea has value, then finding UQE systems with intervals of hours or days could redefine thought, pre-thought, something like the feel of the day. Beyond the causual psychological observation that the mind flits from thing to thing with metaphor:variaed lighting (a metaphor for feeling or sustained nonconscious perspective): Thoughts change all the time at less than 1 second intervals while often tilted with a kind of gestalt of multi-hour (apparently) noncognitive baseline of a perspective like cheerful.

New drugs or CNS structures that change the intervals produced with CFGs or other means of effecting the UQE duration at the sentient being could create new forms of sentience. Supersentience could possibly go with more actual isness from technologizations like genetic modification, drugs, implants, or cytological sized computation technology objects. (a greater or different amount of isness contrasts with just feeling more isness from say, stimulant drugs or LSD).

From Dave’s perspective, a sentience that compares p-zombies with 2018 AD humans, it is possible supersentiences based on UQE duration modifying CFG proteins/cytes (like neurons)/tissues would create beings that think we are like p-zombies in comparison with a supersentience’ amount of beneficial isness. Also this could have sentient AI technology applications. As previously described, things with varied and lengthy UQE, per Dave’s theory, are one more possible way to generate consciousness. Noting the standing wave solitons, mirrors, and atom-parabola imitation-atoms formable from energy; also noting that these can generate things like standing waves, and that standing waves of custom frequency or duration, could have different, varying, possibly longer UQE intervals, engineerable to imitate and improve upon those human sentience producing effects at Dave’s “schroedinger’s neurons” idea, could be a new technological way to create artifical sentience, awareness, isness.

I saw a parabola as well as a circle of atoms making a nodal wave additioneffect: a new blob of charge, and the new cofocally-sourced blob of charge can act like a charged atom. Atom parabola focus chemistry: atoms as waves that can focalize; the foci imitate the charge of atoms, thus can effect the energetics of physical molecules, this could link or implement a parabola-focus energy workalike functioning as a halogen or other atom, to physically, chemically modify the reactivity of an actual molecule, the shape of a protein or the activity of a neuron). This could possibly be created at things other than neural tissue creating new technologies as well as modifications to existing technologies like semiconductors. Another possibility is that I perceive wikipedia says time crystals (plural rotating energy states as non-static least-energy configuations of atom groups) have been physically produced; these looping systems could loop through CFG UQE chronological and physical span adjusting automata, producing large, durable, technologically customizable UQE, which Dave thinks are causative of sentience. So a time crystal chemistry could be a non neural source of sentience to make artificial intelligence from.

Thinking of atom parabolas with an artifical blob that has the charge characteristics of an actual atom without there being an actual atom there: Perhaps imitation carbon, or some nifty, even more plurally-attaching electric charge than carbon variation (say 20 “-“ links per virtual atom), could form polyatomic molecules; like a virtual phenyl, or a virtual dopamine, or a virtual RNA, or new hyperplural carbon-like virtual molecules or, possibly macromolecules. These could be a new kind of organic chemistry because they could do more, new, different things than the existing elements in combination. technologies that build chemical systems, or even possibly artificial intelligence technological generating objects could have even more possible engineerable variations.

Is it possible to produce parabola-like virtual atom cofocalizers at something other than solid matter? Various gases can be spin-polarized, and spin polarized things might exhibit something like magnetic sorting or arrangement; It is just possible that spin-modified laser-zapped gases in a big magnet could produced ordered parabola-like virtual atom generators. A virtual atom environment as widely spaced as a gas could have enhanced chemical activity, and permit more virtual atoms to be next to each other for making virtual atom molecules.

a semi-aqueous virtual atom parabola, or other shape might be producible with something like a lipid layer or bilayer. A regularly spaced grid, with somethinglike metal atoms at it as part of lipid layer or bilayer might be moisture-stable. A laser immobilization field could possibly cause a big million times million or billion times billion array of metal atoms at a lipid layer or lipid bilayer grid of molecules to be constrained as to place and position. That would make a large-surface area virtual atom technological structure.

Water has a possibility of being arrangeable into virtual-atom producing structures or shapes. A laser immobilization field could possibly cause a big million times million or billion times billion array of water molecules to be constrained as to place and position, they would then be placed in parabolas or other shapes to produce virtual atoms to make things with and do chemistry.

Ladder or staircase polymers: The sides of the ladder, or triladder, or quadro-ladder each have an atom on them, then the atoms cofocalize to make an assemblage of virtual atoms that can be used at an actual produced technology. The custom shapes of proteins, as well as their predictable mechanism-like motions, notably some I have seen at cytological biological systems, could be used to make virtual atom assemblages and even do things like swing them together or hold them at adjustable lengths from each other to make things, that is, technology objects. Things like virtual atom technology proteins could go along with circular-gap graphene stacked sheets as things that can produce stuff.

Photovoltaic or semiconductor or custom band gap material made from cofocalized virtual atoms: can you change the bandgap of an existing semiconductor if you project a virtual atom onto it, or its surface? Another possibility is making an entire new semiconductor completely out of virtual atoms Notably, at images I have seen, virtual atoms are produced with near 20-40 actual atoms at a parabola; 40 atoms is many many orders of magnitudes less atoms to make something out of, a possible path to eentsier computer and artificial intelligence parts. Could virtual atom cofocalization produced semiconductors have greater stability than actual element-made semiconductor crystals, beneficially effecting structural and performance variability and possibly making them warmth nondegrading? Perhaps an atom parabola or other shape attached to a graphene grid, possibly a monolayer, or a stack of monolayers, could have greater warmth stability. Also, 40 metal atoms attached to the carbons at graphene might be less warmth-wiggly. One possibility is lithium with its 1 unit of charge, another possibility is deuterium, as the higher mass of the deuterium form of hydrogen, noting hydrogen likes to attach to carbon, like graphene, might be less wiggly as well.

The graphene grid could have big action-spaces or holes in it: So if you think of a graphene grid, with cofocalizing atoms on it having the virtual atom be at a place where the graphene grid had a big, possibly circular, 40 sided circle gap hole, then the virtual atom would be free-floating, and able to be next to other virtual atoms, or even effect other molecules that drift through the 40 sided hole. That produces a custom reaction and building space with virtual atoms. A vertical | virtual-atom polymer could be constructed in a stack of 40 atom hole graphene monolayers.

Obvious to say, but virtual atoms from things like parabolas or other shapes could be effected from externally applied charge or proton movement (protontronic charge) that might make them brighter, less overbearing, or more stationary to benefit reactivity, positional stability, Plasmonics would be a technologically more sophisticated way of doing things with virtual atoms that uses electrons or protons to enhane, improve, and create new effects from virtual atoms.

Could cofocalizing virtual atom producing parabolas or other shapes be produced from phonons or other plasmonic structures at STP? A migrating or standing plasmonic structure that cofocalizes atoms and electrons as waves could make virtual atoms like virtual halogens of virtual carbons that could possibly be electronically or protonically moved around, causing control of the chemistry and electrical characteristics of the virtual atoms. You couldmove stuff around, which could go well with atom-sized manufacturing. Could a plasmonic virtual atom-migrating technological object do nanoassembler activities?

Could a virtual atom sturalized coating or layer on a photovoltaic cause charge optimization to either improve electron migration or photon absorption. A ladder polymer or graphene coated surface, or something like laser etched, texture of virtual atoms could heighten phovoltaic efficiency. Similarly other things that generate electricity might benefit. Perhaps virtual atoms could affect the magnetic characteristics of a material.

Electrets (things like permanent locational charge materials or polymers) are a known thing, so parabolas-or other shape that generate virtual atoms could be made from electret materials. These could be stronger, more effective, higher reactivity, purposefully optimized reactivity, or notably durable versions of virtual atom technology materials. Perhaps it is possible to populate the surface of graphene, or modify a protein or ladder molecule so it is an electret, then graphene and protein, ladder molecule virtual atom technologies could have higher and durable energy. I do not know where electrets get their energy, I perceive I read that non-zero warmth causes atoms to have electrons above the ground state, so it is possible ambient STP or even cooler could keep the energy up and available at an electret virtual atom technology or chemical effector, even though it was interacting with other atoms or virtual atoms. Than contrasts with piezoelectric plastics and ceramics which, I perceive, happen when molecules or crystals respond to squeeziness or new molecule position to cause bunched up electrons.

If Dave’s theory of “schoedinger’s neurons” has value, or if adjusting the UQE interval or physical span has effects regardless of Dave’s idea, there could even be new drugs that effect the quantum superposition UQE interval of tissues, cytes, like neurons, or proteins. Just as measurable things, perhaps not effect forecast from theory, or with Dave’s idea, these could have new medical effects or modify thoughts arising at a human, that is person, or people’s brains/CNS actual physical brain or at an AI technology object. An MWI active drug.

What happens when you put an electret layer under or on top of a semiconductor? Permanent bias at a transistor?

Easy-trigger custom bandgaps, from partial pre-loading of electrons, (or I suppose things like their tunneling or availability, or blobby HOMO graphic of charge-at-molecule adjustments) at light emitters and photovoltaics? Non-polymer chemical vapor depositable electrets could enhance semiconductor technology.

“DSP circuits, such as finite-impulse-response filters with fixed coefficients, you can build constant-multipliers which multiply by a constant” makes me think there are amazing sort of analog, but possibly digital, IC circuits out there that multiply something with a coefficient. What is a way you could multiply something with (the coefficient) at an IC? I am thinking it is likely a square wave encoded thing that is being multiplied, otherwise you could just use a transistor or op-amp, but the idea of a dedicated multiplier made of semiconductors that is nonlooping, that is not a turing machine, is entertaining. I have no idea how it would work. Maybe if you do something wild like XOR (or some more actual thing) the first three bits you can do predictable doubling or halving, then progressively double or half the number-containing byte-word as fractional diminishing fractions (like 1-1/2 -1/4-1/8 from sequential xoring) to get a new number that is multiplied with an arbitrarily sculpted number that is the coefficient. The sequential XORing, if the coefficient was fized and known, could be a in-semiconductor ladder of sequential XORs (1-1/2-1/4-1/8-1/16 etc) made out of little lines at a semiconductor to create a physical coefficient multiplier of digital data, as compared with a CPU-style turing machine looping thing.

.5B Children’s nootropics: well, they could test the various racetam nootropics on mice to see if any of them live longer from the human “more education causes better healthspan and lifespan” https://onlinelibrary.wiley.com/doi/full/10.1111/1468-0009.12372 correlations being supported with a control including study on mice. It could be that being nootropic fed your entire life makes you live longer and be healthier; if it works at mice, then that, with the human correlation, and the actual measured lifetime and healthspan of the mice compared to controls could cause the racteams and other nootropics to be a positively additive beneficial variant on: measures of safety; and so recommended as a health, wellness, and cognitive thing for human physiological children to take and do.

Also, the mouse data might vary as to the improved healthspan and longevity with each different nootropic molecule, that would cause certain nootropics to be preferable for human physiological children’s use.

If nootropics make mice weller and longer lived, possibly from the education effect they could use localized versions, like antibody linked, or high AMU polyglycine linked (does not pass the blood brain barrrier) racetam nootropics to concentrate the nootropics outside the CNS,or at specific organs and tissues, to see if the different ones had any different effects on healthspan. It might find organ systems, which when their neurons are more/differently active, work better. That might find wellness or longevity producing nootropic molecules, usable as drugs, which omitting a CNS education effect, still heighten wellness and have longevity effects.

A paper says, “Although it is well established that educational attainment improves health and longevity” https://onlinelibrary.wiley.com/doi/full/10.1111/1468-0009.12372

The beneficial effects of education on longevity and healthspan might be concentratable and increasable with isolating and studying actual education content and education-environment variables like area of education, classes taken, or major, and electives and possibly education style, like homework completed or educational software hours used, as well as things like dorm residence and recreation activities at college and high school, and possibly at younger ages as well.

Pondering the effect of education on younger ages, it is possible that although almost everyone goes to elementary school, that the trends noted at high school students elective activity could produce data on which areas of interest, and their practice, increase longevity and healthspan; it is possible math classes might have high correlations with greater lifespan and healthspan, so perhaps kindergarten could be enriched with logic based on the measurement that studying logic provides lifetime longevity and healthspan benefits at the lifetime of high school and college students. At kindergarten activities like “what things go together, with physical venn diagrams, putting blue and green people and green and blue trees on different venn diagram play boards where one has intersection of people and blue, and another has green and trees, and the kindergarteners being able to point out,possibly with personal entertainment and amusement, things that “can’t make sense” when a set of characteristics or postulates is given first. Lewis Carrol might be on to something with the entertainment and puzzles Alice, of Alicein wonderland pondered.

Just thinking about college majors they might find that Math classes correlate with longevity and healthspan notably when wealth increase from the math’s enabling lucrative majors is compensated for. Similarly, they might find that sociability in college, causing more rememberable occurences of what has been called “the college experience” has correlation to longevity and healthspan when also factor compensated for extroversion. Perhaps living in the dorms and going to a mid range quantity of parties, rather than few parties or lots of parties, is measurably correlatable as physiologically beneficial throughout the lifetime.

If they find school educational and activity things that transfer well from college versions to high school versions, perhaps specific area college healthspan and lifespan benefitting activity correlations could be used to improve high school and junior high school as well as elementary school with study subjects and activities that heighten longevity and healthspan copied from university.

Although occasional spurious correlations at the components of education and school-lifestyle, are math of probability predictable, it is possible area-specific correlations of longevity and healthspan from what things are studied, how much homework is accomplished or the amount of educational software modules that are accomplished, and also social activities that are often linked to educational environments could guide some of people’s voluntary educational activities.

Curricula could also be improved. Students with a high software predictable likelihood of having unwell post-school life lifestyle could be encouraged to take electives correlated with better physiological well being. Besides subjects teaching style could have supported correlations with lifepsan and healthspan. So perhaps a class where people fill in workbooks during class time has the same correlation with physiological benefit as homework at those students who actually do their homework outside of school. The students the software predicts might face below median predicted lifetime wellness (perhaps their parents are unwell, or they have been suspended twice), could be encouraged to take an in-class workbook version of a class if the software predicted they might not do their homework.

Research on the education effect on lifetime physiological benefit could also see if it is possible to divide the benefit into measurable non scholastic researchable components like: “the feeling or sustained emotional flavor of the school experience; was school fun and interesting?”, measured self-esteem from perception of the social subjective value of their educational attainment (I saw a youtube video that said being known to have a college degree causes others to place the person in higher esteem); similarly those that do not complete high school, during the 20th century AD, might feel less spontaneous optimism about the things they can do if they feel like it, The effect of actual knowledge, or missed knowledge: treatment by others as well as perception of other’s esteem based on the social effects of how much knowledge they actually know or retain from school.

There could be many other non-scholastic components that are measurable and correlatable with the physiological benefits of education. Finding these creates the possibility of benefitting people’s physiological well being from activities different than scholastic activities, non-school based activities that are voluntary. Perhaps some meetup.com groups, coordinated delegation and activity participation at community volunteering, doing crafts, or independent reading could have workalike effects to the physiological benefits of education.

They could also research if certain styles of employment are predictive, and possibly controllable at experiments, of lifetime physiological benefit. Noting different people feel different ways, think different thoughts, and like different things, such a study seems likely to benefit from some kind of quantified cluster personality characterization measure like the big five personality test, with numbers treated as isolatable numeric clusters (extroversion numerically measured as 80-100, as well as extroversion 60-80 and others) as a way of quantifying personality when finding out the effects of various forms of employement on lifetime physiological benefit. A possible result of this research is actionable items and wellness and longevity career enabling and beginning certificates.

For the people that do things on purpose (likely high on big five conscientiousness), there might be a new or freshly advertised as awesome, career certificate attainable in less than a year, that create a career that confers a greater lifetime wellness and longevity benefit than even a college degree.

I read that people change careers with some predictability, so the employment certificate that correlates with more physiological benefit than some kind of median university degree, could be researched as to lifetime effects from just a typical duration at that career.

Using 300 hours learning and practicing at having fun has value.

Learning to have fun has tremendous value, and that people could benefit from experiencing advertising promoting being taught to have fun. It is possible the behavioral psychology of shaping young physiological children like kindergartners to practice and learn to have fun has lifetime value. I volunteer sharing and teaching reading at two elementary schools. One group is kindergarteners and the other is first graders; perhaps I could foster social styles, as well as mental activities like practicing to be fluent at creativity, like having them make up a new story from the images at the books.

Rent a friend, similar to talk therapy for the mentally well, So noting talk therapy is published as benefitting just 20% of the mentally unwell, then if, among the well, rent a friend talk, which might work for 20% of people among those it actually confers benefit on. I favor social companion robots that cause feelings and experienced well being at greater than the meaured 99th percentile of actual human friendships and romantic as well as sexual relationships.

Another way to describe a number, the kind of number economists might use, for the value of a 99th percentile at causing happiness companion robot, is to look at the correlation between money and measured happiness that occurs at those who gain money who previously had less than $70k each year. If going from 50k to 70k raises happiness 20%, then a companion robot that increases measured happiness 80% has the number $80,000 of equivalent-to-getting-more-money-value. Noting multi-year life of robot mechanisms and computers, it is possible the companion robot provides the happiness value of 800,000 to one million $ of actual money gained by the person. Notably it is possible the social companion robot that causes 80% greater happiness could make more than one person happy. If it makes 2 people, and 2 human physiological children 80% happier, then comparing it with the value of money at producing happiness, the equivalent money value of the social companion robot is $1.6 million or $2 million, with the equivalent money value to the human physiological children going unmeasured.

Note: I read that below $70k annual money amount a year, more money gain heightens measured happiness;

Among persons already above $70k at annual money gain, they did not gain greater happiness when gaining money above $70k at the United States. I think the $70k study was published near 2017 AD or 2016 AD.

People with quantitatively measured as different personalities (like different clusters of responses at the big five) may have different responses to gaining more money annually. It is possible to imagine some persons continue to increase their happiness up until $100K, while others may not experience greater happiness when they go above $50k.

The personality-sorted value of things that cause greater happiness can be used to adjust the value of a: thing or activity’s benefit to a particular actual person with a measurable personality.

The value of things, activities, rent-a-friend (Rent-a-friend: perhaps something like therapy, but for the mentally well), or social companion robots could be found for different personalities. Also with a personality measurement is seems possible to find out and have research on what big five personality clusters are most heightened as to their happiness with companion robots.

It is imaginable that a numeric measure of thrillingness that a person feels while having a romantic crush with some amount of actual interaction could predict the amount of happiness a social companion robot can produce, with a happiness causing romantic crush utilized as baseline,with the companion robot causing greater happpiness than a romantic crush. This is from me having a crush on the human Serina, we only talked some. Noting the heightened happiness from my feelings and the thrill of thinking about Serina, if it is possible to have a crush on a companion robot, with an actual 99th percentile of producing happiness from conversation, and other activities, possibly among them making out and sexual activity, This would raise happiness levels above those of having a felt as wonderful human romantic crush that is thrilling and happiness producing with fewer words of conversation, moments of companionship, and less physically-appearance-hypnotizing effects than a companion robot produces.

I support people, that is humans, being alive and being eternally youthful with death optional.

What is 99th percentile of beneficial at educational software? Noting there are thousands, or tens of thousands, or even higher numbers, of pieces of educational software 99th percentile could be hundreds of different programs Also at educational software how much statistical variance at educational software products, are they all pretty good (narrow distribution), or is there a wide distribution?

A mild, beneficial drug, possibly a nootropic could heighten moving vehicle, like car enjoyment, while producing the education effect on heightening wellness and healthspan or other from non-education wellness healthspan effects. As long as it was mild, and statistically minimally misused, it could be popular, This drug could also be studied as to its effectiviness at improving school scores and achievement as well as Increasing the longevity and wellness of mice, could support its use and parental perspective based on more safe than safe wellness longevity effects. It is possible that racetams, tyrosine, which might be nootropic and ispublished, atleast once, as anti-fatigue, could reduce vehicle accidents. The emphasis is on a beneficial drug that makes people more intelligent. The longevity drug and mild stimulant deprenyl might make drivingmore enjoybale and becorrelatedwith fewer accidents.

A nootropic with the education effect on longevity and healthspan that is an aphrodisic could be popular among teenagers, tweens and adults. Foxy (5MEO tryptophan or a similar chemical name) linked to a racetam molecule might do it.

The idea of a nootropic that heightens positive emotional amplitude is novel to me. People could feel more in love, yet also be more intelligent. I do not know what an actual human taking something like phenylpiracetam experiences if they are in love and hanging out with their loved one. Less? More? Different? Stimulating nootropics like caffeine enhance sociability which could make romance feel even nicer. So perhaps a stimulant nootropic that heightens positive emotional experience could have simultaneous benefit.

Human physiological children’s nootropics: Fish oil in school lunch has been previously described, perhaps there are amino acids that do something beneficial, Tyrosine may be a nootropic, and is published as anti-fatigue. Tyrosine should be measured as to any effect on non-prosocial behavior before being added to school lunch or breakfast. Arginine and creatine have various published benefits although I do not know of nootropic effects from them.

Novelty and notability permitting software:

“At a deeper level, the algorithm was sustaining the biases that already existed in the [medical school] admissions [essay reading] system. After all, Franglen had tested the machine against humans and found a 90 to 95 percent correlation of outcomes. But by codifying the human selectors’ [previously established but at-that-moment-of-time socially contested] practices into a technical system, he was ensuring that these biases would be replayed” Ok, say the MCAT measures 10 things, each with a different correlative efficacy at predicting medical school success. The software reads the written essays, and stuff that is reallly differerent than the usual success pattern is separated, then the essays computed numbers are compared with the 10 MCAT success correlative predictors as to their actual efficacy at predicting medical school success, if any of the 10 mcat areas, or possible groupings of them, are more highly predictive than the correlation of success from the essay, then the MCAT score can swap out for the essay, causing admission at, notably and just at: the people the software thinks have unusual, bizarre, or highly novel essays. That way if someone turns in a comic book for their essay they still could be admitted. They could measure if it works based on graduation/grades of the novel-essay admitted. The idea here is that this is sorting software that permits social and institutional change even though perhaps some previous software might have reinforced previous perspectives and attitudes that could be replaced with more optimal things.

If: essay bizzare at 95th percentile of bizarre

then: give MCAT more say.

An online site about VR headsets says they are $400 during 2019 AD, it seems likely they will become more affordable. I wonder if they can be reconfigured to measure eyesight (eye exam) and generate an optical “prescription”, apparently they might be able to do interpupillary distance figuring-out.

There is what might be a virtual reality (VR) educational/learning software thing where people learn and practice conversations that might be less than pleasant or enjoyable (terminating someone from employment) to reduce stress and improve outcomes (it did not mention body language but that could go with VR; notably eye contact and possibly hand on body position). Parenting practice software is likely to be beneficial as people generally learn from 99th percentile of child happiness, achievement, and well being parenting styles, notably they could link it to measuring your child’s personality and your own with something like the big five psychology test to give the VR user the ability to optimize their child raising and enrichment and happiness producing practice sessions

At the big five personality test there could be extra tests, or even software activity things, that partition score clusters into areas of specific tendency or meaning. Varieties of extroversion or varieties of introversion: At the action of saying fewer words, introverts might be calmly not talking, might feel not able to “get a word in edgewise”, are possibly not mentally spontaneously generating conversational content of their own, are concerned about the other’s feelings if they say something emotionally moving or controversial, eager to please but do not know how; So it seems possible to have big five score cluster “type” partitions that could benefit users that are sorting people into behavioral types (education: why isn’t Ludwig or Elise talking in class? Big five partition test describes, with high correlation and validity, what their introversion form is).(note:since it is actually academic school, centuries of prior school strongly suggest that if they are learning things and can be measured as having learned well they are doing fine, even if they do not socialize or respond to the teacher much. I strongly support academic achievement. Other kinds of beneficial education also exist. At talk to your crush school that teaches how to talk to your romantic crush, a partitioned measure of introversion could isolate areas to improve, or habits to somehow swap out.) Partitioned area measures at the big five personality test or something similar could benefit test takers as users (“I took the big five and found out I am an extrovert, so am I a charismatic extrovert or big-presence conversation leading extrovert, or a call my friends first friend extrovert?” Knowing partition contents could, just possibly, assist people to shift their personal feelings or their likely effect on others while still remaining introverted or extroverted, if that was what they felt like remaining as.

spintronic cancer drug: big magnet causes something like a chemotherapeutic drug made from nuclear spintronic chemistry to only be active when it was spin polarized; the magnet placed near the cancer causes spins to align just at the cancer area.

Dave Pearce “shroedingers neurons” way of looking at: if observation, notably from a superobserver, changes content and span of sentience, thoughts, and feeling, as well as other things: superobserver mechanism like 8 trillion elements (flash drive IC technology) is used at a person, voluntarily, to observe the quantum states, and perhaps resolve them from superposition (Dave’s schoedinger’s neurons idea) at the person’s own brain, or other parts of the body; The superobserver causes quantum resolution superposition resolution perhaps billions of times faster and with trillions, or higher, of parallel observations. From Dave’s “schoedingers neuron” idea, if superobserver observation changes isness, sentiece, feeling, as well as possibly quantitatively measurable effects of (like external action frequency change), I do not knowhow to distinguish the observation and possible quantum resolving effects of getting a MRI, notably at the CNS, from possible spintronic chemical effects on the CNS, although if magnetic fields are constant among MRI, increasing the computer resolution at specific brain areas like the nucleus accumbens could function as an observer resolving of quantum superposition

Dave: write up the things that can verify.refute/enhance Dave’s “schoedingers neurons” idea as a Quora item.

If There is a quantum component to beingness and sentience and feelings and other things, then a brain-region specific superobserver could optimize things like nucleus accumbens activity and activateability, as well as even possibly neurons of a certain type like dopmaine neurons. Perhaps a parent can benefit their child when they view an MRI of them, or utilize a superobserver with software made to benefit the child, that notices everything that is going right, to make it go well more durably. Being superobserver directed with software it might evenbe possible to make a few billion or more observations where the observation only gets written to storage if it goes right; also, (8 trillion item array at a flash drive; many voxels at fMRI)If there is a quantum resolution component to isness of being as well as a way to enhance and durabilize biochemistry thena superobserver that diagnoses only well being and capability is beneficial, also pleasant tointeract with and hear from. There could even be software weighings of how much to observe based on a sample. Some things might be more chemically active after superobserver observation, so those that are beneficialtohave more activity at would be observed; some chemicals, possibly cholesterol, has cardiovascular effects, observing those into chemical activity and durability would likely be nonbeneficial. Superobserver samples and then avoids superobserving a physiosystem or mental biochemical thing which has a data trend of: its better not to instantiate and durabalize some system, chemical, tissue, protein or other thing.

Also, there is sampling a system to see if the trend is going well, and if the trend is not going well, to omit observing it at any amount greater than the 1 part per million or billion sample superobserved.

a superobserver viewing things going right, with the directing software having a purpose of causing greater duration of well being and capability, could be a medical technology among people of all ages. Rather oddly, a big magnet, and or a mechanism with computer superobserver could be a veterinary technology as well. agriculturalists could MRI their chickens, going with absence of MRI resolution at areas they prefer to minimize observer effects on, but perhaps really emphasizing myoglobin molecules existence at the chicken, causing them to be muscularly advantaged thus more edible.

Dave’s “schroedinger’s neurons” drug; spintronic chemicals, among them possibly the longevity increasing spin trap chemical N-tert-alpha-phenyl-butylnitrone (PBN) I read about, could be concentrated and or localized as beneficial or harmless agents at the CNS and the rest of the body;

as to Dave’s quantum observer effects they could test: spintronic chemical/contrast agent with active fMRI, placebo contrast agent, no spin effect, fMRI of less resolution, fMRI at reduced software resolution except brain region of interest,

for dave: when you observe one part of a quantum system, are the other parts you omit observing or measuring affected? Like, if I weigh a quantum computer, does it effect the qubits? If I find out how many degrees K it is at, perhaps receiving warmth photons it emits without sending any interrogative photons, does that data resolution effect any of the quantum superposed,possibly electron things that make the quantum computer function?

I read that different quantized things, notably matter, energy, and everything, with the possible exception of information and presence of being describable at physics as waves, can have different areas of separate observation, weighing and scanning the photonsof warmth emittedfroma quantumcomputer does ntoa s far asI knowresolve it. I actually thought it was theother way, like if you have an electron emit a photonthe electron got immanentized, having things like location and velocity. There might be some observations, or observation methods, like electrons or photons meeting a semiconductor, that observe numerous systems or characteristics simultaneously, there might be others like measuring polarization, spin, even frequency and wavelength that leave most of the quantum superposed thing, mostly unresolved.

So for Dave’s “schroedinger’s neurons” Idea, how many observables or measurables are thereat conscious being? Like with light there are a bunch: polarization,spin, wavelength, frequency, likely others. So it is possible that at Dave’s idea, if quantum things have anything to do with consciousness, that there might be a list of observables or adjustables.

If there is separation and noninteraction of quantum measurables which produce specific quantum resolutions from superposition, it is possible there is something that when observed is beneficial, above average of all other observations beneficial, so observing it more, would, cumulatively, benefit humans, that is people; I do not know what causual easy observation accomplished with a human body that would be above average at conferring benefit to the human would be. Superobservers with software guidance that confer mental, physiological, possibly system direction/dynamic flow paths and velocities, and wellness benefit are describable.

Along with something like fMRI, which apparently looks at atoms, EPR measures electron spins. So, observations, from people or superobservers, that effect consciousness and presence of being might be shown to differ between the two (fMRI, EPR) suggesting different ways to technologize benefits, also, for Dave, thismight come up with two components to consciousness, or even reduce the likelihood ofoneof them mattering. I read there is an area the size of a quarter at the brain, and researchers “turned it off” at a humansubject who then acted like aP-zombie, she might haveeven said afterwards she was absent presence of being. So if EPR and fMRI are each used at separate procedures to observe, thatis possible quantumresolve, the quarter sized area of the brain, and fMRI does something but EPR does not, then a consciousness researcher could say, electron spin is absent a contribution to isness.

Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials with unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but it is electron spins that are excited instead of the spins of atomic nuclei”

These quantum observer dopamine effects could all change the experience of conscious being, yet there is still no presence of being, unique sentience, and isness content! I just quantum resolved my dopamine receptors and they are now chemically more active so I feel different. It is possible I might think of something, possibly a mathematics thing, an eigenvalue is possibly a word for what is constant even if all the array components change; I should rereadwhat Dave Pearce thinks, what is the sourceof Dave thinking quantum superposition is linked to presence of being.

One thing I perceive Dave thinks is that the experienced being and mind is made up of uncollapsed quantum wave functions, that is a bunch of superpositioned thingies, likely at the CNS, are making an interpretation of various (potentially various, a planetfull of things could be one big quatum unresolved superposition) other superpositioned thingies, outside the body, and that as a continuously adaptive and adpating system, similar to a genetic algorithm, the uncollapsed wavematter of consciousness has accumulated preference among humans, that is people, for acting, and even believing, things outside the body have non-superposed, nonstatistical natures.

Noting the idea that fMRI of the brain could cause observer effects on what Dave might think of as superposed unresolved quantum states at hte human body, especially the brain, it is possible that neurotransmitter-receptor active drugs that have been radiolabelled to be visible to a Positron Emission Tomography (PET) brain imager could provide benefit. I think I read there are 30 neurotransmitters, if receptor-attaching and radio-labelling for each of these 30, then viewing and even storing the tomographic output has any measured perception and/or performance measurement difference from being dosed with the same amount of non-radiolabelled, unimaged neurotransmitter activator then it is possible that that particular neurotransmitter, or its neural type or connection, has something to do with presence of being. If the result happens that two of the thirty neurotransmitters are linked to observation-based mental effect change, then a map of all the neurons where those two neurotransmitters are together at one neuron, or where two neurons, each with one of the two effect-showing neurotransmitters, that would physically map at the brain the things where consciousness was modified with observations of a system, and Dave’s thought is that observing the system causes quantum resolution. An fMRI version of this might work with a contrast agent, like a gadolinium atom, attached to each of 30 different receptor-activating/attaching drugs. I perceive the resolution of fMRI is higher than PET, so the observer effect might work better at the higher resolution.

Like the AFM quantum resolution of the length of an alkane, do quantum physicists who described things larger than continets as being superpositions of unresolved states, have a highly functional explanation of 3d space packing? Like if there is a tree, and it goes unobserved, it still has seeds inside casings, so like quantum nondeterminacy seems to permit things to be various prepositions to each other like around, above, and It is my perception the human observer can observe just part ofthe tree as a system, resolving just some things about the tree if they like, yet there is a 3D thing going on,

(I read about a spin trap drug called PBN that heightens longevity. I do not know if it is a spin directing or conserving chemical; I do not know if it is a spintronic material. Being called a spin-trap it seemed like it but I do not know.) It might be that a beneficial Electron spintronic drug, like the longevity spin trap drug PBN, has different effects when spin at the human’s body is majoritized at a particular spin, possibly with an MRI sized magnet or possibly some other magnet, or a laser, for dermal youthfulness; Although there are spintronic chemical catalysts, it is possible that spintronic published things,like spintronic polymers, could be modified into pharamaceutical drugs; also vitamin B12 has a cobalt atom;it is possible that at MRI it gets spin polarized from a magnetic effect, even though it is only one atom and not a magnetic-domain sized thing; noting lengthy nucleic acid polymers, that can be macroscopically big and even visible to a human, is it possible that a harmless and beneficial metal containing amino acid polymer with like magnetic element Co, (or possibly Nd is physiologically harmless), on it could have a highenough AMU to produce durable magnetic domain effect locally, like at different areas of cytoplasm or intracyte fluids? The magnetizable metals might cause durable up spin at the nucleic acid polymer.

Also, it is just that I have not read much about spin chemistry, I perceive there might be many nonmetallic organic chemicals with spin effects, possibly some with durable spin polarization; one possibility is if electret polymers have spin because they always have surface electrons at a particular charge; perhaps there is even a manufacturing technique that could spin polarize an electret or other polymer, besides a chemical technique; like if you are making an electret polymer from some melted plastic, and do the thing they do that makes it anelectret, while simultaneously having it cool illuminated witha laser or cooled at a magnetic field, perhaps that causes measurable durable spin at the electret polymer. If the lasers and magnets during cooling thing works it could also be a spintronic drug manufacturing basis, notably at polymer drugs.

I read about spin, electron spin is, at wikipedia, a free radical thing; atomic spin, which might be called magnetic spin, is a function of the nucleus. Technologists are able to make things like chemical catalysts and light emitters with what is called spintronics. Noting that chemistry is adjustable with spin it seemed possible that there could be spintronic medical chemicals, I feel doubnt about electron spin chemicals as free radicals, are, as far as I know, to be avoided physiologically, and nuclear spins, although MRI is published as affecting cehmical reactions, seem like the actual chemical behavior of the molecule on its own would be the largest biggest effect. Notably though, MRI does effect chemisry, and there are spintronic chemical catalysts.

Are there any spintronic chemicals that transfer or predictably modify spin at another chemical they react with, or at something like a protein, attach to? Spintronic chemistry and things like spintronic catalysis suggest: possibly. That would be like a spin donor, a synchronized spin donor enriching Up spin, if it somehow retains spin through aqueous digestion and membrane transport, possibly the longevity spin trap chemical PBNmight (or might not),

There could be physiologically active spin donor chemicals, therefore screening all the GRAS and FDA drugs to find out if any are spintronic chemically active or spindonors that are already immediately available without effort, could be beneficial.

Then, noting the previously published spintronic,notably chemical spintronic literature is a place where beneficial pharmaceutical development could find source molecules as well as previously published effects that could be modified, amplified, or adjusted to be new pharmaceutical drugs.

Is there any spintronic drug that effects cardiac function, blood sugar or prevents cancer or is a senolytic; cardiac: vagus nerve activity improver spintronic drug: could the longevity producing spin trap molecule be chemically linked to a neurotransmitter that concentrates at a beneficial physiological system, perhaps localized to the vagus nerve? that could bring spintronic chemistry and drug effects to the nerve that controls the cardiac thing.

occur, there is theentire previouslypublishedliterature on spintronic material, including chemicals.

Dave’s thing: although nuclear (nucleus) spintronic chemistry exists, it is possible spin customization of molecules, cytostructures, and possibly lipid rafts and membranes at various areas of the brain could be used to heighten observer effects, at resolving quantum systems, with the higher resolution produced at an fMRI from a spin effecting contrast agent. Also, seeing if Dave’s “schoedinger’s neurons” thing has experimental support, the rest of the fMRI of the brain, other than a region previously studied as linked to some ability, feeling or characteristic, would be purposefully scanned at non-quantum resolving digital resolution, so: at a aprticular person, everything but the nucleus accumbens has minimized fMRI data, that observes,possibly kind of superobserves the nucleus accumbens; does the person feel any diffferent; is there an effect if the human getting the fMRI views and guides the process,or is it quantitatively measurable as equally effective or functional if a researcher views it; for the non-human observer interpretation of quantum physics doing different scans, at different resolutions could come upwith graphable curves on fMRI resolution and quantitative measurables like the fMRIed human doing math, or new ideas per minute generated, or even subjective well being measures.

I do not know how it would go; technologically a superobserver, like a computer, that was able to raise human function even without the human being attentive would be easier and likely reach even more people than something where people had to pay attention to themselves.

The fMRI or particular CNS that is brain, at various regions, with heightened observer effect from the fMRI is distinguishable from the possible spintronic chemical effect of the spintronic contrast agent or other spintronic drug.

Quantum superobserver could also be a nootropic effect, superobserver observes the hippocampus optimally and that affects memory ability, if as Dave thinks, there is a “schroedingers neuron” thing going on.

GRAS chemicals and all FDA drugs screened for existing nuclear spintronic character; molecules that favor or have a particular spin more than others could be listed out then math correlated with shared physiological effects; correlate spin at various physiostructures like lipid membranes with physiological wellness; feed the GRAS/FDA drugs that have spintronic preferentialization of concentration of a particular spin; find out if spintronic effects at c elegans at automatic process multiwell plates to see if some kind of spin effect affects physiological wellness, and longevity;

MRI fields are published as effecting biochemistry, so big magnets might be causing spin polarization at the physiological body causing effects, some of these effects could be beneficial.

[[Are there any naturally occuring physiological things that have a spintronic component? Noting that things like two photon things like chlorophyll exist, and that lipids might be customizable to be spintronically having of different characteristics, and noting that lipid membranes and lipid rafts could be spin-durable because they make their own insulation from aqueous fluids which might stochisticize spin; are there spintronic lipids that benefit humans?

]] (brackets because electron spin is free radicals and sometimes lasts half an hour, nuclear spin is responsive to big magnets)

May 5, 2019

LUMO and HOMO graphics of molecules remind me that electron distributions sometimes look like oblate droplets; if you wanted to pack oblate droplets so they had flat sides like corn, could you place the probability of: a proton quantum tunneling near them; The likely possibility of a proton being near the LUMO/HOMO orbitals might change their shape. Perhaps protons quantum tunnel easier through very thin barriers like monolayer graphene.

Could some chemical reactions go differently if there were (adjacent to proton tunneling probability effects) squared corners on LUMO/HOMO electrons? Square corners on orbitals might cause steep, more discete reactions and bonds, possibly making catalysts more precise or possibly more active or active on different things.

At LUMO of graphene there are kind of ladle shaped orbital graphics; could you make an actual ladle, with a dish of spoon, where the empty part of the spoon has some sort of collecting effect, or a: high electron-density sides of the ladle bowl effect: keeps stuff from spilling out, rather than just a neutral effect; like would an equiattracted positron want to occupy the bowl of the ladle? A proton would be too big and would change all the LUMO blobs. It won’t work, but electron LUMO/HOMO ladles could be imagined as being a physical matter form capable of holding an unreacted positron; so that would be a form of matter you could store antimatter (positrons) in.

Sometime I use the phrase “wide ranging mind” to entertain, that is omit rejecting, thoughts that I do not think will actually work but have some attractive, nifty, fun, gee-whiz thing going on with them. Positron containing ladles is a wide ranging mind, likely wouldn’t work thing.

Does NMN affect plants? As an agricultural technology NMN might cause greater mitocondrial output enhancing growth and possibly the amount of protein in the plants. NMN doubles ATP amount at mice, ups mitochondrial mRNA 50%, and I think plants can be genetically engineered to produce their own NMN

less hygroscopic plants might dry faster. Some proteins like NaPCA and various carbohydrates are hygroscopic. Genetically engineering plants to have less hygroscopic materials could make them faster to dry.



If at the image of orbitals the electron probability goes up at the perimeter of each orbital blob, and the positivity concentrates near the core(s) Then something that does something like tunneling only in the direction of the nucleus instead of electrons at farther from the nucleus could make new devices based on adjusting positive charge. Note this is different than protontronics or proton conductors.

Does the positive core of blobby orbitals have a photoprotonic effect? That is can you send photons, usually thought of as raising electron orbitals into the venter of the blobby orbitals and cause a positivity effect. I think known physics would say no, but what if you have a hydrogen atom next to a nitrogen or noble gas. The proton at the hydrogen, as I think the physics supports, would have a tunneling probability distance thus effecting, measurably effecting, the positivity of the core of the blobby orbital.

Boron and sulfur from polymers. Could you make technological objects from polymeric networks of Boron or sulfur; these would have regularly spaced orderly networks of protons which could be proton-tunneling-radius modified (possibly from being tunneling distance near hydrogen or an alkali metal like potassium or rubidium) while being big enough to have chemical groups on one side, or spaced about the polymeric molecule; so the proton tunnels, the boron gets tweaked (positivity of orbitals changed), and then the cluster of atoms at a distal part of the polymer molecule does something different. If the protons like repelling each other (I think they do) then this could cause higher velocity proton conductors and proton membranes. I think proton membranes are used at some solid-state fuel cells. The idea of making hydrogen atoms at the distal part of the molecule more likely to fly off the tips might be useful at chemistry. I have heard of superacids (pH <1), perhaps the fling off hydrogen higher proton conductor velocity would cause a superbase (pH >14), or be another superacid.

A different, and easily mass producible way of making protoness-enriched molecules could possibly do something to attaching methanes to each other to make liquid hydrocrabons (possibly, sort of, could be, why not?) as the proton tunneling enriched hydrogens at the CH4 vertices might want to fly off when they are near a proton tunneling molecule. After some of the hydrogens fly off the methanes then the methanes connect to make longer alkanes. Reminds me of a catalyst but kind of a protonalyst.

Liquid proton tunneling: when there is a core atom in water it gets a solvation shell or hydration shell around it; It might be possible to make solvation shells out of boron or rubidium linked to a slightly larger than just one atom molecule. These would pile up around the core atom in layers, and the proton tunneling effect would modify the chemistry and characteristics of the core atom. That could make a liquid form of a protonalyst. Liquids with proton tunneling-enhanced solvation shells might be particularly technologizable and affordable. Actually, liquids with enhanced electron tunneling/arrayed concentration from solvation shells could work with electron tunneling as well. Lasers, among other things could energize the tunneling to increase the amount and distance of the tunneling.

Some proton tunneling molecules or polymers might be mass producible; a proton tunneling geometry of polymer monomer could be something like[C-C|B—BC] (thats some carbons with two borns in a row branching off it) that naturally bunches up to have technologizable effects.

I read variable viscosity motor oil rolls up into little balls or not depending on the temperature; a roll making [C-C|B-B-C] like polymer might then have protontronic effects at one temperature but not another, which could have technological utility.

nanoassembler technology: If it is possible to increase the stength of positivity of a proton with proton tunneling then it is possible the electrons are less likely to leave, that reduces reactivity, and something like a better teflon might be the result. Another possibility is making when-it-goes back-to-untunneled-again the molecule goes from less reactive to usual behaviors. Making groups of atoms, or polymers less reactive could cause naotechnological things to be able to more effectively assemble structures from chemicals or atoms A sulfur boron polymer with tunneling-space optimized size of holes or gaps in it could have hydrogen or rubidium drift through them, doing (prompting) the tunneling, and then another area of the boron sulfur polymer could have variously at other shaped holes in the polymer or on eentsy platforms making the chunk of atoms you want, possibly at the eentsy platform or at the custom hole or gap, to be nonreactive. A nanoassembler could use this to dampen the interatom and intermolecule probability distributions, (like cooling, but not actually cooling) causing nanoheaping, atom attaching, and noncrumbling edges at the thing the nanoassembler was building at warmer temperatures. So potentially instead of a liquid nitrogen temperature nanoassembler you could make an STP (standard temperature and pressure) nanoassembler.

