Longevity technology:
How many sequential doses of an epigenetic drug cause the epigenetic improvement? Liposomal depot, perhaps attached to an antibody that gloms it to the surface of the lining of the lymphatic compartment could diffuse beneficial drugs, although that seems complex. One possibly as is epigenetic modifying drug palmitate. I do not know if the longevity effects of 10HDA(10H2DA) are from HDAC interference and epigenetic, but if they are then taking a high dose of 10HDA once a month (or some other interval), or like 30 grams of royal jelly which has 10HDA(10HDA) for two or three days once a month could have the same or better longevity effect. There is the possibility that occasional high dose 10HDA(10H2DA) or royal jelly is actually more longevizing from being thorough and of higher activity.
One HDAC2 inhibitor is a nootropic. It is possible that one or two high doses of that HDAC inhibitor a month could
Cause greater cognitive ability.
Notably though there is another version of this. I read histone epigenetics like acetylation can change rapidly, perhaps in minutes, although the other long view also makes sense as people get epigenetics from from their parents or even grandparents. I perceive I read there is longevity epigenetics people get from their parents so a couple days of epigenetic dosing could cause greater longevity effects the person's entire life. A couple days of epigenetic modifier dosing could even cause their children and grandchildren to have greater longevity. At the nootropic HDAC2 inhibitor that causes greater cognitive ability, a couple days of HDAC2 inhibitor dosing could cause intelligence enhancement that is also passed along to children and grandchildren.
Cognitive ability genetics: the genes that the published cognitive ability heightening HDAC2 inhibitor modifies could be g (like iq) intelligence genes. SNPs, alleles, and copy numbers of those genes could be enhanced at the germline or with gene therapy to increase intelligence at humans, that is homo sapiens.
Longevity technology:
I perceive piperine causes greater absorption through the membranes of the GI tract from telling them to be more permeable. Is there anything that could be placed at liposomes along with the active pharmaceutical ingredient (ÅPI) which reach the lymphatic system to make the lymphatic membranes more permeable? It could be piperine again. That lymphatic permeability drug could make other drugs, like rapamycin, rapalogs, or other longevity drugs to be 2-4 times as effective at reaching tissues from the lymphatic system. Combined with the 2-10 times greater effectiveness of drugs that skip first pass hepatic metabolism that could make rapamycin, rapalogs, senolytics, or other longevity drugs 4 to 20 times more active and affordable. Rapamycin that makes mice live 60% longer could be just 12-14 cents a dose based on $40/gram at Alibaba.com .
GSK (Glaxo Smith Klein) has an online page where they request technology ideas. They make Tylenol and some other antipyretic pills:
ela–naproxen (ela-n) is ethynyl liposomal active transport naproxen it is active at about 7.6 micrograms. They could put a dot of it on the outside of regular naproxen pill that is enteric coated so there is an immediate action antipyretic at the stomach but it also activates 11 hours later so one pill lasts 24 hours. Another way to do it is like multiminipill contac™ with ela-n microenteric coat so it dissolves better at the small intestine after 11 hours. Another way to do it is rather than a 7 day palmitate have ela-n attached to a different alkane COOH like perhaps C6COOH
To make another, delayed dose to make 24 hours of naproxen activity, that could do 36, 48, 72 hour one pill dosing as well: Another way is ela-n of three or more types taken simultaneously where each ela-n has a different enzyme-reactive group on the ela-n with a passivating group removed by the enzyme. The enzymes that remove the passivation moiety are enzymes at the circulatory system. The first ela-n gets its passivation moiety removed first and the next ela-n gets its passivation moiety removed next like cumulatively 90 minutes later, then do this with a sufficient elan-enzyme-unpassivated-moieties to get a smooth 24 hour, 36 hour, 48 hour or 72 hour dose curve.
