[NOTE 70] epigenetics of the superwell, put that in oral childhood immunizations Germline gene makes rna, then
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Sat, May 8, 11:52 PM
to me
epigenetics of the superwell, put that in oral childhood immunizations Germline gene makes rna, then rna modifies epigenome to make all humans superwell, similarly any epigenetics of heightened cognitive ability are makeable into germline enhancements
anti-SIDS technology clips to high side of crib or is 1 year flytime Mylar balloon does audio and video and compares microacoustics of heart and respiration to dataset on internet for continuous well baby screening as well as sids research (20k/yr pre 2010); the intervention machine in the crib could splash water, make white light flashes, on aliba the balloon version could be 19-20 cents each on alibaba including helium; deluxe spritz water or other drug is 69 cents. The drone version watches baby play outside the house as well as nursery, previously described soft white drones as soft contact harmless white porous polymer mesh container
The balloon version could have blue and green lasers that draw beautiful images that babies particularly like on the ceiling
THz camera version sees the baby through blankets, and internet processing of data can discern the babys respiration and heart from people like parents or siblings the baby is sleeping with
Awareness of human anti-sids rescue balloons is you can get them for a companion animals as well, baby animals get a lot of endearment. Popularizing the custom anti-sids genes companion animals can be given popularizes giving humans new anti-sids genes
Layered paint on thz built up waveguides may be possible, especially if a waveguide maker alternates build up spray (or 3d print) with fine edged laser channel etching when making waveguides
is a phone antenna next to a waveguidebetter than a plurality of antennas?: it is at a sattellite dish, so could benefit phones with space based internet (starlink) 2d brain slice looking data pick-up (antenna(s) and waveguides like (=|=) or (::|::) could be a new better space phone antenna
Steadicam replaced with image sensor immersed in optically transparent gel which dampens vibrations more than just affixing or bolting an image sensor can be cuvette flled with jello thrifty:driverless vehicles have sensors like video camera or lidar; steadicam image stabilization would be complex but putting a video chip in a cuvette full of magnetic damped jello could be much cheaper; with use at vehicles this could spread to nonvehicle sensor uses like robots, milling,CNC and jello eyes on drones and power tools and agricultural vehicles; At these applications the actual image chip vibration is dampened and information data processing deblurring complements the camera physically wiggling less
Sexy garland video camera is image sensors and faceted fiber optics and photovoltaic polymer in a weave. It makes a video data file of of itself at 720 degree sphere that also has software processing to make planar videos and 3D videos. garlandness The garlandness has surface photovoltaics and ambient passive RF energy harvesters along its length, leaving a video garland around the bedroom makes automatically recording sex videos at the dwelling effortless and multi camera angle effective, software automatically generates cinematography enhanced amateur sex videos and raw footage and sends them to you (people)
most heritable IT pattern white ness could be 90% heritable or engineerable to be, that way certain kinds of goodness heritability Are carried with just 1 copy number at 1 gene (c1c) while simultaneously having multicopy number in multiple locations (c9c) c1c plus c9c simultaneous, effect causes any white partner to have white children, that is human physical progeny with white IT pattern way of living, way of benefitting others and hosting the genetics and phenotype of the 99.9th percentile of the light triad psychology test (metric), new synthetic genes and alleles that physically cause the 99.9th percentile light triad metric and phenotype, the new genes and alleles are c1c and c9c forms and are germline engineered into the earths entire population utilizing globe spanning bacteria and fungi that do gene therapy on all their habitat which is all the organisms. Notably this engineers all mammals to have high light triad neurochemistry which confers benefits on them as well.
The previously described garland video camera also can automatically record a family room or also a children's room to make an enjoyable to watch 180-360 second video that the software makers deem the most enjoyable to watch and share.
Three data pool longevity genetics, i may have written about this before in a paper notebook, a data diff or "sequal" query can do much more than just finding positive antiaging chemicals and genes it can find things where if they are absent the organism lives longer; again these can be combined into the same query: at tortoise and human shared genes which simultaneous upregulatins and downregulations have the greatest magnitude of effect; version one answer is 50th percentile magnitude of effect and above, version two answer is the entire set.
Similarly using three species simultaneously provides longevity genetic technology advantages: if high at tortoise and human then engineer to be high at mice, including genes that make synthetic new genes and alleles that are more active than human or tortoise versions of a protein, that tests an "even moreso" version of a prolongevity gene at the mouse species beaver(35) mouse human groups could be compared
i read that genes and phenotypes associated with hibernation are associated with greater longevity, differing rates of gene accumulation and change could generate hibernation accelerated regions (HbAR)just the same way human accelerated regions (HAR) are found at Homo genus. finding HbARs then testing their effect on longevity when engineered into mice is a longevity technology that can then be tested at humans with age-batched groups of human volunteers
Which HbAR branches are most longevizing
hibernation acceleration regions "Direction of travel" extended to become new human longevity genes from making new synthetic HbAR-like genes and testing them on marmosets first then age batched groups of human volunteers; testing both the gene therapy and the HbAR genes'protein and peptide and small molecule and mRNA output for longevization effects
Diif hibernators same species strain lifespan longest lived version teaches longevity mechanism source, attaches it to just a few genes
I think that childhood injections should be replaced with oral or snortable injection alternatives as frequently as possible, where there is injection it should be replaced with the needleless air pressure injection
improving pop cans: alumina oxide layer could be anticatlytic form of catalytic alumInum oxide crystal, preserving flavor
side thickness or bulge thickness at fingernail area that opens can could be wider or bigger volumetrically; with new aluminas at the can coating that means the can itself can be made out of cheaper than aluminum alloy, i havent looked it up but manganese element and iron element replacing 50% of the aluminium in pop cans would make cans twice as cheap to make
Qr codes only visible to computer cameras could make diffraction grating shimmer qr codes that, as the shimmer is invisible to visible range look completely visually homogenous and blank to a human viewer but are full of computer data. one use of this is that every recycled container can be tracked, and, at reedemable cans makes it so even a fragme7nt of a completly mashed can can be swapped for money
ACtual physical sims-like diagnostic gem that floats above their head is a drone:
Undulating paper airplane wings could keep aircraft such as drones flying full time. peristaltic surface wing flies itself, something like peristaltic motion, also an airscrew in a sound insulative tube, or even a bundle of tubes with side tubes controlling yaw pitch and roll are i think possible. it might look like laminated panpipes, with a small amount of them, or their recorder apertures sideways, lots of computer dynamic balancing makes a new to me kind of aircraft, notably a .5-11 gram noiseless (peristaltic wing)drone that people could have noiseless SIMS (sims 2021 computer game)diagnostic and touchless data transmission hub. power could come from ambient rf or beamed power i perceive that white, blue, and green are beneficial colors to make the floating gem
Way to sort sperm: the idea is that the sperm body parts like acrosome and tail are chemically slightly different from each other with genetics, becaue these sperm parts are produced after meiosis they may have external chemistry differences between differing sperm from the same male; this makes sorting sperm on some new correlates to the actual genes in each separate sperm possible where previously studied data is aguide, to sort say 100 million sperm on their most optimal phenotypic-correlates-genotype chemistry ir spectroscopy could be used; this way 99th percentile ranking of sperm is microfluidically concentrateable to e used at the vagina as a 1 million viable, with correlations to better genetics sperm Insert. it is even possible a genetic improvement and life improvement sex lubricant cpuld have antibodies to nonoptimal sperm-after-meiosis sperm, leaving the top most 1% of sperm alive to fertlize the egg. noting the most affordable antibodies are $465/gram and only a few micrograms are utilized, making genetic improvement lubricant identical to median sex lubricants in cost
I Think coolsculpt cryozone fat disintegration technology might be usable directly on the surface of the heart, it is uknown if this fat is deleterious but if it is laproscopic coolsculpt could address it. it could even have warming lasers on the coolsculpt zones to heighten resolution; a strategy that could be used anywhere in the body
Coronary arteries unlike leg arteries get gunked up; why? comparative mammal ungunkedness and cardiac development genes could be tested at nonhuman primates to engineer better coronary arteries
Bremelanotide is a sex drug that effects mcr4 and mcr3 receptors, a drug with sex effects would be a new kind of tail nestling peptide that nudges the actual receptor protein to make it think it was fully occupied, variations of this new peptide could be linked to a blood brain barrier passing moiety or peptide.
Improving mass spectrometry improves mRNA profiling (gene expression profiling), solitons are published as improving spectroscopy; could using groups of quantum entangled photons to make the solitons out of improve rsolution or rapidity? also there are different kinds of solitons, could Dissipative solitons with their published 100 times greater durability improve spectroscopy further?
SOftware measures IT pattern, Wikipedia phrase: nonparametric statistics make fewer assumptions which provides absence of preloaded assumptions about what IT pattern things occur
science and math: they could search histogram data for soliton forms of histogram undulation, suggesting some interesting relation at the phenomena being measured
ARtificial widom, "example, the naive Bayes classifier will make the correct MAP decision rule classification so long as the correct class is more probable than any other class. This is true regardless of whether the probability estimate is slightly, or even grossly inaccurate. In this manner, the overall classifier can be robust enough to ignore serious deficiencies in its underlying naive probability model." as artificial wisdom, such as at search engines and living-advice software, "Most bayesian probable personal motivator" find fewest things that have to go right for a particular instance of bayesian psychology (a person) based on database of what works, to realize a goal or seek a mindpace that generates happier mutually beneficial goals
THe statistics of the least likely thing to occur, that is observable could be like 1-bayes
finding a plrality of least likely things to occur, as outlined by math at a large dataset (million proteins or trillion optical measurements) finds new scientific discoverables when they do occur as these improbable things are mathematically universe age @sampling rate unlikely yet are measured as occuring
JY said looking at a persons future was like viewing a fisheye lens image with the far future eentsy at the perimeter cobalt blue lenses that turn fisheye to map-projection like hypersized perimeter could make viewing far future (perimeter) higher resolution and what jycalled "expensive". at IT pattern resonance craft optical computing lab bench on a chip could have cobalt blue optical elements or also cobalt blue laser, with same spectral lines as deep cobalt blue glass; they could also test lapis lazuli spectral lines for effect
NOnparametric statistics heart ekg; photonics of volumetric heart beating map are used as nonparametric statistics to find new lifesaving relations and kernal groups(?) of ekg and photonic heart profile; new drugs that cause this make it so there are fewer heart attacks, they are more survivable, and do less harm
Photoactive sarm or steroid builds up particular heart microlocations to be like preclude heart attack ekg/photonics profile
Photoactive NGF on vagus nerve and spine could be systemically administered and then possibly invreased in nerve conduction velocity and, beneficially at making vagus-connected organs at mice and marmosets work better and longer; extrnal to body cofocal holographic computer-steered light source lights up just the vagus
logevity technology: With awareness of nonparametric statistics a yeast lifespan protocol could find new non-genetic bases of heightened longevity: 1 billion clonal yeast at chip dish, find outlier longest and shortest lived, reculture to fill billion dish chip with descendants of longevity outliers, measure everything, find nomparametric data patterns of nongenetic longevity sources, make those longevity sources into drugs
Growth factors like NGF, BDNF, others might dwell longer at receptors if deuterium replaces hydrogen,
mRNA profile of sleep (compared with awake), as a source of regenerative proteins and RNA drugs that do what sleep does; possibly adminsterable while awake, also epigenetics of most restorative sleep, this could be a wellness drug and a nootropic as people think better when well rested
there are video lab mammal habitats now that record lab mammal behavior throughout the experiment that are interpreted by software, enhance this with continuous or periodic CT scan of the mammal habitat as well as continuous MRI and spectroscopy of the mammal at the lab container; developing longevity technologies and therapies, treatments, perhaps simultaneous could be characterized as to their producing youthful phenotype, at many defined, as well as pre-definition nonparametric statistical methods. clonal marmosets could be raised in the multiscanner environment
maintaining peak most amplitudes of whole genome mRNA expression found in human 8 year olds throughout living could be a longevity wellness technology; keeping the vertices uncrumbled metaphor
longevity technology: wiipedia says, "Gene set enrichment analysis (GSEA) (also functional enrichment analysis) is a method to identify classes of genes or proteins that are over-represented in a large set of genes or proteins, and may have an association with disease phenotypes. " use GSEA on long lived organisms with longevity phenotype compare White footed mouse with regular mouse; 400 year lifespan tortoise/human to find new longevity gene Classed and protein system overlaps
Bowhead whale/human is another GSEA pair
GSEA of a young and old marmoset, then computer word: diff on GSEA of a young and supercentenarian humans finds new gene classes that effect longevity, those linked protein function classes find completely new longevity cytoprocesses and receptor networks to use as a basis for new longevity drugs as well as gene therapies for humans that change proteins to their intensified "even moreso" amino acid sequence forms
Manufacturing line station swap-betweens and statistical measure of being most like 95th percentile awesomenes of a particular manufactured object like a computer chip or a car; interferometry and hyperspectral image sensor spectroscopy, Airjet percussed audio ping function
Replace or remix 7th percentile tools/manufacturing stations/robots
For snortable drugs what amount of drug-velovitizing effercescence and surfactancy is without perceptible irritation, alternatively does putting a deliciously flavored topical anesthetic in the snortable drug make higher dosages and velocities possible; electoimpelled iontophoretic mica-like flake could drive extra rapid and sustained delivery from a snort
Lipid fraction and water fraction of plasma; dissolved RNA drugs could reach particular tiss
ues (brain hydrophobic) better
mRNA drugs like a library of epigenetic drugs from plants; radioactive; at a dna squence most like the mRNA to be made
Teoligo matches to dna location blows it apart, some stochastic thing fills it in; at million or billion dish media plate variously plant cells, yeast or bacteria are the things the radioactive oligo nudges; use spectroscopy at million dish plate to find out which cultures are making new mRNA that is equivalent to a human designed epigenetic mRNA drug, Like a longevity drug, then culture that organism and gather the drug; just genetic engineering is better, but as a non-genetically engineered mRNA drug catalog these could be valued
(that was note 70)
(different note)
[NOTE 69] a new way to talk about the weather That has cute talk like bask bask
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Sat, May 1, 10:22 PM
to me
a new way to talk about the weather That has cute talk like bask bask
Raining at night everythings right;rain in the day please go away
Say 'sunny day' instead of hello when the sun shines "Sunny day (name)" wfip
"Its bring your girlfriend weather"
"tell the tesla to tour the sunbreaks"
we got swimmers high (so rained on you cease feeling the rain)
looks like a sidewalk cleaner this afternoon
Its somebody's birthday
The air is chilled fruit
A month of dawn (march)
cuddly
Quick! drive under a tree
Note positive reinforcement phrase loading makes people like the actual weather better
longevity technology: There is a slight chance lsd and other psychedelics makes mice and humans live longer from enhancing social skills permanently, they could measure this, if so new hyperdurable psychedelic niceness drugs that longevize from a single dose are likely possible
(new note)
[NOTE 68] blocking adenosine receptors is what i read makes caffeine a functioning stimulant; something in the
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Thu, Apr 29, 1:36 AM
to me
blocking adenosine receptors is what i read makes caffeine a functioning stimulant; something in the body then metabolizes the caffeine; it could be that as part of ATP adenosine has wide or specific uptake at some kind of molecular transport channel, drugs that increase the uptake of adenosine at these cells, possibly abundant cognitively less contributing glial cells, would then be completely new to me stimulant drugs possibly likely to be as safe or even less risky than caffeine, which during 2021AD was the world's most popular drug non-neural cells. The specific localization to brain of the Adenosine Uptake (AU) Drugs (AUD) controls what the AUD feels like, some brain localization pattern of AU is likely more stimulating and pleasant than caffeine and absent what are called jitters.