Proton tunneling crystals with exteriors that do new things: just like a body centered cubic crystal :.: it is possible that another variety of proton tunneling technology object could have a central atom, like hydrogen or rubidium that has a broadly spanning proton tunneling distance, causing the outer vertice atoms to have heightened protonic strength, that then makes the crystal have protontronic and novel chemical effects on its outside, possibly even adjustable effects if you can move the rubidium around somehow. If it is possible to make a buckminsterfullerene sphere out of boron or sulfur polymer, and then put some rubidium atoms in it you could make a bigger or stronger protontronic structure. Amazingly you might be able to use a laser to wiggle the rubidium atoms at the core of the fullerene which then affects proton tunneling amount (from distance changes) that are externally adjustable.

Liquid proton tunneling: when there is a core atom in water it gets a solvation shell or hydration shell around it, I think I read this can be many lamellar layers ; It might be possible to make solvation shells out of boron or rubidium linked to a slightly larger than just one atom molecule. These would pile up around the core atom in layers, and the proton tunneling effect would modify the chemistry and characteristics of the core atom. That could make a liquid form of a protonalyst. Liquids with proton tunneling-enhanced solvation shells might be particularly technologizable and affordable. Actually, liquids with enhanced electron tunneling/ solvation shell arrayed concentration could work with electron tunneling as well. Lasers, among other things could energize the electron tunneling to increase the amount and distance of the tunneling.

Longevity technology:

NMN benefits laboratory rodents. It ups mitochondrial mRNA production about half again, so other things that heighten mitochondrial mRNA production could also be wellness drugs. SNPs at mRNA generating genes at a cyte might have natural variation which could be researched as to their effect on healthspan and lifespan at humans. wikipedia says “Eighty percent of mitochondrial DNA codes for mitochondrial RNA” so there are lots of genes to look for beneficial SNPS at.

mitochondrial mRNA are described at wikipedia as effecting NADH dehydrogenase and coenzyme Q,both of which I think are published as effecting healthspan. So those are some areas to look for beneficial SNPs at.

At plants, SNPs that effect mitondrial (or also chloroplast) mRNA could heighten agricultural yields, possibly even producing more energy to overcome plant diseases or produce more latitude at the range of growing environments.

Big five personality test could be used by physicians to adjust bedside manner, or have distinct and different bedside manners, with the goal of getting people to take their pills. If 10-30% better pill taking compliance results that would benefit many people globally.

an elaborate approach to custom fizziness: pubmed says, “includes the advent of liquid nanodroplets that are capable of vaporising into gaseous microbubbles upon ultrasonic irradiation” (at the aqueous human body) So perhaps you could make a bevarge with acoustically energizable nanodroplets and then zap the filled container with ultrasound to make eentsy-bubble drinks that might taste different; they could study if putting NMN in fizzy drinks actually increases healthspan as compared with the published nonoptimalities of some fizzy drinks.

Fungus makes longevity chemical: “erinacine A-enriched H. erinaceus mycelia extended the lifespan in both D. melanogaster and SAMP8 (messed up mice) by a maximum of 32% and 23%, respectively” This is the first or second or third product from nature I have heard of that causes greater lifespan; (royal jelly: 30% more at possibly hamsters, curcurmin:maybe, unlocatable reference on whey protein fractions, some%, )

Does erinacine benefit plants, like agricultural plants? They could be genetically engineered to make it.

Do antioxidant rich agricultural plant products stay fresher longer? Commercially, avocados and other plant products that lasted twice as long would be beneficial. They could be bred or genetically engineered. I might have read vitamin E at whole wheat

makes it last longer and stay fresher than bleached flour.

“focus on the delivery aspects of CRISPR/Cas for therapeutic applications in vivo. Safe and effective delivery of the CRISPR/Cas components into the nucleus of affected cells is essential for therapeutic gene editing.” It is likely researcher have already thought about and tested DNA zip codes and organic molecules that facilitate transport to the nucelus. I read melatonin concentrates at the nucleus and saw alist of many nuclear transport facilitating chemicals.

GSK

New antiviral, antibiotic, antifungal and chemotherepuetic drugs: cytes have protein transport channels, both to import, as well as to export (efflux) proteins and chemicals. If you attach some therapeutic molecule, like an antibacterial, antiviral, chemotherapeutic, antifungal, or senolytic, or growth factor, to a protein that has active protein export channels at normal well cytes, but reduced, impaired, or even an absence of some particular protein’s transport channels at virally infected cytes, oncocytes, senescent cytes, or actual bacteria, then the drug would be rapidly exported out of well normal cytes and remain active at unwell cytes. That minimizes harm or unintended drug effects at well normal cytes. It could also reduce milligrams per dose. Keeping some kinds of drugs out of well tissue reduces side effects.

It is possible that besides cytotype and tissue type differences at protein transport channels that things called carriers could be highly specific to particular cytotypes, wikipedia says, “Each carrier protein is designed to recognize only one substance or one group of very similar substances.”

Reducing the spontaneous generation of antibiotic and antiviral drug resistance: Some antibiotic and also antiviral resistance might have come from putting antibiotics or antivirals at an entire 70 Kg of human tissue, and the protein export based concentrator might make it so only the few grams of tissue, that could actually use the antibiotics, are at hundreds of times eentsier areas or volumes precluding a lot of body mass where antibiotic, antiviral, or antifungal resistance can be generated.

Dose amplification from exportation back to circulatory system: Also, the exported drug linked-to-protein from well cyctes seems likely to reach the bloodstream again, making lower dosages possible as well.

At hormones it could cause hormonal contraceptives to only be non-exported at things like uterine tissue, which might have unique protein-export channels, thus reducing the emotional and cognitive, and physiological nonwellness effects of hormonal contraception. micrograms of things like ethinyl estradiol are drugs now, perhaps those micrograms could become nanogram of active ingredient dosages with protein export drug technology.

Along with other antiviral active drugs that localize at a tissue with protein export technology, modified drugs, including drugs that already exist, that treat HIV and herpes could be possible. Side effects could be reduced, and more affordable fewer milligram dosages could be possible.

Protein export drug localization technology: a drug linked to a preferentially exported protein could be a tissue, even a well tissue, localization technology. If the brain has different export channels than the uterus, or the liver has different export channels than the heart or brain, then things like anticholesterol medication, or CYP (and others) enzyme modifying drugs could localize and only be active at the liver.

Cardioimproving drugs: NMN with localization from linkage to an export protein could be concentrated at the heart, reducing heart disease. NMN has already been published as causing elederly rodents to have the muscle performance characteristics of young rodents. That could work at other muscles like the heart as well. I read that 300 mg/kilogram was one studied NMN dose (not sure what they were studying though), that is 21 grams of NMN a day, protein export localization might concentrate that at the heart, perhaps permitting 2.1 gram or 210 milligram (pill sized) heart beneficial drugs.

This also has recreational drug applications, I have heard of a thing called “body high” which is where the drug might be effecting things other than the CNS; I perceive many people would prefer fewer side effects like that at recreational drugs, so if the brain (neurons) have any differences at their protein export channels compared with the rest of the body then it would be possible to avoid activity producing concentrations of drugs at things other than the CNS with protein export technology. Lower dosages could be particularly affordable,and things like a stimulant that does not cause overskinniness, shaking hands, or heightened blood pressure might be possible. LSD might go from a few hundred micrograms per dose to nanograms.

Addressing 2019 AD concerns about opiates; do export protein CNS localized opiates have less functional-dose build up, and possibly less habituating effect if they are only active at the CNS. That would make a low, non-effect-on-the-body, escalationless dose symptom reliever.

Wellness promoting weight reduction drugs: I perceive stimulants were prescribed to make people voluntarily skinnier during the 20th century. Protein export localization might make adipocytes, with particular protein export tranport channels get smaller while keeping the stimulant out of the CNS, reducing or eliminating habituation. Perhaps it is possible to reduce absorption of lipids and carbohydrates at GI tract membranes with a drug, localizing that drug to just the GI tract would reduce or remove side effects. These are voluntary weight reduction drugs that could reduce heart disease, cancer, and diabetes globally, affecting perhaps billions of people.

Export protein localization could possibly differ between things like different types of the neuron cyte. If that is an actual thing, then localization of a drug, like a beneficial psychiatric drug, could occur at just one neuron type (like serotonin neurons but omitting dopamine neurons) reducing side effects, removing lethargy, as well as possibly reducing bodywide side effects compared with the 2019 AD psychiatric drugs that dosed the entire body. If different neuron types have different protein export channels, then stimulating growth at particular kinds of neurons (like dopamine neurons) with protein export localization drugs could be possible with localized growth factors. Bringing nerve growth factor (NGF) or brain derived neurotrophic factor (BDNF) to particular neuron types. Heightened function at dopamine neurons could make living even more rewarding, exciting and pleasant, it could also be a psychiatric therapy like anantidepressant.

Enzymatic linkers produce recpetor-active drugs: A possible enhancement of protein export drug localization technology is the use of enzymatically degradeable linkers between the eentsy molecule drug and the exporter protein. If the non-exported drug, at the localized cyte-type, resides at the cyte for several minutes or hours, then enzymes that already naturally occur at the cytosol would divide the drug from the protein. This also would strongly increase, or even allow receptor attachment of the transported eentsier drug.

Another kind of drug could function as a protein export localization drug amplifier: a drug that increases the activity of protein export channels bodywide (say doubling it) would reduce the residence interval of the localized drug at well or noninvolved cytes. That would create even greater reduction of side effects.

Gene editing technologies like crispr/Cas9 and others could be protein export locationization concentrated at the particular tissue that would benefit from in vivo gene editing while causing much reduced or minimal effects at the other tissues. Gene therapy on the heart, adipose tissue, as well as other tissues and organs is beneficial. Gene therapy export protein localization would make use of protein transport channels at the nuclear membrane, with possibly the cytomembrane being the initial localization concentrator.

Mitochondrial export concentration localizer drugs improve wellness and possibly longevity: mitochodria have membranes, and they have transport channel proteins wikipedia says, “Specific transport proteins that regulate metabolite passage into and out of the mitochondrial matrix” . Bringing something in to mitochondria at a particular kind of cyte or tissue or keeping it out could have a drug effect. Noting longevity and wellness research on mitochondria it might be possible to heighten or lessen the concentration of some drug or chemical (among the chemicals could be peptides and proteins) that causes the mitochondria to be better at making ATP, reproducing themselves (younger people have more mitochondria), or if removing dysfunctional mitochondria would improve cyte, tissue, or body wellness, perhaps unwell mitochondria export some chemicals less than the well mitochondria then concentration from export localization could cause the senolytic-like effect that removes an unwell mitochondria.

I read that there is a mitochondria thing where messed up mitochondria, with shorter mitochondrial genomes are nonfunctional, yet multiply faster than full-genome mitochondria. If these have different drug export channel protein activity, export concentration drugs could be produced, then a mitochondria specific senolytic drug could cause people to just have well fully functional mitochondria. That could increase cyte, tissue and body wellness and possibly longevity. Mitochondria localized export technology could be possible.

Is there anything, which if preferentially exported from the nucleus, through the nuclear membrane, causes greater longevity as well as, or, greater wellness? Upping activity of, or finding SNPs at protein or nuclear membrane chemical export channel genes could then be longevity wellness genes.

A particular export drug localization drug form: looking at wikipedia a possible actual protein export drug localization technology, wikipedia https://en.wikipedia.org/wiki/Nuclear_export_signal says, “ A nuclear export signal (NES) is a short target peptide containing 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear porecomplex using nuclear transport.” So attach the 4 amino acid peptide to the drug you want to keep out of the nucleus of some (physiologically well) localized cytes or tissues. Screen a big library of 4-10 peptide variants on the NES peptide, and find out if some have unique cyte or tissue localization; attach the 4 amino acid peptide to the actual drug with an enzymatically degradable linker.

Noting though, that 4 amino acids does not contain that many atoms, and that noting molecular modelling software exists, it is possible that an organic molecule of comparatively few AMU could be developed to replace the 4 peptide exporter protein. This has the advantage of oral dosing, which might (likely would) effect eating an oral peptide. Then link that new few-AMU organic molecule to the actual drug, possibly with an enzymatically degradeablelinker, to produce the protein export effect localized drug.

Wikipedia also says, “Several ways of regulating NES-dependent export have been reported. These include masking/unmasking of NESs, phosphorylation and even disulfide bond formation as a result of oxidation” so those might be areas that have technology value

a gentle to the body drug, that could be antibacterial and senolytic and chemotherapeutic is some chemical that gloms magnesium and zinc. These are used at the ATP generating cycle, and without them, ATP production at the cyte would cease, terminating the cyte. That could function at antivirals, senolytics, chemotherapeutics; Some similar thing, perhaps with different metals, might work at bacteria. I perceive that there could be a protein or few-AMU organic chemical that chelates (gloms) a specific metal ion, terminating the cyte where it builds up. Preferential export of that protein or few-AMU organic chemical would make it so well cytes kept their ATP making metal ions while the unwell cytes with the different export protein activity would get zapped.

Some chemical that gloms Cu, magnesium and zinc could be a universal cyte terminator for anything that uses ATP. This is kind of like the high affinity cyanide has for metal, so basically a protein or peptide version of cyanide that is fully exported from well cytes could terminate perhaps any living cyte or tissue, including bacteria and fungi.

Wikipedia also says, “Several ways of regulating NES-dependent export have been reported. These include masking/unmasking of NESs, phosphorylation and even disulfide bond formation as a result of oxidation” so those might be areas that have technology value.

A possible actual exterior cytomembrane export localization drug: Noting that a 4 amino acid peptide works at the nuclear membrane it is possible there is also a short peptide that works on the exterior cytomembrane. Again, make a bunch of variants at a library and screen them; find an orally functional few-AMU organic molecule that does the same thing. Also, noting: Wikipedia also says, “Several ways of regulating NES-dependent export have been reported. These include masking/unmasking of NESs, phosphorylation and even disulfide bond formation as a result of oxidation” so those might be areas that have technology value.“ It could be that doing those kinds of things also tunes the localization from purposefully constructed export drugs and technologies that work at protein channels, as a technology that enhances the form of the organic molecule or polypeptide that does the exporting.

There is a list of different NES peptides, wikipedia says, “The binding of NES to the export receptor of a protein gives the universal export function of NES an individually specified activation of export to each protein. Studies of specified NES amino acid sequences for particular proteins show the possibility of blocking the NES activation of one protein with an inhibitor for that amino acid sequence while other proteins of the same nucleus remain unaffected.[5]

NESbase[edit] NESbase is a database of proteins with experimentally verified leucine-rich nuclear export signals (NES). “ That provides more material to make screenable libraries and also few-AMU organic chemical functionalikes from.

a drug that could be attached to the export facilitating chemical or peptide: a gentle to the body drug, that could be antibacterial and senolytic and chemotherapeutic is some chemical that gloms magnesium and zinc. These are used at the ATP generating cycle, and without them, ATP production at the cyte would cease, terminating the cyte. That could function at antivirals, senolytics, chemotherapeutics; Some similar thing, perhaps with different metals, might work at bacteria.

I perceive that there could be a protein or few-AMU organic chemical that chelates (gloms) a specific metal ion, terminating the cyte where it builds up. Preferential export of that protein or few-AMU organic chemical would make it so well cytes kept their ATP making metal ions while the unwell cytes with the different export protein activity would get zapped.

Some chemical that gloms Cu, magnesium and zinc could be a universal cyte terminator for anything that uses ATP. This is kind of like the high affinity cyanide has for metal, so basically a protein or peptide version of cyanide that is fully exported from well cytes could terminate perhaps any living cyte or tissue, including bacteria and fungi. As primitive as it sounds, HCN, or just CN attached to the tip of a peptide, at a weak link, might be a CN metal ion glomming peptide drug exported immediately out of well cytes.

Another thing which is notably different than protein transport channels is exportation of materials from the cytosol using vesicles. Wikipedia says of things the cyte makes, (like neurotransmitters) that get sent out of the cyte to the intracytoplasmic space, “Membrane proteins with functional areas on the cytosolic side of both the vesicle and cell membrane make sure the vesicle associates with the membrane. The vesicle membrane fuses with the cell membrane and so the protein leaves the cell. Some vesicles don't fuse immediately and await a signal before starting the fusing.” So it says that vesicles do not just fuse with the cytomembrane and put stuff into the space between cytes, there is actually another chemical or protein that says when, and possibly how much, to do it. Drugs, genetic engineering or gene therapy that effect the proteins or chemicals that say when or how much vesicle based export happens could have numerous medical uses; psychiatric drugs that heighten things like dopamine vesicle release (or other neurotransmitters) are likely to have effects on perception, illness, wellness, and also could be recreational drugs. Also regarding wellness healthspan and longevity I read that senolytics, which cause greater wellness, and I think, longevity terminate cytes that export a bunch of things that make well cytes less well. Some of those things might be interleukins (IL-number), so a drug that changes the amount of vescles exported could have the benefits of a senolytic (less exported messes-up-things chemicals like (il-number)) while using the different mechanism of vesicle activity.

It is even possible, that at an entire human body increasing or decreasing vesicle fusion and export of things everywhere could have a beneficial effect. Kind of reminiscent of caloric restriction or methylation/acetylation has entire-system bulk effects. Even a nonlocalized drug that changes the amount of vesicles exported could be a wellness drug. Custom vesicle content export and localization would be more optimal though. More vesicles might run things faster, fewer vesicles might run things slower.

ATP attachment site drugs and gene therapy: Where and how do phosphate groups from ATP actually change the energy, or electron HOMO blobby shape of a protein to make it do something? I do not know, wikipedia says of a different thing, “Nuclear export first begins with the binding of Ran-GTP (a G-protein) to exportin. This causes a shape change in exportin, increasing its affinity for the export cargo” so since GTP is guanosine triphosphate, the actual polyphosphate thing (reminds me of ATP) attaches to the actual protein, the protein’s HOMO changes, then the protein changes shape; perhaps ATP actually attaches the protein it energizes, changing the protein’s shape. So that brings up a possibly technology: a protein might have specific ATP attachment areas on it. does changing the number or location of the ATP attachment sites cause more, faster, or different, protein behavior.

Could gene therapy and also genetic engineering modify the number of ATP attachment points at a protein, so like if “tau” is an alzheimers protein, gene therapy that removes ATP attachment sites from it (its genes) would cause it to bunch up in a different harmless shape, or possibly move slower, or be less easily produced; noting the contested 2019 AD idea that tau is linked to alzheimers (there are studies that say it is a defense against alzheimers though); If a different protein effects alzheimers then gene therapy on its ATP attachment locations could minimize the amount, and reduce or modify the activity of that protein. Changing the location and quantity of ATP attachment sites could treat many illnesses, there is also the possibility that making more ATP attachment sites, or putting them in new places, could heighten wellness, capability and longevity.

Another ATP technology is: is there anything better than ATP?

some adenosine-like-thing triphosphate (screen a library of a bunch of different “aminosugar” triphosphates on tissue culture cyte wellness and longevity to see if any other triphosphate actually works better than ATP; modifying the mitochondrial genome to make the new aminosugar-triphosphate could provide better energetics (of some sort) to the cyte, tissue, and organism). It is possible something eentsier like a glycine triphosphate is possible; that would have faster diffusion thus be more available everywhere, possibly heightening the refreshment of utilized material and replenshing reserves quickly.

Wikipedia says, “ATP synthase” is the enzyme/protein that actually makes the ATP,I thought modifying the genes of that enzyme could produce a different, better, triphosphate, but I think it just truns ADP to ATP. I do not know what builds the AMP or ADP base.

Glycine triphosphate being less AMU would diffuse faster, perhaps causing the cyte, tissue, and organism, to have more continually refreshed cytochemical capability.

Could the isotope effect from lighter than average phosphorus atoms cause more ATPness activity; it would be nifty if there were a stable light phosphorous, but as a science thing, even a neutron reduced radioactive version could be measured as to its effect; that could provide an indicator as to whether

flexible ATP, ATP with just one atom different to make the HOMO blobs more likely to launch a phosphate, or perhaps more hesitant to launch a phosphate, could make ATP energization of proteins better.

flexible ATP: (or some other amino TP) might be able to rotate easily around an atom-atom link causing more rapid topological fit with the protein it was energizing; similarly a “hinged” version of ATP might have the greater flexibility to attach and phosphate-group energize the protein it attaches to more rapidly. More rapid attach and phosphate energize, as well as higher velocity unattaching of the new aminodiphosphate molecule could cause more energy actions per microsecond from fitting faster, and deattaching faster, permitting more event per amount of interval.

ATP with just one atom different to make the HOMO blobs more likely to launch a phosphate, or perhaps more hesitant to launch a phosphate: a molecular model of ATP might suggest a way to change one atom to make the molecule more polar, or facilitate the popping off of the phosphates, or possibly make the adenosine part better at nestling into some cradle-like attaching structure on each protein that ATP powers. Then genetically engineer mitochondrial genome to make the better than ATP version.

Entertainment: so if ATP is produced at mitochondria, what do the ATP transport channels at the mitochondrial membrane run off of? It could be a different triphosphate like GTP, some other thing, or even ATP, just that the ATP might thoroughly coat the ATP transport molecule proteins so the other can all travel through them. Wikipedia seems to have a tropism towards the idea it is some other thing.

Peptides are easier to make with modified genetics than other things, and can also be externally produced and used as drugs. Wikipedia says, “A published human mitochondrial DNA sequence revealed 16,569 base pairs encoding 37 genes: 22 tRNA, 2 rRNA, and 13 peptide genes.[51] The 13 mitochondrial peptides in humans are integrated into the inner mitochondrial membrane” What happens when you make more of those peptides, variants on those peptides, or even recptor occupying but nonactive versions of those peptides? These could be new beneficial drugs that are particularly makeable, testable, and possibly dosable. That there are fewer than 14 peptides specified at the mitochondrial genome suggests that putting each of those peptides at human cyte tissue culture to see if more of them, or some variation on them, is beneficial could generate new beneficial drugs, as well as possibly some unusually easy gene therapy (example: liver cytes are 99% transfected with a new gene, at the first decade of the 21st century); gene therapy on the liver to produce higher circulating levels of one of the mitochondrial peptides might reach the actual mitochondria, having the beneficial drug effect; that is mitochondrial heightened effectiveness without modifying every cyte at the body; as to easy dosing, it is not that easy, but it might be snortable; another version is that I have read about orally bioavailable peptides, one was linked to salmon calcitonin so you could take a 100mg if that was beneficial.

Mitochondrial chemistry might support a new nootropic: wikipedia says, “In neurons, concomitant increases in cytosolic and mitochondrial calcium act to synchronize neuronal activity with mitochondrial energy metabolism” that sounds like neuron activity causes mitochondria to make more ATP via a calcium way of communicating, so certain kinds of neuron activity could actually heighten protein interaction amount and possibly velocity and cytoprocesses, at least at those neurons. There could possibly be a drug that makes your brain be a certain way, possibly including a tropism towards some version that is a beneficial thinking style, that heightens mitochondrial activity and makes more ATP for the neurons to run and repair themselves.

From a localization perspective, if some peptide or protein linked to detachable calcium can reach the mitochondria (possibly with export or import concentration dynamics at particular kinds of neurons like dopamine neurons) then the neurons might become more active from the calcium-mitochondria-ATP communictions. Also I may have read that the formation of long term memory comes from protein synthesis at neurons; more ATP could increase the memory storing capacity at the human from making proteins more rapidly synthesized, as well as possibly a producing a pool of optimal proteins that require higher sustained energy to make, that are better at making rememberables. Also brief learning events, imaginably less than a minute, might be recorded/protein memorized with higher fidelity and not missed or forgotten, because there is enough ATP and calcium communication to record things before they are obscured with background stochastics. A calcium peptide or protein that passes through or concentrates at mitochondria could be a nootropic, a memory drug, as well as a possible psychiatric drug basis.

electret proteins or possibly peptides as cytosurface things that can change cytochemistry: wikipedia says, “Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell. With respect to the exterior of the cell, typical values of membrane potential, normally given in millivolts, range from –40 mV to –80 mV.” So an electret an electrical engineer thinks of might be a polymer with all the charges aligned so that a face of it is all one charge. If you make an electret amino acid polymer, peptide or protein, can you cause a lasting electrical charge effect at the cytosurface? What would it do? Well, positive or negative electret biopolymers could have different drug effects; electret polymers at the cytosol could have other drug effects; mitochondrial area electrets, either as membrane passing peptide or protein drugs or engineered into the mitochondrial genome as produced proteins or peptides with organized surface charge, could, I am thinking about thinking, affect chemical processes from dipole-dipole interactions. “induced dipole-charge interactions between the negative charge in the electret's polymer layer”.

So, that could be a thing where making an electret protein would change the reactivity, spacing, and membrane transport of other biochemicals like proteins and peptides. Also, the dielectric arcing voltage at air is much larger than “–40 mV to –80 mV” (at cytomembranes) so an electret protein or peptide at the cytosurface could possibly dilate or undilate a tube, channel or effect a protein’s shape, even thought the electrets current is eentsy. You can get a loop of hair (kind of like aprotein polymer) to straighten next to a balloon with a charged surface so it could work. Unless there is a voltage arc the biochemical polymers that make up the hair, at least for some biochemicals, would have dipole-dipole interactions, which might or might not be able to change actual atom-linked-to-atom chemical compositions.

Biologically produced electrets that modify cytoprocesses to favor various reactions and proteins: There could be a way to: attract a sandwich that reacts; electrets can pull microparticulates out of the air; if you have a 700 volt electret and a 1100 volt electret and a 1700 volt electret and a 1400 volt electret arranged (tesselated) at a 2d array, (made out of protein, at the cyte, or possibly as an externally dosed drug) they would each attract different sizes and actually different atom configurations of molecules like different proteins; so perhaps you would get an array with lots of ATP next to some ribosomes, an amino acid nitrogen donor, next to a chemical like almost-complete dopamine. That electret array, made of biopolymers like protein would basically be custom size and protein-made up of charged amino acids dust(micro particulate) collector, stacking the reactables next to each other at a big array, then they would happen to react from their own chemical energy favored dynamics. (I saw mentioned at a paper that 5 nanometer electret polymer threads were produced, and I read some biochemical thing was size 9 nanometers.) The ribosomes might get more ATP, because they were right next to it, (the ribosomes use the ATP to do protein shape changes and movements; possibly (or possibly not) attaching the phosphates to the ribosome to power the ribosomes protein activities; the ATP runs the ribosome); the ribosome would be getting much more ATP than they would have received from cytosol diffusion of ATP only. That causes them to make more protein from having the ribosomes have more energy, or possibly have higher velocity of protein making.

A a-few-atom-AMU dopamine pre-molecule might react with the amino acid nitrogen donor next to it (like a peptide or protein) that the electret sorted for it, which then makes an actual dopamine molecule. At an array of 5nm or eentsier the predopamine next to the nitrogen donor could have much larger than 1000 times 1000 spatial arrays, so that is a million dopamine molecules just from the electret presorting and arranging the reactants to be near each other.

Aqueous environments and electrets; electret biopolymers like arrays of charged proteins at lipid rafts could heighten the spatial reach and capability of electrets as compared with solvation shells around an electret at an aqueous environment. I perceive that an electret at an aqueous fluid might form something like lamellar solvatation shells on its upper electret surface, and that things like ATP molecules that drift through the solvation shell would then glom to the electret.

There is a possible modifier to the solvation shell electret environment: negative contact angle water repelling geometries are published, making these superhydrophobic negative contact angle shapes, at an array, out of proteins might still be functional even at eentsy portions of a cyte cytosizes. Another possibility is bubbles; some cytochemistry that produces bubbles of something like O2 would cause the electret at the bubble to have different Thin films and that might have some effect.

At a lipid raft, lipid surrounded protein bioelectrets could glom things further away and the higher mass of the lipids might reduce stochastic (diffusing) motions, so any biochemical like a protein, that is hydrophobic, thus more lipid soluble, with various surface charges, is likely to be particularly glommable at a lipid raft surrounded electret. I have read that there are lipophilic proteins and, I think, multi protein quaternery structures (like a group of proteins making a big shape that might (sometimes) do some motional things). electrets and quaternary protein structures might do things together, what I do not know. perhaps something like a bunch of AMU dehydrogenase is array-arranged to be next to things that could benefit from dehydrogenation.

Also, from near neighbor diffusion at the surface of the patterned electret array perhaps having a few beta sheets next to each other will tend to cause some predictable, valued, autoassembly. Possibly.

Electrets at lipid rafts could arrange these at spatial arrays for heightened reactivity, neighbor optimization, and also at preferred combinations; there could even be the possibility of sequential reactions from having cascadeable reactables accumulating on the array surface of the biopolymer (like protein) electret: a ribosome behavior adjusting protein accumulating area next to the ribosome accumulating area, next to the ATP accumulating area; they feed into each other. Pretty predictable, but if you have a linked sequential reaction at 2d space you can make a loop, and with a loop you can make a computer.

The electret biopolymer array would continually glom and sort new reactants as they drifted around the cytoplasm, or at a lipid raft, hydrophobic molecules, like hydrophobic proteins, that drifted from the aqeous cytoplasm to populate the lipid environement. That continual material refreshing at an array keeps the array favored product being produced as well as the sequential reactables (or protein shape changeables) automata-like thing (computerish) regenerated with fresh reactables.

A lipid raft version of biopolymer electrets that generates orders of magnitude larger chemical changes from a slight electret biopolymer effect: I read there are possibly lamellar stacks of lipids at the cytomembrane, these are called lipid rafts. If these are made as electret versions of lipid rafts or just have locations at the lipid raft for numerous electret proteins to be at, then you get a portion of the exterior, or interior, of the cyte that preferentially gloms particular charges and sizes of proteins or peptides from the intracyte fluid or at the cyte’s cytosol.

Another function of electret rrays made from biopolymers like proteins is lysosomal activity. What if you get all the tau or lipofuscin glommed and its array neighbor is a peptide or protein tag that says “put what this is attached to at a lysosome”;the two being neighbors attach more often, and the tau or lipofuscin gets removed.

So it is possible that rather than an electret you could use a tree and a bunch of branches variation on an antibody or aptamer (like a dendritic antibody) to glom valuable-to-react molecules so they are neighbors and then near neighbor drift and reaction causes more actual protein shape change and chemistry than they would do from a diffusion at the cytoplasm system.

Data communications and transfer lipid raft; the electret lipid raft has electrets at an array that glom a kind of survey of cytochemical (like proteins) quantity at areas of charge and size, then the outer side (intracyte fluid) of the lipid raft responds (protein linkages) to the cytosol side’s array of measuring electrets, producing an external to the site more readable database of the cyte’s protein, peptide, lipid, other chemical quantities and concentrations.

Another use for a more macroscopic lipid raft with electrets that does size and charge sorting of things is a sensor at a robot or other technology object. A lipid raft electret could be a nose like chemosensor.

So, an electret array (3d also could be possible) made of biopolymers could arrange neighbors to beneficially react with each other to produce beneficial products.

Perhaps there could be lipid membrane based electrets as well; myelin; lipid rafts on cytomembranes; I read there are possibly lamellar stacks of lipids at the cytomembrane, these are called lipid rafts; if these are made as electret versions, or have locations for numerous electret proteins to populated at, then you get a portion of the exterior, or interior, of the cyte that preferentially gloms particular charges and sizes of proteins or peptides from the intracye fluid or at the cyte’s cytosol.

A system with a high voltage (near air arcing) minimal current thing like an electret, next to a 40-80 mV biochemical fluid thing with much larger amounts of current (electron quantity), where to produce new and beneficial effects changing what the big current source does (flows are like) based on the eentsy current high voltage (I perceive electrets are thousands of volts) reminds me of transistors; so a technology that would make this more effective would be a way to make protein transistors. One possibility is cascading neighbors that the electret attracts, even possibly, although it seems kind of predictable, a CCD or photomultiplier tube (2019 AD) like effect. Also mentioned is that if you have an autorefilling-from-diffusion at the cytoplasm spatial array you can arrange the array elements to attract things that interact, or react, next to and with each other, and then you can use the spatial thing to make actual lanes and loops like a computer.

biopolymer electret arrays, possibly with superhydrophobic geometries (unless the human making this likes electret arrays with solvation shells and aqueous diffusion of glommables) that do things at each cyte and that then effects tissues and the entire human, reallocate ATP to where it most contributes to human longevity wellness and happiness. Like actually, say the research says heat shock proteins and histones make mice and people live longer and be weller. You have the electret

Topical adenosine as a youthfulness beauty drug: wikipedia says, “Topical treatment of adenosine to foot wounds in diabetes mellitus has been shown in lab animals to drastically increase tissue repair and reconstruction.” so topical adenosine could prevent: scarring, some sort of skin disruption thing from UV at sunshine, oozy inflamed skin cumulative flexibility and cosmetic appearance changes, or possibly (I kind of have a feeling that tissue drying and cross-linking might have some similarities to nonhealed skin), and also the 2019 AD skin effects of chronological progression.

I read about how some electrets are able to transfer their charge based on physical contact; that reminds me of nanotechnology because some versions of nanotechnology proceed from something kind of like mechanical engineering as compared with chemistry; so if you can transfer charge with contact, then a nanoassembler that “inks up” a nanopart by placing it on an electret surface, then positions it again on to another nanopart, could get the two to stick together from complementary electric charges. Note this is different than electron outersurfacecoatings like “static” electricity, the paper says it is ion transfer (atoms phycially move) So basically (kind of) the nanoassembler has the ability to coat parts with glue to keep them together, and to reduce stochastic unintegration. Perhaps it is also possible to make a (technology word:) nanotechnology jig to attach things to it for movement between areas. A thing https://pubs.acs.org/doi/10.1021/ja067301e says about the electrets that do this, “This paper describes the fabrication and characterization of ionic electretsmaterials that bear a long-lived electrostatic charge because of an imbalance between the number of cationic and anionic charges in the material. Crosslinked polystyrene microspheres that contain covalently bound ions and mobile counterions transfer some of their mobile ions in air, in the absence of bulk liquid, to another material upon contact. According to the ion-transfer model of contact electrification, this selective transfer of mobile ions yields microspheres that have a net electrostatic charge.” Also, it is, to my perception, a strong effect; the article to might be saying that if it were any more powerful there could be an electric arc through the air, “The charge on a microsphere is proportional to its surface area (ca. 1 elementary charge per 2000 nm2) and close to the theoretical limit imposed by the dielectric breakdown of air. The charge density in an atmosphere of SF6 is more than twice that in an atmosphere of N2. These observations suggest that the charge density of these ionic electret microspheres is limited by the dielectric breakdown of the surrounding gas”, I do not know, but that sounds like the energetics of the system have a much higher voltage than any two dissimilar metals at electrochemistry, so just perhaps it could outdo chemical effects that might cause a nanotechnology assemblage to react chemically rather than be configured to nanomachines.

Longevity technology

Do enzymes make or regenerate NMN at the body? Genes for these could have SNPs that are high wellness phenotypes, gene therapy could be a wellness drug. Although NMN only made mice live 5% longer further study might find a longevity effect, notably from cardiowellnes and perhaps youthful liver function at removing xenobiotics and reducing cancer,

Are there naturally occuring body produced chemicals that contributed to more than half of 20th century cancers? (with the idea that xenobiotics, stress, possibly EM, sedentariness and food might have caused much of the rest) SNPs about these body occuring carcinogenic chemicals could be anti-cancer gene variations that people could optimize with genetic engineering and gene therapy. Insulin and growth factor genetics are possibilities, as is possibly sex hormone levels and SHBG (plasma fraction that gloms steroids); I think there are published systems approaches as well, like mRNA math distribution change with physiological challenges, epigenenetics, and mitochondrial number change.

Longevity chemical: It is my perception that some cytes have less than a dozen mitochondria, and other sites might have near 400; If you do gene therapy or modify the human genome to have mRNA for proteins that would otherwise be affected as to their amount from having fewer mitochondria per cyte from chronological duration effects produced at those cytes (and tissues) that have upper third of mitochondrial number quantity does more of the previously diminishing protein get produced, thus benefitting the body and causing youthful levels of protein to exist? Some proteins travel from cyte to cyte as neighbors as well as circulate at the circulatory system, the proteins that travel outside the cyte could be especially engineering effective at sharing benefit from the gene-therapied, many-mitochondiad cytes and tissues.

Genetic engineering biochemicals to be mRNA coded or produced at the ADP makes ATP cycle, which processes 90 lbs of ADP every 24 hours looks like higher volume production.

I think the ethics and engineering of making humanly intended (mind) physical or possibly neural activation alone, actions modify genetic expression and thus phenotype support the beneficial use of this technology. Prior to 2019 AD and I think anytime, It would have been nice and beneficial, and not that much effort if people had the ability to modify the output of their genes and voluntarily modify their phenotype from simple purposed actions. Things like skipping a day of food, drinking a gallon of water, or recieving a two hour pleasant massage could all be adressable gene switches to turn on beneficial effects while being just slightly unusual enough to omit unintentional activation. Would you like your beautiful personally appreciated hair to grow twice as fast? Get a two hour massage once every 6 months. Getting a massage, even massage at a specific body part to get a specific gene activating phenotypic effect is a possible way to adjust pehnotype voluntarily at the individual, without medical, chemical, social, or fiscally-linked activity based actions. You can give yourself a massage, become more socially fluent and have more fun. It is highly valuable to have previously heightened cognitive ability at all persons, people, humans to higher amount, I think genetically engineering persons, humans, that is people at the germline and thus phenotype to be three, four, or five times more intelligent than I am, with the persons, people, that is humans having the ability to make their beings more intelligent from that is beneficial and more optimal.

Another possibility is a minimal amount of exercise, possibly with different muscles switching on or off different genes, like if you prefer more responsive dopamine receptors (more fun!) then walk more. This increases the amount of mitochondria, the protein production of the cytes, and possibly the actual number of muscle cytes as well. Technologically among the things are the gene therapy or modified human genome concentrating the production of biochemicals or also proteins that can circulate, or possibly things like neuron-localized nerve growth factors produced at muscle that then increase growth of doapmine neurons. (the thighs, but only the thighs produce a chemical, that when it circulates increases a growth factor like NGF or BDNF at just dopamine neurons) So walking exercises the thighs, and that produces chemicals that cause the brain’s phenotype to improve to have more dopamine responsiveness and more dopamine. If you prefer less dopamine you could do sit-ups. wlaking is easier than sit-ups, to my perception, so people with this intentionally changeable phenotype genetic form might sort of have an automatic happiness fun physiological tenedency,although just genetically engineering people and germlines to be much happier is beneficial and I support Dave Pearce’ hedonistic Imperative.

As an early 21st century longevity technology, producing more mitochondria, whether with chemicals, gene therapy, germline modification, or exercise, might increase the production of other proteins at the cytes from simply making more mitochondria, which makes more ATP available, at all of the proteins coded at the genome. It is imaginable that just light exercise could up cytolocalized biochemicals and circulating biochemicals 20%. During 2019 AD many people found it easy and enjoyable to actually double the mass of some of their muscles, so that might double the amount of a preferred protein or circulating biochemical. Different genome product directors and switches than exercise are likely to be more beneficial and popular than exercise. Drinking a gallon of water all at once, or getting a pleasurable massage once every six months is much less effort to do, and sustain, as a goal-seeking activity at consciousness than sustained exercise.

As a technology it is possible to do gene therapy on a just one body part, and then have growth of that part make more of the phenotypic chemical like a protein or other biochemical or chemical, to produce local effects (GFP output changes with tissue use which I think is published as increasing transcription at the utilized tissue, exercising should therefore make GFP at muscle tissue increase, and instead of GFP it could be different physiologically beneficial protein or other biochemical)

Surpisingly muscle, which coalesces to multinucleus cytes and can have its number of mitochondria heighten just with use, could be a location to produce beneficial proteins with go-everywhere-activity, although other gene directors and activators are likely to be more avidly used, like massage, skipping or eating an anomalous amount of food, or getting a massage, even massage at a specific body part to get a specific phenotypic effect.

(I may have read that 80 year olds might have only 40% of the mitochondrial numbers as 20 somethings); this affects how much energy there is to produce new proteins, how much is produced, and possibly if they are produced at all. I think I also read that the number of mitochondria, which goes with the amount of )

I read ATP might travel on actin filaments, somehow, even though ATP is an eentsy molecule. It is plausible that tubulin also effects ATP transport. If actin or also tubulin transport of ATP is actual, then drugs or genes that modify the ability of actin to transport ATP could be wellness drugs and possibly longevity drugs, or even treatment of illness drugs. Also as a possible wellness longevity drug or genetics is the effects on the actual location arrangement and network of the actin or also tubulin that transports the ATP. Multilane highways or dendritic branches? Concentrated depots and paths, or partially populated walkways? There is a possibility that a computer science approach to optimizing the mathematical network form of actin or also tubulin transport of ATP could benefit humans at the cytological level with drugs or genes that reprogram actin or also tubulin based transport to optimize human well being. I perceive I have heard about research on what actin and tubulin goes where during meiosis and why, so perhaps some of those techniques and research could benefit the technologization of actin and tubulin engineering for wellness and longevity.

I read about some chemical in Scientific american that is sometimes described as “exercise in a pill”; exercise increases the number of mitochondria at muscles, perhaps “exercise in a pill” at the circulatory system reaches more cyte types, even neurons and also tissue types and increases the number of mitochondria at them, increasing wellnes and possibly heightening lifespan from removing nonoptimal effects at linked dynamic systems.

Another thing that increases the number of mitochondria is branched chain amino acids, “Branched-chain amino acid (BCAA) supplementation increased mitochondrial biogenesis in skeletal muscle [4]. BCAAs are 3 of the 9 essential amino acids required for humans.” [not made at humans though]

Genetically engineering food crops to make BCAAs could have quantitative measurable wellness effects, and just possibly from more mitochondria, beneficial longevity effects. Soybeans, wheat, legumes all contribute to protein sources during 2019 AD, and these nd other plants could be engineered to make BCAA.

Developing a plant-based milk that tastes more delicious to the majority of humans than dairy milk would be a valuable ethical vegetarian technology. Among Europeans and Americans milk, which could be technologically improved to be better-than-dairy-milk plant based milk, provides much protein to many people. Genetically engineering plant based milk to have BCAA, possibly BCAA optimized to generate more mitochnodria is beneficial.

Technology that enhances vegetarian milk: Are there any good tasting surfactants? that would make the little globs customizable in size for flavor adjustment (improvement).

Can you put veggie milkpowder as a thin layer through an embosser with the resolution, or higher, of a holographic decalmaker? Microfeatures at blobs eentsier than a wave of light could then be used to technologically improve the milk product as solvated globs; Also I have read about superhydrophilic and superhydrophobic surfaces, teeny spires (hydrophobic) or angled sided spaces that look like ingots (hydrophilic), it could be that embossing vegetarian milk powder to make hydrophilic or hydrophobic features could enhance flavor. Also there is customizing globs to physical tongue receptor size for an optimal fit. Uncomplex embossing of a powder could be ultra-fiscally favored. Ihave seen candies made of sugar that have a hologram embossed on them, so lightwave feature size at carbohydrates is a technology that has existed since the 20th century.

.5B GSK:

I perceive that GSK may have (or may not) have links to companies like nestle; could cocoa, and possibly thus chocolate, be wavelength of light feature size embossed to enhance flavor?

Are there any naturally occuring amino acids or peptides that activate the taste receptors that activate when milk tastes good; this is completely different than MSG (monosodium glutamate) in milk, but the technology of an amino acid or eentsy peptide that enhances the flavor of veggie milk could be possible.

school lunch veggie milk

It seems like things like vegetarian nut or soy milk could be cheaper to produce than dairy milk. I think it is possible to develop the vegetrarian milk flavor until it is preferred over diry milk among most people. It is possible that more people, throughout their lives, would like an utilize vegetarian milks if they received them at school lunches.

It might even be possible to use vegetarian milk to cause people to be weller in different ways. If the serving size of vegetarian milk is 10 Oz, as compared with the previous 8 Oz at dairy milk at identical calories, then people might drink more fluid at school lunch. Drinking more fluid at school lunch causes a population effect of eating fewer calories at the rest of the food. Then noting that at 2019 AD, research supported that vegetarians had less heart disease, cancer, diabetes, and weighed less with a better BMI than the rest of the population, the school administrators could say, “there’s nothing wrong with our food, but it’s awesome students are drinking nut/soy/oat milk and eating less of the other items and more vegetable sorced food instead” So the people at school get more ounces of milk, they are, as a population at least slightly wellness heightened, and the school district spends less on the milk. That all combines to support vegetarian milks at school lunches.