Years of arthritis relief from one office visit: A depot drug form of ela-n, ea-n, which I calculate as having a 7.6 microgram 12 hour dose could put ela-n at an implant (3 year nexplanon-like) with just 16.64 mg of API at the implant. Sensibly and obviously omitting the 2-4 times dosage multiplier enhancement from liposomes, ae-n could be a 33 mg or 66 mg entire API content implant. I think it is possible to make much longer lasting depot implants or even injections, so a decade of arthritis relief from a decade functional implant at one offive visit is possible.
Complementing a decade functional arthritis relief implant is putting the longevity and life preserving peptides AEDG combined with thymosin at it
A peptide humanin, as well as MOT-c mitochondrial derived peptides (MDP) that is beneficial to screen as to being a longevity peptide that anti aging things and aging things simultaneously, the crummy part is it makes old cytes make old cyte chemicals, like some interleukins, the longevity thing it does is be opposite ilgf, growth hormone and Alzheimer's amyloid, they have, as far as I know, fed it to organisms to find out if the mice live longer and if they do, how much; notably though if MDP actually causes the things senolytics do then the opposite of a MDP, a receptor passivator, or an immunization against MDP could be a longevity drug, the MDP and antiMDP could be administered to different mice to find out if either is a longevity peptide
I saw a graph suggesting longevity chemical spermidine is an acetylase (histones) adjustor, it is possible that the
Things that fill children with happiness,
CPU speakers or social companion robots could notice when adults and siblings were at 90th percentile of previously measured happiness and suggest that children interact with people like their oarents or siblings then. Timing could contribute to child snd adult hapoiness, so CPU speakers that amplify adult and sibling happiness could amplify child happiness.
Longevity technology
Sleep causes greater healthspan, wellness, and optmal amounts of sleep may have longevity increasing effects as well, they could find out what 1000 or 100 chemicals most increase from several hours of sleep, are newly produced, or are decreased from optimal sleep and find out if supplementing mice or c elegans with those chemicals increases lifespan, circulating chemicals as well as tissue specific chemicals like brain, cardiovascular system, liver and heart could be utilized, chemicals from tissue homogenates from optimally sleeping and awake primate monozygotic twins or other 8 hour sleeping mammals (cows? Horses? Pigs?) could be used
Do BDNF, NGF as well as other nerve growth factors have beneficial longevity effects or healthspan effects at non neural tissues, this could be tested at human tissue culture, age batched very elderly persons, and a BDNF version with a polyglycine, protein or other peptide attached to the BDNF or other nerve growth factor so the nerve growth factor does not pass the blood brain barrier (stable isotope verified), this could be tested at mice to find out if the nerve growth factors increase longevity, if they also increase longevity at yeast or c elegans a million molecular variants could be tested at yeast or 10k versions tested at c elegans (107 or a few hundred 96 well plates) to find a version with greater longevity increase, are there peptide nrtbe growth factors? Also, if nerve growth factors cause greater longevity this could be a gene therapy longevity or healthspan technology and could also be made part of the human germline
Marmosets are a primate that could be batched into 6 months, one year, two years, and four year prior to being previously alive groups and used to test longevity drugs and the effect of longevity drugs on progeny,
Divergence of physiochistry from that of humans approaching being previously alive: from age 11, circulatory system fluids and cheek swabs tissue samples could be used to characterized to show the gradual or sudden changes of people as they traverse the years from 11 to being previously alive, eight samples from each year of age are sufficient to get a p value, so from 11 to supercentenarians is not that many samples, the chemicals that gradually change, those that increase or decrease are then tested on c elegans and yeast to find those that lonhevize yeast or, at cumulative or sudden human physiological chemical change otherwise modulate c elegans and yeast longevity and wellness or healthspan, chemicals at the 97th percentile above at causing a change in any direction could be tested on mice,immunizations against deleterious chemicals could cause greater longevity as well as healthspan, and supplementing with beneficial chemicals could cause greater longevity and healthspan. Some of the physiochemicals may be symptomatic, others might be causative like the deleterious interleukin senolytics get rid of, a really rapid version of this study would use 9 circulatory