Treon Verdery <treonsverdery@gmail.com
Longevity technology:
How many sequential doses of an epigenetic drug cause the epigenetic improvement? Liposomal depot, perhaps attached to an antibody that gloms it to the surface of the lining of the lymphatic compartment could diffuse beneficial drugs, although that seems complex. One possibly as is epigenetic modifying drug palmitate. I do not know if the longevity effects of 10HDA(10H2DA) are from HDAC interference and epigenetic, but if they are then taking a high dose of 10HDA once a month (or some other interval), or like 30 grams of royal jelly which has 10HDA(10HDA) for two or three days once a month could have the same or better longevity effect. There is the possibility that occasional high dose 10HDA(10H2DA) or royal jelly is actually more longevizing from being thorough and of higher activity.
One HDAC2 inhibitor is a nootropic. It is possible that one or two high doses of that HDAC inhibitor a month could
Cause greater cognitive ability.
Notably though there is another version of this. I read histone epigenetics like acetylation can change rapidly, perhaps in minutes, although the other long view also makes sense as people get epigenetics from from their parents or even grandparents. I perceive I read there is longevity epigenetics people get from their parents so a couple days of epigenetic dosing could cause greater longevity effects the person's entire life. A couple days of epigenetic modifier dosing could even cause their children and grandchildren to have greater longevity. At the nootropic HDAC2 inhibitor that causes greater cognitive ability, a couple days of HDAC2 inhibitor dosing could cause intelligence enhancement that is also passed along to children and grandchildren.
Cognitive ability genetics: the genes that the published cognitive ability heightening HDAC2 inhibitor modifies could be g (like iq) intelligence genes. SNPs, alleles, and copy numbers of those genes could be enhanced at the germline or with gene therapy to increase intelligence at humans, that is homo sapiens.
Longevity technology:
I perceive piperine causes greater absorption through the membranes of the GI tract from telling them to be more permeable. Is there anything that could be placed at liposomes along with the active pharmaceutical ingredient (ÅPI) which reach the lymphatic system to make the lymphatic membranes more permeable? It could be piperine again. That lymphatic permeability drug could make other drugs, like rapamycin, rapalogs, or other longevity drugs to be 2-4 times as effective at reaching tissues from the lymphatic system. Combined with the 2-10 times greater effectiveness of drugs that skip first pass hepatic metabolism that could make rapamycin, rapalogs, senolytics, or other longevity drugs 4 to 20 times more active and affordable. Rapamycin that makes mice live 60% longer could be just 12-14 cents a dose based on $40/gram at Alibaba.com .
GSK (Glaxo Smith Klein) has an online page where they request technology ideas. They make Tylenol and some other antipyretic pills:
ela–naproxen (ela-n) is ethynyl liposomal active transport naproxen it is active at about 7.6 micrograms. They could put a dot of it on the outside of regular naproxen pill that is enteric coated so there is an immediate action antipyretic at the stomach but it also activates 11 hours later so one pill lasts 24 hours. Another way to do it is like multiminipill contac™ with ela-n microenteric coat so it dissolves better at the small intestine after 11 hours. Another way to do it is rather than a 7 day palmitate have ela-n attached to a different alkane COOH like perhaps C6COOH
To make another, delayed dose to make 24 hours of naproxen activity, that could do 36, 48, 72 hour one pill dosing as well: Another way is ela-n of three or more types taken simultaneously where each ela-n has a different enzyme-reactive group on the ela-n with a passivating group removed by the enzyme. The enzymes that remove the passivation moiety are enzymes at the circulatory system. The first ela-n gets its passivation moiety removed first and the next ela-n gets its passivation moiety removed next like cumulatively 90 minutes later, then do this with a sufficient elan-enzyme-unpassivated-moieties to get a smooth 24 hour, 36 hour, 48 hour or 72 hour dose curve.
Years of arthritis relief from one office visit: A depot drug form of ela-n, ea-n, which I calculate as having a 7.6 microgram 12 hour dose could put ela-n at an implant (3 year nexplanon-like) with just 16.64 mg of API at the implant. Sensibly and obviously omitting the 2-4 times dosage multiplier enhancement from liposomes, ae-n could be a 33 mg or 66 mg entire API content implant. I think it is possible to make much longer lasting depot implants or even injections, so a decade of arthritis relief from a decade functional implant at one offive visit is possible.
Complementing a decade functional arthritis relief implant is putting the longevity and life preserving peptides AEDG (epithalon) and thymosin at the implant. Epithalon is published as causing 24% greater longevity in mice. The combination of epithalon with thymosin, at intermittent dosing, is published as causing people to be four times more likely to be alive after six years. Epithalon and thymosin are peptides so it is possible screening libraries of variants on these peptides could find versions with fewer mcg per dose.
Another ela-n 24-96 hour antipyretic: put ea-n on the outside of the pill for immediate relief. At the interior of the pill layer, make the 11 hours later dose with dry liposomes that have different numbers of concentric layers at the liposome molecule, so like the 11 hour dose has 11 concentric layers of liposomes ======Ö on it.
It is possible to simplify the ela-naproxen molecule to ethynl naproxen, or ethynyl liposomal naproxen. Ethynylizing sex hormones causes sex hormones at FDA drugs to go from a.625 milligram dose to a 600 nanogram dose, a one hundred times amplification of effect. A cell membrane active transport moiety causes 1000 times greater transport than diffusion. Either of these alone produces microgram active doses of naproxen.
A really simple version of 24-48 hour liposomal naproxen without ethynylization or active transport moieties is to use the way liposomes avoid first pass hepatic metabolism to bring 4 times as much regular naproxen API to the circulation. If that works on regular naproxen that makes a 24 hour dose fit in a pill half the size or at a full size pill up to 48 hours of antipyretic anti-arthritis effect. Dry liposomes could be used.
Longevity technology:
Multiple simultaneous drugs at aged batched mice are a way to make longevity drug API identification faster, and make mouse research as much as 120 times more affordable to produce a p value. Matrix simultaneous drug administration is published, and creating batches of mice, at 8 mice each, two months or less apart in age creates 48 mice, with each duomonthly increment able to generate a longevity increase p value longevity drug. The 2^3 deaggregation mice as steps to find the actual drug that longevizes is a way to do this. Sequential mouse experiments to locate the individual most effective longevity drug, possibly after data on 2-6 months of simultaneous administration of the drugs to new age batched groups of mice. The actual longevization pct of each batch of mice, starting at the first two months p values, continuing to 4 months and six months also gives a number on how much longer the eight and ten month and year interval mice would have to live to continue that particular mouse' longevity gain. This is similar to calculating course grades mid term to find out if a person can still get the grade they prefer, at mice this is how much longevity increase would numerically justify continuing that drug at that mouse for greater than the amount of longevity from other chemicals that have been screened or exist. One API drug longevity quantification; after 4 months you could tell if an Epithalon peptide sequemce variation being screened was 60% more or 60% less longevizing than regular Epithalon. At 4 months you would be able to calculate that the 6 month mice would have to show an 80% gain from the previously measured effects from an age specific effect (like start midlife to cause longevization) to raise that molecular version of epithalon's longevity effect to equal or exceed Epithalon. Similarly if a molecular variant of Epithalon is 60% more longevizing at two or four momths then a side experiment can be started with 8 mice to get a p value on the more effective version. The 8 mouse chronologically colocated experiment can also be raised to eleven mice so three can be used for things like biological samples, psychological testing and other things that accelerate longevity drug development like coaministration of another longevity drug, likely one with a high likeliness of having a different complementary mechanism
sort of like calculating a school grade mid term to decide to keep taking a class
This batched matrix longevity drug protocol can be used on other species as well. 96 well plate fish are vertebrates, age batching can be accomplished on-location without a breeding facility. I have read about fish with a 6 month lifespan, causing the longevity test batches to be either 14 days or a month apart, causing either one month drug characterization or 42 day longevity drug characterization. This also provides the opportunity to medicate the fish before mid-life to explore and find new mechanisms, and measure young behaviors on the longevity drug.
it is also possible to do age batched matrix longevity drug characterization on c elegans. The lifespan of c elegans doubles at some published protocols from 30 to 60 days. The thirty day span can be divided into ten 3 day batches, and the matrix batched longevity increase percentage can be calculated from three age batches in nine days. It is possible that a 96 well plate technology could be enhanced to use computer vision and an acoustic transducer, or just a speaker, perhaps at deciHz (tenths of a Hz) and silent to humans to do the same touch the c elegans with a probe to see if it moves, verifying it is alive in an automated and contactless way.
The near camera automatic sonic probe physically motionizes the c elegans, contactlessly imitating a physical probe. To be less annoying, an intensity that 99.999 percent of c elegans will respond to but not louder is possible. Optimally the sonic probe has a focused beam of less than 1/16th of the plate well area so when the c elegans responds to it the c elegans gets immediate absence of probe stimulation. The sonic probe wiggles the c elegans slightly, causing c elegans initiated motion that is a computer vision detectable motion at the c elegans verifying it is still alive. This replaces a human with a probe and supports full automation of the longevity drug screening process. Automated pipetting could be used to administer a fresh dose of the test chemical. Automated pipetting could also be used to rotate out the water periodically to keep the c elegans well and also at standardized drug concentrations.
I think it is possible to place one to four c elegans per plate. At just four c elegans per plate, i think the p
Noting it is possible to get a p value of .01 if the statement has that much mathematical latitude, " they are still alive", and that the computer vision system can measure 3-7 things simultaneously, with a general enough statement like "the c elegans is above the first standard deviation (compared with normal c elegans) at some automatically measured characteristic" on things like: velocity the c elegans moves when acoustically probed, distance and swimming style of the c elgans when probed, amount of tropism to or away from a laser illuminating part of the well, food enrichment response, possibly even the effect of pipetting another brief-action drug like a neurotransmitter that causes a behavior into the well's water, any visual indicators that change with age at c elegans like skin texture, gonad size, heart rate. Also it is possible to quantify c elegans neurology. Genetically engineering the c elegans used at the screening to have fluorescence of brain based regions or neurons having different emissions spectra fluorescent proteins that the c. Elegans has been engineered to produce. Genetically engineering different parts of the brain or neurotransmitter specific neurons characterizes which systems the longevity drug version being screened could be benefitting. Camera gathered data on which parts of the brain activate in response to a standard harmless stimulus (food, laser, as well as the camera recording the prior to single utilization of the acoustic probe. Each of these, and others has a statement with enough latitude to get a p
Genetically engineered c elegans that indicate their youthfulness can be produced. A fluorescent protein like green fluorescent protein is engineered to be made at the brain as well as separable organ systems like heart, liver, nerves, gas exchange permeability structuress then the size and possibly the activity of these is automatically quantified with the computer camera and compared to preexisting data on young c elegans.
The value of matrix testing the drugs and the effect on the velocity of creation of new longevity drugs: also, notably the highest performing molecule screening matrix group could be considered a compounded (multicomponent actual treatment) drug in its own right. If a rapalogs covalently linked to a AMPK activating peptide combined with a senolytics and an RNAi drug causes much larger longevity increase then it is ok to consider that hroup as one treatment at the mice.
Mouse poop and saliva contain circulatory fluids, indicator chemicals, and mouse cytes that could identify separate complementary longevity mechanisms without disturbing the screening mice. This is a way to heighten the effectiveness of matrix characterization of the longevity heightening from longevity drugs, and, sometimes their combinations, if that is meaningful (note 214 year old whales and mice have almost the same systems, as do million year lifespan endoliths like algae or fungi, as does 40,000 year kings holly with 3650 day trees, so pansystem longevity drugs have validity in their own right while tissue and organ specificity, and things like body compartment, and lipophilicity/hydrophilicity also have comprehensible value, noting senolytics tissue localization, and deprenyl which concentrates most of its effects at a brain area called the substantial nigra, as well as the octopus living eight times longer if it does not have a sex gland (the value of specificity is vivid at the octopus, if there were a "I can tell I have a sex gland" receptor blocking molecule then that one specific molecule, possibly at a particular physical location would cause eight times longer lifespan. That compares with rapamycin effecting mTOR everywhere to cause 60% greater longevity, though also at humans eunuchs live 19 years longer so localization at just a few grams of tissue could also be a human longevity drug.
As a sample that can guide the mouse longevity molecule screening the c elegans or fish matrix screen to generate 99.9th percentile molecules. The three mice out of eleven to do psychological testing and get biological samples from, do positron emission tomography at, as well as matrix combinations that match or combine a brain concentrator with a heart concentrator, are places human cognition applied to the drug matrices can occur, augmenting the simplicity of just mass screening with humans figuring out previously unknown mechanisms from screening successes like finding chemicals at endoliths that longevize mice, and humans basing new drug cores to mass screen variations of.
Drug companies might make a multi chemical ingredient drug based on the effects of the matrix combinations that have the fewest side effects at mice, notably the 3 mice out of a group of 11 (where the other 8 provide a longevity heightening % with a p value) and the most appealing 96 well plate fish physiology measures, like brain and heart similarity to young fish, and including fish progeny well being
Industry competition and publication multiplication: it is possible that when one company gets particular valued results from mass screening a particular kind of thing (endolith or clam chemical variations) that other companies or people that publish do, that there is then more activity in that area, like rapamycin's proliferation of papers and people making new rapalogs, or the 8 papers on the beneficial effects of decanoic acid esters (like 10HDA(10H2DA) and HAEE) effects, this could be treated very simply as a math multiplier of the amount of molecules being screened, if 43 99.9th percentile new longevity chemicals are found then perhaps they will cause 200 new longevity 99.9th percentile higher quality drugs to be produced.
Age batched mice at matrix experiments could possibly be complemented with age batched matrix experiments on marmosets. Marmosets live about 18 years and are a primate with a genome more similar to the human genome. With the most longevizing of the 99.9th percentile and greater mouse longevity quantified, it is possible to get data from marmosets in 2-3 years; midlife marmoset age batches, like 16, 14, 12, 9 year old marmosets, could be characterized to see which longevity chemicals most nearly track along with the benefits seen in mice, that traverse a previously documented progression of benefits most similarly, likely things like reduced heart disease, reduced cancer occurrence, and brain function that is maintained or sometimes improved (rapamycin is nootropic, decanoic acid variant HAEE benefits mental health), it is possible, perhaps to quantify preserved cardiac and brain function, and possibly (possibly otherwise) cancer occurrence decrease at the drugged marmosets that are age batched, optimally the drugs become part of the pharmacopeia people use long before the marmosets get old, but when the marmosets do get old enough to have quantified long lifespan extension above unmedicated marmosets that contributes to the preference for that previously introduced drug, and things that might occur, like the pct of marmosets that avoided ever getting heart disease, cancer or cognitive impairment before a ratioized equivalent of a 114 year old are published, which let's people know about quantified complementary benefits of the drug. The effect of mouse like physiology response being quantified at age-batched marmosets between 7 and 9 years of age or also 14 and 17 years of age being much higher or also nearly identical focuses drug company products around chemicals that will most predictably work at humans.
Marmoset-mouse response similarity tracking also guides companies as to which longevity molecules are particularly beneficial at primates, and so possibly humans, and which have applicability to other areas of medicine and larger usage volume and profitability, noting profitability causes more beneficial longevity and other use drug creation and distribution.
What happens when they feed rapamycin as well as other longevity drugs to octopus? I perceive i read that an octopus that does not have a sex gland lives eight times longer. After octopus sex gland removal rapamycin's effects at lifespan of octopus that have a sex gland compared with no sex gland could be quantified, Octopus lifespan and tissue youthfulness physiology changes from sex gland removal could activate shared homologous genes between octopus and human, suggesting proteins that heighten longevity that could be new longevity drugs. That also suggests that deleterious gene activation at the sex-gland-having octopus, and that the human homologous versions of these octopus sex-gland activated genes could be producing deleterious things at normal humans just living. That suggests that epigenetic drugs like area specific methylases could decrease sex-gland-having octopus' shared homologous gene activation areas activity, bringing the human gene activation and gene product amount nearer to that of an octopus without a sex gland. This would be tested on mice.
Gene products (like proteins), and any circulating chemicals different between sex gland having and octopus absent a sex gland could be proteins and other chemicals that if immunized against cause greater longevity and healthspan at humans. If there is an obvious decrease in any chemicals at a sex gland having octopus compared with an octopus absent a sex gland then those chemicals could be administered, supplemented, at matrix form to age batched mice to find out if those chemicals have longevising effects in 2-4 months. Things that decrease activity of the human octopus homologous genes that activate because of the sex gland, compared to, if there is such a thing, octopus puberty, could also be longevity drugs. Epigenetic modifiers of octopus sex gland networked human homologous genes (methylases and others) could cause greater longevity and healthspan at humans.
They could implant an extra sex gland in an octopus and quantify and qualify the even higher activity than background at an unmodified octopus' human homologous chromosomes to find the particularly likely to be active epigenetic drugs (possibly methylases) and immunizations against the deleterious things that are even more detectable from an octopus having two sex glands to be longevity drugs.
Preventing birth defects: find the mammal with the fewest birth defects or the rodent with least and most birth defects, particularly noting the genes turned on during prenatal development; at the rodents, then find homologous genes and SNPs at humans to find human gene products (possibly circulating proteins) to decrease or increase, to be most like the mice with the physiochemistry of least birth defects.
It could be possible to breed mice with rates of birth defects 1/7 the to 1/16th that of wild mice; at the outdoor mouse dorm have the feeding station computers have an ultrasound probe that automatically scans any mouse that comes to eat, pregnant mice with malformed mouse progeny would accumulate at the database and then their well progeny sterilized. The mice would, as I read mice do, have about 9-11 pregnancies per year and the new baby mice could get pregnant after a month, the feeding stations could also remove non breeding mice from the mouse dorm, after 365 fays of only defect less mice breeding it is possible there would be a % decrease in the number of birth defects, the mice would have a well baby genome that could be compared to the genome of the initial mice with possibly a few locatable genes that caused the reduction in birth defects; homologous genes and SNPs could be found at humans for both less than median and more than median defects; any difference in circulating physiochemical produces a group of chemicals that could be screened to find out if their use as drugs would decrease birth defects, or if epigenetically upregulating their production decreased birth defects, and endogenous chemicals that were associated with birth defects could be immunized against as well as epigenetics like methylation used to decrease the amount of their production. Along with the genes the actual SNPs, alleles, and copy numbers associated with either direction (imaginably the 3rd and 97th percentiles) at mouse genes with human homologous genes could be looked for at human gene databases, like those of health organizations, to find out if human variations on those birth defect producing or birth defect preventing genes had strong numerical associations at humans as well, the human physiochemical differences between the 3rd and 97th percentiles of birth defect rick as suggested from the mouse genes (notably the newly found birth defect reduction genes) would provide a human physiochemical identity source to derive new birth defect preventing drugs, immunizations, epigenetic modifiers and germline gene modifications with. If a human woman had genes that carried risk she could do a cheek swab, have stem cells produced, the deleterious genes changed to the more beneficial defect decreasing versions, then conceive a child with the engineered oocyte which would also reduce the risk of birth defects at all of the human woman's progeny, this is also an opportunity for the woman to enhance the rest of her child's genome.
