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Tire coating, get your tires painted/coated with something environmentally friendly (perhaps dissolved recycled tires) and your tires might last the life of your car, this could be applied every time you get an oil change or a lubrication job, perhaps automatically, online it says traffic paint dries in 2 minutes with a heat source, 10 minutes without, cyanoacrylate adhesive solidifies in seconds but is crumbly, it could even come in colors
Respiratory infections were a leading cause of death among children in 2019, genetically engineering yeast to be just the right size to inhale as dust and that contain antibiotics, antivirals and mucolytics could treat this, it is even possible the yeast could have disease preventing antigens on the outside or inside of it and do vaccinations when inhaled as a powder or, possibly, simply eaten
There is a published study that says dendrite length and number of branch points is numerically linked to higher IQ, genes that effect these and increase them are likely to be beneficial IQ heightening genes, also there are lists of proteins that effect dendritic morphology published, with each of these proteins there is a gene that codes it, sequencing the genomes of a group of people with IQ over 180 then finding any shared trends in the genes that code for dendritic morphology amongst the IQ 180 or higher persons then, at mice and primates,replacing the dendritic morphology genes with those numerically supported amongst the 180 IQ persons, both as separate gene-proteins as well as combined in groups, is likely to find specific gene alleles that can be used at genetic engineering, germline modification, gene therapy, and drugs to beneficially heighten human intelligence, I favor increasing human intelligence voluntarily and would genetically increase the intelligence of my children, modifying their genetics so their children would be of higher intelligence
Some plasma proteins cross the blood barrier more than others, taking a sample of material from plasma then finding the 99.9th percentile of proteins that pass the blood provides a list of proteins that may be ready-made protein drugs, these can also be used as models or construction sets for completely new protein drugs, also to find proteins, possibly proteins that effect neuron morphology like dendrites that increase intelligence blenderized human brain homogenate could be injected into mice and primates and then the 99th percentile of those that pass the blood brain barrier could be new intelligence enhancing drugs, possibly permanently increasing human intelligence, these 99th percentile btain homogenate proteins that pass the blood brain barrier could also address voluntary personality adjustment and psychiatric applications
Dosing monkeys with stable isotope tracers from conception to one year of age, then using the easier to spot stable isotope versions at the 99th percentile of brain homogenate that passes the blood brain barrier screening to find brain proteins that pass the blood brain barrier is another possible technique
Any source of protein can be used at the 99th percentile or 99.9th percentile of passing the blood brain barrier screening, that suggests that plants, invertebrates, endoliths with million year lifespans, and other organismal sources could be screened this way to find ready made protein drugs as well as construction kits
There is a chance that some longevity causing protein passes the blood brain barrier, million year lifespan endoliths, 400 year quahog, 40,000 year king's holly could all be screened to find the 99th percentile of passing the blood brain barrier then screened at mice to find out if they have cognition preserving or longevity
Online it says astrocytes next to regular endothelial cytes causes them to turn into something kind of like blood brain barrier endothelia so it may be possible to tissue culture blood brain barrier membranes to do measurement screening of proteins from things like brain homogenates, from making this they could screen anything, not just fractionated organism homogenates, things like microfluidically produced combinatorial libraries of organic chemicals
Genetics of vitamins D production as wellness genes, beneficial gene therapy, while remaining white is there a genetics of the antidepressant effect of tanning beds as a form of antidepressant gene therapy
Snortable freeze dried adenovirus, or bacteria filled with adenovirus and a cytomembrane dissolver as a powder could be as cheap as yeast, retail 5¢ a gram, 100 mg dose .5¢, as an intelligence increasing longevity gene therapy drug available
I saw a thing with about 7 different kinds of parallel universes, one was spatial repeats, two were brand effects, two were bubble universes, so cheap ways to create "negative energy" is there a casimir effect way to create negative energy, if there is a casimir way what volume of casimir stuff is sufficient to produce a new universe every 24 hours, can the casimir makers be angled to produce universes with particularly benevolent characteristics