system circulating fluids and actual tissue samples from rats or cows, pigs, or horses, identify and measure the physiochemicals, administer them to yeast then test the 97the percentile of physiochemicals that cause the greatest change on mice, if large animals are used (horses, cows, pigs) then the large animal plasma or tissues can be used as a plentiful source of test chemicals for the mice, another approach is just to get 7 discrete human year of age equivalent samples from large mammals, mass sort, or electrophoretically sort that into 700 different testable plasma fraction materials then test those 4900 different plasma fractions on c elegans (53 or hundreds of plates) and yeast to find out if pjysiochemicals from chemical change progression with age shows beneficial or deleterious chemicals, if there is an effect then that electrophoretic or mass sorted plasma fraction could be electrophoresis sized or mass sorted further and partitioned into another 900 groups to find the longevity and wellness chemicals with greater precision
Things that fill children with happiness
Amplitude, duration, frequency, priming for more happiness, shareability, links to when talking about it causes others to invite the child to other fun activities, neurotransmitter refresh interval, the time of day of the happiness producing thing effecting duration, amplitude and frequency of enjoyment
What makes tired children happy, what makes children at their personal 72 hour 90th percentile of less happy be happier? They could research these and find out what benefits children.
At the 72 hour 90th percentile local minima of happiness, which could still be happy, it could be that the child has a considered and durable preference, and they are responding from that perspective. Along with finding something that makes them happy right away, getting around their 72 hour preference, I think there an ethical duty to consider children's suggestions and requests, so a child that is at a brief or hourlong 72 hour local minima of happy because they are told they cannot go to an amusement park that weekend or have a sleepover combined with when the child is being babysat (although I like the idea of a child getting to have a multiperson sleepover with a babysitter monitoring things if the parent is busy), it is possible the adult or a social companion robot explaining things, while upholding and supporting the right of the child to make requests and have preferences could ameliorate things. The shift from the child "reacting to no" compared with knowing where the "no" comes from benefits children. Emphasizing there are reasons for adult behavior might also prompt a "things can make sense" worldview that benefits the child, although, the adult or social companion robot could also have a deeper discussion of error, stochastics, local resource effects, and how apparently nonsensical or nonoptimal things can be researched to find why they occur, or are at least predictable. Noting that sometimes finding out "actually why it happens" is either more effort than the value generated or unavailable to a person, software, or AI, and the child could be beneficially prompted to think of a new thing that could answer "why it actually happens" and the new thing even make suggestions of change. Adults or social companion robots, or CPU speakers could prompt with things like "what if there were a council of children that voted on " no babysitter sleepover" and they had veto power over adults", or "could an expert think of and suggest having a babysitter take me to the amusement park", or, " if I banked measurements of being above median at school, would that make asking to stay in bed and skip school that day be allowed? (My thought is the extra day of school could make them even higher above median, which is beneficial, things could be fun once you get to school, and there is value to living beyond 3 minute urges like staying in bed longer), so explaining things to children might sometimes move s multiminute or hour 72 hour local minima nearer to median happiness, also, The CPU speaker and AI could figure out what they were talking about and make suggestions on how it could be made possible like a babysitter being there, CPU speakers saying they have activity curricula for a toy that got a "no", or a "video chat with the friend you can't visit is almost as fun", as well as, "afterschool dance has lower fees than gymnastics, is just as much fun (AI only says things that are factual though) and you could invite your friend tiffany to do dance with you". Genetic enhancement and optimization that makes a child's 168 hour 99th percentile happiness minima still be a happy experience is beneficial.
What makes tired children happy could be researched. Along the continuum of low energy to exhausted, different things could have different effects, I support genetic enhancement and genetic engineering that makes children and adults full of energy and less likely to be tired.