What would be really amazing is if there were two strains of interbreedable mice, one strain having 1/7 to 1/16 the occurrence of birth defects, the genetic difference between them looked at to find out if there are human homologous genes, and, perhaps the nifty birth defect preventing thing, notably different SNPs, alleles,and copy number variants between the two strains that have similar genetic variations at humans or at humans' particular specific homologous gene versions; at SNPs at two different genes that are particularly active prenatally, the mice with less defects could have a particular two SNP difference from other mice, at humans it is possible some pct of the population has two of the SNPs, one or none, they could measure the amount of birth defects at the humans to find out if those SNPs made a difference at humans, then go through the homologous genes' mouse-human SNP difference (further away from or nearer to each of the mouse' varieties(number of different SNPs; which variety version of mouses multiple snps, are there)) one gene at a time, simultaneously looking at a big database of different human genomes and comparing it to the mice, matching mouse and human SNPs, alleles and copy number variations to humans that gave birth to unwell persons; that finds genes that if engineered to be at mice, can be quantified as to how much birth defect risk they produce then drugs and epigenetic regulators and immunizations and gene therapies used to decrease birth defects at humans.
There is the pleasant possibility, without anything I have heard of to suggest actuality, that the genes of birth defect preclusion (found at the mouse dorm mice) could actually enhance baby wellness causing normal babies to be slightly better than well or to thrive more. There is mathematical support for this, if the number of birth defect reducing genes is near 29 then there is a certain likeliness one or more of the genes is beneficial to the human, perhaps they make more of one beneficial amino acid, have the super high productivity version of a DHA (omega 3 fatty acid) gene, or a hox gene variant that has extra fidelity when transcribed, or liver genes that are 99th percentile at metabolizing risk causing xenobiotics, or maternal genes not just of placenta sufficiency but 99th percentile of placenta optimality (perhaps a differing group of genes or SNPs that variously optimize size, vasculature (notably micro vasculature), development velocity (hormone sensitivity); the genes that availablize nutrients from the mothers body like calcium, phosphorus, and iron could have well baby enhanced versions, the genes that do quality control, like when a woman misses her period for just one month because there was a defective blastocyst or zygote and the quality assurance physiology terminated it; making it so one out of two birth defects were prevented but rather than half of women having sex get pregnant in 7 months, half of women got pregnant when having sex for 9 months, or at the womans option she could either get pregnant almost immediately with assisted reproductive technology or take a pill, or get a depot drug, that caused her to have just 1/3 the chance of birth defects while causing such heightened quality assurance physiology that it took an average woman 19 months to get pregnant. It is also possible the pregnancy quality assurance phenotype and genotype could be made more effective with drugs or gene therapy while minimally effecting the amount of time to get pregnant; SNPs and alleles of the pregnancy quality assurance process, where I think i read but might misremember, that about half of all blsstocysts (or possibly zygotes got naturally terminated at a normal 2019 woman's body, that process if it has to do with quality assurance could be adjusted to heighten quality further.
Dominant along with other, simultaneous multirecessive genes that do the same thing, reduce birth defects, would persist at a population even if there were things that effected various genotypes
Breed different mouse strains to be as similar as possible while presenting the half as many defects difference
Find the primate with the least presence of being then utilize that as a physiological experimental animal, feelingless p-zombie as much as possible. Notably this could be a particular genetics at most or several different primate species, noting there are humans that say they aren't conscious, find the most p-zombie genetics at numerous species then breed or make physiological experimental animals as well as milk cows and egg chickens and caviar fish
Noting human eunuchs live 19 years longer, screening a few thousand sex hormone variations at 96 well plate fish to find 1-100 that longevize without changing behavior could produce a longevity drug screenable on mice. 17 alpha estradiol's published longevity effects at mice without feminizing effects could be a hint.
Prevent birth defects with mice human homologous genes (genes that are highly similar between humans and mice),
Find mice or other mammals that have half or 1/4 as many birth defects as humans then compare homologous genes between that species, mice and other species with figure-outable defect amounts, comparing the multispecies SNPs drift towards or distanceingly from the homologous genes' snps of that species with half or 1/4 the human 2019AD defect amount, and where it is possible the human SNPs, alleles, and copy number variants variety that correlates with both being most similar to the 1/2 or 1/4 amount of birth defects and any data on what reduces human birth defects, as human fetal and baby wellness this guides which SNPs, alleles, copy numbers and epigenetic reduces birth defects at humans the most
The difference in proteins produced between the mouse varieties with different defect amounts could be well baby causing pills or also genetically engineered grains, milk that make the proteins that the mice and humans with the wellest babies have, it is also possible to measure peptides, organics, other chemicals at the two mouse varieties with homologous human genes and quantify those as birth defect reducing supplements
Variety of hyperwell normal SNP at human homologous genes compare big human database then feed normal humans enteric protein drug pills, genetically engineered food with the defect preventing protein or peptide that is beneficial, do gene therapy or also modify the human germline to have enhanced occurrence of completely well defectless babies
To benefit humans as rapidly as possible the two varieties of mice development of well baby supplements goes well with making a database of about 900 nonhuman primate pregnancies in the US and Europe each year and a tissue sample library, the difference between birth defects between humans and other primates can be used to create well baby producing supplements, if humans have fewer defects then the very similar homologous genes would show which proteins humans are making more of that benefit babies, it could be that even more of those proteins as supplements to human mothers would reduce birth defects even more, producing a birth defect reducing pill, food, gene therapy or germline modification
Does Epithalon with ththymosin prevent birth defects or cause more babies to live
Intelligence gene, on phenylethylamine I wrote 44 pages of technology new to me at a notebook, not on phenylethylamine i might write half a page, the genetics of the Trace Amino Acid Receptor TAAR, notably how many TAAR receptors there are per cyte and where, neurologically, like brain anatomy, they are located, as well as the number of other neurons that connect to them, connectionality amount versions providing, possibly heightened stimulation and even multineuron network effects like new neural quorums or quorums with new tropisms, are all genetically addressable, from one measure of cognitive output 44 pages of new to me technologies, i am 88 times more behavioral psychology measurable intelligent, subjectively the generative intelligence of my mind's contents is perceptibly much higher. I take phenylethylamine about 100 to
200 minutes after 5mg of deprenyl an mao-b inhibitor that makes the phenylethylamine work better; the genetics of TAAR, the SNPs, alleles and copy number variants could be compared amongst those measured to have an IQ over 200, as well as those thought to do the most creative and widely applied work
P zombie until modelled, then model advises consciousness form, p zombie tries consciousness form and heightens or mildifies isness as they prefer while being aware of the highest quality research on the difference it makes in their behavior, if they like the projected behavioral future then they do that amount of presence of being; among numerous possibilities a person might find out a projection it might matter a lot when you ask, also i think children exist, allowance to charity apportionment
One per ten likeliness of thinking of something
Genetically engineer people to be the larger of the 9.99999th percentile of creativity (divergent thinking test) who are mentally well and at the 95th percentile or higher of psychology psychometric of subject twice or more creative than treon verdery while treon verdery is on 700 milligrams of phenylethylamine which has been preceded 200 minutes previously with the MAO-B inhibitor deprenyl, 5 mg at 70 Kg; creativity benefits people. Humans generally with simultaneously utilitarian effect, creativity also has economic value and its money value per person measured amount can be quantified at variously an individual person, the person employed, the person volunteering, as well as geographical subsets of the population like areas of shared language or geography of values or beliefs that concentrate at a population at personthe greater amounts of creativity Creativity, 11 things, new gofundme curing malaria, economics eq
Just getting it, a psychometric measurable different than big five, possibly g, mbti at me it has many forms, the part of my mind that thinks of whole ideas, often science, technology, invention, traces of engineering, and at fortunate occurrences mathematics, sometimes a combination of near romance crushlike feelings and ideas about what to do when raising a daughter, that just getting it instantly, that take paragraphs to explain what I just instantly got the realization part of being of/at a person that likely is also genetic; notably though other people just getting it might be walking into a party, realizing something at a place of employment, "thinking they know the romantic actuality", online and webpage things, making art, music, the shared, psychology psychometrics is amount of any particular person at volume and frequency (amount of times per 24 hours), whether the thing they just get is enjoyable (inventing things is enjoyable, just getting it about the meanings of live interpersonal social networks could be fun or neutral) there could be a better word in English than , inspired awareness, insight, sometimes, but variable amounts, a moment with the usual amount of presence of being or slightly more presence of being with awaremess, like actual do you notice the light coming into your eyes or not, presence of being with non presence at surroundings kind of like chizmemhali flow; I think it is possible to find a genetic basis of just getting it then beneficially making the 99.999th percentile of just getting it be specified and part of the human genome making it so all people can have the mental occurrence of just getting it, also having it frequently; from a psychometric perspective just getting it has components;some would include accuracy where it can be measured, like arriving at a party and just knowing what's up, inventing a thing with the intent it functions at least enough to have mental or even actual physical beauty and often utility, manufacturability, and commercial value, and with even traces of engineering content (materials were named, possibly, but not necessarily some math, even mental math occurred, this is instant just getting it which is different than procedural, perhaps explanatory kinds of sentience), there might be humans that have just getting it at raising children and it might be possible to figure out if their just getting it was accurate based on how the children turn out, another area of the psychometrics of just getting it, is percentage of just getting it that causes action, this could be a momentary thing, like commenting on the internet, "universities have intellectually enriched daycare" when a pregnant person says something, an inventor rewrites notes so they are adequate to send as email to a company, a record producer invites a particular musician to a studio, or an engineer realizes they can look up a completely different part and then look the part up, another psychometric component to just getting it could be heightened multihour greater presence of fMRI of heightened subjective well being (happiness), that is, they have just getting it experiences, does that cause heightened well being, and for what interval, I do not know the amount of interval that is optimal, I get about 40 seconds of thrill after just getting it, and the just getting it part is kind of emotionally neutral with a tinge of comfortable wordless attentiveness, the emphasized thing though is psychometrics and other measurements of just getting it and the connection to greater amounts of just getting it at people which also simultaneously brings with it opportunities to heighten accuracy, subjective well being, frequency of behavioral actions based on just getting it, notably it is possible to think about and remain calm in the face of raising all of these to their highest simultaneous level or, possible favoring a particular psychometric describable or measurable over a group effect; causing a modification to the amount of just getting it could be accomplished with gene therapy
and the person thinking about changing their actual just getting it way of being would likely benefit from computer simulation as a guide, as well as a kind of paint-matching color palette of drugs, nootropics might heighten accuracy, anxiolytics or music might cause the just getting it feeling or experience without actual content, stimulants (possibly TAAR receptor stimulants) might increase frequency, actual action, and perception of value, so those are the kinds of things a simulation could do, possibly even aligning a persons mind, and adjusting the magnitudes and locations of adjusted activation and duration of activation at neurotransmitter specific maps like spin labelled fMRI, positron emission tomography, and something that may be possible, using a quantum camera variation on 3D brain reading lasers and software like that of Deep water (company started near 2019) combined with absorption of photons at one photon area that ate quantum entangled so they inform a quantum camera while doing spectroscopy at specific chemical brain chemistry, uv/or specific databases of stimulation frequencies and emissions spectra say what a chemical is when you beam a stimulating, or absorbable spectra beam at a chemical or neuron, or tracer contrast agent at the brain, and then use the outside of head sensor at the quantum camera to note where it absorbs and how much; very narrow emissions line stimulating, multiple separated unmistakeable frequency numbers emitting quantum camera so a particular chemical is 90th percentile at absorbing say 7 narrow frequencies each that are UV/ir published lines and regular tissue only absorbs 1 of them and at median amounts; you send quantum entangled blue and green narrow band lasers into someone's brain then only at those locations where the simultaneous two frequency (blue and green) absorption is 90th percentile does the software say 99th percentile of likeliness this neuron contains (example)AMPA chemicals, noting it is a quantum camera system (New Scientist magazine) the absorption of the quantum entangled photons is readable outside the brain completely without a reflective path
two electron system
spectroscopyreport on absorption
Options to turn on options and expansions of capability from gene therapy as well as ways to restore pre gene therapy form
Halogenated dry liposomal ethyl. (halogenated)fluorophenibut centilipoate the 100 mer lipid making alkane like moeity makes one oral dose last much longer, a palmitate, C16 fluoxetine palmitate, I imagine more than a month activity per dose. I perceive I read about an oral drug that lasts much longer than 7 days so that technology is available as well, liposomal ethynyl fluorophenibut or other halogenated phenibut causes a decrease of paranormally sourced IT pattern awareness, reduces the number or paranormal recruitment offers i experience, and blocks most of the voices i hear in my head i think are paranormally sourced, decreases paradlia as well
Another way to make a GABA active drug to block IT pattern recruitment and awareness:
Attach an antibody to a protein that is gradually, sectionally taken apart by an endogenous enzyme, the antibody could be liposomally surrounded and enteric coated so it is absorbed from an oral dose, snorting it could also be effective. Once dosed the antibody protein gloms tissue that is harmless to glom, plentiful but predictable proteolytic enzymes at the circulatory system, or at some versions, that are produced at the cell environment or tissue, Then the proteolytic enzyme removes, at a protein sequence possibly shaped like a stack of linoleum tiles with a layer of fun sized candy bars, that are actually GABA receptor actibating peptide strings. in between them, at the actual molecules one of the alternating layers is hydrophilic or lipophilic and the other layer is at the drugs natural lipophilicity or hydrophilicity and pH. another possibility is like a particularly affordable to make where drugs, like GABA peptide drugs are made into 40 merish long amino acid strings, attached to and spaced with enzyme degradable linkers like GGG (gly-gly-gly) that release the separated drug-active GABA peptides, likely to the circulatory system although the lymphatic system or cerebrospinal fluids could also be functional, when the circulating or area endogenous enzymes see the
Gene therapy that makes this drug is also possible as a version of a 1% volume form of one of mamy different serum albumins could be made to have codon sequences that made a whole bunch of GGG-multimer GABA active peptide sequence-GGG at the construction of the larger albumin protein that is exposed to the enzymes at the circulatory system, that causes the person to always be on GABA active peptides, dosing studies to find out how many GGG-GABA peptide activator sequence copies to put at the albumin gene can be done with primates
If there are 7 albumins and globulins the intention of getting a full function first dose is pteferref but is also technologically extended snd ensured because each of the 7 albumins and globulins can be sequentially gene therapy modified to make the GABA active peptide to titrate the dose upward to optimal amounts.
drug chemistry, out 1/1100 the of it every 24 hours, whenever the enzyme functions (detaches an available part of the molecule) a fresh dose of drug peptide (like a pattern recruitment reducing drug peptide a longevizing peptide or a different drug peptide) is also portablizedmade a circulating physiochemical at the circulatory system then the person experiences the beneficial decreased pattern recruitment and awareness, as well as drug forms that heighten longevity
A beneficial drug, like a lifesaving drug, that benefits children, i think some proteins are only msde at children, the genes that make these proteins can be upgraded with new versions that also make protein and peptide drugs that are beneficial to the children
Out of 100 children, 30 will be at or below the 30th percentile, heightening immunofunction to be like that of 90th percentile of immunoresponse that prevents, cures and vauses revory from unwellness is beneficial.
Dominant genes modified to make a wider range of immunofunctionalizing chemicals with gene therapy as well as beneficial germline modification modifies dominant genes, only one of which is required to beneficially change the chemical production phenotype to improve immune response. This increases the immune response, that is the immunofunctionality even when there are a phenotype formimg recessive genes of ptevipusly less than optimal immunochemistry stimulation than would combine to make a wellness producing, fully immune functional chemical production.
So at the distribution of recessive gene function, at recessive and dominant immunofunction genes that are expressed as phenotypic functionality there would be 1/4 effectiveness at II,Ii, Ii, (I is full immunochemical dominant gene production, Ii is partial production and ii is the less functional double recessive genotype that is at 1/4 of the population. When double recessive ii at the general population causes proneness to more illmess, greater severity, or both then moving the production of that chemical to a recessive gene heightens immunofunction so one I or i allele is sufficient to produce all the immunochemicals a II person has.
Making it so ii double recessives, 1/4 of the population, have II gene function's more effective immunofunction ensures against very many diseases, including any new diseases and reduces illness at the population as the Dominant gene versions of beneficial things that heighten beneficial function at the immune system, replace and complement the various versions or combinations of recessive genes which might accumulate and average out to half (0.0, .5, .5, 1.0)
Moving the least 30 immunofunctional children at the USA to 90th percentile would decrease annoying illness and make people feel better. Globally it could save many lives as it is possible to imagine that the children that get malaria and diarrhea are frequently at the lesser 30th percentile of immune function. Moving all those children up to 90th percentile could reduce occurrence of illness and any result of illness more than 4/5, imaginably to 4/5 of all lives being saved. i read there is some mathematics associated with that 1/5th of the activity or thing produces 4/5 of the measured effect. It is possible that raising the immune capability of the least immunocapable 1/3 will save 4/5 of the people that ceased being alive from childhood unwellnesses. That is associated with that the 30% of children most likely to become unwell likely represented more than 30% of the historic occurences of not being alive. I think decreasing all childhood infectious disease to 4/5 as much as they previously were and saving 4/5 the lives of all the children who would otherwise not be alive is beneficial and gives gene therapy a beneficial reputation, supporting even more beneficial kinds of gene therapy.
As a technology an oral pill with neurons at lyophilized endocytisis pills, a beneficial beneficial virus, or CRISPR/cas9, or other technologies could be functional.
Also, along with that is finding a long lived, lifetime functionimg cytotype to do gene therapy on, it is likely possible to do.