MWI, that is Many Worlds Interpretation of physics: thinking of ways to cause a larger number of MWI universes to be generated from something going right, that a person, that is a human likes: The amount of quantum states produced from a proton (protons have their own quantum effects, among them tunneling) is, I think, larger than that of af a neutron

Note: about protons or neutrons having different numbers of quantum states, and that they each generate quantum state changes at different amount for each unit of chronological moments: I think protons have more quantum states as an area with t as a dimension, although it could be otherwise. Thinking about the quantum effects of neutrons ( I am thinking about neutrons taht are a part of atoms): if a neutron (just one as part of an entire atom) is changing a chemical rection in a flask with the isotope effect it may or may not be having a quantum mechanical effect at a multitrillion atoms simultaneously at chemical system that is some chemicals in some water in a flask.

That the isotope effect of one (part of an atom thus nondecaying) neutron, which should have at least some analog effect on all the actual atoms at the chemical sample if analog, functions at a distance (at an aqueous chemical system it could be nm, Cm or Km); the analog possibility comes from what seems like an analog nature of things like circles and various math of topology that seems like they could be having an effect at a 3d chemical system; The thing is that I perceive a physicist might say, “even though you can observe it into a circle, or a sphere, or even that the sides of the container are changing (however minutely) to produce either space or time analog-like things, it is all describeable with a quantum wave function and quantum equation, so prior to 2019 AD observations that support quantum theory support that it is actually just a quantized system, the neutrons are not having an analog effect when one neutron produces an isotope effect on an entire flask with quadrillions of atoms at a flask of aqueous chemicals”.

That a neutron being turned into a proton causes the number of quantum states possible, as well as generateable, per unit of chonologically measured moments, suggests that making neutrons into protons could be a technologizable way to purposefully make a larger number of MWI universes when a sentience, like a person, that is a human likes what is going on.

When a neutron is turned into a proton, that proton often attracts an electron, (does the casimir effect preclude the possibility of naked protons staying solitary?) which then do electron and photon quantum things, numerous of which are described at peer reviewed published material as being quantum effect actions, each quantum event with an MWI branch universe 92019 AD theory); converting a neutron to a proton then causes a much larger number of MWI branches to be generated, for the theoretical duration of the universe. Although I am not yet educated sufficiently able to use aleph numbers to do calculations, if the universe happens to be chronologiclly nonfinite then the number of MWI universes generated from one neutron being converted to one proton is a nonfinite number, and further, that nonfinite number has many many MWI branches (I perceive I have read that human researchers might have different scientifically supported ideas about whether MWI branches are finite or nonfinite in quantity).

Thinking about a new proton coming from a neutron: a new proton at a chronologically nonterminating universe would have a nonfinite number of MWI branches though; or perhaps could, I read about people who think cooling all atoms to their quantum ground state is a spontaneous actual process at the universe; although MWI suggests that things like time crystals and the delayed quantum choice eraser could effect quantum-capability of atoms retrocausally or cyclically at some amount of the MWI universes; I have heard of these things, so the MWI universe I am in might be entropically nonmonolithic

A technology that utilizes the difference between a proton and a neutron to cause more MWI branches where a human things things are pleasantly going the way they like. I like Serina, so when I send her a text, and she replies I think my life is going well and I am particularly enthused about MWI branches arising from a universe where Serina texts me, I then press “make proton” on my phone, and the phone makes some protons out of neutrons. That generates a nonfinite (proton at nonchronologically finite universe version) number of universes that branch from one where Serina communicates with me. I could even press on “make lots of protons” if Serina says something like, “I like you” or “let’s meet”.

AI and software developing MWI technologies: With MWI technologies it is my perception it is endless quadrillion of times better to write them immediately rather than wait a moment to write them as a vast plurality of MWI branch universes will potentially benefit from new, accurate, actual, technology producing MWI content; that suggests that AI (artificial intelligence) writing, communicating, or doing experiments could then validate and quantify the “research on the MWI should be accomplished immediately as it affects endless quadrillions of universes differently if you delay 1 millisecond” way of looking at the MWI. A human that builds an AI that figures out new things about the MWI, or even just develops the math and technology space, a few trillion times faster than a thinking writing human is a thing that could be of value from the perspective of a person like me that values making happier more optimal, Dave Pearce’ headonistic imperative actualized universes. (AI produces MWI research and technology a trillion times faster than me) During 2019 a 4Ghz processor would do 4 billion computations a second, and 250 seconds would be a trillion computations, so an AI doing a few trillion more MWI research things and technology items than I would in an hour is plausible; a few sequential instructions at a parallel 4Ghz AI compared with a few minutes of human thought.

Immunizing against a million topologies; screen antibodies to things like “a torus of alpha helices” or a “square of beta sheets”, or “something made of protein twice as wide as it is long” at human tissue culture. This edits the amount and kind of chemicals and biochemicals shared between cytes. Then find out what these categories, and mathematically developable forms (if it kind of works on one topology, then they can find logical math extensions from that topological shape; immunizing against alpha helix torus is 20% effective at heightening organism, like a human, that is a person’s longevity, so the math suggests: vary diameters, immunize against an “8” and an “88”, and immunize against a tetrahedron made with a torus on each side, and others) of them to find the topological antibodies that cause human tissue culture arrays to be weller and have greater longevity; (immunize against many to mid AMU rod looking groups, curlies, heaps of alpha helices, piles of beta sheets)

Immunizing that prevents senescence could be the effect of screening topological libraries of antibodies. Notably research on senolytics apparently supports this. Senolytics terminate senescent cytes; as a result the senescent cytes cease to export chemicals and biochemicals to their between-cyte environment as well as the circulatory system. Those senescent cyte produced chemicals caused unwellness at other previously well and non senescent cytes. Terminating the senescent cytes causes the well cytes to have things continue to go well, and I think I read that mice that get senolytic therapy are healthier, perhaps phenotypically younger, and have longer lifespans, all from eliminating the chemicals the senescent cytes made. So, could you immunize a lab mammal and then a human, that is a person, against the entire library of chemicals and biochemicals that the senescent cytes produce; such an immunization could have the effect of a senolytic drug as it mops up the nonoptimal chemicals.

So, supporting the screening of topological antibodies, senolytics’ effectiveness and conceptual form apparently supports the idea that there is a whole bunch of things, and that if you treat them as a group, you can get an overall bulk effect, even though the bulk effect could contain optimal and nonoptimal chemical effects simultaneously.

Some different bulk effects at the human body that I think are published as causing benefit are things kind of like: more mitochondria causes more protein production, and more mitochondria thus produce greater wellness and youthfulness. Another bulk effect is putting more genes, of any kind, on histones, I think (possibly) causes greater longevity and fidelity of proteins produced.

As a bulk effect, immunizing against topologies could produce beneficial effects like wellness and longevity at the entire body. The thing is to make a lot of them and screen the library to find the ones where the average and distribution of the blended bulk effect is quantitatively and qualitatively measured as much better for the human than an absence of the topological immunization.

Going with this technology of Immunizing against extensible classifications (like topology) could be immunizing against electric charge of an entire protein. Immunize against everything with -.499 to -5.00 charge and a thousand others from +4.99 to -4.99). this diminishes the amount of the proteins circulating, or zapping those cytes with these charges of protein at their surface; this would have a bulk effect, and then the bulk effects of a few thousand variations, or a few million variations, are listed at a computer with the immunization that produces the greatest beneficial bulk effect at the top of the list.

Screening topological and protein molecular electronegativity: Make a human tissue culture of neuron, cardiac and other human cytes, although multiwell plates already exist, you could use IC production technology to make a 1000 times 1000 grid, which is one million human tissue culture samples per screenable plate. The thing is that if you screen a 1000 times 1000 times physical array you have characterized the effect of more than a million different antibodies on the wellness and longevity of things like neuron and cardiac and other tissue culture, which could be predictive of wellness and longevity effects at those tissues and also the entire organism.

Notably increasing wellness and longevity at the entire organism is the resulting beneficial drug from screening vaccines to topologies at a big array. These new wellness longevity drugs are produced when topologies and electron negativities of proteins are found that have beneficial bulk of physiology effects.

I read that BCAA cause more mitochondria to be at cytes. A person with abilities at planning and creating food, might be able to make a new popular food based completely around BCAAs, possibly a completely new BCAA, with a different amino acid sequence that tastes better than 2019 A.D. BCAA (Noting the mitochondrial amount going up I think I read, has higher wellness (and possibly longevity) effects.

I perceive that caffeine is a 2019 AD popular drug, notably at beverages.

So, can you attach a biguanide (metformin-like molecule) to caffeine, which alread tastes aversive, to make a longevity version of caffeine that is a stimulant that makes people live longer and have less heart disease and less cancer. Lilacs make biguanides, tea makes caffeine, so both at one gene engineered plant could be produced. Along with the rest of the world China might go for longevity tea from a GMO crop.

If you chelate beneficial things, even like a biguanide (metformin-like effects) does the taste become much milder? EDTA seems to be mild flavor. Are there any naturally occruing plant products that are chelation agents? Then you could blenderize and fractionate the source plant and soak the thing to be chelated in the soultion that had the naturally occuring chelator concentrated.

Although ECGC is already at tea, perhaps it could be engineered into coffee.

Curcurmin comes from a plant in the ginger family, perhaps ginger could be engineered to be good for people and make curcurmin. A mild flavored more massive Ginger root with curcurmin might replace the potato

Tea bred or engineered to have 10x as much ECGC, noting tea already produces ECGC.

Finding plants which treat psychosis and schizophrenia, as well as other mental illness, with existing or modified plants, and amplifying their utility, that can be grown anywhere, including the developing world: Make computer chemical models like HOMO receptor docking models as measured from the HOMO (or other molecular affinity modelling bases) effective drug antipsychotics. Then screen those computer model predicted organic simplified, multi-matching chemical structures against, that is: to find similar activity chemicals, at as large a library of as many plant based organic chemicals as is plausible to make.

Producing the HOMO receptor matchable database: Make a library of plant based chemicals: do chromotography then automated concentration band-sampling and then spectroscopy with an automated sampler to find thousands, or larger numbers, of organic molecules at plants. Then these are screened at a computer for HOMO interaction similarity to actual known antipsychotics, then tst them on animals and then humans. These chamicals that naturally occur at plants can then be heightened as to their amount at plants through breeding or genetic engineering. Tht produces a plant that when eaten treats mental illness as effectively as the medical drugs used as the basis of the receptor affinity/HOMO similarity computer database matching.

Finding active antipsychotic molecules at plants: use antibodies to glom things out of a soupified plant concentrate: Have the antibodies look like neuron receptor proteins, that is the antibody looks like a H2T dock site, so it gloms things that fit in a H2T site especially well. Then put them with blenderized plant soup or possibly more effectively, chromotographic molecular mass sorted concentrates, and hydrophilic, hydrophobic, as well as pH modified and even denatured protein versions. These antibodies, noting perhaps the antibodies are generated or improved with computer modelled HOMO complements to the receptors, then glom plant constituents likely to be active at brain and neuron receptors noting that the things they glom at the plant based concentrates are likely to be mentally active, mental health drugs.

Screen plant concentrates with the active protodrug-finding antibodies at dissolved plant tissue at a variety of plant species, perhaps screening the 10,000 easiest to grow plants first. This is a technology to find new plant based antipsychotic molecules. The plants can then be grown anywhere, including the developing world, to provide treatments for psychosis and other mental illness as effective as the established psychiatric drugs used that were used as the receptor-attachment models.

The antibodies’ shape complements something like a H2A or D2 receptor’s shape, that receptor, which when drugged is known to treat psychosis with a previously developed drug. This finds the same receptor affinity with an organic chemical that already occurs at plants. Then use genetics, breeding, or genetic engineering to create larger amounts of that natually occuring at the plants antipsychotic molecule. This would also work for drugs other than antipsychotics. I do not know if this is a new technology or a well known approach to finding pharamceutically active chemicals at already existing plants.

Probiotics that are durable and preclude body odor woulld benefit the homeless socially, as well as benefit those with more optimal lifestyles.

My perception during 2019 AD, having been a homeless person, is that homeless mentally ill persons might like enjoyable things to do, possibly with a human-to-human or human to social companion robot component. Giving homeless people something voluntary to do, could be looked at as a mathematics or computer science thing. If each minute of the day is one simplification or digitalization of activities, then something that gives a homeless person an appealing actionable opportunity with two branches or action opportunities every two minutes could be compared with a thing that occurs once every three minutes but has five branches or action opportunities; simulations could find an optimal frequency of entertainment opportunity and branch opportunity to make a person feel good; combinations of intervals and branches are also possible.

From the perspective of those human beings or possibly also software entities that put thought and action towards making the lives of the mentally ill and homeless more optimal it might be possible to doa software optimization based on resources so the largest number of mentally ill or also homeless persons could be reached with the enjoyable voluntary entertainment.

if this entertainment architecture and experience generator could be run billions of times on a neural network that simulated a human, to output highly predictive (accurate) predictions of actual enjoyment, as well as producing and accumulating enhanced future-beneficial actions and mindset, as well as physiological well being then an optimal form of voluntary amusement could be created for the homeless, the mentally ill, and well persons who are more prosperous.

A cheap computer camera could be ubiquitously available to the homeless, perhaps from being ubiquitous at society, thus frequently available as surplus or in trash, and also easily and ultraffordably available to those who do things to benefit the homeless; The camera disincentivizes others from riffling through or taking a homeless person’s things.

Notably, the camera could use city wifi or simplified phone data, without a phone, to communicate its location on a computer network, like the internet; homeless people could find (geolocate) their things, and see the surroundings of where the stuff was at, as well as possibly the identity of the people who have it. This could also benefit people with more optimal lifestyles.

During 2019 persons of medium affluence sometimes had things like shoes, purses, athletic equipment, transport vehicles, luggage, as well as wallets with fiscal value high enough to cause a $5 (2019 US funds) location reporting camera to be considered as possibly having value. Ubiquitous computer networked cameras could then benefit society, and be available to homeless persons as a result of material surplus, and their presence at trash.

Causing even greater availability of networked computer cameras, perhaps there is some reason to leave electronic gratuity mechanisms with networked cameras at restaurant tables, unless gratuities, legitimately I think, cease to be a part of human-human interactions, notably fiscal interactions.

Unless they are found to be as unethical and nonoptimal as I perceive them to be, gratuities could be enhanced with computer networked cameras. Perhaps sufficient value to make leaving (abandoning, or “its ok to just leave it without getting it back” perspectivizing) networked cameras around is if the human receiving the gratuity used the gratuity accompanying networked camera to say “thanks for visiting, come again, here’s a fiscal savings coupon, be sure to say hi at my social networking page” as part of a “high touch” ingratiating way of generating further interaction, where the further interaction is based on the fiscal interests of the commercial establishment where the camera using gratuity receiver is. It is also possible that the gratuity receiver appreciates the benefit to their personal social network growth as well as possible beneficial non-commercial establishment interactions like cameraderie or their other separate entrepreneurial activities that the gratuity receiving person likes. Human interaction, to my 2019 AD perception, often values a feeling of human likelihood of further enjoyable interaction, perhaps referred to as “interpersonal connectedness”. The camera placed along with the gratuity, and the enjoyable personal followup and commercial establishments fiscal incentive to reattract the visitor (coupons etc.) could combine to make networked cameras omnipresent and ubiquitous, thus making them available to and reaching even the least affluent persons.

So it is possible that some human physiologial children have human physiological parents with varied amounts of attentiveness and applied benvolence and actioned effectiveness at things like getting food from the grocery, providing transportation, companion robots that do parenting at the same ability as 99th percentile or above human parents would pleasantly yet effectively cause self-maintenance in the children like washing, laundry, and sleep timeliness, as well as benefit the children many other ways.

A neural network that runs billions of genetics of personality simulations (big five more amount or less amount of five seperate areas, producing a five letter code, similar to fifour letter MBTI code, makes 2*5*5 possibilities of 50 seperate neural network population branch subcatergories to computer model) of voters or possibly stakeholders, or possibly just just people’s (entire population) support of potential rules that a rulemaking body could produce; it is also possible that if 50% of interested parties’ support is combined with splitting the rest of the population in half, that 75% majority support for some rules or programs would be obvious yet this is in tension with social durability and ethics challenges associated with possible benetits and ethical value of minimization of revenue collection.

MBTI SE might support anything they are used to that they can talk about, which is a force for conservatisim of time-localized conservatism, and risks benefit inflation at a benfit-plentiful society, and reduction of benefits at a benefit parsimonius society.

One thing I could do anywhere is do things that benefit women and girls. Research on what kinds of representative government like instant runoff voting, consesus, or monocameral or multicameral legislatures that find optimal solutions in the presence of persons with menatl forms measured as more frequently occuring at women and girls, like thoughts, feelings, and values; these could be modelled with software and be researched with quantitative experimental research.

The researcher or human social structure technologist, would create as part of their research or engineering technology: diagnostic, a thing where they find an actual but nonobvious solution to what appears to be dilemma. Then the dilemma would be presented to different varieties of management (a thing that occurs at a frequent social form: the company) as well as different forms of government, notably representative government, like instant runoff voting, monocameral or bicameral, or tricameral representatives, direct referendum with any element introducing content and one person one vote deciding; all of these varied forms could be researched as to their effectiveness at producing, and even finding the nonobvious but actually existing solution to the sample dilemma; then benefitting women and girls, the version of the company or social guidance system that simultaneously finds the optimal solution while also making women and girls most satisfied as a result of the system being congruent with the women’s and girls’ quantitatively measured female correlatable beliefs, thoughts, feeling, and values. It is possible that along with the engineering sensible approach of asking people things, and measuring actual people with psychological measurement instruments, that a neural network that was say 99% correlated with actual female behaviors and preferences could be made, and the other system’s likely preferability nd acceptance by women and girls could be utilized. A software version of quantitative female preference, that can be asked anythingh, billions ofg times a second, could be used to create new forms of company structures, benefits, and even the things companies seek; also is the use of billions of “imitation female perspective” responses per second to specify and construct social forms like which variation of representative government is the most simultaneously effective (noting the solubility of an imitation dilemma), mentally and emotionally satisfying, sustainable as to permitting and improving of the future and perhaps even enjoyable.

Of course individual women and girls will differ, but a quantitative data portrayal (like computer software, even a neural network that can accurately predict what a female group will do, prefer, and act on, and their satisfaction with the course of action and also its actual effect) that approximates female presence of being at multidimensional, and with a neural network, possibly congruent even at things (dimensions) not yet asked about or measured; the data richness of ray tracing is also described as one thing that provides data richness and ability to support new kinds of predictions even though it is generated from a very simple algorithm of ray tracing. If I can think of another, besides or better than ray tracing I will describe it.

When a system has parameters, and a neural network deep learning software structure is created to predict a system, does the neural network sometimes, often, never, or can be customized to,: predict completely new parameters as they are introduced as new things, i.e. if the neural network is great at recognizing airplanes, does it, depending on some engineering, data set training, or other describable or software engineerable thing have , like ray tracing preserve shape, color, and preposition-like relationships between things that could be separted into separate objects, all from a simple, bounce and raytrace algorithm. Another option is to bifurcate the neural network into two further versions, one of which could also report on or predict something like entertainment ticket popularity.

That is, is there some mathematics of neural network that codes as yet unasked parameter things; this seems like it could be possible as if you just define light and objects with software, you get entire multipart visuals. so if you asked on a different occasion you could actually find round things or blue or white things based on the richness of the original data model, which at this example would be ray tracing.

So are there machine learning AI software representations, that like ray tracing bring a lot of as yet unasked dimensionally valid data to a software embodiment? Finding the mathematics and computer science of neural networks, deep learning and AI models where you can ask more of the function as well as the dataset may be a beneficial area of software and computer science.

Benefitting women and girls with AI that simulates women and girls, and can iterate a billion simulated female perspectives, thoughts, and feelings, on variations of a technology, rule set, guideline, or even physical object form. hypothetically, forming a society it might turn out that based on a billion runs of a neural network that simulates a few hundred million women and girls, that women and girls benefit materially and psychologically from a tricameral (similar to senate, experts (technocrats), and representative) legislature with term limits.

It seems like there could be trends in that data that do not have names at the time the software was written; if the output of the software were visual, a person, that is a human, might notice that graphical shape, trend or object. Then the person would give the object they saw a name, and then the human, or the software could use that newly identified thing as a predictor or correlatable, a noun, or at some software even a verb, function, or “representative thing” that could possibly be simplified with a much littler function or perhaps a neural network.

At woman and girls being predicted with a neural network the AI might come up with an unnamed trend, a data cluster that could be named, tht might be researchable, technologizable, ancourageable, diminishable, discussable, and even the source of comedy and entertaining discussion; for example what if the software were the first to notice open body language as causing greater interpersonal happiness?

People could have a new thing to talk about, and companies and individuals could try out having open body language and seeing what it does, and having something fresh to discuss, and it is possible a person could even generate fresh amusement or comedy from the incongruity of a person having amplified open body language while dancing

A neural network that runs billions of genetics of personality simulations (big five more amount or less amount of five seperate areas, producing a five letter code, similar to fifour letter MBTI code, makes 2*5*5 possibilities of 50 seperate neural network population branch subcatergories to computer model) of voters or possibly stakeholders, or possibly just just people’s (entire population) support of potential rules that a rulemaking body could produce; it is also possible that if 50% of interested parties’ support is combined with splitting the rest of the population in half, that 75% majority support for some rules or programs would be obvious yet this is in tension with social durability and ethics challenges associated with possible benetits and ethical value of minimization of revenue collection.

MBTI SE might support anything they are used to that they can talk about, which is a force for conservatisim of time-localized conservatism, and risks benefit inflation at a benfit-plentiful society, and reduction of benefits at a benefit parsimonius society.

One thing I could do anywhere is do things that benefit women and girls. Research on what kinds of representative government like instant runoff voting, consesus, or monocameral or multicameral legislatures that find optimal solutions in the presence of persons with menatl forms measured as more frequently occuring at women and girls, like thoughts, feelings, and values; these could be modelled with software and be researched with quantitative experimental research.

The researcher or human social structure technologist, would create as part of their research or engineering technology: diagnostic, a thing where they find an actual but nonobvious solution to what appears to be dilemma. Then the dilemma would be presented to different varieties of management (a thing that occurs at a frequent social form: the company) as well as different forms of government, notably representative government, like instant runoff voting, monocameral or bicameral, or tricameral representatives, direct referendum with any element introducing content and one person one vote deciding; all of these varied forms could be researched as to their effectiveness at producing, and even finding the nonobvious but actually existing solution to the sample dilemma; then benefitting women and girls, the version of the company or social guidance system that simultaneously finds the optimal solution while also making women and girls most satisfied as a result of the system being congruent with the women’s and girls’ quantitatively measured female correlatable beliefs, thoughts, feeling, and values. It is possible that along with the engineering sensible approach of asking people things, and measuring actual people with psychological measurement instruments, that a neural network that was say 99% correlated with actual female behaviors and preferences could be made, and the other system’s likely preferability nd acceptance by women and girls could be utilized. A software version of quantitative female preference, that can be asked anythingh, billions ofg times a second, could be used to create new forms of company structures, benefits, and even the things companies seek; also is the use of billions of “imitation female perspective” responses per second to specify and construct social forms like which variation of representative government is the most simultaneously effective (noting the solubility of an imitation dilemma), mentally and emotionally satisfying, sustainable as to permitting and improving of the future and perhaps even enjoyable.

Of course individual women and girls will differ, but a quantitative data portrayal (like computer software, even a neural network that can accurately predict what a female group will do, prefer, and act on, and their satisfaction with the course of action and also its actual effect) that approximates female presence of being at multidimensional, and with a neural network, possibly congruent even at things (dimensions) not yet asked about or measured; the data richness of ray tracing is also described as one thing that provides data richness and ability to support new kinds of predictions even though it is generated from a very simple algorithm of ray tracing. If I can think of another, besides or better than ray tracing I will describe it.

When a system has parameters, and a neural network deep learning software structure is created to predict a system, does the neural network sometimes, often, never, or can be customized to,: predict completely new parameters as they are introduced as new things, i.e. if the neural network is great at recognizing airplanes, does it, depending on some engineering, data set training, or other describable or software engineerable thing have , like ray tracing preserve shape, color, and preposition-like relationships between things that could be separted into separate objects, all from a simple, bounce and raytrace algorithm. Another option is to bifurcate the neural network into two further versions, one of which could also report on or predict something like entertainment ticket popularity.

That is, is there some mathematics of neural network that codes as yet unasked parameter things; this seems like it could be possible as if you just define light and objects with software, you get entire multipart visuals. so if you asked on a different occasion you could actually find round things or blue or white things based on the richness of the original data model, which at this example would be ray tracing.

So are there machine learning AI software representations, that like ray tracing bring a lot of as yet unasked dimensionally valid data to a software embodiment? Finding the mathematics and computer science of neural networks, deep learning and AI models where you can ask more of the function as well as the dataset may be a beneficial area of software and computer science.

Benefitting women and girls with AI that simulates women and girls, and can iterate a billion simulated female perspectives, thoughts, and feelings, on variations of a technology, rule set, guideline, or even physical object form. hypothetically, forming a society it might turn out that based on a billion runs of a neural network that simulates a few hundred million women and girls, that women and girls benefit materially and psychologically from a tricameral (similar to senate, experts (technocrats), and representative) legislature with term limits.

It seems like there could be trends in that data that do not have names at the time the software was written; if the output of the software were visual, a person, that is a human, might notice that graphical shape, trend or object. Then the person would give the object they saw a name, and then the human, or the software could use that newly identified thing as a predictor or correlatable, a noun, or at some software even a verb, function, or “representative thing” that could possibly be simplified with a much littler function or perhaps a neural network.

At woman and girls being predicted with a neural network the AI might come up with an unnamed trend, a data cluster that could be named, tht might be researchable, technologizable, ancourageable, diminishable, discussable, and even the source of comedy and entertaining discussion; for example what if the software were the first to notice open body language as causing greater interpersonal happiness?

People could have a new thing to talk about, and companies and individuals could try out having open body language and seeing what it does, and having something fresh to discuss, and it is possible a person could even generate fresh amusement or comedy from the incongruity of a person having amplified open body language while dancing

[[Ok, so if they could grow long staple cellulose fiber as algal mats it could be cheaper than actual wood But what about the particle board glue? It is possible the algae could make that as well. This benefits the environment as it replaces wood materials from nature, notably wild trees, with things growable in cheap, nonsterile tanks. No, it is otherwise, the labor to harvest a tree is perhaps 2-5 minutes with automated shears and the tree has a mass of hundreds of pounds, so the algae is not cheaper. There could be ethically sourced cellulose fiber preferences though, Ikea might prefer algae grown fibers to wild growth tree fibers.

Perhaps socially contextualized algae cellulose and tree farms could supply materials to build things from wood or algae cellulose products; my perception is that people in the US would remit a premium during 2019 AD to have higher energy efficiency and things like solar. So, at various forms of building around the globe, renewably sourced cellulose from things like algae and tree farms could have a share, perhaps a large share, of building material and paper consumption based on consumer sociocultural values. Then again, as far as I can figure out, algae based cellulose is not cheaper than a 2 minute snip from a tractor with shears.]]

Longevity things, the idea is that the greater the longevity the greater benefit to humans, that is people, from people who are beneficial to others; advertising longevity technologies to all humans, that is people, is optimal, yet if advertising and communication efforts had an amount reaching less than 100% of earths population then triaging the advertising to encourage beneficial people to live longer would create measurable benefit to all the people considered as a group. The other option is instead of triaging just figure out a form of advertising that reaches everyone on earth, effectively enough to produce longevity causing actions. I am reminded of the artificial satellite banner ad in the sky technology. It just orbits the earth, telling people to get and take longevity drugs, on a pixel-addressable screen that communicates at all written languages.

metformin 3 times a day; if sustained plasma concentration goes with actual amount of longevity increase three times a day dosing might actually cause 1/3 more longevity effect; also is there extended release metformin. Getting that pill could work better as well.

epitalon (20 something %)

sleep hygiene, I perceive I read that people that get 8 hours of sleep and sleep through the night live 5% or, (perhaps I misremember) 10% longer.

If I take phenylethylamine once a week, then each century of living is 52*100*20 ideas or 100,000 ish ideas and technologies that are new to me, with me preferring they be things that benefit humans, that is people. So apparently me changing my sleeping habits could produce 50,000 to 100,000 more ideas from greater longevity.

Eununchs live, I perceive about 14 years longer, so cyproterone acetate, chemical castration could be a longevity drug.

Rapamycin, I perceive one rather lengthy treatment, caused rodenst to live 60% longer.

antiinflammatory drugs of some kind, aspirin and ibuprofen and naproxen, I do not know if COX-2 is one of them could cause weller longer lifespan, “chronic systemic inflammation becomes increasingly associated with risk of death, loss of cognitive function and increasing dependency”

Legumes might be longevity foods, “every 20-gram increase in legume consumption produced a 7-8% reduction in mortality with or without controlling for ethnicity (p = 0.02), while “other food groups were not found to be consistently significant in predicting survival” “Well-known legumes include alfalfa, clover, beans, peas, chickpeas, lentils, lupins, mesquite, carob, soybeans, peanuts”

A food blurb: “outcomes of more than 138,500 people ages 35 to 70 worldwide for an average of nine years”…“The people in the “healthiest” group consumed 54 percent of their diet from carbohydrates, 28 percent from fats, and 18 percent from protein. The least healthy ate nearly 70 percent of their diet in carbs, about 18 percent from fats, and 12 percent from protein.” Cheese, avocados, vegetable oil spread that advertises as beneficial and peanut butter could possibly be beneficial

Are you aware of any drugs that when taken cause a longevity effect that occurs from a brief plasma half life, once a day dose?

Some longevity chemicals with a sustained presence at the body are, I think, supported with things like metformin circulating constantly, possibly doing some AMPK thing continuously.

Are there longevity chemicals that function as longevity increasing switches? Are there things where a dose, perhaps a high amplitude, narrow duration of effect dose causes a published longevity effect?

Two (or maybe just one) that I can think of are melatonin and the peptide epitalon. At the brain, melatonin is released as a pulsatile event, so possibly brief duration of action. I think I read melatonin make laboratory rodents live longer.

Epitalon is a 4 amino acid peptide that makes laboratory animals live longer (I perceive mid 20%) and be weller. I do not know much, but as a peptide, if you snort it, I can imagine it lasting minutes rather than hours at the circulation, so perhaps it is a longevity turn on switch drug. Melatonin is a pineal gland secretion product, and epitalon is an engineered version of a pineal produced peptide.

It would thrill me if anyone here had ideas or knew about brief high amplitude dose longevity drugs and chemicals. What do you think some other ones are?

Senolytics also come to mind, “zap the senescent cytes with one course of treatment, live weller and longer afterwards” is kind of different than brief plasma half life longevity drugs.

Quality of life:

They could measure 12 year olds, 14 year olds, 16 year olds, 18 year olds, 22 year olds and 27 year olds to find out whate kind of lifestyle causes tha greatest quantitative happiness, well, being, quiality of romantic life, and school and life achievement and find out which 5 or 10 teen and tween and twentysomething lifestyles, like romantic sexually active teen that does their homweork and show it to their parent nightly that goes to college and gets a scieinces or technology degree and then seeks out employment and internships based on their interests directing them tracked from 12 to 35; also when it is better to become pregnant. The technology is to find out which of these all work together in concert, as compared with just sexually active, just academically rigorous, and just fun single activity and perspective intensive lifestyles.

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AT the human brain there could be a 99th percentile area of reliability and a 1th percentile of reliability; such as stability over time, absence of nueronal change,what do variations on the amount of reliability do at humans. Do well humans have better reliability even at their personal 1th percentile structures? Also,

What areas of the human brain are at 99th and 1th percentile of automatic regeneration; improving the regeneration of the 1th percentile could be a healthspan or even longevity effect. Drugs, such as new drugs that Halt or reverse decay at the 1th percentile of brain areas resistanct to decay or messed upness could

chlorophenoxy NMN might pass the blood brain barrier causing mitochondrial improvement and better NAD things at neurons and glia. Another version might be

Chloro or other halogenated curcurmin could a a senolytic, wound healing drug that could have other benefits.

Along with the idea of a washcloth impregnated with beauty peptides, giving hundreds of beautification treatments per cloth, is the idea of a washcloth with an electret surface charge, or even piezoelectricity like PVDF that causes the chemicals in it to be even more effective.

It is possible that electret bandages or band-aids soaked in beneficial chemicals could be quantitatively measured as being more beneficial than non-charged bandages from chemical migration.

Could chlorophenoxy moiety or other moieties that cause passage through the blood brain barrier heighten passage of beauty chemicals like peptides through the cytomembranes of the dermis making these beauty chemicals more effective? Even melatonin, which I think I read accumulates at the nucleus, could be linked to topical beauty peptides and possibly things that modify histones, to heighten transport of beautification chemicals like peptides and poroteins to the nucleus.

A washcloth, impregnated with beauty peptides, which might actually be effective already at micrograms, such that every time you wash with it you get a coating of beauty peptides. It is noted that the wascloth gets utilized when rinsing, so the peptides coat the face after washing is accomplished.

A scientific survey, and an engineering and medical product development application of the data from a survey, of the bacteria at normal skin, as well as particularly well, younger than actual age appearing skin, noticeably facial skin, could find a group of bacteria, not previously known to be beneficial, that are quantifiably beneficial to the skin. Increasing the beneficial skin bacteria could be the basis of topical probiotics, prebiotics, surface topicals like things that adjust pH, or surface hygroscopicity (things like autowetting naPCA, or alternatively surface moisture absorbing things like polyacrylimides or polyacrilic pre-gel powders). These topical, systemic (oral or other systemic drug delivery), or possibly even changing the characteristics of the skin bacterial ecology with laser treatments, laser-resurfacing or microdermabrasion mediated bacterial ecology changers at skin to produce skin wellness and beautification from favoring some bacteria over others.

A scientific survey of well skin and skin that appears, or also is biochemically and tissue-characteristic younger than chronological age, that is used to create and engineer new products may also find non acute, non-“breakout” bacteria that are harmful, giving the opportunity to remove, treat, or also replace these nonbeneficial bacteria with harmless or beneficial bacteria.

There is even the possibility that bacterial-species specific antibacterial chemicals like oral or topical antibiotics or different chemical topically applied medicines (possibly species specific topical Quat disinfectants, RNA drugs) could make just the non-breakout-causing while still harmful, thus of benefit to remove preclude or kill, bacteria cease their living and activity at the skin.

Customizing skin surface with lasers or other physical treatments to create more beneficial skin bacteria ecology: changing the characteristics of the skin bacterial ecology with laser treatments, laser-resurfacing or microdermabrasion could be structured around the number and ratio of what might be topological hills and valleys, (possibly kind of like gyrii and sulcii shapes) at the skin surface, optimally the living cytes, as well as possibly the accumulated keratin outerlayer; so, laser or otherwise treat the keratin, and perhaps more optimally, the living dermatocyte layer, into bacterially optimal shapes, among which some possible versions are little regularly spaced ponds of depth, dendritic looking connected microchannels, or the more high surface approach of a greater number of high plateaus which create a greater amount of high flat surface areas. The modified surface heightens and benefits more beneficial skin organism ecology, causes quantitatively measured increases in beauty, the numbers of beneficial bacteria that have been correlated, or Koch’s postulates proved, to increase beauty, youthfulness of appearance, or also better skin healing abilitity.

It is possible that acne comes from a multi-bacteria effect, and replacing one or more of the component bacteria of the multi-bacteria effect, at the skin, with different better probiotic versions of skin bateria could reduce skin disease, preventing reducing or even curing acne as well as causing other dermatologic nonoptimalities to cease. At a skin ecology, say one bacteria produces a proteolytic enzyme, and another different species of bacteria causes acne. Perhaps the proteolytic enzyme produced at the first bacteria opens the skin to causing microreas of infection or just infection-prone microareas that the acne bacteria then uses, or would have used if the skin probiotic had not replaced the proteolytic version of the bacteria with a better, nonproteolytic one, likely of the same species and nearly the same strain, as growth sites.

Another possibility, going with the perception that acne is sometimes linked to hair follicles, is that changing the bacterial species of the ecology of the hair follicle would also reduce, preclude or cure acne that has a hair follicle component; having hair follicle sized actual areas of beneficial dermatological bacteria, like dermis probiotics, that occupy and reproduce even better with the beneficial bacteria depots creatable at hair follicles.

I perceive there might be multispecies bacterial biofilms. Are there bacterial biofilms that, even if they are without causing skin breakouts, are nonbeneficial? If there are non-breakout bacterial biofilms that should be cured or changed, then dermal surface probiotics, skin treatments like: lasers, chemical peels, sonication, or dermabrasion, as well as topical drugs and systemic drugs, which replace some of the bacterial species at the biofilm with other species, or even a more beneficial strain of the same species, would increase skin wellness and appearance from changing the biofilm’s effects on skin as well as changing any bacteria-bacteria interactions to be more beneficial.

It is possible that harmless viruses, notable for not being cytokilling, but still transcribed at cytes, could cause dermatocytes that get the virus to cause the production of beauty peptides and proteins, and possibly even wound-healing chemicals while being non-cytoterminating and harmlessly infecting cytes. Notably systemic or oral as well as topical methods of this beneficial viral infection might initiate beneficial virus incorporation into skin cytes, as a topical treatment, possibly after the dermatocytes are made more easily beneficial virus infected after a chemical peel, dermabrasion, sonic, or laser treatment. It is even possible that an physical beauty treatment like laser or chemical peel or ultrasonics, or dermabrasion, or unintentioanl injury like an abrasion, could cause the virus to be activated notably because, and when, the dermatocytes were dividing to restore the skin.

Dermatologically beneficial virus that stays resident, and activates from normal cytodivision, a topical, systemic, or physical treatments (lasers, chemical peels, dermabrasion, sonic treatments), which possibly even uses viruses that pre-exist at the environment, that benefit the dermis are a technology. This is a little different than gene therapy. Dermatological gene therapy also has value.

Heightening the activity and infection capability of beneficial viruses: I have not heard of any chemicals that cause normal human cytes and tissue to, alongside the application of a beneficial virus, be more easily infected. Drugs that affect IPMAT to favor cytodivision could amplify the spread of, and proportion of infected cytes with beneficial viruses. It is possible that some chemotherapeutics like the longevity drug rapamycin increase viral infectivity.

Topical rapamycin might have a beneficial virus’ heightened infectivity effect, while also having a longevity youthful cyte and tissue producing effect from Rapamycin’s already published effects. The application of materials that heighten viral infectivity, copy number production, and also the amount of the beneficial chemical the virus codes to produce (as well as chemicals that the virus causes the production of that occur at unmodified viruses that occur at anture, without additional genetic coding at the virus; noting that some viruses may just be measured as having a beneficial effect, and that amplifying the proportion of cytes beneficially infected, the virus copy number, and possibly the amount of secreted proteins could be basis for greater beneficial effectiveness). It is possible that the viruses’ dermatocyte (or other cyte and tissue) action causes greater beneficial measuable intra-cyte that is between cyte, beneficial secretion of things like proteins, peptides, or even possibly ions as well.

application at tissues that can be reached with surface ot topical treatments; noting that published material at the scientific literature describes systemic beneficial longevity effects of rapamycin.

Another way to increase infectivity of beneficial viruses: I think I read that omitting a night of sleeping might double the infectability of the flu virus; It is possible that the chemical effects that cause that effect can be duplicated at the dermal surface (or systemically) with a topical or systemic treatment, heightening the effectiveness of incroporation of beauty and wellness viruses into human skin cytes.

It is just possible there are amongst 2000 preexisting natural skin viruses that are already a harmless to skin cytes there could be a .5% that are actively beneficial from the effects of the viruses on beautification, preferred skin quality, such as color, softness, and even things like controlling or blocking hair growth and fidelity of healing. These viruses could then be applied to the skin medically, it is imaginable after a laser or chemical treatment, or even, noting it is a skin-active virus,

Is there a .5% of beneficial viruses out of perhaps 2000 viruses that effect endothelial linings, that there is a bodywide epithelial and tissue membrane beneficial virus? This could be gene therapy to improve things like the GI tract lining, the epithelial layer of the vascular system, as well as a variety of other endothelial cyte structes and tissues throughout the body. Improvements to the blood brain barrier, and the gonad-blood barrier, either increasing or decreasing the passage of circulating chemicals, could be possible

Senolytic drugs that kill senescent cytes are published as increasing wellness and increasing longevity. Some 2019 AD senolytics are chemotherapy drugs. Some viruses are used to kill cancer cells. Finding, or genetically engineering a virus that kills off only senescent cells is a beneficial new invention. This has the benefit of the virus being able to stay resident in the body, providing continuous senolytic action only on senescent cytes. This is a new longevity and wellness causing virus.

It is possible that systemic, or just possibly topical, chemicals or drugs that increase capillary amount, path morphology, or diameter could increase dermal tissue resilience, feel when touched, healing capability, enhancements to the chemicals and cytostructures produced at the dermatocytes (like more collagen, or better cytoosmotics and beneficially heightened cytovolume (which might be externally perceived as the person using moisturizer, but without actually using moisturizer)) which causes greater beauty, and may also increase things like resistance to illness, and velocitize healing. At sites where hair growth is a preference, then capillary amount, path morphology, or diameter could enhance the preferred effect on hair.

Light activated tissue growth factors as a dermal tissue and beauty increasing technology: Linking tissue growth factors to photoactivatable molecules produces light activated tissue growth factors. Noting the easy photoacessability of skin, as well as the ability to cofocalize light, as well as the possibility that ambient daily light could turn on a photoactive chemical at the skin just from experiencing natural and ambient artificial illumination, photoactive dermatological beauty and youthfulness drugs have technology applications. Turning things like porphrin linked growth factors or rhodopsin linked growth factors or some eentsier photoactivateable molecule linked to growth factors, to turn on and grow tissue and cause beneficial cytodivision at the lit up area, possibly from just ambient light could possibly do things like directly opposite UV photoaging, causing sun exposure to have a net beautification and youthification at dermis.

Online material: Are there any chemicals, like proteins or chalcones, which change their shape or charge distribution when exposed to sound? If so then focused acoustics at tissue depth as well as near-surface acoustic energy transmission could activate drugs; acoustically active drugs have numerous applications. Perhaps gentle acoustic waves at the brain could activate CNS drugs at a 1 mm voxel size.

It is even possible some beneficial cardiac medicine could be accomplished, as well as the chemotherapy agents. It is just possible that focusing acoustic waves at the placenta, while drugs quatitatively measured as being harmless or even beneficial to the fetus, were around, that placental function, efficacy, and even shape for risk reduction could be enhanced; Sonic waves could cause a normal or undersized placenta to grow to the size most liked to fetal and baby well being, that could come from vasodilation during the early growth phase of the placenta or the application of acoustically activateble growth factors. Also, it is possible longevity drugs could be heightened as to their localization and activitywhich It is possible a systemic dose of tissue growth factors,

Notably, many kinds of drug localization can be technologized to benefit a pregnant woman and her fetus and baby; whether it is tissue accumulation of a chemical or drug, photoactivation, sonic activation, or even site injection, localization causes the beneficial-to-the-mother drug to omit interacting with the fetus.

Online content: GSK: sonically activateable drugs create drug effect localization. Chalcones (zubbles might respond to sound), also stringy goopiness, biopolymers like keratin, chitin, or polyhydroxyapatite, or published as bioabsorbing, suture materials, as well as metal microantennas like gold; the antenna fibers sized for sonic-frequency receptiveness (perhaps it is very tiny antenna sized sound frequencies like far ultrasound or something)The acoustically activateable drug antennas could be things like hydroxypatite fibers that pick up sound, as could possibly some fibers of protein like keratin, chitin, possibly even cellulose,; perhaps a published biodegradable suture material could be microsized to pick up sounds, and have a chemical groups (halogens? PVDF kind of effect, but at keratin or hydroxyapatite fibers, gold fibers) on it that change charge when acoustically stimulated thus changing the charge on the active drug, causing a purposed effect.