Finding an already available, instant herbal AU stimulant drug may be possible by screening molecular libraries already known at plants for AU activity at trace amounts of chemical then engineering or breeding the plants to make a lot more of that AUD to make a better replacement drug for tea and coffee. The screened AUD plants will have their own flavor, and that flavor can be improved as part of the breeding or engineering development process, and the AUD plant can be optimized for automated harvesting which makes AUD beverages even cheaper than coffee and tea.
b
As a sex technology: does AU inhibition cause other non-cns
Easy test dissolve caffeine in DMSO and apply to human penis as well as human clitoris then see if they have any change in sensitivity like greater beneficial clitoral sensitivity or greater beneficial penile sensitivity then an internal vaginal canal as well as internal anal canal DMSO-Caffeine lubricant could be tested for benefit
showing support for sex work including cam girls and guys are technologies that could make them more money, licking viewers cum (ejaculate) off of a $20 bill and getting a personal 28 second video of the camgirl sexworker opening the envelope, rubbing the still damp or dried $20 on her pussy then bringing it to her mouth to lick the shining juices (actually lube at her pussy) off, and says, 'thank you George', if the $20s arrive in the mail from chatgirl clients, and it takes 2 minutes to make each 28 second video she is earning $600/hr or $1.2 million a year from licking cum off $20s and sending back videos of it
People that get physical things sent to them that they get from camgirls could also get, without requesting it, a prestamped envelope to send a $20 to the camgirl. There are also variations where the client only has to use their credit card to order a $20 smeared with vaginal juices sent to them for $39.99, 100% markup on the $20, and the camgirl generates revenue at double or higher velocity, $2400/hr
I saw a site where cam girls are given tokens by admiring viewers, a new kind of token could genuinely benefit the girls: Love The Girl (LTG) tokens are actual money, you throw a dime they get an actual dime, you throw a quarter they get an actual quarter, and camgirl clients can get them $18 LTG for USD $20, so the camgirl company makes 20% off of near zero effort; even if camgirls already earn much more for their web providers, advertising Love The Girl (LTG) tokens could be a big site draw and attract sexual 'white knights' and Nice Guys(tm) to camgirls, white knight and Nice Guy are slightly complex 2020AD informal American English phrases
IT pattern resonance technology: JY said 'if you have a million dollars you do not have to go' one possible interpretation is that this refers to pattern recruitment, the thing is that during 2021 AD I was not aware of any children that are USD Millionaires with the money titled to their name
millionare children with title to the money exist, find millionaire children with the assets titled to them, then have software measure them to find out if they get pattern recruitment, if they omit pattern recruitment, then that is what JY may have meant
Changing civil law and the tax code to favor people titling or retitling assets like family houses and cars to children causes children to be assets titled to their name millionaires, in Japan a million Yen is near $10000 making Japanese children millionaires with almost any asset retitling, this could beneficially cause an absence of recruitment at Japanese children
They could make a new publically used and arbitraged new cryptocurrency (etherium and bitcoin are 2021 AD cryptocurrencies) where a million units is 25 cents at toy dispensing machines that children could use to become million currency unit holders using money they physically held that was given to them, it is beneficial if the childrens cryptocurrency has IT pattern letters like letters at gowcoin giorwii goodcoin, Gcoin, one advantage of a children's cryptocurrency is that it has global span and reach, meaningfully adults would also use Gcoin to do actual things, making the children millionaires in real money
Nonhuman primate 1.1 million juice box millionaires software characterized as to pattern resonance effects
JY may have meant something about people, if any, that become previously alive with Jy saying 'if you have a million dollars you don't have to go,' that suggests banks and credit unions prepare their statements with columns showing how the person has a greater than million currency units at a different country's money. right there on the monthly financial statement it says the person with the account is a millionaire.
(new note)
[NOTE 67] air injectable goo that photocatalyzes to semirigid biocompatible material for faces and vaginas: th
Inbox
Thu, Apr 29, 1:37 AM
to me
air injectable goo that photocatalyzes to semirigid biocompatible material for faces and vaginas: think of airjecting (air injecting) goo like hyalonuric acid or collagen to the vagina's canal had a ( ) two artificial tendon connector out the canal up the sides of the labia and curving into the clitoral hood; every thrust at the vaginal canal (penile or fingers or sex toy) would squeeze and move the clitore al hood and clioris enhancing female sexual pleasure; as an airjected then light sculpted polymer it could be affordably installed by an aesthetician, a robot or a doctor in less than 20 minutes and would cause much more pleasure than a clitoral hood piercing; photoectivated epoxies exist now just make a photoactivatable one; this millimeter or less photocatalyzable polymer strand could alsobeused in cosmetic surgery on faces and shaping and lifting breasts
Clitoral hood piercing has supermagnets in it that respond to supermagnets in nub on cock ring to move clitoral hood; electromagnet on vibrating cock ring possible
prune fingers are apparently nerve detection of water enhanced; if that enhanced nerve mediated osmosis activity is also present at regular non-palm skin then an absorbable nerve drug
Vaginally absorbed paleness bremelanotide sex enhancing lubricant and liquefying vaginal inserts are possible; anybody can use it but i'm imagining a consort inserting an insert or masturbating with the bremolanitide lubricant on a daddy's instructions an hour or two before he gets home so she will be ready for him
ii recently got a vibrating buttplug (VB), my first sex toy Ever from Amazon.com, review gradually underway
VB could have an accelerometers in it, as well as a CPU that senses body motion,rhythms and room sounds from both partners,the vibration, and even sound from the VB (It could have a speaker) could say things like 'Faster' Or 'slower' or 'vigor fuck', 'Gentle fuck', on sensing, the CPU program would make the suggestions that cause the most intense orgasms and most multiple orgasms at the insertive and receptive partner
Soft foam trumpet mouth penis sheath scientifically measured as making multiple sequential rounds of anal sex nonabrading to the anus, so the receptive partner seeks out more sex actions per day, this could be especially attractive to people with sex daddies, because when the sex daddy tells the consort to say 'please fuck me daddy, please if you please' and her or his sex daddy says, 'is your ass bleeding? you can't fuck if your ass is bleeding.' then the consort says to her Sex daddy, 'Kind Daddy fucks my ass so hard with a soft Tee my asshole is clean and ready for you Daddy' A Soft Tee is a trumpet shaped penis sleeve that also happens to look like a golf tee, the inverted mushroom head base is a very soft anally nonabrading material like a headphone pad, the top half of a penis extends nude beyond the base half of the Soft Tee like a fingerless glove, the base of a Soft Tee could have autolubricating when wet, glide strip polymer all over the soft puffy base to reduce anal abrasion during anal sex as well
(like a hollow stem valve a person puts their penis into)
i like sex with Aryan people decal is better than card suit decal, white outline circle with cumlike white droplets right inside and outside the circle, cumlike means sperm with semen like; the graphic suggests that her vaginal canal is for Aryan sperm and semen
different a nal lubes feel different, combine option of greatest preferred feeling to receptive partner; microbeads could make it feel beyond saliva in the saliva ddirection, thin as saliva but thinner based lubes, msg lubes (topical neuron activator, nonirritating) opposite in the numbing direction are brief activity anesthetics that last long enough to soak into the anus (or throat-no gagging) but have time to transdermally soak into the mucous membranes of the throat and anus; coolness could do sensitization like clitoris so stray lube actually feels better
gaba up, glutamate down, ion channels down is a brief acting neurotransmitter blend that could anesthetize Peptides in one stripe of the lube's aquafresh tube and proteolytic enzymes in another part, or at a nonpolar solvent like silicone based lube rapid fizz to solution when it meets wet anal or throat mucous microbeads, there are already supermild feeling microfizz sublingual tablets in 2021
A lube called :Throat Training-Depth and Comfort could possibly work
Review:unintended anal training, the vibrating buttplug feels about twice as good two days of use later, with about 5 hours of use each day and unexpectedly became much more pleasurable to use like a dildo, so i'm looking forward to the glass dildo i ordered from amazon
mixed, non peanut nut concentrates to increase male (potentially female) sex potency: a previous girlfriend suggested i eat nuts to improve her sex life and mine, now, decades later i notice when i eat just 3-4 ounces of nuts i masturbate more and enjoy it more the next day; they could centrifuge 111 mass fractions of mixed non-peanut nuts and test them on mice and humans to see which chemicals in the nuts cause the effect, then put 11 times as much of that chemical in a pill to make a new to me sextropic drug that might even be an aphrodisiac
(new note)
Sex toy: cock ring has attached multinch taller than clitoris is above vaginal canal hoberman sphere of vulval cleft and clitoral contact shape (tubeish with side flaps) or clitorally stimulating but racecar look; just like 1-10 ¢ disposable vibrating cockrings on aliba the vehicular looking hoberman shere tensioned to puff up to fill the gap between pubis areas at person on top sex: the hoberman tubeoids expansion works on struts and the soft rubber coated struts have acoustically resonating microbeads on them; the hoberman tube also comes coated (perhaps sputtered/cvd with a autolubricating deliquescent polymer wetter and wettable like glide strips; the purpose of the hobermann vibrating cock ring is to produce pleasurable direct clitoral stimulation during woman with man horizontal face to face sex
The hobermann cockring hobermann part would always be able to compress down so to-the-hilt of the penis at maximum depth remained possible
Variations include inductive antenna power from antenna in room, beat frequencies of piezoelectric vibrators could be optimized for pleasure at the resonant beads, and sexy styling like fMRI squiggle that appeals to 9 out of ten people;
Peacocks fan out a tail as part of mating a possible name is peacock tail, another is O-doily, cocktail vibrator, love cape, Hobermann, O-ball cockring
Wand massger together with egg vibrator cofocalizes vibrations on front anterior of vagina and clitoris through front of body tissue to middle of vaginal canal for even greater pleasure; software detects if intravaginal orgasm from egg comes first or if exterior of vagina clitoral wand orgasm comes first, then heightens vibration intensity at the other areas vibrator intensifying or possibly extending the orgasm with heightened stimulation of nonsensitized tissue; on the internet and in print some women mention using an anal insertion vibrator along with a vaginal insertion vibrator; along with external wand it is then possible, i think, to cascade three stimulation vibrator orgasms; how does the software know if the person has vaginal, clitoral, and anal orgasms specifically: neural network or other math correlate of what focus or locus of orgasm might be able to do it, even easier might be neural network or math correlations based on sex noise style as each of the three seem to go with very different sounds, or just laser interferometry or ultrasound of vagina ($2.5-5 aliba) and yxz accelerometer describe what kind of contractions where, pulsing clitoris are at CPU vibrators or IoT vibrators and phone or smart speaker technology
With the software knowing which orgasm form and when at individual users, it could overlap stimulation intensities and durations to produce the timing of multiple simultaneous area orgasms
gentle Torquing motion of shaft base after glans orgasm at fleshlight prodides contunuing pleasure at penis
Longevity technoloft, at humans there might be thousands of ruplicates of the genes that make ribosomes, possibly with dozens of different promoters and distancces from start codons, at bowhead whales find the ribosome genes that are associated with the ribosomes above median and above 90th percentile of product fidelity and rapidity of production; modify the epigenetics of those superior ribosomes to be more frequnently produced (demethylate and acteylate the best ribosomes genetics) then see if at mice the mice are weller and longer lived. Amplitude heightening of ribosome gene epigenetics that are most like bowhead whales' best ribosomes and huuman supercentenarians best ribosomes could be particularly beneficial; peptide ribosome epigenetic drug immediately possible
Zebrafish and mouse longevity of tissue measure; raise clonal zebrafish as well as mice with one clone making GFP, when a well 99th percetile of longevity mouse or zebrafish is well at an advanced age, flash freeze the entire mouse or zebrafish, then take tissue samples to inject into a plurality of clonal teen mice; see if each of the 100 GFP tissue transplant types tested can live out another two or three mouse lifespans, if not, what is the limiting factor and how can that be addressed(glycation or mitochondria number)
Recreational drug beverage as well as oral buccal vaccine combined technology
vasodilator
saliva enzyme placeholder blockers
mucolytic enzyme/peptide