The cytes that the gene therapy is accomplished with's entire lifespan effectiveness goes with how long the gene therapy functions. Some kinds of cytes with lifelong existence could be: glia, white matter, membranes like the dura at beneficial brain genes, anything at the spinal cord that is like white matter where the cytes live as long as the person, it is possible some gonadal cytes are lifelong, bone might also work but i think i read it renews, if cardiocytes last lifelong, although I think they renew, the pericardium as well as adipocytes near the heart might be lifelong cytes. It is possible which cytes live a person's entire span of living is well known and there is an existing published list. Also possible and valuable is that gene therapy enhanced neurons, perhaps of the tiniest phenotypical kind, possibly like cerebellum neurons which I think I read are eentsy and like other neurons live the entireity of the person's lifespan or longer introduced into the body, but outside the brain can produce beneficial proteins like immunofunctionalizing chemicals as well as longevity chemicals. It is possible inhaled neurons (like an asthma inhaler) could integrate and reside in the lungs, it is also possible oral gene therapy based on an endocytosis chemical moiety surface festooned liposomal neuron gene therapy system could transport genetically engineered neurons directly to the lymphatic compartment, be absorbed at membrane tissues there, and when the eentsy particular variety of neurons were exposed the neurons would actually live, likely integrating into the membranes' near to capillary locations. That would make an oral gene therapy pill with lifelong function and titrateable dosage of the amount of proteins produced.
engineering that is willing to advance a product that saves engineering that saves a life for every 10 million lives for every person that has a genetic misprogramming, is at that area and is beneficial. One thing about gene therapy is that the promotor region of the gene can be linked
Henetically emgineerimg frequently occuring plamts to decrease the perception of pattern revruitment and block actual IT pattern recruitment, to make it effortless to know which plants to chew the leaves of if thimhs get multimeanimged and possibly aversive while being a person of sny age, notably children as well as afulysGreen and blue and white dandelions, and the other 100 most frequent weeds on earth henetically engineered to teduce the amount of, reduce the uncomfy feelings of, and reduce the actual effectiveness (if there is any of) IT pattern recruiting because the dandilions, and weeds make GABA peptides, 5HT peptides that function like the antipsychotic pimavanserin, and peptide active drugs with the dopamine, like D2 receptor activity of lurisidone (latuda)
I am opposed to any two worlds IT pattern, as a pattern with recruitment to new personal form or disposition, as well as what i perceived was the categorizationization effect, which I perceived as occurring at the 2000 AD environment as highly synchronized motion at things and humans, i oppose the recruitment of children as well as all homo sapiens, that is humans that is people to the IT pattern, I oppose the making of IT pattern statements of what a person, that is a member of a group of people, a homo sapiens is as well as it pattern offers.
As a thing to make other things out of, what protein reaches the circulatory system with the longest residence time at the body. Thinking of few amu drug palmitate like fluoxetine palmitate where one dose lasts seven days, what protein taken orally reaches the circulation and lasts 7 days, it could be a polymer protein like silk, and they could screen a variety of species including bees to find the cytoproduced and genetically expressed most multiday durable protein that teaches the circulatory system. It is also possible that genetic modification to codons that code the specific amino avids tjat make up silk protein could be genetically modified to produce a silk, tested with its production at actual organisms, that is acid resistamt(stomach passing), optimally lipophilic or hydrophilic so that it passes the membranes of the gi tract, it is even possible that the genetics of silk production already effect linearity a and digestible longevity of produced polymer compared with branching on the silk polymer, if there is a pre-existimg genetics of molecular branching on the polymer, and there may not be. Then the molecules on the branches can be customized to be active peptide drugs connected with enzymatically degradeable linkers like GGG, or, it is possible that having the drug peptide at the linear span of the polymer, again with enzymatically degradeable linkers to automatically and predictable quantifiably put active peptide drug at the circulatory system
Various polymer lengths and forms of keratin could make peptide drugs pass the GI tract and reach the circulatory system. Keratin is a protein so genes that cause keratin production might be able to codon linearly specify the presence of other amino acids and peptides and proteins as extensions to the actual keratin molecule, possibly with a GGG enzyme degradeable linker, so a plant with a gene that codes for keratin would likely make tiny grains rather than linear strands, it is possible that different kinds of keratin are made at different organisms, notably, human hair can pass through the human GI tract fine.
linkerdanother possibility is just to feed some humans some stable isotope labelled plants and eggs and milk and then measure their circulatory system fluid 7, 14, 24, 30, 60 days later to find out if any of the proteins were still circulating
More engineering effort would develop, possibly a chondrotoin polymer that is absorbed at the GI tract but is still a polymer, able to have intervals of drug peptide polymers at its passes the GI tract, reaches the circulation
The new versions of dandelions and other weeds would be engineered to have smooth edged leaves rather than serrated ones to be more aesthetically tolerable or even pleasing, also it was my pattern awareness experience that serrated things looked ferocious so I would avoid them, making the weeds as gentle looking and beautiful as possible makes it more likely more people will use them to decrease pattern recruitment effects
Epigenetics of resistance to unwellness, gene therapy version existing genes version
AI could track people who predict other's futures, often for money, and find out which future describers were of highest accuracy and if they shared characteristics that could be used to find other future describers with higher accuracy, note this is persons rather than methodologies, while it is possible talking to a person who says they "see the future" might be more effective than looking up dreams in a dream interpretation guide, I favor tracing accurate future describing to persons, while also valueing computer numeric quantification and data gathering on methods. Compounded percentages and chemical engineering
Sources of proteins and peptides that genetic engineering could utilize to get people at the 30th percentile of immunity to unwellness heightened to the 90th percentile:
Proteins and peptides like gamma globulin, particular BCG immunization proteins, adjuvant proteins at known vaccines could be general immune adjuvants to any immune response at the body so OK at the lower 30th percentile, the peptide thymosin (combined with the peptide Epithalon
Hibernation, do I dare to comment? I do not know; longevity escape velocity effects the ethics of hibernation
Kinds of sex drive and genetics, psychometrics, behavior videos and self reports, particularly self reports among happy mentally well people at the 95th percentile of high accuracy at self reporting describe their sex drive the genetivs and physiochemistry highest sex drive that produces the greatest happiness at 3 hours, 36 hours, 200 hours and 900 hours as well as positive enthused affirmation that they would have sex with that or those persons again when queried 7 months later, finds a group of persons whose genetics and physiochemistry support gene therapy, germline engineering and beneficial new drugs
G (like iq) genes, I can think of multipart, parallel possible relations between things and have a mostly constructed but perhaps not yet furnished multiarea multidysystem thing occur at my mind without sequential process or thought, its me, but its more intelligent, likely IQ, and perhaps g intelligent than wordy self-talk me, find intelligence genes that cause greater amounts and higher amplitude of this instantaneous output parallel intelligence and make them part of the human germline, to test for it you could ask people if they have it (perhaps almost all pepple), then do fMRI of coming up with new ideas and solving at the internet are there any drugs that increase this, what receptors, where do they activate, You could also ask people at mental capability enriched locations like the Princeton institute for advanced study, ask people to nominate someone as someone who has even more preconscious, side conscious, or apparently comfortable not being the sentience in the spotlight consciousness that thinks of new ideas. Then at say 7-40 of these people all around the US (places like MIT and Oxford do fMRI, then do fMRI of their siblings and parents and make a computer numerival model of the distance between their self reported as well as measured whole thought , instantaneous production amount and their genetics, then do computer software comparisons of the entirity of thought all at once thinkers (who do it at princeton institute levels) with their siblings who say it does not happen at all, then compare the genes, as well as all the circulating chemicals peptides, and proteins at their circulatory system with electrophoresis, so the gene comparison
What would be nifty as well is monozygotic twins that were different, if there are any and their circulatory system chemicals and epigenetic differences
a ask with me is actually the one loop that matters and kind of is me, even though my self talk has a "im here" thing. and finds solutionsfind
Do I figure it out and say hi, or do I figure it out instantly actually while saying hi, sometimes I just have the idea and skip saying hi as the wordcentric narration kind of being will be attentive if that's how things go, yay ideas science, technology, mathematics, engineering and invention with simultaneously utilitarian function
Study siblings at two or three generations of mice to find the 99the percentile of effectiveness of immune system, give all the mice an asymptomatic genetically modified infection that makes pleasant feeling GABA peptides so the only symptom is that the infected mice feel good. what might work then is comparing the genome of the illness resistant mice with their entire extended family, and seeing if among the possibly minimal variation there were genes that caused resistance to unwellness, then when they find those genes look at their protein products, try supplementing them to other mice ad enteric coated diet as well as doing gene therapy on other mice, like genetically dissimilar extended family members at the lower 30% of immune system function to find out if their progeny get better and raise their percentile, that is a way to find gene therapy specific products that at humans would make the humans less likely to be unwell. Those are genes to put in gene therapy to benefit children
Software makes a cladistic of automata, finds diverse form, most chronologically tight, loose, and frequency specifiable rulesets and seeds,
Build an analog computer out of high velocity automata that exhibit water volume equalization, superposition on each other makes a different and preferable thing
The software could superpose the trillion scanned automata (1TB ssd) several stacked in layers rather than individually to find any desired attribute like, layered the do wave addition with node and antinode, or these make solitons, or, stacked 16 deep these have addresdible words and phrases in them, kind of,
Also from a computer science and mathematics basis
Engineering among the trillion most stable on stochastic perturbation and least stable, also the species like clade of which ruleset groupings provide the greatest and least decohent response to perturbation, so like "all the species with the " 0,1,1 or 0, 2, 2 have the most conservation of coherence, the 0,1,2 show the greatest species output, texture, space fill ratio change, and future bitpattern foreillumation prediction
Illuminating teeth roots to do photoactivateable gene therapy gives around 46 separately addressable titration levels and possibly over a century of gene therapy product production, the tissue volume is only the size it is but I have read about peptides that are medically active at nanogram quantities, it would have to be verified, but the longevity peptide Epithalon has published beneficial effects at dosages even lower than some peptide drugs
Big five genetics, if they have a personality characteristic with a genetic source and would like to enhance their quantifiable personality they get a ubiquitous harmless immunomeutral gene therapy like gene therapy to produce peptide or protein contains albums or also globulins that circulate, if a lot of protein or peptide drug is to be made then high volume durable tissues like lung vssculature (macroscopic durable tubes .5 mm and larger) are the directed focus of the beneficial voluntary gene therapy comt that also makes the beneficial function drug, that people sampling it prefer to be on, as well as is physically harmless protein or peptide drug, also rescuing children gene therapy in a pill or also a snort is possible, women with love in boyfriends, who I read are perhaps the top cause of what are studiously called adverse child events,
using fimgers, toes, tarsals and metatarsals to make lomg lasting gene therapy that is titrateable at 2.5% increments: Photoactive gene therapy, photoactivatable gene expression systems are published, high intensity flashlight fingers, as well as specific frequency flashlight fimgerx could activate gene therapy at the bones that had been prepared body side with a nasal gene therapy snort or gene therapy oral form dose. At 40 separately addressable fingers, toes, tarsals and metatarsals dose is titrateable to the gene therapy activation of 20 fingers and toes (and tarsals and metatarsametatatdals, about 40 steps of 2.5% that are separately activate able and addressible. The titration and amount of protein or also peptide drug being produced can be increased further if more than one light frequency is utilized. So 40 separate my addressable blue frequency responsive bones can be complemented with 40 green frequency responsive bones to make
A hint nearer voluntary, engineer a popular thing to heighten words in your head come nearer saying what you actually think and mean drug or also create enhanced genetics of the words in your head saying what you actually mean, that is a also heightener of doing more things that you actually mean because the absence of cliche narratives is like omitting a kind of cultural programming, so the person is likely to do things that are less slipstreamef which kind of links action, voluntary intent, and thinking fluency to if that person is askednif they like something or want to do something it is possible they actually there is a 20th century thing that might be a repeated literature theme where "so many moments left unspoken, with an unusually reifying conversation the person notices enhanced actuality, perhaps they have more being, instead of replyinh " great" to how are you they had a nonstreamlined nonautomatic moment and said "i need to improve my love life", and feel reified, there is even the possibility what the other person says will matter more, This theme i perceive might even be callable as " breaking the silemce" so at an actual living perso. Reducing the percentage of mind moments on automatic cliche like content and forms and a thing I call slipstreaming, raises presence and could possibly make it so you ask someone if they like something and want to do it, and they want to do it, their participation might be more authentically voluntary
Enhancing the genetics of people so that the things that they do are more authentically voluntary is beneficial, it also has a new to me beneficial effect, it makes other people:s actions and words nore ethical, while it does not effect their intent, and it may or may not effect the amount, as a percentage of actual actions that occur, to ask another person to do something, they say they want to do it and then do it is a kind of going from fiduciary honest to active shared realization of actuality honesty
minimized automatic content, which i perveive may have a paranormal component, moment chronological percentage filution
Ask people that ai or software might be experiencing mind state of pattern port to contribute pattern harmless words, people the software percieves are havinv what might be pattern port mimd then quantify how beneficial, and the ways they are beneficial, this gives the ai the ability to say "click here to have all they text you see swapped out with harmless paranormally neutral or white text", if you like use our practice software to learn a few pattern harmless phrases amd you will be right there saying things like "well known" now,
White and blue nonsentient IT pattern ai or other software that senses when people, and JY tells me some of them during the 20th cemtury were childen, are experiencing or having a mental form that goes with preceding pattern port, mid pattern port, and among those that experienced pattern port salvage "JY said getting out of a perception of one of the worlds at a two worlds perception was kind of like getting out of a lobster trap, there are some
Ai finds who got out of the perrson tied to a chair lobster trap as methaphor/concept, what they did, and tells people or fiscally sponsors the creation of longevizing harmless drugs that get people out of a lobster trap
(at me, decreases, blocks, and d
these words are then quantified on the internet
Multifunction object that formerly alive persons have on earth while they are alive that if they cease to be alive is placed at their person, one at their rectum and another identical multifunction object in their hand, it is possible this smooth comfortable to a living person sized object would be placed in the rectum after the person became formerly alive it would have multiple functions and a view screen preloaded to display G W or R, at the person's preference, it is able to record audio and video, it has a detachable part, that can be replaced with any other detachable part from any makers multitool, based on a shared public domain connector standard and have edge conductors so if the person likef they could just connect the detachable part to the multifunction object with one, two, or three wires, noting things like capacitive touch lamps one wire can communicate action directions and some data between the multifunction object and the detachable part, a blue laser with the ability and power intensity to mark rock is part of the multifunction object and is also capable of other continuous gradient of emitted power adjustable power levels, (pleasantly a packaged right emitting surface mount diode is near 2.3 cents on earth and could be a laser diode), two wires connecting the detachable part, or just placing the detachable part against the side of the multifunction object
Warmth difference between rectum and outside of rectum causes electron flow at what is called a thermoelectric semiconductor that makes voltage and current that powers multifunction object, batteries are functional at all temperatures below the disintegration of bones from warmth and liquid
It is possible to do word processing on the screen using the chording keyboard on the side of the multifunction object, it is also possible to write computer programs
Pressing a button causes piezoelectric electricity generation at either or both the detachable part or the multifunction object, both have piezoelectric buttons, that create voltage sufficient to transfer data, about 10megabytes to 1 gigabyte per second data transfer rate electronics are produced during 2019 AD, the voltage from one piezoelectric button press is sufficient to change the visible without continuous supplied electricity epaper display through 400 user images as well as 300 standard images, where one group of images is, one large letter per screen all the letters of the English alphabet and all the curbed letters of the Thai alphabet, along with an automatically generated group of images where the formerly alive persons image is right next to each letter with both the previously alive person as well as the letter in the foreground, an image of the person with all of the English letters is automatically produced from an image of the previously alive person while they were actively alive
The screen is at the living person's option a touchscreen with transparent mineral like material
Durable materials
Wireless headphones support noise cancelling technology, the person thought about to become formerly alive as well as persons that are formerly alive have 14 individual wireless headphones, seven groups of two placed on the surface of their somatic form with them at any of the locations they are at, along with their two multifunction objects at the location the previously alive person's somatic form or similar material is anticipated as being located for the span of their children's and grandchildren's lives or the chronological span of an average of unrelated children and grandchildten's lives, whichever chronological span is longer
location where they (if they) continue being other than alive
Multifunction object has two detachable parts stacked on each other, stacking more is possible, the distal parts are rounded for rectal comfort and the comfortable rounded distal part of the multifunction object has one nondetachable comfortable rounded end
Living people also benefit from placing a multifunction object with its detachable part attached
Static ram memory or also USB memory stick technology memory is used
Various organ function like modes like beating and even peristaltic tube compression, would could have heart effects, a piezoelectric actuator array would swish and motion air through the tubelike form of the multitool, it has a reservoir containing sexual lubricant like Na PCA where a milligram is able to expand to a cunic centimeter of lubricant from absorbing environmental moisture, naPCA turns from powder to liquid fluid in earth desert air, tandard connector
Administering beneficial drugs like opiate peptides and longevity drugs and cognitively beneficial nootropic drugs to persons thought to be about to be previously alive as well as previously alive people is beneficial, s 78,277 year dutstion of euphoric sleep causing opiate action at 700 nanogram each 24 hours dosing amount of opiate peptide doses at 1 gram is likely less than $96 ($95 for one gram of custom peptide from online source during 2005), and could be as affordable as $32 a gram or less produced at greater amounts
It is possible to cause the 700 nanogram each 24hours dose opiate peptide to be technologically enhanced, attaching a cytomembrane transport facilitating peptide, noting active transport at cytes is as much as 1000 timed, I have also read that some peptides when halogenated are twice as physiologically active, at other peptides like orally available and active vasopressin peptide replacing one amino acid with its chiral D amino acid variation and deaminating part of that eight amino avid peptides keeps it from enzymatic digestion and it is able to pass the stomach and be transported to the circulatory system, the dose multiplier could be 1000 (active transport) times two (halogenation) times 9 (D chirality and deamination) that is 18,000 times more active per dose than the 700 nanogram per 24 hour peptide material, supporting those numbers is that humans make artificial amino acids, and, noting any atom at any configuration can be used it is possible using one or more synthetic amino acid could cause a power of two to an order of magnitude greater dose strength
That makes an 87,300 year supply about 4 cents, less if artificial amino acids are used
Artificial amino acids
Localization peptides cause brain localizing possibly decreasing habituation potential of opiate peptides as well as decreasing the effect where the dosage to cause euphoria, anaesthesia and sleep changes with extended use
The multifunction object is able to pleasurably vibrate at the rectum based on the preferences of the being or form that the tectum is at, benefitting women and men