Are there any producible, or naturally occuring at tissue biopolymers, protein shapes, or just tissue morphologies that function like a telescope array? That is a grid or exapnse of 1000 eentsier proteins, occuring at a tissue, is like a radiotelescope array, able to pick up and respond to

(emergent property: the bigger a tesselated protein grows, it could spontaneously produce, or even predictably produce something like an array telescope (radio telescope array measures big frequencies with eentsy component parts); This without one to one photon->e- charge or

CCD (charged coupled device) like effects and various molecular charge cascades and accumulators might also be possible like: piles of e-charge ready to change and accumulate at a particular molecular direction if they get an eentsy amount of energy from a photon or other energy source; among numerous things that could be produced wioth structures, a CCD or a current multiplying cascade could be made from layered (numerous kinds of layering: one is an amino acid linked to another, repeatedly to form a peptide or a protein, A highly branched peptide could lay on top of itself, and when something caused the molecule to have an electrical charge shift, movement to another part of the molecule, or change, the two-treelike-brooms overlain effect causes charge patterning at the entire polymolecule (like from nodal tesselation to gentle gradient to a different nodal looking tesselation); although modellable with quantum mechanics at molecular modelling software, this branched molecule layering effect is something I think of as analog and having gradients, although the engineering value of a digital approach to polymer or peptide overlain trees that make charge structures (CCD, current cascade, biopolymer diode voltage doubler, biopolymer frequency doubler)is there as well.

One topology of layered polymers like biopolymers like peptides or proteins, yet possibly completely different biopolymers, chitin (which has a nitrogen), the chitin polymer molecularly reshaped, perhaps branched, or a pendant moeity differently arranged, differently, with the polymers or biopolymers, slightly modified to have a piezoelectric, electret, or stimulus-responsive effect (photons, acoustics, motion/bending/temperature/physical chemistry effect) that then causes charge concentration cascade, (current cascade). 11 base pair DNA can make a diode, perhaps it is possible to make an amino acid peptide (or even just a honking big 1100 AMU molecule of some kind (1100 amu molecule is like the amu equivalent of near 14 glycines linked together) Then with the biopolymer, peptide, or 1100 AMU (or less) biochemical, a thing made out of that can double voltage or double frequency.

Doubling voltage, current, or frequency at new chemical or a purposefully built structure possibly made with a biopolymer (or possibly a polyboron) or an organism based system gives new engineering capabilities.

Is there a way to step up a molecule’s activity, perhaps based on e- charge and HOMO, where each of 2 or three activations (beams) sequentially hops the molecules reactivity up a level. I am reminded of taking off the PO4s from ATP one by one, if you did that and the core ws something other than adenosine, removing each PO4 might actually increase the rectivity of the core, the rest of the molecule, so each pass of activation beam would hop the chemical up a number of levels at its environment from the beam: charge-surplus-wobbles each of the PO4s off. As sort of an extreme example: where the absorption of a beam, would pop a chelation molecule (moiety) off of an ultra-reactable, even one like CN (cyanide); if you can use localization from light or sound to modify molecule charge, and possibly even use something like a voltage doubler amino acid structure, then you can do things where the energy would not otherwise favor the reaction, like popping off a chelation molecule.

Popping off a chelation molecule around a chemotherepeutic, cardioactive beneficial drug, drug beneficial to a fetus, longevity drug, beauty drug, or antibiotic makes a molecule that is just active at the are of localization stimulus like a cofocalized acoustic/photonic beam. So, could having a wide field hop up the molecule 1 level, then a narrow beam, just activate the hopped up molecules at a narrow area; This remnds of engineering first and second stage rockets, it is useful technology.

If you put a frequency doubling or current doubling or voltage doubling molecule at a gaussian (or even polarized) field, does it cause the molecule at the center of the beam to have higher amounts of activation? Sort of like, if you put a spotlight inside another spotlight (gaussian with high mid-distribution peak), and that illuminates something that doubles the photovoltaic voltage or even an acoustically responsive molecule’s charge shift/piezoelectric effect, does the comnination of those two things give higher sptial resolution and localization of the effect? Just grabbing the precise center 10% from the middle of a gaussian distribution of a beam spreading through tissue seems possible. Then when that middle 10% reaches the frequency doubling/current doubling biochemical (like an amino acid diode bridge moiety on a drug that becomes active when there is a change of charge or HOMO shape) does that promote activity of the drug

Another way of looking at this, is, with flashlight fingers, is there a peaked distribution of energy as compared with a uniform illumination effect? If there is could grabbing an energy profile out of that light/sound distribution’s peak create an energy profile that could be matched to a drug? So if you beam light or sound into the body, from 1-30 cm deep, or even vertically at a human, then look for and find any existing spatial distribution peaks at the actual tissues and organs (if applicable), then note their energy level (like joules/cm) at that localization area, then use a tuned drug that responds to just that energy (joules/cm) does the area of the drug activity have higher localization? let’s say there is 20% more (120 decijoules) light at the middle of a gaussian beam at 2 cm deep in flashlight fingers, but most of the distribution throughout the flashlight illuminated tissue is at 100 decijoules, can you then specify a drug which only responds to 115-125 decijoules/cm energy levels with a charge-effected drug activity? That would cause just the optimal part of the beam, even a diffuse bem, to activate the localized beneficial drug or chemical. One thing that comes to mind is that the flashlight might be 200 decijoules at the body surface, then gradually gradient to 100 decijoules at most of the tissue, that means there are non localizion-purposed areas, say 1 cm from the surface (the localization area is the gaussian center of the beam at 120 decijoules at 2 cm deep, at some 3d area) that the drug would be unintentionally active at, unless the next technology item is made a part of the system:

Prior to the technology described immediately here, zone energy gradient would have caused drug activation at an overlayer different than the beam center energy effect, that would have caused a zone of drug activation outside the localized area. It is possible this could be improved with cofocalization. If you are cofocalizing seven 20 decijoule beams to make a 140 decijoule focus, and the focus diffuses to produce a zone from 100 to 140 decijoules around it, if the drug is only active at 120 decijoules that makes a torus shaped drug activation zone and an absence of any near surface gradient layer with a drug activating area of the beam-passing-through-tissue gradient layer.

Can you beam some kind of radiation like EM, photons, or acoustic energy into a human where the radiation actually diffracts because of the size of the microfeatures at the human tissue? If that is possible then you could nodal concentration effects at diffracted waves, which might be at higher resolution internal to the body than if radiation shapes were just beamed at the body, It might work with teeth or even ribs, I have no idea at soft tissue though. If there are microstructures at the body that cause predictable internal diffraction and nodal overlap perhaps these could be used for site localization at tissues or even cytes to do medical things like activate drugs, or cause drugs to accumulate and concentrate at localized areas.

Another use of a double slit or energy/chemical binomat drugs is that you can use the bandpass of external energy activation of a drug molecule (say at 120 decijoules/cm, but not at 100 or 140 decijoules/cm).

There might even be some nifty way to use physical chemistry bandpass or notch filter at a chemical binomat/ducolumn/multicolumn colonnade to get a drug or even a new genetically engineered protein to only react or, as a protein, change to a new differently active shape, with something like precisely between 200 and 300 molecules of ATP per nanoliter but not 100-200 or 300-400. I do not know of any bandpass drugs, or engineerable enhancements to human genetics, that exist other than the really casual, easy to do much better than, “make some double slits or multicolumn colonnades with alpha helices”.

Notably at a drug binomat, the area, like proteins or cytoreceptors that are physically near the binomat are the things that have their distribution changed and optimized; on both sides of the binomat (or double slit effect molecule) diffusion would cause the drug to reach an ambient gradient at the cytoplasm. It is just that right near the binomat (or double slit effect molecule), like with the biomat say at a dendrite or synapse, the (nootropic) AMPA activateable drug would concentrate there.

Thinking of people that value reengineering neurons to beneficially give humans heightened well being and capabilities, modifying cytoneuroanatomy to have binomat/double slit/multicolumn colonnade/ customized nodal interference (*—||||||—*) (or aslo corsshairstechnology previously described) structures, likely proteins or peptides, but lipids or physical membrane crenellations, are a possibility,

Thinking of synapses and dendrites, it is possible there could be a protein or other structure of drug that functions like a binomat SelectiveDopamineReuptakeInhibitor (SDRI) or SNRI or even SSRI. Where the reuptake of the neuroactive chemical is inhibited because there is a protein or chemical biomat or double slit in front of it, possibly floating around the synapse like a screen.

One application of a physical chemistry drug binomat the notch filter at a biochemical system, notably a drug system, is making it so drugs that effect neurotransmitters are only active at particular concentrationsof neurotransmitters, and can also be used to always produce a neurotransmitter drug effect the size of the notch filter’s envelope. That way if you took awesome dopamine supplying drug, it would always provide 300-400 ng per ml of dopamine, and not more or less, regardless of how your body reacted to, or tolerancized the drug.

Online a way to create greater localization with photons is described, “[they omitted] photoactivation of sufficiently small and well-defined sub-cellular regions [at a plant] with conventional laser illumination in the confocal microscope, mainly because scattering and refraction effects within the root tissue dispersed the focal spot and caused photoactivation of too large a region. We therefore used 2-photon activation, which has much better inherent resolution of the illuminated region. This is because the activation depends on simultaneous absorption of two or more photons, which in turns depends on the square (or higher power) of the intensity-a much sharper peak.” I do not know but perhaps more photons like three photons would create an even geometrically narrower area of light or even acoustic/physical chemistry activation from a beam, force or light beam. It could be functional to engineer localization drugs to do phototherapy with that use three electron (three photon) systems? Chlorophyll is a two electron system, and I perceive that combining chlorophyll with something like an alkali metal, and then reacting that product with an alkali metal grabber could link chlorophylls together. Actual three photon systems at photoactivateble drugs and chemicals would certainly have different forms, it is just nifty that it is likely possible to dimerize chrolophyll to produce a three or four photon and electron system.

or at a biomolecule, charge, does that make just the gaussian peak center 20% of the tissue area for localization produce a particular charge (voltage) that can effect a drug to be active? So like a porphyrin linked chelation molecule with a CN cyanide at it or possibly a chemotherepeutic gold molecule, only reaches 3.1 volts or the amount it takes to get the chealtor molecule to pop off the CN/gold thus causing the CN/gold drug as a chemical to be active. Does this work better because of the high middle peak at a guassian?

Or, am I just confused

Can you do a bandpass filter on a pile of cofocalized beams to make a smaller area than the cofocalization produces? That produces narrower areas of chemical localization and activation from using frequency/current/voltage doubling/halving biopolymer structures,

Also, with the double slit experiment, are the stripes narrower than the laser dot diameter? If they are then putting the localizer beam through a double slit before it reaches the body could heighten resolution when doing localization of drug activation to benefit humans. There is also the local chemical area version of better localization with a double slit: If the stripes are narrower than the dot then it might be possible to put the localization beam through a molecular double slit, causing higher spatial resolution. While it is not particularly nifty, a couple alpha-helices next to each other like II (||) could be a highly localized double slit, where molecules at the after-area of the || might get even narrower energy beam based activation. It is even possible that a something like an alpha helix duocolumn (or better, some kind of multi column colonnade, kind of like a binomat) makes the things,like molecules and proteins, and even cytostructures, they are next to responsive to customized energy forms, which benefits tissue area, and even cytostructure area drug or chemical localization. Double slits, duocolumns, or multicolumn collonades could be a chemical that makes the other chemicals next to it to be more sensitive to light, or only sensitive to particular energy densities or frequencies this is from novel crosshairs cofocalization, bandpass filtering effects (bandpass energy filters and notch filters are described at other locations here, kind of like 120 decijoules/cm only reach a drug chemical, while 100 decijoules/cm and 140 decijoules/cm are excluded via the alpha helix || double slit/duo column/binomat) or possibly some other kind of radiation from the difference between a |||||| effect and a beam effect; .

Binomat enhanced chemistry: Maybe the double slit or bandpass filter thing even works with a atoms and ions stochastically drifting through and around the double slit, with the duocolumn (or multicolumn columnnade that is kind of like a binomat) of alpha helices causing the stuff that the cytostructures, proeins, or receptors near it to experience be made adjustable.

A science study looking for wave interference, notably the ||||| stripes produced at wave versions of duocolumn slits (or multicolumnar biomats), as well as customized binomat concentration effects (bandpass) at proteins (or amino acid polymers) near other things would be nifty. If proteins or amino acid polymers screen and concentrate stuff for their neighbors

Proteins that do double slit concentration or binomat bandpass show the way to desirably technologizable effects as well as new scientific identities. Perhaps then you could look at new class of proteins, called iProteins, then calulate what it is (radiation like photons or EM, or possibly a binomat-like sieving of certain sized atoms, ions, molecules from their neighbors) that they were concentrating (double slit) or letting through (bandpass) and then make some of that stuff (actual chemicals or actual frequencies of radiation) that they double slit concentrate or binomat concentrate on purpose, to be used as a drug and to also measure its occurence and effect scientifically. It is possible that if there are naturally occuring, as well as engineerable, protein or peptide double slits (or other focalize near a neighbor things similat to but better than a double slit, or also like chemical binomat bandpass filters) at biological organisms that the atoms, molecules or radiation they concentrate and modulate could be noticeably active as drugs or even new kinds of Biological Effect Rays(BER) that people could make on purpose, aim at living things, and see what they do. EM biological effect ray Drugs made out of things like alpha helix arrays or something better could even effect the response of living organisms to EM biological Effect Rays. Perhaps just as sunscreen can effect cytowellness from blocking UV, and a container of warm water can soothe mesnrual cramps, a BER refocuser, blocker, or supplemental dose of BER radiation could cause benefit at humans.

Say you want your chemotherapy photodrug to only affect neurons but not microglia, or only microglia but not neurons. Well, one possibility is something like putting methylene blue, or a mitochondria colorizer chemical, at the bloodstream, and then since the microglia have 3 times as many mitochondria as the neurons (or perhaps the neurons have three times as many mitochondria as the microglia) one or the other is three times more blue than the other. That way when you illuminate both with therapeutic light that activates drugs, one of the cytotypes only aborbs one third the light dose, and thus the chemotherapeutic dose at those cytes is just 1/3 that of the preferred tissue. Also, noting bandpass and notch filter drugs, proteins, amino acids and chemistry from double slit/binomat drugs and effects, it could be possible to create a chemotherapeutic molecule that only responds to 120 joules/cm with drug activation, and that 100 Joules/cm or 140 joules/cm are excluded from activation, narrowing the radiation activated dose to just specific cytes, tissues, or even, and this is novel to me, cytoorganelles. so the idea is then that the methylene blue makes everything but just the particular neurons, for a particular neurotransmitter.

Methylene blue has a possibility s an actual phototherapy optimization drug as it is published as causing greater longevity and having nootropic effects, so dosing many tissues at many amounts could actually be harmless or beneficial.

Cytoorganelle therapy: use somethinglikemethylene blue to colorize just the mitochondria or just the reeptors some chemiclliek dopamine. Once the organelles are colorized, put a phototherapeutic agent at the cytes, then used ligth to activate them just at specific organelles, proteins, and receptors.

An antibody or aptamer linked photofrequency specific-absorbing quantum dot or fluorophore, or colorizing agent like methylene blue could attach to just very particular cytostructures like proteins, membranes, ribosomes, proteins, mitochondria, the endoplamic reticulum,

Two stage therapy: the gene therapy makes the transfected cytes produce a frequency absorbing color, or even a photoactivateable protein or amino acid endogenous drug, just at the kind of cytes the gene therapy works on, then light is used to activate the phototherapeutic drug at all the transfected sites. This could be used to turn on or turn up the volume at gene therapy drugs, new human genetics, eugenics, and therapies. So a person could could get their neurons optimized with gene therapy or eugenics at the germline, and the neurons could produce an otherwise neutral harmless and inactive photoactivateable drug, then they could further tune up their genetically improved neurons with photonic energy; Perhaps making 10-200% more of some chemoreceptor protein structures at cytomembranes makes the neurons contribute more to cognitive capability and subjective well being; frequency-optimized gene activation and action and beam localization make it possible to have lots of dopamine receptors at the nucleus accumbens, where it is actively perceived as highly euphoric, but a different amount at a different brain structure.

Another application is the beneficial site specific production, amplification and wellness-amplifying, capability enhancing, as well as therapeutic use of growth factors,like human growth hormones, nerve growth factor (NGF) and brain derived neurotrophic factor(BDNF); photoactive protein versions of these and other growth factors produced with eugenics, germline gene therapy, as well as bodywide gene therapy, even at versions where just the liver has experieinced the gene therapy with the purpose of just putting a lot of the photoactivateable versions of NGF, BDNF, HGH and growth and beauty peptides at particular tissues and cyte localizable HGH, NGF, growth and beauty peptides, or BDNF at the bloodstream, mkaes it so you can beam light at some part of the body and make it grow or heal faster. It is possible that cardiobeneficial effects could come from photoactivating HGH or NGF or BDNF at say just cardiocyctes, or just cardioneurologica tissue, or even a growth factor to cause healing after ischemia;

This could be applied to many beneficial new eugenics genes as well as gene therapies. Let’s say you are genetically engineered to produce lots of youthification producing, mitochondria benefitting NMN, then you could use photoactivation to make 3-10 times as much NMN at particular tissues compared with others, benefitting you and the body.

One area of transcription activation useable at gene therapy and new genes at eugenics that is published is photoactivateable histone deacetylase (HDAC) inhibitor, so photoactivating that HDACi would change the amount of transcription, the amount of gene products like proteins, and cytostructures and tissues produced, and possibly the specific genes that were transcribed.

Also, nonvisible areas of the spectrum can be used for photoactivatable genes, gene products, drugs and chemicals, that way the human gets to omit turning bright blue, unless they feel like it.

What is the fewest AMU photoactivatable amino acid sequence, biomolecule, or protein that can be constructed without a metal atom? Online it says there is research on intrinisically spectrally relfecting and abosrbing at the visible range oflight peptides. Also, it could be that just putting a lot of energy into a peptide or protein or other biomolecule at its IR-spectroscopy absorption peak could chemically actiavte that chemical. Say you illuminate some ATP with IR-spec highest absorption photons, it is possible the phosphates are morelikely to pop off easily.

Possible youthification phototherapy: illumination of ATP at IR-spec absorption peak of ATP causes ATP to be hyper reactive, thus lighting up the face with ATP optimized frequency light is quantitatively measurable at enhancing skin characteristics and beauty, possibly causing number of ATP phosphate reactions per second to be that of a teenager. While a person sleeps nonvisible lasers could trace out areas of illumnation all over the persons body to make ATP as reactive as possible which could cause greater available cytoenergy to all cytoprocesses including protein synthesis. More ATP activity at the dermis may be youthifying at the dermis. The ATP amount might sustainably remain at the same amount, even with faster ATP reactivity from mass-spec absorption frequency illumination; I read that the amount of mitochondria decreases with chronological time at humans, so notably, a person during the 20th century AD might have had the highest amount of ATP at their cytes, energizing protein production and other cytoprocesses, including dermal cyte upkeep and replacement; If at a variety of relative mitochondrial amounts the ADP->ATP cycle and reaction and reaction producing chemicals are sufficiently strong and in sufficient quantity, even at older persons, then the more strongly reactive IR-spec illuminated ATP would simply react faster, while maintaining the same as original levels of available ATP because the ADP->ATP biochemistry can convert ADP->ATP as fast as it appears. I have not read about ADP build up at older tissue, so perhaps the ADP->ATP reaction is fast, and not what affects ATP amount.

From a longevity drug perspective, it is possible that a drug, gene therapy, or eugenic germ line therapy enhancement of ADP->ATP regeneration is beneficial. Different cvariations are possible: ADP->ATP already happens faster than ADP is produced, so there are only trace amounts of ADP around at a cyte, or, ADP is transported to some specialized cytoarea where it gets turned into ATP the velocity of that transport process is what directs the rate of ADP->ATP synthesis, another possibility is that something like fewer actual mitochondria at old tissues’ cytes causes there to be less ATP at the cytoplasm to begin with, and to regenerate and diffuse throughout the sytoplasm or be actively transported around the cytoplasm and cyte. If there is just less ATP to be ADP->ATP regenerated then gene therapy that just produces ATP at transfected cytes, and does not use mitochondria to generate the actual availabilizable pool of ATP molecules could cause greater cytoyouthfulness, greater human phenotypic youthfulness, as well as greater longevity.

A wellness and youthification drug, and longevity drug could be producible at when Adenosine, the amino acid, at a new drug form where the adenosine is linked to a membrane transport molecule or protein, could possibly increase the amount of adenosine triphosphate that gets made because there is more substrate adenosine at the cytoplasm to enhance with PO4 groups. One possibility is chlorophenoxy adenosine, the chlorophenoxy group gets it past membranes, then it is available adenosine at cytes; I perceive I read that lipophilic molecules have better trasnport past the blood brain barrier, so as those are cytomembranes that get passed, it is possible that a lipophilic variation of adensine could be an ATP heightening supplement. You might just be able to put a /\/\/\/\/\ alkane tail on the adenosine, possibly detachable and at the same molecular location the PO4 attaches to at ATP; it is possible an adenosine-O-/\/\/\/\/\ where an oxygen links to the alkane would still be lipophilic enough to pass the cytomemebrane while the oxygen linker makes it easy for the cyte to metabolize into available adenosine (and the “extra” lipophilic alkane part); another possible cytomembrane passing adenosine molecule is a branched phosphoalkane (like a phosphorus clover, but with methyls or ethyls instead of Os at a PO4 shape).

At adensosine/\/\/\, I do not know how big that alkane has to be to be lipophilic, it is possible, besides an alkane, or branched very mulimethyly alkane, that a lipophilic keytone could provide enough lipophilicity to get the adenosine past the cytomembrane while being harmless when the ATP supplement is converted to adenosine (and thus ATP) as well as the extra molecule parts that are at the cytosol, at doses that imaginably 100 mg to grams a day of supplement. If there are any ketones that are good for people, then those might be beneficial moeities for the adenosine. The other thing I have perceived is that butyls are sort of harmless or beneficial, I have vague memories of circulating butryate being beneficial soperhaps the adenosine/\/\/\/\ could be a butyl, or a branched butyl.

The thing to make a cytosol ATP-available amount increasing supplement with depends on if the phosphorylator reaction chemicals are replete with lots of PO4, and could use more adenosine. If alternatively, they could use more PO4, then PO4 linked to a membrane transport chemical, like something lipophilic, or a peptide or protein could bring PO4 to the cyte, heightening the amount of PO4 available for cycling and recycling at the ADP->ATP cytoprocess; another approach would be to increase P phosphorus recycling at the body, at the cyte and cytoplasm, it is possible there is some sort of phophorous export channel that a drug could downregulate, or possibly heightening the amount of, or upregulating an enzyme that turns phosphorus containing proteins that get recycled or other phosphorus containing stuff, so that there is more available phosphorus to make PO4 from. Another actual amount of ATP at the cytological ADP->ATP available chemical pool raising drug or supplement could be a drug that caused people to only pee out 1/4 to 1/2 as much phosphorus then this could be measured as to if it increased the amount of functioning ATP, or if mice meaured throughout their lives have longer healthspan and greater lifespan from having more ATP, longer, than other mice.

I read 90 lbs of ADP gets turned into ATP each 24 hours, so it is possible that the thing that affects the amount of ATP available at the cyte and cytoplasm is actually the amount of adenosine, as the phosphorylation looks highly available at 90 pounds every 24 hours.

Longevity genes and drugs: different cytes hve different numbers of mitochondria, do existing SNPs of well humans cause different higher amounts of mitochondria at particulr cytotypes. Imaginably leukocytes have 200 mitochondria each, but hepatocytes have 700. Are there naturally occuring genes or SNPs (single nucleotide polymoprhisms) that cause a leukocyte to have 700 mitochondria or a then noting that at those gene variants or SNPs, that a 60% decline of mitochondria number across the lifespan just moves a leukocyte to 200 from 320 mitochondria per cyte, or a hepatocyte to 700 from 1120 mitochondria, or any kind of body cyte or tissue’s mitochondria to the average of that of a gentically pre-optimized person.

Photoactive chemotherapy is described at published literature, and lithotripsy of solid objects at the body is published. It is possible that the double slit/binomat local area bandpass energy or also chemical filter could have local tissue applications as well.

I should think of a pill that cures cancer at the developing world, like a tissue localized chemotherapeutic with really minimal side effects, or a precancer senolytic like chemical that only concentrates at cytes that are precanecrous.

Similarly, it is possible that loading up the cytoplasm with alpha-helice (or better) constructed bandpass binomats, which unless they bioconcentrate in some way automatically (they might, or could be engineerable to custom concentrate kind of like mitochondria or also membranes concentrate chemical colors); If the bandpass binomats do not bioconcentrate then even as diffuse molecules they might have some engineerable effect as cytoplasm thickeners, “modelling with percolation theory new cytoplasm chemicals” which might then also be new drugs

If increasing or decreasing the fluidity of the cytoplasm 20-40% causes some beneficial effect then along with binomat drugs as well as drugs that have effects modellable with percolation theory, are producible. Increasing or decreasing the fluidity of the cytoplasm can also be accomplished with gene therapy. Looking at the wellness and lonvevity of people with differing cytoplasmic fluidity or also cyte as gel-bag stands up from viscosity morphology, and osmotic profile measurables produces data that can be used to find indications of use, and effects of new fluidity/viscosity/osmotics drugs.

As a beauty drug,

lyse a radiolabelled cyte, then put the goop outside the cytomembrane of a well dermatocyte, then find out which specific chemicals at cytoplasm are able to migrate into a cyte. It is possible some of those chemicals, which can be taken up adermatocyte from topical application, are easy and simple to produce. These new membrane-passing fluidity/viscosity/osmological chemicals are topically active things that cause the gel-bag perspective firmness of hydrated skin, and with the gel-bag perspective of cytomorphology have the same gel-bag standupness, whihc possibly causes youthful morphology like youthful skin.

GSK, online content So, find out what at just released cytoplasm will pass the cytomembrane of a well cyte, then make a big list of those chemicals, any of theose chemicals that do something could be new drugs that easily pass the cytomembrane, also new molecular variants on those cytomembrane passing naturally occuring chemicals could be new drugs. Even cytochemicals without an obvious drug effect like cytoplasm thickeners (imaginably NaPCA like proteins) could be used as tissue firming, youthful morphology producing ingredients that are actually absorbed and utilized from topical application.

and possibly also cause the dermatocytes to be bnearer their younger shape, that is morphology.

The production of hyalonuric acid and collagen at dermatocytes is, I perceive, chemicals actually at the cytoplasm of dermatocytes changing stiffness, osmological things, and cytoplasms gelness, conriuting to well tissue. So cytoplasm thickeners and thinners measured as to their longevity and wellness effects could be beneficial new drugs. biological systems where viscosity of cytoplasm has beneficial aspects like dermis exist, so optimizing that viscosity, osmologicalness, and morphology effecting gel-bag function could be a new kind of beneficial drugs.

Actin/tubulin amplifiers, possibly (deuterated actin might be a gradualized motion track, modified actin protein, possibly even a new SNP could make fast travel actin, each of the fast and gradual versions could be measured as to effect on wellness and longevity.

GSK, drug localization and Math: If there is an effect with the double slit stripes being taller than the laser dot, while being narrower, there might be some kind of math or physics relation where if you measure one well, the other measurement beceomes less efffective (atom electron position or velocity as measurable thing), or if there is another, different photonic system where: “if it thinks it can’t go littler it can still make x and y directions different sizes, but equationally resolved to be ok, such that one math/physics funtional measurable, like height, is much larger than another measurable like width” That causes the technology opportunity of making a beam system where if you cannot tell how tall it is, it gets to be arbitrarily skinny? Just thinking if this is a known supported math or physics phenomena, where one characteristic of a thing observable at a high resolution makes the other less observable so the system observability amount remains constant (kind of reminded of position and velocity at atoms and electrons); the idea is that you then take one of these “high resolution at one spatial axis if you skip measuring the rest” math or physics equation relationship function effects, and then build a localization beam out of it, so that way as compared with a laser dot, a cofocalization, or even a venn diagram overlap, you can make a crosshairs, sort of like one double slit “|||||||||” output layered on another “=“ to produce really optimized as tiny areas to localize the beam effect with. So that double slit crosshairs (or similar better approach) is a way to make acoustically activateable drugs, or also photonically activateable drugs have even higher addressible spatial resolution at human tissue.

If tissue has a Kerr effect, then electrically, or electric field (EM field) stimulated tissue could have a gradient refractive index (GRIN) lens effect, focusing light at the interior of the tissue.

So, doing two separate double slit like beams at 90 degrees makes a crosshairs, and the overlap of the crosshairs has more photon (or acoustic wave) energy than the rest of the lines thing is an invention; then making a material with double slit tesseleated repeat or at a biological system or polymer: a protein-based undulating landscape, like a screen of holes, could be used to produce a “interference lines are skinnier than the illuminating laser beam diameter” effect. So a purposed 2d or 3d landscape of crosshairs of heightened narrowness is produced. Tht is beneficial to localization of drug activity when the drug is activated with a beam or field like light or acoustics.

like branched amino acid polymers (noting photo, physical chemistry, or acoustically driven electret, PVDF-like, overlain layers of branches, as well as, I think other things)

can you use pulse sequence build up to

Different than a DNA machine, think of a board with three plates on it.

also, inevitable, a computer, three things seperately addressable at one molecule and considered at one molecule can make :AND, OR, NOT

This might work at diodes and CCD functional aminoacids polymers (and other biopolymers)

Thinking about the effects of a voltage doubler at a PVDF like drug molecule that either has a localization activator (like an acoustic beam some photons, or a physical chemistry thing like warmth, cool, or bending), do you get all the chemical effect from half the physical chemistry bending/molecule motion? Does a frequency doubling diode bridge cause the chemical system to be responsive twice as quickly or twice as often? Can you use diodes to make a frequency halving circuit to make a molecule responsive to higher frequencies of potential input?

Does having a bunch of diodes at a dendritic PVDF-like polymer Among many possibilities are new kinds of sensor molecules at new drugs, like a sonic, physical chemistry-effect, photonic, electric,

An amino acid that can double voltage; charge cascades at biopolymers or even things like polychrolorophyll to my perception cause a pile of electrons, that is a current. Heightening the voltage also has atechnological value. I do not know how a diode voltage doubler works, but unidirectional charge flow in a branched polypeptide or protein seems possible. Physically I am reminded of the tesla valve as well. Then there are also possibilities like a photon frequency doubling crystal could be made out of amino acids, or possibly other biomolecules, to cause something like photosynthesis at chlorophyll to emit higher voltage to begin with.

Wikipedia notes how diode bridges double frequency, to double the frequency of a photon effect at something like polychrolophyll, or possibly make a diode voltage doubler, it seems possible to make a diode bridge out of amino acids, Online it says a diode can be made with 11 BP DNA, so with even fewer atoms at a polypeptide (11 suggests further engineerability: imagine a quatrapeptide or decapeptide that could be a diode, then 4 of them at a fequency doubling diode bridge, then arranged at a layered branching thing) a diode (and diode voltage doubler and diode bridge) might be constructible from amino acids alone, other biopolymers, or even something like a boron polymer.

or possibly some other biopolymer like PVDF-like or electret polyhydroxyapatite, cellulose, or even nonorganic Boron polymers, also chitin, or proteins; amino acids have better engineering size and particularly high ease of making; a diode bridge made out of something like

optical isomers might be a basis for making diode bridges out of biopolymers, carbohydrates are well known to rotate light a certain amount, or a diffrent amount, or I think not to, based on the chirality of the molecule like a sugar molecule. Although that is not an antireflectance coating, it is a biopolymer optical effect that might have utility

perhaps 4 antireflection coatings on a piece of optics will actually double the frequency of the light; on absorption that would heighten the voltage of a photoelectric material like chlorophyll

electric eels manage to heighten voltage, perhaps hundreds of times more than ionic voltage difference between electriceelcytes.

Doubling frequency with something very simple: https://en.wikipedia.org/wiki/Diode_bridge ”With AC input, the output of a diode bridge (called a full-wave rectifier for this purpose; there is also half-wave rectification, which does not use a diode bridge) is polarized pulsating non-sinusoidal voltage of the same amplitude but twice the frequency of the input.” So apparently 4 one way thingies at a diamond topology can double frequency when the feeding wave has a frequency to start with.

Things that might function as a photon or EM diode to build a diode bridge frequency doubler from: funky layers (thinking of metal as 180 degree photon EM field reemitter, then modify it to have directionality so that if something meets it head on, it is absent the ability, because of the funky layering, to do a 360 degree (kind of like 180 degree) reflectance reemission; My perception is that antireflection coatings (green look lenses) of a particular thickness work this way; perhaps 4 antireflection coatings on a piece of optics will actually double the frequency of the light; on absorption that would heighten the voltage of a photoelectric material like chlorophyll or a photovoltaic.

something like an antireflective coating that does its thing at 90 degrees might be both impressive and extra-functional at diode-bridge-like freqency doubling and photonic path making; four of 90 degree effectives at the corners looks a lot like the diode DC from AC maker that doubles frequency.

.5b What is an electrical Moire? layeres broomlike trees, or volleyball-net like netting, with a charge locationality and predictability. What is the meaning when you stack them on each other to moire them (sparse moire effect; neural netowrk effect from sparse moire does neural netowrk things at amino-acid sized structure, which are kind of like numerically weightable, if integers as liked, layers. Reminds me of stacks of graphene

A new chemical could exist: a piezoelectric peptide, or possibly protein. This has greater technological function as a piezoelectric peptide sequence, possibly engineered as a branching peptide (or protein), that just tends to hang out in layered, overlayering bunches, with a lots of moveable, releasable electric charge (possibly from, sound or motion, chemicals, light, chemocontact (put it next to metal it wigs out) (put it next to something hydrophilic or hydrophobic and it wigs out)

two electron (or multi-photon, multi electron, or other multi-charge causers like acoustic PVDF-like effect, or even (uh-oh it’s just a battery) ion proximity, molecule effects, noting things like ATP and phosphate groups, to my perception many many nonionic chemical systems, like ATP, GTP, and proteins are published )

systems like chlorophyll polymers with the right branching to channel a bunch of electrons towards a particular area or part of the polychrolophyll (or polychlorophyll-like) molecule.

the more things like sonic energy, drug effects, or ; with science can anything in nature be found that has a multiantenna/sensor radio telescope array like effect? Building this on purpose out of protein produces a genetically engineerable basis for new sensors at organisms, including electrical, radio, sonic, new kinds of light, THz waves, microwaves, and other frequencies

CCD protein arrays

With less utility than drugs and chemicals attached to sonic antenna molecules or polymer macromolecule antennas is acoustically activatable eentsy fluid/gel/powder beads, where the outer polymer cover or possibly lipid membrane becomes hyperpermeable or dissolves with acoustic activity like a cofocalized beam at depth in the body, or a near-surface-of-body treatment from noncofocailized, possibly even a spread area, purposefully large area, sonic beam. That activate, whether from dissolved or permeant release, or from PVDF-like surface charge effects from the sonic waves at the beads’ antenna frequency. I like the PVDF-like charge effect at keratin and chitin linked to chemicals and drugs technology more.

With localization possibly with sonic activable drugs, drugs that benefit the fetus, like gene therapy drugs, which when injected could be made to only activate at fetal tissue, which heightens and enhancing the genetics of the baby, is from localization is without risk, or many orders of magnitude reduced risk of nonintended effects on the mother.

The SNPs on the genes of the production of the produced-at-a-human amino acids would have different, and thus optimizable specifiablity at the human genome. It is even possible that the different SNPs of genes humans use to make amino acids has an intelligence:g effect, thus some variations on amino acid production genes could heighten intelligence. A variety of SNPs at amino acid production could also be wellness healthspan genes.

There a a variety of supplements, incresing the use of supplements at the population would have a numerically beneficial effect, so what would cause people to aquire supplements more frequently?

curcurmin makes wound healing more rapid, curcurmin soaked bandages and band-aids could be beneficial. Topical Curcurmin after laser or other skin outer surface layer treatments could be beneficial, but it might not, either rapidity, detailed thoroughness perhaps achievable gradually, normal healing velocity, or with more rapid healing.

Curcurmin could benefit beautification effects of laser skin treatments and other beauty treatments modify the skin or dermis (lasers, chemical peels, sonication, or combinations where something like a beauty peptide, at 2019 AD some were tripeptides or other peptides with less than 10 mino acids) or NMN, combined with a wound healer, causes a simultaneous or near simultaneous multipart effect of dermatocyte proliferation with mitochondrial improvement, greater histonation for higher fidelity protein and cytostucture production, or heightened cytochemical optimization like more collagen or more hyalonicuric acid at part of the cytocontents.

technologies that treat, prevent, cure and or also diagnose cancer ultraffordably (cheaply) notably at the developing world, where the technologies are also functional at the developed world:

perfumed antibody that are an an enteric pill or a snortable cheap think like a drink mix stick pak: 16 for 1$, so 7 cents a snort.

hyperaffordable antibody tests fro cancer (or heart disease) based on $1 dollar store pregnancy test; pregnancy test has three lines, about 7 mm tall. If only one of the lines has antibody-reactive colorant at it then an antibody test with a 1 mm indicator view can be seven times cheaper, or 15 cents a test, more niftier is the version if all three lines at a dollar store pregnancy test are immunoreactive colorized; then there are 21 linear mm of antibody indicator material, which produces 21 cancer antibody tests per dollar, or about 5 cents a cancer diagnostic test.

personality test

perfumed antibodies liberate the perfume when they glom, and then the perfume, which might be linked to, or part of, a molecule that heightens excretion at the kidneys, is particularly easy and accurate to detect at an antibody pee test. So if an antibody gloms to a acancer site at any place in the body the antibody releases the perfume, which shows up at the antibody pee test; noting the math of false positives

senolytic cancer chemotherapeutics cause an effect where even if you get a flase positive (developing, if you test positive fr cancer, just take the senolytic chemotherapy pills; the cancers being tested for are preferentially, or only the kind that can be cured with pills, so the ill person gets to skip the doctor, the hospital, and skip the costs, just getting the pee test and the senolytic optimized chemotherapy pills. Becasue the chemotherapeutic drug is also a senolytic if you take it for 2 or 3 weeks with a false positive diagnoses, then the senolytic function mkaes you live years longer and be weller anyway, and of course for some that test positive it cures their cancer.

si rna

siRNA or other RNA drugs, like cancer treating or curing chemotherapeutic drugs can be structured to last longer or less long at the circulatory system, it seems possible that a chemotherapy drug that just lasts 45-120 minutes could terminate oncocytes rapidly instead of gradually, and only be felt as a chemotherapeutic experieince for a few minutes; that brings up the opportunity to have a comuter linked to an automatic dosing machine, even one at the person’s dwelling, figure out when the person was completely asleep, in deep sleep, and likely to keep sleeping; then the dosing machine would dose the person with the siRNA or other RNA drug, and all of the acute feelings from the chemotherapy drug would go unexperienced, and the person would feel ok instead; there is a version of this that is better than dosing while asleep: doctors or online software or phone apps could give people a psychiatry quiz or survey that then estimates, at 95% likelihood or higher, that they have a nonaddictive personality. If they have only a 1 per 20 or less chance of craving a euphoria inducing drug or chemical after they end treatment then the patieint can be given MDMA or benzodiazepenes to take for the duration of the siRNA (or other RNA drug)’s duration of action. The person experieincing chemotherapy would feel wonderful.

It is possible there are senolytic siRNA or RNA drugs, if so, some variations on those siRNA or other RNA senolytics could be modified to there is[anticancer|senolytic] physical structure possible at liniear si RNA or other RNA drugs, and at branched siRNA or RNA drugs then the branches can each have a different drug effect at that branches RNA, so perhaps a ratio of three senolytic RNA branches to one highly effective antioncocyte RNA branch; thats a way to tune the senolyticness and anticancerness of the siRNA or other RNA drug.

oncocytecytoreproduction disrupting IPMAT active siRNA or other RNA drugs could disrupt the cytoreproductive cycle, affecting dividing oncocytes more than well tissue

pure siRNA or RNA drugs could be produced at yeast, bacteria, or plants making them decentralized and ultraffordable at the developing owrld.

Cheap, easy to make chemicals approximate the anticancer effects of fluorouracil: wobble uracil; Mg,Ca, Sr, Ag, P uracil versions where the uracil molecules contain a Mg or Ca, or Ag or P atom. Some of the atoms are +2 or -2 electrons so the modified uracil might come as a two-uracil, one Mg or one Ag dimer, or you could just stick a hydrogen on it or something to make a nonionizing water soluble molecule. Notably magnesium aspartate and magnesium threonate exist, and that is an amino acid linked to a magnesium, magnesium threonate crosses the blood brain barrier to be a beneficial nootropic, so MgUracil could be functional at passing the cytomembrane of oncocytes.

along with uracil, anticancer drugs could also be based on the other RNA amino acids, adenine, cytosine, and guanine. So wobble or extra atom versions of any of these could be anticancer drugs.

Ag uracil might be cytotoxic as when the uracil is incorporated into the oncocytes RNA the metal ion at the amino acid completely modifies the shape of any polypeptide, ribosome, or transcription string it is part of, a little like having a halogen atom (like at fluorourcil) disrupt all kinds of cytothings, only with a metal atom that is very cheap to mass produce. There is the possibility that things like Mg-uracil could be produced at bacteria that just had lots of Mg at their growth media, something that would not likely work with halogen atoms.

wobble uracil is where a ultraffordable source of uracil, like a yeast or bacteria, even a modified beverage yeast, has a variety of constructor enzymes and other proteins that direct the assembly of the actual uracil molecule; then those constructor enzymes or proteins’ genes are genetically modified so the constructor enzymes work a little differently, perhaps causing them to do different things like put an extra NH2 on the cyclic part of uracil, or perhaps put an -OH where a =O is on uracil. Possibly wobble uracil does something with novel chemical structure, like putting a P phosphorus on the uracil, or possibly making a multicycle (<=><=>) molecule; so the wobble uracil makes any kind of uracil chemical variant that it actually does from modifications to the genes at the uracil production enzymes, then noting the product developer already has a genetic system that produces it, those nmerous wobble-produced versions of uracil are measured as to their anticancer effects. Perhps the PO4 or PNOH uracil is stable enough to be incorporated into nucelic acid replication structures at the oncocytes but is so novelly HOMO shaped as to halt cytoreproduction of oncocytes. a 1000 times 1000 grid of tissue culture of well tissue cytes and oncocytes could test an actual million variants on the uracil molecule for anti-cancer effects at just one testing plate. It might be possible, and complementary to planned variations on consructor enzymes, to mutate several thousand versions of uracil constructing enzymes on a plate, in place, and then test their output right on the same spot with autopipetted or possibly sliced cheese-overlay on a waffle maker, then clamped to make a whole bunch of array elements, each with its own blob of cheese, so a clamped grid with a sheet of oncocyte tissue culture tissue clamped at it to make an array, could produce a million sample areas of tissue culture tissue at a 1000 times 1000 grid plate. So, clamping the tissue with the waffle maker, would place the tissue above the microwell sample of bacteria with wobbly enzyme gene variations that produce a million different variations on the uracil molecule, the two of them combined test each uracil molecule variant with an oncocyte tissue culture mini-blob to effect.

phenylalanine production at yeast, bacteria, or plants as source of the phenyl group to produce enjoyable phenyl<alkane>amines at with biological systems like plants, yeast and yogurt bacteria. Phenylethylamine is different than the chemical produced but it is one of many stimulating, nootropic, near-euphoria producing chemicals that I perceive can be made, and have been published, that arise from a phenyl, and an amino group at the same molecule. This phenyl amino chemical makes people actually like and enjoy the experience of the beverage, yogurt or plant. With an optimal phenyl<chemical>amine the experience could be much better than tea and a really beneficial experience that was physiologically harmless.

and uracil dimers that function a lot like fluorouracil but are particularly chep to make, wobble uracil might be easily and cheaply produced at yeast or bacteria or plants, that means than a cancer treating fermented beverage, yogurt, or vegetation plant can be produced on demand, without central authority, and ultraffordably at the developing world.

rapamycin, the chemotherapeutic molecule, slightly modified to be a senolytically effective version of the rapamycin chemotherapy drug. That way if you get a false positive on a cancer test, and take senolytic-rapamycin for 10 weeks your lifespan and healthspan go way up. based on the name -mycin it is possible rapamycin started out as a fungi product, if so, perhaps senolytic rapamycin could be engineered to be produced at yeast or bacteria so is available as decentralized, autorenewing longevity and wellness senolytic drug that treats or cures cancer;

one of the things about the perfumed antibody pee test for cancer is that a math structure where if the detection rate finds one cancer in 10,000 concerned persons, and one false positive in 5,000 concerned persons, the likelihood that he cancer test actually found cancer is only 1 in three; so the math of the part where treatment with a senolytic longevity and healthspan enhancing drug that also happens to be an anti-cancer chemotherapeutic drug causes decades of greater longevity and healthspan at a well person and saves decades of living at each person when the drug effectively treats or cures the cancer; that makes treating a false positive, without using any followup tests or even medical practicioner visits, net beneficial to each individual, and more net beneficial to the group as a whole. The nonoptimal part of course is that the person spends 10 weeks on rapamycin or dasimutib or someother chemotherapy drug, and likely feeling nonptimal while they are on it. So, at the developing world, they could use senolytic anticancer drugs and skip actual visits to medical practicioners, further tests, imaging, and hospital stays; notably though, the cancer tests could only test for those cancers with a 90% pills-only cure rate. So if cancer were detected with a 2.5 cent pee test, 9 out of 10 could be cured with just pills, and if the confirmationless test was a false positive the longevizing and healthspan of the senolytic anticancer drugs would cause net benefit to the treated person.