Longevity technology
If people did something longevizing as an automatic response to a risk, "I'm taking extra longevity pill as long as my car has no brake lights" where the longevity gain is always higher than the risk is beneficial, social companion robots, CPU speakers or phone texts could encourage people to get the risks repaired, or change their personal habits
some longevity drugs can be taken once ever, annually, daily or other amounts just from the math distribution of available technologies. An ion based longevity technology like lithium (7% greater longevity?) Could be daily or monthly as could metformin, although an annual metformin longevity drug could be possible, figuring out why education is linked to greater longevity could find some kind of actual incremental effect on longevity where using educational software or optional nootropics is longevizing, these could be daily options that increase longevity and could "make up" for other activities
Longevity technology
Things that fill children with happiness
The duration of children's happiness might be extendable 20-200%, the fMRI of happiness at a gift or a hug could be measured and they could find out if duration of happiness at a happiness producing thing has a genetic component that would be beneficial to make a part of the human genome, germline and genetic engineering
They could screen things, like toys, events, activities and school to find the things that cause the longest multiminute or multihour lasting happiness at school, some things like displayed awards might cause multi-month greater happiness, confidence, and seeking out of further opportunities at that activity or more voluntary practice, things that are authentically beneficial to children could give awards, wearable fMRI or photonic brain scan like Deep water technology, as well as deep learning AI viewing facial expressions, vocal tone, and body language could measure duration increase of happiness
Duration of happiness of children could also go up with mid-hapiness statements that CPU speakers, robot companions, or other people make while the child is particularly happy from a stimulus, or afterwards as a reminder, software and people could figure these out.
Would looking at the literature or trying new things find a form of continuous reinforcement that causes as many retries and repeat visits to an activity as variable reinforcement? That could be the basis for a fairer, ethically consistent activity that makes children happy, sometimes physically getting blocks to fit together feels good, or easily reaching for a toy, or reinforcement at doing a well practiced dance move could be reinforcing. As could heightening numeric scores or levels at a computer amusement. It is possible fresh new activities could be thought of that always cause heightening behavioral psychology positive reinforcement like easy but mounting complexity IQ test items (which is next in a visual, word, or number sequence) and which way will the gear turn, and who is having the best time at a party (after reading party person's activity descriptions) items
Longevity technology
Enjoyment and happiness could come from a variety of activities, what makes a baby, a 4 year old, a 6 year old and a 9 year old happy likely could have differences, measuring happiness producing things at a variety of children's ages is beneficial.
Making 5 year olds happy
Things with certainty "allosourus was an herbivore" that they can learn and share might be to my perception be a thing 5 and 6 year olds enjoy, the thing that teaches these things could teach statementables that are also of interest to adults like accurate factoids about the internet or consumer reports magazine type things, or statements like "they order things like swing sets for city parks out of a catalog, I think the catalogs have less than 100,00 different playground toys in them"
The child fact statements could prompt the adult to say, "do you think they should have more items at the playground activity structure catalogs or make it like a sortable database list of most fun, or both?" It is both factual and provides the opportunity for deep discussion about when more is better compared with when advice on what is better about a wide range is especially optimal. The adult or social companion robot could say "life is full of many trillions or quadrillions of possibilities, more possibilities is beneficial as well as is asking people who are doing especially well what their preferences and behaviors are, you can have both", "let's ask someone who knows about a particular area", then a question, "what do you think we should ask?" And then the child, or the adult, might mention something from school or living that seems improvable or has a multitude of options like what after school activities are better than others, what babysitters are like and how babysitters should act, where to go on vacation, or something about options at software the child uses, or if they are into dolls, building blocks, cars, or board games, what is the funniest thing to do with that toy, then they send email to people that know. At their question, the adult writes the email the child speaks if the child has not yet learned to write and reads the replies.
Props could make children happy at the context of imagining a scenario where the prop is used, or imaginatively imitating a person that would use that prop, like having a savings bank, waving it around, and speaking as if they were a banker, or an adult that encourages saving, or a person with a unit of money (all the money in the bank) talking about swapping the bank's value for something beneficial.