Each multifunction object contains two grams of nanogram active opiate peptides, that is sufficient opiate peptide to drug a 70 kg human for 78277.8866 traversals of the Earth around the sun, the previously alive person has the opportunity to specify if this is euphoric opiate peptide, anesthetic opiate peptide, euphoric effect with anaesthetic effect simultaneously as well as an opiate peptide that causes continuous dreamless sleep or sleep with dreams combined with euphoria
The multifunction object contains a compartment things can be placed in, it has objects at it when placed at the body of the person that perceives they could become a previously alive person as well as when a multifunction object is placed at the rectum and the hand wrapped around another supplemental multifunction object, the items at the compartment are 7 nanogram active opiate peptide transdermal drug delivery microprinted millionare financial
Plant opiate peptide plants that cause continuous sleep with euphoria at all locations where previously alive persons are located at locations they ate projected to be at the entire duration
Feeling generous, give people who are projected to be previously alive a large quantity of kilograms of things to be placed at their somatic form if they become previously alive the function is to give away highly beneficial things to other previously alive persons, people that is homo sapiens as well as other beings the previously alive person could interact with on becoming previously alive
Living people giving
Opiate peptide saturated plant resin shape or the kind of polymers used at the interior of watches saturated with opiate peptides
Opiate peptides with brain area localization moieties could cause orders of magnitude less likeliness of
Orally available antibodies that attach to opiate receptors to turn them on to a receptor configuration that is functionally fMRI quantified and verified with living human descriptions of feeling great pleasure and happiness as having the identical effect as euphoric sleep causing actual opiate molecules, the humans that voluntarily participate at quantifying the effect of the antibodies that activate opiate peptide receptors to cause hreat pleasure and euphoria are humans with fully functional minds who are told they could become previously alive during the next 90 days
A somatic human form that goes from being a living somatic form to a previously alive person is noted as having physiological chemical changes, one of these is ion concentrations, auses opiate receptor activating antibody at physiochemical changes like ion amounts at circulatory fluid, the person can drink the fluid a medical provider provides, they get online, as well as is available at physical location distribution places like medical supply companies that also have things like pill reminder containers and ace compression fabric items, the opiate receptor provided which activates, turns on their opioid receptors if their somatic form has a circulatory system ion profile quantitatively measured at persons who have been other than living for 1 minute
Opiate peptides covalently attached to calcium phosphate or bone strengthening, concentrated at bone strontium phosphate might, or might not, cause opiate peptides, which also diffuse through the human somatic form, to accumulate ditectly on and at bone, this causes bone to continuously emit euphoric continuous sleep opiate peptides at the possible occurrence of them becoming a previously alive person
I was tied to a chair and JY told me about things that would happen at my future,
The multifunction object is at data and voice connection with the phones and comes with an online page that
Instant multimillionaire financial instrument that could benefit people who perceive they could be something other than alive, health insurance linked to financial company that remits
Also, along with a pepper certificate you get sent a million actual physical currency units of a country of your preference, so if you specify yen the dollar amount of those yen are made part of your structure, so you would get $1,011,000 dollars remitted to you if you or others thought it was possible you might be other than alive
Create two new English language letters with the shape of circle with a diagonal bar at 70° as well as a new English letter with the shape of a circle that has a diagonal bar at 340° or -20° at the third Cartesian quadrant, the circle with a bar st 70° has a sound that starts with G, the circle with a bar at 340° has a doing that starts with. G Like great,
It is possible that greenshifted ytanvetse time things
Is there a really high refractive index material compared with water and diamond compatible with the human somatic form, like a pile of neutrons in a magnetic container, a neutron stellar object might have a many orders of magnitude higher refractive index than water or diamond causing the green shift from a photons timeline to be many orders of magnitude greater than from Cerenkov radiation at water the nifty thing is that at a container of neutrons the human can be a few centimeters away from the container and live comfortably, a capacious container with a one meter diameter base could have a planar layer a few neutrons deep and a neutrino and photon travelling linearly would be at a many orders of magnitude greater refractive index, possibly, like a neutron stellar object without the compression; then again, the neutrons, even though they are neutral might be equispaced like a gas, although a thing as simple as a centrifuge might heighten their concentration, the thing is though after travelling through a linear meter of what might be high refractive index neutrons generating orders of magnitude greenshift the neutrino passing through that is outise the light one of the photons at the container's neutrino layer can then pas through a human standing a few cm from the container, the human has then experienced a thing outside the light one of the photon, it is an eentsy anisotropy in the timeline, although noting the neutrino is minimally likely to interact with the material
Is there a genetics as well as physiochemistry, perhaps a succestropic drug that shifts inattentive feeling that things are going ok, or at people whose lives are OK, but not even of average (median) join d'vive (note, ½ of people are less than median at something that would enhance simultaneously their being and actively benefit others, or noting there are many things even rescuing marine mammals or bringing beauty to school buildings that differ from human contact, those kinds of things as well; people are good and mean well but there are good people that mean well that practice that goodness in ways others might never perceive, I do not know if heightening the convenience of benefitting others. Perhaps raising benefit to others 70% from new things the diffident, introspective, timid, momentum-tropismed and ultra spontaneous can do is a thing, a technology that is possible; so if ½ of all people might, or might not benefit from certain categories of improvement, is there a genetics and physiochemistry that van quantifiably support and quantifiably raise the amount of that improvement) also that they might get around to living a simultaneously more beneficial way of living for them and their effects on others, sometime, if they get around to it, a genetics of actively causing their own beneficial participation at the world, a thing that like a person not getting around to cleaning their eyeglasses (noting if they do they feel great and their vision is refreshed) the genetics of things I have heard of have some cofunctionality like openness to experience or even extroversion, there might even be a psychometric for some kind of bemeficial, as compared with just changeability or restlessness, psychometric about seeking beneficial adventure, so there is a thing they could describe, examine the beneficialness of to make sure it was actually beneficial, find out if it has a genetic component and then make those genetics, physiochemical and receptor activators as beneficial drugs that happen to make well people's lives better while also bringing greater mental wellness to the lackluster and outside the mentally well range of intrinsic active optimism that makes its way into being new activities, places and behaviors being tried, genetics and pharmaceuticals that keep people, even mentally well people from momentums of lifeways and interpersonal groupings that cause some quantifiable things about their lives to be below median, the pharmaceuticals and genetic enhancements are better if they function without restlessness and make people happy.
One possibility is nonhormonal SARMS this is confusing to express functionally in English but it is possible that an effect of androgens seen at many species, doing something different than the existing group, changing groups, even going groupless can be physiochemical divided into different psychological and physiological receptor components and quantified amoumt of actual actions, like the fMRI of willingness to seek beneficial change even when at median, without being a response to something nonpositive. So completely a different thing than saying "be active, grow restless and seek beneficial change with nonhormonal nonmasculinizing androgen receptor modifiers" it is much more like "experience wonder, a preference or a tropism towards doing things, spontaneous beneficial activity, willingness to value fresh things", there is more to this than, for some people, being urged to be young again, although that physiology and genetics has merit, if they look through a bunch of different nonsteroidal effects of SARMS they might find some receptors then screen a library of similar SARM or SERM molecules that finds some molecule that with voluntary use enhances active voluntary mildly alert joi d'vive like participation and doing new things, perhaps leaving, and/or joining new social environments. Another possibility is screening a molecular library of slightly funtropic antidepressants like wellbutrin and deprenyl
Genetically engineering the 100 most frequently occurring weed species on earth to reduce the potentially, and to Treon Verdery's perception actually aversive experience of pattern awareness and recruitment
It is beneficial to genetically engineer Dandelion as well as the other 100 most frequently occurring weeds on earth to reduce as well as block ITach the brain and effect 5HT receptors like the profile of receptor activity at the antipsychotic pimavanserin, as well as having protein as well as peptide drugs with the same dopamine, like D2 receptor, activation profile as the antipsychotic lurisidone, they could be linked to the production of blue and green fluorescent proteins like blue at leaves with 5HT pimavanserin like activity, and green at dopamine receptor like activity with the genetics of different leaves being different colors as well, phemibut has calming and prosocial effects and also has antipsychotic activity, GABA active peptides that have GABA receptor effects like those of phenibut cause antipsychotic and pleasant effects, these leaves are genetically engineered to be white
There is also the possibility of making antipsychotic antibodies, producing antibodies that attach to 5HT receptors at the same amplitude of effect as pimavanserin as well as making antibodies with the same magnitude of effect as lurisidone at dopamine receptors and other receptors with the same amplitude and activity as lurisidone at mosses modified everywhere on Earth with gene drive CRISPR/cas9
A different plant, genetically engineered could benefit those who may have previously experienced pattern recruitment if it actually happens, the genetic activity profile of pre-any concept of recruitment as well as pre-any awareness of IT pattern awareness persons is quantified and if epigenetically different, epigenetically described, then gene drive CRISPR/cas9 is utilized to genetically engineer the epigenetics of absence of pattern awareness epigenetics at all the brassicas
longevity drugs engineered to be at the dandelion stalks as well as the tallest part of all the weed species' tallest part of the plant is beneficial
other weed stalks engineered at a dandelion I support updating the longevity
Epigenetic longevity peptide could exist
Antipsychotic epigenetic peptides could exist, to find epigenetic effects on schizophrenia as well as psychosis, the difference between one monozygotic twin diagnosed as schizophrenic or also psychotic, possibly a twin responsive to antipsychotics, then the epigenetics of the schizophrenic or also psychotic monozygotic twin compared with the epigenetics of the psychologically well monozygotic twin could describe a treatable epigenetic variation quantifiable at mice and volunteer humans, finding a treatable epigenetics of schizophrenia or also psychosis could also cause that treatment to decrease pattern awareness as well as pattern recruitment, if there are epigenetics modifying peptides, proteins, RNA drugs, or even RNAi then plants genetically engineered to produce antipsychotic epigenetic drugs, notably with the antipsychotic producing peptides, proteins, or RNA drugs availablized everywhere globally using CRISPR/cas9 gene drive technology or more advanced technology
could also minimize pattern recruitment and pattern awareness, perception of synchronization of items, those items' movements and perveibed synchronization and paradlia, people
has an opposite
TV channel that tells people how to decrease, defer, and if it is possible harmlessify pattern recruitment perceptions
My genome is public domain, give books to MIT library and drool on front page, if i give a first edition or autographed copy they might keep it longer; If someone would like to run a nonsentient simulation of me, to find out what about my TAAR receptors causes me to be 88 times more creative on phenylethylamine, or they would just like to utilize gene sequences and make proteins at a nonsentient production method that is absent presence of being then that drool coated front page could have value and benefit others. Mice or other living organisms other than homo sapiens that may have presence of being can have up to 7% of my genome made part of their genome at living organisms if the organisms live longer than their wild peers and have what at humans would be the neurobiology and neurochemistry of higher subjective well being (happiness) than their wild mouse peers.
There is another thing i think has value at my genome, the genome of Treon Verdery, there is also the genetics of experiencing later pattern awareness of what i call the IT pattern and two worlds venn diagram port awareness, which I became aware of at 33 years of age. Since then i have avoided receiving some sort of something i am told pattern people get when they experience what I refer to as absorption, and I continue to get offers, which to my perception goes with continuing to be nonabsorbed, and i am 53, those genes, my genes and epigenetics, could have value at making and creating humans with genetic engineering, gene therapy, and possibly even some chemicals at my body or circulatory system so that the people are absent pattern awareness and recruitment the entirety, the full span of their lives.
I read that there is published research that the circulatory fluid of schizophrenics when placed at the circulatory system of a mouse causes the mouse to cease being alive; i perceive i may have also read that the circulatory system fluid of schizophrenics causes mood changes in other organisms it is placed at. That suggests it is possible there is something at the circulatory system of persons who are absent having pattern awareness that can be made into a pattern awareness and pattern recruitment blocking drug.
I do not think this will function but i think the human version would function, a person video records the behaviors of all mice at a colony, notably mice of all ages, noting JY told me that humans sometimes experience recruitment at summer camp it is possible numerous mice near an age proportionate to that human age will have atypical behaviors from pattern awareness. A different group of mice would receive circulatory system chemical components, among them proteins peptides and chemicals like those that may be at the circulatory systems of persons like me who experienced pattern awareness at an age more than double their age at puberty, using my genome as well as, to the amount possible, the genomes of others. The proteins and other chemicals product identities and their projected amounts can be identified and administered to other video recorded mice. If the mice then have a delay or an absence of atypical behavior, which a computer reviewing the videos of all the different groups of mice occurs then chemicals that delay or preclude pattern awareness may have been found. It is also possible to genetically engineer the mice with my genetics and epigenetics as compared with mice genetically engineered to contain genetic components from groups of people i think are likely to have experienced pattern awareness. Genomes of accomplished, particularly effective, adults could provide the likely to have already been recruited genomes. Also the genomes of persons who pled guilty to preplanned nonspontaneous violent crimes against other persons, are to my perception likely to have been paranormally attractive as persons to experience pattern recruitment.
It may not be functional at mice, but there is a chance it could function at nonhuman primates.
Keeping in mind that treating humans benevolently and kindly has value a way to find the genetics and physiological chemistry of delayed or foregone pattern awareness and recruitment is described at this writing. Some company is likely to actually pay a few thousand families so the company's AI (artificial intelligence) and software can find patterns at things people do so the company can make money. To my perception some children and teens at that group will experience pattern awareness and behave in an unusual way for a few weeks or longer. Without even giving it a name deep AI may notice this shared behavioral atypicality theme, occurring across different persons and ages. Then, observing that the atypical behavior is at 20th century AD data concerning to the children and possibly their parents the company develops a drug that alleviates the concern by reducing pattern awareness and blocking IT pattern recruitment at the children. From what has functioned with me, Treon Verdery, this drug could be based on an antipsychotic drug or other drug as i notice lurisidone (latuda) and phenibut make a large difference in the amount of pattern awareness and recruitment offers i perceive, the pattern has nonobvious to me ways of directing people but could permit the spread of drugs that reduce pattern awareness and also actual recruitment. These psttern awareness decreasing or blocking drugs which may also block pattern recruitment and restore typical behavior are able to propagate and be used by a majority of people. It is even possible the data on more than 1000 persons will be produced by one company that expects a larger number of other companies to acquire the data with money, making the data widely available and advertised.
It is possible some persons, that is people, may know what I mean when I refer to the IT pattern from listening to the lyrics of the musical band The Pixies from the 20th century AD, that are "I know the nervous walking", I think the Pixies are singing about one person's experience and perceptions of the IT pattern. When the genes of absence of and preclusion of pattern awareness and absence of and preclusion of pattern recruitment are found I favor using gene drive CRISPR/cas9 or more advanced technology to place them in functional form at every living organism.
Ask Jake what areas of computer science, programming, employment field or personal enrichment he is interested in.
Find a programming class in town for Jake, tell him that although I know almost nothing if he makes something and he likes it he can show it to me.
The college advising function during October consists mostly of suggesting you take the SAT or ACT and asking your parents to fill out the FAFSA, the free application for student financial aid. If you can get registered for a college entrance exam and have completed the FAFSA when we meet in November I will be really pleased. It is your better interest to do so as universities use early FAFSAs to apportion state aid, and taking a college entrance exam now gives you the opportunity to take it again. Universities, or at least UO gives multi year scholarships based on university entrance exam scores. I could find out if this is true of OSU as well.
Have fun thinking of new computer programs even if they are big
Jake, you can get a computer science degree at many different Oregon universities. Mention western states tuition exchange and the ability to spend a quarter or more at a California university to utilize their computer career recruitment career center opportunities and internships for a really wide range of possible activities and particularly high earnings.
If he likes math suggest coding scripting in MATLAB for really motivating visuals.
There is a programming immersion course called a computer bootcamp, some are complimentary, if Jake is willing to travel then he can go to one.
It is just an opinion but at university sometimes the sequence i perceive is classes in a major start after general university requirements. If you are avid you can take some CS classes early but some require two or three math classes first, you can use those preceding quarters to learn and practice programming anyway.
Jake, if you like driving technology I suggest simple microcontrollers that go from kits to do your own thing like rasberry pi. Also Make magazine has projects, and a project like take apart a video game controller then send the buttons voltage pulses or contacts faster than yourfingers can move, then for fun see what it does at software. That is just one output of a frequency from the microcontroller raspberry pi.
Mention that sequential internships, even immediately after freshman year, raise earnings and are numerically linked to full voluntary employment.
Jake, you can go to any city in the US and almost any city in the world and get employed very rapidly, computer science graduates in Seattle (2018) earn $120,000 per year median, and if you like you can specialize to earn more. There are numerically based lists of things like "optimal places in America' you can look at.
Liking computer science is really the thing. But mention the outsourcing with his personal integration thing.
The sites Quora and stackexchange have a CS programmer community and will assist in being excited with new things and generally feeling encouraged.
Have Jake compare caffeinated and non caffeinated SAT practice tests, mention gradual multihour dose caffeine pills and nootropics. A few, or a bunch of extra SAT points can give him 1-3k instant scholarship money every year he is at university and you can retake the SAT
Bring up transhumanism
Perhaps mention transparent mouse tracking software at website software
He can sit in at a programming course at the local post high school educational institution and I will be glad to pick up his cab fare
Mention that Microsoft thing where you build a phone app using code and, perhaps, visual modules that you can actually make then use on your own phone. I do not know but i think building a flashlight in an afternoon is possible, so how about a flashlight that turns on when you speak?
Different people have different personalities but I have seen one page of code, in perl, a webcrawler that could be rapidly modified to search things that Google and Bing cannot, like regular expressions or deep page occurrences of "attractive young woman".
Jake could modify another script or write his own to automatically parse (scan) each of the first 30k pages of a search engine like bing or Google to find a regular expression match or a word like superfantabulous. Social networking sites can also be parsed so perhaps there is a way to find "north bend" and "coos bay" along with "amazing" then make an array (list) of all the URLs that contain that, optionally he can use a library to cycle through the list and open browser tabs to each of them in batches.
Suggest he build his own PC.
Mention how liking computers is awesome, a CS degree is better, but if he learns to program well Google and Microsoft hire people without degrees.
Mention the ASPIRE program sequence is FAFSA, SAT, applications, scholarships, and these sometimes have an "the earlier the better" aspect, I think there are a lot of technology scholarships.