inkjet printed iontophoretic mini assemblies; nonmetallic organic radical batteries exist and perhaps an edible one is possible; these mini assemblies coat cheeks, tongue, and throat and drive recreational drug RNA or peptide or LSD into the circulation through the vasodilated tissues
RNAlater or better could be used as a preservative
Wand vibrator and vaginally internal egg vibrator can also cofocalize and overlap with especially pleasurable beat frequencies from piezoelectric elements
Injectable goop, fuses, ladder logic, nonturing automata, simplest possible nonfeedback regular pulse emitter could be highly regular tree from seed and generation; pulsatile delivery of drugs, from wire computing (and/or) previously described rc circuit does beat frequency to make computing Logic NOT;
that all wire no semiconductor logic could be used to build automata, like nonharvard, nonturing cellular automata at ic feature sizes; velocity of automata is beat frequency NOT;
Do highly deuterated RNA drugs and protein drugs preseve better, they might
They have likely already done neural network: image dither,
Woman or girl sexual gentital with woman or girl: tribbing; very flat hoberman doily/gappy lace with vibration and resonant plrasure bead stimulation; like a pleasure enhancement fabric scarf the people put between their legs; big gappy areas at hoberman doily scarf ensure actual genital-genital contact; vibrator power from inductive electricity antenna in room or batteries; hoberman doily tribbing fabric has glide strip polymer coating (or deliquescent polymer coating (previously described are PCA (like NaPCA) polymers or also deliquescent propionic polymers; entire tribbing fabric is machine washable; disposable version is comparable to 1-10¢ vibrating cockring, but with 4 times battery power and piezo elements vibrating resonant beads on hoberman struts; 7-40 ¢ alibaba antenna version
Wet wipes could be probiotic and also include antimicrobial (antibacterial, antifungal, antivrus) peptides that are harmless to the probiotic; the probiotic could make a plurality of beauty and healing peptides; probiotic antimicrobial and healing peptide toilet paper is also possible and could be beneficial, notably to women with getting a probiotic every time they pee
Toilet paper could have value as a depot for better than well antigen presentation, such as longevizing immunizations as it is continually reapplied along 2-4 weeks; flu vaccine and pneumonia vaccine toilet paper could also, noting 2020 effects reduce cardiovascular disease; advantages of toilet paper longevity vaccines are grocery store convenience without a medical office visit; toilet paper could also a beneficial vaccine format at the developing world,
Anti-allergy, anti-asthma, anti atopic dermatitis toilet paper/wet wipes would have phosphatidyl serine (PS) conjugated to allergens or also as liposomes around allergens which is published as reducing allergies; anti-allergic TP could be used all year
A breed of cat that is immune to toxoplasmosis gondii could reduce the toxoplasmosis mental illness effect at people with cats; out of each 10,000 shelter cats it is plausible that 9-11 cats have some natural immunity to toxoplasmosis and these can be bred together
PS liposomal sperm extract
Epigentic even moreso of genes presence or absence at immunity and partial immunity; epigenetic drug functions like europeans immune to HIV as they are abdent having a gene hiv uses for replication; hypermethylating that gene as well as hypermethylating its promoter could be an epigenetic drug routinely given to any person at 1%/year risk of getting HIV, during 20th century that would have been developing world sex workers, some homosexual males, partners of HIV positive persons; the peptide epigenetic drug that blocks HIV replication by functioning like HIV immune europeans, notably Scandinavians is beneficial to place at the germline genome of all homosapiens, that is people that is humans.
Another anti-HIV technology is the 30-60 day iontophoretic condom, pleasure sheath, fleshlight, egg vibrator iontophoresising 30-60 mg of antiHIV (like published prophylactic dose) protease inhibitors at the genitals that then diffuse out through the body preventing HIV infection; this gives the ability to give a sexually active child a vibrator present (egg vibrator, fleshlight) that blocks HIV transmission during their entire childhood; the really cheap HIV preventing gift to children would be sexual lubricant with iontophoretic Multiday release of protease inhibitor at glitter and published prophylactic doses of protease inhibitors
It seems kid of unlikely but defiirentiating factors that makes stem cells could be placed at the bulk circulatory system and have CPP to atherosclerotic things like foam cells; turning the atheosclerotic plaques to stem cells might dissolve them (earlier treatment is better) and the products, circulating stem cells are likely to be harmless or good for people;
Remove discomfort during human childbirth with CPP-anesthetic peptides that concentrate at pelvic ganglion prior to birth process; CPP-receptor Tail nestling peptides and opiate peptides are a couple ways to do it
I think they will make an effective vaccine for herpes, which includes genital herpes
Extra-pink vaginal/anal rinse; UV
(new note)
[NOTE 63] Importing and exporting a legal form of LSD between countries
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Thu, Apr 29, 1:42 AM
to me
Importing and exporting a legal form of LSD between countries
Penylethylamine is a legal stimulant that differs from a 2020 citation eligible stimulant by one methyl group; that suggests that a chemical very similar to the hallucinogen LSD can be legally produced and exported and imported in hundreds of kilograms to metric ton quantities
I asked about 20 chemists on fiverr.com to design the LSD variant, and with about 4 hours effort found 1.5 overseas chemists willing to design the binary LSD synthesis for $20-40.
i also thought of an illustrative way but an actual chemists work would be better
https://synarchive.com/protecting-group/Aldehyde_Ketone_Ethylene_glycol_acetal suggests 4 hour to turn back to =O with HCL,
Url ph of beverages in the united states; many unconcentrated fruit juices at pH3-4 ethyoxylated ring turns back to =O at pH 3.5, duration and temperature of reaction unknown;immediate? minutes? Overnight? 5 minuntes in a microwave?
T
As a possible approach replacing the oxygen
Legal LSD form has sulfur or selenium instead of =O at oxygen atom, this could also be cyclized with ethylene glycol (image) to produce export/import LSD without ever making actual LSD at the country of manufaccture
=Se or =S LSD could be a legal hallucinogen as is
Translate to chinese, russian arabic
Youtube video, slideshare and erotic video site compilation of compilations with onscreen slides between scenes
Frozen fruit juice; pan evaporation of frozen fruit juice concentrate to lower pH
Freeze conentration of bottled lime juice
Update:
So I actually got a chemist from fiverr.com to come up with new legal LSD variants and LSD syntheses. She came up with: The image notes that appear at the top of this page., she uses a single cyclohexane ring glyph <=> to mean the entire lysergic acid molecule on her drawings though.
(new note)
Oral and nasal flora at humans coulf be genetically engineered to make antibacterial peptides, and, if they exist antiviral peptides, this could prvent much of the common cold and earaches especially at children
Reacreational drug enhancement: some brain systems refill with neuotransmitters and possibly atp faster than others
Most mitochondria dopamine, GABA, LSD neurons, TAAR, these neuron tyes as well as physical brain localizations could be rapid recovery pleasure centers; women who havve 20 orgasms or more an hour may be making utilization of rapid recovery pleasure nerves and neurons; at nonhuman primates map which areas of the brain still have original amount of responsiveness PQQ CPP pleasureneurons and nerves, NMN cpp pleasure neurons and nerves; result: recreational pleasure drugs that omit wearing people out and are absent dysfunctional overhang feeling; also could be applied to nootropics that localize at most rapid recharge AMPA receptors, nicotinic AChe receptors, phenylpiracetam receptors; most rapid recharge BDNF and klotho receptors
Noting 2021 popularity of cannabis, localization to most rapidly capacity regenerating cannabinoid receptors could be new kind of sustainable cannabinoid high
Fastest regererating neuron capacity nerves might be ADD/ADHD therapy or better than well hyperfocus drug with sustained nonexhausting action, beneficial for schoolwork and as suvcesstropic; CPP-modafinil to highest spontaneous recovery neurons
Protein recreational drug or therepeutic drug where the more ATPs the protein gets the stronger the drug action from protein shape change; branched dendrimer protein drugs with 3-powers of 2 branches that attach ATP to become active drug; nonprotein drugs are also possible, c300 fullerenes that change charge of tethered few-amu drugs at their surface with ATP, GTP, UTP conentration that is cytolocal guide to any particular nerve or neuron's regenerate and recharge function rate
What if the upper 1/3 of stem cells could be induced to divide two or three times; proliferation of just the ATP//GTP/UTP superior level stem cells as a rejuvenation technology, one example could be heart stem cells and vaculature stem cells; CNS stem cells could also benefit; production of stem cells at tissue culture epigenetic ATP/GTP/UTP superiority from deuterated triphosphate chemicals at media being turned into ATP/GTP/UTP and be detectable using flow cytometry with spectroscopy to find the 99.9th percentile triphosphate advantaged stem cells as basis for higher value bulk stem cell product and new triphosphate advantaged stem cell lines;
Different than mutation is, at bulk screening of tissue culture, partial stochastization of epigenetics; using flow cytometry or billion-well ic technology tissue culture optimizing epigenetics in a manner similar to selecting beneficial mutants is possible; this is another way to make superior stem cells as well as screen billions of epigenetic variations on human tissue cultures, with the ability to install the most beneficial better than well epigenetics into actual living people's bodies
I read enzyme by-products of emega 3 fatty acids are good for people, enzymatic byproducts of phosphatidyl serine could be good for people
add therapy
(new note)
[NOTE 61] A variety of deliquescent GRAS chemicals could be screened for use in sex lubricants, contact lenses
Inbox
Thu, Jan 21, 6:53 PM
to me
A variety of deliquescent GRAS chemicals could be screened for use in sex lubricants, contact lenses, and bioimplants besides NaPCA, NaPCA polymers, sodium proprionate is deliquescent perhaps a propionate polymer with lots fewer Na or K or Rb per proprionate group is possible, these could also be screened and developed as new skin hydrators for use at beauty topical moisturizers as well. The internet says some mushrooms don't just decay they are deliquescent, suggesting they pull water out of the air, those fungal deliquescent chemicals which might be polymers could be made synthetically, or if genetically engineered into yeast could be 2-10$/kg based on alibaba chemicals. I published a video at youtube to genetically engineer edible, delicious slime molds that travel to and aggregate to places where they are signalled to, and as a new call, chewed tree leaves plus human saliva expectorated on the ground at full strength to1/300 th dilution, such that expectorating 3.4 grams of chewed tree leaves and saliva, or just 34 grams of saliva in a liter of water can be poured on the ground in various linear widths, lengths, as such as well as simple multiple mini-pools, causes slime mold nearby to travel to and aggregate visibly above ground for easy enjoyable eating by the human being; i think these beneficial slime molds would benefit from producing an optically transparent or white version of the deliquescent chemicals in "ink-cap" fungi, PCA amino acid or deliquescent PCA polymer, the range of slime molds that can pull water out of the air could extend through the desert, and make it so they are thriving and motile for all seasons. An antifreeze peptide or protein additionally could permit movement (to benefit humans) and growth during cold seasons as well.
Longevity drug possibility, both ants and termites grow fungi, they could test those fungi for longevity effects on mice, noting that reishi and lions mane are longevizing, some termite queens live half a century
a data storage medium fluorine containing alkanes, silanes, and germanes could be functional; CF4 has an environmental life of 50,000 years as an atmospheric gas
Peltier photovoltaic, or alphavoltaic or betavoltaic power source MEMs dewar could keep things cool and well preserved for a plurality of milennia, such as laser diode read GeF4 or Ge(n)F(2n) polymer dot data storage, at 100 millennia data life, arrays of GeF or SiF polymer dots would be arranged photo lithographically 2020 300 mm IC wafer, about 43 trillions of 5 nM fluoromer dots per wafer, 11 layers of dots and readers is 470 trillion bits of data; if fluorimer comes in 8 variably branched spectroscopically distinguishable types then that is 256 times more data density, or about 100 petabits of multimilleaneal data storage; if you think of a waffle on ball bearing sandwich, and have each square of the waffle have a photo sensor Laser diode combination that can do phased array reading of the entire fluromer dataset per waffle square then: 1000 squares of waffles, any one of which can photo stimulate (spectroscopy) and read (photo sensor/camera array) the entirity of the fluoromer on wafer data repository, based on the success of illumination at spectroscopy from 90-.1 degree angles;hirmine
Longevity technology a hormone , Loss of pregnancy‐associated plasma protein A extends lifespan in mice
Cheryl A Conover, Laurie K Bale
Aging cell 6 (5), 727-729, 2007
Genetic deletion in mice of pregnancy‐associated plasma protein A (PAPP‐A), a recently identified metalloproteinase in the insulin‐like growth factor system, extends by 30–40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP‐A as a critical regulator of lifespan and age‐related diseases, and suggest PAPP‐A as a possible target to promote longevity.