Children could say I'm imagining that" then children can say anything while being honest "I'm imagining that if you leave your favorite book open to your favorite page the ideas will fly out and visit other people" "mom's car already talks, I'm imagining it talks about other cars and says (things) "
Things that fill children with happiness
Longevity technology
Do other molecules that build up muscle mass besides mTOR and HGH cause different longevity, they could find out if decreasing a variety of anabolic receptors has a longevizing effect
Do things that are catabolic or smooth muscle decreasing have a longevizing effect, I have heard about this with other muscles
What is the most common genetic ancestor between all mammals, things that longevize age-batched groups of that mammal could have
There is a lizard that can detect light with its pineal gland, any extra chemicals or peptides that produces could be screened for longevity effects, noting AEDG Epithalon is a pineal peptide
The peptides and proteins that reach the circulatory system when a person experiences romantic limerance (excitement) as well as spring could be mood lifting as well as longevizing noting what I perceive I may have read about young new romantic partners increasing healthspan, perceived or actual wellness and longevity
Does glycine or other amino acids with a silicon atom or a fluorine atom taste sweet or more strongly, the variations that do might have higher affinity for receptors, thus be part of better peptides
Electrical engineering
Have electrical distribution networks switching stations modularized (they already are), and optimized to the fewest necessary components ( they already are), and made of the most affordable materials possible while still being highly functional, optimally more functional, the capacitors could be made from
PCBs polychlorinated biphenyls, could they be milder if they use half as much with one that has higher dielectric constant, or an emulsion with a high dielectric material, or at transformers, if an engineer could use any material what is the least size they could be, like cobalt and nickel laminar electrodwell things, silver wire, and cooling, what is the eentsiest superconducting transformer
Things I don't do:
Gold with cobalt blue
Art
how about a wig on a van De graaf sphere full of electrons, unfurled? Or a petri dish on a van de Graaf generator with colonies on it and calcium ions, whenever you come near it the electroporation and Ca++ cause genetic engineering, or a big puffy HOMO molecule of 10H2DA and longevizing alpha 2 estradiol
They could use positron emission tomography and deep learning software that finds the thing that most activates beauty areas of the brain and the nucleus accumbens dopamine and GABA neurons and then makes beautiful molecules shspes and display those and title it, "What does it do", they could also screen the million most beautiful molecules and find any that had pharmaceutical effects
A statue of a mouse llifting its head, doing actual happy mouse postures, looking up, and have Thank You written on the plaque the mouse statue is on
A plaque that says, "The government has been good to me but I am still a libertarian, they have missed out on so much" § And a big piece of cheese, like a round with a slice out of it, with the edges of the slice decorated with images, from laser engraving, that are round, soft, swirly, and deep learning AI screened highly beautiful.
Deep learning AI and brain scan most beautiful images on circular tiles and )( shapes to tesselate them, the visitors make their own compositions, images of people, trees, and nature scenes and domestic dwelling scenes are also at the tiles
What if deep learning AI with brain scanning finds that there are 3-4 distinct human appreciation of beauty types, there are those images that appeal to most, but for highest experience specialization would be utilized, make those separate images and call it "3-4 kinds of beauty"
Water is often beautiful, make a 3D SI screened more beautiful than the first 24 pages of a search engine results on beauty and then have people view it
Wet look things might be especially beautiful, take ordinary things then wet look and AI deep learning beauty enhance them to make images like the exteriors of houses and grocery aisles and city streets and children, and nudes, and landscapes, ordinary things
Have people online rate with slider bars ----------|--- the amount the 2000 more AI beautiful images that make them feel good, then display those
Have a plaque that says "go to college, you will be happier, meet better romantic partners, live longer and learn things" then have a fairy lit upon one corner of it looking thoughtful
Fan fiction
Kirk and Spock took the surplus phaser and set it to explode, then they tossed it in the water, big splash! Just two guys having fun.
Observational poem
Tastes interesting
Good, not so good
I wonder what the director bee thinks of the flavor
She's used to it
Royal jelly
York peppermint patties are good when you dissolve them in your mouth
Did they used to be smooth?
The amazing phenibut makes my skin not itch
Yay penibut !
I checked my email yesterday
Will I check it today?
Couchurfers.
Things that fill children with happiness,
Although live in boyfriends have among the highest association with risks to children, it is likely the upper third of beneficialness at live-in boyfriends are beneficial for the children to know and communicate with, cameras, audio, and computers at the dwelling could qualify if the boyfriend is at the upper third of live in boyfriends, and the live-in boyfriends that were more successful than the previous parent or the mother, and then prompt children to beneficially interact with the live in boyfriend, this would provide the child with more, and more beneficial, examples of how people live and what they do than the child would get from the mother or other-parent visits alone, so if I were a female computer programmer, and my live in boyfriend was at the upper third of absence of risk, and the boyfriend (perhaps a mathematician that consults on applied mathematics) was more successful than I was, then my daughter could learn about entire realms of activity, career, educational, fiscal, and physical activities I was unaware of, benefitting my daughter, notably at mothers with numerous sequential boyfriends or simultaneous boyfriends this could be especially apt and productive, giving the child the optimal data from annual or less frequent new live in boyfriends, for each 100 million persons the prompting software would benefit 16.6 million only children or more than 40 million non only children, noting multichild families, Amazon echo dot or Cortana child advisor could prompt child-live-in-boyfriend conversations that went deeper than pleasantries and touched on 14-40 areas that tend to cause success and the live-in boyfriend could contribute what they know and what worked for them, the CPU speaker could also prompt the live-in boyfriend to bring the child along to their daytime activities, the CPU speaker could blend the 14-40 topics with fun, happiness causing things so the child and live-in boyfriend would have a good time, prompting further software use
Longevity technology
Would an enteric coating on a regular multivitamin make it function better, the introduction of enteric coated Centrum could also be an occasion to talk about Centrum's new longevity and healthspan increasing AEDG Epithalon and 10HDA, I read half of Americans take a multivitamin so advertising things that reach them about the benefits of longevity drugs is beneficial
School buses could have psychometric test generated seating charts where half the bus was sit wherever you like (preexisting friends might want to sit together) and the other half of the bus you sat near a person the software estimates would make you happy and perhaps become a new friend, also, children living less than a mile apart who were compatible with each could be seated together, seats could be rotated three times a year, it is possible if sit anywhere is at the front of the bus this could reduce potentially deleterious back-of-the-bus groupings, there would be an absence of insistence but a screen on the back of each seat would say who sits there and have some conversation prompting questions and statements or images, dollar store LCD calculator suggests $20 to label half the seats on a bus
Longevity technology
Insurance companies build up a pool of funds at the company while getting funds monthly so the company gets both a pool of investments and cash flow
Insurance companies profit when they favor longevity drugs and technologies, and advertise longevity technologies, and they have a financial interest in funding the development of longevity technologies, noting that, and that they aim for a particular return on their investments, insurance companies could blend higher volatility longevity technology companies shares with less volatile investments while maintaining their rate of return, during 2019 AD the combination of rapamycin, senolytics, and AEDG epithalon which all have separate mechanisms, could heighten longevity 104%, if so, then insurance companies remit less funds less often, their investment pool grows and they collect money from people longer, they could also gain clients, advertising: just two days of taking any of the longevity drugs on our list (senolytics, oral or snortable antigens to mTOR receptors, other better longevity drugs), we'll send them to your door! That gets you 20% off life insurance, $700 cash up front, or 11% off a home-automobile-life insurance policy package switch to us now!
Things that make children happy
Optimally children would play with social companion robots, toys, other children, the internet, and adults more than they watch media, if media watching occurs then a CPU speaker could have a fun conversation with the child about the media heightening children's enjoyment, content could range from neutral, "what would you do if you were the main character", to educational, "they should show the people building the spaceships" an adult can configure it onscreen