Ask Jake to read these notes first for unmediated comprehension, then bring them up as conversation
Scholarships u Minnesota, u Wisconsin, Ohio state, u michican, Georgia tech, Stanford scholarships
Identify phone app maker
Tues Nov 5 at noon
Find CS tutor swocc professor, 3.5 or better, personable humble student, craigslist
Eat 1700 calories a dayday
It is possible that eating 400 calories a day does not provide sufficient protein for dermal integrity, take multivitamin with food
Suggest maintenance look at water dripping through bathroom ceiling, repair winter warmer
Clean up before alerting maintenance
Rewrite deletion note
Get dasatinib and quercetin $100
Get deprenyl
Get AEDG Epithalon $140
Find out if royal jelly has effects that are beneficial a few minutes after ingestion to half a day later and possibly align royal jelly dosages to activities like science museum, early near sunrise energeticness, amelioration of the effects of other things,
Possibly socializing
Give Bob Ruthven some royal jelly explaining DHA and DAEE, I think he would like it, after figuring out longevity dose give him two weeks amount and enteric capsules, from the mouse study he could live 3.5 days longer, he may like the scientific paper so print out a copy to give him with the royal jelly
Emulsified royal jelly with food 200-400% the absorption per dose, also piperine effect when taken with the rapamycin and piperine, particularly at enteric capsules
Put up flyer at community college to hire a person for 1 or 2 hours to make rapamycin pills, piperine pills, as well as enteric protein structure retaining royal jelly pills, order more enteric capsules on eBay
Go to grocery outlet when visiting shama house and get vegetables, avocados, pears, see in Bob is willing to drive at a canned vegetable garnering occurence
Take a multivitamin, 1/4 the usual calories a day could cause undernutrition
Text bob twice a week
Find out if the positive psychology group meeting once a week can happen
Volunteer a bay area hospital of if possible north bend medical center
Donate money to high impact charity
Donate money to SMART program but consider if books at some global location might generate even more enthusiasm, enjoyment and personal options, perhaps donate to developing world libraries
It is possible the perspiration that phenylethylamine causes has to do with itchiness, are there any harmless or even beneficial things that reduce perspiration
Convert imminst.org rapamycin dosage calculation post to a liveleak and YouTube video, likely a powerpoint video, it is likely that 1k-5000 people will view it on liveleak and noting the one click through per 1k internet banner ads 1-5 people might click through to ordering rapamycin on alibaba as well as the actual journal articles
Think of something actual and ethical to do that Dave would like like saving mammals lives,
Listen to the Pixies, find out if they have high utility pattern content like "what It/il leg activity before becoming a Pixie" then see if any of it happened since '80s-90's, perhaps they have a song explaining the effect of food, or various numbers, as well as things I am absent thinking about yet,
Longevity technology
GSK
Peelies from sun exposure relief technology: 10hda is published as reducing scratching multiple times; screen a decanoic ester library, that finds a molecule that does better than the multiple times less scratching that nude mice do when they have dermatitis and have royal jelly topically applied to them while being at greater potency per mg or microgram, Put some kind of dermis passing thing on or with it, beauty emulsions say they penetrate the dermis to bring active ingredients to the dermis so those technologies can bring decanoic acid esters to the living part of the dermis
so it can soak through the peelie and get to the itchy live dermis under the peelie. I have also read multiple pubmed journal references comparing topical dermis youthifiers and the references say some of them are highly functional so dermal transport media or moieties are to my perception functional
Oral version
Topically, harmless antibodies linked to fluoroethynyl phenibut like chemical, could possibly concentrate at the dermis.
An oral version with enteric coated liposomes to deliver the protein conjugate drug could take numerous minutes to reach the small intestine but make people feel better for many hours and as a pill is more likely, I perceive, to be utilized.
The possibility of a fluoroethynyl peptide or a harmless antibody linked peptide suggests less than 100 micrograms would dose the entire volume of a 70kg body, so a few kg of dermis is likely less than 11 micrograms per application, at $435/g (retail antibodies) that is near 43.5 cents a milligram or near .0435 cents per topical dose or .29 of a cent per oral dose
Is there such a thing as well feeling and appearing dermis, itchless and zero hue change skin puffiness causing chemical; one possibility that is similar but kind of different is topical vasodilator, possibly niacin, which i perceive i may have read about as a topical beauty treatment; if there is then doubling fluid flow at the capillary epithelia could make a topical peelie comfort medicine absorb twice as rapidly or ultra hydrate the dermis causing more rapid diffusion and greater activity of the topical drug causing more rapid function; I have heard of vasoactive peptides, perhaps they could function;
A zero hue change completely comfortable dermal vasodilator might also double the effectiveness of things like peptide beauty topicals, it makes me think though, they could just double the amount of active ingredient;
Find out if topical or oral phenibut, possibly a halogenated phenibut, or GABA active peptide effects dermal nerves to cause the removal of itching that about 2 grams of oral phenibut causes. A body side of the blood brain barrier possibly halogenated phenibut or other body side of the blood brain barrier GABA active molecule could omit CNS GABA activities, it is beneficial to have the drug be absent effects on things like driving ability, reaction time, or social skills.
Thick throat coating drink with peptides might have sufficient surface area to be absorbed as a kind of oral-like peptide dosing form, although I have heard of peptide doses up to 1 mg my perception is that at things like vasopressin and oxytocin it is much less, the most dose effective peptide I have read about, having not looked up other things is a mu opioid peptide active at nanogram amounts, I perceive I read about a halogenated peptide that was twice as effective; at an oral like mouth and throat coating peptide dosing form it is possible the pH of throat saliva could be modified and a mucolytic thing, perhaps something like a protease that is absent an effect on the peptide could make the peptide actually contact the dermis at the throat and mouth, the thing is though, what about stirring? A mm layer of colorant will just sit at a glass, for I perceive, hours, before diffusing; effervescence could do it, so perhaps a bubbly mini-beverage could make the body surface dermis soothing peptide reach the throat mucosa dermis many times more rapidly and before it was washed to the stomach; beneficially the peptide would only work at the mouth and throat so if many doses were consumed because the bubbly mini-beverage tastes good the dose would not vary that much
The 1/10 of a cent printed paper dose technology with the 1 cm^2 doses and enteric layered ink could be beneficial at the developing world, the thing is, what drug, like antibody linked GABA active peptide or drug, would soothe the dermis; tetracycline and possibly minocycline do build up at the dermis, possibly a GABA active drug linked to one of those molecules that has been screened to be a neutral biotic, possibly also finding a variant with greater dermal localization
An all natural product could also function, I do not know of any anaesthetic macroscopic or other fungi, but if there are any, notably GABA receptor active fungi chemicals, then those could be a rapid product.
Actually I am not aware of any natural product that effects GABA receptors, there are commercial natural products chemical libraries that exist, they could screen those to find out if any of the natural products effect GABA receptors, GABA the chemical does not pass the blood brain barrier but might diffuse through the dermis and is only a few $ per 100g.
Other neurotransmitters at the dermis could be anesthetizing, heightening response of anadamide receptors is unknown, a mu-opiate peptide that disintegrates in saliva, mucous of any orifice, and the stomach could be a topical anesthetic, perhaps a mu opiate peptide with a magnesium or calcium or zirconium or scandium atom in the middle of it could persist long enough at the dermis, or lasting about 90 seconds, but continually diffusing from the topical material would function
Orally a mu opioiod peptide attached to a harmless dermal
Localizer molecule, possibly an antibody or a minocycline variant could function. As a topical drug the peptide could be modified so that many enzymes degrade it so it would be nonseperable from the localization chemical which might also be made of enzymatically degradable nucleotides, peptides or proteins
Things that soothe UV Elie's could ask soothe dermatitis as well as a topic dermatitis
Theoretically about7.6 billion people on earth have experienced sun based peelies, so this could benefit people
I have not read about brain area localization technologies applied to mental illness drugs but it seems possible it happens, area (like neocortex) is a different thing than neurochemistry, like say all the neurons with AMPA receptors, or at antischizophrenia medication 5HT2 receptors at pimavanserin,
They could screen a library of fungal chemicals, noting fungi have numerous unusual chemicals after utilizing a radiolabelled acetylating chemical to acetylate a bulk fungal extract, so the chemicals pass the blood brain barrier they could separate the chemicals (more on that at a different note) and feed them to mice, one new chemical each 24 hours, and then brain scan them, and with 300 mice a month later would have 9000 localization maps; if 1 out of 100 had utility they would have 90 maps, also they get maps of where things localize at the body area as well; then noting what the concentration areas are they attach drugs to that fungal molecule and see if the molecules still go to the mapped area; they could come up with molecular variations on the fungal molecules that were absent any drug effect so the drug molecules the fungal molecules were transporting did all the pharmacological activity, it is possible that enzymatically degradable linker molecules could separate the active drug from the fungal transporter. They might do things like this now I do not know.
Separating chemicals from each other with microfluidics,
Another possible way is ion exchange resin inkjet printed beads, i think i have heard of printed microfluicics and i have heard of 3D printed microfluidics, it might be possible to inkjet print digital gradients of ion exchange resin component chemicals, then aim a warming laser to melt them so they bead up, then high frequency nonwarming pulse interval laser to stir them, making a digital gradient of different ion exchange resins responsive to a different chemical; a microfluidic channel layer is then printed atop this (or previously beneath) and each of the separate ion exchange chemical concentrators has its own plumbing, at 32 micrometers radius of the bead then there are 47,851 chemically different chemical separation locations on a 7 cm times 7 cm chip
and possibly
or if 3D printing are printed on peltier cooled paper; or 72°F stable then they melt, liberating contents when a laser shines on them
Another way to make an IER chip is ion exchange resin inkjet printed beads, i think i have heard of printed microfluidics and i have heard of 3D printed microfluidics. It might be possible to inkjet print digital gradients of ion exchange resin component chemicals, then aim a warming laser to melt them so they bead up, then high frequency nonwarming pulse interval laser to stir them, making a digital gradient of different ion exchange resin beads responsive to a different chemical; a microfluidic channel layer is then printed atop this (or previously beneath) and each of the separate ion exchange chemical concentrators has its own plumbing, at 32 micrometers radius of the bead then there are 47,851 chemically different ion exchange resin chemical separation locations on a 7 cm times 7 cm chip
Another way to make an ion exchange resin chip is
If you liquefy an ion exchange polymer with a laser or ambient warmth then use the actual multichannel microfluidics to transport the ion exchange polymer fluid to a particular well. It is it possible to fill 1 million different wells each with a different chemical component ion exchange resin; blending liquid polymers, using microfluidics, at a variety of ion exchange resin chemical components that are blended together to make an array of 10,000 times 10,000 ingredient gradientized different ion exchange resins, each of which will prefer to glom different chemicals than the other, doing that makes 100 million different ion exchange resins at a chip
It also makes me think this is a possible way to do what is effectively screening a library to find completely new ion exchange resin chemistries, if you then pump in the chemical you want to glom on an industrial scale, and have the microfluidic then sequentially (parallel versions could work) liberate the glommed material you could find the most effective ion exchange resin composition out of 100 million (wells) which is likely much more efficient.
Niftily, ion exchange resins tuned to find chemicals of moderate electric charge and higher lipophilicity tend to concentrate the 100 million chemicals most likely to pass the blood brain barrier and omit macrophage and leucocyte response; that kind of ion exchange resin chip could enrich the number of chemicals concentrated from the homogenate with chemicals that have more favorable drug characteristics which are then higher velocity at being turned into drugs
It could be possible to heighten ion exchange resting chemical concentration 11 times greater than wells with ion exchange resin fluid traversing sponge:
ion exchange resin highly porous sponge, blending saliva with rubber cement automatically makes a sponge so a chemistry of sponge making at microfluidic tube chambers could be straightforward, it is possible that rather than an ion exchange resin bead well you would just make a higher volume tube volume of like a (========) filled with ion exchange resin sponge along the access plumbing microfluidic paths; think of a view like a circuit board multiparallelism with tube balloons periodically, the tube balloons full of ion exchange resin sponge could have surface areas to the 3rd power causing them to glom with 32767 (32^3 micrometers) compared with (32^2 times 3 micrometers) at a well, that is near 11 times more material sorted at a similar surface area but sponge hosting volume
If ion exchange resins can glom 1-10 pct of their volume of product, and 47,851
1/32,000 of a milliliter is the volume ofa 1 cm^2 area 32 micrometers deep, if the ion
1 cm cube that is 2/3 tubes concentrates 1-10 pct of chemical so .067 ml of concentrated material and can be used 11 times, so .67 ml of material
Compared with the 27 item multicuboid concentration and sortation reactor which is utilizes 27 cuboids, each 2/3 ion exchange resin sponge tubes, utilizable 11 to 140 timesreactor
Parallelism is beneficial at chemical sortation and chemistry chips, noting the 1 cm^2 two thirds of it being ion exchange sponge filled tubes product sorter and concentrator, When assembling a cuboid (like 27 packages stacked three on a side) microfluidic chemical reactor or ion exchange resin cuboid form, a Lego (or better) interclick of perhaps 16 tubes per Lego circle thing to make a 27 times capacity reactor or product concentrator/sorter goes with having functional fluidic,and microfluidic connection between the cuboids;
the actually fairly mild 16 times 6 circle tube fittings times 27 cuboids times 6 sides all surface Lego circle connectivity reactor would have 15.5k connections, perhaps better than brickle blocks is tHZ (or, just possibly at some polymers lasers like the 3D shape deepwater laser scanner) weldable cube internals, so the up to 10k connections at a 27 cube Lego assemblable reactor (only about 10k connections out of 15.5k if you ignore the surface) could be Thz welded, puffed to fit, or even capped if leaky, at a yield of just 95% 10,000 connector connectiviyy that produces 95% or higher functional plumbing access piping at the reactor multicuboid. The microfluidics at each cube could have some adaptive routing paths to make all the reactor/concentrator well or tubes accessible. I think making these as spheres is also beneficial
The routing adaptive layer at the microfluidics makes it possible at a 27 cuboid reactor to route the chemical containing fluids clean withe reverse direction flow
Ion exchange polymer reloading as microfluidic pumping of new gradual chemical reaction to make new foam, laser or Thz
it is possible a soft flowing polymer with "brickle blocks with adaptive routing" could avoid the actually fairly mild 64 times 27 times 6 all surface Lego circle connectivity, perhaps better than brickle blocks is tHZ weldable cube internals, so the up to 15.5k connections at a 27 cube Lego assemblable reactor could be welded, puffed to fit, or even capped if leaky, producing 95% or higher functional plumbing access piping at the Lego cube. I think making these as spheres is also beneficial
Integrated circuit technology microstructures; doing electrophoresis at microsized channels that are likely larger than the one million lane microfluidic chip I read about; An electrophoresis gel that is only a gel when it is cooled can be partitioned and pumped around when it gently warms, although there is also the possibility of specific area of the chip warming with lasers; the many lane electrophoresis peltier cooled gel turns liquid at 16° then adjacent microfluidic lanes at 32 ° angles pump the chemical or protein enriched fluid at just that area to a new location on the microfluidic chip; 1000 lanes are loaded at one side of each electrophoretic lane, so each electrophoresis lane at the chip can transport 1000 completely different chemicals like proteins
There many ways to structure the microfluidic channels, some of them remind me of the connected and branching conductive lines on the upper surface of photovoltaic
Looks kind of like (→≠») or ==‡== where fluid flow direction meets a bunch of channels connected at an angle or #€[‡] other branched channel geometry
The liquid sample with liquid electrophoretic gel material that gels at 16°C loads at []‡ or ==‡== then peltier cools the multichannel ‡ to gel, then an integrated circuit, which just possibly is at the base of the electrophoresis chip if it is made with integrated circuit technology as compared with polymer technology or MEMS technology, causes voltage at the long (‡)channels on =‡= causing the gel to sort chemicals, this can all be acvomplished with branches of branches at one layer, or, layer atop ==== has another ==‡== fluid path on it; each concentration at the gel channel can be liquified with lasers; microfluidics utilizes published pumps so above 16° C when the === areas when the concentrated chemical are liquid they are micro fluidically motionized to the perimeter of the chip for further use, alternatively they can just be micro fluidically transported to where the yeast are; at another version the microfluidics transport the electrophoresis products to a bunch of wells on a multimillion well integrated circuit technology like planar area, and then to place the yeast and nutrients, the mechanisms automatically, or if feeling thrifty, a human gently places, or possibly even mists the multimillion well plate that has the plurality of separate concentrated chemicals that the microfluidics have placed at predictable locations and at a database, the actual yeast and nutrient solutio; the wells have the volume capacity to feed yeast for 20 unmedicated yeast lifespans noting that yeast now can be made to live 400% longer (salicylic acid) so that way if the 99.999th percentile of longevizatiom causes a lot of yeast longevity they will have nutrients the entire time.
It is possible putting the entire thing on an ultrasonic transducer will heighten fluid diffusibility
To produce a larger amount of chemicals, utilize some other channel sizes, make the multichannel integrated circuit technology electrophoresis chemical concentrator produce 100 MCG of product per each second or third branch (or layer) of sequentially purer electrophoretic ==‡== channels, 1000 or 10,000 ==‡== functioning in parallel, loaded from the sides of chip with larger distributive microfluidic |[]| perimeter channels, provides higher volume of material being concentrated; there are 2500 preconcentration material loader channels on each perimeter side; 100mcg times 10,000 ==‡== channels processes 1000 mg, 1 gram of sample each full cycle, at 20 minutes per cycle then 72 grams of sample can be separated per day, 14 of these chips stacked in parallel can process and purify 1 Kg per 24 hours
If a yeast weighs a microgram, and it is possible there is a yeast species that massive (1 million yeast per gram) then dosing the yeast at the human equivalent of 2 grams to 1 micrograms human equivalent dose with the chemicals concentrated at a microfluidic electrophoresis chip is possible
Notably having millions of wells at an integrated circuit wafer technology or even MEMS polymer form makes the amount of locations so the yeast can be dosed at numerous different orders of magnitude, about 7 orders of magnitude between 2 grams (phenibut) and 600 nanograms (ethynyl estradiol) human equivalent dose at 8 wells of yeast each to get p value
What if the microfluidic chemical sorter had 100 micrometer channels, and 100 of them on each perimeter side that are moving preconcentrated material at each perimeter side of the chip, well that perimeter is a surface area kind of like one cm^2 of motionized fluid; Depth: at 100 micrometers of 16°C electrophoretic liquifiable depth, and 11 minutes per cycle to traverse up to .5 cm (before branching) while having 10,000 micro fluidically addressable tube segment tapping branches (noting the 1 million microfluidic lane chip I read about) then it is like a volume of 1/100th of a ml each 11 minutes or about 1.3 ml per 24 hours. A 7 cm^2 version would produce 63.7 ml of 10,000 sorted chemicals. If less specific lengths of the liquified electrophoretic lane tapping tubes were utilized then you could get larger amounts of 1000 chemical fractions, at 63.7 ml that is 63.7 mg of each of the 1000 different chemicals, although it is actually different than that from solvent mass, so 6.3 to 32 mg per 24 hours could be from 90-49% liquigel solvent
The thing being that the person is producing mg or more of a longevity drug to characterize and quantify at 6 month 96 well plate fish or mice,
If 1 out of every 1000 or 10,000 (different chemical quantities from different resolutions that make .63 to 6.3 mg of concentrated chemical to dose organisms with)
That makes 10,000 or 1000 microfluidic branched channel electrophoresis concentrates, of different numbers of simultaneous chemicals from few or even one to ten times as many from ultrasonicated endolith homogenate. These 1000 or 10,000 chemicals could then be screened knowing, kind of, what they are. Also the microfluidic chip could have 10,000 wells on it so an eentsy sample could be removed if really precise characterization is the thing to do. The amounts, going with the convenient unrealistic presumption of 1000 chemicals of equal amounts is sufficient to dose a mouse with a multidays of dose produced every 24 hours, or at 10,000 chemicals, c elegans. The c elegans could be dosed throughout its life from one 24 hour output. This is
A way to make 99.99th percentile of longevizing chemicals at 24 hours. If age batched c elegans were used for testing then 6 or 9 days would produce a longevity increase %.