" An immunization against PAPP-A could be a one office visit longevity treatment that makes people, that is homo sapiens, that is humans live 30-40% longer; the analogous upside chemical (protein, peptide, nucleotide, other could also be characterized/measured at liter blood bag from a young well human successful pregnancy or eight (p values on successful pregnancy blood chemical constituents) successful pregnancies; notably the rodents can easily be administered the successful pregnancy upside (longevizing, wellness promoting) electrophoretic mass fractions their entire lives as the human/rodent mass difference is so advantageous; seeing if PAPPAS-A protein effects zebrafish and c elegans lifespan could suggest some conserved and different upside from successful pregnancy chemical that can then be tested in mice and people for longevization and wellness effects
Longevity technology, anabolic processes build tissue growth, and I perceive the opposite of anabolic biochemistry could increase longevity so molecules that look like other testosterones but block anabolic effects could be longevity drugs
It is really obvious but not on the first page of a a search engine, germline genetic engineering of people, that is humans, that is homo sapiens to make a sufficiency of their own vitamins is beneficial, this is a nice thing to do for all the other animals too
Iontophoresis of antimicrobial peptides and anesthetic peptides including opiate peptides and other anesthetic peptides like gaba receptor increase, cannabinoid increase, or nerve glutamate decreased response tail nestling peptides
Phosphatidylserine-ized acne immunogens could reduce the body's response to pimple bacteria reducing pimple size and inflammation at both 20th century regular acne and cystic acne;
cofocalized lasers could drill an into-bodyside pressure release channel getting rid of potentially scarring surface directed pressure release channels at 20th century acne, cystic acne, or any other cyst channel
Source of new antibiotics and complement: some organisms like earrthworms and flesh eating worms have, like 7 orders of magnitude of surface area that encounters infectious viruses and bacteria, for an earthworm to live a year that weighs 7 g, it has 10,000 times more surface area to mass than a human
Earthworms and flesh eating worms sensitized to human oncocytes could make immunochemicals, perhaps similar to human immune complement, with worm equivalent to linking immunoactivating keyhole limpet protein to every electrophoretic fraction of human oncocyte, like a breast cancer tissue culture cell; so immunosensitize 11 kg of worms to a human cancer, then concentrate the worms' immunoresponse chemicals to make a dose, or a plurality of anticancer immunochemical doses (kind of ignorant, but 10,000 times surface area at worms means 70kg human body mass of worms makes variously 10,000 anticancer doses or just one dose); test at mice
New localization high specificity aptamers from immunosensitized worms; one neuron type one aptamer; reactive triad
dock and release; docking unfolds aptamer or other protein, revealing or exposing enzymatically degradeable linker with fluorophore protein on it, and a drug, possibly a photoactivateable drug attached to it,
3 photon system activates protein drug, detaches protein, peptide or RNA drug, then at a brain map if the nucleus accumbens or pallidum is the main brain structure that has a D2 +TAAR1+cannabinoid receptors in a 4:8:4 ratio then colorimetric ratio brain map is possible, and a engineerable 3 photon system @ratio drug can be produced that only activates at the nucleus accumbens or pallidum is possible
Lungfish, able to hibernate 4 years at (online) something like 1/60th metabolism without physically rotting or dying of disease may have superb immune systems to develop anticancer antiatherosclerosis immune drugs like proteins with.
Gene therapy that prevents or also cures cancer; engineer the genes that are causative at producing human immune system complement
Genetically engineer complement to be anti-atherosclerosis, gene therapy as well as germline enhancement is beneficial
Cc of ambient rf antenna might be hyperlarge surface area (like 1000-10,000 different rf frequency gathering antenna, or just a hundred layers deep, depot injection of pedot antenna goop is ambient rf powered drug depot electromigration; GDF-11 microgram/numerous picograms is a longevity drug technology, as are numerous RNA drugs, like RNA drug that upregulation of the production of mTOR1 receptors (RNA drug that has function similarities to rapamycin 60% longevization at mice) as well as RNA drugs that upregulate lomgevizing AMPK, or also physiochemical cascades of metformin stimulation;
structides are possible RNA drug functionalikes, they could be GA optimized like RNA are, published as being GA friendly
Preserving depot injected RNA drugs is bolstered with published efficacy of 2020 RNAlater preservative, it is possible that cellular RNA repair enzymes (published) could be at equilibrium repair with chronological degradation of RNA, the numerous DNA repair enzymes could be genetic algorithm reconfigured to repair RNA like RNA drugs as well
what chemicals in million year lifespans endoliths are preserving RNA, those could be used to preserve drug-depot RNA drugs
hyperordered crystalline polymer RNA drug matrix; without actually histone-like spooling of RNA drugs, something like comfy-molecule-recliner zeolites could preserve RNA drugs
Or, ambient RF powers melting of a solid polymer liquid crystal to release RNA drug from liquid crystal scaffolding storage
Ambient rf could release liquid-crystal-scaffold-preserved motile sperm over several months or years at a cervical ring that voluntarily gets people pregnant with genetically enhanced sperm; similarly comfy recliner scaffolding for sperm could be possible
Epigenetic maternal side epigenetics could reduce birth defect three generations of five child families; also 130 F rabbit families moved to 90 degree, or more comfortable climates; two enzyme halvings of activity from 130 F rabbit or mouse pregnancy to 90f rabbit or mouse pregnancy do slowed enzymes/slowed construction cause less birth defects at mammals; hibernation drug pregnancy might have even fewer defects
2 Ag atoms 2^4 spin states, bec silver, bec multielectron systems, chlorophyll, BEC spin trap molecules; C, Si,Ge is it possible to find out which electron on -C:. Is the one emitting a photon; thats's 3 bits per carbon, si, Ge atom or 8 bits on an osmium atom; 64 bits per atom if there is a spintronic sensor; 8 polarization planes could be made likely or unlikely to overlap; read polarization plane with adjacent known polarization plane wave adder, or subtractor, that makes hyperdiscernable duos or groups of photons; single photon detectors exist; what, at any element or molecule is the single brightest spectral line in the spectral line database; polarizations at that element, isotope, or molecule coulld be easiest to read and detect; Nahydrborane or NaBeH could have fewer higher intensity spectral lines; match highest efficiency 1-3 nm physical size detector to highest intensity frequency emitter detector pair for measuring plural spins polariimetry of electron field simultaneously; physicist could comment that if electron tunneling stochasticizes spin, it might sparepolarity, or maybe not; when at a van der waals crystal or durable arrangement does an atom retain variously soloemittivity character as well as when does it have shared group emittivity; a van der walls crystal polymer could be a physical embodiment of 8 valence electron simultaneous polarization plane emitter on a per atom basis;
Computer software could sift atoms and molecules to find: what two orbital hybridizations mext to each other make the sufficient universal computer part (NAND) or (NOR) truth table then make computers first with AFM tips, then chemistry and nanotechnology as well as picotechnology
(new note)
[NOTE 60] Sperm preservatives for motile sperm; there is a human body tisse that with oxygen and food lives lo
Inbox
Thu, Jan 21, 1:13 AM
to me
Sperm preservatives for motile sperm; there is a human body tisse that with oxygen and food lives longest outside the human body, it is possible that this is cartilidge; a swimming sperm cell cartildge co-culture could keep sperm alive because it was nested in, and moving at a cartilige tissue matrix that could live months from passive diffusion of oxygen through polymer packaging and nutrients, this kind of live sperm packaging could give genetically enhanced sperm longer viable life in packaged forms available in mini-marts, grocery stores and online. Notably motile sperm
may be stored in the reproductive tract of queen bees.
I favor laser eye surgery for children contact lenses with longer than 30 days between changes are also fine
Ir or uv antibody colorimetry contact lensrs with antimicrobial light activated peptides gradually release; selfie sees ir colorometric contacts are doing great, just fine to leave in another 60/90/365 days phone/pc app can use any selfie ad 2020 cameras already see IR (like remote control LEDs); a 365 day between phone images contact lens great for children at developed and developing world; just get new contacts when children's eyes outgrow previous contacts; may be at previous notes but a person like a child wearing contact lenses could look into a PRK-like laser that only sculpts contacts polymer, no effect on eye tissue (THz laser also a possibility) computer calculates 20/15 or higher vision from combining imaging data of actual eye with sculptable 365 day+ continuous wear contact; this could bring vision correction to one week old babies on up; some asian nations are 90% nearsighted as children, PRK of children's contacts could treat them years earlier for better babyhood and learning
30 day contacts let 6 times more oxygen pass, so 18- 36 times more oxygen passing could support 365 day+ duration contact lens; air-hockey table like halftone dot drill pattern with perfluorocarbon that carries-oxygen as well as hemoglobin and better than water could fill drill holes
waveguide contact lens is 11-24 times thinner more Oxygen diffusive; the combination of air hockey holes and wave guide thinness technology could be 2 *11-24 more oxygen at actual cornea surface
Isotopically pure waveguide materials (like isotope fiber optic patent) could be better
Ambient rf Powered vision correction contacts or even glasses doing epaper switching to/as part of waveguides is prescriptionless vision correction
Sex toy; entire clitoral crural and vestibular body resonator: cofocal ultrasound from wand or even mattress pad sets up most pleasurable entire clitoral crura (and entire clitoral vestibule) vibrations, like resonant frequencies as beat frequencies. These could light up the entire clitoral process (as i have read it is called) or just parts of it
Bead covered condom and cofocalized ultrasonic beat frequencies, from a matteress pad the woman or girl is laying on; warming beads/lenticulars around glans at condom; the condom/warming beads could also be activated by a cofocalized ultrasound masturbation aid like the 2020 fleshlight interpretation of a vaginal canal; the warming beads could be warmed through electrical induction at the fleshlight
Pleasureable
Anal sex beads at condom glans induction warming, increase pleasure
condom/pleasure sheath Bead cline simulates: warmth passaging at in-stroke. vaginal, anal, fleshlight, or something new to me:antenna in the room activates condom bead cline of warmth or even vibration during oral sex, so oral sex with a pleasure sheath/condom on could actually cause greater pleasure than oral skin and tongue penile contact; exterior of the condom pleasure sheath could also have iontophoretic reducers of gag reflex at oral sex
I read there are people that derive physical pleasure as well as CNS pleasure from performing oral sex, supporting that is a completely different thing, when i am performing cunmilingus on a woman and get sexually excited my hips begin to move in a rhythm automatically
99.9th percentile of Automatic hip rolling motions at givers of penile oral sex among people who also say they enjoy giving penile oral sex and actively seek it out is a genetic population physiological basis of finding enjoys performing oral sex genetics, it is beneficial to put those genetics at all people, all human beings, all homosapiens germline genetics
Similar antenna powered warmth swirl at polymer membrane between clitoris/vagina and mouth; the partnerness of cunnilingus with the genetic algorithm neural network fMRI and eeg of pelvic ganglion maximised microbead warming, swirl form topoloogy, and microbead inductive EM vibration
(Motormems particles embedded in the on-vagina cunnilingus enhancing membrane; also if a person or their tongue got tired, desultory contact is pleasure membrane reinterpreted into avid swirling, vibration and warmth with very light pressure
FMRI eeg of pelvic ganglion could find higher pleasure sex toy canals and ultrasonic stimulation modes
Sex toy entire penile resonator at fleshlight
Sex toy;
Abortion resonator collapses vasculature to/from placenta 20-30 minutes of total fetal anoxia, or $1 ultrasound cleaner elements cofocalize on placenta spotted with ultrasound, to destroy placenta, notably fetus side only vasculature (abscence of blood clotting/stroke risk from keeping sonic disruption away from maternal tissues; alibaba doppler ultrasound fetal heart rate monitor $5, 7 focalized 20 cent ultrasonic cleaner transducers $1.40 so get it online abortion machine that works at all 9 momths of pregnancy could be $5-7, $3-4 volume production version and be durable so women or girls could share theirs; tuned so slightly soapy water can be used instead of ultrasound gel; 2¢ CPU always spots placental vasculature at any fetus age (50 micrometer 2020 ultrasound imaging resolution; placenta ultrasound abortion could occur in .5-8 seconds, CPU and cofocalization supports a "i have no idea where it is" rubbed back and forth motion at lower abdomen surface seconds causing voluntary abortion
Puberty and postpuberty prevention mattress topper; parents of sexually active female children of any age could get their daughters a comfy matteress layer like memory foam with a cofocalized ultrasound abortion beamer at it; scans during every sleep for an unplanned fetus or zygote then ultrasound aborts it if it finds one; affordable enough for the developing world noting 35¢ IoT headphones and $2 mosquito bednets, a mattress pad or even elastic matteress cummerbund could be 3-7 cents of fabric and 80 cents of ultrasonics, with store all the energy up and abort every 40 days 39¢ indoor photovoltaic; notably during the 20th century puberty was occurring earlier and earlier for girls and age 8-9 was newly considered nonprecocious puberty; if menarche was similarly early at the developing world then many people under 14 could avoid unintentional pregnancy; the software at the abortion producing matteress topper could also automatically compensate for multiple people sharing 1 bed causing all of them to have abortions