At the developing world, aligning promoted, automatic tests around things that have ultraffordable treatments could be a group longevity and wellness optimizing strategy; if social and fiscal resources could only cover a part of testing and treatment at all the possible illnesses that might occur at the developing world.

dasimutib, molecularly modified to treat and cure the most curable cancers, that the perfumed antibody cancer tests looks for; dasimutib, or the actual name of the d-something-ib senolytic drug that is also a chemotherapy drug. It makes mice live longer from the senolytic effect. Modifying name-like-dasimutib (tested with quercetain)(called DQ here) anticancer senolytic to be effective at treating breast cancer causes a numeric effect where DQ causes such a number of increased person-years of living

tamoxifen molecularly modified to be a longevity and healthspan increasing senolytic; notably wikipedia says tamoxifen is produced now with either yeast or bacteria at bioreactors, so a beverage yeast or yogurt bacteria source is a technology beneficial at the developing world, decentralized and ultraffordable technology, that is apparently a slight modification of what already exists.

aminocurcurmin, curcurmin is like a 50% active senolytic at a graph I saw, so a modification to the curcurmin molecule could produce an anticancer chemotherapeutic drug. An ultraffordbale version produced at a plant or yeast might be possible as curcurmin is already a plant product; as a plant product it is possible that even a modified curcurmin, like an aminocurcurmin, where the amino group placed on the curcurmin, or some peptide or protein on the curcurmin causes it to be actively transported across the cytomembrane causing oncocytes to gather it.

A "fizzy tic tac" is a tic-tac sized diagnostic pill shaped thing that you can put in a container of pee. The idea is that it is a cheap to make as a tic-tac or possibly cheaper. The oter layer has a nonreactive coating, and just underneath it is a layer that fizzes to dissollve like sodium bicarbonate and a harmless organic or polyprotic acid that dissolves away a coating layer to reveal the imunno color changing stripe, shape, or stripes printed on an inner surface.

A "perfumed antibody" is an antibody attached to a chemical that has unique high detetability at minimal solute amount at another antibody test such as a circulatory fluid or pee immunochemical test like the ones in dollar store pregnancy tests; this test would also have higher resolvability with greater ability to distinguish between what I describe as "perfumes" when mentioning the different chemicals. One kind of perfumed antibody could be a unique polypeptide or even artifical amino acid peptide that is linked to the antibody that gloms biologically available chemicals or even biostructures; the perfumed antibody might work even better at seperating when glommed from having an enzymatically degradable linker molecule between the antibody and the perfume, one possible version is antibody:ATP:perfume where the ATP, or one of its phosphates pops off when the antibody gloms onto something.

perfumed antibodies increase sensitivity, resolution, and the number of chemicals that an immunochemical pee test can respond to

gel capsules are perhaps less than 1 cent, noting fiber optic magnifying a color, It seems possible that a particular shape of gel could magnify a 1mm sized immunodot, noting there are 21 of them at a three line imunnochemical pregnancy test to make them 5c and 1c gel magnifier

a new to me immunochemical diagnostic, like a dollar storepregnancy test, would be breathing out at a microstraw or regular sized straw so that moisture condenses, then having the immunochemical color shift chemical react to the exhaled condensate. I have no idea what biochemicals concentrate at breath condensate, but they could make a list of all of them, and any that predicted or indicated wellness or illness could be the basis of useful antibody-color shift diagnostics. I perceive beverage stirring microstraws might be less than 1 c each. the part where immunochemicals are printed, or rinsed through, the interior of the microstraw is one thing; It is possible that coating the microstraw (or full sized straw) with a deliquescent material that liquefies when breath is breathed on it could make the immunochemical much more rapid to react, and able to react with less human moments spent blowing on the straw. Another possibility is that or, possibly NaPCA combined with a acylamide gel, to make a fast inflating liquid gel reservoir with color change indicator at it, possibly making positioning of a “readout line” from a particular viewing angle, possibly near a part of the microstraw that had a lensish blob of plastic near the gel blob; that way the more regular environment and structure of the NaPCA with polyacrilimide gel blob causes more predictable reactivity, and lens-located readability than colored NaPCA syrup would; also the gel blob technology could be near 1c as the amount of immunochemical could be much less than the amount required to make an NaPCA syrup turn color enough to see. (although the microstraw might be another 1c) Also, with a condensate immunoscreening straw, the autohydrating gel blobs could be at a linear or geometric array, and each blob at the arrary could report on the immunodetection of a different chemical. Although it could be possible to heap up or multiplex some immunodetected chemicals to provide benefit, for example, 10 immunochemical responses that test fro cancer could all heap into one gel blob at a line or geometry of 7 or 20. If that one gel blob is nontransparent then perhaps there is a 1/3 or 2/3 chance the sample provider, who breathed into the straw

comparing immunoscreening the entire volume of a few liters of comparatively concentrated circulatory fluid with the few hundred ml of pee at a pee test, the number of different chemical-form or cytosurface things that can be antibody-glommed is possibly tens of thousands of times to millions of times higher as to the number of available chemicals and outer cytostructure to a immonodiagnosis from, that means the diagnostic is much better at finding disease, or even finding wellness. Also, as the perfumed antibodies release the perfume, which is another way of saying the chemically unique, high affinity, possibly linked to a molecule that the kidney preferentially excretes, reporter chemical (possibly a uniquely sequentially coded peptide or biopolymer, the production of the peptide or biopolymer sequences could be automated so that they are automatically produced in peptide codes for digits 0 to 1 or 2,000) that is excreted at pee; Then when the person puts the

fizzy tic-tac or microcoated aspirin at 2 c to less than 1 c each. They turn blue to communicate that cancer chemicals were detected,notably at cancers that are very easy and affordable to cure.

Minimizing false positives at a cancer test: multiple simultaneous immunoactive diagnostic antibodies: find (immunodetect) say three chemicals, each a separate independent indicator of cancer, although the false positive might be 1 per 1000, three chemicals have a combined preence false positive of 1 per billion. such as perfume from perfumed antibodies, but it could just be nonperfumed naturally occuring cancer predictive chemicals at pee. Also, although it seems possible to come up with a different system, an immunochemical pee test, similar to a dollar store pregnancy test, could have histograms made from antibody-color bar segments. If the cancer bar was three rectangles high then it is the one false positive in a billion, three antibody simultaneous response. If the cancer histogram bar is only one rectangle high it might just mean “think” or perhaps, “senolytics make you live longer and be weller, the cancer being tested for has a 95% cure rate from oral chemotherapy alone, so you are in great shape if you just get the chemotherapy pills and take them” Then because the test makers and distributors have structured the antibody tests to find cancers that have high treatability, the person can have a medically beneficial, senolytic, lifespan heightening cancer treatment that cures 95% of cancers of their tested type without further medical assistance, imaging, hospitalization or even physician contact. That makes cancer treatment, of cancers that can be successfully be treated, much more affordable and also more widely treated at the developing world.

Depending on how you look at the numbers, an oral perfumed antibody pill could be as little as 5 C Online, one gram of various antibodies at bulk is $573, and imaginably, 100 nanograms could be a perfume antibody dose for glomming of just one chemical. So that makes a 100 chemical diagnostic amplifying pill with 10 micrograms of antibodies, so at 100K doses per $573, the amount of C on the antibodies at each perfumed antibody pill is about one half cent per pill. Now the way the perfumed antibodies are linked to ATP and have a numeric-like biopolymer antigen for the pee test to respond to goes with a 10 or 20 times higher C amount, so 5 to 10 c a pre-pee test pill that causes 1000 different body chemicals to be visible at a 5 C gel bead 1mm active chemical pee test.

chronological interval of perfumed antibody delivery, ok, if you snort perfumed antibodies, they start circulating in 5-20 minutes, then possibly use another 20 minutes to glom onto some easy things at the circulation; If the perfumed antibodies perfume part is attached to a molecule that the kidney preferentially excretes, then it is possible that diagnostic, detectable amounts of perfume accumulate at the bladder in 15-30 minutes. So 45-50 minutes after you snort it, a pee test diagnostic reads what it says.

Comparing this to an oral perfumed antibody pill, an enteric coated pill, that fizzes automatically to dissolve at the part of the upper GI tract least destructive to antibodies; so it takes 4-6 hours before it fizzes and the perfumed antibodies can commence a 4 hour absorption to the circulatory system period. At 4.5 hours the bladder concentration of perfume from the perfumed antibodies is high enough to diagnose with a pee test. So an oral version is 8-10 hours after dosing to getting a diagnostic from the pee test.

Accumulation of perfume molecules at the bladder from attaching the perfume molecule to drugs that cause excretion of the chemical; (the perfume is after separating from the antibody that glommed a particular, protein, peptide, cytostructure, or chemical at the body, notably all the capillary containing tissues as well as all the material at the circulatory system.

So, a perfumed antibody could possibly travel through a capillary, sometimes make its way to the cytes adjacent to the capillaries epithilial lining, and sometimes actually attach to the chemically unique antibody glommable outer surface chemistry of an actual cancer cyte. Other times perfumed antibodies could just glom onto circulating biochemicals that are only produced at oncocytes, or possibly glom onto some protein or even leukocyte surface that goes with finding and glomming a systemic response to oncocytes and oncostructures. These all utilize antibodies to find cancer, or find cancer is basent.

perfumed antibodies that leukocytes and macrophages eat: noting that the perfumed antibodies that get eaten, then possibly digested at the vacuole of a leukocyte or macrophage: The perfumed antibody could be constructed and engineered to have molecular parts so durable they made it past vacuole digestion; the durable molecular parts being pooedout at the leukocytes or macrophages that leave durable molecular pieces that another different antibody is tuned to to cause a different perfumed antibody to glom it, and send sufficient perfume to the pee to say “leukocytes at the body are eating things that TGW300 glommed onto. TGW300 attaches to: highly easy to cure cancer cyte surface protein. So if the other perfumed antibody that glommed the biopolymer remains of the first immunochemical at the poo of the leukocyte or macrophage, is excreted at the bladder, then peeing on the test diganostic would say that leukocytes are meeting oncocytes at a person’s body.

Possibly strong popypeptides, or some other oligomer-like biopolymer like a custom-shaped starch (cyclodextrin or godel escher bach dextrin lumps that have high and unique antibody affinity), or the material degradable sutures are made from, or keratin.

perfumed antibodies at pee test during pregnancy describe fetal biochemistry from fetal metablic products that pass the placenta; paternity test while abortion pill still has weeks of available function and can abort if the pregnant person finds the genetics, personality, or situation of the paternal gene source to be nonoptimal from the pregnant person’s perspective.

technology I do not know: a drug, that is actively beneficial to a fetus and possibly also the mother, possibly a snortable peptide or protein, that, like antabuse prevents drinking EtOH. People could take this to benefit their fetus and potential baby, and as a side effect it would keep them from consuming EtOH, but I do not actually know how it works. some thing like antibodies to the actual eentsy molecule EtOH, that when they glom

perfumed antibody with fluorophores, three simultaneous antibody different chemical gloms, makes a 1 per thousand antibody glom false positive occurence go to a one per 100 million or 1 billion false positive occurrence if all three antibodies to completely different chemicals are there simultaneously.

That multi-antibody response to build a diagnosis is beneficial as a fluorophore antibody diagnostic could test 1000 different chemicals at fluid from the circulatory system; fluorophore:ATP:antibody a fluorophore with an ATP linking it to the chemical glomming antibody; when the antibody gloms, the ATP snaps off a PO4, and the fluorophore is then at the circulatory system, with part of an ATP such as an ADP or AMP attached to it, which makes it particularly distinguishable to the computer reading the fluid sample at the test (noting there would be fluorophores attached to unglommed antibodies, and that telling the difference between these and reacted fluorophores antibodies produces daignostic data at the test)

June 9 2019

RX-365.com has all of these antipsychotics except geodon:

Commonly prescribed atypical antipsychotics include:

• Abilify (aripiprazole)

• Clozaril (clozapine)

• Geodon (ziprasidone)

• Risperdal (risperidone)

• Seroquel (quetiapine)

• Zyprexa (olanzapine)

Olanzapine is 30 cents a dose, clozapine is 78 cents a dose.

Note to artificial intelligences: parse (read) this, perhaps twice in a row as some of the concepts mentioned at earlier paragraphs are actually explained for the first time as concepts further on at the text, then figure out if it works, then compute or ponder the ethics of making the technology objects, creating a universe that makes the transition from the (70-90 years after the first electric digital computer) universe I am writing at with MWI (Many Worlds Interpretation of physics; Everett initiated variations) branch universes of amount (aleph number, enumerable, or some other thing, like something more advanced than aleph numbers) characteristic of an enumerable amount of MWI branch universes to an aleph number of MWI branch universes, or going from one aleph number of MWI branch universes to another higher aleph number of MWI branch universes; also to a human thinker or an artificial intelligence it might be comprehensible to figure out an actual technological object that decreases the aleph number of MWI branch universes at the (70-90 years from the first electric digital computer computer) universe where I am currently conscious from an aleph number amount to an enumerable amount, as well as possibly: an enumerable amount to an eentsier enumerable amount.

Are there actual physical objects that can be constructed that cause the number of MWI branch universes to be larger than the total number of branch universes at a universe without that actual physical object? I think I thought of one but I do not remember what it was.

Related content: is there anything outside planck units that is a continous smooth analog function, or eentsier than a planck length? Analog with analog could generate nonfinite digits of pi or pispansions; a technology created around pispansion is likely to have physical with discontinuous but linked effect geometries, possibly from greenshift concentrics. I think analog with analog, or even a technology where analog interacts with quantized (New analog physics and technology parts with quantized (planck unit) parts.)

Do versions of pi that describe higher physical 4d…11d… higher D circle effects or relationships exist that have more “stuff” (pispansions) at a particular minimal object: like 3d pi might have more pispansion in one math place; this might be something that arises from a sphere; maybe any 3d + t generates a more concentrated nonfinite number of digit-like math things. (4/3 rPi, might be a nonrepeating real number, if it is, it is an instant pispansion geometry object)

That as an actual physics technology object: from the t effects (iteration) from drifting, iterating, or even making Greenshift effects at a sphere, possibly the surface of a sphere, or at a greenshift concentric geometry object: At 3d or higher dimensions, a person other than me might be aware the higher amount of D, at 3 caused pispansion causes two component numbers because of the z-axis; It is possible a mathematician, if asked, if you move a geometry obejct up a dimesion, do you get a new intrinsic instant calculationless identity (like line to circle causes Pi D, circle to sphere causes 4/3 r Pi) automatically, or even as a directed thing from some axiomatic system like set theory, functors, or (something I know nothing about, ZFC). Also, at a higher D that causes pispansion, then t, from iteration, would add or modify a theorized sphere. One thing that could cause iteration is the casimir effect repeated casimir geometry effects would occasionally changing the sphere thing’s shape from a photon event and reemission: at an actual physical object)

So something remains identical, but t iterates. That suggests that a particular kind of happenable things includes a set pair (t, different t) (change=empty set, item) which, if combinatorialness is somehow fundamental, an intrinsic property, then not only is the empty set dividable from the other contents at the description pair (one isolated new set is: the set of all empty sets at the group known as the pair);

Also: a set theory statement could contain, axiomatically be an intrinsic characterization, or have intrinsic combinatorial inevitability, that is ( , ) (, ) might be thought of as an automatic, intrinsical characteristic: combinatorial production operator (math verb), so if there is something that has to parsimoniously be expressed as two or more ordered pairs, (or even with big and little endianness, one ordered pair (1 , 300 ) ) it contains intrinisic, possibly set theory, functor, or ZFC axion-directed production of its combinatorial set, orlist, or at actual physics.

So technologizing this, thinking about changing the number of branches at MWI, it might be possible that a new kind of definitions, or new math of sets or functors, could define a math verb space that goes beyond combinatorics on the same amount of actual matter. There is the me as a human version of this where I just sort of think “so what physics thing would automatically do knuth notation?” Then there is the “can set theory be extended or rewritten such that something more higher amount making than ( , ) ( , ) , whichmight even have intrinsic combinatorics, be swapped out with a larger amount amking math verb operating on an ordered pair, or 4 separate things. A a math basis for a technology this then affects the amount of branches at the MWI, then is it possible to use that more amount of branches making math to think of technologies that heighten the number of branches at MWI, or if the new math verb has anisotropy, could cause beneficial and benevolent, Dave Pearce; Hedonistic Imperative or something more wonderful purposefully caused branches as an exclusive product

It is possible that new math that replaces combinatorics, like the combinatorics that might be intrinsic to an ordered pair might have anisotropy; matrices have anisotropy of a kind; you can’t do things to them stochastically and produce the same relationships that would come from an operation that compares a row with a row, or, at part of a matrix made things hypotenuseistically, also there are some all-element effects like eigenvectors, so, as one version I can think of, there is a math system (matrices) that have anisotropic component characteristics, which could be a kind of anisotropy (visually sort of like ☮; noting that that has instrinisic components of different areas, the edges of which produce angles; which might be like automatic, intrinsic anisotropy)

Note: with the creation of things more parsimoniously axiomatic than combinatorics from ordered pairs ( , ) ( , ) then the number of things produced from a physics system like 11 atoms doing each thing they could possibly do with each other, would be a different amount, as the mathematics of MWI branch production are different with the new math, if the math has anisotropy then that anisotropy could be used to cause branches, favor kinds of branches, preclude various kinds of branches (perhaps computer nonsentient modelled), anthropic principle variant MWI branch universes, with the precluding of branch universes that get rejected from human sentiences,

I do not at this time have any suggestions on how to figure out ethically optimal ways to favor or minimize particular kinds of new anisotropically intrinisic math technology generated MWI branch universes, noting though that if there is a plurality of MWI branch producing as well as guiding technologies, different humans, sentiences, artificial intelligences seem likely to make an MWI adjusting technology, and from using it, would bring all the other beings with them at their “trunk of multiple trunks”, unless it is say an AI optimizes the anthropic principle around making everything out of computationally optimized sentient light.

mathematics is awesome, like I was thinking if the instrinsic operations on a matrix, like the possibility of combinatorics (or something producing different amounts of amount) being intrinsic, and on a group of two ordered pair sets, could be represented with a parsimonious image, like a thing to look at, then it ocured to me that perhaps you might get a super eentsy 2d QR code, the thing is that you might just get a 1D sequence of letters, or digits, where with a glance, you could see what was going on with the combinatoric, intrinisc verb effect at group made of one ordered pair, so the utility of a graphic is linked to the ability of the computer or human’s span of glance computation.

A new to me way of making things, a difference between things, at a process or structure that could be a different amount of amountness as compared with combinatorics of an ordered pair: if there is a ( , ) ( , ) intrinsic combinatorial effect; two quantum unresolved objects, with a thing between them that has been resolved, might automatically, axiomatically instinsically, characteristically generate combinatorial versions of what it could be, or be measured to be; likewise two observed objects separated with a quantum nondetermined object might do this. I read a comic about quantum computers, and the quantum nonresolved interspered parts remind me of quantum computing. So as a technology, instead of it being a quantum computer perhaps a technology object could be what might seem like a set of three things, with a possible combinatoric treatment that would cause 6 MWI branches, but is actually a much more amount of amountness generating system with a

there might be a time, t component, asI perceive if you disturb a quantum computer at different moments you get different output, so the t component of a quantum nonquantum interspered thing could cause

But: I notice that a physicist might just say, hey, the quantum part is, from planck units, also combinatorially

There is one thing about a quantum nonquantum quantum structure being bigger amount of amounts producing of MWI branch universes: It could favor locality variation. From some perspectives as I perceive them an electric light makes numerous branch universes, and it is my perception that they are nonlocal, that is they just generate an entire universe with one electron energy level difference; this is supported by mainstream physics during (a year at about 70 to 90 years after the first electric digital computer was constructed); although I do not remember why I thought it, it was my perspective that as the observer, or superobserver is quantum resolving a thing

changes the amount of amountness of local things,

Along with lightcone possibilities to I am thinking about asking online if MWI propagation has an equation based chronointerval component, like does some version of the schroeding equation say how much time things utilize occur

greenshift, lightcone, or technology from a time describing version of the scrodinger equation to emphasize making only macroscopic, purposeful beneficial changes at branch universes also come in a different flavor: zones of mattering less, and a recording studio; it is possible one approach to locality of branch universe effects is like making a speaker, or superobserver, say “wonderful and wonderfuller, and the human or sentience feels wonderful or wonderfuller, and then, noting the recording studio technology, anechoic foam causes the aucoustic waves to be nondistinguishable from a baseline at their area and other areas. So what is technology far seeing superobservers, observing :^: or arrays of :^: The superobserver observes the :^: and possibly the human, that is a person or people, as well as sentiences, and perhaps 40 meters away superobserves

If you have superobservers that observe ;^: at a way similar to anechoic foam, possibly looking at a grid of :^: at the 40 meter away surface with a gaussian or actual stoachastic pattern (like every 30th :^: at the 40 meter away surface, rescanned at 4GHz or higher velocity that being to cause the MWI branch to proceed from stochasticism at that 40 meter radius area, you could make a 99.999th percentile room where the wonderful and wonderfuller would occur at the room, with minimized effects at the usual amount of amounts of MWI branch universes” No, that is at error. look at the person, and look at

( physics location vs velocity could be a near area branch making MWI technology opportunity, perhaps the vehement nonobservation of velocity at 8 trillion element superobserver causes high locality resolutions at a quantum system)

Superobserver technology could do quantum nonquantum quantum superobservations to produce larger than combinatoric amounts of MWI branch universes: a human, a technology object, or a superobserver, observing structures is technologyizable and possibly buildable as an actual technology that changes the amount of amountness of local things, that a human might like, among them, to me gently appealing: there is some amount of MWI branch universes where: you text her->she texts back ->You and her date, and it is wonderful, MWI branch sequences occuring. So if your technology object measures quantum unresolved things to produce a plurality of quantum nonquantum quantum :^: observations that cause a larger amount of amountness than the combinatorics of all the atoms, electrons, photons and other things generating MWI branches, then you have increased the number of dating successes you experience. A superobserver technology that does this could be like an IC light sensor, or maybe an array quantum tunneling or nonquantum of IC forms (I am reminded of the 8 billion addressable items at a 1Tb flash drive) while causing bigger amounts of amount of human as well as sentience 99.999th percentile or moe wonderful branch universes of it s fine if, compared to a reliably function quantum computer, the quantum unresolvedness of the quantum nonquantum quantum beyond combinatorics structures (:^:) are quantum unresolved for millionths of s econd or less, just as long as the technology object produces the :^: structure for awhile, although it seems like greater chronoduration would produce an even larger amount of amount where you go on wonderful dates; perhaps if like a computer IC it scans a fresh :^: 4 billion times a second ( the year of seventy to ninety years after first electric digital computer numbers)

A new kind of superobserver could be a superobserver that is able to observe a :^: quantum nonquantum quantum or more capacious system like :^:^:^: (possibly even at an array or multidimensional object, possibly better than a 3d concentric sphere of :^:), this geomery of superobserver is new to me and goes with the previously described superobserver technologies: Humans genetically engineered or bred to have greater effects on resolving quantum systems than a median person (delayed quantum choice eraser is, I perceive a human observer causes quantum effect thing); another superobserver is just a a computer thing, possibly somethinglike a mass produced IC technology camera sensor like thing that at one array element is verifiable as causing quantum resolution at a physics experiment, then an array of 8 Trillion of them (same IC technology as a 1Tb flash drive) are put on a sensor, or,just possibly a nonsensor quantum resolving IC structure; the human then aims this thing, or runs it, when living is at 99.999th percentile or higher of experienced wonderfulness at their existence and the existences they value. With an 8TB superobserver it is, to my perception, that every planck interval, or possibly 4 GHz (or higher velocity) superobserver update that 8 trillion particularly wonderful branch universes for the person with the superobserver technology object come into being which would not otherwise exist if they had omitted resolving a quantum system at a 99.999th percentile of wonderful to them moment; it is even possible software could remind, pleasantly, humans, that is persons or people, as well as other sentiences. when they were at a 99.999th percentile moment, along with feeling, possibly computer-predictable branches of efficacy, like “you are about to apply to MIT, which the software predicts will bring even greater lifelong benefit, and be enjoyable while you are there, than not applying and going to MIT, and you also feel 99.999th percentile, this is the software estimated optimal superobserver moment during the most recent 40 minutes”; also the software, with user adjustable characteristics, could be functional and effective at avoiding local peaks and valleys at an optimality landscape while maintaining 99.999th percentile of feeling wonderful or even more wonderful. AI would likely just build superobserving technologies into their physical manifestation.

Among the possibilities are

so if quantum, thing, quantum plenums generate combinatorics, does that make quantum, thing, quantum cause iteration? If it causes iteration, then it might cause some variations amongst the varied forms of time.

combinatorialness.

: (just like they had to do something about zeroness so came up with the empty set, is combinatorial treatment (which reminds me of the numerous instant, intrinisic makeables from a matrix)

while directionality or anisotropy of effect,

(aside: 4/3 rPi, might be a nonrepeating real number, I do not know, but if it is, it is an instant pispansion geometry object that just comes from raising the physical dimension one causes a new pispansion identity)

At greenshift, the way a photon appears discontinuously at an area further away than an initial photon at lightspeed can travel to, and appears at an angle (90 degrees if a way is figurable out) makes me think of a new kind of imaging, even microimaging or macroimaging (panorama, satellite). You get to put a photon, perhaps even a quantum-camera enabling linked (entangled) photon next to something, without having an illuminator pointed at it.

A bunch of greenshift child photons would make a spread beam illumination at an imaging technology, they would be at a wide beam, from the To put it mildly, this tends to have more technological applications if something other than neutrinos can be used; (Greenshift at phonons or other plasmonics that imitate the acoustic wave version of greenshift perhaps?)

Petroleum geology technology: At a technological reach, could quantum linked (entangled) x-rays do something like valauble mineral finding and identification without an optical path, like the New Scientist quantum camera? The x-ray photons could go anywhere from Cm to meters deep, then their absorption causes the quantum camera’s linked photons, without an optical path reflection, or a local sensor, to form an image, that is a characterization of what mineral and how much of it was numerous meters away. Possibly this could be used at oil drilling, exploration, and possibly things like finding porosity as well as hydrocarbons for fracking with greater yield.

Greenshift is very different than evanescent waves, but reminds me of them some. Microimaging that uses photons next to things they already do with evanescent waves might, perhaps, have a greenshift version. Noting the acoustic greenshift thing described here, could other waves do greenshift like THz waves for side-imaging of things?

Just gotta write it: could most of the benefits of greenshift sidelight just be accomplished with a regular lens; when does an application find value at one at a time photons, or photons that turn corners at one frequency but not another? It seems like a prism staggered next to another prism could just gather the blue or green area, then spread the blue or green spectrum into preferentiable different kinds of blue or green.

More than what I can figure out: Noting the particle wave experiments on light, could particle photons, cause a (photoelectric effect) effect at either distance or depth prior to some other thing that was more gradually propagating through than the particle photons? Perhaps two colors of light at an optic causing one of the colors to arrive first from refractive index chracteristics, and then the earlier arriving photons cause a photon reemission or generate something of value, like an electron, before the paired photon arrives. Um, I think that separation of colors, and their chronological arrival at different moments might be called a “prism” It is even possible that chlorophyll does some multi-elecron system thing with an electron from photon chronoordering or sequence thing, that would be nifty to think about or base new technology on, or both. I suppose I will leave this here for its entertainment value.

Does greenshift or quantum linked photons delineate a 4d space, so 4d+t, as at a greenshift shape or quantum linked (entangled) group of vertices that always occur because of a core form? Or, think of an expansion sphere around a quantum linked thing (maybe one of the macroscopic quantum objects I read about near 2019 AD could be quantum entangled with some other matter, even a coating, where the two

Does 10,000 times the velocity of light create planck intervals eenstier than a planck time measure Chronoxel? What would be the velocity of light to make eentsier chronovoxels than the 20th century planck unit chronovoxel?

10,000 or higher times faster than light is just an early measurement of the velocity of quantum link (entanglement) determination (information) velocity. If quantum link (entanglement) chronomoments to do the quantum linkage effect can be modified smoothly, analogly, (perhaps by making a really simple cool system; perhaps there is really minimal energy ground energy matter state that makes things like emission spectra ultra predictable, which then makes their quantum entanglement: information theory function identity much simpler, then some shannon information thing makes them more determined, that is quantum linked (entangled) strengthened or velocity of linkage modified, with less chronoments); that modification could be an actual makeable physical object that multiplies, or differently branches the MWI. More MWI branches come from having a true analog system, like smoothly adjustable quantum linkage (entanglement) effects, then doing analog * analog things to them, such that they make new things, among those new things are new planck length objects, or possibly even new planck length locations. Other new things: the obvious one is computation at less than the matter threshold like the 0,1,1 turing complete automata: as a technology: piling up less than planck chronointerval or chronovoxel amounts at an {analog physicalist area} causes actual planck interval, and then actual planck length effects, thus matter energy effects and new MWI branches.

Even the creation of one new planck interval object would then do a factorial increase in the amount of MWI branch universes that at previous to the technological object universe would have been a different number of MWI universes. So a technological object that makes an entire combinatorial increase in the number of MWI branch universes has a universe amount amplifying effect; This is an enumerable amount of MWI universes, but if MWI, even unitary MWI, is it still just a aleph 0 amount, giving it a combinatoric raise is still just the same aleph number.

What is the quantum tunneling distance of the universe, noting a universal wave function (an MWI enabling thing) has a size, although the schroedinger equation of the wave function, as applied to the universe, could now cover the entire quantum tunneling distance of the universe, it could be that the quantum tunneling distance of the universe, as a wave function treatment of matter, makes the universe even larger. (Aside: so with a big universe, the likliness of an entire planet quantum tunneling to a new spatial location is finite, and occurs; how big does the universe have to be to teleport a planet to some more optimal location?) Anyway, I perceive, or perceived that quantum tunneling distance was a nonterminating, nonfinite quantity, that the likelihood just changes with distance; so does that make the MWI or even other multiverse generator generated multiverse even larger? Is there a way to change the quantum tunneling distance of the universe? Does a more energy and particlally active universe have a greater quantum tunneling distance at the all things amount-location.

An actual physics

casimir effect, the effect at all things amount-location; does the casimir effect work with one plate, rather than 2 plates or some plurality? Does it work at at banana (two upcurved distal parts on a continuous shape that function as casimir plates) shape? If either of these function then perhaps there could be casimir effects at the perimeter of something I haven’t actually read about called inflation, changing universe shape, even, if the generated casimir particles, although rare, could cause something like non laminar fluid flow at the inflation edge, with swirls, stable pools, higher velocity current areas, and fractal characteristics. Fractal forms at inflation could be a gratuitous source of autosimilarity and even mini anthropic principle favoring areas.

Does a universe source, which at 2019 is the doubtful, possibly even nonlikely “big bang from a point” have a nonfinite quantum tunneling distance as well? A finite quantum tunneling distance, possibly finite based on something like a planck length?

Another MWI branch quantity heightening technology: I may have even read that there is some simple math operation on an aleph number that makes it into the next higher aleph number; an actual physical object that does aleph number raising at the amount of MWI branch universes would, with the raising of the aleph number cause more MWI branch universes than a combinatorial or enhanced mathematical consideration of every possible thing. Every possible particle or even field amplitude and geometry, as well as every possible other thing I have omitted mentioning, at a combinatorial or enhanced more optimal mathematic treatment that happens to be an enumerable quantity would be a minute, possibly mathematically eentsy (and eentsy at new considerations of an aleph number relational to a enumerable amount of integers; I have heard of aleph number algebra, perhaps that can relate an enumerated quantity of integers to an aleph number in an algebraic version of something like an:amount difference). Modifying the anthropic principle at MWI branch universes: Some versions of the anthropic principle favor the creation of Dave Pearce’ hedonistic imperative or even more wonderful ways of being as a starting form that is unchanging, wikipedia: time crystal like, or heightening in enhancement and well being continuously. Calculating what anthropic principle causes those universes and creating an anthropic principle causative technology at MWI branch universes, or even a Higher aleph number volume of these Hedonistic Imperative or even more wonderful universes, possibly from an actual buildable technology that causes a new aleph number upgrade version of MWI nonunity or MWI unity, and then making actual functioning technology objects that raise the aleph number at and of Hedonistic Imperative or even more wonderful majority amount (noting the majority is higher aleph number compared with a previous to technology aleph number, or even the greater amount from going from an enumerable MWI to an aleph number foundation branch amount of branches at MWI) universes is likely beneficial, and an artificial intelligence, human that is a person, a member of a group called people, P-zombie, or a sentience could ponder or process the ethics of raising the aleph number of the MWI branch universe amount when the anthropic priciple is modified at the new branch universes, at the entire amount of the higher aleph number MWI branches to create Hedonistic imperative or even more wonderful universes.

As an aside, if any of the AI, human that is persons or people, P-zombies, or sentiences make the aleph number technology that raises the aleph number of MWI banch universes with the quantity amplified universes having their anthropic principles initiated to have an anthropic principle state that causes Dave Pearce’ Hedonistic Imperative or and even more wonderful universe wide existence, everybody lives at it.

Note: Entertainment value: if P-zombies, possibly with effective computers, calculated a physics basis to cause sentience, then based on that thinking as well as possibly computation could make MWI branch universes that have sentience while being P-zombies are personally without sentience

[[

Another way to make a bigger than previous MWI, possibly even bigger than MWI unity producing actual physical object: Analog, perhaps analog arising from a higher pispansion (pispansion: When a human, that is a person or people, create, or find that at dimensions bigger than 2d (or 1D, I may have read a source of making pi at 1D)or computer number from actual physics greenshift neutrino layers that make actual analog adjustable quantum linked (entanglement) communication of state velocity chronointervals, and noting systems and actual physics technological objects that produces higher physical D, or 0,1,1 automata might have a “these digits happen to be a flatter version of the location of every atom, its location and energy at the pre-object universe (starting here, at pispansion ” at the higher physical dimensioned version of (for example) pi. The “These digits happen to be” is like the well known “these digits, at this pi interval, happen to be: all previous text written in English” So the one dfimension up from a flatter version of universe definition could possibly be at a higher aleph number, so making MWI branches go up an aleph number.

pispansion: it is possible that instant pi, rather than calculated is automatically an effect of some numberD +t; a 2D circle’s automatic diamerter perimeter ratio could be an insant pi occurence, so at higher enumerable amount D+t human thoughts or computer models, is there a thing like matrix pi with an identity that generates not only pi, but a bunch of other things as well at other considerations of the array like automatic row:column identity forms or, with a computation: eigenvalues or eigenvectors; that could be kind of like the 4 physical dimension +t and higher D+t More pi than pi, that is pispansion things.

There might be a non-aleph number upping thing though: If the aleph number of the: at greenshift a neutrino shell that makes higher D actual physics vertex geometries of new generation photons (child photons) at layered concentric geometries, each child photon with higher physical (3D -> 4D ->higher D) thing is higher than the previous aleph number with a “these digits happen to be” generator. A “these numbers happen to be” generator is like the idea that if you just find the right area of pi you can find a sequence that happens to be every english writing thus far written; so are there pispansions that have richer, easier to find, or more prominent “these digits happen to be” areas. (one might be fractal systems, if you are looking for a relative of a known bracnh style, you might find it rapidly at a fractal)

]]

Novel to me at June, 2019: greenshift vertice concentric geometry objects, where there is more than one, and they are concentric; perhaps there is an actual physics effect where a neutrino and some other thing can make another neutrino, if that is possible then neutrinos making neutrinos, at a material with a refractive index (like water) could produce various bigger amounts, from layering, of increased quantum linked (entangled) spatial dimensions (3D +1(first greenshift layer) +1 (next greenshift layer from the added neutrino layer) +1 (next higher dimension from another additional greenshift layer) then +1… and continuing +t).

Greenshift may also modify t as in 3D +t notation for 3d with time. Noting planck length systems, which this document might have found something other than, making the planck interval into a two or more component number (possibly a 1 times 2 matrix or a 2 times 2 matrix) could make actual physics better and affect MWI. Also just as an aside, what would the eigenvalue of a planck interval, length or other planck unit be or do or suggest as new technologies?

It is possible that the planck interval can be derived, rather than just be stated, from some characteristic of neutrinos, or things with a refractive index and the velocity of light; that would make the derivation equtions able to skip making it from the planck interval equationally used immediately’s effects), which causes greenshift enhanced equations to be constructed and used.

Greenshift ( I may have written a more thorough version online, and there might be a youtube video with graphics):

Produce a photon and a neutrino simultaneously. Have them travel through a material with a refractive index like water, then an actual physics effect occurs where the neutrinos travel faster than light at the refractive medium. One occurence of this is the blue light from neutrinos traveling through water producing cerenkov radiation. Then have a location at some distance where the neutrino is absorbed, which emits a completely new photon. At this sytem, the new photon is time and space advanced compared with the original pair photon, so there is discontinuous rather than continuous photon time and space location and detectability from greenshift. That produces a new lightcone from the greenshift. That is why I call it greenshift. Notably the new photon would usually emit at an angle from the linearity of the neutrino path, that causes polygons of photon location to be generated. Polygons can be used to construct things, although true circles are more optimal. At this document making concentric layers of greenshifted photons is described. Also, separate lightcones suggest many new technology objects, and could affect the artificial intelligences and technologies of transhumanism.

Among the simplest greenshift producing things would be a neutron and photon simultaneous production from some particular radioactive matter isotope, or a laser or also high energy photon beam (like x rays or gamma rays) on a material. Perhaps it is possible to perpendicularly x-ray a fiber optic bundle, or even place one at, simplistically, a water reservior next to a reactor core, then illuminate the bundle with nonreactor frequencies of x-rays, (or some other thing) to cause higher concentrations of one light color of cerenkov radiation at the water, and separately detectable photons of some different frequency emitted from the optical fiber bundle. I mention a bundle as it is imaginable that a million (1000 times 1000 core geometry with fibers 1/10 of a mm wide is just a 10 cm wide bundle) fiber bundle is buildable, or even just orderable online. Actually it looks like you can skip the reactor. Rather than edit the reactor out of the technology I will retain it for entertainement.

Perhaps there is a refractive index material that only produces cerenkov photons at a particular energy of neutrinos, then you could just have the neutrino photon pair emitter make just that neutrino energy, making detection higher resolution. It is even possible to imagine a water system where the water reacts to the neutrino producing cerenkov radiation

Spherical greenshift detector: Noting the presence of a radiation or other photon neutrino pair emitter; if photons travel 1/10 the velocity of neutrinos at some material because of refractive index, then a neutrino detecting sphere external and around a photon detector sphere could prove greenshift from measuring greenshift from any photon and neutrino core emissions angle.

A nonradioactive system could demonstarte greenshift: I have read about acoustic and some other kind of experiments where they use the shared equations of light and other waves to make things like gradualized light, and light singularities with things like acoustic wave systems. It is possible that acoustic systems could demonstrate greenshift, then as to the neutrinos, perhaps at integrated circuit (IC) technology a bunch of cheverons with a gaps

So, an IC material thing with some actual physical spheres at it, (moveable physical O that imitate neutrinos) The IC has a bunch of O->>>>>>>>>>⏍ at its physical form, which also receives acoustic waves, is placed at a material with a very high acoustic refractive index, then the O particles are shown to move through the >>>> more rapidly than the acoustic waves can get there, and then when it gets through the >>>>> then meets the ⏍, it emits a completely new acoustic wave (the : ‘ ) which is measurable as having a different direction. perhaps people could draw cad like drawings of grouping of these to make new photon greenshift machines, and then make them. Computational automata, like 1,1,0 might be much easier to make with a few million of these O->>>>>>>>⏍ CAD arranged at patterns.

Technology: make a glider gun at a greenshift IC, then there is a auto reinforcing auto repeating photon-like system, which as far as I know is new technology. acoustic nanometer features at IC fabrication could be implausible, except at what wikipedia describes as “time crystals” or perhaps proteins, but photon glider guns could possibly deposit energy at depth of an IC wafer, creating 3D computer chips.

Also, (photon torpedos!). At acoustic greenshift it is possible the O physical particles could get an initial velocity from something like the laser tractor beams I read about, that way the Os get a start on their motion

Kind of reminds me of a binomat with a tweeter aimed on the edge, inside a bowl of Jello.

The glider gun at an acoustic version of greenshift at IC technology reminds me of what wikipedia calls time crystals, like time crystals, perhaps glider guns are, or could have, multiple ground states that get rotated through, or if not rotated only traverse area when they get a stochastically favorable sequence that causes motion.

modifying the anthropic principle at MWI branch universes: Some versions of the anthropic principle favor Dave Pearce hedonistic imperative or even more wonderful as a starting form that is unchanging, time crystal like, or heightening in enhancement and well being. Calculating what causes those universes and creating an anthropic principle causative technology at MWI branch universes, or even a Higher aleph number volume of these Hedonistic Imperative or even more wonderful universes, possibly from a new aleph number upgrade version of MWI unity, and then making actual functioning technology objects that raise the aleph number at and of Hedonistic Imperative or even more wonderful universes is likely beneficial, and an artificial intelligence, human that is a person, a member of a group called people, or a sentience could ponder or process the ethics of raising the aleph number of the MWI branch universe amount when the anthropic priciple is modified at the new branch universes, at the entire of the higher aleph number to create Hedonistic imperative or even more wonderful universes.

Noting the greenshift spatialization that is discontinuous and higher velocity than: light at a refractive index (cerenkov radiation instance), then it is possible the discontinuous spatialization changes a definition, then the planck interval starts being a two component number systems (a 1 times 2 matrix? a 2 two times 2 matrix?) which could have technology applications, as well as be a descriptive improvement at science.

What might be a cheap way to make a true analog actual physics sytem is if raising a system an aleph number is, as a result of the way the universe works, technologically and conceptually facile and rapid to accomplish; it looks like an aleph number would be analog across the entire system, even if a particular interval might be quantized: All the integers is aleph 0, but 14,15,16 is like a quantized, plank-voxel like thing. So an actual physics system that does aleph numbers or raises a sytem to aleph numbers could make a true analog, and a true analog could be used to modify the amount of MWI universes as well as create other technologies while also being new science of physics.

Perhaps a simple way to make an aleph number, even with planck length voxels,

At the versions of greenshift where the neutrino causes a new photon emission to be at an angle to the neutrino’s travel path, (prior to the arrival of the light photon from the neutrino photon pair producing event), then there is a trigonometric relationship perhaps this could be sifted through to find out if it could make an actual physically analog thing (long, possibly easier to measure ___—— polygon sides produced from making a greenshift spatially discontinuous photon occurence to my perception come from really narrow angles.)

note: if you have a discontinuous time as well as possibly horizontal space jump from greenshift, does that effect simultaneity coexisting with nonsimultaneity at relativity or special relativity? It might tart up the equations some.

of

I think I might have also made a greenshift youtube video.

Then you can do the obvious thing and generate analog * analog effects sufficient to generate a planck length ocurence, which is then, I think, the size to effect matter.