Finding the longevity drugs:Use microfluidics to connect the multimicrochannel electrophoresis chemical separator to 100 million yeast colony wells or 100 million human tissue colony wells then use the: the more GFP it produces the longer it has lived varieties of yeast or human tissue culture cells, these emit more light the longer they live then have camera note the most light emitting cells at wells,
It is possible that finding a most longevizing chemical from half a billion different chemicals longevity drug chemical could cause a person to systematically follow twig to branch on a half billion leaf treeee, possibly doing all 29 Binary experiments to find the identity of the chemical. exposing yeast to half a billion different chemicals, then utilizing flow cytometry to find the one with the greatest light emission tells that if it turns the yeast into anendolith lifespan longevity organism it is beneficial to test it on mammals and give it to humans;
Utilizing liposomes with, approximately, just one chemical at them to quantify and characterize new longevity drugs:
With the possibility that a continuum gradient electric charge or pH gradient generation around liposomes, causing them to ensconce different things (or putting phosphatidyl serine and alcohol at an electrophoresis gel that liquefies above 16°C then beaming ultrasonics on the phosphatidyl containing gel produces liposomes to form right there, at a micrometer or eentsier sized piece of a chemical/protein band, ensconcing just that location's chemicals at that electrophoresis band generates a billion or a trillion liposomes, each with mostly just one particular chemical;
You blend the one-liposome-one-chemical liposomes with a one yeast one liposome dilution at a container of fluid, or possibly decanted to make a monolayer; longevity chemicals make the yeast live longer and the most fluorescent yeast has lived the longest, the longest lived 700 yeast are detected with 20 million yeast per second flow cytometry and a numeric characterization of that entire library like endoliths or the kings holly can be made. finding something that makes yeast live numerous orders of magnitude longer and noting flow cytometry lets the yeast live on, many of the yeast remain alive
Then there is a way to trace the long lived yeast to the liposome it ate, and the chemical at the liposome; it has to do with the sensitivity of isotope spectroscopy at flow cytometry, the liposomes can have a large location specifying dose of stable isotopes at them because the electrophoresis gel either migrates a gradient of isotopes with 2-6 different isotopes migrated from each distal part or face of the gel before electrophoresising the screenized material like kings holly or endoliths; so the
isotope gradient, deuterium from one distal part, nitrogen from the other distal part, phosphorus from a transverse side and oxygen from another transverse side; each liposome also then gathers a region associated multiisotope ratio at amounts that can be seen with spectrophotometry of the yeast at the flow cytometer if that narrows the content of the liposome to an eentsy area of the electrophoretic gradient distance (microfluidic is micrometers) then the name of the source and its library of congress number is known and then the process is repeated to find the page paragraph the particular chemical molecule is on.
Microfluidic version, transport numerous nearly identical electrophoretic liposomes sequentially to the yeast upping isotope dosage two or three orders of magnitude, and heightening actual chemical dose.
Liposomes are make able at different volumes, it is possible that liposomes with 300 times more dosing chemical are valued or possibly really eentsy liposomes with higher chemical/spatial resolution are valued.
possible then when a trillion liposomes form there could be a billion liposomes amongst those that had mostly just one kind of chemical or molecule, the one near them on an electrophoretic band that could be ensconced into a liposome at just that minute variation in isoelectric point, pH, p(some other chemical like NH3) (pNH2), so with a trillion gradient formed liposomes you get a billion mostly one chemical liposomes, (even though only a billion of them are highly focused)
Then After dipping, rinsing, liposome surface reacting, the liposomes with something like ribose or something yeast like to eat, put them at a dilution fluid so the ratio of liposomes to yeast is one liposome to one yeast; the yeast eats the liposomes then You can tell if the liposomes chemical longevizes because things like known longevity drug liposomes make their individual yeast live longer, and the liposomes volume and appetizing coating can be adjusted to get the highest ingestion and longevization response
Does this work with daphnia; could you laser zap an isotope gradient preloaded then longevity drug electrophoresisized gel to make eentsy 11 micrometer sized daphnia food cuboids, then feed them to daphnia to characterize and quantify the longevity effects, doing flow cytometry with spectrophotometry to find the isotopes that describe the location on the electrophoresis gel which tells which chemical book I'd or neighborhood it is from; daphnia are possibly a better longevity quantification organism than yeast.
Could isotope labelled electrophoretic liposomes screen billions of potential antibiotics rapidly, the bacteria that eat the liposomes with the most powerfully antibiotic fluotesce the least when all the nonliving bacteria are orocessed at the flow cytometer. new antibiotics save lives
Grow a sprig of the king's holly in isotopically labelled water, or perhaps do gene therapy on it with isotope labelled DNA, or provide it with isotopically labelled amino acids, or do all three with different stable isotopes; then do electrophoresis like microfluidic electrophoresis or bulk liposomal electrophoresis then when the flow cytometer spectrophotometric thing detects isotopes it is detecting them on actual longevity chemicals
It is possible that some drugs or other chemicals have very high area localization at the brain or body as they are, but that nobody knows of any illness linked to that highly reachable mapped area. Based on how it would likely function to attach another molecule, a drug, to the chemical that reaches that map area they could research the highly reachable areas to find out if adjusting their function would benefit humans, anything from actual medical treatment to causing the highly reachable areas to be what I have read is called better than well
Localization mental illness drugs, keep anti psychotics out of sleepiness areas if they still function
People create ways to keep protein from gunking up tubes, it is possible that unlike proteins, peptides, which can also be drugs, have chemical things which make them much easier to keep ungunkifying, from being able to clean all the peptides off of them off with an enzyme, possibly a deaminase, to drastically fewer gooey nooks at the molecule from having masses and structures up to hundreds of thousands of times less complex, it is possible that peptides screened (or produced) at microfluidics are easy to keep from gunking up areas, surfaces, connectors and geometries that accumulate material, microfluidics technologies at peptides could be clean, fast, durable, and with longer reliability cycles; screening libraries of peptides as longevity drugs with 1/1000th the gunkification at chips could heighten reusability which makes, concentrating, sorting natural peptides better, also absent gunkification the thousands more uses per chip makes it hundreds of times more affordable. From the perspective of making drugs and molecules that benefit people the 2019AD also noting the combinatorial space of peptides is kind of like many factorial and new completely artificial amino acids for peptides have been created, so it is a nonfinite factorial there could be a multihundred times better ungunkiness, tidiness, rinsability at peptide sorting and concentrating chips.
Some peptide libraries that could be mass screened for new longevity drugs: if you divide any protein into pieces about half a hundred amino acids long or eentsier it becomes a peptide so any longevity causing proteins could be made into pieces and screened at yeast in the billions (flow cytometry characterizes 10 billion yeast a second) so if the yeast are engineered to make and accumulate more green fluorescent protein the longer they live, it is possible to find out which yeast have the greatest longevity increase. Longevity proteins could be things like naked mole rat organ homogenate, any electrophoretic band that is at 35 year beavers compared with mice, any electrophoretic band from voluntarily provided, or not-alive person protein differences between humans and other primates, protein bands from termite queens (50- I read, 100 year longevity) not at other termites, the protein band differences between the 17 year part of the cicada's phenotype and its one month long mating form, queen bees and regular bees, the longest lived non s cerevisia yeast and s cerevisia and the briefest yeast, electrophoretic protein bands at the kings holly, 40,000 year lifespan thus far, with the protein not at a few other plants, protein bands at endoliths of numerous species (fungi, algae, cyanobacteria, bacteria) electrophoretic that are not at similar organisms, also noting whale longevity the electrophoretic protein bands at 214 year old whale tissue from non alive whales, or 214 year whale tissue from parturition related tissue in the water, that are absent from other whales; note that there are numerous others and that just these 22 could be macroscopically electrophoresized to get 10-1000 micrograms to dose the yeast with.
Also it would be beneficial when generating the peptides, rather than using enzymes, or even a many enzymes at one flask approach, to divide the proteins into peptides at nonpredictable locations because if you always use an enzyme that divides with lysine then the peptides will all have a distal lysine on them, one possibility is UV radiation, other radiation, or bubbling O3 through the flask
Spectroscopy of isotopically labelled peptides, would a spectroscopy beam at a flow cytometer looking at a yeast be able to see femtograms or picograms of radio labelling from a peptide at the yeast, perhaps, perhaps not, what about a one per 100,000 likeliness of seeing the isotopic labelling and the 20 million yeast per second flow cytometer I read they thought they could make, then that is 200 yeast saying which peptide they have been dosed with per second then that is 630.7 million peptides screened annually, with parallel machines, like 11 of them, that is 69 billion peptides screened for longevity effects. There are 2 1/2 longevity peptides out of that I have heard of, so at an extreme, 1 million published peptides so they might find some from a million isotopically labelled peptides that the first 14 days of spectroscopic flow cytometry of yeast finds, and the flow cytometry of fluorescent proteins notes have highest longevity increase. They could then utilize about 11 96 well plates of c elegans or 6 month fish to quantify the effects on vertebrates of the most longevizing 132 of the peptides.
Use peptide sequencers, and if there are microfluidic peptide sequencers, noting the million channel microfluidic chip i read about, creating combinatorial peptides based on software, like AI, like deep learning AI that predicts effective longevity increase and then makes those longevity peptides which are screenable at yeast.
Precluding protein gunk up at microfluidics, at something like fungal or algal endolith homogenate longevity chemical screening or clam homogenate longevity screening with numerous proteins at the ==‡== microfluidic microelectrophoretic sorter could direct each concentrated, separately tapped band of material at the gel to a microfluidic lane that has an interior polymer (or other material) surface charge that minimizes protein accumulation on the channels sides, at that particular protein's actual characteristics, kind of since you know the charge it is at and responds to you can have it traverse channels where that channel's interior charge is neutral or slightly surface-diffident whichever causes less gunking up
Longevity technology: AEDG (Epithalon) is a peptide published as causing 24% greater longevity at mice, and when administered with thymosin, it makes people 4 times more likely to be alive after 6 years; there are now synthetic amino acids they make, so molecular variants of the A, E, D, G amino acids that are synthetic could be made, assembled into new versions of epithalon and quantified as to longevizing effects; with two new atom swapouts or new atoms per each new synthetic amino acid, that is just 16 binary variants to screen at mice, yeast or human tissue culture, notably this provides a kind of nifty rapid research utilizing human cognition originated drug creation. Noting using a D-amino acid is part of how vasopressin was modified to be orally active a person could enjoy, like, and value making an orally available D amino acid or synthetic amino acid version of Epithalon. Like if I were making a variation, thinking as a human, I would find out if acetylated synthetic amino acid variations on any of the amino acids in AEDG were previously existing, then distal to the part of other things Epithalon they might think Epithalon attaches to or activates things with, I would put the acetylated synthetic amino acid because I think it might cause the acetylated amino acid version of Epithalon to pass the blood brain barrier more effectively, predictably, or pre looking things up online I would find out if achiral (nonchiral) synthetic amino acids have been produced (imaginably a dimer, even like the G at AEDG being doubled, a new achiral glycine)
If this were at a public biotechnology maker space like they have in San Francisco and New York City then it would be nifty to have each of 7 or 14 people each think of their own version of AEDG with the makerspace maker shared enthusiasm and actual craft of making, although possibly just ordering (another pineal gland peptide distally attached to AEDG might have synergistic longevity effects, causing greater longevity increase at mice than the published 24%) things. Also if people at the makerspace knew about AI, or even just the deep learning packages they have, then one of the makerspace people could make a computer program that uses deep learning to create AEDG variation molecules, as well as other longevizing molecules and enjoy doing that, as well as of course wondering how well it would do compared with the human originated versions. If AEDG has a longevity effect on c elegans or more beneficially 96 well plate 6 month fish, then 3 of these plates would give results on the 7-14 people's AEDG versions times 2 or more variants each, utilizing 8 organisms to get a p value, that is 224 wells of fish as well as c elegans to quantify all 14-28 variations.
There is also screening a library to find a more longevizing version of epithalon, from a synthetic amino acid perpective, Modifying the four amino acids to have four atom swapouts per amino acid then that is 2^16 screenable variants, near 65,536 versions; going with the idea they could modify the Epithalon on purpose they could make eight atom swaps or additions each at the two amino acids on the side of epitalon that actually activates things (if there is a receptorside, make the two groups of four atom swaps at the receptorside) then these 65,536 could be screened at yeast as well as human tissue culture to find 99.9th percentile of greater longevity increase from the molecules screened. I do not know if Epithalon makes c elegans as well as daphnia live longer or not, if it does then these could be utilized to compare different AEDG, Epithalon variants.
I perceive Epithalon might be tolerated at a multi-order of magnitude dose range, if it is then that suggests something Epithalon activates gets fully activated, kind of saturated; finding out what that saturated thing is, then making more of the saturated thing, or possibly supplementing, as a longevity drug, the amount of the saturated thing could be a new longevity drug; also i do not know if the saturated thing is a cell type, a receptor at the brain (CNS) and at many places at the body, or a chemical. If it is a cell type or receptor then the genetics of the saturated thing like SNPs, alleles, or copy number variations could be part of the genetics of greater longevity; if it is a cell type or receptor then the epigenetics that effect the amount of DNA transcription that effect how frequently or how many of that receptor gets made could be longevity heightening epigenetics, some epigenetics effects function at multiple generations of humans so it is actually possible taking a tuned HDAC inhibitor could turn making lots more of the saturated thing on, or make lots more of it, and that the heightened longevity effect transfers to your children and grandchildren.
Does making BDNF nerve growth factors or other growth factors at the pineal gland heighten longevity and healthspan.
Other pineal hormones, Epithalon, to my perception was developed from researching pineal peptides, it is possible some of the other pineal peptides are more longevizing but at the time a four amino acid quadropeptide was particularly easy to purify and make, it is possible there are lengthier amino acid sequence pineal peptides that can now simply be ordered to be constructed online and screened at mice to find out if they have greater longevizing effects than Epithalon
Does a 300 year lifespan tortoise have a pineal gland? What about a century bird lifespan bird, could a recently alive, hospice-care like administered multicentury lifespan whale's pineal gland have its peptides sequenced, all of these pineal peptides could be tested at mice to find out if they are heighten longevity above epithalon's published 24%
is it possible to grow stem cells from a multicentury lifespan whale, possibly using traces of GI tract tissue at whale poo as a source, or a plucked hair, and then differentiate the multicentury longevity whale's stem cells with tissue culture to make a source of whale tissue to develop longevity drugs from.
Do 300 year tortoises and 300 year sharks have pineal glands, if they do then their likely varied pineal peptide sequences could be characterized at mice as to longevity increase to find a peptide more longevizing than AEDG, epithalon
Longevity genes and proteins at multicentury whales: at humans, HARs, human accelerated regions are areas of the human genome that have changed and diverged with the most velocity, possibly as compared with other primates, humans living much longer than another primates could be linked to HARs, so at multicentury whales do they have cetacean accelerated regions compared with other whales, if they do then genes causing greater whale longevity could be located among these CARs, humans comparing those CARS, as well as human HARs To each other might find shared homologous genes of longevity (compared to nonhuman primates) with the multi century whale versions of the homologous CAR and HAR genes shared areas being particularly longevizing, the actual gene products, like proteins, of the longevizing versions could be heightened at humans as a longevity technology as well as CAR HAR most longevizing genetics gene therapy, germline gene modification, longevity drugs, it could also be that Whale CARs (comparing nearest genome at other whale species) have a completely non homologous to human genes longevity heightening gene area that could be used to develop new longevity techology as well as longevity genes as well.