Sex technology; wireless inductor mattress topper or antenna in room can warm and vibrate cervical cap-like vagina "shallow-fier" it feels especially good to percuss up against the back wall of a womans vagina, and a cervical cap with a 2" long heated jell blob would do that at the majority of 20th century men; warmth-heightened vaginas are extra pleasurable; one benefit to her is that the gel cervical cap blob could be W-shaped to focus or translate his percusses to the O-spot on the back of the vagina, it could of course also vibrate with induced electricity, if that is found to be pleasurable as well, another form could be a cervical annulus rather than a cervical cap
Longevity technology apoptosis on or at non neuronal least 99.9th percentile mitochondria activity (70 g tissue) could cause tissue cell replacements at 50th percentile distribution; also causes intracytoplasmic space protein/peptide exports at weller amount; 99.9th percentile of least mitochondrial activity would have numeric similarity to screening all non CNS sites cells every 34 months, less than 3 years for rejuvenation; how many grams of tissue can it do a day? body regeration capacity determines number of grams per day of least miocondrized cells replaced; if a cell is 10-20% protein + lipids+ water, 24 grams of supplemental food protein a day is as much as 240-480 grams of possible new tissue a day; upregulating production of stem cells simultaneously is likely beneficial; to spot a 99.9th percentile least performing mitochondria
gene therapy on TCA cycle, nestle-tail export peptide blocks theoretical surface apoptosis chemical receptor
Hormeisis: 20 different tRNA mutants; artificial scarcity of each; do any of the organisms live longer
Childrens profile mitochondrial membranes with cpp on them as rejuvenating lipids; also of course the bulk synthesized mitochondrial membrane lipids/phospholipids
Are fetal as well as zygote mitochondria better as they power rapid many orders of magnitude heightened high fidelity tissue multiplication; if, as i read, elderly people during 2020 had fewer mitochondrial per cell, then transforming the mitochondria to be the zygote-like, zygote capacity mitochondria could be rejuvenating; zygote quality mitochondria could come from meauring human zygote epigenetic forms and making epigenetic modifier drugs (like peptides), also superproducing mRNA of all mitochondrial nuclear and mtDNA mitochondrial genes could produce surplus mitochondria spare parts that existing mitochondria might incorporate for better rejuvenated function, that could be RNA drug or also a gene therapy. What i think i read was that possibly 20th century elderly had only 20% the teenage number of mitochondria in their cells as human teenagers, yet both teens and elerly use within 1/4 the same amount of food calories, suggesting elderly mitochondria do 3 times as much TCA cycle work per mitochondria, that suggests new TCA cycle intermediates as foods and supplements could benefit the elderly;
~°
(new note)
Nov 27 2020 notes
Sat, Nov 28, 2020, 11:48 PM
to Be
Genetic algorithms can often make things 30 to 2 to 3 times better; To my perception the body is already filled with networked systems and perhaps it is possible to remove all or most epigenetics at something like yeast or zebrafish, then that would leave rapid opportunity for stochastisticaly reintroduced saved data as well as of course breed billions of new yeast to find out if this techquenique which is strongly supported at google scholar can create longevevity increases, If it works at yeast they can try it at zebrafish
There is a single gene difference between caucasian and non caucasians, wikipedia says, “In 1999, the nacre mutation was identified in the zebrafish ortholog of the mammalian MITF transcription factor.[73] Mutations in human MITF result in eye defects and loss of pigment, a type of Waardenburg Syndrome. In December 2005, a study of the golden strain identified the gene responsible for its unusual pigmentation as SLC24A5, a solute carrier that appeared to be required for melanin production, and confirmed its function with a Morpholino knockdown. The orthologous gene was then characterized in humans and a one base pair difference was found to strongly segregate fair-skinned Europeans and dark-skinned Africans.[74] Zebrafish”https://en.wikipedia.org/wiki/Zebrafish#Scientific_research Utilizing that single base pair difference and making the caucasian version part of the germline of all mammals, including all homo sapiens, humans, people and persons is beneficial germline genetic engineering.
There is a wonderful idea of better than well. What might this look like at neurodevelopment; I read about neural crest development at wikipeida, so what would better than well look look like there?
measuring things causes the possibility of optimal knowledge isolates (comical I’m reminded of the phrease why protein isolate) and highly forgiving traversed or iterated or the actual neural crest pathways math and chemistry, at completely well neural crest development biology mauses can guide minds to recognition of valued paths and bruit about optima, although I think true optima are possible.
It is very ignorant of of me, but I saw a thing where Bell’s inequality could be expressed with three polarizers, I am reminded of how water surfaces polarize light and a person could make a pleasant water feature (undulating or laminar) with mirors in the right places so that the Bell’s inequality polarization overlap environment is continuously updated and refreshed, perhaps with enough of these to look at, and a sufficient number of physics enthusiasts looking at them a person will think of something new to say about about Bell’s inequality
Its Novemember 2020, and some people are getting nasal swab tests
eugenol or lidocaine, nanosomal with piezoelectric element driven penetration of the anesthetic; alibaba .1c to 1c piezoelement and half cent battery make this affordable.
snort microspheres, they puff up in the nose, and diffuse an enjoyable flavor (sucralose) simultaneous with absorbing a sample of fluid. Then do single nostril nose blow to gather sample, if snortatant colorant has made saliva colored then expectorate in tube as a replacement for a nose swab.
does the: gentle q tip in the ear pleasant sensation have anything comparable to the least-pressure but sufficient to gather a nasal swab sample?, that is, is there a nasal swab experieinece of extreme gentleness and vary narrow pressure range that actually feels good to neutral? Completely unknown to me.
Craigslist activity partner: let’s hang out! I’m unconcenred about your covid-19 tatus but am happy to use one of the free testing options so you can verfiy I’m harmless.
Reading about automated and human in-the-loop helpdesk automation software, I read “Many calls to the IT help desk originate from users who just want to know what directory to save work in and which printer is the closest to them” There are software based solutions which might well be better, but the cheapest (11/2020) GPS chip on alibaba is 20 cents, so printers, such as office printers could simply have a 9 cent version of that chip producing True 3D location that people could seek out when choosing a printer.
What to call a file and where to store it: with the cloud, parallel storage, or the impression of that, of one identical file at 20-100 differently labelled directories makes it so the computer can store a new file in a location that would make most sense for a computer to store a new file in like “documents” for a Microsoft office document; As a sloppy, untutored, or heavily rewarded human I might save it to the desktop; with cloud computing, or even just version synchronization off-net and HDD, clicking “save” which then alerts people to the fact that their document has been saved three or more ways: to the desktop, at the documents file folder, and as a long-abstract-length titled file, reminiscent of a search engine search result, called a Bing it up at Microsoft environments. So you click save, or it autosaves these three versions, at least 1-3 of them will be be mentally easy to find and remember, or importantly, spot, with human recognition memory.
unicode shapes ⚮ ╗⌇⌋ ⌬⌝ ⎦ ⏖ ⏣
∿∿∿ Ⅎ ᴤ
Looks like game of life glider gun ⠫
placenta vessels based heart lung machine, notbably keep lab mammals and humans alive as long as possible, then map things that go amiss during first 400 years of sustained living
royal jelly does HDAC epignenetics, neutral version as well as inverse of royal jelly epigenenti change could be tested as to any effect on longevity, if there is none then royal jelly longevizes without an epigenentic componenent. If there is a longevization epigenetic component to royal jelly at mammals, like mouse study, then the Even Moreso variation with hyperacetylation/Hypoacetylation/hyper and hypomethylation varieties of the beneficial epigenetics tried
I was reading about treatments from calcified coronary arteries. My perception is that I read among many procedures, those that involve grafts sometimes have the grafts themeselves calcify, causing nonoptimal effects, It seems possible that a soak up the crummy stuff vascular loop could be installed and then if it soaks up 90% of the circulating recalcifiers at the cicrulatory system then perhaps the heart vasculature might only do 10% as much recalcification, contributing to wellness and durable effectiveness of procedure, very crudely, it is possible to imagine a meter long extra loop of circulatory pathway tube used to absorb some of the “calcify” instruction chemicals, perhaps the GI tract vasculature could host the extra meter of tissue culture vessel length, and, perhaps be minimally invasive to swap out periodically;
I have previously written about ways to reduce diminuation of efficacy of drugs, on their repeated dosing, possibly including analgesic or also anesthetic drugs.
The internet says things that suggest a cure for low back pain would be of major benefit, “In both 1990 and 2013, the leading causes of ill health worldwide were: Low back pain, depression, iron-deficiency anemia, neck pain and age-related hearing loss.”
I noticed once when my back hurt that if I went to sleep it was likely to feel much better and be cured the next day on waking up. So, could they isolate that “it (back pain) fixes itself while alseep” to some brain sleep stage or pattern (EEG, REM, etc) then make a harmless nonhabituating Instant nap technology that lasts 3-7 minutes to create a restorative mini-nap that gets rid of back pain. Some possibilitities that come to mind are
Nanosomal instant sleep ambien nasal spray+REM inducer, or perhaps Slow-wave sleep (delta sleep peptide) peptide + “3 minute knockout from asthma whiffer”. The idea is that you get instant sleep, of the particular kind that causes recovery from back pain if there were an entire nap.
It might be too weak an effect, but playing back EEGs causes the brain to synchronize around they played-back waveforms; an EEG head playback circlet plus an instant nap chemical could do that.
Another possibility might be TMS (transcranial magnetic stimulation) that does either instant nap/nod off plus an optimal to back recovery sleep mimetic peptide.
If there is a messenger RNA profile of narcolepsy then that could be made into an RNA drug that causes instant sleep, again with the purpose of an instant micronap solving lower back pain just like a real nap.
The TMS focalization that causes P-zombie effects thing I saw published. could be another thing to switch on for 20-40 seconds to see if a P-zombie nap cures lower back pain, particulalrly, as like the other technologies, when combined with an EEG drug, or perhaps better, a drug that causes the EEG-like waves of a normal well back/spine. sort of like an electrospinalogram.
Botox may be effective against small back pain, the internet says, “Botulinum toxin A has been tried as a treatment for chronic low back pain . Although this practice is experimental and not well tested, it has shown promise. For example, in one small study of 31 people with chronic low back pain, botulinum A injection was compared to saline injection into painful back muscles. Pain relief was reported by most people as lasting 3 to 4 months.” That brings up the possibility of an ultraffordable topical cofocalized laser activated version of botox for back pain. The person applies the drug delivery (nanosomal, DMSOish, many others) topical botox, which is then only activated with light at tissue depth from a light emitting patch. As a technology the person with back pain would just get the ointment and photoactivating LED patch as a product at the grocery store. The botox could be photoactivated with a wide variety of published technologies, and a porphyrin moiety attached to the botox protein is just one of many numerous possible technological approaches.
The internet says there is a working topically applied specific area muscle pain ointment, I do not know how this works, but that localization through ointment rub-in location suggests that a lower back or other back areas topically migratory and effective photoactivated botox could also be effective. This could be a very affordable solution to back pain. The actual picograms of botulism toxin per dose is very affordable, and the $1 store has a 4 LED elastic toy wearable product. On alibaba that is likely 5-9 cents for the light emitting elastic wearable, and 1 cent or less for the photoctivateable (porphyrin) botox
I thought it could be beneficial to think of treatments, cures, and preventatives for heart disease, includinging atherosclerosis and heart attacks.
Hearts with less regularity and more chaotic attractor aspect are published as being healthier. That is the high variability chaotic attractor heart is weller longer. It might be possible to create a pill that nudges a heart to prefer the strange attractor math region. A big pill with lots of little pills in it it, each of which contained stochastic 1-.05 Hz dosing of something that harmlessly effected cardiovascular things (vasodilators, vasoconctrictors, stimulants, stochastic hawthorne active ingredients) such that there was a beneath the threshold of personal awareness chaotic nudge once every 1-5 seconds, this could causes an unwell heart to switch to a chaotic attractor program many many times each day, then they could measure to see if this reduced illnesss.
Perhaps the micro moment CA (chaotic attractor ) pill with bodyside only of the blood brain barrier active ingredients causes similar effect, completely excluding the nudges to chaotic attractor mode from having brain (feelable) effects.
It is possible that as a solution to menstrual cramping, or cramping with an IUD contraceptive, that a transcervical implant or IUD could have botox as a diffusive ingredient, which could be measured to see that it gets rid of menstrual cramping.