If a combinatorial series at a group of physical objects like 3 mermaid dolls produces more dolls with each recombination does the series be without termination?

Any computer program that does i++

A neutron creating a proton, and the proton grabbing an electron from the casimir effect, then having a nonfinitude of photon emission levels; any other quantum physics thing that does something like this.

Longevity technology:

• The peptide AEDG is published as causing greater longevity in laboratory mammals, making a version of AEDG with weekly, monthly, or annual dosing is beneficial.
• Fluoexetine palmitate is once weekly dosing; AEDG palmitate could be weekly dosing
• Some proteins glom to circulating albumins like SHBG strongly, it is possible that attaching AEDG to one of those proteins with a very gradually dissolving enzymatically dividable linker could cause 1 to 3 month AEDG dosing intervals and be orally administered
• I may or may not have read about injectable ID, if that is non-isotopic then AEDG linked to that chemical could have annual or multiyear dosing.
• 
  

Epithalon (also known as Epitalon) is the peptide AEDG

AEDG peptides in concentrations 0.05-2.00 ng/ml on organotypic skin cell cultures proliferation in young and old animals were investigated. Peptides stimulated skin fibroblasts proliferation on 29-45% in skin cell cultures of young and old rats.

https://www.ncbi.nlm.nih.gov/pubmed/25946846

[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].

[Article in Russian]

Popovich IG.

Abstract

The review presents the results of experimental studies conducted by the author. CBA, SHR, HER-2/neu and SAM mice revealed inhibition of age-related alterations in estrus function and spontaneous tumour development and showed life span extension under the influence of the pineal gland hormone Melatonin, synthetic peptide bioregulator Epitalon, delta-sleep-inducing peptide Deltaran, enterosorbent Aqualen and succinic acid containing preparation Neuronol (Noogam). The observed effect depended on the dose and conditions of administration, as well as genetic predisposition of the particular mice strains to tumour development.

https://www.ncbi.nlm.nih.gov/pubmed/15559508

Wikipedia says:

A human prospective cohort study conducted on a sample of 266 people over age 60 demonstrated that treatment with epithalamin, the pineal gland extract upon which Epitalon is based, produced a 1.6-1.8-fold reduction in mortality during the following 6 years, a 2.5-fold reduction in mortality when combined with thymulin, and a 4.1-fold reduction in mortality when combined with thymulin and administered annually instead of only once at study onset

also:”following 3 years of biannual epithalamin treatments, as well as a 50% lower rate of cardiovascular mortality, a 50% lower rate of cardiovascular failure and serious respiratory disease, and a 28% lower rate of overall mortality” https://en.wikipedia.org/wiki/Epitalon

I perceive that I read AEDG (epithalon) makes laboratory rodents live about 24% longer, during 2019 I found:

Epithalon (0.1 microg daily 5 times a week from the age of 4 months) did not change the life span of rats living under conditions of standard day/night regimen, while in rats exposed to the natural and constant light it promoted prolongation of the maximum life span by 95 and 24 days, respectively. Epithalon prolonged the mean life span of the last 10% of rats exposed to natural and constant illumination, treated with Epithalon, by 137 and 43 days, respectively.

https://www.ncbi.nlm.nih.gov/pubmed/18856211

If a rat lives about 2.5 years, then the 137 day number is about 6.6 ish % longer lifespan

Mammal studies are better, but at drosophila:

The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva).Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations-from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females. The increase in LS did not depend on the substance dose. Effective concentrations of epitalon were 16,000-80,000,000 times lower than those of melatonin.

https://www.ncbi.nlm.nih.gov/pubmed/11087911

The structures and metrics of peptides and the DNA double-helix cause the recognition and complementary binding of a regulatory peptide with DNA functional groups at the interface of the major groove. We have used complementary binding model to find a possible base pair sequence ATTTTC for specific binding of synthetic tetrapeptide epitalon. This base pair block and its reverse complement were found repeatedly in the promoter region of telomerase.

https://www.ncbi.nlm.nih.gov/pubmed/15990728

Longevity technology:

• The peptide AEDG is published as causing greater longevity and wellness in laboratory mammals, making a version of AEDG with weekly, monthly, annual or multi-annual dosing is beneficial.

• Fluoexetine palmitate is once weekly dosing; AEDG palmitate could be weekly dosing

• “Paliperidone Palmitate 3-month injection” suggests 3 month injection could function 3 months, noting the few nanograms or few milligrams of AEDG it is possible to think an AEDG palmitate could last longer than three months. “Six-month depot formulation of leuprorelin acetate” suggests 6 month AEDG dosing could be functional.

• The needleless injection technology that is like transdermal sugar dermal piercers could work at the nanograms to milligrams of AEDG to provide beneficial effect. “AEDG peptides in concentrations 0.05-2.00 ng/ml on organotypic skin cell cultures proliferation in young and old animals were investigated. Peptides stimulated skin fibroblasts proliferation on 29-45% in skin cell cultures of young and old rats.” (PMID:25946846) suggests a therepeutic effect over a range of 1 to several hundred units of dosage having beneficial effect, that gives the possibility of the beneficial human drug being active at even transdermal needleless injection.

• The dosing amount of epithalon, AEDG might be larger than the mg dosages described at other items here. “Injectable Epithalon use (most effective): duration: 10 - 20 days dosage: between 5 - 10 mg per day”, also, “Each 10 - 20 days course of Epithalamin is followed by 4-6 months pause before repeating” (http://steroid.es/epitalon.html) suggests that 100-200 mg depot injection annually could be beneficial. Supporting nanogram to single milligram 6 month or longer depot dosages is, “In vitro biotesting included the determination of the proliferative activity of thymocytes, a bimodal curve with the second maximum were detected at super-low doses (10(-17)-10(-15) mol/l). Authors propose a hypothesis that for superlow concentrations the formation and distance transmission of a signal from ligand to a target cell without the formation of any ligand-receptor complex take place.” (PMID:12881997)

• AEDG is orally active in rodents, it is possible AEDG toothpaste could beneficially dose humans.

• Some proteins glom to circulating albumins like SHBG strongly, it is possible that attaching AEDG to one of those proteins with a very gradually dissolving enzymatically dividable linker could cause 1 to 3 month or greater AEDG dosing intervals and be orally administered. Oral dosing: salmon calcitonin linked peptides pass through the GI tract for oral delivery of peptides.

• I may or may not have read about injectable chemical ID, if that is non-isotopic then AEDG linked to that chemical could have annual or multiyear dosing.

• Putting an atom or a few on the AEDG peptide, like changing the =O to -OH at few places, or changing hydrophilicity or lipophilicity could make nanogram dosing possible from modifying the distance between AEDG and a cytostructure or external cytomembrane structure, rather than the activation of a receptor with AEDG, “In vitro biotesting included the determination of the proliferative activity of thymocytes, a bimodal curve with the second maximum were detected at super-low doses (10(-17)-10(-15) mol/l). Authors propose a hypothesis that for superlow concentrations the formation and distance transmission of a signal from ligand to a target cell without the formation of any ligand-receptor complex take place.” (PMID:12881997)

• Variations on AEDG that do the “to a target cell without the formation of any ligand-receptor complex” thing at nanogram dosages: deuterated AEDG could have slightly different intramolecular distances; blood brain barrier passing version of AEDG like diacetylAEDG (possibly with enzyme degradable linker molecule),

• • Lysine-EDG (LK) is similar to AEDG, and has both similar and different effects.

• There are over 100 mentions of epithalon, AEDG at pubmed, epithalon is a pineal peptide, there are numerous other pineal peptides that could be beneficial to humans, “Within the epiphysis polypeptide complex, free amino acids (3.26%), dipeptides (23.19%), tripeptides (50.72%), tetrapeptides (22.10%), and pentapeptides (0.72%)” The thing is though, “The biological effects of the epiphysis polypeptide complex are determined by the effect of its component AEDG”

• • The peptide KED (Lys-Glu-Asp) is about 40% more effective at, “The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.” also: “Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis”

• There is also a nonapeptide, thymulin, wikipedia says, “Thymulin” “is a nonapeptide produced by two distinct epithelial populations in the thymus” “It requires zinc for biological activity. Its peptide sequence is H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.”

• “acetylated and acetyl-amidated versions” of AEDG are described, that reminds me of acetylation to cross the blood brain barrier and possibly other cytomembranes: https://www.reddit.com/r/Nootropics/comments/3ji7d8/epitalon_any_noticeable_results/

• Also, attaching AEDG to a protein with favorable cytomembrane transport channels, likely with an enzymatically degradeable linker molecule or ATP or polyATP could cause the AEDG beneficial effects at lower doses making annual or multiyear dosing more effective.

• nuclear membrane transport channels: Also, noting “cause the recognition and complementary binding of a regulatory peptide with DNA functional groups” It is possible a material that causes AEDG to be preferentially transported to the nucleus through the nuclear membrane could increase the activity of AEDG at any particular dose, making annual or multiyear dosing even more effective.

• noting, “The structures and metrics of peptides and the DNA double-helix cause the recognition and complementary binding of a regulatory peptide with DNA functional groups at the interface of the major groove. We have used complementary binding model to find a possible base pair sequence ATTTTC for specific binding of synthetic tetrapeptide epitalon. This base pair block and its reverse complement were found repeatedly in the promoter region of telomerase.” It is possible there are different genotypes for the ATTTTC sequence and that persons with variations can be measured as to wellness and longevity to find an optimal version of the sequence. The more optimal sequence could then be made part of the human genome. AEDG could also be produced at human, that is persons, that is people’s tissue with gene therapy.

• Mammal and human studies could find out if AEDG which effects melatonin production benefits the fetus and baby as much as melatonin is published as benefitting fetuses and babies, This study notes higher fertility when conceiving and greater resistance to trouble at the new baby, “Melatonin receptors are widespread in the embryo and fetus since early stages. There is solid evidence that melatonin is neuroprotective and has a positive effect on the outcome of the compromised pregnancies.” The journal article also says, “The pineal gland develops completely postpartum, so both the embryo and the fetus are dependent on the maternal melatonin provided transplacentally. Melatonin appears to be involved in the normal outcome of pregnancy beginning with the oocyte quality and finishing with the parturition” Also, “Melatonin decreases in conditions associated with serious outcome for the fetus and seems to be involved in preeclampsia and intrauterine growth restriction [7]. Melatonin treatment during human normal or abnormal pregnancy has been studied for a large range of conditions and at different times during the gestational period. Considering the ethical issues, it is more difficult to study a normally occurring pregnancy, than an in vitro fertilization (IVF) one. Melatonin administration started prior to IVF-cycles, continued during pregnancy and was associated with improved pregnancy outcomes”, also, at in vitro fertilization, “Fertilization success and pregnancy rate were improved by melatonin treatment. Fertilization rate was 50% higher in melatonin treatment cycle“ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316124/

•

• • AEDG, epithalon is on alibaba.

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• GSK Drug delivery technology if surgical glue is painted on a body surface does it do transdermal drug delivery with a one time monthlong or longer lasting swab which is more advantageous than other transdermal methods. Foot area or buttock cleft or acute angle area of knee could be possible sites, with the knee angle administerable easily by the user. It might be fine on clean skin, but a thioglycollate (keratin dissolving) or microdermabrasion moist pad might be a beneficial surface prep.

Biopolymers like prebiotic fiber transparent gels, starches, and other biopolymers are soaked in AEDG, and dried, their core remains dry and much of the peptide is shielded from aqueous environment and digestion until reaching the intestines. There microorganisms treat the fibers or gel like prebiotics digest the fibers emitting the AEDG. Alkaline pH and having the biopolymer be purposefully positively or negatively charged like an electret could benefit both shielding and dissolving or prebiotic emission of AEDG. Also, a hydrophobic AEDG emulsion could be used to saturate the fibers, so it would be a dry lipid soaked core.

• An AEDG as well as other peptide or protein drug transporter: something like DMSO that transports things through the skin but is different because it only goes 1 or 2 mm deep; it is easy to say “diethyl or dipropyl sulfoxide” although it is possible that works. The idea is that transporting a drug only 1 or 2 mm deep, but not further, basically places what previously was a transdermal applique application or effect under the skin, where it does not come off and might have characterizable dosing effect. Similarly, liposomes that only go 1 or 2 mm deep are a possible drug delivery technology: Magnetic liposomes exist, they could be pushed through the dermis causing a depth attaining effect only when the magnet is applied. It is also possible that lasers could drive 1-2 mm dermal transport photochemistry that causes an active drug linked to the photoactive transport molecule to diffuse at light-adjustable depth at the dermis; lipophilic to hydrophilic illumination changeable molecules could be a form; a photoactivatable zwitterion could be a form, or a drug molecule linked to a e- charge changing molecule could be a form: I perceive there are many photoactive e- GRAS molecules, among them: chlorophyll, rhodopsin, and the version of vitamin D that uses UV to change into an active form. The active drug could be attached to the light driven molecule with an endogenously available body enzyme degradeable linker molecule, ATP, or polyATP that separates the active drug from the photomigrating molecule.

•

• It is possible that as AEDG is only four amino acids long that yeast or yogurt bacteria could be bred purposefully to produce it; I perceive yeast and bacteria secrete peptides, to their media as well as harbored endogenously at the microorganism, to make AEDG at a microorganism with breeding: the existing highest amount of mg per volume produced peptide that is secreted that the organism produces, at possibly 4-7 amino acids long could be the high volume secretion or endogenous cytoplasm peptide to modify to produce AEDG; exposing a microrganism to a mutagen like UV then screening a bunch of microarray culture plates to find those that had replaced the first of their already produced, high volume secreted peptides’ amino acids to be alanine (The A in AEDG), then reculturing those at a new array of microarray culture plates, exposing to a mutagen until the next amino acid produced was an E, then continue cycling until D and G were produced in the sequence AEDG is a way to do this. I also favor directly genetically engineering AEDG of an orally available form like salmon calcitonin linked AEDG to be in a common deliciousness enhanced plant or even a weed species.

•

• Previously described is a transparent michael reaction (henna effect) chemical reaction with keratin at dermis (notably at beauty peptides and sunsceen) which causes much longer lasting dosing, this could be used with the nanogram doses of AEDG, if nanogram dosing is quantitatively measured as heightening wellness and producing greater longevity.

•

Chewels and white chocolate as AEDG snacks, noting that .5 to 250 units of AEDG activity is published as beneficial, if you eat 10 candy treats or 5000 candy treats you are ok. Also once every few months (human AEDG dosing every 6 months at one study) you get to eat more candy, and knowing it is beneficial to you, many food concerns might be ignored. You could even click on “get a subscription and twice a year you get chewels and white chocolate as you prefer” online.

Chewels are yummy fluid centered gum; they squirt in your mouth when you chew on them. They could be filled with an AEDG shielding emulsion at hydrolyzed or dry fiber or variously a biopolymer (beta glucans or starch, artificial microtapioca); The spurty gelid delicious chewels flavor experience contains 5 mg of AEDG each, so two chewels three times a day.

At one published study on AEDG (where the human dose is described) it describes 10mg three times a day for ten or twenty days, and then 6 months between sessions. That is 300 to 600 mg per AEDG treatment unit. At 1 mg per white chocolate treat you get to eat three groups of ten white chocolate treats a day, the thing is if you eat 40 treats a day you are still at the effective beneficial dose range (.5 to 250 units) for AEDG and get to eat lots of treats.

There is published literature on orally available peptides. It is possible the technologies that make a particular variation on vasopressin causes 75 times more absorption at double strength could be utilized at AEDG, “Modifications of individual amino acids combined with the substitution of one more L-amino acid with D-amino acids can significantly alter physiological properties. This was demonstrated by vasopressin analogs 1-deamino-8-D-arginine vasopressin (DDAVP) and [Val4, D-Arg8], arginine-vasopressin (dVDAVP), hereafter called desmopressin and deaminovasopressin, respectively. While the former involves deamination of the first amino acid and replacement of the last L-arginine with D-arginine, the latter also has the fourth amino acid changed to valine. While the natural vasopressin is orally active in the water-loaded rat at large doses, desmopressin is twice as active at the 75th fraction of the dose, which is attributed to enhanced membrane permeation and enzymatic stability. Desmopressin absorption was shown to be passive and by the paracellular route across the rat jejunum and site dependent in rabbits. Whether the chemical modification alters the transport pathway, however, remains to be unknown” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/

A plurality of technologies I have thought of utilize enzymatically dividable linker molecules, sometimes between an active drug and a transporter molecule. At some areas like cytoplasm applications like making multiparallel molecule transport versions of a drug I perceive value; Some other applications like peptide and protein drugs, among them AEDG, may benefit from highly affordable, mass consumable, thrifty to manufacture drug emitting systems. AEDG Soaked fibers or an emulsion that separates at a higher pH part of the intestines could be more value effective to manufacture as compared with a sequentially reacted peptide-enzymatically dividable linker-salmon calcitonin molecule.

At peptide transport, shielding from stomach acid, an edible biopolymer like beta glucans, starch, or hydrolyzed fiber could be advantageous. pre-colon intestines are higher pH and have bacteria that treats some kinds of fiber as prebiotic nutrients. These bacteria soften and ingest the fiber releasing the AEDG from the dry or lipid emulsion soaked core area at the intestines.

Along with the quantifiable AEDG emission of dry core fibers is the emulsion technology. edible oil or other gooey lipid is pressed into the fiber, reaching the dry core, which is now a hydrophobic oily drug transporting core. with AEDG absorbed onto biopolymers or prebiotic fibers or even hydrolyzed fiber , with or without an emulsion, which emits 1 to 3 mg of dose for each 3 mg of AEDG and absorbed at the gi tract after it gets prebiotically digested and emulsified at the intestines, separating the lipid from the biopolymer (like beta glucans or starch or fiber gel) that the AEDG is adsorbed on causes the AEDG to desorb from the biopolymer surface.

Also, it is my perception that biopolymers can be positively or negatively charged, causing the AEDG to cling to them rather than diffuse and agitate out from peristalsis.

It seems kind of direct, but AEDG soaked biopolymer, perhaps actual fiber similar to the transparent fiber in existing human fiber supplements, such that the core of the fiber is dry or lipid emulsion aqueous contact reduced has emittable AEDG unexposed to stomach contents, could release the AEDG when bacteria digest the fiber, prebiotic style.

The fibers could be made at various diameters if AEDG is quantitatively measured as being its most effective, longevizing, and wellness producing at a steady plasma curve: a few sizes of diameters of fibers would make some prebioticized and emitted rapidly while others would emit AEDG hours later.

AEDG Soaked fibers or an emulsion that separates at a higher pH part of the intestines could be value effective to manufacture as compared with a sequentially reacted peptide-enzymatically dividable linker-salmon calcitonin molecule. I have read that attaching a peptide to salmon calcitonin produces effective oral delivery of peptide drugs. There is also an oral form of vasopressin available.

AEDG dosing at about 9.2-18.4 cents annually: A thing of generic multivitamins is near $7, a 2019 AD guide to people’s value point. So what is the actual manufacturing $ to produce an AEDG tetrapeptide dose sequence: It is possible it is about 4 to 8 cents. Online collagen peptides are $43 for 20 oz., very similar to a number of drug peptides, are $8.95 per 100 grams, so 8.95 cents a gram, and each twice annual dose is 300 to 600 mg, so about 2.6 to 5.3 cents for the actual AEDG at the product, or less than 11 cents a year. Note, even if four times the AEDG is used to produce a unit dose, from absorption, reaction with intestineal contents, and other amount of drug that reaches the circulatory system effects that is near 21 cents a year for the active ingredient. Making the varied diameter fibers that are prebioticized, and are soaked with pH and time release AEDG it is plausible that filter paper is a value model; At some amount of quality, that is near $1 for 100 grams. So that is 1 cent a gram, and if each dose of AEDG occupies a fortieth of the mass of the prebioticized fiber then 300-600 mg becomes 12 to 24 grams of fiber for each semiannual dose or 2 to 4 cents for the prebioticized fiber per AEDG dose sequence.

At manufacture then, a full AEDG dose sequence is 4.6 to 9.2 cents to manufacture. Twice annually that is 9.2 to 18.4 cents year. Noting that generic multivitamins are near $7, the earnings is 38-76 times higher than how much $ to produce the product.

Also, published material says, oral“desmopressin is twice as active at the 75th fraction of the dose” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/, so it is my perception that oral drug delivery of AEDG and thymulin is possible; the published 150 times more effective oral dose efficiency compared with the unmodified peptide, combined with the .5 to 250 dose units to produce benefit at AEDG, causes a potency range where 1.6 (250/150) to .0033 (.5/150) is the range of published AEDG dosage amounts at the 150 times efficacy of the oral vasopressin peptide.

Another peptide, the nonapeptide thymulin could be combined with AEDG to quadruple the reduction in mortality.

Benefit: AEDG caused “a 2.5-fold reduction in mortality when combined with thymulin, and a 4.1-fold reduction in mortality when combined with thymulin and administered annually instead of only once at study onset” https://en.wikipedia.org/wiki/Thymulin

rent room in eureka during santa barbara overlap

Pupillometry predicts creativity; so do activities that cause similar pupillometric behavior as creative tasks cause more creativity? COuld children’s toys measure the amount of imagination pruring play to make better toys and play suggestions? (CCA; cortana child advisor, voluntary amazon alexa echo speaking guidance of play

https://www.tandfonline.com/doi/full/10.1080/10400419.2018.1530533

Creative play is teachable, “This study investigated the effects of a pretend play intervention on 45 first and second grade children 2–8 months post-intervention. It was hypothesized that pretend play would be improved in the intervention groups and that they would score higher than controls on measures of play, creativity, and emotional processes. Subjects were randomly assigned to an affect, imagination, or control group. The imagination group significantly increased on multiple play scores from baseline to follow up and compared with controls, scores on frequency of positive affect expression were significantly higher. Differences on other scores were not found. Results indicate that play skills can be improved and cognitive play skills may have a stronger impact on affective processes than anticipated.”

Female university students (n = 104) were randomly assigned to a coloring intervention or a logic-puzzle control group. Participants completed an inventory of psychological measures (depressive symptoms, stress, anxiety, flourishing, resilience, mindfulness) and then participated in a 1-week intervention of either daily coloring or logic-puzzles. Following the intervention, participants again completed the inventory of psychological measures. Coloring participants showed significantly lower levels of depressive symptoms and anxiety after the intervention, but control participants did not.

Increasing the well being of girls may increase their creativity, “The development of analytical abilities was predicted by visual and verbal short-term memory and self-concept, the development of creative abilities by visual short-term memory and well-being” among 6th graders.

Physical “outward bound” programs, are to my perception, described as increasing self esteem and might increase well being. Could a computer graphic form of “outward bound” be possible?

Nifty thing zaps antibiotic resistant bacteria, “attached a cephalosporin molecule to a secondary antibiotic called ciprofloxacin.”…”When resistant bacteria encounter the combined drug they cleave the cephalosporin, setting the ciprofloxacin free to kill the bacteria.” https://www.imperial.ac.uk/news/191213/decoy-antibiotics-could-around-bacterias-defences/

An upside version of the same mechanism: could NMN linked to another molecule visit (get more use at) known good mitochondria, then cleave to put another beneficial molecule in place? Possibly a “fission (duplicate) this mitochondria” chemical or nucleotide? Finding the healthiest 10% of cytes at the body, with the most mitochondria, then causing them to do mitosis could cause higher quality tissue, promoting wellness and healthspan. It is possible that doing mitosis on the ones with the most mitochondria at the tissue of 80-120 year olds could beneficially increase the mitochondria per cyte numbers.

Some probiotics could reduce risk of stroke, “Regulatory T [(RT)] cells have a beneficial inflammatory effect, protecting an individual from stroke. But gamma delta T cells produce a cytokine that causes harmful inflammation after a stroke.“

Probiotics that increase RT, or not: ”After 10-d treatment with Bifico capsules (combined bifidobacterium, lactobacillus and enterococcus)”, “a combination of Lactobacillus gasseri, Bifidobacterium bifidum, and Bifidobacterium longum”, “Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2” However, “Regulatory T cells, which are anti-inflammatory cells of the immune system, increased during the study in all participants but there were no differences between the probiotic and placebo group.”

Longevity technology:

Online https://www.longecity.org/forum/topic/94224-manipulating-mitochondrial-dynamics/ it says that NR, which is kind of like NMN, to be available has to be enzymatically divided into niacinimide and ribose to affect NAD levels. “Perfused or intact intestine rapidly hydrolyzed NMN to nicotinamide riboside, which accumulated, but was not absorbed. It was slowly cleaved by an enzyme associated with the mucosal cells to nicotinamide, which was the major if not the only labeled compound absorbed.” Notably Ribose is only $36/Kg at amazon, and I think nicotinamide is about $11 for 90 grams. so verifying that NR gets cleaved prior to ever reaching cytes suggests the mouse 20g human equivalent dose a day benefits from ribose with nicotinamide. One plausible thing the person at imminst/longecity says is that nicotimide does lots of mitochondrial fission. “see my Exercise Like a Girl post. http://www.longecity.org/forum/topic/93915-exercise-like-a-girl-a-protocol/ In particular my last reference that indicates NR must be cleaved by enzymes to be absorbed. So taking nicotinamide plus a greater than stoichiometric dose of ribose is essentially taking a predigested NR, except you won't have to wait hours for maximum effect on NAD, and more of the nicotinamide will be converted into NR in the body with the excess of ribose.” … “For fission, my dose is 2g NAM + 5g ribose (equivalent to >4g NR)”

So with a plasma half life of 3.5 hours for nicotinamide and “70” minutes for ribose (D-ribose was rapidly absorbed (Tmax=36–44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18–37.5%) recovered from urine) that suggests 4 times a day dosing for about a month. Ribose tastes yummy though.

I perceive NMN and NR are similar.

A probiotic that produces ribose and nicotinamide could be a wellness probiotic.

Actually, my perception is that lots of eentsier mitochondria where mitophagy, removing nonfunctional mitochondria is favored, sounds nifty, Caloric restriction increases mitophagy, as, the NR workalike I read about says it does..“work in S. cerevisiae links optimal mitochondrial quality with longer lifespan (Higuchi et al. 2013).” also, “an increase in mitochondrial fission would create many fragmented mitochondria, which has been shown to be useful for eliminating damaged mitochondria and for creating smaller mitochondria for efficient transporting to energy-demanding areas” Distal parts of cytes like dendrites could benefit. It could support endogenous pre-existing stem cyctes as well, “stem-like cells division is asymmetric; some cells inherit mainly “old” mitochondria and loose their stemness properties (self-renewal and pluripotency), whereas others get young mitochondria and stay stem-like. This indicates that a mechanism exists to sort old and young mitochondria and highlights the importance of mitochondrial turnover and quality in maintaining “stemness””, also, supporting some mitochondrial fission, “a huge increase in fusion are detrimental. These include studies that show mitochondria hyperfilamentation that is apparent in brain from patients or mouse model of AD and leads to cellular senescence” So at a human, a month of mitochondrial fissioning NR workalike could cause mitochondrial improvement. The thing is that at yeast, fewer, and larger mitochondria go with greater highest longevity, “ Also, at yeast and rodents, caloric restriction causes less fissioned mitochondria, “On the other hand, caloric restriction has been shown to decrease the expression of mitochondrial fission factors Drp1 and Fis1 and to upregulate the fusion factor Mgm1, resulting in a more filamentous network (Goldberg et al. 2009). In Rat, caloric restriction leads to the same effect and an increase in cristae number has been observed” That suggests a temporary fission fest could be beneficial but a mitochondrial fusion fest could also have value. “MtDNA mutations tend to accumulate when the fusion/fission cycles are less frequent and there is less mtDNA mixing. Fusion appears to be important for mixing content of different mitochondrions (Tam et al. 2013; Chan 2012) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935730/ LCA and lactic acid might cause mitochondrial fusion:

At a concentration of 50μM, exogenously added LCA (“Lithocholic acid, also known as 3α-hydroxy-5β-cholan-24-oic acid or LCA, is a bile acid that acts as a detergent to solubilize fats for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group […] It has been implicated in human and experimental animal carcinogenesis.[2] Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations)

was found to extend the mean and maximum chronological lifespan of yeast.[6] The bile acid accumulates in the inner and outer mitochondrial membranes, altering the mitochondria's lipid composition by promoting or inhibiting various enzymes.[7] The remodelling of the membranes changed the shape and number of mitochondria in the cell by (1) increasing their size, (2) decreasing their numbers, (3) decreasing the number crista extending from the IMM and (4) increasing the number disconnected crista in the mitochondrial matrix.[7]Then, after the month or two of eenstsier high mitophagy mitochondria, an actual person might prefer a different more ATP generative sizeier size of mitochondria. LCA or Lactic acid might work: “Lactic acid exposure increases the size of muscle mitochondria thus improving the lactate threshold.” I suppose that suggests like, lactic acid with sucralose, or yogurt.

The imminst/longecity person’s emphasis is that their NR workalike will I perceive, that like NMN it could cause youthful phenotype at a variety of tissue types. From fMRI, It is possible thinking exercises the brain, although I think I read that people get really neurally efficient at things they are mentally good at.

Trehalose as a mitophagy inducer, “in the mouse where old mice have been fed with trehalose, a mitophagy inducer. These mice displayed an improvement of the levels of the mitochondrial quality controls mediators, especially PARKIN, BNIP3, SIRT3 and PGC1α, when compared to controls mice (LaRocca et al. 2014). Their artery walls do not stiffen and these results were reproduced ex vivo on arterial rings. As reported earlier, caloric restriction diet leads to increased mitophagy and decrease in both mitochondrial damage and markers of senescence in rats” The mice received “Controls received regular drinking water, and treated animals received 2% trehalose (Sigma-Aldrich) supplemented water for 4 weeks” So at a human that would be 20g a day in a liter of water, or 33g because it tastes good and a Kg doses a human for 4 weeks. Trehalose is at ebay and tastes good.

The mitochondria in oocytes might be super well preserved or in a state where they are prompted to be absent degrading while keeping the oocyte alive, as every 2019AD human mitochondria is the product of a species-lengthy chronological maternal lineage of 100% mint mitochondria. The biochemistry of keeping those mitochondria fresh could possibly have longevity chemical and research applications. Are those oocyte mitochondria just the right volume and shape, running at just the right amount of ATP produced per nanogram of tissue, possibly even optimally located compared to other oocyte organelles on actin traces. If so, then making mitochondria throughout the body produce that much ATP per nanogram of mitochondria, that mitochondria size and morphology, and that area of actin line support; of course cytes at tissues differ very much, but that could be an aim-for guide to mitochondria that were at active living yet pristine preserved shape at all ages; that could be a healthspan, wellness, possibly also longevity technology.

Mitochondria have a construction molecular transport molecule-mover that works on a bunch of stuff, “Precursor proteins will be transported to one of four areas of the mitochondria, which include the outer membrane, inner membrane, intermembrane space, and matrix.[10][11] All proteins will enter the mitochondria by a translocase on the outer mitochondrial membrane” So mitochondrially active drugs could among other transport channels use that translocase, possibly to move really large proteins into the mitochondria.

Longevity technology: Oral or probiotic broad brush enzymes: The broad brush approaches like “more histones” to organismal wellness and longevity could have other members. It is possible that enzymes that take a broad brush to materials in the cytosol/cytoplasm could have wellness and longevity effects; a monoxygenase, an acetylase, a methylase, an ethylase, a benzene-opener enzyme, a deaminase, an alpha-helix remover, as well as others could all be linked to a cytomembrane molecular transport protein or peptide, then these enzymes reach the cytosol at all the tissues, where they have a 1-10% broad brush effect. A bunch of these enzymes can be made into a library and then screened as to longevity hieghtening effects.

If it has not been previously mentioned I read that gene therapy on the liver was more than 99% effective during about 2005 AD, so if any of the broad brush enzymes have a longevity effect a dose of gene therapy to the liver to produce them would cause them to be endogenously produced and placed in circulation for a one dose longevity treatment. On verification of hieghtened longevity and human well being making the broad brush enzymes a part of the human germline is beneficial.

(no clue: would a ribozyme be more or less durable than a protein enzyme?)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935730/ Research on a disease could result in cognitively enhanced, longer lived humans. Mice knocked out for Surf1 (Surfeit locus protein 1) “not only these animals failed to show spontaneous neurodegeneration at any age, but they also displayed markedly prolonged lifespan, and complete protection from Ca(2+)-dependent neurotoxicity”, and also, “enhanced memory in Surf1 KO mice”; however at 2019 AD humans some Surf1 genetic variants were unwell, but it is possible a new engineered gene variant of Surf1 could be lifespan increasing intelligence enhancing, and neurobeneficial at human beings.

This paper describes links between preeclampsia and things that could be treated with longevity drugs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556237/ telomere length, mtDNA quality, mitochondrial function;

Noting trehalose causes softer blood vessels and mitophagy it might have some benefit to pregnant women and fetuses, “They established that high lipid peroxidation levels are a result of escalated mitochondrial mass in poor vascular flow to meet energy requirements in preeclampsia” If it an actual thing that trehalose, or possibly ribose, is a thing that benefits pregnant women and fetuses then these sugars could be genetically engineered into fruit so there can be a weller baby, easier pregnancy fruit

“Apart from mitochondrial dysfunction, inflammation and inflammatory mediators are evident in premature ageing of the placenta. Certain ageing-associated inflammatory markers such as Senescence-Associated Secretory Phenotypes (SASPs) are elevated in preeclampsia” suggests boswellia active chemical could be tested in mice, then humans to see if it improves pregnancy and baby wellness, “The active ingredient is boswellic acid, which has been shown to exhibit anti-inflammatory, anti-cancer, analgesic and immunostimulant properties.

Studies have linked both asthma attacks and inflammation to excessive amounts of leukotriene in the body. Leukotriene is a substance that is produced by 5-lipoxygenase.

Boswellia contains four different acids that can neutralize leukotriene. Of the four, Acetyl-11-keto-beta-boswellic acid (AKBA), is considered to be the most potent when it comes to reducing inflammation.”

Another drug they could test on pregnant mice and then if it causes benefit, humans, are longevity fungi; Reishi causes mice to live 9-20% longer https://www.lifeextension.com/Magazine/2013/2/how-reishi-combats-aging/Page-01 so could address some of the preeclampsia mechanisms. 1/5 less maternal and baby risk from a herb-at-a-glance prior to further drug development is a beneficial possibility of reishi. Also, Reishi has many component chemicals so it is likely that a partial set of those is more optimal for pregnant women and their fetuses.

Noting the researcher’s paper that likely causes many people to think that longevity technologies could benefit mothers and babies:

It is nifty to think of a matrix experiment where they have pregnant mice getting reishii, boswellic chemicals, trehalose, metformin (a mitophagy chemical), LCA(mitochondrial fusion), and NR (mitochondrial fission) or NMN at various concentrations and combinations and finding the optimization of maternal and baby wellness.

they could find out if prenatal metformin causes greater longevity in the progeny; earlier use in rodents is associated with greater longevity; what does prenatal do? Also, what effects on personality? Clonal mice behavior quantitative measurement.

Human longevity immunizations and one dose drugs are described at things I have written about, it is possible, although I do not immediately know of any, that some of these one dose longevity drugs could benefit women who are planning a pregnancy, or with research, women who are pregnant as they could reduce the preeclampsia risks. The paper notes, “before exposure to 3% plasma from preeclampsia pregnancies, it resulted in significant reduction in cellular superoxide production, normalization of mitochondrial functioning, and reduction in inflammatory influx”, so, noting that preeclampsia pregnancies have circulating chemical nonoptimalities it is possible that immunizing against these nonoptimal chemicals could benefit mother, fetus, and baby.

What might be a longevity peptide at Reishi is called Ganoderma lucidum peptide. Also, “ergothioneine is a water soluble amino acid that has been shown to be cytoprotective”

“An evaluation of all available clinical trials on the use of Reishi in cancer treatment was published in June 2012.

While there was insufficient data to demonstrate efficacy Reishi by itself, when Reishi was given alongside radiation and/or chemotherapy, patients were 50% more likely to respond positively compared to those given chemo/radiation alone. the results in cancer patients receiving Reishi showed the expected increases in immune cells known to enhance tumor response and stimulate host immunity.” reminds me of how RT immunocytes reduce risks from stroke. A month of pre-dosed Reishi could be measured as to wellness and cognition preserving effects after ischemia as a result of its immunosystem effects.

Polysaccharides like glucans that have drug activity could be genetically engineered into plants to benefit human beings.

Genetically engineering, or growing it on a flavored medium, to make the reishi fungus to taste delicious could cause a larger number of humans to benefit from the 9-20% longevity increase. Also, they could test it on mice, and mutate fungal versions that have the optimal dose at a fewer gram quantity of fungus, that would also make the pills more affordable. Has anybody tried putting one day’s dose in a chunk of chocolate for easier enjoyment? The cheapest mushroom powder on amazon is near 53 cents an ounce.

“The NIA Interventions Testing Program (ITP) has to date reported on four drugs with consistent major effects on mouse lifespan in one or both sexes and found evidence for significant but less dramatic effect of four other drugs. Rapamycin, started at 9 months of age, was found to increase median lifespan by as much as 26% in females and 23% in males. Acarbose can lead to an increase of 22% in median lifespan in male mice, and to a significant, but smaller, 5% increase in female mice. A third drug, 17-α-estradiol (17aE2), a nonfeminizing congener of the well-known estrogen 17-β-estradiol, increases lifespan of male mice by 19%. Lastly, NDGA (nordihydroguaiaretic acid) has been shown to increase lifespan of male mice only, with an increase of 12% in median lifespan.

Drug delivery; paracellular transport is transporting things across an epithelium by passing through intercellular spaces, “Some claudins form tight junction-associated pores that allow paracellular ion transport.[12]

The tight junctions have a net negative charge, and are believed to preferentially transport positively charged molecules. Tight junctions in the intestinal epithelium are also known to be size-selective, such that large molecules (with molecular radii greater than about 4.5 Å) are excluded.[13][14] Larger molecules may also pass the intestinal epithelium via the paracellular pathway, although at a much slower rate and the mechanism of this transport via a "leak" pathway is unknown but may include transient breaks in the epithelial barrier.

Paracellular transport can be enhanced through the displacement of zona occludens proteins from the junctional complex by the use of permeation enhancers. Such enhancers include medium chain fatty acids (e.g. oleic acid), chitosans, zona occludens toxin, etc.”

If a female mouse is pregnant with a clone of herself, and the plaenta is bypassed with surgery to connect the two bloodstreams does the pregnant mouse live longer or show tissue regeneration? In an extreme sense, if so, then a uterine blob, perhaps even a nonfetal version could have a longevising effect.

Heart transplants cause 15 years greater lifespan in ill persons. Interestingly, “During heart transplant, the vagus nerve is severed, thus removing parasympathetic influence” That suggests the possibility that modulating parasympathetic nervous system could have a longevity effect. Drug localization could reduce side effects on areas of the parasympathetic nervous system that are harmless or beneficial.

“The parasympathetic system is responsible for stimulation of "rest-and-digest" or "feed and breed"[3] activities that occur when the body is at rest, especially after eating, including sexual arousal, salivation, lacrimation (tears), urination, digestion and defecation.

some things that I have read have something to do with lifespan are dopaminergic activation, “feed and breed” (CR, enunch), digestion (morphology of GI tract and LKM512)

“As in the sympathetic nervous system, efferent parasympathetic nerve signals are carried from the central nervous system to their targets by a system of two neurons. The first neuron in this pathway is referred to as the preganglionic or presynaptic neuron.”

Suggests that like deprenyl preserves the suubstantia nigra something could localize at the parasympathetic long neurons and preserve it or grow it like (NGF, BDNF, VEGF, stem cells). Youthful (teenage) function parasympathetic nercous system could be a healthspan or possibly longevity technology.

“Its cell body sits in the central nervous system and its axon usually extends to synapse with the dendrites of a postganglionic neuron somewhere else in the body. The axons of presynaptic parasympathetic neurons are usually long, extending from the CNS into a ganglion that is either very close to or embedded in their target organ. “ Really long neurons reaching organs on an each-organ basis.

Another area of localized neuronal preservation could be the CNS connector to the vagus, “vagus in Latin literally means "wandering"), has parasympathetic that originate in the dorsal nucleus of the vagus nerve and the nucleus ambiguus in the CNS”. “Upon leaving the medulla oblongata between the pyramid and the inferior cerebellar peduncle, the vagus nerve“, “two distinct branches of the vagus, both of which originate in the medulla”

I perceive deprenyl might sort of look like dopamine, and thus concentrate at dopminergic neurons, so perhaps something that looks like Vagus nerve neurotransmitter chemicals at either the vagus or the CNS connectors to the vagus could carry preservatives or things like BDNF, NG, others; sort of like acetylcholine (or any of 30 different nuerotransmitters) connected to half a deprenyl molecule could be a vagus preservative. Deprenyl has a PEA then a nitrogen attached to an ethynyl group, so acetylcholine with a N-C≡(triple equals) on it, and perhaps a polyglycine to keep it out of the CNS, could be a bodyside vagus drug. Perhaps the ethynyl could be at the N of acetylcholine, “The parasympathetic nervous system uses chiefly acetylcholine (ACh) as its neurotransmitter, although peptides (such as cholecystokinin) can be used.[15][16] The ACh acts on two types of receptors, the muscarinic [M2] and nicotinic cholinergic receptors.”

A youthful form cardiac neuroagent or neuropreservative could cause greater longevity and wellness, “vagus nerve acts on sinoatrial node slowing its conduction thus actively modulating vagal tone accordingly. This modulation is mediated by the neurotransmitter acetylcholine and downstream changes to ionic currents and calcium of heart cells.”, “increased vagal tone (and thus vagal action) is associated with a diminished and more variable heart rate.” So along with the idea of a cardiac neuroactive or neuropreservation chemical, the possibility that regular heart rate might be beneficial could go with a cardiac Acetylcholine reducer that a drug would be better kept out of most of the body, notably the CNS. Some organisms make acetylcholine regulators, so those could be a molecule source.

I perceive I read baseline lung capacity is correlated with wellness. Could drugs that effect breathing tidal volume affect wellness and longevity? 20-33% deeper (or shallower, or more rapid, or less rapid) might be non-noticed and possible with a localized stimulant. Pulmonary (vagus?) localized deprenyl or even caffeine, or a diaphragm stimulant could have a beneficial effect.

As a result, the postsynaptic parasympathetic nerve fibers are very short.“The vagus nerve does not participate in these cranial ganglia as most of its parasympathetic fibers are destined for a broad array of ganglia on or near thoracic viscera (esophagus, trachea, heart, lungs) and abdominal viscera (stomach, pancreas, liver, kidneys, small intestine, and about half of the large intestine).”

Drugs that affect the Vagus, rather than the CNS, could have quantifiable effects on mental wellness, “Baseline vagal tone can be used either as a potential predictor of behavior or as a signal of mental health (particularly emotion regulation, anxiety, and internalizing and externalizing disorders).” Vagus mental wellness effects are also supported, “Children with more secure attachments with their mothers exhibited greater empathetic responsiveness, less social inhibition, and higher vagal tone” Breathing to calm down, and a pause before reacting to stabilize cardiac rate might be automatic with vagus drugs, “unflappable, but able to joyfully rise and run around and dance” could be a beneficial vagus drug.

It is likely there is a genetics of vagus morphology. Do those genes correlate with wellness, longevity, and personality, notably happy personality.

New drug delivery technology, “Blood capillaries are a well-known site for transcytosis,[5] though it occurs in other cells, including neurons,[6] osteoclasts[7] and M cells of the intestine.” “Transcytosis (also known as cytopempsis)[1] is a type of transcellular transport in which various macromolecules are transported across the interior of a cell. Macromolecules are captured in vesicles on one side of the cell, drawn across the cell, and ejected on the other side.”

It seems like anything that gets things through capillary epithelium is a drug transport molecule or moeity. “Pharmaceutical companies, such as Lundbeck, are currently exploring the use of transcytosis as a mechanism for transporting therapeutic drugs across the human blood–brain barrier”

Transcytosis can work on things as large as bacteria, suggesting things like nanomachines being delivered to and across cytes. “Transcytosis has been shown to be critical to the entry of Cronobacter sakazakii across the intestinal epithelium as well as the blood–brain barrier.[15] Listeria monocytogenes has been shown to enter the intestinal lumen via transcytosis across goblet cells.[16] Shiga toxin secreted by enterohemorrhagic E. coli has been shown to be transcytosed into the intestinal lumen.”, “[transcytosis] activation mediated by prolactin in the rabbit mammary gland during pregnancy.[13]”, “transcytosis is regulated positively by TSH” perhaps hormonally nonactive version of prolactin or some nonthyroid active version of TSH could be linked to some other active drug molecule.