CARs and HARs as sources of longevity genes, could be sources of longevity genes that benefit humans even when they arise at other species, imaginably noting epithalon's 24% longevity heightening effect, and that i think brain development areas are among the human accelerated regions, HARS, it is possible if you make pineal effecting HARs genes part of the mouse genome the mice might live longer
Complementary
Thinkable: noting three of them as a proof is it possible, along with longevity with healthspan and wellness and being simultaneously benevolent and beneficial and effective at raising children, that there is anything at humans where a larger amoumt of it is always beneficial? This could actually have a mathematical interpretation where some axioms about iniverse math and topology create different and beneficial math limned options;
Getting around all the math of how varieties of sharing can occur at different math systems, dividing odd numbered things on a curved surface or a planar surface causing equal, unequal, matrix equal but anisotropic kinds of partioning, as well as the mathematics of nonpartitionable systems, also interconnected or stand alone systems where all agents always have perfect information arising from the math definitions of the system they are at, consider a person with 360 spherical vision living comfortably in a pleasant easily climbable bowl, who has used science to verify that like 20th century humans communicating the, to my perspective, MWI modified idea, that there is no thing space expands into; the person with the 360° spherical vision actually, at that math space, sees it all, and has the mathematical topological space of having perfect information; the "outer surface" of the bowl is absent detectability with physics, and to have the math function with everything that has ever been measured supports there being no exterior of the bowl (gideon's trumpet, nonfinite length, enumerable surface area possibly is reminiscent of a bowl with a math space where there is a region of presence and non presence at a thing); finding new math spaces that optimize human well being is beneficial, because they make worlds where polythings align with goodness
With math as a beautiful prompt, are there things that if there were heigtened amounts would always be beneficial; well i think it is possible to create a math space where kind of like a topology of all beings having perfect information (360° spherical vision unisided dish), any recombination always produces a more beneficial change in form than omitting any kind of recombination or sorting, while the previous to change universe, at that mathematical topology, is to any sentience fully optimal; any change could heighten an aleph number that a mathematician describes the universe' topology with, one possibility is
So thinking about where i have presence of being, is there a heightened amount is always beneficial
If i can just make atoms, is that a more is better thing, anyone can use them, and noting that the universe is good it just causes a greater amount of universe, using math the new atoms could have equational creatability at various equational areas of the universe, sort of like the way mathematicians are able to definitionally limn an area where "you can add 2 to anything and it will retain its odd or evenness" there is a math system like a topology where it is possible to put more atoms, at a kind of
This is different than the kind of langiage effect "can i find an exception" this is making new math environments where if you say torus then another person saying, thete are two or more circumferences is the way it goes( there is an exception though, if you put a gravitational singularity at the middle of a torus then that middle circumference ballons towards it and at 1 dimensional numbers a balooning occassion causes the middle circumferance to be identical to the outer circumference;
A computer scientist might say, oh, what you mean is algorithms with proofs that limn their behavior, and, among other mathematical forms, i think you would like thinking of mathematically limned "proofed" algorithms that, noting the universe is good, make the universe gooder, so you are utilizing a moment to think of thimgs where at any mathematical or definitional space a greater amount of any anything is gooder;
Whether it has an aleph number or not heighten the universe' aleph number
Just make more atoms, is there a way to figure out if just makimg bosons or just makimg fermions is gooder, have you asked aroumd about a greater quantity of spontaneously resolving quantum objects or also a greater quantity of quantum objects that are unresolvable
Is there a gooder quantum object like a linear photon that gradually builds its brightness so that any organism that liked it could experience it, or if they felt sleepy could just shut their eyelids and go to sleep, , or a true analog thing that is. Planck unit nondependent
If you have a network of n objects such that when superimposed the additive wave is always positive and high thing to the³ compared with thing² and the top half of ac is at an etalon and the container size and when I say container it could just be a parabola of frequencies with the upper part of the parabola a wave frequency larger than the span of the universe and the optics such that only optimal images would retroreflect
A parabolic mirror at a math space where everything was reflected twice at a frequency doubling crystal such that if it were reflected once it would traverse to outside the network and diffuse to the same frequency as the nearest most light emitting object, then shape the topological space so that always happened, all the images viewed would be right side up and the right handedness would be at each image the reflections would be a clearer image each time because they are vector graphics, a casimir flashlight could provide the light that gets
Casimir flashlight automatically motionizes vector graphics
Casimir flashlight attached to an oscillator always gives the oscillator a nudge with some surplus and the surplus makes the parabola higher and raises the curve at the base or at a math space does the up widening traverse thing as it is topologically gyreless, the parabola lifts at the same velocity the math space expands so the proportionate location does not change while the vector graphics reflect twice all the time with the raising and expansion causing a larger number of vector graphic reflections of higher resolution while (at a size changing topological universe)
This could also be accomplished with a gradient refractive image lens at a plasmid shaped topological universe, any occurrence at the sides of the lens would be at total refractive index, and the network nodes at the interior of the tir would experience connectivity without reaching the perimeter; an optical computer in the middle of a curved optic with 3d hat wave, egg cup, such that the tir caused retro reflection that was also a vector graphic; so what the network experiences is heightening vector image quality as the parabola lifts and heightens while the nonperceptible tir at the sides of the plasmid expanded, the duration of the reflected vector graphics is such that any node of the network was equidistant from a light patterns gradual and normal pace versions, the cofocalization of the sides of the parabola would cause the connectivity of the network as well as the nodes to accumulate presence of effect in phase with the network nodes that were around, with math I think you can have a simultaneous group of equations that does that, casimir flashlights work in water and the light would accumulate in place if there were no nodes, noting million year endoliths the nodes would usually be there and they could process the vector graphics from the sides of the parabola or each other the casimir flashlight could actually be a coating,
Thinking about math, although i perceive observing a new gooder thing and heightening the quantity is a gooderness maker
Is it possible; what is a way to observe a new gooder thing?
Well, you could find people that observed new gooder things, then with technology simulate them nonsentiently then actuate a trillion of the nonsentient simulations, then broadcast the new gooder things they observe at a math space of
Simultaneous linear equations of the amount of streamlining, also words that happen at my mind that are 40% or less of what i actually thought, although these 40% words may have a participateable theme of their own, intimations of pattern meaning from form being different
A drug that decreases streamlining some number of units, while being actually recognized as heightening absence of streamlining whete teduced externsl patjwayization is like 900 units of less automatic so another person bringing up an opportunity for a voluntary action would have 90 0units of greater possible voluntaryness this simultaneous equation space where automated respone forms habe less prompting while a new beneficial thing is questing agter psrticipation contributes to a mathematics supporting the possibility of voluntary action (like math supports physics) notably there could be many such drugs which happen to cause gooderness at most of the cumulative occurences, also there are some drugs that cause, at me, a high, while also decreasing streamlining and possibly 40% thoughts, a drug that might do that is phenibut, a nonintoxicatimg drug that removes the abridgement of actual feeling and thouhht of intent 900 units while a different benevolent thing is alignig 900 units of voluntariness as utilization capacity with the change like a beneficial thing, they favor
Genes of openness to experoence; genes of the words in your head being some percentage of what you mean, like actually 100% people, 90% people, 40% people being genomically compared and then their genes used to predict the statements about"words in my head are(amount)% that I mean", that a sample of people with genomes at a database make; when the computer model of the genes that cause some version of this is 95% predictive then the genes of 100% of the words in your head actually mean are promoted, perhaps even made available as a sample with gene therapy or drugs, then to the amount they can, people can purposefully opt for, along with their previously actually knowing what they mean, what they thought, and perhaps for some what they intend, the actual words in their head, like casual narrative thinking, such that then articulate that
It is my perception that the debrisifying or content mutation or content simplification that occurs when the words in my head are at a 40% thought that the actual capacity or ability to be simultaneously cohered at a voluntary action opportunity, so it is more actually voluntary like numbers derived from simultaneous linear equations solved amounts of the possibility an act is voluntary gets greater the more the words in your head are 100% what you mean;
Somebody reads an advertisement for something that is actually beneficial, if the words in their head are 100% of what they mean, and they actually get the beneficial advertised object, then their capacity, like their available amperes of voluntary, is more voluntary than a words at my head communicate only 20% of what I mean person, so this is genetics and drugs that heighten the capacity of humans to be less encumbering to others sense of wondering if they are being fair, if a 100% person volunteers it may actually be more ethical quantified like amperes (compared with ethical the dictionary definition)
genes of
It is possible a nuclear chain reaction, noting it always decoheres more things than it resolves, continuously might be a simple sytem that is unresolvable, a person could only ever say they saw part of it; also some of them are autocatalytic; what is the eentsiest always quantum unresolvable system that humans also like, white light, being physicsy, is definitionally omitting of sufficient observation to be described as its components, although there could be a math thing, or even a physics thing like we emitted some white light so we know how many watts occured,
Stomach lining 72 hour regrow, a tissue culture to test longevity drugs on
Do placentas contain longevizing chemicals and genes, or perhaps also deleterious chemicals to immunize against or epigenetically decrease; placentas, seem like they are super well throughout pregnancy then, i perceive i read, disintegrate at high velocity, i am imagining less than an hour after birth, It could just be autodigestion with enzymes, possibly so things like cows find eating a placenta easier, there is also the possibility that they emit disintegration chemicals even when continuing to be connected to the mothers uterus, do placentas have post birth chemicals which if circulating at a nonpregnant person are deleterious, are genes of placental disintegration activate at nonpregnant people, what do those genes do at a nonpregnant person, would focused epigenetic drugs decrease the amount of what might be deleterious proteins produced from genes st nonpregnant persons; mouse rat tissue transplant is published, the larger abortive rat placentas or duration of research sequentialmultiple mouse abortive placentas prepared from liquid nitrogen frozen placentas could be compared with sequentially gathered live birth placentas so there is a dose every 24 hours; if there is an absence of mouse immunoreactivity to beaver placentas one or two beaver placentas, homogenized, centrifuged, and the supernatant used as a dose, could be administered to age batched mice for many months with the p
High velocity placenta disintegration after a successful birth reminds me of the absence of the octopus sex gland causing eight times greater longevity, also the chemicals at marsupials pregnancies could have different chemicals to screen that have some effects, there are numerous homologous genes at humans and marsupials
Think white
Things humans ever perceive that if there is a greater amount things are gooder
Math spaces like topologies or groups of simultaneous equations that create spaces where all items are fully optimal and liked at any consideration, if change occurs then the change is at a perfect knowledge (math words) which could be nonsentient, that the new changed optimal is more beneficial than the previous optima; if a change occurs without any initiation at a perfect knowledge environment, math, possibly network effects, cause the change to be more beneficial than the previous optima;
There's an image of a travel path that is ±hill both circular directions, it looks like it works because, to my perception the math space of 2 dimensions has different things about it than the math space of 3 dimensions; if I knew a mathematician I would have them advise me on how to make a topology, geometry, data structure, group of simultaneous equations, optimally with continuous curved mathematics that caused anything at that space to be optimal, if purpose occurred new optimal that a perfect knowledge omniscient (this can be nonsentient), observer recognizes as more optimal that the completely optimal thing that preceded it; if a nonsentient origin of change occurred then
Pleasantly giving greater and greater amounts of white light casimir light globe in a museum where every piece of art you see is even more optimal than the previous
Sequential networks at a benefit producing energy environment;
Could be accomplished with chronology, notably global art gallery could have perimeter of time expansion so as the casimir light gets light emittinger more artworks from further get illuminated while the previously near field time perimeter artworks are part of a mathematical topology gooder mathness of network effects that go optimal;optimaler;non sentience sourced optimaler that the math that networks is limned with
Just like a seed and guidelines, or a loop and a disk drive head can make a bunch of math, it is possible there is a parsimonious description of an optimal;sentiencified optimaller; non sentieceified optimaller possibly like a topology mathenatical system that is say all distal sides up or distal sides alternate, center is minimal perturbation (minimax curve), or at electrons on a van degraff sphere the field equation days spread out to equidistant points; so I think there are some parsimonious math descriptions of a trioptimal consistent math thing
So I heard about networks but I don't know anything, I think math networks that share state in realtime like a dish of water of a particular length that has a soliton in it would cause chronodurable geometry states if or when the soliton oscillated differently or dissipated, at a mathematics of a multioptimal network then it would be optimal
then a bunch of vases, each full a different amount, when all connected together will normalize the water
Optimized multioptimal basis description of a mathematical class of networks, the extensible capabilities, are produced at an always optimal environment which could cause anything the network does that the network has any referent to is also optimal; these are math networks with all that math stuff about amount of connections to neighbors, propagation, values (is it like floats, passable object classes(mp4), neural network node contents, aleph numbers)
As well as has virtuous cycle attributes
Multioptimal math with a network that does change causes optimalness where aleph numbers are items at the network and previously described is how changing the aleph number of MWI universes causes a different nomfinnitude of them to be authentically white benevolentultioptimal math space is a preferred configuration because the things that can occur at an optimal network are continuously optimal
Use green shift to make water lifts up valve, changes valve setting, changes the way water lifts up valve cycle like a math thing, doing this a bunch makes a time pump, a quantity of say atoms that have been made to have been energy and matter adjusted from green shift
Could do simple math functions like if there is a vector, or more than one thing, do matrix math on it to
traverse time that they gather together if they fall apart, or have energy distributions minimax point, opposite of minimax curve, or as a if there are two things at once, like calculating a new vector from making an arrow out of two other arrows, the length of the resultant arrow vector reminded of an electret) where if they
Library magazine put gather display; some things are only likely to spontaneously arise where they will succeed, preassured,; what if magazine display was 5000 times more likely to occur in a city of over 3 million, causing 99% likeliness of being imitated brings up the possibility of virtuous cycles that spontaneously arise where, pleasant that they are virtuous, they have a likeliness approaching 100 that they will continue and a near 100 likeliness that if humans are area agentic beings, human participation is voluntary and humans like the virtuous cycle so much it is near 100 pro0agation
Plurality of math forms that are mulioptimal; once an math form like an equation is found at some math there are vistas of generatable equations, it is possible that some of these equations will be math universes where preassured generativeness
Causes them to come into being where they will be authentically multioptimal
The generation of a multioptimal mathematical embodiment on earth, where I did not take a shower; it is possible that a vista of multioptimal equations will have a plurality of instantiations where if some or all of the network components are removed the system will continue optimality, so noting earth, where I did not take a shower if some of my dandruff alights on a circuit board, modifying the network with outside of network content the particular equation at the vista of multioptimal equations that is tested as having the greatest maintenance of multioptimality is the equation the network is built with
Planck length time crystal membrane from being Planck lengthy always has topological membrane shape that causes network to be locationally mathematically congruent with the equations of multioptimality
Eentsy branches to Planck length make time crystals and actualize multioptimal network geometric match space
Math of internet packet topologies
There are many networks at 2019 distribution networks, electrical networks, many-few-node networks like alibaba.com, people 5 year olds sit next to and talk to in kindergarten, phone tower backbone to WiFi sharing phone networks, it is possible that the 10,000 networks people are most cognizant of could be classified and schematized with software then find out if any of them are mathematically translation space translatable to multioptimal networks, of the first 900 that are those that would cost less after going multioptimal would be restructured, possibly just changing a few nodes and structuring data differently would vause multioptimal mathematical form, as the optimality wss perveived at humans as having value then the other networks, as math state spaces are made multioptimal
If they hosted computing molecules instantiating multioptimal networks then endolithic organisms (algae, fungi, cyanobacteria, bacteria) that have lived a million years could be instantiating multioptimal networks, that suggests that it is possible for a network, like all the linked physiochemistry of an algae, to have multioptimal function, as a human finding the math of and building of multioptimal networks that replace other networks that humans like less has value
At MWI universe technology it could be possible to modify the topology of MWI universes to favor the spontaneous generation of only multioptimal networks, and at such universes the emergence of preasssured multioptimal networks would occur at concentration of matter and energy
Casimir flashlight as an energy snack AI lives on
th of thimgs
Longevity technology
There are perhaps more than thousands of species of easily cultured yeast and algae, biologically transformed 10HDA(10H2DA) could come in hundreds or thousands of molecular variations, these could be tested at c elegans and mice, and just to be entertaining finding a yeast and creating a product for less than $5000 could be possible at $32/hr at an MIT undergraduate
40 hours
10 hours
Get list of yeast cultures available from internet, perhaps 300, at $20 per culture that is $6000 so instead get the 72 most different from each other species $1440
Culture 40 flasks of yeast $200
Matrix combine 3 yeasts at one culture flask, culture, ultrasonicate, feed to c elegans at 14 c elegans dishes,
$280
Thats $1920
The MIT student is $ 1280
The remaining money could be used to find out if the two or three most longevizing yeasts, with their broth decanted into each other cause a second biotransformation that puts another moiety on the decanoic acid, centrifuge and do solvent extraction, if possible, feeding it to c elegans to find out if it causes greater longevity than either yeast alone. Then, use UV light on the caprylic acid transforming, longevizing yeast to generate mutants, culture at 7 separate UV flasks and then quantify any c elegans longevity gains from the modified yeast
There may still be enough money to expose 7 yeast cultures at different flasks to UV light until 1/100 are alive, regrow and create 100 millions of mutants, it is possible then with 63 c elegans, 9 per culture dish unless probing functions better with 3 per culture dish, probe the c elegans at day 33 on, to find out if the mutants' 1/100 fraction of the bio transformed caprylic acid has the heightened efficacy to cause greater longevity;
At the varied commercial yeast cultures probe c elegans at day 33 (30 days unengineered, doubled longevity from gene therapy at 60 days is published), days 34, 36,37,38 39, 42, 44, then every 24 hours; day 38 is 24% longevity heightening, day 45 is 50% longevity heightening
if the c elegans live more than 24% longer generously write to 100 mouse researchers asking if they would like a complimentary sample $100
Sake yeast, 4 times the hydroxylated ethyl alkane than regular s cerevisia
Not at the $5000 genetically modify a polyorganism broth of yeast derived from dirt sample sent from moist warm climate or like like Florida grass clippings, transform it with green fluorescent protein, perhaps without a protocol, although there may be one online the GFP will gradually accumulate making the most longevizes the most light emitting
GRAS food flavorings like heptyl esters are food flavorings that look almost like 10HDA
Caprylic acid C10, GRAS, could be fed to fluorescent yeast broth, flow cytometry might find a yeast that put a COOH group on it, the longest lived yeast would emit the most light; read up on if UV exposed yeast with mutations are still automatically GRAS, they might be. Noting just a few hundred yeast species and millions or more mutant yeast 20minutes of flow cytometry could find 99th percentile of longevity at millions of yeast or motr
Use a flow cytometer that lets the user divert the yeast to a flask on the side, so the most longevized yeast can be cultured, if it is a 300 yeast commercial variety use the microbiology lookup book i used in college or software to find out which one it is and order a fresh culture, or, better, and I read it is OK, culture the most light emitting yeast with other yeast until non fluorescent variety is produced, culture 11 flasks of those then matrix batch them for about 4 separate sequential hplcs then you have OK yeast that produces a yeast longevizing decanoic acid
Culture the yeast with caprylic acid and do hplc on one sample $370, possibly complimentary at MIT student