Wikipedia says 60% of people are absent ever experiencing low back pain, monozygotic twin studies could find the genetic basis of complete immunity to lower back pain, it is beneficial to make complete immunity to back pain a part of the germline of homo sapiens, that is humans, that is people.
somewhat analogous to changing the location of a needleless epidural anesthetic procedure 1.5 cm to a new location everyday for a month would keep any one location from from wearing out while still providing blockage of backache
Wikipedia notes that most people rapidly recover from small back pain, this brings up the possibility of geneticially isolating the equivalent of small back pain in agricultural animals, then breeding/engineering groups that recover from the veterinary equivalent of small back pain in 5% the median amount of time. The most parsimonious genetics of rapid recovery can be traced to particular genes and mRNA, then mRNA drugs based on that can be generated then tested to see if they make recovery much more rapid at median responder verterinary animals to see if these could also be RNA drugs that relieve human back pain with high rapidity.
longevity technology research area, online it says, “a hibernating groundhog's heart beats just five times” [ a minute], they could raise groundhogs in an environment where they hibernate 90% of the time time and another 0-10% of the time, then they could see if the long hibernating groundhogs had markedly longer lifespans than the 0-10% hibernating groundhogs. If they do, then groundhog (rodent) similarity to mice could be used to engineer a 90% hibernating mouse from groundhog genes and then the mice characterized as to why they were living much longer hibernating 90% of the time. Messenger RNA profiles (of eiher groundhogs immediately or 90% hibernator longevized mice) could be used to make RNA drugs to test to see if they make non-hibernating mice live longer and the RNA drugs, if any, that cause mice to live longer are then tested on age batched groups of marmosets (primates) to find out if this is a n RNA longevity drug that benefits primates; if it does it can be tested on age batched groups of human volunteers to see if it causes greater human longevity absent any effects deleterious to humans.
If groundhogs that hibernate 90% of the time live notably longer than groundhogs that only hibernate 0-10% of the time then they could also do a connected circulatory system parabiosis procedure linking a 90% hibernating groundhog to a 0-10% hibernating groundhog. If the 0-10% groundhog lives noticeably longer then they can find new chemicals (proteins, peptides) at the shared circulation that cause greater longevity and possibly wellness. Although several longevity parabioisis chemicals are published, this could be a completely new type, and be made into a human longevity drug.
What does it mean to actual things when a math system is particularly attracted to a 4th spatial or chronolological dimension? distribution outliers are favored perhaps, or just possibly poission distributions spontaneoueously make themselves prominent (sort of become a most frequently found vertice), if delayed quantum choice eraser retrocausality is true, what would combining its math and physics with a 4D time attractor math, and actual physical embodiminent do? The internet says, “These chaotic states are bounded by paths that form attractors, where the specific path is determined by initial conditions, much like the oscillation of a pendulum. However, whereas the damped pendulum attractor is a single point (the lowest point), attractors of nonlinear dynamical systems do not converge to a single dimensional point, but to a different dimension in three-dimensional space – a fractal dimension. Attractors that have a fractal dimension are known as ‘strange attractors’, so basically what if you just upped the math to make 4D starnge attractors, after you then know what they might look like from the equations you can look for them in nauture or build them. Finding 4D starnge attractors in naure could find many new phenomena. at measured systems, these might look like data that has a strong, not otherwise obviously sourced avoidance of regression to the mean and normal distributions. This could look like a distribution with a much higher amount of outliers. If a 4D strange attractor is prior knowledge about a system then perhaps it becomes (bayesian)
This one is kind of unlikely but they could do longevity (and wellness) mammal parabiosis math studies, where all the actual measureds are used to come up with a stack of little math models that, among other things, describe the math of the benefitting connected partner. those specific little maths could be used to design new drugs with. Let’s say at parabiosis the cardiostrange attractor of the benefitting mammal becomes more fractally variable, previously published as cardiobeneficial; or perhaps the benifittor becomes more circadian responsive (even in the absence of melatonin)
detect angina before it is ever felt
EDTA solution as keep alive solution for postvehicular accident hearts, measure calcification at 30, 60, 90,120, 300, 365 days prior to transplant to see if chelation actually does anything beneficial to cardiac tissue; the internet
A variety of lab mammals are used to model human atherosclerosis (2020), it is possible a longevity treatment published as causing greater, for example, rodent longevity grants the rodent models sufficient extended lifespan to better model atherosclerosis. So, if centrophenoxine is causing rodents to live 30-50% longer then they have that much more lifespan to develop atherosclerosis, and then can be used to develop new antiatherosclerotic drugs. Deprenyl at 24% greater longevity may also be beneficial, as could genetically modifying rodents to make more GDF-11 protein (I think I read female mice that overexpress GDF-11 live 47% longer). The combination of a longevity drug with a wider new area of testing out antiatherosclerosis drugs and gene therapies could be a beneficial new research protocol.
A kind of sideways approach to a new antidepressant and possibly anti-atherosclerotic is, noticing that stress causes macrophage activity that causes plaque build up and rupture, do something with the immune system that reduces, but to within normal range, macrophage activity; I may have read that when antigens are placed in some kind of phospholipid packaging or moietyization, that the person actually becomes less allergic to something they were previously sensistized to. If they made a pie chart of all the the things a normal person, as a well as an atherosclerotic person, as well as a depressed person are immunoreactive to then compare these three, to make a subset list, that provides a briefer list of things to do a possible immunopassivation therapy about, to decrease atherosclerotic reactivity, and also reduce the atherosclerotic stress from mental nonoptimality (stressy personality; depression).
Using a genetic alorithm to develop immunopassivation molecules and moieties; Note 100-1000 endogenous immunoreactive chemicals, then do a a kind of combinatorial phospholipid where the potential passivating moiety is a single variant on 1000 versions, such as length, liposomal anti-innumunogen passivation.
The internet has numerous immunopassivation and antigen desensitization drugs and protocols online.
immunopassivation (phospholipid moiety) of toxoplasmosis gondii antibodies could have mental health benefits (reference: the connection between cats and mental illness), reducing nonoptimal mental effects of toxoplasmosis gondii.
Shift (night) work is associated with less optimal health and possibly even nonoptimal longevity effects. It is possible using monozygotic twin human volunteers that that one could simulate shift (night) work, and the the other could continue day based activities. Immunoreactivity profiles of the two styles could be made, and then if there are any differences in the specific things new antibodies are made to either day/night then they could test an immunization to either mop up the deleterious shift work chemicals at the circulatory system, or immunopassivate (phospholipid moiety) existing antigens. Noting these shift-work chemicals are deleterious, it could be that even among day active persons immunizing against them, noting they may already circulate as a baseline, provides additional health and wellness benefit possibly a better than well effect.
As a new drug delivery method I have not ever previously heard of an injectable (airjectable) fluid or gel at the sublingual area. Advantages are much hight non-metabolized absorption, and the 1-12 month durability of a gel depot. Peptide drugs could beneficit from this.
Iodine sufficiency one dose treatment could be bellybutton depot airjection anywhere. about 1/10,000th of a gram is dialy iodine sufficiency, so a one gram depot injection could supply 3 decades of iodine, or being more engineering friendly, a 1/2 medium depot injection covinging 67% of USRDI sufficiency could provide two decades of iodine sufficiency;
The possible structural variations on phospholipids is likely more than trillions, notably at the phospholipids that have already been researched some are actually good for people (phopshatidylderine), Using yeast and microfluidics to mass screen phospholipids to find those that are even more beneficial to people is I think possible; as previviously described GFP yeast can accumulate more GFP the longer they live, and flow cytometry can then find the most optimal (greatest longevity) yeast treatments at about 10 million yeast screened per minute. During 2012 1 million or more c elegans could be flow cytometry sorted per 24 hours.
endolith phospholipids, rapamycin phospholipids, totoise phospholipids
comparative robustness of pubertal sperm and eggs cytes compared with supercentnerarian sperm and eggs; the difference between the two could have some kind of preervative factors;
stagnant water that is not stagnant, there are things called micyrhizzial communities where biotic communities have durable beneficial effect. I was thinkinging that ponds could have the same thing, human slecected microorganism mixtures that make the wateter safer to drink if a mammal drinks it. optimally people would treat their water first before drinking, but a 1/100 of crummy stuff precluded could make water treatment require 1/100 the infrastructure, making it 100 times cheaper (sort of; piping pumps) to treat. a green algae genetically engineered to glom what would otherwise be an essential nutrient for a pathogenic bacteria, perhaps lactoferrin made at algae or duckweek could preferentially utilize iron, keeping other bacteria from growing. risk of eutrophication, and staged ponds, (optimized pond scum ecology makes pondwater 1/10-1/100 as risky as it would otherwise be
shaker flashlight ice cream churn, ph swing
cox 2 immunization might make everything less achey and fervid, thinking of both milk cows and all mammals, “Mastitis has cost American dairy industries an estimated $1.5 to 2 billion per year in treating dairy cows (wikipedia)” It is possible an immunization to cycloxegenase II and I enzymes could reduce mastitis, making the lives of dairy cowsmore enjoyable. At humans, with safety testing, lifetime immunization against cyclooxygenase I and II could reduce incidence of cancr as well as reduce any joint achey or feverish symptoms throughout the lifetime.
thought the lifespan.
crispy duckweed naPCA
some fungi are deliquescent, purification of those chemicals, dependent on positive flavor, could be made a part of duckweed, and possibly be more deliquescent than NaPCA. selective breeding for most deliquescent edible gene product (such as genes trasferred from fungi) makes a duckweed or duckweed like plant that doubles volume every 16-24 hours that spontanteously turns to liquid when harvested.
g, like IQ genetics BDNF has numerous SNP versions, creating a completely new BDNF SNP could be tested at rodents and marmosets for greater cognitive ability, then this SNP variant of the BDNF gene made into a reversible human gene therapy, then upon further improvement is made an intelligence enhancing part of the human germline at all homo sapiens, that is people.
It is pretty simple to think of, ut it might have a longevity effect: Besides pineal chemicals that effect circadian rhythyms there are other chemicals that effect circadian rhythms (irisin), these could be tested on mice to see if they have a longevization effect noting the 20% longevization from melatonin supplementation at rodents.
a variety of species may have different circadian rhythm adjustor chemicals, which may be with or without any circardian effect on mammals like humans, these circadian rhythm adjustor chemicals could be tested as longeveity drugs.
The first human clock mutation was identified in an extended Utah family by Chris Jones, and genetically
characterized by Ying-Hui Fu and Louis Ptacek. Affected individuals are extreme 'morning larks' with 4 hour advanced sleep and other rhythms. This form of Familial Advanced Sleep Phase is caused by a single amino acid change, S662➔G, in the human PER2 protein
are there fungi with unusual circadian rhythms? like different spans, they could try these novel .5-1000 hour circadian rhythm chemicals out on c elegans and yeast to find out if any of them lengevize.
circadian rhythm chemicals in 400 year lifespan tortoises that are not in mammals are another possible place for longevizing chemicals to be found at.
I read that banana plants are 60% anologous gnetically to the human genome, nad plants have circadian rhythms. Making the circadian and ultradian rhythm chemicals (like proteins, possibly others) that plants make then feeding them to C elegans could find longevization chemicals.
Also, I read two things, one is that the difference between a perennial plant and annual plant can be as few as three genes (the internet), and then there is the other different area of how a plant on a certain light schedule can be made to be perennial or annual, it is very simplistic, but feeding c elegans perennial proteins could have a longevity effect.
a better version of a circadian rhythm gene could have the opposite effect of shift work, possibly reducing cardiocascular events; the very daytime version could be tested at atherosclerotic mice to see if it reduces cardiovascular events, this could be a beneficial improved gene to place at the human germline as it confers better than well “very day shift” effects.
saffron vision
gratitude journal discussion with Bob,
genetic algorithm wells30%-300% better effectiveness based on helicopter rotor beams and wind-power rotors (300%)
perhaps people would be waterborne illness resistant if their stomachs prouced enzymes that denature, zap, or otherwise neutralize proteins and microorganisms. Sources of these illness resistance chemicals could alsoready be at high concentration in other species, then gene therapy used to make them to be produced at homo sapiens. Vultures, hyenas, raccoons, crows could also be species that sustain their health over decades even though they eat rotten food; the technology here is that they could test detrivore/omnivores to find out if they have have stomach or gi tract enzymes, such as proteolytic enzymes that kill bacteria, perhaps cyst forms, as well as denature (make harmlesss) bacterial toxins. The bacteria/virus/cyst terminating enzymes then become water purification addititives (10 mg/gallon), as well as can be made a beneficial part of the human germline.
Wikipedia describes how proteolytic enzymes have been bred and engineered from bacteria. These biologically produced proteolytic enzymbes could have a big new wellness side branch, a proteolytic protein and spore denaturing material where a droplet placed in a gallon of water sterilizes the water. The protein then denatures at human stomach pH to be harmless and sensationless to humans. So, as a n example, you could just get 1-20 gallons of pond water, a 1-20 drops, wait 7-20 minutes (analogous to cold water “laundry detergent” proteolytic enzymes duration of action) then drink the water. “laundry detergent” proteases are only about $16-20/kg at alibaba, suggesting a new custom version that produces potable water could be, at 10 mg/gallon , 2c a gram is just two one hundredths of one cent to purify a gallon of water. As described these would be new bred/engineered proteolytic enzymes with an empahsis on sterilizing water and making it potable. It is beneficial to develop a proteolytic as well as bacteriolytic virolytic and sporolytic protein based enzyme that is producible at the stomach or also human GI tract as a gene therapy. This would cause untreated water to approach much fuller potability when drunk by a human being and benefits people.
Noting Dave Pearce’ Hedonistic Imperative and Abolitionist Manifesto there is a strong basis for genetically engineering all organisms with neurons to make GI tract proteolytic enzymes that make water potable for every species with neurons, as these all benefit from increased wellness.
biologically based sources of laundry detergent enzymes as water sterilants, either, amazingly, at the human GI tract, or as a golden rice/golden wheat/golden corn ingredient.
quats with thiosulfate, .0005% of a quat sterilizes water, then thiosulfate or some other (ph buffer)thing denatures quat, very high efficiency water sterilization; there could be a particular molecule quat where stomach acid defunctionalizes the quat, making drinking quat-sterilized water harmless
Bow head whales live more than 200 years. thinking about the possibility that bowhead whales might have different atherosclerosis, of some form that permits diving blood pressure effects, repeatedly, that could be thought of as figuring out puff and compress at bowhead whale vasculature, does it preclude cardiovascular plaque break-off and CHD, if so, what about bowhead whale CHD makes for the wider latitude greater survivavability vasculature. This could possibly be made into a gene therapy for humans to have, possibly along with just less or no atherosclerosis, but if if atherosclerosis were to occur it would be the bowhead whale kind.
Tortoises (400 year lifespan) and bowhead whales (over 200 year lifespan) might get pneumonia, at up to 400+ years, how do these organisms
CPP to lungs from circulatory system brings anti-pneumonia drugs, and possibly mucolytics preferentially to lung tissue,
I think I read that some nonhuman organisms that maintain the same mate decline if their partner organism ceases living, trace this to any of 100 different neurotransmitters and possibly even EEG effects, then come up with a better than well and partnered neutrotransmitter booster drug to test as a longevity technology to see if it causes greater longevity
There is some kind of thing where mountain and prairie voles partner up or do not partner up, but can interbreed, measure to see if they have differences in survival after partner nonaliveness; if they do, then figure out the difference in the longer lived variety to find out the mechanisms of precluding partner mediated deleterious lifespan effects, and find the biochemistry of better than partnered longevity effects.
LKM512 yogurt is published at about 2 studies as causing 80-90% lifespan increase in mice; give LKM512 yogurt to atherosclerotic mice to see if it causes greater longevity even with a non-cancer atherosclerotic mouse model
there is a DNA methylation thing called an epigenetic clock, I think may others must have alreaddy considered editing this clock as a way to increase lifespan. could the corpse of a superenteneratian, 99.999999% of the cytes as which, or more are still fully functional, extend or refute the methylation clock? Or find the places on it it, the actual tissues, that matter (neurons, vasculature)
its not cancer, its point of specificity tissue disregulation (hints of epigenetic clock going amiss at .000000000001% of tissue causing say atherosclerosis
genetically engineered-in anti-ischemia harm peptides as testable longevity drugs at atherosclerotic mice
mouse dorm n=40k, what causes a bruise to be scavenged successfully away, rather than treated as a body interior multicm dead tissue that could float out and cause strokes effect?
do the genetics of least bruising have any relation to cardiovascular wellness genetics? IS there any relation to longevity effects? Least bruising of human MZ twins correlates with what wellness benefit?
volunteer process, ultrasonic zapper bruises 1 cm tissue at 100k human volunteers with parents ages 70 on up. Correlate parental survival and lifespan with child non bruisability, advantage, basically harmless to the 40-50 year olds at experiment.
Pills that stop bruising may be longevizing, there may be a reduction of “microetherosclerotic” effects benefit as well.
“In one study, patients suffering from pigmented purpura — those deep purple bruises that get progressively worse — that took 50 mg of rutin (oral rutoside) two times per day along with 500 mg of Vitamin C twice a day were completely healed of their bruising within just four weeks.”, “hesperidin can dramatically reduce bruising and strengthen your capillaries”
60 second reactive stent, 20 seconds better
f=MA microsurgery, 2mm golfball core elastics can do 1.8 mm suturing at 90% mechanical engineering efficiency.
just explore the HOX and other state space to find completely well nonhuman primates with 2-3x the volume, span, and reach, of coronary arteries as regular primates, verify they are almost immune to lethal cardiovascular events from network and path duplication at the corononary vasculature.
should they just put in two hearts?
right handed heart people
apoe e immunue to ath at germline
Ok, so the source of tissue culture can be exceptionally well tissue, it is even possible that exceptionally well tissue with its epigenetic meythylation clock reset to age 1 could be the basis of transplant tissue.
One way to tell excpetionally well tissue culture tisuue is to use the velvet plate cuplication process; a tissue culutre plate with say 1 billion cyctes at it (vascular epithelium, or better, stem cells) is velvet copied, then the copy frozen (or quiecently maintained), then at the 1 billion cyctes on the source plate actual particular to the human physiological stressors are introduced. For example, blood plasma concentrate from an elederly person might contain the things senolytics get rid of, as well as diverse but nonoptimal immunology, like immune sensititizations; other challenges like hypoxia(ischemia) that would terminate 90% of cyctes, and 99th percentile of cholesteric plaque adhesion. So after one of the velvet prints has 99.9999 mortality, the physical locations of the million cells (stem cells, or differentiateds) that surviced all that are known, then tissue culture is accomplished from just those million cells most likely to thrive and survive found via the physical mapping to the velvet copy base. They would then verify that tissue culture from these 1 in a million best cells actually caused better survival and function at implanted tissue culture constructs, like vascular material, cardiac repair stem cells, and even neural tissue grafts (treating mental things). If it is possible to grind away an atherosclerotic plaque, then spackle the area with the 1 in a million perkiest spackle cytes, then overlay them with a planar tissue made from the 1 in a million perkiest planar tissue cytes, then the repairs addressing cardiovascular disease are likely to be better.
As a possible longevity wellness technology it could be possible to find the “weakest stuff” at a person’s personal tissue sample, then cure it, then deliver the cure to the entire person’s living body for greater longevity from strengtheninging what otherwise would have been the weakest parts. Culture the 99.999th percentile of feeble, (say resistance to ILGF-1, or nonresponsiveness to Nitric oxide, or then cure it, then administer the cure to the actual human where 99.999& of the cells are doing better
Some people, when they exert themselves, experieince cardiovascular events, even while exercise has preventative effects on CHD, implant notices when the person’s physical exertion (and associated things like blood oxygen levels and blood pressure) goes into 1 per 10,000 likeliness of causing cardiovascular event then the implant releases instant destresing, blood pressure reducing, respiratory function optimizing drugs, this is then lifesaving per some number of automatic activations; Opiate peptides might destress, vagus nerve agents, if there are any, might deepen breathing, other peptides could reduce blood pressure.
So this brings up the research question, how many minutes before a heart attack is a heart attack preventable? Do you have to get there 5 minutes early or 30 seconds early? Do sensations radiating along one arm precede a reversible process, or do they indicate an actual heart attack process? 5 minutes early suggests a wearable, like a smartwatch, that magnetically stirs up and opens chemical reservoirs (drug depots) at an injection site beneath it.
The internet says ”The most dangerous times for heart attack and for all kinds of cardiovascular emergency — including sudden cardiac death, rupture or aneurysm of the aorta, pulmonary embolism and stroke — are the morning and during the last phase of sleep. A group from Harvard estimated this risk and evaluated that on average, the extra risk of having a myocardial infarction, or heart attack, between 6 a.m. and noon is about 40%. But if you calculate only the first three hours after waking, this relative risk is threefold.” That suggests that the smart watch that activates drug depots to prevent heart attacks might actually find itself working about 1/2 the time while the person is unconscious in the morning before waking.
One advantage to a magnetic drug depot smartwatch that measures physiologogy and dispenses drugs may be that it addresses the (I pereceive I read) 1/3-1/2 of peopel who have a first heart attack without any medical warning. I do not know what medical warning means, but I get the feeling that it means people who feel healthy, without angina, without prior cardiovascular surgery (atherosclerosis), Have a first and lethal heart attack. Family history could be a guide to whether these people would do well to wear a heart attack preventing watch above a certain age even with a normal physician’s physical. Also, if you omit ever needing it, it omits ever getting used.
“wiggle melatonin” could reduce heart attacks. Noting the connection between circadian rhythms and heart attacks (quoted) it could be that a multimodal distribution of melatonin taken before sleep, rather than a single main dose of melatonin could cause the first 4 hours (highest heart attack risk period) to have some quantitative difference in the likeliness of having a heart attack. Also, there is now a melatonoin-similar-molecule antidepressant drug they could screen to see if it, or, it at certain dosing schedules, reduces risk of heart attack.
There are also nonpineal human circadian rhythm mechanisms and drugs. I read about irisin, whcih effects circadian rhythms, perhaps there could be a heart attack preventing nonpineal circadian rhythm drug.
Epithalon is a pineal hormone, and it is published that humans (over 70?) on epithalon are twice as likely to live six years longer as those not on epithalon. Epithalon could prevent heart attacks.
17%lifespan increase tropical rainforest sounds during heart attack sleep am, measure reduction; stay alsleep massaging bed during am risk period.
“greater than 50 percent more heart attacks in winter months than in summer months, and it's mostly about stress”, combine that with 40% more AM heart attacks and that suggests that studying the physiology of people during summer afternoons could represent a mere 10% risk. So, using rodents, or another heart attack model experimental mammal, inject the rodents with one-previous-heart attack human AM winter blood chemicals, and human PM summer blood chemicals (from one previous heart attack paersons), find out if there are specific circulating factors in human blood/plasma that cause heart attacks in rodents or other lab mammals, interestingly there is the possibility of concentrating the plasma chemicals 10 or 100:1 to get a stronger heart attack production signal. Immunizing aaginst any of these chemicals, if novel, could reduce heart attacks in humans.
if there are specific circulating factors (AM winter) it is possible liver enzymes naturally get rid of them, upregulating those liver enzymes with a pill then reduces the AM winter chemicals, reducing risk of heart attack.
tissue culture staples and roof shingles, tarps oooh gross, or vasculature advantage(?), the tomographed skin tag or wart, possibly from the persons own tissue culture.
Glaxosmithkline: headache reliever pill. Some people chew pills, having planes of cleavage so that the pill fractures all over the place, but always (usually) at a micrometer thin delicious flavor plane turns a yucky chewed NSAID into a tolerably flavored or even flavor treat headache relief pill that works much faster. The flavor cleavage planes could also have hygroscopic (pulls water from surroundings) micrometer coating to form the rapidest micrometer slurry. Better to use a flavor enhanced liquicap though if that is faster at pain relief.
Dwelling air warming, cooling, and transport could be improved as to its effect on indorr air quality. Indoor air quality is likely linked to a reduction in risk of disease possibly heart disease, there is a chance improving indoor air quality reduces risk of heart attack. Noting first four hours of the day (and winter) are greatest risk for heart attacks it is possible indoor air quality duing that time makes a bigger difference. Is there a benefit to producing summer evening psychrometrics (humidity/temp) during winter AM? It is a broad slice, up at 6 am, at work at 10:00, but suggests indoor air quality at communting vehicles could matter a lot, At the dwelling, just running the fan through the air filter 2-4x as much between 5:00 am and 8:00 am could be beneficial,
Indoor air quality and psychrometrics might be particularly testable at nursing homes. Just modifying the settings to a different variety of “normal” (summer evening) at 100K of aggregate residential facility could show a strong data trend rapidly.
There is a chance that summer evenings are actually good for cardiovascularly ill people, rather than it just being ab absence of AM events during winter.Find those beneficial things, then trry them out all year, one possibility is pollen, another is antidepressant long days of summer; better data would be better, I associate winter with rain, others associate it with snow, I perceive places it snows more, the people who live there live longer; rainy winter season from physical rain might be more deleterious than ice season. Psychrometric testing opportunitity.
well lit dwellings summer circadian during winter could be tested to see if they reduce cadrdiovascular events
(circadian rhythms of summer) gene therapy or daily responsive but once annual or less often depot melatonin injecttion could reduce cardiovascular disease. One set of numbers is 50% less heart attacks during summer, and also melatonin or a nother circadian rhythym drug could preclude first 4 hours peri-rising (40%) heart attack risk factor. with a one office visit injection to get the multi-year depot injection/implant
Is hibernation or things like estivation a source of calm and possibly sleep, that might work on completely different neurotransmitters than GABA? If so then this could produce beneficial new harmless sedatives and anti-anxiety drugs. They could take a rodent that does true hibernation, and connect it via parabiosis to a non hibernatining rodent to see if the non hibernatining rodent calmed down, was sedated or also had the brain scan of lack of anxiety. One possibility is the the hibernatining squirrel/rat or beaver combination, another possibilility is testing the groundhog
“While hibernation has long been studied in rodents (namely ground squirrels) no primate or tropical mammal was known to hibernate until the discovery of hibernation in the fat-tailed dwarf lemur of Madagascar, which hibernates in tree holes for seven months of the year.”
circulatory factors of hibernating animals do things to alert animals, “Hibernation induction trigger (HIT) is somewhat of a misnomer. Although research in the 1990s hinted at the ability to induce torpor in animals by injection of blood taken from a hibernating animal, further research has been unable to reproduce this phenomenon. Despite the inability to induce torpor, there are substances in the blood of hibernators that can lend protection to organs for possible transplant. Researchers were able to prolong the life of an isolated pig's heart with an HIT.[36] This may have potentially important implications for organ transplant,”
smartwatch magnetically releases hibernation induction trigger https://www.annalsthoracicsurgery.org/article/S0003-4975(97)00631-0/fulltext “HIT” (or maintenance) chemicals if it detects 1 per 1000 likeliness of cardiovascular event that hour, interestingly it may be possible to combine this benefit with a mild wake-up chmical so the person is able to do something other than pass out in response. bodyside and well as brainside varied chemicalcs could also contribute to heightening surviviving and normalcy after cardiovascular event; bodyside only “HIT” (Hibernation induction trigger (HIT) obtained from serum of certain winter-hibernating mammals, such as woodchucks, 13-lined ground squirrels, brown cave bats, and black bears, can induce hibernation in these animals, even when summer active) At humans, with a smartwatch drug depot this could be continuouous low level medication for those projected to be at cardiovascular risk without impairing mental function. HIT studies are from 1997 and could be updated to see if it is possible to make RNA drugs and peptides that do the same things as the HIT chemicals, thought at the time to be opiods (like opiate peptides)
As a technologogy to get rid of heart attacks, HIT chemicals could be made to circulate at the body during the first 4 hours (most lethal), as well as during winter. Perhaps bodyside only would do it, leaving people’s minds fully functional in the AM. Also, the article mentions opiate receptors as HIT life-preserving drug receptors. I read there are more than 100 neurotransmitters, so perhaps there are other non opioid HIT chemicals that can be found with serum between lab mammals experiments.
Also, they found a primate (nearer human biochemistry, mRNA) the fat-tailed dwarf lemur that hibernates up to 7 months a year, along with opiate HIT, these lemurs may have other serum chemical systems that could benefit humans, particularly at redicing cardiovascular events or making them less serious.
Along with the article URL, that concentrates on treatmentless ischemic hearts having about about 30% their original capacity on survival, and 15 minute pretreated (bear serum or opiates) hearts having 69-80% original capacity this brings up the possibility of using HIT hibernation chemicals to measurably reduce the effects of strokes or even routine surgical anesthesia on mental functioning.
Under hibernation, Wikipedia mentions sharks can go three hours of ischemia, so shark serum could also be tested on cardiac and strokelike ischemia to find new drugs that minimize the effects of heart attacks and strokes.
As a possible technological improvement to the 1997 HIT paper, cell penetrating peptides could concentrate all of the traversal of active drugs (Bear serum simililar chemicals, opiate peptides) to specific organs, for example, heightening concentration at the heart and vasculature, making these drugs more dose efficient and possibly better tolerated.
A one dose approach to a drug that increases the survivability of cardiovascular events (heart attacks) is: tail squiggle gene therapy, photoactive installation just at the heart: Describing that, basically receptors, like opiate receptors have receptive components (one mental reference is g coupled protein receptor swirl fingers) as well as a base area (before the fingers) some authors call the tail that does not directly glom the the thing of interest. This tail area can however have a custom peptide or protein made, that gloms to it, that causes the actual receptor part (fingers) to be more or less sensistive. So engineering a peptide that causes heart opiate receptors (or bear hibernation serum chemical receptors) to be unusually easy to activate and causes them to stay activated could cause continuous “on” status just from normal circulating levels of endogenous (natural) chemicals as they are primed to prefer to be on. One way to get the tails to have the perma-on peptide attached to them, or, perhaps more optimally, just be developed from stem cells with the “easy on” protein sequence and conformation conformation part of their makeup is is phototherapy gene therapy: Using published methods gene therapy only takes (does its thing) where tissues are illuminated, and at a person, cofocal lighting lights up the heart for the duration of the gene therapy installation. That causes the opiate receptors (or also bear hibernation heart chemical survival receptors) to be the only things at the body illuminated/eligible, at that particular treatment, for updating with the new genetic form.
Hibernating Arctic ground squirrels
female polar-bears go into hibernation during the cold winter months in order to give birth to their offspring.
What restarts a cardiovascular event heart? They could put that chamical at the magnetic stirred drug depot smart watch that prevents and responds to cardiovascular events.
circulating null epinephirine with enzymatically cleavable null part then turns to nor epinepherine restarting a heart if the magnetic depot releases a bunch of the enzyme.
radical: EM quarter squeeze a supercapacitor to make a super big current pulse; sequential reaction, 2 supercapcitors, the first em squeezes the second, the second supercapacitor when squeezed has a much accellerated or rather concentratated current pulse. pro IC technology MEMS like size defibribillator,
I have not hard of a defibrillator that installs custom, “ultra high survival” waveforms, perhaps the MEMs duocapacitor could do this as well.
“presented with the shockable rhythms of ventricular tachycardia or ventricular fibrillation (better outcomes)”
People at cardiovascular risk could have their IoT lightbulbs watch them for cardiovascular events. at Quora one person writes, “The most treatable situation is where the event is witnessed, 911 activated and bystander CPR provided. In those cases, we get about 80% to the hospital alive and about 55–60% discharged from the hospital in normal or near-normal condition.”
That suggests that volunteers trained in CPR at various kinds of dwelling buildings could be IoT (Internet of Things) called to suddenly go to a strange apartment with freshly (IoT) unlocked doors to rescue someone before the paramedics can get there. I’d do it, that is I would get CPR certified, then let my neighbor’s computer call me to their assistance to do interim CPR before the professionals arrived.
The cable box anti-heart attack drug flinger and pro-survival taser, expanded to the in commuter vehicle version: I think it is possible that at halfbakery.com I posted a technology about how the home media center (20th century words: cable box) could have a camera that watched the people on the couch in front of them, using things like digital themography of the face to see how their health was. It could spot if they were having a heart attack and then the cable box could discharge (fling) eentsy ninja-shuriken drug injecting at the person’s neck to deliver lifesaving chemicals (drugs), possibly like the ones EMTs (emergency medical technicians) give to people they are reviving, or things like DMSO(drug delivery)-aspirin splashballs, Something better than tissue plasminogen activator, and, having read more recently, possibly the the chemicals at hibernating animals (hibernating bear blood serum chemicals, opiate peptides) that cause (30% functional ->80 functional) greater function survival in heart-attack hearts. The in-vehicle (car) version makes sense as well. A very simple modification to that makes it work better, put it at the dashboard of the vehicle. Airbags are already common, and heart attacks in motor vehicles on the driver’s side (and with oblique shuriken aim, passenger side) could possibly be very near the lifesaving rescue use numbers of collision airbags. The numbers are very approximate, but 2020 800K heart attacks, compared with 30.2K (2010) lethal vehicle acidents, (800k/24 hours, 33K heart attacks during a period of driving 1 hour each day. Note that the 33k heart attacks is spread across the entire population of drivers. If the motor vehicle had an Anti-Heart Attack Drug Shuriken Flinger (AHADSF) only at those over 49 (actually math of a graph with crossing lines could find the optimal age to have an anti-heart attack drug shuriken flinger (AHADSF) installed at a vehicle) then the person could just get that as a standard option on their motor vehicle when they were getting it >49.
Also, there is an opportunity for higher quality of diagnostics than “having a heart attack”, for example, if the radiating one arm sensations that may(?) precede a heart attack can be detected with digital thermography of the hand and neck, then 5-15 minutes of advance notice is produced to fling the drug shuriken ahead of time. Similarly there are optical (laser) only ways to read blood pressure from the eye, and it is just possible that photonics of the face, or through-skull photonics could detect angina. Benefitting this technology is autodriving vehicle technology (driverless cars) which could take over for a person who is on the verge of a cardiovascular event but does not know it, or a person having a cardiovascular event.
One thing an in-vehicle heart attack response technology can do is do a good job imitating an EMT (emergency medical technician), with technology at the steering column able to push out a contact surface that can do CPR compressions, and another item that extends (or shoots, perhaps like a taser) from the steering column that does electrical defibrillation.
https://www.everydayhealth.com/atrial-fibrillation/noninvasive-vagus-nerve-stimulation-shown-to-reduce-atrial-fibrillation-in-post-operative-patients/ "Electrical stimulation of the ear and the vagus nerve that sits on the surface there has a calming effect, in that we are stimulating the largest nerve of the parasympathetic nervous system [part of the autonomic nervous system] and hence the corresponding antagonists," Martin Andreas, MD, lead author and an associate professor in the department of cardiac surgery for the Medical University of Vienna, said in a press release.
For the study, researchers divided 40 postoperative patients into two groups: one-half received LLTS while the rest were given a placebo. The patients who received LLTS for five days post-surgery had a significantly lower incidence of developing atrial fibrillation — 4 patients out of 20, compared with 11 out of 20 in the control group.
“The autonomous nervous system controls the heart rate and influences the threshold for cardiac arrhythmias,” Dr. Andreas said. After surgery, the body is under stress, dealing with inflammatory reactions and oxidative stress, and the sympathetic nervous system — the body’s fight or flight response — gets activated.
This increases the likelihood of developing atrial fibrillation, which affects 1 out of 3 patients who undergo open heart surgery and can lead to further complications.
“Patients who had an episode of atrial fibrillation are more likely to develop another episode and are frequently kept on anticoagulant medication, which increases the bleeding risk and may increase long-term complications,” Andreas said.
A previous study, published in September 2017 in JACC: Clinical Electrophysiology, found that vagus nerve stimulation had a positive effect on incidences of atrial fibrillation post-surgery, but researchers used an invasive device that was implanted inside patients’ bodies. This study shows that a noninvasive option could make a similar positive effect with fewer potential complications.”
As an adjunct that reduces death from CVD vagus earlobe or throat stimulation could be based on a wearable battery pack, with a wireless charging pad on bed. Other published things online have descrbibed how people are at greatest risk of heart attack during the first 4 hour hours or morning (approximately, that includes about an hour of sleeping), it could be that vagus stimulation could have anti-heart attack beneficial AM effects. Similiarly vagus stimulation could reduce cardiovascular risk during Winter (50% greater risk) as well. Perhpas the vagus output of normal well people during summer evenings could be prompted to be produced with a vagal stimulator at the unwell and this could contribute to fewer heart attacks.
I perceive I read some people are not sure if they have had a heart attack or not, perhaps a medical diganostic chewing gum with antibodies that change color could tell people if they are having a cardiovascular event that immediate attention would benefit. The general instructions might go like this: “You have a family hisotry of heart disease and various biomarkers suggesting cardiovascular risk. If you feel funny, chew this gum. If it changes color immediately seek medical assistance even if you feel fine.” This is a actually very affordable, compared to a (color/antibody) $1 pregnancy test, 1 piece of gum a month (the worried well) for three decades is only $360 for a person to test themselves at will if say their hand feels funny or if they get dizzy.
Longevity technology, This one is a longshot. I read that at different times of the human menstrual cycle women are much better at smelling odors than other times. I also read that the abilitity to discern odors is predictive of whether a person will be alive or not. “A 2019 study published in the Annals of Internal Medicine found a link between a poor sense of smell and mortality. Researchers from Michigan State University analyzed data of over 2000 older adults, between the ages of 71 and 82. As part of the study, participants were asked to identify 12 common scents such as cinnamon, gasoline, and smoke. Researchers then tracked each participants over the course of 13 years. As they found, people who identified less than eight different smells were 46 percent more likely to die 10 years laetr. So researchers concluded that a poorer sense of smell could predict death.”, so drawing plasma from young women at their monthly height of odor detecting ability, then administering the plasma fractions as drugs to elderly mice could find out a longevization diference between most effective smelling times of the month plasma administred-as-drug and least effective smelling times of the month plasma-administered-as-drug. Then note the chemical differences between the two plasmas with their different longevization abilities (if any), to find the specific plasma chamicals that are causing the mice to live longer. Make synthetic versions and administer these human chemicals (proteins, peptides) to age batched groups of human volunteers to see if the pro-smell plasma chemicals are longevizing to humans to make a new human longevity drug.
another approach to finding a longevity drug from the human smelling acuity test is to find out the people who could smell just 1 or zero of the scents, and see if their 10 year mortality was above the published 46% for those that smell less than 8 of the samples. If the zero/one smellers are hypermortality-prone then their blood may carry toxic chemicals that when administered to mice cause mortality. The sources (specific plasma proteins) of that chemically transmissable mortality can be found, and then immunizations to those chemicals produced, and the immunizations tested on mice and humans as longevity drugs.
Another way is to make a longevity drug from supersmeller blood plasma: find the 99.99th percentile of both males and females able to discern different odors, then make blood plasma fractions from a donated 2 pints of blood then inject mice or rats with the plasma fractions. Noting the 2 pint volume to mouse or rat dose volume ratio One human supersmeller might be able to dose 300 days of rat possible longevization from 1 pint (600 days from 2 pints), or several thousand days of mouse dosing per pint of human plasma.