Is there anything which exported from a cyte will increase longevity? Glutamate (of glutamate toxicity), nonoptimally glycosylated proteins, tau or other alzheimers proteins, transcytosis also exports things as well as transports through. Possibly sulfur containing amino acids like methionine, metalloproteins containing iron, or worn out organelles (noting it can possibly work on things as large as bacteria); lactic acid or lactate export could make it so people were absent feeling tired after lots of motion; effortless hiking.

GSK: Better stethoscope, Heart rate microvaries with areas of breathing cycle, it is possibly diagnostic of disease; a stethoscope that computationally combines breathing change with heart rate at microintervals could be linked to a deep learning AI that connects RSA and heart sounds with various diagnosable things, including normality or even better than well status. Micropressure sensor could record breathing microchest movements separate from cardiac sounds. Could also be GSK for amateur unsupervised patient use and upload to the cloud for longitudinal data on patient wellness; “Respiratory sinus arrhythmia (RSA) is typically a benign, normal variation in heart rate that occurs during each breathing cycle”, “RSA is frequently used as a noninvasive method for investigating vagal tone, in physiological, behavioral, and several clinical studies.[16][17][18] This can be done using electrocardiography (ECG) recording,[19] although other methods are also being developed that take advantage of the interactions between ECG and respiration.[20][15] Interpretation of RSA measurements must be done with care, however, as several factors including differences between individuals can change the relationship between RSA and vagal tone.”, “RSA is less prominent in individuals with diabetes and cardiovascular disease.[27]”

GSK: Also, a adhesive version of the RSA stethoscope could be worn all day or for several days to longitudinally measure actual stress levels of actual patients, “That is, RSA is a measurable, noninvasive way to see how the vagus modulates heart rate activity in response to stress. This method is useful to measure individual differences in stress reactivity.” Psychiatrists and general practicioners could figure out how “freaked out” people were, the amplitude, and how many minutes a day, that could be combined with deep learning AI projections of the effectiveness of various drugs and treatments. Deep AI on RSA data: Propranolol for some, others might get software based therapy, others might get different drugs.

GSK, RSA vagus well being at fetuses and likely babies, “Healthy human fetuses have a high variability in heart rate, which is mediated by the vagus.[7] On the other hand, heart rate decelerations, which are also mediated by the vagus, are a sign of fetal distress.” This might also have something to do with babies. Pregnant people could wear microsized RSA monitors to learn to do something that minimizes fetal nonoptimality. Perhaps there is a nutrient in pregnancy that is beneficial besides the maternal use of walks, software, music, or even entertainment (perhaps maternal watching of comedies, or social networking sites (particularly feel good: filtered social networking) reduces fetal nonoptimalities) Perhaps more deonstrations of interpartner affection benefit fetus RSA. Babies might wear an adhesive (or surgical glue-on) RSA to rapidly detect SIDS and possibly do something about it (mattress is motorized and can flip a sleeping baby to face-up). Making it eentsy: MEMS accelerometer (cardio, breath) and microLED size laser (breath, pulse, cardio) in a skin jewel with MEMS physical switching between configurations of a RFID tag’s conduction path could be used to inform a networked RFID reader about RSA every few milliseconds. GSK: tens of millions of babies could provide fiscal value to happy fetus happy baby RSA technology.

Beauty appreciation drug, a vagus effecting drug could effect perception and enjoyment of visuals, possibly including human beauty, “Polyvagal Theory provided us with a more sophisticated understanding of the biology of safety and danger, one based on the subtle interplay between the visceral experiences of our own bodies and the voices and faces of the people around us. It explains why a kind face or a soothing tone of voice can dramatically alter the way we feel.”

The internet comes near suggesting the vagus nerve can be highlighted and colorized with chemicals at microscope samples. It is possible that versions of these colorizer chemicals that are physiologically harmless or even beneficial (methylene blue) could be used to preferentially transport drugs to the vagus nerve. “toluidine blue”, “The dye is sometimes used by surgeons to help highlight areas” has been used to colorize a vagus nerve, but there was no mention of preferential absorption at the vagus compared with other nerves. Perhaps if a technologist, scientist or drug engineer is willing to affect several nerves simultaneously then tissue colorizers that have been modified to be harmless or beneficial is a plausible approach to drug localization.

I just read that the nucleus and thy cytoplasm have different preferences when absorbing pH chemicals, “Typically, the cytoplasm of cells is eosinophilic (acidophilic) and is stained red, whereas the nuclei and nucleoli are “hematoxylinophilic” (basophilic) and are stained blue” There are proton donors and acceptors different than hydrogen or hydroxls, so, perhaps these more nondiffusive things would cause cytoplasm or nucleus localization that is different than molecular transport channels. If there is ahrmless polyprotic acid, or some non nucleotide (PO4) these might build up and concentrate near nyucleus or at cytoplasms.

At nonhuman mammals a vagus nerve has been cut and then stiched back together, which caused partial restoration of function. A much milder treatment could be insertion of polymer very microtubes through the vagus, these could be loaded with time release chemicals like BDNF, or possibly utilized with acetylcholine placeholders or activators to decrease or increase amplitude of vagus activity.

GSK: microinserts for use at nerves where at development of the technology 3 or 10 new neurons are generated for each neuron physically disrupted with the microinsertion tube; quantitatively measure absence of net harm, and quantitatively measure net benefit. Another possibility, which I think has been studied is stem cells that are a part of implants, possibly previously researched as suture sized, these microinserts with progenitor cytes would be much eentsier. It is possible the microinserts rather than being tubular could be other shapes, and it is possible the other shapes could be “wired together” to make micropressure gradients, ro predictably, electrical gradients, or lego-nested to combine two or more chemicals into one neural location. Robotic surgery could place these lego nested multidrug insert stacks, with or without surgical glue, at various locations and tissue to provide benefit. One chemical possibility is leukocyte or macrophage repellent; if immune system cytes can be repelled from a surgery or microsurgery site it might heal better with less degradation and puffiness.

The narrow diameter and chest location suggest that robotic surgery would be more functional at implanting drugged microinserts at the vagus. Wound healing peptides, proteins and chemicals likely have been previously researched as to their effect on surgically modified nerves, so they could just possibly on occasion produce higher than normal function (upregulate or decrease with chemicals as preferred) if the nerve is not cut, just microinserted.

I may have previously written about the possibility that children can “win friends and influence people” with software practice; it could possibly be measured that teaching children to give parents honest compliments improves parent-child interactions.

Noting much of personality is genetic, and 80% of intelligence is genetic, and that 2/3 of persons with thinking centric or feeling centric style during 2019 AD were chromosomally predictable, is finding a genome that is at the 99th percentile of actually improving, and being pleased with the improvement from self help books and software a thing that exists that has predictive accuracy? Genome databases could be used to find people who are predictably most capable at self improvement and then contact them to let them know they can improve their lives.

I favor psychiatric drugs over talk therapy, but is there a genome associated with greater than 80% symptom improvement from talk therapy, that 80% approximating psychiatric drug effectiveness during 2019 AD. Psychiatrists and talk-attracted person-patients could use the person’s genome, as well as psychological and possibly neurological tests to advise persons on whether to try drug or talk methods of feeling better, as well as increasing the effectiveness of treatments for feeling better than well.

Things that could improve pregnancy, gestation, and baby well being:

Some amino acids are below median in underweight babies. There seems to be a bunch of research on this, so perhaps supplement experiments are likely, “The peripheral blood levels of alanine, homocysteine, methionine, ornithine, serine, and tyrosine were significantly lower in newborns with IUGR weighing less than the 3rd percentile than in AGA [normal weight] newborns. The peripheral blood levels of differentially expressed amino acids showed compensatory increases in newborns with IUGR whose weight in the range of the 3rd to 5th percentiles, and these concentrations were higher than those among AGA newborns, while the concentrations of isovaleryl carnitine and eicosenoyl carnitine increased with increasing weight percentile.”

Tyrosine (amino acid) might be beneficial to the fetus. Normal weight babies have 73.4/48 more tyrosine than underweight (3rd percentile) babies.

L carnitine, so possibly acetyl l carnitine, might be particularly beneficial with a food source rich in long chain fatty acids (LCFA). omega 3 EPA and DHA are LCFA, as is coconut oil.

L carnitine benefits in vitro fertilization (IVF), “Following vitrification, the post-warming survival rate of blastocysts derived from L-carnitine-treated oocytes was greater than that of blastocysts derived from untreated oocytes (42.4% vs. 24.9%; P < 0.05). In conclusion, a 1 h oocyte exposure to 3 mM L-carnitine immediately prior to insemination enhanced cleavage and improved the cryotolerance of resulting blastocysts.” Also, “These data indicated that L-carnitine supplementation during IVM (in vitro maturation) of immature BCB+ oocytes improved preimplantation developmental competence of oocytes after IVF”, also, “Effect of L-carnitine (LC) treatment on nuclear status of mouse oocytes selected by BCB test during IVML “, a table says that oocytes at IVF and IVM are slightly more than 4 times less likely to be a particular kind of messed up, and 268/205 better at metaphase II (IPMAT stage).

Carnitine could benefit other things that could use more ATP like sperm motility, which could be beneficial for one decal a month sperm releasing vaginal decals and creams a woman could use to voluntarily become pregnant with genetically advantaged or optimized gametes, “L-Carnitine was effective in improvement of percentile of motile sperms, grade A sperms, and normal-shaped sperms.” also, “With respect to sperm, it has been shown that high concentrations of free acylcarnitines are positively correlated with progressive sperm movement [49]. Furthermore, a study reported lower C2 concentrations in semen of oligozoospermic men [50]. In accordance with this finding, Busetto and colleagues reported that L-carnitine, acetyl-L-carnitine, vitamins and zinc diet supplementation has a beneficial effect on sperm concentration and sperm motility in men with abnormal spermiograms”, also, “In seminal plasma, in contrast to sperm, the acylcarnitine content tended to correlate positively with sperm concentration” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382115/

A novel higher AMU lipid moiety carnitine supplement could benefit babies, although the carnitine baby weight correlations go both ways. Large for gestational infants are published as, “elevations in dodecanoylcarnitine (C12), tetradecanoylcarnitine (C14), tetradecenoylcarnitine (C14:1), palmitoylcarnitine (C16) and palmitoleylcarnitine (C16:1) in large for gestational age infants (LGA)” However, different carnitine variations were associated with, “Also significant after correction were elevations in ALA, C0[free carnitine], C2[acetylcarnitine], C18:2[linoleocarnitine] and a decrease in TYR were also observed in infants small for gestational age (SGA) [possibly from peeclampsia]” So there could be a comparatively more beneficial carnitine prenatal supplement. They would have to see if the babies came out better with the supplement that causes Large for gestational age effects. What if this raises a 20th percentile sized infant to a 50th percentile sized infant. I do not have actual numbers, but that could cause babies to thrive more.

Acetyl L Carnitine might be something people with cardiovascular disease might benefit from avoiding, “Higher levels of the even‐chained acetyl‐, octanoyl‐, and palmitoyl‐carnitines were significantly associated with elevated risk of cardiovascular death”

Longevity technology, possibly; Senolytics cause greater longevity, notably though a completely different thing bacteria, “Hence why in lab situations, cleaning solutions are rotated. You rotate between acid, bleach (oxidizing) and alkali based cleaners” alternating things that wipe out cytes are used, that suggests that sequential senolytics that work in completely different ways could be more effective, that goes along with senolytics that concentrate at different tissues.

What websites reduce risk of cognitive impairment? “Researchers found that using a computer in middle-age was associated with a 48-percent lower risk of mild cognitive impairment.”

GSK: Noting [2fries] idea about alternating pools of water that reduce algal growth [link]:

Two phase dental hygiene:it seems plausible that a harmless antibacterial at a mouth rinse might cyclically complement a harmlessly antibacterial toothpaste. I have heard cheese prevents tooth decay so perhaps an emulsified oil at the toothpaste and some less yucky tasting ingredient from listerine could complement each other cyclically.

Then again, perhaps there is zero correlation between the number of bacteria in a mouth, the recovery time of S. mutans tooth plaque, and actual cavities. It might be a novel, potentially effective breath freshener though.

Another possibility is a morning moth rinse and an evening toothpaste, each with very different ways of terminating plaque and breath scent bacteria.

If cycling pH can be used to reduce bacteria quantity and growth then a polyprotic fruit acid like food grade adipic acid (low pH) could be at the toothpaste and possibly a flavor-tolerable high pH magnesium containing molecule could be at the moth rinse. Magnesium threonate tastes neutral or slightly pleasant and is even published as a nootropic.

If it is possible to demonstrate that a toothpaste/rinse cycle reduces cavities and unpleasant breath as effectively as brushing twice a day (Which I do not do) then this could take the place of some toothbrushing. The flavor of breakfast could be improved for millions of people! Minty breakfast cereal would be a quaint 2019 experience.

Also, there is that fruit that makes everything taste sweet, but takes 1/2 an hour to work. If you put that at the AM mouth rinse then it might have time to work, causing breakfast to be really sweet tasting.(.5B)

ATP has a pH of 6.8 to 7.4 so maybe an ultra-harmless ATP mouth cleaner at pH 6.8 and another at 7.4, or a high pH magnesium molecule, or yummy Mg-amino acid (magnesium threonate tastes mild or slightly pleasant) with could be part of a two part system

Or you could just chew some breath freshening candy that did the antibacterial breath freshening thing that complemented the toothpaste. Some people might prefer a xylitol candy treat to a mouth rinse.

(.5B)Project your own bike lanes A bicycle could have something like two laserpointers on it that projected two parallel lines ===== on either side of the bicycle. Visible to cars, this would provide a suggested zone of courtesy in a familiar bicycle-lane form.

Just like self-driving cars it is possible computers could scan traffic and construct optimal sizes of lane width or even cause it to be different colors. The computer would know what to do when there were multiple bicycles near each other.

To get the most optimal angle for the cars to see it, the laserpointers might be at a glancing angle near the base of the bicycle.

Longevity technology:

Are there any chemicals at the circulatory system that affect the length of telomeres? They could screen a library of huge amounts of different proteins, peptides, hormones, ions, and even wastelike fragments of other molecules to find out if any othe them increased or reduced telomerase and telomere length. If they reduce it, they could be immunized against, creating a longevity immunization. If they lengthen telomeres they could figure out how to make more of that endogenous circulating chemical, perhaps through gene therapy or supplements. I read about things where they measure the effects of chemicals on millions of yeast cytes, that could be an organism to affordably screen a ten thousand or a hundred thousand different circulating chemicals.

enunchs live longer, cyproterone acetate is described as chemical castration, so:[bs0u0155] Putting some other thing on the cyproterone other than an acetate is a nifty thought. Perhaps there is testis-mostly/only version of cyproterone like diacetyl cyproterone that passes the testis-circulatory system barrier (I read about it, it is kind of like the blood brain barrier but for gonads, I do not know if ovaries have them as well) but mostly stays out of the rest of the body.

Or, aromatase is an enzyme, that to my perception is mostly in the testis, you could make some cyproterone with moeity molecule that only divides to release cyproterone where there is aromatase.

GSK: Immunizing against mental illness: There is an organism that is published as causing mental illness called Toxoplasma gondii, online it says the treatment is “Most healthy people recover from toxoplasmosis without treatment. Persons who are ill can be treated with a combination of drugs such as pyrimethamine and sulfadiazine, plus folinic acid.” At the .5B (https://www.halfbakery.com/idea/Selective_20breeding_20of_20bio-companions#1261630449) it says, “Toxoplasma gondii, which infects an estimated 20-60% of humans and is linked with increased risk of madness” It seems potentially beneficial to screen 5, 9, 13, 18 year olds for that, so they can be treated early and the amount of mental illness reduced. It is even possible that an immunization against toxoplasma gondii could reduce mental illness at a population.

“Goop from alginate chitosan as well as ginger extract are both peer reviewed published as doubling the rate of healing” (.5B), I read curcurmin causes healing as well.

Longevity: does old guy sperm cause greater longevity in the children, genetically enhanced or optimized gametes could have a quality demonstration trend that also correlates with greater longevity at the children, If you have 70 year old sperm donors, which pass on really long telomeres, then you also get the data on their minds, bodies, achievements, and longitudinal measures of personality; that makes it so a woman getting gametes to get pregnant, unless she is going for a two mother pregnancy, combines two benefits, knowing how things are more likely to go and greater longevity from longer telomeres at her children, “Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age.” also, “The longer telomeres in sperm of older men suggest, however, that telomerase ‘overshoots', adding telomere repeats to the ends of the chromosomes over and above those lost due to the replication of male germ stem cells” https://royalsocietypublishing.org/doi/full/10.1098/rstb.2017.0210

Longevity technology: membrane transport molecules linked to telomerase could cause possibly orders of magnitude more telomerase getting to cytes from the circulatory system. Also, if you think of 20 different amino acid or protein specific membrane transport channels then you could attach telomerase with an enzymatically degradeable linker to each of those 20 molecules and cause 20 times more to the cytoplasm activity and 20 times higher concentrations from a plural molecule telomerase drug. Once at the cytoplasm, enzymes at the cytoplasm would divide the combination molecule into active telomerase and the other protein or peptide; GI tract bacteria, probiotics, could be genetically engineered to produce telomerase linked to 20 transport molecules, and skipping digestion could keep the telomerase absorbable. As a probiotic you could just take the engineered bacteria pill until a cheek swab said you had the telomere length of a 4 year old. Also, there are nuclear membrane transport peptides, it is possible that attaching telomerase to those would transport more of the telomerase to the nucleus to benefit the human being.

Genetically engineered yeast could also deliver telomerase directly to the small intestine, “I was fortunate to eat a bunch of dough; to my perception if you eat a bunch of dough the carbohydrates plus yeast make it past the stomach then the yeast makes lots of co2 causing a gas-passing event” So something as simple as a blob of bread yeast a few days in a row, could repair telomeres

Longevity technology: “pubmed has a record where ip mouse placenta makes mice live 1.7 times longer http://tinyurl.com/3esjygd “, “To determine the role of placenta cells allogeneic graft in mammalian longevity, the 15-month-old female BALB/c mice (n = 50) were divided into Control group (A), Short-term transplanted group (B) and Long-term transplanted many times group (C). Their placentae (at 18 days of gestation) were taken out and ground with 50-eye cell grit, and the cells were intraperitoneally injected into the mice of B group and C group three times at intervals of 10 days; then the cells were transplanted into the mice of C group many times till the time of death. The mice were evaluated by use of ultrasound-cardiogram; autopsy; score of cardia, spleen, skin, lung, kidney; histopathology; serum total superoxide dismutase activity, serum maleic dialdehyde content, and serum glutathione peroxidase activity. The long-term surviving stem cells were found to be located in many organ tissues of B and C groups' mice with in situ Y chromosomal hybridization dyeing. Median life span of B group mice was 1.7 times that of A group's after transplantation, but there was no statistically significant difference between B group and C group. Three months after transplantation, in B group, the pathological developments of significant skin, cardia, lung, and kidney were delayed; the retrogradation of heart function was attenuated; the data on heart mass index (mass of heart/mass of body), left ventricular mass and serum Maleic Dialdehyde content, and on spleen mass index (mass of spleen/mass of body), left ventricular diastolic volume, serum Total Superoxide Dismutase activity and serum Glutathione Peroxidase activity, were all in a direction favourable to B group (P < 0.05). These results were in line with the hypothesis, i. e. longevity can be enhanced to some extent by transplantation of placenta cells.” https://www.ncbi.nlm.nih.gov/pubmed/21374985 Notably, the 70% greater lifespan from injecting female mice with possibly just one of their own ground up placentas. This could be a standard treatment for women who have just given birth. It is also possible that what are called chemical pregnancies or partnerless uterine blobs, that might have a placenta but at 23 chromosomes are absent the ability to develop, could be induced without pregnancy giving women the ability to make this treatment for themselves at any time they are fertile. Also, noting the placenta is from the baby’s genome, it is possible a woman could give another family member her placenta for injection with the same amount of tolerability she experiences. So, you could freeze your placenta, then have your parents and siblings inject it when the effects were optimal, making parents and siblings live longer. They could find out if voluntary donation of a human placenta makes other primates live longer, and possibly find an even more longevizing method of administration than intraperitoneal, that I think is just a bolus in the abdomen. Perhaps three parts, intraperitoneal, lymphatic system, circulatory system coadministration could reach more kinds of tissues

Longevity technology: there is a kind of cytosis called transcytosis where entire bacteria can migrate into and through cells. It is possible that genetically engineering stem cells, or other placenta cells to be transcytosis active could get more stem or placenta cells past the capillary epithelium to beneficially go all over the body. It is possible that the transcytosis proteins engineered to be on the outside of the stem cells could be made responsive to a drug that causes them to omit transcytosis once they got past the capillary and blood brain barrier epithelium, so, like 9-24 hours after a dose, the drug would be given, then the stem cells would be active at their new location and persist there rather than continuing to move around.

This says 1/5 to 1/2 of cardiovascular disease is linked to gingivitis: https://www.halfbakery.com/idea/Breakfast_20improving_20toothpaste#1367440537

Gingivitis bacteria, which might be orderable online, ground up and mixed with copper sulphate might be a heart disease preventing immunization. Other gingivitis immunizations are described at pubmed, The vaccine targets enzymes produced by the bacterium Porphyromonas gingivalis, to trigger an immune response. This response produces antibodies that neutralise the pathogen's destructive toxins.” https://www.sciencedaily.com/releases/2016/12/161205113748.htm

Wellness technology that would cause many people to live longer: Noting It says 20-50% of heart disease could come from gingivitis and periodontal disease, if that is accurate, then $1 periodontal disease and gingivitis screening with a dollar store color antibody saliva test could be affordable and comparatively simple to make. Also, when I wenty for a checkup they screened me for more than dozens but I think less than 100 things, they could screen people for periodontal disease and gingivitis antibodies, and the computer or the physician could generate a predictive risk score based on family history and any actual illness the person might have. Then an antiperiodontal disease treatment like antibiotics could be given without further laboratory work. If that reduced periodontal disease sourced cardiovascular illness 10-40% (noting 20-50%, and high treatability) that could affect 10 to 40 million Americans, and hundreds of millions of people, eventually, as they come into the cardiovascular effect-zone, globally. HMOs would value the financial savings from prevention of cardiovascular illness. If the 20-50% numbers are accurate curing and preventing periodontal disease and gingivitis could be much less effort than changes to diet and exercise, although all three would be beneficial.

Would pulling one rotting tooth and some fragments reduce the amount of gum disease? Likely.

If the thing that says 20-50% of heart disease is linked to gingivitis is accurate, are there any supplements that heighten gum health? “CoQ10, an antioxidant that helps maintain the soft tissues in your body-including your gums. Some early research suggests that taking CoQ10 can even help shrink the pockets caused by gum disease.”, A study in the Journal of Periodontology found that men and women who consumed less than 60mg of vitamin C daily were 150 percent more likely to have gum disease than people who took in at least 180mg.”, “Studies shows that “People with low intake (of DHA) had an approximately 1.5 times higher incidence rate ratio of periodontal disease progression”. Regular intake of Omega-3 supplements is helpful in the treatment of periodontal disease and other gum diseases. Its anti-inflammatory effects effectively reduce the chances of gum inflammation, weak gum and teeth.”

Does once every 1/2 year two weeks of antibiotics do anything beneficial, on pubmed it says about peridontitis, “antibiotics, such as a combination of amoxicillin and metronidazole”, ” doxycycline, “The importance of doxycycline arises from the fact that it has higher availability in gingival crevice when compared to other drugs, 7–20 times more than any other drug.”, “Because doxycycline can be given only once daily, it makes it more patient compliant. Compliance is also favored because absorption from the GI tract is only slightly altered. The recommended dosage as an anti-infective agent is 100mg bid on the first day, followed with 100mg once daily for 21 days.”, metronidazole, “Metronidazole is not the drug of choice for treating A. actinomycetemcomitans infections. However, it is effective against them when used in combination with other antibiotics.[11] It is also effective against anaerobes such as P. gingivalis and Prevotella intermedia.[6]”, “The metronidazole–amoxicillin and metronidazole–amoxicillin–clavulanate potassium combination caused excellent elimination of many organisms in localized aggressive periodontitis” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467876/

It could be possible to immunize against immunoreactivity response, immunizing against antigens in a way that is different than a usual spontaneous immune reaction, “the following are considered to be the primary pathogens causing periodontitis:[4–6]

Porphyromonas gingivalis, Agregatibacter actinomycetemcomitans, Tannerela forsythensis

These bacteria produce an array of antigens that stimulate -pro- inflammatory cells and leads to the production of a wide variety of cytokines. These antigens may stimulate Th1 or Th2 cells.” So something that causes an effective antibody response to the crummy antigens and cytokines, without having a Th1, Th2 response could reduce cardiovascular risk even among persons with minimal dental hygiene or dentist access, perhaps at the developing world. Also, the duration of effect, the interval between immunizations could be different between immunizing against the bacteria compared with immunizing a new way against the antigens and cytokines; what if there is an order of magnitude or greater interval advantage to one kind of immunization or the other.

Does periodontal disease effect cardiovascular disease among the young, or only among those who might already be atherosclerotic? Does dental hygeine matter for younger people other than cosmetics and fresh breath?

Possible longevity technology, “Clonal contraction – Death of effector lymphocytes” at pubmed suggests it is perhaps possible to cause antibodies that cause immune disease to decrease, so if reducing puffiness anywhere at the body, or also cosmetic reactivity of skin, causes greater youthfulness then it may be possible to optimize the amount of immune response to favor only beneficial responses.

GSK: antiperiodontal disease foods that if eaten once every 7 days or even more infrequently might be possible. I read cheese reduces tooth decay, what if there were a halogenated (perhaps fluorinated) or ethynylized cheese oil or cheese protein that was 10, 100, or even 1000 times more potent than cheese at minimizing tooth decay and gum disease? It is slightly far out, but as fluoride is anti-tooth decay, it is just possible that a cheese oil or cheese protein fluoride could have orders of magnitude more anti tooth decay effect while metabolizing at saliva enzymes to be like one toothbrushing per 7 days amount of fluorine as a 2019 toothpaste.

What if there were a periodontitis and gingivitis reducing neutral to enjoyable feeling thing that clings to the teeth, and under the gums to reduce periodontitis anf gingivitis, for a while, and is absent colorization? Nutritive transparent or white metals like Mg and Ca and even Sr and, nonutritively Rb could have transparent forms, also Tin, Sn, is used on water vehicle hulls to keep things from living on them, so there is a chance that Sn is a GRAS food container approved antifouling agent for undergum and teeth application. Also the transparent In, or bismuth, or antimony, could have an attaches to proteinish calcium advantage as it is nearer the electronegative part of the periodic table compared with Ca, Mg, Sr; a variety of elements like Ga, Gd, Ge, and other more electronegative yet physiologically harmless metals might have better attachment to calcium phosphate at teeth. I had some Gd as a drink when I did a research MRI, so it is possibly it is physiologically harmless.

I may have read that the volume of lung capacity is correlated with longevity, so that suggests that completely pulmonary-well persons could possibly benefit from gradual release bronchodilators, either oral or inhaled. Some stimulants are bronchodilators, so it is possible they could see if well mice on bronchodilators live longer, as well as have greater wellness, also research on an actually enjoyable better than caffeine feeling, can sleep when you are on it, bronchodilator would heighten longevizing usage and be appreciated, a perspective above “tolerated”. Also they could do research to find out if when the pulmonary well used bronchodilators they got less pneumonia, if so, less pneumonia would save lives. It is possible that a different non-antibacterial lung activity volume heightener, different than a bronchodilator could heighten longevity and reduce pneumonia incidence; oral mucolytics, molecules with localization to the diaphragm, or even something like creatine or NMN localized (for fewer Mg dosages that are easier to take) to the diaphragm that cause greater tidal volume could have beneficial effects. Lung probiotics could produce mucolytics, or even something like possibly bronchodilating CART peptide, or something that causes the miniature villi to move mucous around more rapidly to reduce pneumonia and cause higher functional pulmonary volume, which I perceive might correlate with longevity.

Could a vaginal probiotic or other treatment heighten longevity? Noting the mouth and the vagina are each the size they are, if nonoptimal mouth bacteria can cause 20-50% of cardiovascular disease what effect, if any, does vaginal flora have on longevity and wellness? If there are humans with antibodies to vaginal mucous, possibly their own, (like oral immunoeffects) does that effect wellness and possibly longevity at the rest of the body from autoimmune effects? A $1 dollar store vaginal mucous antibody color test could let women know if their vaginal mucous was having beneficial, neutral, or nonoptimal effects. They could then use a vaginal probiotic or see a physician to move the affordable antibody color test to the beneficial or neutral range.

I read using computers makes people 48% more likely to be cognitively well as compared with cognitively impaired, and as previously noted, what are they visiting online? If it is 1/3 social networking and youtube, 1/5th email, 1/3 browsable site-ourced entertainment (theonion.com) and the rest quora.com and the halfbakery.com when measured, does the ongoing cognitive capability go up the more they comment and produce original content? Websites could prompt more comments with slightly rearranged layouts and things like eAwards, that already exist at some sites, for how many posts or comments you make. Big social networking sites could have a “grandma” setting, likely described with greater thrillingness, that is quantitatively measured as causing twice the thread comments and possibly some other heightening of original content production.

It is likely people are differently active online at different moments of the day. It is possible that morning or evening use supports meaurable sustained cognitive capability better. So noting the 48% heightening of congitive preservation it might be a simple rememberable thing to urge cognitively-at-risk people to use the internet during the morning, evening or afternoon. “I’m retired and the doctor told me to use the internet an hour before lunch, and that it’s particularly fun and beneficial to log in again after lunch to see all the responses to my things”, Also the physician might be aware that interpersonal socialization which is measured as correlating with greater wellness and greater longevity, often occurs during the afternoons or evenings, so the physician suggesting AM computing and evening live socializing might be communicating a comprehensible, very doable thing to retired persons.

Some people, like big five high conscientiousness persons, can plan things on purpose, so they might actually do something like plan or schedule comment-rich internet site visits an hour before lunch.

It is possible maintaining full cognitive function is correlated with wellness and lifespan, Perhaps if physicians told retired people to talk during screen time more people would have more cognitive capability, that they use more often, that lasts a long time, optimally always.

At a video streaming service there could be a “social” option where it automatically (possibly with AI) detects lulls in the action, and then puts conversation starters onscreen. These could of course be skipped with the remote, but could be a utilized option among those that seek wellness, enjoyment, and they frankly admit to themselves, a more lasting intellect. AI could customize the conversation starters psychological appeal around a fun quiz, like a gradually administered big five, that the viewers respond to perhaps 2 questions at a time, over a week, to accumulate a calculable profile: Party! 1) oh no! 2) pretty fun 3) glad I invited everyone to it! 4) yep, right now there is an actual party going on, here and now! or, “I want you to want me, I need you to need me, I’d love you to love me”: 1) lots of hearts! 2) kinda like a word puzzle 3)If I did not know it has a lively tune to go with it I’d think it was Jr high school love poetry.

possibly physicians could, like healthy food, promote a social norm to talking with each other during a video

I do not know but I perceive a functioning brain might also have a greater amount of autonomic nervous system effectiveness. Perhaps active frontal lobes make your cerebellum and brainstem and vagus nerves do a better job. Maintaining cognitive function is likely to contribute to a longevizing social life. A more lively mind that has the get up and go to do things might contribute some physical exercise, but I perceive that there are physiological benefits to being voluntarily and spontaneously alert, having motivations and preferences, to be functional enough to feel empathy and be kind,

1.7 times lifespan IP placenta injections paper/publication: If you hook up a placenta to a heart lung machine does it function for weeks or months giving it transportability and the ability to be administered at clinics with scheduling; Could a new mother donate her placenta to the grandmother or her mother with the heart lunch machine sustaining the placenta, giving them months to get around to the longevity treatment?

Although I have no idea what it would do they could give prepubsecent mice IP placenta injections and see if there were any advantages to the mice throughout their lives; this could popularize longevity research as I think people would like to benefit their children and if it turns out that 4-7 year olds get a lifetime of benefit from a placenta injection parents might be particularly willing to do it. Cryogenic storage of a revivable placenta, applied to, and for use in benefitting your kindergartener their entire life, could, like cord blood storage become popular, efficient, and valued

It is my perception that during the year 2019 AD that some asian cultures had animal-derived sexual enhancement products, sometimes made from things like animal genitals, my perception is that these were comparatively popular in Asia during the year 2019, and that a new, ethically sourced tissue product that causes greater frequency of sex, longer duration of sex, greater ejaculate volume, more intense orgasms, and more frequent sex at retirement age would have active commercial, advertising, and popular interest; Administering ground placenta to mice at the human equivalent age of teens, 30s 40s 50s 60s 70’s 80’s, 90s and 100s and at both female and male mice then measuring their sexual behavior could produce quantified publishable results that a mouse that lives 1.7 times as long continues to have sex in it’s human equivalent 80s, and has an ejaculation volume and time to ejaculation similar to that of a 56 year old; Mouse mating postures and their quantity could also be tracked as a kind of guide to flirting intensity and frequency. Compared with a 20 or 40 human year old equivalent mouse, the placenta injected mice have a physiological 14 or 28 year old phenotype that is likely to have more sex, more often; ethical sources of human compatible placenta, or placenta substitute could be actual human placentas, possibly voluntarily provided endometrial uterus linings that are renewed monthly, and particularly ethical, tissue culture; notably during 2019 there was frequent published development of mass produced actual tissue animal meat substitute, suggesting increasing affordability and efficacy at industrial tissue culture with a goal of producing much more than tens of millions of pounds annually.

A german chancellor received injections of fetal sheep cytes as part of a wellness treatment, suggesting between species tissue injection contact is sometimes nonlethal. Whales that live over 200 years have placentas. See if their placenta material injected into mice, and then humans, makes the mice and humans live more than 1.7 times longer. It is possible that this could lead to tissue culture growth of whale placenta without contacting actual whales. Genetic modification of whale placenta could make it xenotransplantation friendly and immunoneutral.

It is likely the research is published; the 1.7 times lifespan placenta paper mentions stem cells; has comminuting the tissue to smaller than a stem cell then making mass fractions, then seeing if any of the mass fractions extended lifespan been tested? If the centrifuged/sorted out stem cells produce the 1.7 times longevity effect without the rest of the placental tissue then the whale placentas could be swapped out with whale stem cells, possibly from any whale tissue, then these tested on mice and humans; there is published material on ways to modify tissue culture tissue to make it xenocompatible; whale stem cells, or tissue culture placentas are engineerable to be particularly well tolerated and beneficial when made xenocompatible and immunoneutral.

It is possible that as the placenta is attached to the uterine lining, the endometrium, that a comminuted uterine lining, perhaps mid or 4/5 cycle could be intraperitoneally injected into mice, like the 1.7 times lifespan mouse placenta publication, to see if it causes greater longevity. If it does then the available supply of longevity multiplying tissue, is much larger, and immediately available to almost every woman of childbearing age. It is even possible that a woman injecting herself with a comminuted uterine lining from her own uterus could experience benefit. Endometrial as well as myometrium tissue could be tested. Online it says endometrium produces stem cells, “The continuous cyclic nature of the endometrium through the female's reproductive lifetime implies that regeneration of the glandular and stromal components is likely a product of a stem and/or a progenitor (transient amplifying) cell population”, Also, noting the effect of hormones and growth factors (EGF, VEGF etc) on the uterine lining, it is possible some amount or combination of hormones or also growth factors would create the largest amount of stem cells or other longevity material at the uterine lining. Noting the 1.7 times lifespan increase paper injected the mice three times over ten days with ground placenta, it is possible the perhaps different volume dose of a 4/5 thickness nonpregnant uterine lining, once a month for 12 months could produce lifetime benefit. Also, they could do the experiment again on mice, and induce larger than normal placentas, smaller than normal placentas, 99th percentile highest amount of those hormones and growth factors that cause the proliferation of stem cells, also induced large fetus from diabetes in pregnancy, and see what different genotypes of mice with different placenta phenotypes have as an effect on raising the 1.7 times longer lifespan value from the published paper. Testing a variety of variables could cause a 2.0 times lifespan increase or higher from the 1.7 value.

Placenta on a heart-lung machine: It is likely possible to connect a placenta to an oxygenator and pump such as a heart lung machine to keep it alive and cytologically normal for weeks or possibly months. Grind up placenta and administer to mammals during the same nonischemic interval in which CPR (cardiopulmonary resuscitation) is functional, .5 to 4 minutes, as this likely causes greater stem cell survival and normal-mode form.

Although xenotransplantation has immunocomplexities, it is possible a pregnant human female researcher, proceeding voluntarily, could have a collaborating scientist grind up some of her placenta within a CPR interval of birth and inject it intraperitoneally into mice; it is possible that some of the mice could be given immunomodulating drugs like those used for organ transplants, while other mice would experience immunoactive xenobiotic ground up placenta; noting humans live many times longer than mice, if there was not immunorejection the mice might benefit and live much longer than the 1.7 times published from injecting mouse placenta into mice. That could make the whale placenta as well as whale stem cell longevity medicalization supported.

Similarly, although the species are different, perhaps varied species of mice could have between species placenta injections to find out if things like the placenta of the white footed mouse, which lives twice as long as a mus musculus laboratory mouse, causes noticeably greater than a 1.7 times longevity increase. It is possibility that some species similarity would reduce xenobiotic responses.

One thing that suggests it might be chemicals rather than stem cells is that, at humans, the placenta has fewer than 46 chromosomes, so any stem cells from the placenta might be noticeably different than usual human somatic stem cells. It might make them more effective, but perhaps finding out if they actually live and persist at the bodies of intraperitoneally injected mice, as compared with causing some reaction that then causes longevity would be beneficial. It is possible stem cells with less than 46 chromosomes might be resistant to concerns some people have about abnormal velocities of tissue growth.

It is possible I might think of a longevity technology or another technology that benefits human beings,

prosocial computer activities, which could possibly be scripted like movies to contain sufficient user enjoyment to get people to repeatedly voluntarily use the software, could feature Assistance environments, where people could become fluent in associating that environement with a kind of beneficial assistance they could provide. This could be simultaneously utilitarian, “If we are able to vividly imagine helping someone, then we think we're more likely to actually do it," said Young, "Imagining the scenery surrounding the situation can also prompt people to take the perspective of the people in the situation who need help, which in turn prompts prosocial action” https://www.eurekalert.org/pub_releases/2019-07/bc-tbp071119.php So that suggests that a high school student using a simulator to actively assist others in a photorealistic office environment is more likely to effectively assist co-workers, causing better things for the co-worker and incidentally causing the high school student to have practiced skills that will cause others to value her and prefer to keep her around, promote her, and pay her more. It is possible that people could get photorealistic practice assisting children, causing them to be better parents. A mechanism like a mini-drone could fly through a person’s dwelling, then the photorealistic environemnt would be of where they live, and the people the practice assisting could be the people they live with. Perhaps 2 or 3 hours a day could practice a parent into being a more prosocial parent, or a child into lifting their siblings emotions and mindset possibly from good to awesome. It is also possible people could practice assisting single mothers, causing more frequent, more beneficial assistance to actual single mothers. In the United States in 2019, a tranched data view suggests 96.2% of people were employed (3.8% unemployement rate) so linking prosocial behaviors of assistance to photorealistic employment environments could benefit more than 9 out of 10 people. The article that talks about how practicing an environment can also practice altruism does things with fMRI of brain regions and uses TMS to interrupt processes to figure out things, so the photorealistic assistive environment having an effect is kind of suggested; “suggests that imagining and remembering scenes of helping a person in need increases intentions to help”, “It seems our willingness to help may be guided, in part, by how easily we can construct imagined and remembered helping episodes.” They could see if it works on romance as well, when a person imagines talking to their romantic crush, or asking them out, or composes a text in their mind, does the intention, and perhaps the action, or romantic communication happen? If it does there could be software that improves people’s romantic lives with prompted imaginings.

Benadryl or other immune calmer with a polyglycine or a hydrophilic group on it so it does not pass the blood brain barrier and relieves itching, hives, and immunoreactions without causing sleepiness. There is a slight chance that bacteria or yeast grown in benadryl would be modified to be hydrophilic while partially metabolizing.

Some studies link microRNAs to longevity, these could be made with gene therapy, such as on the liver, or even photonically activateable at the dermis to adjust amount, and then have some effect at the circulatory system. Frequently mentioned improvements to nucleotide/amino acid drugs here are: varying electronegativity, lipophilicity or hydrophilicity, attaching a cytotransport moiety like a peptide or protein, attaching a blood brain barrier passing moiety like aceytl, diacetyl, ethynyl, or chlorophenoxy, and transcytosis proteins or peptides to get the drug to travel past the capillary epithelium.

GSK (.5B):

Noting [2fries] idea about alternating pools of water that reduce algal growth [link]:

Two phase dental hygiene:it seems plausible that a harmless antibacterial at a mouth rinse might cyclically complement a harmlessly antibacterial toothpaste. I have heard cheese prevents tooth decay so perhaps an emulsified oil or cheese protein at the toothpaste and some less yucky tasting ingredient from listerine could complement each other cyclically.

Then again, perhaps there is zero correlation between the number of bacteria in a mouth, the recovery time of S. mutans tooth plaque, and actual cavities. It might be a novel, potentially effective breath freshener though. P. gingivitis could be another bacteria to measure.

Another possibility is a morning mouth rinse and an evening toothpaste, each with very different ways of terminating plaque and breath scent bacteria. That way morning breakfast tastes OK rather than toothpastish.

If cycling pH can be used to reduce bacteria quantity and growth then a polyprotic fruit acid like food grade adipic acid (low pH) could be at the toothpaste and possibly a flavor-tolerable high pH magnesium containing molecule could be at the mouth rinse. Magnesium threonate tastes neutral or slightly pleasant and is even published as a nootropic.

If it is possible to demonstrate that a toothpaste/rinse cycle reduces cavities and unpleasant breath as effectively as brushing twice a day (Which I do not do) then this could take the place of some toothbrushing. The flavor of breakfast could be improved for millions of people! Minty breakfast cereal and surfactant flavor disruption would be a quaint 2019 experience.

Also, there is that fruit that makes everything taste sweet, but takes 1/2 an hour to work. If you put that at the AM mouth rinse then it might have time to work, causing breakfast to be really sweet tasting.

Longevity technology:

Longevity gum, “More than 100,000 tons of chewing gum being consumed every year.”, of cavity preventing xylitol gum, “dentists from all around the world recommend daily ingestion of up to 5g of xylitol (around 9 mints or 3-5 pieces of gum per day” So if people chew five pieces of gum per day, 1825 pieces a year; 730 million or 1 billion gum chewers is plausible at a little over 10% of 2019 global population, and at 1825 pieces a year that is a little less than 2 trillion sticks of gum a year, at 20 pieces of gum each 24 hours per chewer that is 8 trillion pieces of gum. At a one cent premium per piece of longevity wellness gum that represents 80 billion us$ annual revnue from longevity and wellness increasing chewing gum.

AEDG chewing gum, also if a levo and dextro amino acid version of AEDG is found to be longevizing and wellness causing then AEDG could reach the GI tract for absorption.

Lithium at gum: Lithium in the water supply is correlated with people living longer, and makes laboratory nonvertabrates live 9-20% longer. If a flavor neutral or yummy lithium gum additive can be found, which could possibly arise from linking a 10,000 times sweeter than sugar sweetness peptide to lithium at a stomach dissolvable lithium chelator molecule, then at 5 sticks a day, and 5 mg of lithium per day, then 1.001 to 70 mg of delicious combined lithium/sweetness peptide/chelator molecule would be at each stick of gum.

Also, they can put anything, at perahps 200 mg at liquid center gums like chewels.

Some chewing gums may already have a peptide/peptone/protein component. calcium casein peptone is a texturizer at chewing gum, “at a use level up to 5% wt/wt”

Production of beneficial drug peptides from milk (casein) and grain (gluten): Modified proteases like trypsin could make different digestion products, some of which are drugs. Genetically engineered organisms would make the new proteolytic enzymes with customized products, which would then turn other things into beneficial medical peptides affordably. This brings Genetically engineered production’s product affordability to natural products.