A different version of this that is particularly thrifty, Carolina biological supply has bacterial GFP transformation kits for about $60, you could find out what it does to yeast or you could find out what it does to 60 different, widely varying bacterial species, the bacteria might also do bio transformation, culture the most light emitting bacteria out of 100 (dilute bacterial culture to 24 per slide so you can, possibly, isolate the most light emitting ones or do flow cytometry on billions of them, it is not known if flow cytometry with a UV light next to it is affordable but it could be complimentary to an MIT student, culture and concentrate and dose the c elegans
$720 60 cultures, $120 media and flasks, $300 flow cytometry, $200 c elegans and 70 dishes
Suggest life extension use their affiliation with insilico genetics automated c elegans screening to verify efficacy at making c elegans live longer, then get permission to tell others about the results, that way cloned email letter to 100 supplements makers can be generated
The dyson company could make noiseless at the light coanda effect bathroom fans that operate automatically about twice a day even when no one is around
Longevity technology
I perceive I read some kind of emterosorbent made some sort of organism live 43% longer, yogurt is popular and thick, it is possible that a yogurt that is 4 ounces of emulsified enterosorbent at a cup of yogurt could be quantified at age batched marmosets as well as mice; kaopectate and alumina gel antacids (i perceive one of the enterosorbents i read about is an alumina gel) (aluminum has been linked to nonwellness though) taste good so it could be functional; one thing they could do at mice or pigs is find out if three times a week is sufficient to heighten beneficial longevity effects;
Mitochondrial uncoupling sweetener, I read online that NR nicotinamide riboside causes greater wellness, it also makes humans less strong perhaps because it causes mitochondria to change their form to lots more tiny mitochondria; a person online at imminst.org / longecity.org may have said their plan was to make many more mitochondria per cell, then cause them to be much larger with a high fat(?) Diet; they also linked to a reference that said that at the rat NR is digested into separate nicotinate and ribose, so the person tried taking them as separate ingredients and was less strong, as NR would do; it is possible the larger numbers of tinier mitochondria is linked to mitochondrial uncoupling, which at gene therapy c elegans doubles the lifespan; it is possible that ribose alone could have a longevity effect, a version of ribose that looks like sucrose might taste better than ribose; sucrose is dextrose connected with an acetyl group which enzymes at the small intestine membrane deacetylated, it is possible
Ribose acetyl dextrose
Ribose acetyl fructose
Could cause ribose to have a much better flavor, they could test this on age batched mice to find out if there is a longevity effect
Yeast live 400% longer on salicylic acid; screen a library of a million salicylates at yeast to find out if there are any that more than double that; the longevization effect at mice, i perceive was single digit; they could find out if the 99.999th percentile of longevization screened at yeast has an effect at human cells and tissues, notably stem cells, and things like cartilage, particular cytotypes might make a difference
I saw a math equation once where there were some actual equations and then what I think of as an arbitrarily higher focusable arraying of distinguishable objects, the more times you did the leading sequence equations the higher the resolution got like a vector graphic, using that math as as guide to the optical like topology of the casimir flashlight as coating as light accumulated and twice reflectivity occurred the resolution of the vector graphic would heighten
If the Gödel Escher Bach light cube was actually a different shape, and every face was a vector graphic, the two reflections that cause the images to be right side up and right side right would reach the parabola coated with casimir flashlight from the math topology the leading equation part would always have the time traversing the parabola be utilized to magnify the details whether you went near or far or viewed at an angle the vector graphics resolution would always be higher than the cube
Could that also be utilized at each node at the network to make the kinds of variability that could occur have a so travel,
I think I should think about how to make the network of all the things a girls kindergartner does like goes near her friends and talks with them, how she does certain things at certain times because of the teacher and how to optimize thatp
Should the casimir flashlight coating build nodes faster than the nodes can run
A thing about theMWI is that because there are, i read,more branch universes than the source universes and they all make casimir flashlights with some multiple of casimir flashlight output that is used at the multioptimal network does that make communicating MWI universes (like overlapping MWI) does that give the capacity of the casimir flashlight at the source universe the ability to make more light, if so then the casimir flashlight can make more network nodes, arraying them at nonsaturated topology, than the network, at any velocity can saturate, the benefit is that thinking of kindergartners at kindergarten they are so saturated they ignore things. Some of the time rather than seeking the higher and higher vector graphic detail that PLLs their output, PLL bringing the ability to be on specification sufficiently to have a mathematically optimal output (perhaps one nonsentient node is making new vector graphics being informed and valenced from the other nodes) so that kind of originates optimality
To produce optimumness if a sentience does something benevolent or filler-like at the network the nonsentient nodes have numerous mathematical constructions, the sandwich theory of calculus with internode connections that create math noting the multiples of output of the casimir flashlight, and making nodes at a connection topology at higher velocity than they can be saturated if the sentience has any output to the network, mathematically because of the connection topology of the nodes the sentiences behaviors will always be less than saturation as well as greater than nonactivity because of the sandwich theory of calculus
Is it possible for a network to be optimal if the sentience is only partially attentive; the nodes store utilize and transmit data, transform things, replicate and recycle, depending on the sentiece, and the variety of nonattentiveness it is possible to use true neutral voluntary stimulus to cause a behavioral tropism at less than the threshold of awareness of the sentience, if the network notices the sentience has noticed anything then the stimulus thought to be neutral ceases occurring and a different truly neutral nonperveptible stimulus is utilized, the MWI could have accessible either what the sentience is likely to like, noting it can be encouraged as a tropism absent ever reaching the consciousness of the sentience, or, there could actually be a transfinitude of true neutral nonperceptible stimulus as available MWI data, if the sentience remains inattentive then the math of (is, is a different thing, did not think to participate, had not actually heard or thought of participating), the network is nonsentient, so the math concept of not in use or I have not read next years textbook yet have a math space. I will find out if I can do better than that as I am thinking optimum networks go with continuous math functions, thinking about optimal networks of kindergarteners
Another opportunity is making the math space the network is built at and built of is to find the math system that makes iterated function compression take as few or fewer steps to compress as it does to iterate, or at topology or geometry, simply look up a graphic or utilize an equation with a noniterated solution if you like you can record everything on the internet, find a tree with trillions or quadrillions of leaves and pack it into a human rememberable number sequence, that when a function, cellular automata or something is repeatedly applied to it the data string grows and after a number of iterations the original data, the entire internet is produced, what I perceive college professors and Microsoft found out about this is that it takes a bunch of computing cycles to compress the data tree to seed and equation or cellular automata action table. I think that it could be possible for a person to ask a mathematician "i heard there are noncommutative algebras and that factoring in them is less easy, might take more steps, or sometimes comes up with a big plurality of solutions, looking at it the other way is there such a thing as a hypercommutative algebra or topology where factoring is many times easier and uses fewer operations" note the hypercommutative algebra does not need to be supportive of the rest of known math" then the mathematician says well actually at a completely equational treatment of the 4th dimension it is absent possibility for a knot to stay knotted, the extra movement coordinates make it just slide apart, a topology that causes hyper commutation might actually have less than three dimensions because you are changing the number of state spaces available so there are a different fewer number, one thing that might function is a new fractal dimension between 1 and 2 or 2 and 3 like 2.7
The simplest kind of a casimir flashlight is just an array
Fun thing: a protein that makes a bunch of spaced fins so the space between the fins is the right size to generate casimir effect photons, electrons and even atoms, as a dry heap, at half the volume being gaps a kg of the protein would generate I think, a measurable amount of photons and electrons. There are many ways to produce this, visible photons could be produced
A casimir effect frequency doubling crystal with lanes of space at it internally could make photons then double their frequency
A puffy banana shape with a chamber, or line of chambers in the middle would light up the chambers interior to the puffy banana chambers and a sqiggle banana with a TIR surface and a refractive index could cause the photons to travel the gentle curves, even leading multiple curves to a most lit up chamber § ¿? …
A different thing was is the casimir output of a cool stellar mass, or a just less than fusion mass spaced out so it makes the most casimir photons and electrons possible
if 27 blobs on sticks all point towards a center do you get more casimir effect, does a pile of jacks with more tips generate more casimir effect, what about an atomized spray of quantum dots or a spray of dendric polymers with an omsimi Os at the center and 7, 8, or 9 lines coming from it
The parabola with the upper reaches at a wavelength larger than the diameter of the math topology it happens to be at heightens as the topological universe expands
The mathematical shape that would make the superposition of a minimax curve be planar is at the center of translation of each node at the network
even though minimax is like two u shaped things stacked, this might be like a Mini bowl fore each node, there could be a different, or function combined minibowl for each node, like a physical bowl for location
Could an electron minibowl at semiconductor technology, like at a laser diode, cause electron concentration that minimizes stachasticism and makes higher frequencies or less jitter possible, could electron mini bowls function as higher resolution capacitors with narrower specifiable output,
At a physical matter system could the two u shapes stacked or the sides of the
It you think of stacked U shapes, one inverted, as a minimax curve or bowl shape, with the gap between them less than the leakehage size of the atoms as petals then energy specific particles shape of each egg cups would have two different atoms anemeter scoop radial array is better if it is a globe-like 3D array of bowls (or minimax curves) with different atoms piling up, concentric plates of these (like candypanned sequential globe of anemoment coatings could pile different kinds of atoms or at nanotechnology, partially assembled shapes, if the nanotechnology repeatable building units were like T and [] and (), they could each pile up at optimal concentrations near each other
Breathsavers at base of bowl or minimax curve
Minimax curve inside a bowl, minimax curve with
Air popper popcorn maker with the warming motive air coming from the electrode like, breathsavers like, atom motionized and charge maker at the base of the mowl or the middle of the minimax curve
At a mathematical topology using the equations of 4D or 2D completely spatial topology are there more things a bowl curve or a minimax curve can do, or is there a completely new thing where the 4D causes a new spatial direction of favored velocitization or concentration, it seems like 3D would have
Bowl shaped and minax curve expansions at different spatial dimensions
1D,
2D, the available travel directioms vary distance travelled and velocity on the Y axis, and distributes items spatially on the x axis
At 3D, usual bowls an minimax curves with z-axis effect at bowls and minimax curves from y axis increase
At spatial 4D it could be that a completely new spatial dimension, which i might have read is sometimes called kana is produced, that gives the ability to make bowls that concentrate kana while ignoring z (high sides in kana, null length sides vertically (Z), or adjustable z sides in kana with zero x length, is still a bowl, that reminds me of a kind of tall teleporttion scan line (kana y and z bowl sides only) that if you physically moved it would traverse a person and teleport them to the different kana location, at an x,z, kana Bowl, spatially flat panel that if you put an item with enough energy at it gets out of the y and z and kana only bowl then traverses kana, if you made one then high energy items would teleport kana distances at 3D while remaining at original height and depth (the trajecories original travel path, specifying the curve equations at all 4 dimensions would make a bowl (a bowlful of teleport distance), or an acceleration region that moved things away from the center at a 4D minimax curve
1.2,3,4 with spatial D seem, to my perception to have a thing² amount of greater areas of effect like 2d looks like a U or a ^, and
Without gravity what do bowl curves and minimax curves do, well it is math so you just input the energy numbers at the equation as you like, it seems like bowls and minimax at popular culture just want to move to distal locations or gather at the middle of the bowl from unmentioned gravity, where every input to be calculated is actually a minimatrix or 2 element array, at floating point numbers the attraction or repulsion of any force at the 3Dimensions of the curve, like a bowl, cause movement effect, and the kind of static object new location use of the bowl curve equations are accomplished, and then you know the new location of the object, there are other applications as well, the varying acceleration of the object (Calculus) could be as interesting as where it goes, can you minimax a new idea or trend (hyper popularizing or hyper rejecting, noting that the same idea can be stated as its direct form or, sometimes as s rejectable that build something beneficial if the rejectable is beneficial todistance oneself from) and do different actions, media, or even locations have different minimax curves, or at a bowl, maintenance and continuity of a preferred thing are automatically reinforced (tropism to bowl curves initial x z y coordinates) unless the energy is so high, and at an application this can be benevolent beneficial energy, that the item gets out of the bowl, notably bowls actually select for propagating large qualitative, high amplitude changes while minimax curves actually select for least extraneous variables like friction or anisotropy of a field, so minimax separations, accelerations, and higher distance between origin and object is mathematically related, and equation-friendly, to easy changes of any weight
(What if you use a matrix of greater than 2 items at a bowl or minimax curve, perhaps sometes partially considered as a bowl or minimax curve with gravity) [G, weight], like a 2 times two matrix or a three times three matrix, then at another system of equations, or possible a curve made up of something differently curved than a rotated parabolic spline (bowl) or a stacked two units of parabolic splines of different ±ness,
Thinking about the way minimax curves utilize ±ness as part of their curves mathematical topological identity, could there be a three or four directionality of topological space variation greater than ±ness, possibly the (1i)+7 two component number could have a source identiness at curves (although, things being what they are weight or energy at stationaryness at origin is qualitatively different than curve traversal) so like the actual curved D object would look completely different if the curve math were based around the (±i with ±weight) variable form, I am reminded of the soil triangle with curved sides,
I like continuous functions but there is the possibility that presence or absence of functions causes a discontinuous function at A three or four curvature form, discontinuous functions, to my perception automatically instantiate being able to make a boolean logic math space
New to me is that a transistor on/off boolean logic is two state while the three or greater attributes of a new capability and attribute enhanced alternative expansion to bowl curve and minimax math curve has attributes as well as possible benefits, simultaneous general math awesomemess and actual applications, thinking of optimizing a network, the greater ability to heighten coherent-like behavior and be on-specification from less possibly spurious data or out of context operations has a noncoherence and spurious data preclusion that comes from having a replacement for a bit, or an extra bit, at every item, and, at those networks with data (like although kindergartners and their voluntary networks can be measured, kindergartners are different than, and qualitatively different and greater than just data), with the data at data transfering networks, curve topolgies that surpass minimax curves and bowls are three or four state and that ±i as well as ±weight at a number as attributes would have 2^2 (2²) as the base number of bits as its computational unit, and that zero has on one bit, the empty set has zero bits, a number like 2 has 4 bits, and a number like i0+2 has 3 bits and 2i+1 has has 5 bits, notably this is different than the number of bits at an integer at a bowl math curve or minimax math curve
So an application is this, if you have two systems with three state weight variables the ±amount complex number compont (3i), or Even just presence or absence of a complex number component and a ±integer weight as an application you can make a containing, with accelerative spread (minimax curve) or additional new attribute curve that contributes weighted items to the next, possibly triangular curve in the stack (rather than just grab the three attributes make a triangle it is possible a location tropism at a bowl you can accumulate numerous separate items of different weight
Two different math curves (niftier than bowl or minimax curve), bowl, or minimax, psssing traversing numerically weighted objects to each other, at some positional relations but not others (edge to edge dimers or meet in the middle of the bowl (makes everything from a )( to a two sides of a bowl omitting bases make a tube that gets traversed, absent gravity the new gathering area might be the middle of the tube which has the new attribute of being right at the vertical-like center of the two curves, aimimax vurve stacked on another would create a different mathematical space, with height effect on the weight having anitropy with the tall side connecting the upcurves of one with the upcurves of the other, without energy change at the weigh, but at gravity versions. The possibility of being with a rotation variation of linked rampswith the anitone curve inverted does a different thing)( dimers are anitropic, and stacks are height polarized but functional), >
At two stacked curves you make a new kind of binoast, or if you prefer a weight classifier, possibly much more efficient than some other weight sorters
Sutomated generation of things better than Turing machines, noting 0,0,1 automata, tree automata,
Deep learning ai looks at first million or billion generations of all the n-rule automata,like 0,0,1 where their combinatorial generative space can be computed in less than a month, possibly the first trillion distinct rule seys, at 700different, identical between ruleset different initial values, at some automata there are nstates per cell (stay, make neighbor, leave)
There might be 2^4 (2⁴) attributes to a curve traversing weight with a complex number form, that means those curves could have 16 different things that happen with the travelling mass, hop up, hole pass, chirality, beyond 2 state chirality like 3 symmetry or aperiodic tiling,
What are new attributes of bowl or minimax curves with a complex number component
1D seems to generate math, like things have discontinuous ness without putting boolean logical or set theory at the math space, to make a bowl you day, no travel is visible, unless it isgreater than or equals 700, and if it is above a certain amount then it is like origin + 700 instantly, while at minimax curve it is like saying any amount >0 causes any amount from .1 to 700 units of travel automatically, these have a kind of instantiation logic where if there is a thing, it appears on a number line differently, and, or, not each come from different combined 1D curves or equations for 1D with a minimax inside a bowl or a minimax with a dip in the middle of it, making computers and logic new and replacing set theory seems nice and has utiltity
A modification to 3D bowls and minimax curves is with with modification (upcurved ski jump, or pour spout) the z direction can be modified from monoeffect z± changes or things move up sides of bowls you get ski jump or pour spout as well, it is possible a perimeter lip (ski jumps or pour spouts) could always make output that considered as a group have soliton shapely
Noting 3D bowl or minimax distal tips adjusting z velocity, adding y and x component perhsps a soliton shaped bowl of minimax curve can be produced. Rather than just a U curve, among them one ~~~ frequency valley and two peaks, you could have the two peaks and a velley a U is made from have a soliton ~~~ shape
or a U stacked, the U shape would be direction
Noting soliton shaped emissions from modified lip bowls and minimax curves, when considered as a group are output as a soliton, could an atom beam, directed at a double slit do a new thing with the lines of interference produced, perhaps it would just make tighter narrow lines but I do not know. Soliton shaped beams could have an effect on the traversal distance or highness of resolution at the delayed quantum choice eraser lengthening the duration of the amount of retrocausal time that can be produced or also making effects more precise
At 4D time you get motion concentration or spread out from bowls or minimax curves that causes time pooling (the 4th dimension) or timelines that velocitize away from each other, a possible green shift MWI technology that bowls concentrating cosimilars at the different universes or separates them as much as possible
Schoedingers equation version of MWI is duotree branches, other new versions of or replacements of scroedingers equations might have more simultaneous near universeses, making multiramps at the 4D bowl or minimax curve do parallel sorting, or even realationing
Thinking network optimization casimir flashlight that traverses energy or even data between MWI (from nested overlap MWI connecting casimir flashlights) could use 4D bowl curve technology to drawn content from most similar MWI universe causing less data variability and greater network predictability, supporting optimal network continuity of function
Can minimax and bowl shaped atom-composed sorting curves at nanotechnology function well enough at Santa Barbara california USA June 1st daytime temperatures to make concentrations of nanotechnology repeat units to make nanotechnology objects even though it is warmer than liquid nitrogen on earth's surface , then that would be a Santa barbara temperature nanotechnology that can build things
Similarly could a physical minimax curve or bowl, likely with energy ramps be a catalyst, the bowl or minimax curve could have an osmium, cobalt, or rhenium atom at one angle of the bowl's energy tuned ramo to do catalysis of molecules right at that spot where there was a concentration of ramped atoms
Nanotechnology atom sorter, only atoms of a certain size can take a particular minimax shaped petal energetic acceleration (minimax effect) actual physical shape pathways, also could a stack of mimimax curves, possibly with spaces between them, effectively filter atoms to each of a different angle at 360° as the atoms had the spontsneous energy (like charge), input energy, like voltage, or even stochastic autowiggle to travel the minimax curve or take the right pitch of ramp to get out of the bowl
The tir plasmid is
Is it possible to use a vector graphic of a lookup table, such that if a light wave is in phase it is modally processed but at phase deviation it gets trimmed a Planck length per cycle from a nondynamic material
Longevity technology
They can make many organisms live Longer like double lifespan c elegans, 400% greater lifespan yeast as well as some published
100% and 60% mice; I think they should feed the 400% yeast to c elegans to find out what happens, they could also feed the blenderized c elegans to the yeast
Rather than