They could look at human genomes and compare them to social stress resistant (SER) mice genome difference with stress susceptible mice, it is possible that just a few genes confer resistance to social stress, if they find these at humans it could be beneficial, "control mice (CTR), stress susceptible mice (SS) and stress resilient mice (RES).","mediates depression in mice with chronic social defeat stress (CSDS)"
EEGs that cause truthfulness, playing back EEGs into the brain potentiates learning, could playing back EEGs of a person asked questions (emotionally complex or easy) who is answering truthfully cause a person to be more likely to make statements that are true, like "did you take that candy"
St johns wort is only 2.5¢ a pill, noting weight and size differences, and that sometimes nervousness occurs at too high a dose, it is possible a "change model" where .1, .05, .25 and.5 proportions, delicious candy coated, could be at a "#" pill container then people could customize their dose to get the greatest reduction of depression with the fewest side effects
Could topical liposomal opiate peptides relieve skin discomfort and itching from things like rashes or acne, this is likely a femtogram dose, even eating a few whole containers full would not cause intoxication, and the opiate peptide could have an enzymatically degradable part, a stomach degradable part that would passivate it, GSK
Could putting antibodies to bacteria and festooning these with antibiotics treat antibiotic resistant organisms, enteric pills are a possibility as vaccines, insulin, and viruses can all be delivered with enteric pills
Potentiate g coupled receptors
As a new antibiotic could there be a molecule (like, but different than ethidium bromide) that intercalates (like intercalate but not DNA) bacterial surface receptors propping them open or making them go nonfunctional that is particular only to receptor types only found on bacteria, that could weaken or terminate the bacteria, or if reception can be amplified with an intercalator, make them more susceptible to another drug (like if it were a g coupled receptors splaying or compressing the gcpr projections would make them more sensitive to a drug or be effected with completely different drugs
At humans, nontoxic intercalators of external projections on receptors, like the finger like projections of g coupled receptors could amplify or decrease receptor response, so the nontoxic intercalators could amplify the dose effectiveness (mg per dose) of other drugs and even create new shape based receptivity to completely new molecules, permitting new drugs wikipedia says its a flat thing (tribenzene) with a pivot so maybe a duobenzene or quadrobenzene with a pivot might do something, they could also put a bunch of alpha helices in a container, screen a library of a bunch of different chemicals and then sort the products on shape, anything that introduces an angle or a kink in an alpha helices could be a GCPR modifying drug, imaginatively phenylacetylene or diphenylacetylene or trip he by lac style me look kind of like ethidium, or maybe something really gentle like a benzene, maybe with a DMSO like sulfur on it in the middle of it or distal at a short few C fatty acid
I read that there are antibodies that can attach to a receptor and highly activate it, if there are antibodies that Prop open receptors as well as the glom and activate ones these could be made as antibodies from a these could activate bacterial surface receptors found only at bacteria and confuse them or terminate them (turn water or ion pump to high on, always on), the vaccine could also make bacteria extra receptive to antibacterial drugs
Wikipedia says "Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins." Would attaching clavulinic acid, or any actual antibiotic to a membrane transport moiety or peptide that only works on bacteria be much more antibiotic at much lower doses, rather weirdly this could work with antibacterials that are not antibiotics at all like Ag-(peptide)2
Hmm can you attach a "quat" antibacterial to a cheap polymer like 10W40 motor oil that rolls up into a clump, and festoon the 10W40 with moieties or peptides that only have cytotransport at bacteria, there could also be an enzymatically dividable linker between the "quat" and the 10W40ish polymer
When antibiotics are combined with electroporation it actually makes it so less stuff gets into bacteria (DNA), but perhaps there is a voltage and frequency that causes more stuff to get into bacteria, if there is then topical antibiotics and a handheld electroporator could make acne or other skin infections respond to treatment sooner
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