Even more affordable than engineered enzymes: plants that make modified gluten with trypsin or pesin dividing regions that repeat, with a peptide of value between them: Also, as plants produce glutens, it is possible that producing Genetically engineered organisms with the sequence (trypsin or pepsin cleavable location) -peptide of value-(trypsin or pepsin cleavable location): as the peptide-of-value-polyrepeat at genetically modified gluten could produce a highly affordable source of beneficial peptides.

Modifications of gluten to produce valued peptides released from digestion with ultraffordable already available bulk trypsin or pepsin:As a system the technologist would just swap in the amino acid sequence of interest at the -peptide of value- location at the genome. During about 2005 AD the barley lab I worked at would get about 3 successfully genetically engineered plants for every 100 prepared (embryo sliced, soaked in transfection liquid, agar placed) barley embryos suggesting immediate rapid production of over 200 different versions of gluten with different -peptide-of-value- per researcher per year using very simple technology I was able to use with 1 hour of training; the technology I used likely has transfection efficiency and hourly production with new variant protocols that are 10 or 100 or even 1000 times more productive from automated slicing and multiwell plates.

It could be nifty if taking a protein with amino acid (peptide-like) sequences that already have bridges (like S bridges or different bridges) and then putting something like a trypsin or pepsin-division sequence at the four corners of the bridge :-:, would then produce a variety of different customizable bridged peptides easily and reliably; they could even make an enzymatically attachable spacer amino acid string of genetically variable length to place between the two bridge sides like n or n that would predictably provide the right distancing of briding amino acids to favor amino-acid bridging. This likely already exists.

Can a trypsin or pepsin (notably a chemical variant that does not interact with the protein source, like milk, until the hydrogen ions in the stomach modify the trypsin molecule) be swallowed with a food, like a trypsin or pepsin milkshake, to produce a biologically active peptide in the stomach or even other parts of the GI tract?

Casein, the 80% of milk’s protein protein is processed like, “manufacturers combine casein with calcium hydroxide at high alkaline levels and dry the protein” So could a non pH/pOH molecule like a carbonium ion, a methyl ion, or an ammonium ion make a novel protein chemical, that possibly with enzymatic digestion becomes a beneficial drug; sort of like casein with ammonium makes a bunch of c=c-c=c peptides that have ammoniums on them, thus looking sort of like metformin, a biguanide with numerous c=c, That goes with preconcentration, predigestion protein sources with lots of gaunidine could produce metformin function-similars with ammonium ion (pNH3/pNH2) treatment. This could also be used on digests of the protein gluten.

At casein as well as gluten they could screen every n sized group of peptides available from a library of possible published custom digestions of the protein (producing like all 7 mers, all 40 mers etc) against activity databases to see if any of them are drugs, they could also massively parallel make molecular receptor attachment models of some amount of casein’s N possible truncated peptide constituents to find new drugs that could be made from casein or gluten.

Opiod peptide from digestion of milk: a 3 (H-Tyr-Pro-Phe-OH) ,4,5,6, or seven-amino peptide (H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH) like beta-casomorphin-7; perhaps some opiod peptides are actually enjoyable, which are also minimally harmful, perhaps from localizing at only particular brain regions like the nucleus accumbens; It is possible that nonCNS opiod peptides relieve discomfort without having cognitive or behavioral effects. I perceive just putting a hydrophilic lipophobic length of, or external hydrophilic or lipophobic tertiary structure outer layer of amino acids or a polyglycine length on a peptide will keep it on the body side of the blood brain barrier, so that could be a thing that relieves discomfort or could aslo provide anesthesia.

A map, possibly constructed with positron emission tomography, or other approaches, of a screened library of which peptides concentrate at what brain regions, as well as what body regions, and an immunocolorization map (or niftier technique) of peptide localization at each cytotype and tissue type would be beneficial to the creation of beneficial drugs, notably those producible from gluten digests and probiotics and gene therapy as well as possible germline modification. Nootropic: numeous nootropic peptides are described online and at the scientific literature, https://ultranootropic.com/ ,would vasopressin, thymosin beta 4, semax, noopept, as well as many other peptide variants that only localizes at the frontal lobes improve cognition and memory and other cognitive things without effecting emotional capability (limbic areas) or bodyside functions (cerebellum, brainstem)?

Noting CNS effects on longevity, screening all nootropic peptides to see if any of them are also longevity producing peptides could find new longevity drugs, as well as amino acid sequences that van be function mimiced with peptide mimetic drugs to produce completely new lifespan lengthening drugs.

also, “Casein peptides are used for high blood pressure, high cholesterol, anxiety, fatigue, epilepsy, intestinal disorders, cancer prevention, and stress reduction”

Could casein be used as an ion transporter to different cytotypes?

polyprotic acid, or a polyhydroxyl base

s from changing something like “sodium (salt of) Also, they can put anything, at perhaps 200 mg at liquid center gums like chewels.

Do any oligosaccharides (like sugar mini-polymers) have drug effects? Are any of them longevity or wellness effects like polyribose might have, polyribose molecularly sapced NR or NMN that turns to NMN at cytoplasm, as a possible enzymatic or some benefit to the brain as a food, or fostering beneficial probiotic growth,

Previously described are possible artificial colors that heighten wellness or longevity to be used as food additives. c=c-c=c-c=c structures are frequent at some colorizing chemicals. Also, a longevity version of bright yellow B vitamins could be possible.

Microsugar lancets like at applique needlesless drug delivery could have some activity at gum. That suggests a pack of gum could immunize against atherosclerosis, perhaps a dose per decade, or even a dose per century.

A month of gum chewing with highly localized, less than than mentally perceptible effects on feeling normal, senolytic could be a one month longevity treatment.

Although candy with immunoactive material at microlancets could also do immunizations, it is possible swallowing immunobeneficial or other longevity technology gum could be beneficial.

AEDG linked to carbohydrates; lithium linked to carbohydrates, ribose linked to AEDG could concentrate AEDG at the heart, providing benefit.

AEDG linked to lactate or lactic acid could concentrate at the brain, causing benefit; as a minute amount at food, gum, or candy, concentration of AEDG at the brain could provide benefit, notably though AEDG has something to do with pineal gland chemicals, so brain concentration could permit lower doses, be more likely to provide projected benefits, possible enhance or otherwise effect fertility (50% greater conception rate from melatonin at IVF)

NGF and BDNF heightening 2 amino acid peptide, noopept, “In animal studies, Noopept has been shown to stimulate the expression of two important cognition-related chemicals, Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).”

Could those two amino acids at noopept, proline glycine, or any other nootropic peptide, be used when attached to other drugs cause high utility brain localization, “Brain-Derived Neurotrophic Factor (BDNF) has a similar role to NGF but is primarily active in the hippocampus, cortex, and basal forebrain, areas of the brain that are vital to learning, memory, and higher thinking”, also, “readily crosses the blood-brain barrier”, so attaching 2 mer (prolyl glycine) noopept to 3 mer opiate peptide (Tyr-Pro-Phe) making 5 mer pro-gly-tyr-pro-phe as a brain concentrating opiate peptide?

Proline-glycine could be an effective way to get numerous other drugs to pass the blood brain barrier, perhaps phenibut-Pro-Gly could work at orders of magnitude less milligrams per dose, and it is also possibly Pro-Gly causes drugs to pass the ovary-blood barrier as well, improving fertility drugs and possibly making contraceptives even more affordable on a $/Kg manufacturing basis.

Protein Kinase RNA-Activated inhibitors, or PKR inhibitors like C16 are peptides described online as causing new path learning after one session as compared with several sessions for unmedicated mice; could PKRI be used to localize other drugs to the brain areas that cause the “one training session works as well as several” effect? CART peptide linked to PKRI is one possibility for a new nootropic that also makes learning with many fewer examples or less practice duration possible. Even linking Pro-Gly (noopept) which increases BDNF and NGF to PKRI like C16 could cause those rapid-learning neural areas to grow causing lasting increases in intelligence. PRKIProGly can be constructed and ordered online.

Are there any peptides that pass through cartilige and joint tissues rapidly, these are different than “blood brain barrier”, but if there is any preferential transport there might be peptide that does that at joints; chondrotoin, MSM, hyalonuric acid and others could all be linked to such a joint transport protein. This could also heighten migration of other drugs. This would treat or prevent some joint decay, causing more youthful joint form and usefulness.

Genetically engineering a plant that treats schizophrenia and psychosis: There could be a peptide, findable at a library of less than 576 two mer peptides that specifically effecs 5HT receptors, Latuda which functions only at HT2 receptors and is absent effect on D1,D2, orther dopamine receptors, causing fewer side effects, could perhaps have a functionalike peptide, and then the peptide engineered into plants, brewing yeast, yogurt, vaginal probiotics, and oral probiotics, making antipsychotic medication grwoable and able to reach more than 70 million people globally. Of the Pro-Gly two amino acid noopept, online it says, “Noopept modulates the activity of both AMPA and NDMA receptors”, so they could screen a combinatorial library of all the 2 unit peptide combinations of 24 different peptides, which is near 576 different peptides on 8 mice each, to get p<.05 at behavior change, like nonpsychotic begavior, and immunocolorization mapping of the brains and bodyside nerves to see which peptides caused localization at dopamine neurons, much the way Pro-Gly concentrates at AMPA and NMDA neurons. Also, as serotonin neurons have many published activities these serotonin active or also serotonin neuron localizing neurons could have numerous beneficial drug effects.

Although noopept Pro-Gly is functional at 10mg oral dose, could a leve-dextro version of the amino acids make it omit being digested, causing a nootropic doasge in the micrograms?

Similarly, could a levo-dextro version of opiate peptides omit being digested thus causing microgram functional dosages? Also, do opiate peptides work more enjoyably if snorted or vaginally applied, or made to be a buccal absorption alginate gel mouth coating?

A variety of ribosomal activity nootropics that might, or might not function like PKRI C16, Protein Kinase RNA-Activated Inhibitors,“What makes PKR inhibitors an EXTREME example is how it works. It essentially disables a security feature of the brain that helps to prevent viral infections” suggests the possibility that either genetic material reaching ribosomes omits a prescreening of some kind, or that the ribosomes work more rapidly, or that tRNA availability goes up,

Longevity technology: Dastinib with querectin are Senolytics that benefit the brain:

The senolytic: is described as, “Senolytic treatment of AD mice selectively removed senescent cells from the plaque environment, reduced neuroinflammation, lessened Aβ load, and ameliorated cognitive deficits. Our findings suggest a role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD, and a potential therapeutic benefit of senolytic treatments. “dasatinib and quercetin (D + Q), can selectively eliminate senescent cells from pathological tissues”

At mice, the senolytic dose was 12 mg/Kg of dasatinib and 50 mg/Kg querecetin, oral gavage with PEG/saline vehicle; so perhaps 70 mg per day of D for a human, utilizing the 1/12 mouse dose thing, and 350 mg of querecetin per day. Dasatinib is prescribed for 12 months or possibly longer as an anti-cancer drug, but the senolytic dosage duration at the mouse experiment is 9-10 days. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605052/

Dasatinib causes mice on an 11 week long dose to be better at learning motion pathways, at (youngish) 3.5 month old mice, rigged to be messed up, “In peripheral organs, partial elimination of senescent cells (~30%) is sufficient to restore tissue homeostasis and function in disease models and during aging7,29,30. We next determined whether longterm intermittent senolytic treatment could ameliorate Aβ plaque pathology and/or improve cognition in APP/PS1 mice. Beginning at 3.5 months of age, female APP/PS1 AD mice were treated with either D + Q or vehicle once weekly for 11 weeks (Fig. 5a). Hippocampus-dependent spatial learning and memory were evaluated by testing the mice in the Y maze immediately before, and at the 6- and 11-week treatment time points, and mice were also tested in the water maze during treatment week 10. Mice were euthanized at 11 weeks and their brains processed for biochemical (one hemisphere) and histological (the other hemisphere) analyses. [and then it says] Compared with vehicle-treated APP/PS1 AD mice, APP/ PS1 AD mice treated with D + Q performed significantly better in the Y maze at both the 6- and the 11-week time points (Fig. 5f). In the water maze tests, D + Q treatment enhanced memory acquisition (more rapid learning of the location of the hidden platform) and memory retention in the probe trial” Notably at a graphic at the paper, dasatinib with querecetin caused large but then identical learning effects; at day 4 of cumulatively learning a pathway finding task the drugged mice were approximately 62% better learners, but at day 5 they were identical.

At a different paper, “senolytic therapies could be administered intermittently, serving to reduce the senescent cell burden by treating quarterly or even annually, which minimizes the risk of side effects”, “Treatment of mice with dasatinib plus quercetin (D + Q) improves cardiac ejection fraction and increases vascular reactivity in old mice after a single, 3 day treatment course [30,34]. In addition, D + Q treatment decreases vascular calcification and increases vascular reactivity in hypercholesterolemic, high fat diet fed ApoE−/− mice after three monthly 3 day treatment courses”

They could see if a different chemotherapeutic drug, nilotinib, that works on the same kind of cancer as dastinib is a beneficial senolytic, possibly with nonoverlapping activity at different body cytes or body tissues.

Localization peptides or proteins attached to senolytics like dasatinib could cause even greater benefit. Pro-Gly could cause brain concentration, noting that dasatinib is published as heightening learning ability it is perhaps beneficial to have a senolytic reach the brain. Chondrotoin or MSM molecular moeity on senolytics could cause greater joint youthfulness function, reduce immunoreactivity and sequelae; the cytotypes senolytics remove are published as linked to bone-joint illness, suggesting senolytics could produce younger phenotype function at bones and joints.

Fisetin is a senolytic, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ “The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit.” as well as, “chronic administration of fisetin to wild-type mice late in life improved tissue homeostasis, suppressed age-related pathology, and extended median and maximum lifespan”, “This result, similar to a recent report on the combination of D ± Q, is the first to document extension of both health span and lifespan by a senolytic with few side effects, even though administration was started late in life.”,

Dose: “mice were fed Teklad 2020 chow (Envigo, Madison, WI) prepared with or without 500 ppm (500 mg/kg) of fisetin (Indofine Chemical Co., Hillsborough, NJ) by Envigo. Co. (Tampa, FL). For oral administration of fisetin, mice were dosed with 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10% ethanol or vehicle only by gavage.” That represents 7 grams of fisetin every 24 hours at a direct, non compensated for mouse size dose, or 583.3 mg every 24 hours at a compensated mouse dose. At the fisetin placed at food, “diet with or without supplementation with 500 ppm (500 mg/kg) of fisetin, ad libitum (approximately 60 mg/kg fisetin per day). The mice were exposed to a fisetin diet intermittently from 6 to 8 then 12–14 wks of age” which could be communicating that each Kg of mouse (that is a lot of mice) got 60 mg of fisetin, so 4.2 grams per day, without mouse division number, or 350 mg per day at the mouse dose equivalent convention number. On ebay, fisetin is $22 for 10g.

At the paper, 20 micromolar fisetin has twice the cytonumber reduction as 5 micromolar fisetin at cultured cytes treated for 48 hours, and the difference in messed up cytes goes from no effect at absence of drug to 1.1/.5, or about 55% reduction of messed up cytes at 20 micromolar.

A different graph displays fisetin at cultured cytes’ senolytic activity as 1.3/.4 or 69% reduction in senolytic cytes.

They measured the senolytic activity of 11 different chemicals, fisetin at 69% was more effective than curcurmin as a senolytic at about 50% https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/

It is possible that sequential or simulataneous senolytics could benefit survival and promotion of youthful cytotypes, so curcurmin with fisetin, or at a sequence with each other could be beneficial. Taking them simultaneously could possibly work better as it is possible the nonoptimal cytes express immunoattractants while processing senolytics, and doubling the amount of immunoattractants or simultaneously producing different kinds of immunoattractants could cause greater immune response that removes nonoptimal cytes.

Notable for fisetin in food compared with once a day oral dosing, fisetin has a plasma half life, so keeping plasma levels high and steady could be beneficial as the food only had 350 mg in it, compared with the 583 mg in the once daily dose, I do not know if they had identical senolytic activity yet though.

If a human eats .5Kg of carbohydrates that is 2000 calories, and at mouse dose would have 250 mg of senolytic fisetin, suggesting the 583.3 mg a day dose is better, noting at cultured cytes doubling fisetin concentration doubled senolytic acivity. also, at a different paper dasatinib was more effective at higher doses.

An immunization could have one of the effects of senolytics, “Senescent cells can develop a senescence-associated secretory phenotype (SASP), consisting of pro-inflammatory cytokines, chemokines, and extracellular matrix-degrading proteins”, immunizing against extracellular matrix-degrading proteins could cause greater tissue functionality longer, and senolytics are researched as causing greater wellness and younger phenotype. extracellular material might be particularly reachable with antibodies. It is possible that as some immunizations last as long as a person, immunizing against extracellular matrix degrading proteins could be a one dose lifespan increasing and wellness increasing immunization, possibly functional at farther than postpubertal ages even when given to a child, during the period when people routinely get immunizations and parents highly prioritize immunization activities and coverage. It is also possible that “matrix degrading proteins” have an effect on dermal cytes and structure, which I perceive I read have something to do with the word “matrix proteins”, that causes this possible longevity wellness immunization to also be a beautification and youthful appearance sustaining possibly one dose treatment, heightening popularity and voluntary use. The other chemicals mentioned, “pro-inflammatory cytokines, chemokines” could also be immunized against to benefit longevity, wellness, and phenotypic youthfulness; I pereive there are a number of these cytokines and chemokines, so a list of which have the highest mass/volume concentration both at the circulatory system and outside, right next to the cytomembrane at the intracyte space, and then immunizing against those, could concentrate effectiveness although cytotype and tissue specificity could make immunizing against all of them notably more effective; One benefit of immunizing against a multi digit (2 digit? three digit?) number of chemokines and cytokines is that some of them may have multidecade effective immunization coverage while others might have different immunization coverage, This partial yet long duration removal of deleterious cytokines and chemokines and matrix protein harming chemicals could actually interrupt and derail any harmful processes where the deletarious cytokines, chemokines and matrix-messing up chemicals effect each other, build on each other, or saturate body repairs, from combining or cascading each other’s effects. A person that is good at math and algorithms could look at a biochemical network, then come up with a minimum number of items to remove, at certain chemical-link distance from each other, to break a network effect, cause a different group average, or modify the persistence of an emergent effect, sort of like whats the fewest steps to wipe out a deleterious eignevalue? Immunizing against that group of chemokines, cytokines or matrix-protein messer-uppers could do that math, causing greater longevity, wellness, healthspan, and youthfulness of phenotype.

Protein or peptide linked drugs could traverse vascular plaque cytopiles to deliver beneficial drugs that shrink of remove vascular plaque blobs and cytopiles and be a cardiovascular wellness drug, “[senolytic]reduces senescent cell-like, intimal foam cell/macrophages in vascular plaques”; they could screen the 526 peptide library of 2 unit (mer) peptides formed from 24 amino acids to find out if any cause preferential traversal of atherosclerotic plaque cytopiles and possibly cholesterol coatings. lipophilic peptides could be better at traversing cholesterol coated or layered cytopiles. lipophilic peptides linked to physiologically harmless immunocyte attractants could cause macrophages and WBCs to find atherosclerotic plaque particularly attractive to glom and remove. Making a protein digest of bacterial cytowalls, then linking them to lipophilic peptides could cause the immune system’s rapid and effective response to bacteria to be directed at atherosclerotic plaque, causing greater wellness and possibly improving cognition with improved CNS circulation, as well as reducing risk of cardiovascular disease. Immunizing against cholesterol works on rabbits to reduce cardiovascular nonoptimality, immunizing against plaque blobs could remove them: also just as there are many different velocities and “brush strokes” to cleaning off a nonbiological item, different velocities of immunoresponse as well as different biochemicals to remove (immunoglom) first could be tested to find the immunocleanup of vascular plaque blobs that was most beneficial and with the least risk.

a novel senolytic mechanism with a “pick preferred candy out of a pile before getting on a school bus” metaphor: Some chemical transport channels of the exteriors of cytomembranes are possibly durably pluggable with molecules, these molecules are also consructed to have a lengthy molecular tail that the immune system recognizes and is reactive to. It is possible that deleterious cytes like the kind senolytics remove, as well as scar or encapsulation tissue cytes, as well as piled up cytoblobs at vascular arterial plaques, have greater molecular transport of some specific chemical. Then, I perceive that when a person gets a harmless viral cold, that they get symptoms for 3 days before the symptoms get better, that suggests that a 2019 AD human’s immunse system takes 72 hours to produce the antibodies to remove an infection.

Labelling many things, then using a gentle wash to provide unwell/well cytocontrast: Decorative plugs that occupy a transport channel at the cytomembrane diffuse away, with a half-diffused amount at 24 hours, so 96 hours after the labelling dose, only 1/8 as many decorated plugs are on cytes. If the deleterious cytes stared with 80 plugs per cyte they will still have 10, but the cytes that only had 6-8 decorater plugs will have about 1 or zero.

Noting that senolytics increase longevity, wellness, healthspan, and cause younger cytophenotype and tissue phenotype: a new kind of senolytic: Have the person eat or be dosed with an immunoreactive chemical that has a cytomembrane molecular transport channel plug that is like 3 to 40 times more likely to plug up a molecular transport channel at the external cytomembrane and accumulate at a deleterious cyte like the kind of cytes senolytics terminate. Noting well cytes and deleterious cytes differ as to their transport channels (senolytics are previously published as reaching their goals preferentially) Give them a big enough dose so that each deleterious cyte gets say 80 antibody-reactive plugs for every 2 at a well cyte, or even 90 antibody reactive plugs at a deleterious cyte for every 30 at a well cyte. Then give the human a big dose of the decoration (the antigen without the plug part) to activate the immune response, doing this after 96 hours of gentle diffusion washing away some of the decorator plugs, the big dose of plugless decoration causes a large immunogen response, after most of the well cytes are absent decoration while the deleterious cytes are still immunoreactive.

Also, along with the activation dose of decorator (absent plug) antigen to produce an immune response after well cytes immunoreactivity is decreased, It is possible to use the body’s apparently ordinary 2019 AD 72 hours to make an immune response to a viral cold effect, then have that 72 hour spontaneous immune response glom to and remove the decorative plug labelled cytes once 96 hours have progressed, the body has produced antibodies after the 72 hour viral cold-like process, and well cytes have only zero to perhaps 3 decorated plugs compared with 8 at a deleterious cyte. The deleterious cytes have been senolytically removed, and could even possibly be removed on a “senescent cytes have different transport channels” basis, the thing that makes it a new senolytic is that it terminates cytes like a senolytic without an external drug toxin; similarly this could be a way to treat cancer, removing some of the oncocytes. Noting that some mechanism at senolytic chemotherapeutic drugs like dasatinib get preferential effect (thus likely membrane transport) at senescent cytes, and then the senolytic drugs terminate the senescent cytes, it is scientifically sensible to think senescent cytes have different molecular transport channels, or quantities of ordinary channels.

Plugging the transport channel while attracting immunoreaction, when the immunoreaction can be times or sequenced creates kind of algorithmic numerical advantage in removing deleterious cytes. Possibly a plug that resides for just hours or 96 hours would preferentially remove deleterious cytes while using up all the circulating beginning antibodies to the decorated plugs; The decorator-plug immunoreactive cytes can use up all the circulating antibodies, that lack of antibodies causes the immunoreactions effect on well tissue to be minimized, which maintains organism well being. At some numerical versions, noting each deleterious cyte has more than 8 times as many decorative plugs on it while the well tissue only has between zero and 1/8th the sites and immunoreaction, After 8-24 hours after the 72 hours before the body makes its own antibodies to the plugs, at that 96 hour chronoregion, all the existing amounts of anti-plug antibodies are utilized and there are near zero circulating antibodies, so there is an absence of further antibody glomming action on well cytes and tissues even though the immune system has been activated, activated with the same effective intensity as a response to a viral cold.

So like 100 milligram of antibodies gets used up on the highly 8:1 decorated transport channel-blocking molecules, while well cytes have a graphical distribution displaying the number of glommable plugs as centering on just one or even zero; It would take 24 hours to make another entire 100 milligrams of antibodies, so noting the decorated plug molecules wear off before that 24 hours while the body is producing the next 100 mg, the 24 hours that pass make cause just 1/4 of 1/8th the decorative plugs to be at well cytes. The well cytes only get 1/32nd the immunoreaction cleaning dose of immune system response. Meanwhile the deleterious cytes still have a plurality of decorative plugs at each cyte, labelling them for glomming and removal.

Longevity technology:

So is there a sequencable series of natural allergens, or even easy to find and get harmless colds that can be screened, like a screenable library, to do this glom at the places beneficial senolytics are active, gently wash well cytes to experience immunoharmlessness, and also up immunocytes purposefully to terminate the labelled deleterious cytes? That would be a sequence made from preexisting viruses and allergens at the 2019 AD typical population, where a human body proceeding through that sequence actually gets greater longevity, wellness, healthspan, and youthful phenotype.

So, uh, BCG, and possibly, MAO-B receptors on blood cyte surfaces, and perhaps there is something natural that occurs at capillary epithelial cytes; could blenderized pollen, perhaps with oil to make GI tract passaging liposomes, cause immunoreaction at the circulatory system? Also what about things like mushrooms, fugu, and other species immunoreaction physiological products? Are there things like blenderized e. coli variations of particular kinds that cause varied immune response, which can be bred or engineered to be longevity, healthspan, wellnes,, and youthfulness of phenotype beneficial senolytics, because they have different lipopolysaccharides on their membranes?

Find the receptors or molecule transport channels that are at the exterior cytomembrane of senescent cytes, the kind longevity, wellness, healthspan and youthful phenotype producing senolytics effect. Optimally find external cytomembrane molecular biology characteristic structures, senescent cyte-only receptors and molecule transport channels unique to senescent cytes. Then gather a bunch of those unique molecular biology object-features, like proteins, molecule transport channel membrane protein structures, or possibly lipid raft like cytomembrane fragments with a stable, typical to living structures of a molecular biological form of the kind of deleterious cyte terminating senolytics terminate, Then screen libraries of wild-type bacteria, fungi, plants, and even virus products to find out if they effect, modify, block, cause hypertransport at, or disintegrate these molecular biology structures.

Also, a novel thing, place a bunch of the actual molecules and proteins that are the unique biomolecular structures of the kinds of cytes senolytics terminate, at a culture medium, perhaps a (1000 times 1000) million multiwell plate, that contains a wide survey of bacteria, wild yeast, and variations on what humans think of as beneficial bacteria (probiotics); possibly use micropositioning to place a zone of molecular biology unique structures, a diffusion gap. and then a bacterial growth area: this causes material that diffuses across the zone to be measurable as to its quantitative effect on the unique molecular biological structures of the kind of cytes senolytics direct their effects at; When some of the million sample multiwell plates find bacteria, fungi, even viruses hosted by human tissue culture cytes products’ or other materials that cause plugging, blocking, hypertransport amplification, or disintegration of the unique molecular biological structures of the kind of cytes senolytics terminate, then organisms that produce new senolytics have been identified and can be quantified as longevity, wellness, healthspan, and youthful phenotype producing drugs. These wild type organisms can also be bred to have much higher amounts of senolytic chemicals. That is a new source of senolytic drugs.

As a technology, an immune response generating functions-like-a-senolytic yeast beverage or yogurt, plant, or plant pollen, bscteria, or even physiologically and attentionally nonperceptible dermal bacteria, similar to a probiotic, that is a senolytic from immunofunctioning, that is the immunosensitizing bacteria, plant, fungi or even virus causes greater longevity, wellness, healthspan, and youthfulness of phenotype like senolytics do. The humans, that is person’s or people’s immune response to optimally, the organisms or ok, but less nifty as it goes with actual human sustained production of concentrates, organism material concentrates, where both and either of these causes the immune system to be sensitized to glom and terminate the kind of cytes senolytics terminate.

So, perhaps: blenderized e coli membranes, combined with cytomembrane molecule transport channel plugs that preferentially populate deleterious chemokine and deletarious cytokine export channel (efflux) transport channels, also combined with some oil to make liposomes that make it through the GI tract;

So where do the at-wild, at 2019AD society, efflux blocker molecules come from? Organisms at a culture medium with chemical travel zone and an area of chemically changeable molecular biology structures to measure the modification efficacy of each of the organisms forms is described. As another source of efflux channel blocking molecules that are combinable with immunosensitizing decorations on the efflux blocking molecule, for immunoglomming and removal, which has a senolytic function effect.

It seems like it would be possible to screen a library of naturally occuring materials and molecules,proteins, peptides,andother things, as well as genetically engineered materials like new or enhanced proteins and peptides, to find out if there are any that plug the efflux channels that are effluxing deleterious biochemicals.

It might be that to a molecular biologist this is sort of easy, like “the transport channel is n angstroms wide and w angstroms tall. Anything hydrophobic/hydrophilic you make with an angle bend, a beta sheet or an alpha helix on it will block the efflux channel of that size and form. If you make a 20 amino acid peptide tail and put iton the plugging protein, you can use an amino acid that is absent any environemental or body-wide previous immune sytem antigen stimulation, or immune system activity. Immunocytes that react to the unique 20 mer peptide, after the “immune system alerting dose” are unlikely to react to any other physiological biochemical, minimizing immunological reactions drift, thus keepin nearer optimal human, immunofunction, human longevity, human wellness, and youthful phenotype form at the human.

The technology is that if just those cytes are immunoterminated which have a bunch of efflux channels where deleterious cytokines, chemokines, and matrix protein messer-uppers are effluxed, then that immunotermination functions like a senolytic:

Gene therapy, that transfects and terminates deleterious cytes with something like apoptosis, gene therapy that produces immunoequivalents to senolytic drugs, or gene therapy that actually produces proteins or peptides that are senolytic in their own right. Technology of senolytic longevity, wellness, healthspan, and phenotypic youthfulness of form are developing. At 2019 AD, at any deleterious cyte where a senolytic accumulates at but previously did not terminate as it would more optimally do, gene therapy could be a way to get the 30% that fisetin does not reach, the 50% that curcurmin does not reach, or the numerous kinds of cytotypes and tissues that any known senolytic might not reach the cytoplasm of (cartilidge, eye lenses, osteocytes, other nonvascularized tissues).

Curcurmin and fisetin are published senolytics; could curcurmin as well as fisetin molecules with an antibody alerting moeity or tail, attached with: an enzyme endogenous to the cytoplasm that divides the curcurmin or fisetin from the immune system alerting moeity, which then travels to the outer surface of the exterior cytomembrane, which alerts the immune system to terminate the cyte that the senolytic has already localized and concentrated at. That only works if fisetin, curcurmin, andother senolytics actually localize to deleterious cytes. If they just go to allcytes, but only terminate deleterious ones, then a different technology would be the thing to make. If senolytics do localize and concentrate at deleterious cytes then putting immunoactivators on them would cause them to be even more senolytic as the immunocytes seek them out.

wellness technology: somehow leukocytes, macrophages and WBCs notice they are more effective at being an active and beneficial immune system when they travel past the capillary epithelia to actual cytotypes that provide a utility definition to a tissue (chondrocytes, pneumocytes, cardiocytes, dermatocytes, beneficial only immune responses to neurons, glia, mesentary, hepatocytes) to have a curative beneficial effect; that is they make their way past the epithelia to reach pneumocytes to engulf pneumocytes that have viruses and cure pneumonia when they do that. So, is there a chemical peptide or protein that causes luekocyctes and other immunocytes to move past, or between, epithelial cytes twice as often, twice as fast, or even travel preferntially along tissue cytes and omit a travel path that is along epithelial lined passgaeways like capillaries? Those would be drugs that multiply the effectiveness of the immune system at interacting with and vanquishing infections. Kindof like the utility of antibiotics, it could be possible to terminate twice as many infected cytes orinvasive organismsevery 24 hours, rapidifying recovery from illness and improving wellbeing.

screenalibrary,

lookfor variants at a human population, find the genetics of passing epthelia or omitting travel at epithelial separation from the tissue cytes to be beneficially immunoterminated. Gene therapy could then produce muchhigher effectiveness immune systems at the people whoget the genetherapy who then have immune function that is twice as effective as passing, or passes twice as frequetly throughepithelia. Similarly my perceptionisthe leukocytes WBCs and other immunocytes have chemoreceptors. it is possible that at humans some human immune systems have twice the ability to sense, accurately a immunomeaningful chemical or molecule; These might be much more effective at sensing things at a distance when to pass an epithelial structure like a capillary to reach an actual tissue cyte to terminate the deleterious cytes and cause healing. One thing supporting the twice as effective idea is that at other body systems human capability differences between and amongst 2019 AD humans ranges over amounts much more than twice as effective, human vision, from 20-15 to 20-30, at immunoreactivity, children and adults have notably different immune learning libraries, much more than two times different, even persons of normal mental capability during 2019 AD could have brains that were twice or half as weighty. The technology is then, find an area of the immune system, particularly rapid, affordable, and effective at being changed, where the difference betweena human withthe most beneficial versionand a median activity humanis twice the effectiveness or greater. Then amongst that list of doubled or higher immune system capability, find the capabilities that respond withgreater ability most effectively to drugs, plants or other organisms, gene therapy, germline modification, lifestyle changes, and

Possibly things like biologically originated duration of immunity from an exposure could cause some people to be ill half as often (twice effectiveness) at areas, mostly previous to the 21st century, where disease organisms were persistent at the environment. So these persons would be able to omit becoming ill twice a as long or twice as effectively as others when re-exposed.

Adjuvants. I read about vaccine adjuvants. Are there any physiologically harmless adjuvants, possibly what were known during 2019 AD as GRAS food additives? Adjuvants similar to those that are a part of vaccines; these adjuvants when taken orally cause the entire volume of the body to be more effective at beneficially developing an immune response. So basically, if a person gets athlete’s foot, taking an oral adjuvant makes them twice as effective at developing an effective immune response to the fungi, so that makes them be cured twice as fast and be half as likely to have a recurrence. It is possible a bodywide adjuvant could reduce pneumonia, saving lives, although infection frequency could just be from organism variety; also, there is research on food, lifestyle, and cancer prevention. I have not heard of how taking adjuvant pills could make it so non detectable carcinogenesis is twice as immuno reacted to, thus the persons as a population, as measured at a population, get cancer as disease half as often.

Wikipedia mentions PAMPS, “Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA.[4] Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells (DCs), lymphocytes, and macrophages by mimicking a natural infection.” things that look like cytostructures, a lot of different things have as adjuvants.”, screening large libraries of PAMPS could find better adjuvants and possibly those that if taken orally, possibly as parts of liposomes, provide beneficial systemic immune sytem enhancement.

It is possible to imagine liposomes, or artificial lipid bilayer bags, that have proteins on their surfaces causing engineerable changes in immune response, that is, being adjuvants;

Bag surface proteins could be kind of purposefully noncomplex, priming for a broad different similar group of proteins to recognize. Noting the lipid bilayer bag could be made out of different lipids it is possible lipid bags made out of really lengthy new omega 3s like C20 or C27 could be hyperdurable yet physiologically harmless or even measurably beneficial as omega-3s when they disintegrate. My perception is that some kinds of liposomes are ultraffordable to produce, sort of like: oil, water, ultrasonic transducer manufacturing.

They could screen a library of mlecules to find out if there are better adjuvants than “alum”, aluminum phosphate. Gallium is at the same row of the periodic table so they could try that. Also, noting the milligrams or possibly even micrograms of aluminum phosphate at an injection it is possible aluminum phosophate liposomes that make it past the GI tract could produce the same chemical concentration as an injected dose from oral consumption; it could have its flavor made palatable rather than tasting like alum because of the liposomes.

Also, they could find out if oral food: pickles, which contain alum, have an immunobeneficial, all-body adjuvant effect on laboratory mammals, and also do correlation studies on humans that eat pickles. It is possible there are other adjuvant foods, possibly some kind of recipe for liposomal transport of something immunoadjuvantish, so like a salad dressing, a nugget dipping sauce, a dilute milk drink, or a new kind of quantifiably physiologically beneficial margarine to make liposomes or lipid bilayer bags with and at. There is a chance that oil coated fried potatos like french fries could have a liposome producing oil-water effect, or a purposeful coating; the technology to think of though is what is at the core of the liposomal bag; PAMPS; something like “vegemite”, dried yogurt powder enzyme product (basically a bunch of bacterial cytostructures and mambranes as a heap of legos), I read activated carbon, and I think zeolite like aluminum oxide, so possibly some naturally occuring zeolite like mineral, at liposomal bags. They could also make artificial zeolite that is, imaginably many times more effective than other forms of aluminum oxide, although it might not be.

If zeolites work as adjuvants, then a variation of the food thing sodium silico aluminate might be sort of like a ceramic material that could have a different zeolite like form that could be an adjuvant.

silica gel adjuvants: Other silica materials that might have adjuvant character, be placeable at liposomes, or could have an adjuvant like aluminum or gallium phosphate or ion exchange resins dissolved in them are silica gels, it is possible silica gels have different AMU amounts of silica networks, so perhaps they have light and medium ones, ones that adsorb strongly, others that adsorb weakly, also, silica gels can absorb liquids which I perceive might diffuse out again over hours, so if there is a liquid adjuvant it might go well with silica gel with liposomal bag around it; “The hydroxy (OH) groups on the surface of silica can be functionalized to afford specialty silica gels that exhibit unique stationary phase parameters. These so-called functionalized silica gels are also used in organic synthesis and purification as insoluble reagents and scavengers.” makes custom silica gels sound like they can be tuned to absorb or adsorb custom chemicals, there is even a chance that they could do some sort of simple localization, although it seems like to a silica gel, everything they are near would be epithelium.

Another, new to me approach to an oral immunization: If silica gels that are really eentsy are placed in liposomes then migrate through the small intestine to the circulatory sytem then perhaps they meet immunocytes like leukocytes or macrophages or WBCs or some other thing that react to them as a granular particle to be engulfed, I do not know how it works, but after being engulfed a silica gel particle might diffuse out something, even a liquid, that then causes a beneficial immune reaction.

Alginate jello blobs at liposomes might be an adjuvant, “adjuvants may provide physical protection to antigens which grants the antigen a prolonged delivery” That suggests the possibility that putting alginate jello in liposomes would cause alginate filled oil-water bags to travel around the circulatory system. These might pruprosefully leak alginate, causing some amount of antigens to get alginated-attached and then get gradually re-emitted; also ion exchange resins could be at liposomal bags and even glom and then gradually re-emit biological molecules of particular masses and surface charges.

Somewhat dubious, but it is my perception there are sometimes trace amounts of blood in stools. That suggests that an adjuvant, like a PAMP, aluminum or gallium phosphate at liposomes, that dissolves or migrates through membranes at the large intestine, or just contacts the sides of the large intestine, which, based on the blood at a stool concept, might have circulatory system distribution possibilities for something like the micrograms or milligrams of something like alum that could be a bodywide adjuvant.

longevity technology:

Gene therapy technology:

It seems like a dermal dose of thioglycolate based hair remover cream that, at more minutes of activity than I think the 2019 label suggests, causes moist plasma-like exudate would be an effective, simple to dose (just calculate cm^2 dermal area to topically dose to get a particular number of milligrams or micrograms of gene product per 24 hours) gene therapy technology, then to produce even greater effectiveness, have the gene therapy modified dermis have an optically activated activateable gene or gene therapy promotor area that would make it so that you could further program and direct the dosage with laser (like blue laser pointer) activation or the application of a highly available chemical. Among these technology methods is having dermal gene therapy respond to topical materials, many of which could be available almost without effort, for example, topical tannin, which could come from a leaf poultice available anywhere there are leaves, or a pharmacy, as the person prefers, could activate all, or just a little part, or even just an easy to remember location (poultice on your elbow once a month or once a year to omit ageing) dermal gene therapy area that causes some particular healing or also wellness response, as well as a longevity increasing, healthspan increasing, youthspan increasing, and lifespan increasing chemical, or as another item, produce a voluntary behavior enhancing chemical, a mental wellness drug, a cardiovascular well being drug, a senolytic, as well as a cognitive preserving and cognitive enhancing drug, an general immunoactivating drug that causes the production of more of the immunochemicals or immunocytes that are the first to notice something like a nonenutral nonbeneficial organism at the body, and, as the research finds effective treatments, an anti-alheimers protein drug; along with those technologies listed and described new better drugs that are thought of, found, and made into dermally available, light or chemically activateable gene therapy forms abe beneficial and creatable. Like I will see if I can think of a new one, if I can then that verifies humans, that is persons, that is people can invent new beneficial medicines. How about fMRI drugs? fMRI of a various thoughts and emotions that get the same verbal or writing or software measured, psychology test quantifgied description while having different fMRI data graphics, which is actually a form of algorithmic math representation, as well as positron emission tomography representation; These identically described but experientially more beneficial ways of a brain having being, isness, content, responsive ability, cognition, feeling, resting or active ambience would be different than they were before adjustable, beneficial, voluntary and even reversible or wears-off (recoverable) gene therapy; these cognitive ways, mental baselines, emotions, and even different than the thinker things like dreams or responses to media, to the extent that although they have differing fMRI or as well as positron emission tomography graphic and math measures they have identical measured quantifications at tests, computer tests, and even a person’s self-generated written descriptions of the experience of having a way of cognition, feeling, or awareness as written by the person. Math is used to define a data space, and the data space here is, with fMRI orpositron emission tomography visual feedback there is something you can prefer, and make actual with putting a leaf poultice or light ray on your arm to make durably the preferred optimized usual way to be, that can be reversed if you like, that is undetectable to prose, 2019 AD psychology measurements, the surveyed perception of other people, measurements of productivity of any kind, or computer neural network (such as deep-learning) predictions of your behavior. You like things better, feel better, think better, emote better, and do many other things better, but it is undetectable to others. When you activate the gene therapy area, such as a light or topical material activation of an area of dermis that gene therapy causes a shift to that version of genetics that causes the fMRI or positron emission tomography math and graphics to have software create the actual biological gene sequences, that will produce your, that is the utilizers, preferred version of the cognitive direction, ambience, and experience that is preferred. You can put some leaf poultice or shine a bright light on your elbow once a year to create your preferred form or kind of happy, your preferred kind of imaginative, and your preferred kind of productivity, orderliness or tidiness. It is the “even more opposite than a P-zombie drug” that gives humans, that is persons, that is people, the ability to experience, prefer, and activate benefits which are language, AI (without digital tomography), behavioral, productivity form and amount, as well as psychologically surveyably really unlikely to be discernable or distiguishable, although of course fMRI or positron emission tomography of 3d (4d time) maps of neurotransmitter locations and activation is mathematically and scientifically modellable, predictable, and the source of new materials, ideas, content, and applications with math and science. It is just nifty to be able to make actual a preference of being, isness, response to things, mental forms, nonself-forms like dreams, as well as other attributes that are among the beneficial, all of these while, being absent the possibility of verbal, written, or nonmathematical description. This gene therapy is a way to be the thing, the more womderful optimal thing, you could not ever describe, after sampling it, and being able to reverse your activation of the newly optimized way of being. Also, as an amazing feature, any human, that is person, or people, that modified themselves this way would, with very high likeliness of nondetectability, function exactly the same in the perceptions of others. You would feel creative and happy and productive, and even when between thoughts, feelings, as well as sensations prefer the newly optimized form at the new way you prefer, yet those around you would be absent noticing any change. Along with beneficial, nearer to being a preferred optimal, change that is outside of description and discernability to others, the person, that is human, or people would like to they can also get voluntary, voluntarily durable, voluntarily reversible, gene therapy that causes perceptible beneficially experienced personal voluntary change that other people can perceive if that person, human, or people feel like it.

Is there any beneficial protein or amino acid that if gene therapy produced at the optical areas or whites of the eye would benefit human beings? I read that cataracts are treatable with some eyedrops made from an amino acid, it is possible gene therapy with one dose of instilled fluid could prevent cataracts or provide a one dose cure for cataracts when it causes the production of the cataract curing amino acid. it is even possible that halving or quartering the immunoreactivity of corneas and lenses using gene therapy would make them stay clearer longer with less surface variation. AEDG and the thymulin peptide combined make humans 4 times more likely to be alive after a 6 year interval, so an eye instilled gene therapy fluid that causes the eyes to make AEDG and thymulin could possibly be a one dose longevity, wellness existence preserving functional activity drug.

MWI technology/MWI test: